Podcasts about Samsung

The girls are very demure this week as they're joined by Bimpe of On The Rocks With B! Bimpe talks about being an entrepreneur who runs no1, not 2 but 3 (almost 4) businesses. She also talks about building a business in a male-dominated field, how she became an entrepreneur at 20 & why she hasn't stopped since university. Then they get into their thoughts on facial dysmorphia, being boxed as an extremely ambitious woman and working towards your dreams rather than just thinking or complaining about them. There's something for everyone in this episode because they also talk about what to do when you're in a rut or are depressed and how to change your life, brick by brick. We hope you enjoy! Join FK & Jola on their Samsung journey and enjoy the brand new range of Samsung Foldables. Shop at https://www.samsung.com/africa_en/storelocator/Choose Bolden products for all your skincare needs like we do! They're available at Medplus Pharmacy locations, Nectar Beauty, Beauty Hut & Teeka4! For US, UK & Canada, shop at www.boldenusa.comDon't forget to use #ISWIS or #ISWISPodcast to share your thoughts while listening to the podcast on X! Rate the show 5 stars on whatever app you listen to and leave a review, share with everyone you know and if you also watch on YouTube, subscribe, like and leave a comment and. be sure to follow us on;Twitter: @ISWISPodcastInstagram: @isaidwhatisaidpodYoutube: @isaidwhatisaidpod Hosted on Acast. See acast.com/privacy for more information.

Good news for data center power consumption and for Samsung's chip-making.Starring Tom Merritt and Robb Dunewood.Show notes can be found here. Hosted on Acast. See acast.com/privacy for more information.

My very old Printer finally failed, Why does the Audacy App ask me to sign in while driving? Google forcing AI on your phone but you can turn it off, Old HP Printer not seeing my new Ink cartridge, Scammers are impersonating local law enforcement, DNS filtering to stay safe!, Audacy App issues on Samsung phone.

Nilay's back! And you can listen to The Vergecast with no ads, if you're a Verge subscriber! Big week, really. Nilay and David start the show by talking about ads, podcasts, platforms, and subscriptions. Then they talk a bunch about Apple's new M5-powered MacBook, iPad, and Vision Pro, and whether a chip bump is worth getting excited about. After that, Nilay reflects on a summer of using AI products, and explains why you can tell the whole story of this generation of AI just by talking about the smart home. Finally, in the lightning round, the hosts talk about AI song covers, Apple TV, TiVo, Roku, Cybertrucks, and the exploding Pixel 10 Pro Fold. Help us improve The Verge: Take our quick survey at theverge.com/survey. Further reading: Ad-free Verge podcasts have arrived Netflix is making a big bet on video podcasts Apple's 2025 iPad Pro comes with an M5 chip inside  Apple just upgraded the Vision Pro with an M5 chip and new strap  Apple's 14-inch MacBook Pro gets an M5 chip bump and faster storage  Logitech made an Apple Pencil-like stylus for the Vision Pro  Apple's rumored smart home display hub might start at $350  Samsung officially teases Moohan headset launch for next week  Apple's future smart glasses could have two separate UIs.  ChatGPT will soon help you shop at Walmart.  How OpenAI plans to make all its money.  Microsoft wants you to talk to your PC and let AI control it   As Microsoft bids farewell to Windows 10, millions of users won't  Spotify says it's working with labels on ‘responsible' AI music tools  DirecTV will soon bring AI ads to your screensaver  OpenAI partners with Broadcom to produce its own AI chips  Sam Altman says ChatGPT will soon sext with verified adults  Apple TV Plus is being rebranded to… Apple TV  Apple exec on Apple TV rebranding: ‘let's just do it' Google's Pixel 10 Pro Fold is the first to ‘go up in smoke during a bend test,' JerryRigEverything says Roku's AI-upgraded voice assistant can answer questions about what you're watching  DirecTV will soon bring AI ads to your screensaver  Soul Against the Machine TiVo has sold its last DVR  Tesla Cybertruck sales are flatlining  Subscribe to The Verge for unlimited access to theverge.com, subscriber-exclusive newsletters, and our ad-free podcast feed.We love hearing from you! Email your questions and thoughts to vergecast@theverge.com or call us at 866-VERGE11. Learn more about your ad choices. Visit podcastchoices.com/adchoices

On this week's show we look at some 1960s and 1970s TV shows that received their series finally in a movie at least ten years after going off the air. We also take a look at five home automation trends for this year and beyond. We also read your emails and take a look at the week's news. News: MTV is Shutting Down Its Last Music Channels, Marking the End of an Era Taylor Swift Eras Tour docuseries, concert film head to Disney+ Apple TV+ Is Getting Rid Of The Plus 47 Years Ago: Rescue from Gilligan's Island Makes TV History On October 14, 1978, television history was made with the premiere of Rescue from Gilligan's Island, the first-ever TV series adapted into a made-for-TV movie. Airing 47 years ago today, this film brought back the beloved cast of the iconic 1960s sitcom Gilligan's Island, reuniting fans with the stranded castaways for a nostalgic adventure. The movie picked up where the series left off, following the bumbling Gilligan and his fellow survivors as they finally escaped their tropical island—only to face new comedic challenges adjusting to modern life. Starring the original cast, including Bob Denver as Gilligan and Alan Hale Jr. as the Skipper, the film captured the charm and humor that made the show a cultural staple. This groundbreaking adaptation paved the way for future TV-to-movie transitions, proving that beloved series could find new life on the small screen. Rescue from Gilligan's Island remains a milestone in TV history, reminding us of the enduring appeal of these lovable castaways. Here are a few other series that got a series finale years after it's TV run ended: Star Trek (ended in 1969) - Star Trek: The Motion Picture (1979) – Relaunched the crew on a new mission, effectively serving as a big-screen continuation and soft finale to the original era's story. Get Smart (ended 1970) -  The Nude Bomb (1980) – Maxwell Smart returns for a solo mission against a mad bomber, providing a comedic capstone to his career. The Munsters (ended 1966) - Munsters' Revenge (1981 TV movie) – The family thwarts a crime ring, reuniting the original cast for a proper send-off. The Adams Family (ended 1966) - Halloween with the New Addams Family (1977 TV movie) – A reunion special where Gomez and Morticia host a haunted party, offering light-hearted closure. Five Smart Home Trends for 2025 and Beyond According to the National Association of Home Builders, two-thirds of consumers desire a connected home. Smart home technology is increasingly impacting property value while homes without such features may soon be worth less. At the annual CEDIA smart home technology expo in Denver, professionals like Kyle Steele, president of Global Wave Integration, and interior designer Toni Sabatino emphasized the importance of staying updated on smart home innovations. They both highlight insights from CEDIA and recent research, offering ideas for your smart home. Today we take a look at the five trends they see for 2025 and beyond. Increasing Seamless IntegrationFor the aesthetics committee, Smart home tech is evolving to blend invisibly into home aesthetics, with slimmer designs, refined finishes, and hidden features in shading, lighting, audio, and furnishings. This shift turns gadgets into design elements, like concealed speakers or artful LED walls, prioritizing user experience over visibility. But underneath it all, seamless integration will enable devices from various brands, such as lights, thermostats, cameras, and voice assistants, to work together as a unified system. This allows unified control via a single app or voice command, intuitive automation based on triggers and a smooth user experience with minimal setup, no delays, and reliable performance. New devices will integrate easily, and a robust network like Wi-Fi 6 supports the ecosystem, enabling complex routines regardless of device brands. Partnering ExpandsCollaborations between tech integrators and designers are growing to make solutions more accessible, especially for non-tech-savvy users like older homeowners. Designers act as bridges, explaining privacy-focused systems, while expos highlight products for storage, entertainment, and monitoring to enhance client value. Wellness TrendingHealth and wellness features are becoming mainstream, including circadian lighting, air/water purification, biophilic elements, and acoustic treatments. These systems promote energy-efficient, livable spaces aligned with natural rhythms, which may be a selling point for those focused on healthier home environments. Products such as smart scales, sleep analyzers, and blood pressure monitors will seamlessly integrate with home automation platforms enabling automations like adjusting room lighting based on sleep patterns detected by sleep sensors or dimming lights if weight trends indicate fatigue. Similarly,  on-demand ECG readings through their mobile app can connect to the automation system to send notifications to family members, doctors and in extreme cases to first responders creating a proactive smart home that responds to vital health data in real time. SecuritySecurity remains a top priority, driving demand for video doorbells, whole-house systems, and cybersecurity measures amid hacking risks. Industry reports project strong growth in global smart home security, urging professionals to educate homeowners on secure setups like strong passwords. Multi-TaskingProducts now multitask across needs like security, comfort, entertainment, and energy savings like smart shading for automated vacation modes or TVs that double as art displays like Samsung's The Frame. Emerging "smart surfaces," such as charging countertops, reflect this versatile, lifestyle-fitting approach.

Episodio 40 de nuestro Unplugged. Esta semana comentamos el nuevo Honor Robot Phone, una idea loca que pretende juntar robótica, móviles e inteligencia artificial. Además, tenemos evento de Samsung a la vista con sus nuevas gafas, hablaremos de los nuevos iPad con M5 y mucho más. ¿Charlamos?

AI is now a standing item at most strategic tables—shapinghow leaders think about markets, talent, and the future of work. But while investment and experimentation are rising fast, most organizations are still in the early chapters of integration. Beneath the strategy, there's a quieter conversation about fear, trust, and what remains uniquely human. In this episode, we sit down with Peter Mulford, Chief AI Officer at BTS, to debate whether AI can ever truly replace emotional intelligence. Together, we explore how we currently think about AI, the edges of what it can do, and what remains uniquely human (for now). Guest Bio: Peter Mulford is the Chief AI Officer and the Global head of the Artificial Intelligence and Innovation Practice (AI&I) for BTS Inc. In this role he helps clients get real impact by working with teams and organizations to transform their business using innovation, future back thinking, Artificial Intelligence, and digital technology. He has over 30 years of experience working with clients around the world in different industries, including Sony Interactive Entertainment, Warner Media, Microsoft, AT&T, Saudi Telecom, Lenovo, Samsung, Telkom South Africa, Merck, Coca-Cola, Toyota, Macys, and others. A sought-out keynote speaker, he has facilitated keynotes at technology and innovation conferences, company offsites, and sales conferences, as well as a private 2-day event with the late Pope Francis and 20 media executives and artists at the Vatican City. Peter joined BTS in 1998 and has worked in its offices in San Francisco, Johannesburg, Tokyo, London and New York. From 2005-2010, he was the Managing Director of BTS's East Coast region, leading the largest global office for BTS through a period of market turbulence and growth during which it more than tripled in size. Prior to BTS he worked for a start-up firm in Tokyo, Japan. He has extensive experience in Retail, Consumer Goods, Electronics and Telecom, among many other industries. Peter holds an MBA in Finance from Columbia Business School, and a Master's in international Affairs with a focus on Asia Pacific Studies from Columbia University. He speaks Japanese.

Most older adults want to age in place, but families and caregivers can't be there 24/7. wisdom.io uses edge computing + radar + computer vision to detect falls and anomalies without wearables—keeping data inside the home and only sending alerts. CEO Cathy Minter shares:• Market reality & unmet needs in home care• Tech stack, privacy, and why edge > cloud for seniors• B2B2C go-to-market (home-care agencies, hospital discharge, 55+ communities)• Pricing, unit economics, and pilot accuracy targets• Samsung partnership: Wisdom on the Go (outside-home safety & gait insights)• Competition (Sensi.AI, SafelyYou) and empathy-led designChapters:00:00 Intro & the aging-in-place gap03:23 Founder story & market stats05:45 Product overview (edge hub, sensors)06:04 Privacy & on-device AI08:33 Hardware/installation Q&A10:08 Sensor fusion & smart-home vision11:25 GTM & channels14:02 Pricing model17:14 Home-care market size18:27 Pilot design & accuracy20:00 Competitors & differentiation23:10 Scale strategy & Samsung26:42 Closing & investor notes

Connect with Josh Furstoss: https://www.linkedin.com/in/josh-furstoss/Follow Josh on X: https://x.com/josh_furstoss

A 99 está apostando alto no retorno do 99Food ao Brasil. Depois de Goiânia e São Paulo, o serviço acaba de chegar ao Rio de Janeiro e promete expandir rapidamente para outras capitais. Em entrevista ao Podcast Canaltech, Bruno Rossini, Diretor Sênior de Comunicação da 99, explica como a 99 pretende redefinir o mercado de delivery com tecnologia própria, preços mais justos e uma proposta diferente da concorrência. A ideia é clara: crescer o mercado, e não apenas disputar espaço. Para isso, a empresa aposta em entregas mais rápidas, taxas menores para restaurantes e melhor remuneração para entregadores. No longo prazo, o objetivo é ainda mais ambicioso: investir em um superapp brasileiro, integrando mobilidade, pagamentos e delivery em uma só experiência digital. Você também vai conferir: Samsung confirma data do lançamento do seu óculos futurista de realidade estendida, brasileiro compra o carro elétrico mais rápido do mundo, que chega a quase 500 km/h, Anatel multa Mercado Livre em R$ 6,27 milhões por venda de eletrônicos ilegais, antenas da Starlink são instaladas em locomotivas no Brasil e Cisco libera seis cursos gratuitos de IA e tecnologia com certificado online. Este podcast foi roteirizado e apresentado por Fernanda Santos e contou com reportagens de Vinicius Moschen, Danielle Cassita, Marcelo Fischer, sob coordenação de Anaísa Catucci. A trilha sonora é de Guilherme Zomer, a edição de Jully Cruz e a arte da capa é de Erick Teixeira.See omnystudio.com/listener for privacy information.

This week's episode is for the girls - fitting, since International Day of The Girl Child just passed by. We are joined by Malala Yousafzai, a Pakistani female education activist, who reminds us the importance of education, community, structure and balance for every girl, everywhere in the world. She gets real about the pressures and life differences in being Malala the activist vs Malala the woman. She also shares some (extremely peaceful) advice on dilemmas about a girl who built her family business from the ground-up, only to be pushed out, and another who believes her siblings hate her. It's thoughtful, peaceful and very for the girls

Listen to a recap of the top stories of the day from 9to5Mac. 9to5Mac Daily is available on iTunes and Apple's Podcasts app, Stitcher, TuneIn, Google Play, or through our dedicated RSS feed for Overcast and other podcast players. Sponsored by 9to5Mac Daily Plus: Get ad-free versions of every episode by visiting 9to5mac.com/join.  New episodes of 9to5Mac Daily are recorded every weekday. Subscribe to our podcast in Apple Podcast or your favorite podcast player to guarantee new episodes are delivered as soon as they're available. Stories discussed in this episode: Apple smart home hub reportedly marks shift in how new products are built as price target emerges iPhone 17 demand sees Apple almost catch Samsung, says IDC Apple announces iPhone Air will go on sale in China later this week Listen & Subscribe: Apple Podcasts Overcast RSS Spotify TuneIn Google Podcasts Subscribe to support Chance directly with 9to5Mac Daily Plus and unlock: Ad-free versions of every episode Bonus content Catch up on 9to5Mac Daily episodes! Don't miss out on our other daily podcasts: Quick Charge 9to5Toys Daily Share your thoughts! Drop us a line at happyhour@9to5mac.com. You can also rate us in Apple Podcasts or recommend us in Overcast to help more people discover the show.

Huyen Tue Dao makes her triumphant return to the show just in time to join Mishaal Rahman and Ron Richards to talk more AI in Android, the latest leaks with Android XR and weigh in on watches!Note: Time codes subject to change depending on dynamic ad insertion by the distributor00:02:00 - NEWSIn the court room, Google thinks they should be allowed to bundle Gemini with their appsWear OS 6 comes to older versions of the Pixel WatchAhead of it's return, Pebble relaunches it's appstore! Patron Pick: Not to be pushed around, LineageOS releases Android 16 despite lack of support from Google00:32:00 - HARDWAREFlorence Ion weighs in with her review of the Pixel Watch 4 and the Pixel Buds 2A Google reveals how they built the hinge on the Pixel 10 Pro Fold without gearsWe get the most comprehensive collection of leaks ahead of Project Moohan's release from Samsung, maybe happening soon?Motorola gets in on the thin phone game with the latest version of their Edge 70 device00:58:45 - APPSWhew! Google Messages will now protect you from NSFW videos containing nudityDetails on the potential Theme Manager coming to Android Nano Banana continues it's meteoric rise within Google as it expands to more apps01:09:42 - FEEDBACKLarry from Kennewick, Washington wants to know if he should get the Pixel 10 Pro?Andrew is considering jumping from the Pixel to Samsung, what should he lookout for?Craig shares his own personal unlimited storage workaround scheme Hosted on Acast. See acast.com/privacy for more information.

October Horror: #14 out of 31: Go in cold and you will have a blast. The biggest surprise of the year! I loved it! Companion (2025) - 4K UHD Blu-Ray Review ROCKFILE Podcast 886 #companionmovie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

I had a chance to chat with my friend Mariusz (Riverside) about his upcoming Lunatic Soul album, The World Under Unsun due October 31, 2025! This is the audio-only podcast, the video will be on my YouTube channel. Mariusz Duda Conversation (2025) - Interview ROCKFILE Podcast 887 #mariuszduda #lunaticsoul #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/subsonic-voodoo/terrify License code: ZAVGTO3RMPOTBVE1  ~  

Ce mercredi 15 octobre, François Sorel a reçu Nicolas Guyon, animateur du podcast "Comptoir IA", Fanny Bouton, responsable du programme startup d'OVHCloud, et Zoé Mohl, investisseur chez Balderton Capital. Ils se sont penchés sur la promesse de davantage d'investissement en Chine par Tim Cook pour miser plus que jamais sur le marché chinois, la relance de la course aux casques immersifs avec le duel annoncé entre le Vison Pro M5 d'Apple et le Galaxy XR de Samsung, ainsi que le refus d'Altice France sur l'offre de rachat de 17 milliards d'euros de SFR par Bouygues, Orange et Free, dans l'émission Tech & Co, la quotidienne, sur BFM Business. Retrouvez l'émission du lundi au jeudi et réécoutez-la en podcast.

A Bia foi fundo em estudos interessantíssimos, incluindo um sobre a relação entre polidez e desempenho de LLMs, e um modelo nanico da Samsung.

In this episode of Medsider Radio, we sat down with Young Juhn, CEO of Wellysis.Wellysis is the Samsung spinout behind S-Patch, a lightweight wearable that enables long-term ECG monitoring without the discomfort of established cardiac monitoring devices.Young has spent more than two decades bridging hospital and home-based care — from his early career at Johnson & Johnson, to more than a decade at Kaiser Permanente, to leading healthcare innovation at Samsung before spinning out Wellysis in 2019.In this interview, Young shares why patient interviews should shape product design, how regulatory clearance is just the starting point for global commercialization, and why building a medical foundation before branching into consumer markets is critical for lasting adoption.Before we dive into the discussion, I wanted to mention a few things:First, if you're into learning from medical device and health technology founders and CEOs, and want to know when new interviews are live, head over to Medsider.com and sign up for our free newsletter.Second, if you want to peek behind the curtain of the world's most successful startups, you should consider a Medsider premium membership. You'll learn the strategies and tactics that founders and CEOs use to build and grow companies like Silk Road Medical, AliveCor, Shockwave Medical, and hundreds more!We recently introduced some fantastic additions exclusively for Medsider premium members, including playbooks, which are curated collections of our top Medsider interviews on key topics like capital fundraising and risk mitigation, and 3 packages that will help you make use of our database of 750+ life science investors more efficiently for your fundraise and help you discover your next medical device or health technology investor!In addition to the entire back catalog of Medsider interviews over the past decade, premium members also get a copy of every volume of Medsider Mentors at no additional cost, including the latest Medsider Mentors Volume VII. If you're interested, go to medsider.com/subscribe to learn more.Lastly, if you'd rather read than listen, here's a link to the full interview with Young Juhn.

¡Bienvenidos, Curiosinautas!

OpenAI debuted the future of ChatGPT with Agents and Apps. How will that impact work?

Amazon digital picture frames have begun showing ads, as have Samsung refrigerators, whether the owners like them or not - which I believe will become more common in the future. https://www.lehtoslaw.com

October Horror: #13 out of 31: This new 4K edition is pretty hard to find...but worth it. Night Of The Living Dead (1990) - 4K UHD Blu-Ray Review ROCKFILE Podcast 885 #nightofthelivingdeadmovie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

October Horror: #12 out of 31: My fourth of four Hellraiser movies from the 4K box set. Hellraiser: Bloodline (1996) - 4K UHD Blu-Ray Review ROCKFILE Podcast 884 #hellraiserbloodline #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

October Horror: #11 out of 31: My third of four Hellraiser movies from the 4K box set. Hellraiser III: Hell On Earth (1992) - 4K UHD Blu-Ray Review ROCKFILE Podcast 883 #hellraiser3movie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.

Dr. Hope Rugo and Dr. Giuseppe Curigliano discuss recent developments in the field of bispecific antibodies for hematologic and solid tumors, including strategies to optimize the design and delivery of the immunotherapy. TRANSCRIPT Dr. Hope Rugo: Hello and welcome to By the Book, a podcast series from ASCO that features engaging conversations between editors and authors of the ASCO Educational Book. I am your host, Dr. Hope Rugo. I am the director of the Women's Cancers Program and division chief of breast medical oncology at the City of Hope Cancer Center. I am also the editor-in-chief of the Educational Book. Bispecific antibodies represent an innovative and advanced therapeutic platform in hematologic and solid tumors. And today, I am delighted to be joined by Dr. Giuseppe Curigliano to discuss the current landscape of bispecific antibodies and their potential to reshape the future of precision oncology. Dr. Curigliano was the last author of an ASCO Educational Book piece for 2025 titled, "Bispecific Antibodies in Hematologic and Solid Tumors: Current Landscape and Therapeutic Advances." Dr. Curigliano is a breast medical oncologist and the director of the Early Drug Development Division and chair of the Experimental Therapeutics Program at the European Institute of Oncology in Milan. He is also a full professor of medical oncology at the University of Milan. You can find our disclosures in the transcript of this episode. Dr. Curigliano, Giuseppe, welcome and thanks for being here. Dr. Giuseppe Curigliano: Thanks a lot for the invitation. Dr. Hope Rugo: Giuseppe, I would like to first ask you to provide some context for our listeners on how these novel therapeutics work. And then perhaps you could tell us about recent developments in the field of bispecific antibodies for oncology. We are at a time when antibody-drug conjugates (ADCs) are all the rage and, trying to improve on the targeting of specific antigens, proteins, receptors in the field of oncology is certainly a hot and emerging topic. Dr. Giuseppe Curigliano: So, thanks a lot. I believe really it was very challenging to try to summarize all the bispecific antibodies that are under development in multiple solid tumors. So, the first thing that I would like to highlight is the context and the mechanism of action of bispecific antibodies. Bispecific antibodies represent a groundbreaking advancement in cancer immunotherapy, because these engineered molecules have the unique ability to target and simultaneously bind to two distinct antigens. That is why we call them bispecific. So typically, one antigen is expressed on the tumor cell and the other one is expressed on the immune effectors, like T-cell or natural killer cells. So this dual targeting mechanism offers several key advantages over conventional monoclonal antibodies because you can target at the same time the tumor antigen, downregulating the pathway of proliferation, and you can activate the immune system. So the primary mechanism through which bispecific antibodies exert their therapeutic effects are: First, T-cell redirecting. I mean, many bispecific antibodies are designed to engage tumor-associated antigens like epidermal growth factor receptor, HER2, on the cancer cell and a costimulatory molecule on the surface of T-cell. A typical target antigen on T-cell is CD3. So what does it mean? That you activate the immune system, immune cells will reach the tumor bed, and you have a dual effect. One is downregulating cell proliferation, the other one is activation of the immune system. This is really important in hematological malignancies, where we have a lot of bispecifics already approved, like acute lymphoblastic leukemia or non-Hodgkin lymphoma.  The second, in fact, is the engagement of the tumor microenvironment. So, if you engage immune effector cells like NK cells or macrophages, usually the bispecific antibodies can exploit the immune system's ability to recognize and kill the immune cells, even if there is a lack of optimal antigen presentation.  And finally, the last mechanism of action, this may have a role in the future, maybe in the early cancer setting, is overcoming immune evasion. So bispecific antibodies can overcome some of the immune evasion mechanisms that we see in cancer. For example, bispecific antibodies can target immune checkpoint receptors, like PD-L1 and CTLA-4. Actually, there is a bispecific under development in breast cancer that has a dual targeting on vascular endothelial growth factor receptor and on PD-L1. So you have a dual effect at the same time. So, what is really important, as a comment, is we need to focus first on the optimal format of the bispecific, the optimal half-life, the stability, because of course even if they are very efficient in inducing a response, they may give also a lot of toxicities. So in clinical trials already, we have several bispecifics approved. In solid tumors, very few, specifically amivantamab for non-small cell lung cancer, but we have a pipeline of almost 40 to 50 bispecifics under development in multiple solid tumors, and some of them are in the context of prospective randomized trials. Dr. Hope Rugo: So this is really a fascinating area and it's really exciting to see the expansion of the different targets for bispecific antibodies. One area that has intrigued me also is that some of the bispecifics actually will target different parts of the same receptor or the same protein, but presumably those will be used as a different strategy. It's interesting because we have seen that, for example, in targeting HER2. Dr. Giuseppe Curigliano: Oh, yes, of course. You may consider some bispecifics like margetuximab, I suppose, in which you can target specifically two different epitopes of the same antigen. This is really an example of how a bispecific can potentially be more active and downregulating, let us say, a pathway, by targeting two different domains of a specific target antigen. This is an important point.  Of course, not all the bispecifics work this way, because some of the target antigen may dimerize, and so you have a family of target antigen; an example is epidermal growth factor receptor, in which you have HER1, HER2, HER3, and HER4. So some of them can inhibit the dimerization between one target antigen and the other one, in order to exert a more antiproliferative effect. But to be honest, the new generation of them are more targeting two different antigens, one on the tumor and one on the microenvironment, because according to the clinical data, this is a more efficient way to reduce proliferation and to activate the immune system. Dr. Hope Rugo: Really interesting, and I think it brings us to the next topic, which is really where bispecific antibodies have already shown success, and that is in hematologic malignancies where we have seen very interesting efficacy and these are being used in the clinic already. But the expansion of bispecific antibodies into solid tumors faces some key challenges. It's interesting because the challenges come in different shapes and forms. Tell us about some of those challenges and strategies to optimize bispecific antibody design, delivery, patient selection, and how we are going to use these agents in the right kind of clinical trials. Dr. Giuseppe Curigliano: This is really an excellent question because despite bispecific antibodies having shown a remarkable efficacy in hematological malignancies, their application in solid tumors may have some challenges. The first one is tumor heterogeneity. In hematological malignancy, you have a clear oncogene addiction. Let us say that 90% of the cells may express the same antigen. In solid tumors, it is not the same. Tumor heterogeneity is a typical characteristic of solid tumors, and you have high heterogeneity at the genetic, molecular, and phenotypic levels. So tumor cells can differ significantly from one another, even if within the same tumor. And this heterogeneity sometimes makes it difficult to identify a single target antigen that is universally expressed in an hematological malignancy. So furthermore, sometimes the antigen expressed on a tumor cell can be also present on the normal tissue. And so you may have a cross-targeting. So let's say, if you have a bispecific against epidermal growth factor receptor, this will target the tumor but will target also the skin with a lot of toxicity. The second challenge is the tumor microenvironment. The solid tumor microenvironment is really complex and often immunosuppressive. It is characterized by the presence of immunosuppressor cells like the T regulators, myeloid derived suppressor cells, and of course the extracellular matrix. All these factors hinder immune cell infiltration and also may reduce dramatically the effectiveness of bispecific antibodies. And as you know, there is also an hypoxic condition in the tumor. The other challenge is related to the poor tumor penetration. As you know also with antibody-drug conjugate, only 1 to 3% of the drug will arrive in the tumor bed. Unlike hematological malignancies where tumor cells are dispersed in the blood and easily accessible, the solid tumors have a lot of barriers, and so it means that tumor penetration can be very low. Finally, the vascularity also of the tumor can be different across solid tumors. That is why some bispecifics have a vascular endothelial growth factor receptor or vascular endothelial growth factor as a target. Of course, what do we have to do to overcome these challenges? First, we have to select the optimal antigen. So knowing very well the biology of cancer and the tumor-associated antigens can really select a subgroup of epitopes that are specifically overexpressed in cancer cells. And so we need to design bispecifics according to the tumor type. Second, optimize the antibody format. So there are numerous bispecific antibody formats. We can consider the dual variable domain immunoglobulin, we specified this in our paper. The single chain variable fragments, so FC variable fragments, and the diabodies that can enhance both binding affinity and stability. And finally, the last point, combination therapies. Because bispecific antibodies targeting immune checkpoint, we have many targeting PD-1 or PD-L1 or CTLA-4, combined eventually with other immune checkpoint inhibitors. And so you may have more immunostimulating effect. Dr. Hope Rugo: This is a fascinating field and it is certainly going to go far in the treatment of solid tumors. You know, I think there is some competition with what we have now for antibody-drug conjugates. Do you see that bispecifics will eventually become bispecific ADCs? Are we going to combine these bispecific antibodies with ADCs, with chemotherapy? What is the best combination strategy do you think looking forward? Dr. Giuseppe Curigliano: So, yes, we have a bispecific ADC. We have actually some bispecifics that are conjugated with a payload of chemotherapy. Some others are conjugated with immunoactivation agents like IL-2. One of the most effective strategies for enhancing bispecific activity is the combination therapy. So which type of combination can we do? First, bispecific antibodies plus checkpoint inhibitors. If you combine a bispecific with an immune checkpoint, like anti-PD-1, anti-PD-L1, or anti-CTLA-4, you have more activity because you have activation of T-cells, reduction of immunosuppressive effect, and of course, the capability of this bispecific to potentiate the activity of the immune checkpoint inhibitor. So, in my opinion, in a non-small cell lung cancer with an expression of PD-L1 more than 50%, if you give pembrolizumab plus a bispecific targeting PD-L1, you can really improve both response rate and median progression-free survival.  Another combination is chemotherapy plus bispecific antibodies. Combining chemotherapy with bispecific can enhance the cytotoxic effect because chemotherapy induces immunogenic cell death, and then you boost with a bispecific in order to activate the immune system. Bispecific and CAR T-cells, until now, we believe that these are in competition, but this is not correct. Because CAR T-cells are designed to deliver an activation of the immune system with the same lymphocytes engineered of the patients, with a long-term effect. So I really do not believe that bispecifics are in competition with CAR T-cells because when you have a complete remission induced by CAR T-cell, the effect of this complete remission can last for years. The activity of a bispecific is a little bit different. So there are some studies actually combining CAR T-cells with bispecifics. For example, bispecific antibodies can direct CAR T-cells in the tumor microenvironment, improving their specificity and enhancing their therapeutic effect.  And finally, monoclonal antibody plus bispecific is another next generation activity. Because if you use bispecific antibodies in combination with existing monoclonal antibodies like anti-HER2, you can potentially increase the immune response and enhance tumor cell targeting. In hematological malignancies, this has been already demonstrated and this approach has been particularly effective. Dr. Hope Rugo: That's just so fascinating, the whole idea that we have these monoclonal antibodies and now we are going to add them to bispecifics that we could maybe attach on different toxins to try and improve this, or even give them with different approaches. I suppose giving an ADC with a bispecific would sort of be similar to that idea of giving a monoclonal antibody with the bispecific. So it is certainly intriguing. We also will need to understand the toxicity and cost overall and how we are going to use these, the duration of treatment, the assessment of biomarkers. There are just so many different aspects that still need to be explored.  And then with that idea, can you look ahead five or ten years from now, and tell us how you think bispecific antibodies will shape our next generation cancer therapies, how they will be incorporated into precision oncology, and the new combinations and approaches as we move forward that will help us tailor treatment for patients both with solid tumors and hematologic malignancies? Are we going to be giving these in early-stage disease in solid tumors? So far, the studies are primarily focusing on the metastatic setting, but obviously one of the goals when we have successful treatments is to move them into the early stage setting as quickly as possible. Dr. Giuseppe Curigliano: Let us try to look ahead five years rather than ten years, to be more realistic. So, personally I believe some bispecifics can potentially replace current approaches in specifically T-cell selected population. As we gather more data from ongoing clinical trials and we adopt a deeper understanding of the tumor immuno microenvironment, of course we may have potentially new achievement. A few days ago, we heard that bispecifics in triple negative breast cancer targeting VEGF and PD-L1 demonstrated an improvement in median progression-free survival.  So, how to improve and to impact on clinical practice both in the metastatic and in the early breast cancer setting or solid tumor setting? First, personalized antigen selection. So we need to have the ability to tailor bispecific antibody therapy to the unique tumor profile of individual patients. So the more we understand the biology of cancers, the more we will be able to better target. Second, bispecific antibodies should be combined. I can see in the future a potential trial in which you combine a bispecific anti-PD-L1 and VEGF with immune checkpoint inhibitor selected also to the level of expression of PD-L1, because integration of antibody bispecific with a range of immunotherapies, and this cannot be only immune checkpoint inhibitors, but can be CAR T-cells, oncolytic viruses, also targeted therapy, will likely be a dominant theme in the coming years. This combination will be based on the specific molecular and immuno feature of the cancer of the patient.  Then we need an enhanced delivery system. This is really important because you know now we have a next generation antibody. An example are the bicyclic. So you use FC fragment that are very short, with a low molecular weight, and this short fragment can be bispecific, so can target at the same time a target antigen and improving the immune system. And so the development of this novel delivery system, including also nanoparticles or engineered viral vectors, can enhance the penetration in the tumor bed and the bioavailability of bispecific antibodies. Importantly, we need to reduce toxicity. Until now, bispecifics are very toxic. So the more we are efficient in delivering in the tumor bed, the more we will reduce the risk of toxicity. So it will be mandatory to reduce off-target effects and to minimize toxicity.  And finally, the expansion in new indication. So I really believe you raised an excellent point. We need to design studies in the neoadjuvant setting in order to better understand with multiple biopsies which is the effect on the tumor microenvironment and the tumor itself, and to generate hypotheses for potential trials or in the neoadjuvant setting or in those patients with residual disease.  So, in my opinion, as we refine design, optimize patient selection, and explore new combination, in the future we will have more opportunity to integrate bispecifics in the standard of care. Dr. Hope Rugo: I think it is particularly helpful to hear what we are going to be looking for as we move forward to try and improve efficacy and reduce toxicity. And the ability to engineer these new antibodies and to more specifically target the right proteins and immune effectors is going to be critical, of course, moving forward, as well as individualizing therapy based on a specific tumor biology.  Hearing your insights has been great, and it really has opened up a whole area of insight into the field of bispecifics, together with your excellent contribution to the ASCO Educational Book. Thank you so much for sharing your thoughts and background, as well as what we might see in the future on this podcast today. Dr. Giuseppe Curigliano: Thank you very much for the invitation and for this excellent interview. Dr. Hope Rugo: And thanks to our listeners for joining us today. You will find a link to the Ed Book article we discussed today in the transcript of this episode. It is also, of course, on the ASCO website, as well as on PubMed. Please join us again next month on By the Book for more insightful views on the key issues and innovations that are shaping modern oncology. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Follow today's speakers:       Dr. Hope Rugo  @hope.rugo  Dr. Giuseppe Curigliano @curijoey Follow ASCO on social media:       @ASCO on X (formerly Twitter)       ASCO on Bluesky      ASCO on Facebook       ASCO on LinkedIn       Disclosures:      Dr. Hope Rugo:   Honoraria: Mylan/Viatris, Chugai Pharma  Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer  Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx  Dr. Giuseppe Curigliano: Leadership: European Society for Medical Oncology, European Society of Breast Cancer Specialists, ESMO Open, European Society for Medical Oncology Honoraria: Ellipses Pharma Consulting or Advisory Role: Roche/Genentech, Pfizer, Novartis, Lilly, Foundation Medicine, Bristol-Myers Squibb, Samsung, AstraZeneca, Daiichi-Sankyo, Boerigher, GSK, Seattle Genetics, Guardant Health, Veracyte, Celcuity, Hengrui Therapeutics, Menarini, Merck, Exact Sciences, Blueprint Medicines, Gilead Sciences Speakers' Bureau: Roche/Genentech, Novartis, Pfizer, Lilly, Foundation Medicine, Samsung, Daiichi Sankyo, Seagen, Menarini, Gilead Sciences, Exact Sciences Research Funding: Merck Travel, Accommodations, Expenses: Roche/Genentech, Pfizer, Daiichi Sankyo, AstraZeneca      

October Horror: #10 out of 31: My second of four Hellraiser movies from the 4K box set. Hellbound: Hellraiser 2 (1988) - 4K UHD Blu-Ray Review ROCKFILE Podcast 882 #hellraiser2movie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

Max Richter grew up in Stuttgart, Germany, surrounded by cameras—his father was a photographer with a Leica who ran an advertising business. After studying engineering and business, Max found himself restless in corporate life, eventually making his way to Shenzhen, China, where he met a campus legend named JK who had borrowed $2,000 from his father to start a camera company. What happened next was a decade-long journey of near-bankruptcy, pivotal pivots, and ultimately building Insta360 into a company that challenged GoPro and partnered with the very camera brand that filled Max's childhood home. Today, Max serves as a co-founder of Insta360, a company that's redefined how millions of people capture and share their lives. In this episode, you'll discover: The "dark year" of 2017 when Insta360 had over 100 employees, was running out of cash, and Samsung had just entered their market—and the unexpected user behavior that saved the company Why the moment you're closest to giving up is often the exact moment you need to push through, and how this principle turned a struggling startup into a company that makes $30+ million annually The career advice Max wishes he'd known at 25 about the dangers of overthinking and why "just starting" beats perfect planning every single time How immersing yourself in uncomfortable, foreign environments shapes you into a more open-minded person—and why Max believes traveling early is one of the most underrated career accelerators The sacrifices nobody talks about when building a global company, and why finding the intersection of passion, profit, and societal impact matters more than any single factor alone

October Horror: #9 out of 31: My second Larry Fessenden movie! Wendigo (2001) - 4K UHD Blu-Ray Review ROCKFILE Podcast 881 #wendigomovie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

Episodio 39 de nuestro Unplugged. Esta semana recibimos los nuevos Huawei Pura 80 y nos dejan boquiabiertos. Huawei demostrando que sigue más fuerte que nunca y, mientras tanto, Samsung y Apple a lo suyo. Uno con el S26 Ultra en color naranja y el otro con el iPhone plegable. No tiene desperdicio. ¿Charlamos?Usa el código: RHINO para tener un 10% de descuento en toda la webEnlace a RHINOSHIELD: https://url.rhinoshield.es/i17-RHINO

Gary and Shannon kick off the hour with #SwampWatch, breaking down President Trump's surprise peace deal between Israel and Hamas and its global implications. Then, they unpack the bizarre “death by piano” tragedy at San Francisco's Condor Club. In #TechTalk, Mark Saltzman joins the show to discuss the newest wave of ads coming to your $1,800 Samsung fridge, how Meta is using your AI chats to target you with ads, and the best remaining Fall Prime Day deals. The hour wraps with a spirited conversation about America's obsession with parlays, from the rush of the win to the shame spiral that can come with gambling.

We discuss leaked renders claiming Samsung's Galaxy XR includes controllers, Samsung's Google-powered HUD glasses potentially launching next year, and Valve's next headset reportedly entering mass production; plus VRChat creators turning into birds with Quest Pro eye tracking, Meta's latest shooter adding VR support after an uproar, the first technical details of Meta's Horizon engine, Blumhouse Enhanced Cinema out now with M3GAN and The Black Phone, Meta AI data being used for targeted advertising starting in December, and a new reference to a Dual Knit Band for Apple Vision Pro.

October Horror: #7 out of 31: I have wanted to see this since it was released! Finally! The Last Voyage Of The Demeter (2023) - 4K UHD Blu-Ray Review ROCKFILE Podcast 879 #thelastvoyageofthedemetermovie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

October Horror: #8 out of 31: This was filmed and takes place in Alaska, had to see it. The Last Winter (2006) - 4K UHD Blu-Ray Review ROCKFILE Podcast 880 #thelastwintermovie #moviereview #rockfile  ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.  

Tech Talk w/ Marc Salzman: Mark Saltzman joins the show to discuss the newest wave of ads coming to your $1,800 Samsung fridge, how Meta is using your AI chats to target you with ads, and the best remaining Fall Prime Day deals.

No novo episódio do Podcast Canaltech, a conversa é sobre como inovar com inteligência artificial sem perder o olhar humano. Quem fala sobre o tema é Alessandra Karine, ex-vice-presidente da Microsoft Brasil, com 27 anos de experiência em empresas como Cisco, Accenture e AWS. Na entrevista conduzida por Elisa Fontes, Alessandra explica por que toda empresa está se tornando uma empresa de tecnologia e como líderes e profissionais podem equilibrar eficiência, empatia e propósito em meio à automação. Ela também compartilha exemplos reais de aplicação da IA no Brasil, como o projeto Redação Certa, da Secretaria de Educação de São Paulo, e iniciativas em saúde e justiça que usam tecnologia para resolver desafios complexos. Você também vai conferir: Google One de 2 TB ganha recursos avançados de IA, Samsung vai copiar Apple em cor laranja do Galaxy S26 Ultra, sugere rumor, Novo top da Samsung deve ter "mesma bateria" usada desde 2020, Ações da AMD vão às alturas após acordo com OpenAI e Activision dá COD de graça para sabotar lançamento de Battlefield 6.Este podcast foi roteirizado por Fernanda Santos e apresentado por Marcelo Fischer e contou com reportagens de André Magalhães, Vinícius Moschen, Bruno Bertonzin, Raphael Giannotti e Diego Corumba. A trilha sonora é de Guilherme Zomer, a edição de Jully Cruz e a arte da capa é de Erick Teixeira.See omnystudio.com/listener for privacy information.

This week, we have the one and only Big Fish, Adekunle Gold, on the pod. We discuss the new album, how he secured some OGs, such as Yinka Ayefele, to work on the project alongside him, and also the true inspiration behind this new project. Adekunle takes us through his thought process and unique approach from album to album, which we think makes him a true artiste versus some of your favourites. AG also offers singles some dating advice (as a married man with necessary relationship certifications) and some business advice as well. We talk about our personal favourite songs on the album, and he also drops some Easter eggs in the episode about upcoming performance dates and news to expect regarding the album, so you'd better tune in. Enjoy!!Join FK & Jola on their Samsung journey and discover the brand-new range of Samsung Foldables. Shop at https://www.samsung.com/africa_en/storelocator/Don't forget to use #ISWIS or #ISWISPodcast to share your thoughts while listening to the podcast on X! Rate the show 5 stars on your preferred app and leave a review. Share it with everyone you know. If you also watch on YouTube, subscribe, like, and leave a comment!Choose Bolden products for all your skincare needs like we do! They're available at Medplus Pharmacy locations, Nectar Beauty, Beauty Hut & Teeka4! For US, UK & Canada, shop at www.boldenusa.comMake sure to follow us onTwitter: @ISWISPodcastInstagram: @isaidwhatisaidpodYoutube: @isaidwhatisaidpodHosted on Acast. See acast.com/privacy for more information. Hosted on Acast. See acast.com/privacy for more information.

TOWER OF SORA - 10.06.2025 - #882 Take the Survey: https://tiny.cc/cc881 BestPodcastintheMetaverse.com Canary Cry News Talk #882 - 10.06.2025 - Recorded Live to 1s and 0s Deconstructing World Events from a Biblical Worldview Declaring Jesus as Lord amidst the Fifth Generation War! CageRattlerCoffee.com SD/TC email Ike for discount https://CanaryCry.Support   Join the Canary Cry Roundtable This Episode was Produced By:   Executive Producers Anonymous*** Sir Jamey Not the Lanister*** TDL Prez*** Sir LX Protocol V2 Baron of the Berrean Protocol***   Producers of TREASURE (CanaryCry.Support) Sir Kullen Anderson Hobo of the America's, Shawn H, Malik, Sir Marty B Knight of the Bass   Producers of TIME Timestampers: Jade Bouncerson, Morgan E Clankoniphius Links: JAM   NEPHILIM UPDATE/ALIENS 4:08 ‘Alien' DNA found inside humans — it was inserted into our genes, bonkers new study claims Sora Ai maga messaging   AI PSYCHOSIS 43:42 Sora 2 invite only Sora 2 is beginning of new era Sora 2 will create massive distrust in society, “don't trust, verify” AI actress Sponge Bob Attack on Titan   AI/SPACE/QUANTUM 1:47:57 Clip: Jeff Bezos on data centers in space to power AI (X) → Data centres in space? Jeff Bezos says it's possible (Reuters) → July 2025: A quantum computer goes to space (Science News) → Scientists finally prove that a QC can unconditionally outperform classical computers (Phys)   DRONES 1:50:42 Clip: Drone show gone wrong as fire falls from heaven (X)  → Clip: More footage of drones going down in China (X)   BEAST SYSTEM 1:58:35 Samsung brings ads to US fridges (Verge)   VOICEMAIL: Anthony H 2:18:42 JOnathan F - Coffee LOFI jingle   EXECUTIVE PRODUCERS 2:04:06 TALENT/TIME 2:21:12 END 2:43:42    

What's shakin'? I went all in today with someone who truly understands the evolution of digital marketing — John Sampogna, co-founder and CEO of Wonder Sauce, a creative agency behind some of the most innovative brand stories out there. John's worked with massive names like Samsung, Brookfield, and Subway, and been featured in outlets like CNBC, Yahoo, and Digiday — but what really stood out in this convo was his honesty about what makes modern marketing work. We dug deep into the difference between branding and marketing, how companies get lost chasing performance metrics, and why storytelling and authenticity still reign supreme. John also dropped major insight on how AI is transforming the creative world — not replacing creators, but enhancing them. We even got into how his team uses AI responsibly to make campaigns smarter, faster, and more human. This one is for every entrepreneur, marketer, and creator trying to navigate the new digital frontier. If you've ever felt overwhelmed by “hustle culture” in marketing or wondered how to stand out in a noisy world, this episode is your playbook.We Meet: John Sampogna, Chief Executive Officer and Co-founder of WondersauceConnect:Connect with Rick: https://linktr.ee/mrrickjordanConnect with John: www.wondersauce.comSubscribe & Review to ALL IN with Rick Jordan on YouTube: https://www.youtube.com/c/RickJordanALLINAbout John: John Sampogna is the Chief Executive Officer and Co-founder of Wondersauce, an agency specializing in brand storytelling, paid media, e-commerce, and digital experiences. With over 15 years of experience in digital marketing and advertising, Sampogna has created and led work for a wide range of clients from innovative startups to household names such as Samsung, Scott's, Brookfield, Golf.com, and Subway, amongst many others. Featured early in his career in Business Insider's “30 Most Creative People In Advertising Under 30”, Sampgona's insights have been featured in numerous media outlets, including Glossy, Adweek, CNBC, Medium, Yahoo, and Digiday. Today, he manages a team of over 100 creatives, strategists, producers, and technologists at Wondersauce, and is well-regarded industry-wide for his innovative approach toward digital marketing and brand storytelling.

This month's episode of Brand New World was largely created during Fast Company's Innovation Festival, which was held in New York City in mid-September.    So, we're bringing you my interview with Bozoma Saint-John, former chief marketing or brand officer at companies including Netflix, Uber, and Beats by Dre—who also just happens to star on The Real Housewives of Beverly Hills. She's also the cohost of NBC's newest reality show On Brand with Jimmy Fallon, where 10 everyday people compete to have their advertising ideas actually used by major brands like Samsung, Dunkin', Southwest, Captain Morgan, and Therabody.    But first, I had the chance to tap into my inner pizza nerd and talk to founder Tom Gozney about content and design as pillars of his brand's success, how he's working to maintain the brand's culture amid international expansion, and more. (WHICH BRAND?)   Pizza and reality TV? Let's gooooo.

Antony “Skarred Ghost” Vitillo—legendary XR blogger, developer, and authentic voice of the immersive tech world—joins Charlie Fink, Ted Schilowitz, and Rony Abovitz for a sharp, candid take on why spatial computing keeps breaking hearts (and bank accounts). Vitillo, calling in from Torino (and Nutella country), takes listeners inside his evolution from reluctant Twitter handle-user to one of the industry's essential critical thinkers. With 30,000+ social followers and nearly a decade at the helm of the Skarred Ghost blog, Tony has borne witness to every device cycle, product hype wave, and reality check XR can muster.The hosts open with news that captures the collective whiplash of the sector: Samsung finally names its long-awaited “Moohan” headset the Galaxy XR; Apple is reportedly pivoting away from Vision Pro follow-ups in favor of pursuing AI smart glasses, chasing the hardware trend Meta has tried to lead—with several Magic Leap alumni shaping both companies' next moves. Meanwhile, OpenAI's Sora 2 outpaces Google's Veo 3 in text-to-video generation, and “AI feeds” continue to spark debates about separating synthetic from real in our content streams.Guest HighlightsVitillo unveils XR truths learned the hard way:From accidental blogger to “Master Yoda”: Tony's accidental rise began with an anonymous Twitter handle, a failed AR/VR startup, and a mentor's advice to “own” XR expertise—eventually outlasting the startup itself.The real cost of authenticity: European sensibilities (practical, cost-effective, resistant to Silicon Valley bombast) shaped Tony's on-the-ground verdicts: the Google Glass era was “too early,” even good implementations often wither outside logistics and niche use-cases.Product vs. Prototype and the patience gap: Tony, Rony, and Ted all agree: too many XR launches are rushed by investor pressure from prototype to product, skipping the long, hard path of patience. Meta's Quest Pro is called out as a textbook “rush job” that failed to meet real readiness.Why XR is “harder than Mars:” Decades and $150B+ spent, yet still no universal hit. Tony argues the impossible form factor challenge (stuffing room-scale computation into eyewear) is compounded by deeper neuroscience—humans simply recoil from something too “in your face.” Physics is tough, but brains and social norms are the real brick wall.Why Roblox, not VRChat, “won” the metaverse: Most of the sector's big dreams faded back to mobile during and after Covid. With Rec Room, VRChat, and others all scaling back, Roblox's mass adoption proves device accessibility outweighs idealism. Tony expects cycles of platform hype, but says only rare combinations of luck, timing, and use-case ever sustain an audience.News Highlights Samsung's “Moohan” headset renamed Galaxy XR—signaling mainstream branding push into the AR/VR hardware race.Apple shifts Vision Pro focus toward AI smart glasses—pivot after slow sales and sector criticism, echoing Meta's latest headset push.OpenAI Sora 2 outpaces Google's Veo 3—AI video generation heats up, new feeds spark debates over AI vs. real content in social media.XR product launches called out for impatience—Meta's Quest Pro and others critiqued as rushed from prototype to product.Thanks to This Episode's SponsorsZappar's Mattercraft - 3D web development with AI assistant for real-time design and debuggingViture XR Glasses Luma Series - 52-degree field of view, 152-inch virtual screen for mobile gaming Hosted on Acast. See acast.com/privacy for more information.

October Horror: #6 out of 31: I have never seen this early Mike Flanagan movie, let's dive in!   Hush (2016) - 4K UHD Blu-Ray Review ROCKFILE Podcast 878 #hushmovie #moviereview #rockfile    ~ You can subscribe to my podcasts on Podbean, Spotify, Apple Podcasts, iTunes, Amazon Music/Audible, Google Podcasts, YouTube, iHeart Radio, Pandora, TuneIn, Alexa, Player FM, Samsung, Podchaser, Stitcher, Boomplay, Overcast, Pocket Cast, Castro, Castbox, Podfriend, Goodpods, Deezer and more. ~ -Social Media Group:  https://www.facebook.com/groups/rockfilesroom -Official Website:  https://therockfile.com/ -YouTube channel:  https://www.youtube.com/@rockfile -Interview Archive:  https://therockfile.com/Interviews/    ~ Music from #Uppbeat https://uppbeat.io/t/enrique-molano/ants-carnival License code: IV5M5EGLBEBSNUDV  ~ Note: the static pictures in my movie reviews are NOT screen captures. I am not set up to do that yet but one day I hope to be.

video: https://youtu.be/GWF9d5CDF9g Sponsored by Sandfly Security: the revolutionary agentless platform designed for Linux. Visit https://destinationlinux.net/sandfly to experience security that's not just effective but gives you peace of mind. No agents. No downtime. Just cutting-edge protection. In this episode of Destination Linux, the team dives into global privacy laws and how the UK's proposed child protection and filtering systems could reshape the internet as we know it. Ryan breaks down Google's latest developer decree that threatens the very existence of F-Droid and other open-source Android app stores, while Jill takes us on a nostalgic journey through her boxed Linux collection—from Red Hat 5 to Corel Linux and Mandrake 7.0. Nate wraps things up with a look at Samsung's bizarre decision to push advertisements on $1,800 smart refrigerators. Privacy, history, and a little bit of corporate absurdity all collide in this week's show. Forum Discussion Thread (https://destinationlinux.net/forum) Download as MP3 (https://aphid.fireside.fm/d/1437767933/32f28071-0b08-4ea1-afcc-37af75bd83d6/14fee361-101b-4f8f-834b-68c94975eedc.mp3) Support the show by becoming a patron at tuxdigital.com/membership (https://tuxdigital.com/membership) or get some swag at tuxdigital.com/store (https://tuxdigital.com/store) Hosted by: Ryan (DasGeek) = dasgeek.net (https://dasgeek.net) Jill Bryant = jilllinuxgirl.com (https://jilllinuxgirl.com) Michael Tunnell = michaeltunnell.com (https://michaeltunnell.com) Chapters: 00:00:00 Intro 00:02:58 Update on Michael & The Two-Week Hiatus 00:05:12 Community Feedback: UK Privacy Laws & Router Control 00:23:09 Sponsor: Sandfly Security 00:25:30 Is Google Killing F-Droid? Android's Open Source Dilemma 00:43:18 Jill's Treasure Hunt: Unboxing Classic Linux Distros 00:45:50 Red Hat 5.0 Hurricane: The Shift from UNIX to FOSS 00:53:29 Corel Linux OS: Industry Graphics and the Wine Breakthrough 01:07:29 Linux Mandrake 7.0: The Distro That Detected Your Sound Card 01:15:06 Treasure Hunt Wrap Up 01:15:35 Samsung's Ad-Riddled ,800 Refrigerator 01:40:44 Over Time 01:41:44 Support the Show 01:43:35 Outro 01:44:36 Post Show Links: Community Feedback https://destinationlinux.net/comments (https://destinationlinux.net/comments) https://destinationlinux.net/forum (https://destinationlinux.net/forum) Sandfly Security https://destinationlinux.net/sandfly (https://destinationlinux.net/sandfly) Is Google Killing F-Droid? Android's Open Source Dilemma https://f-droid.org/en/2025/09/29/google-developer-registration-decree.html (https://f-droid.org/en/2025/09/29/google-developer-registration-decree.html) Samsung's Ad-Riddled ,800 Refrigerator https://fortune.com/2025/09/19/samsung-family-hub-refrigerators-advertisements/ (https://fortune.com/2025/09/19/samsung-family-hub-refrigerators-advertisements/) Support the Show https://tuxdigital.com/membership (https://tuxdigital.com/membership) https://store.tuxdigital.com/ (https://store.tuxdigital.com/) Special Guests: Nathan Wolf and Wendy Hill.

Today's blockchain and cryptocurrency news  Walmart-owned OnePay to launch bitcoin, ether trading and custody on mobile later this year Samsung expands Coinbase partnership in US Shibarium preps bridge restart and user refunds after $4 million exploit ###Gemini Card Disclosure: The Gemini Credit Card is issued by WebBank. In order to qualify for the $200 crypto intro onus, you must spend $3,000 in your first 90 days. Terms Apply. Some exclusions apply to instant rewards in which rewards are deposited when the transaction posts. This content is not investment advice and trading crypto involves risk. For more details on rates, fees, and other cost information, see Rates & Fees. The Gemini Credit Card may not be used to make gambling-related purchases. Learn more about your ad choices. Visit megaphone.fm/adchoices

Crypto News: Bitcoin pumps to over $123,000. Samsung taps Coinbase to bring crypto to more than 75 million Galaxy users. Walmart-owned OnePay to launch bitcoin, ether trading and custody on mobile later this year.Brought to you by

https://rhr.tv/stream - coinbase partners with samsung https://www.coinbase.com/blog/Samsung-taps-Coinbase-to-bring-crypto-to-more-than-75-million-Galaxy-users - nostrtv appletv beta https://primal.net/e/nevent1qqsqk2fhnl86vf0fhxlcdqneh5qgsw2cvzduw34s7mgs88g5nu7vqzce5rdre - Signal sounds alarm on potential German Gov Chat Control support https://primal.net/e/nevent1qqsr53e30jwl3y63fkzq40pdvu6m4cu2zsye4r39dd5qpc2zfvs734stdpsps - ICE raids bitcoin mine in Pyote, Texas https://blockspace.media/insight/ice-raids-bitcoin-mine-in-pyote-texas/ - 14th Wave of Opensats Bitcoin Grants https://opensats.org/blog/fourteenth-wave-of-bitcoin-grants - Saudi Arabia | Crown Prince Orders Rent Freeze in Riyadh In Saudi Arabia, Crown Prince Mohammed bin Salman has ordered a five-year freeze on residential and commercial rents in the capital of Riyadh. This follows a sharp rise in rent prices in recent years, a trend that the policy aims to curb. Violations face steep financial punishments. Property owners who violate the freeze risk fines of up to a year's rent plus compensation for tenants. And whistleblowers can earn 20% of any fines collected. While billed as relief, rent freezes are a form of price control that can often yield adverse effects. Property owners may reduce upkeep, shift investments away from housing, or demand informal payments to compensate for the loss of income. This can create shortages and deteriorating conditions, making it disproportionately harder for new or lower-income residents to find affordable housing amid the backdrop of authoritarian rule and immense digital repression. FinancialFreedomReport.org - Sparrow v2.3.0 https://primal.net/e/nevent1qqsy5awlgj30eeda3kv0flmjpsf23zaft2rmugv2kzw57874dwshsss6058qt - Coldcard Firmware Release 1.3.4Q & 5.4.4Mk4 https://blog.coinkite.com/spending-policy/ - Marmot Open Source Secure Messaging Protocol https://primal.net/e/nevent1qqs9kvauvvx7w82ft3lt6ujxhx8ksgcf39mc50mh3cv7a90kqgn7g0gt9u0qj - Shakespeare Act 2 https://primal.net/e/nevent1qqs8nsxy9yas5grstgscpvnlsz0ltwkgxseyxzwx6vfd04eme72afmqeqmctq - Hashpool live on testnet4 https://primal.net/e/nevent1qqsy88qd33qwsqw8ly8pyud2ztsa0fnhvygqgua4rm8gtc60y54knxg48k87l - Kagi releases ad free news app https://blog.kagi.com/kagi-news - https://www.opensourceecology.org/ 2:35 - Ten31 Retreat 8:40 - Dashboard 12:10 - NostrTV 13:60 - Samsung x Coinbase 17:35 - Signal EU Chat Control 23:45 - Marmot 25:60 - TikTok Larry Ellison 28:35 - ICE raids mine 32:20 - OpenSats 36:45 - HRF Story of the Week 41:15 - Software updates 1:04:10 - AI dystopia 1:11:15 - Bitcoin Debasement Trade 1:14:35 - Treasury debt & Coca-Cola 1:21:25 - Inflation 1:27:50 - Open Source Ecology Shoutout to our sponsors: Coinkite https://coinkite.com/ Stakwork https://stakwork.ai/ Obscura https://obscura.net/ Follow Marty Bent: Twitter https://twitter.com/martybent Nostr https://primal.net/marty Newsletter https://tftc.io/martys-bent/ Podcast https://tftc.io/podcasts/ Follow Odell: Nostr https://primal.net/odell Newsletter https://discreetlog.com/ Podcast https://citadeldispatch.com/

Speaker-less speakers at bankruptcy box. How did Rover's MRI go? Who drives more Krystle or JLR? Nicole Kidman's earlobes. North Korea bans anti-socialist breast augmentation. Poop collecting to use as fertilizer. Samsung plans to play digital ads on their smart refrigerators. Teenagers walking through a neighborhood are confronted by an off-duty cop. Rover hates the Hey Dude shoe brand. Hoods for ICE. More details have been released about the attack on a synagogue in Manchester. Apartment hunt update and JLR's rent increased. An off-duty cop is facing administration charges after he went to the Ryder Cip dressed in full tactical gear to get into the event. Krystle found a phone in her yard. DraftKings bets.

Samsung plans to play digital ads on their smart refrigerators. Teenagers walking through a neighborhood are confronted by an off-duty cop. Rover hates the Hey Dude shoe brand. See omnystudio.com/listener for privacy information.

Samsung plans to play digital ads on their smart refrigerators. Teenagers walking through a neighborhood are confronted by an off-duty cop. Rover hates the Hey Dude shoe brand. 

Speaker-less speakers at bankruptcy box. How did Rover's MRI go? Who drives more Krystle or JLR? Nicole Kidman's earlobes. North Korea bans anti-socialist breast augmentation. Poop collecting to use as fertilizer. Samsung plans to play digital ads on their smart refrigerators. Teenagers walking through a neighborhood are confronted by an off-duty cop. Rover hates the Hey Dude shoe brand. Hoods for ICE. More details have been released about the attack on a synagogue in Manchester. Apartment hunt update and JLR's rent increased. An off-duty cop is facing administration charges after he went to the Ryder Cip dressed in full tactical gear to get into the event. Krystle found a phone in her yard. DraftKings bets. See omnystudio.com/listener for privacy information.

HAPPY INDEPENDENCE DAY!This week's episode is very Power Puff Girl coded; FK & Jola are joined by Tosin, a Misan by Bamboo top user who's a makeup artist and business mogul. They start off chatting about moving apartments, an insane birthday night at Zaza featuring a giraffe and then tackle some very interesting dilemmas about parents prioritizing other people's feelings & wellbeing over their own children, weighing the cost of birthday gifts given and received, and the crucial choice of leaving your 9to5 to become an entrepreneur. They segue into parenting, discipline and learning life lessons on your own as a teenager. Enjoyyy this long, special, life-saving episode brought to you By Misan By Bamboo!Join FK & Jola on their Samsung journey and enjoy the brand new range of Samsung Foldables. Shop at https://www.samsung.com/africa_en/storelocator/Don't forget to use #ISWIS or #ISWISPodcast to share your thoughts while listening to the podcast on X! Rate the show 5 stars on whatever app you listen to and leave a review, share with everyone you know and if you also watch on YouTube, subscribe, like and leave a comment!Choose Bolden products for all your skincare needs like we do! Shop at Medplus Pharmacy, Nectar Beauty, Teeka4.com, Beauty Hut Africa, Cho & Zen (Abuja), Tulip Bodycare (Abuja).For listeners in areas the US, Canada, UK, and the rest of Europe, we've secured a special discount for you. Use the code ISWIS20 to receive 20% off all items on the site; www.boldenusa.comMake sure to follow us onTwitter: @ISWISPodcastInstagram: @isaidwhatisaidpodYoutube: @isaidwhatisaidpodHosted on Acast. See acast.com/privacy for more information. Hosted on Acast. See acast.com/privacy for more information.