Podcasts about ddn

What does it really mean to operate above the stack in AI? I got to chat with Moiz Kohari, VP of Enterprise AI and Data Intelligence at DDN, to explore how intelligent automation—not just raw computing—unlocks AI's full potential.Moiz broke down how DDN's AI-native intelligence layer empowers enterprises to:- Accelerate AI workflows without the infrastructure complexity- Automate real-time data operations across fragmented pipelines- And most importantly—make faster, smarter decisions with AIWe talked about:- The critical role of data intelligence in scaling enterprise AI- How DDN unifies and simplifies AI operations across industries like financial services, life sciences, and autonomous systems- The measurable outcomes—10x faster decision-making, real-time orchestration, and business transformationMoiz also shared how DDN Infinia supports everything from LLMs to agentic and multi-modal AI—driving performance, scalability, and automation without the complexity.If you're serious about moving from experimental to production AI, this one's for you.#data #ai #ddn #nvidiagtc2025 #theravitshow

Is AI success really about compute—or is it about intelligence? On The Ravit Show during NVIDIA GTC, I had a powerful conversation with Izhar Sharon from DDN, where we unpacked one of the most important (and often overlooked) aspects of AI: the intelligence layer.While many focus on raw infrastructure, DDN operates above the stack—enabling enterprises to scale AI workflows, inference, and automation with intelligence, not just hardware.Izhar and I dove into: • Why data intelligence is the real key to unlocking AI's full potential • How DDN Infinia delivers the right data, at the right time, to the right model—for faster, smarter decisions • Solving enterprise AI challenges like workflow fragmentation, latency, and operational complexity • The shift from experimental AI to real-time, autonomous decision-making at scale • Real-world results: 10x faster decisions, seamless orchestration, and measurable business impact across industriesIf you're looking to make your AI truly production-ready—without the friction—this episode is a must-watch.#data #ai #ddn #nvidiagtc2025 #theravitshow

Amanda Lee is the Vice President of Marketing, Analyst, and Public Relations at DDN, the world's leading data intelligence platform. She has 20-plus years of experience in marketing communications across AI, data intelligence, and technology ecosystems. Here, she discusses the rapid advancements in AI technology, the importance of data infrastructure, and the challenges women face in the tech industry. Key Takeaways:- How AI is revolutionizing supply chain, agriculture, and life sciences- Why data infrastructure is crucial for the success of AI models- The current state of women in tech Episode Timeline:1:30 Amanda's dogs3:15 How does Amanda keep up with all the changes in AI?4:30 Recent developments in AI that have impressed Amanda5:30 What's the hardest thing for marketers to explain to the public about AI?7:15 Is there enough data infrastructure to support AI growth?10:15 DDN's commitment to its customers12:14 AI's impact on various industries13:15 Autonomous cars17:00 Online safety issues caused by AI18:24 Challenges for women in technology This episode's guest:• Amanda Lee on LinkedIn • DDN's website Subscribe and leave a 5-star review: https://pod.link/1496390646Contact Us! Hosted on Acast. See acast.com/privacy for more information.

A.M. Edition for Jan. 9. WSJ editor Ben Fritz joins us from Los Angeles with the latest on a series of blazes that have many residents feeling like the city is “teetering on the brink of destruction.” Plus, dockworkers and port employers reach a labor deal that could avert potentially costly strikes. And Blackstone makes its latest bet on AI with a $300 million investment in DDN. Luke Vargas hosts. Sign up for the WSJ's free What's News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Plus: U.S. dockworkers and port employers reach a tentative labor deal to avert another shutdown. And, Blackstone is investing $300 million in DDN, its latest bet on artificial intelligence. Luke Vargas hosts. Sign up for WSJ's free What's News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

The wait is over! My interview with Jyothi from DDN is now live on The Ravit Show!

In this episode of Infrastructure Matters, hosts Krista Macomber, Steven Dickens and Camberely Bates discuss AI systems and data protection market development, announcements, and insights from a number of recent vendor and industry events, including: Microsoft's two new custom silicon chips designed for AI and general-purpose workloads, announced at Microsoft Ignite. Developments in the AI space, including considerations for workload placement and how AI-backed chatbots can streamline daily tasks for IT Operations. Perspective from the SuperComputing '23 show in Denver, CO, including storage vendor portfolio developments for HPC. Updates on Veeam's competitive position and strategic development coming out of its Analyst Summit in Seattle, WA. A preview of AWS reInforce.

On this episode of How to Be Fine, Kristen and Jolenta talk about the stigma of eating while watching television. Plus, they offer up advice on determining when a breakup is justified, and how to become more positive. Do you have an advice question for us? Email us at kristenandjolenta@gmail.com, or tweet us @jolentag, @kristenmeinzer, or @howtobefinepod. And if you haven't already, please join our How to Be Fine (formerly By the Book) Facebook community! https://www.facebook.com/groups/kristenandjolenta Sources:https://www.nytimes.com/2007/10/16/health/16well.html  https://www.ratemds.com/blog/letting-kids-watch-tv-good-eating-habits/https://blog.ochsner.org/articles/how-tv-can-help-kids-eat-healthy-foods  https://www.wellandgood.com/eating-watching-tv/#:~:text=%22For%20my%20clients%20who%20look,watching%20something.%22%20  https://mashable.com/article/binge-watching-health-effectshttps://www.redbookmag.com/body/health-fitness/news/a20046/there-are-serious-health-benefits-to-staying-in-and-watching-tv/https://www.prevention.com/health/a40107617/watching-less-tv-can-reduce-heart-disease-risk-study-says/  https://www.ndtv.com/food/pay-attention-to-food-here-are-bad-eating-habits-you-need-to-quit-1746095https://wp.wwu.edu/eatingandreading/lettuce-discuss/#:~:text=Meal%20memory%20is%20how%20well,their%20brain%20from%20the%20mealhttps://ijbnpa.biomedcentral.com/articles/10.1186/1479-5868-10-58https://www.health.harvard.edu/blog/distracted-eating-may-add-to-weight-gain-201303296037https://www.lakanto.com/blogs/food-nutrition/mindless-distracted-eatinghttps://www.hollywoodreporter.com/tv/tv-news/study-tv-feel-lonely-51511/https://www.moroccoworldnews.com/2022/09/351497/study-watching-tv-during-meals-disrupts-kids-cognitive-developmenthttps://www.chop.edu/news/health-tip/language-development-talking-not-just-your-child#:~:text=It%20turns%20out%20that%20the,matter%20the%20family's%20socioeconomic%20statushttps://ec.europa.eu/eurostat/web/products-eurostat-news/-/DDN-20180706-1https://www.census.gov/library/stories/2023/06/more-than-a-quarter-all-households-have-one-person.html

ob Zukis is a man on a mission to improve the ability of corporate America to succeed in a complex digital world, even when under constant cyber attack. Bob is the CEO and founder of the Digital Directors Network, the global pioneer in helping corporate directors advance their understanding of systemic risk. We consider Bob to be the world's leading advocate for improving cybersecurity governance. His many articles published in major business journals and impactful books on the topic make this case well. Bob has worked with, studied, and been on corporate boards for years and now teaches corporate governance as an Adjunct Professor of Management at the USC Marshall School of Business. He is co-author of the book The Great Reboot. We examine the book and Bob's approach to helping corporate directors mitigate cyber risk in this OODAcast. Topics covered include: How the 1200 strong members of the Digital Directors Network collaborate together to seek to reduce systemic risk. The creation of the Qualified Technical Expert (QTE) program and how the need for QTEs on boards is analogous to the need to have a Qualified Financial Expert (QFE) on boards when Sarbanes-Oxley drove that requirement. The new SEC regulations on cybersecurity that will require corporate boards to designate cybersecurity experts. How the new US Cybersecurity Strategy is helping create positive momentum in corporate America (Bob says "the White House has declared war on systemic risk with this strategy"). Actions directors can take to ensure corporate management is appropriately engaging to mitigate not just cyber attacks against the company, but broader systemic risks. Bob explains that "It's not just enough for board members to ask questions on cyber risk, as the questions are meaningless if corporate directors don't understand the answers." Very well put! Board members should continuously seek to improve their ability to understand. And then on top of that should ask the right questions. What is Bob's view of a powerful question boards should be asking? " What's the value of what we are trying to protect, and how safe is it for what we're spending?" Bob provides information on an event that brings together the Digital Directors Network called Domino (16-17 May 2023 in Chicago). This is a gathering of 200 of DDN's corporate director, CIO and CISO members for a unique executive learning experience. This year's event will feature keynotes from experts like SEC Commissioner Jaime Lizarraga explaining the new cyber rules being rolled out by the SEC. For more see: The Great Reboot The Digital Directors Network Bob Zukis on LinkedIn DDN Domino 16-17 May 2023

Mind Set, Tool Set, and Skill Set position you to be impactful says my next guest Daphne E. Jones. She utilizes all three game-changing ideas to stand out and overcome the thought that you are not good enough to succeed in your chosen field. Jones empowers the underserved, undervalued, and overlooked by not listening to people who put limits and labels on you. She is a head, heart, and gut leader who asks “Do you know the business” “Are you strategic?” “How much do you care, and do you have empathy and compassion?” Challenging the status quo with emotional intelligence and intellectual curiosity by making the complex simple Jones values unique experiences and perspectives to help her community grow.  Speak in the language of the audience that you are influencing to create alignment then you Win!  says Daphne E Jones. Learn, Do, and Transform each position on your path to change your business or career outcome. Daphne E. Jones is a seasoned executive with extensive experience implementing digital technologies to drive market growth, seamless customer fulfillment & internal efficiencies within Fortune 50 corporations. She has over thirty years of experience in general management and executive-level roles at IBM, Johnson & Johnson, Hospira (now Pfizer), and General Electric. During her tenure at GE, she served as SVP for Future of Work, SVP & CIO. She co-led a global team that defined GE's digital DNA and ran IT for $13B GE Healthcare businesses pf Product Engineering, Imaging, Ultrasound, and Post Market Product Services. Before GE Healthcare, her early career days were spent at IBM and Johnson & Johnson as executive Director, and VP of IT followed by her role as SVP & CIO at Hospira, Inc, a $5B global pharma & infusion technology company. At Hospira, she led all aspects of Hospira's enterprise, infrastructure, cyber, digital & analytics technology. Her latter career days were spent innovating with predictive maintenance, design for additive & other advanced technologies to help the business differentiate and win in the market.  Daphne serves on the board of directors for AMN Healthcare, Inc., Barnes Group Inc, and Masonite International Corp and is on the audit, compensation & governance committees. Named by Savoy Magazine, as one of the most influential AA Directors in 2021, she is a member of NACD, Accenture Cybersecurity Council, the digital director's network (DDN), and the Executive Leadership Council (ELC). She is the CEO/Founder of the Board Curators – a company that prepares senior leaders for paid board service at www.theboardcurators.com and is launching her book in Fall 2022 from McGraw-Hill entitles “ Win When They Say You Won't” Her thought leadership & experience make her a sought-after speaker on digital, DEI board development, and personal transformation. Daphne earned her MBA and BS from Illinois State University. Let us Welcome Daphne E. Jones to the Follow the Brand Podcast where we are building a 5 STAR Brand that You Can follow! https://theboardcurators.com/

En este episodio muy especial de Songmess estamos conversando acerca de lo esencial que es documentar una escena independiente con Payola Isabel, DJ y co-fundadora de Radio Red PR, y Carlos Larrieu aka DDN, director de videos musicales y documentales. Nos clavamos en la iniciativa colectiva entre músicos, DJs, fotográfos, periodistas y más para la creación de Radio Red, espacio esencial para la difusión de música y arte en Puerto Rico, interviniendo espacios, promoviendo compilados y hasta lanzando una exitosa serie de fiestas. Payola y Carlos han dirigido videos para grupos como Los Wálters, Füete Billete y Dávila 666, y nos cuentan acerca de sus aventuras y frustraciones trabajando dentro de un sistema que no valora el arte local e independiente. Las movidas nacionales son importantísimas y hoy nuestros invitados nos dan un tour de lujo por el underground Boricua. Playlist: Dávila 666, Superaquello, Manjar de los Dioses, Jazz Bandana, Gaby Chuleta y Ghetto Brothers. Radio Red Web: https://radio-red.com/ Radio Red Mixcloud: https://www.mixcloud.com/radioredpr/ Radio Red Instagram: https://www.instagram.com/radioredpr/?hl=en Payola Isabel Instagram: https://www.instagram.com/payolaisabel/?hl=en DDN Instagram: https://www.instagram.com/decontrol_video/?hl=en DDN YouTube: https://www.youtube.com/user/FlaggCash Fiebre de Cabina Compilados: https://abronsartscenter.bandcamp.com/album/fiebre-de-cabina-vol-1 Richard Villegas Instagram: www.instagram.com/rixinyc/?hl=en Songmess Instagram: www.instagram.com/songmess/?hl=es-la Songmess Facebook: www.facebook.com/songmess/?ref=settings Songmess Twitter: twitter.com/songmess Songmess Merch: via DM #BOPS Playlist: open.spotify.com/playlist/2sdavi0…22e104ff87a74e9c

Subscribe to Songmess on Spotify, Apple Podcasts, Stitcher, Google Play or SoundCloud, find us on Facebook, Twitter and Instagram, and contact us at songmessmusic@gmail.com.

Dollar Dog Night is officially back on 9/21 so we got a former Phillies usher who manned the aisles on plenty of DDNs back in it's heyday of 2008 - 2011. Usher Joe takes us behind of the scenes of being an usher during the World Series, the night the Phillies fan was tased, and the night Osama Bin Laden was killed. How Dollar Dog Night's now compare to early 2000s and some DDN hacks. (9:10 - 38:26) Gary ranks more NBA Draft prospects potential off their names including Collin Gillespie, Dyson Daniels, Jalen Duren and more. (38:26 - 44:10) Our Saudi Arabian Golf correspondent comes on to talk about the LIV Golf League, the insane money and prizes being thrown around, how long can the PGA Tour hold them from poaching their big name players, and can it work? (44:10 - 1:09:45) Then we finish with “What's Trending” including a Top Gun 2 review, top Joker, and pick 2 iconic TV's dad. Follow the podcast: The Wooderboys: @wooderboys Kyle: @kylewooderboys Gary: @CoachGaryPHL

Wie gelingt ein guter Generationenmix? Wie führe ich altersdiverse Teams richtig? Das ist das Thema im Teil 8 unserer Podcastreihe "Was liegt an?". Die Podcastreihe mit Nils Schmidt und Anne Sengpiel. Das Gespräch unter Kollegen. Wir streifen Themen, die in der Luft liegen und Führungskräfte beschäftigen, tauschen Informationen aus und sagen unsere Meinung – leicht konsumierbar als Einstimmung auf Deine Arbeit - wo immer Du bist. Nils Schmidt ist Vorstand des DFK. Anne Sengpiel ist Expertin für Führungswissen und Autorin für Unternehmensgeschichten und spannende Unternehmerbiografien. Mehr zum Podcast: http://podcast.dfk.eu Haben Sie Fragen oder Anregungen? podcast@dfk.eu Mehr zum Verband: https://www.dfk.eu Wir sind der Verband für Fach- und Führungskräfte - und gerade in dieser schwierigen Zeit sind wir für unsere Mitglieder da.

AATSports's Monday show is being enhanced with the addition of new co-host JD from DDN! Chip and Jamar talk about all things Sports, life, celebrations, and who knows what else!! Manscaped: www.manscaped.com -20% off n FREE Shipping using code "AATBirds" Statement Games: www.statementgames.com -Fun FREE New Look at Fantasy Sports -sign up: https://www.statementgames.com/ La Touraine Watches: www.la-touraine.com -Use code AATBirds for 10% off at checkout! aatsportsnetwork.com/shop funkbrewing.com SimBull.com - sign up using the promo code AATSports --- Send in a voice message: https://anchor.fm/aatsportsnetwork/message Support this podcast: https://anchor.fm/aatsportsnetwork/support

AATSports's Monday show is being enhanced with the addition of new co-host JD from DDN! Chip and Jamar talk about all things Minshew, college football, and baseball lockout! Plus Dad's in sports who be doing too much! Manscaped: www.manscaped.com -20% off n FREE Shipping using code "AATBirds" Statement Games: www.statementgames.com -Fun FREE New Look at Fantasy Sports -sign up: https://www.statementgames.com/ La Touraine Watches: www.la-touraine.com -Use code AATBirds for 10% off at checkout! aatsportsnetwork.com/shop funkbrewing.com SimBull.com - sign up using the promo code AATSports #podadelphia #philly #sports #chipsanddish #flyeaglesfly #sixers #eagles #nfltwitter #nfl #baseballfreeagency #collegefootball #bringittobroad --- Send in a voice message: https://anchor.fm/aatsportsnetwork/message Support this podcast: https://anchor.fm/aatsportsnetwork/support

A lot has been happening in Philly sports and a lot of players don't seem to want to be here. Chip is joined by JD Oracle from DDN! Manscaped: www.manscaped.com -20% off n FREE Shipping using code "AATBirds" Statement Games: www.statementgames.com -Fun FREE New Look at Fantasy Sports -sign up: https://www.statementgames.com/... Odds Jam: www.oddsjam.com -Arbitrage Calculator and more! -Never lose a bet again! -Sign Up: https://oddsjam.com/?via=AATBirds La Touraine Watches: www.la-touraine.com -Use code AATBirds for 10% off at checkout! aatbirds.com/shop --- Send in a voice message: https://anchor.fm/aatsportsnetwork/message Support this podcast: https://anchor.fm/aatsportsnetwork/support

AI applications have large data volumes with lots of clients and conventional storage systems aren’t a good fit. In this episode, James Coomer from DDN talks about the lessons they have learned building storage systems to support AI applications. Inferencing requires terabytes or petabytes of data, often large files and streaming data. For example, autonomous driving applications generate hundreds of terabytes of data per vehicle drive, resulting in petabytes of data to ingest and process. DDN’s parallel filesystem goes a step further than NFS with an intelligent client that directs I/O to leverage all network links and storage endpoints available. Deep learning loves data, and a smart client can make the whole application faster. Because data is the biggest AI challenge today, an advanced storage solution can really help deliver AI solutions in the enterprise. Although most companies realize that finding expertise (data scientists, etc) is a major challenge, building infrastructure to support them is just as critical. Guests and Hosts James Coomer is Senior Vice President for Products at DDN. Connect with James on LinkedIn or learn more on Twitter at @DDN_Limitless. Andy Thurai, technology influencer and thought leader. Find Andy’s content at theFieldCTO.com and on Twitter at @AndyThurai. Stephen Foskett, Publisher of Gestalt IT and Organizer of Tech Field Day. Find Stephen’s writing at GestaltIT.com and on Twitter at @SFoskett. Date: 3/30/2021 Tags: @SFoskett, @AndyThurai, @DDN_Limitless

At the Casual Swinger Compound, we joined the wonderful Average Swingers, Double Date Nation and Swingfessions over New Year's Eve for 3 podcast mashups. In this episode, Tiff and Average J do their best to answer fun questions from DDN and Swingfessions. sapphicSwingers.blogspot.com https://casualswinger.com https://www.averageswingers.com https://doubledatenation.com https://swingfessions.blogspot.com/

In this bonus episode of the three masons, they introduce a new guest, Yvonne, their older sister. They extrapolate on the sexualization aspect of Santa and this time, with receipts. Links: Eurostat overview report https://ec.europa.eu/eurostat/web/products-eurostat-news/-/DDN-20180706-1 Raw numbers: http://appsso.eurostat.ec.europa.eu/nui/show.do?query=BOOKMARK_DS-053022_QID_46836636_UID_-3F171EB0&layout=TIME,C,X,0;GEO,L,Y,0;AGECHILD,L,Z,0;N_CHILD,L,Z,1;HHCOMP,L,Z,2;INDICATORS,C,Z,3;&zSelection=DS-053022HHCOMP,TOTAL;DS-053022AGECHILD,TOTAL;DS-053022N_CHILD,TOTAL;DS-053022INDICATORS,OBS_FLAG;&rankName1=TIME_1_0_0_0&rankName2=N-CHILD_1_2_-1_2&rankName3=GEO_1_2_0_1&rankName4=AGECHILD_1_2_-1_2&rankName5=INDICATORS_1_2_-1_2&rankName6=HHCOMP_1_2_-1_2&sortC=ASC_-1_FIRST&rStp=&cStp=&rDCh=&cDCh=&rDM=true&cDM=true&footnes=false&empty=false&wai=false&time_mode=ROLLING&time_most_recent=true&lang=EN&cfo=%23%23%23%2C%23%23%23.%23%23%23 https://www.euronews.com/2017/09/05/people-living-alone-europe-solo-living https://www.bbc.com/news/blogs-magazine-monitor-31461595

In this episode - join me and Wendy Weeks as we dive into all things Human Design! Now, Wendy has been on the podcast before... but for those of you who may not know her yet - Wendy is a Human Design reader and @beautycounter Senior Director! She is a fellow FNTP and I have know her several years and she is just so wonderful! I cannot wait for you to tune into this episode! As always, thank you so much for tuning in to the Wealthy, Worthy and WILD podcast! Let me know how you liked the podcast and if this episode was helpful to you, make sure to screenshot this episode and tag me (@rebellenutrition) so I can repost! Lastly, come say ‘hey’! at Rebellenutrition.com | Instagram.com/rebellenutrition. -- If you are curious about learning about your Human Design, I encourage you to enroll in my FREE course on Human Design! >> You can also enroll in my FREE Human Design Course by texting -hdcourse- to 44222! --- Also, I have an incredible deal on my social media membership - Daily Digital Nutritionist™ for wellness entrepreneurs and nutritionists. DDN provides you with done-for-you social media 'prompts' that are aimed to help you engage your audience, grow your following and generate MORE sales! To enroll now for less than $1 a day, click here! >> You can also enroll and save $20/month by texting -dailydigital- (no spaces) to 44222! If you have any questions, do not hesitate to reach out! -- Podcast Links/Mentions: Wendy Week's Website - https://weeksofwonder.com/ Wendy Week's Instagram - https://www.instagram.com/weeksofwonder/ -- Previous Podcast Episode ft. Wendy Weeks: 23. What You Need to Know Before Joining Beautycounter with Wendy Weeks | https://podcasts.apple.com/lu/podcast/23-what-you-need-to-know-before-joining-beautycounter/id1474903542?i=1000460754617 --- Send in a voice message: https://anchor.fm/rebellenutrition/message

En Chile existe el mal hábito de minimizar cualquier opinión o intento de discusión de las y los menores de edad sobre el devenir del país y lo que esperan para su futuro. Da la impresión de que las reflexiones que tienen sobre el mundo en el que viven son automáticamente inválidas por su condición etaria. ¿Qué se hace entonces? ¿Mejor que jueguen y hagan sus cosas en paz, sin contaminarse con la “política” y los adoctrinamientos de los adultos? Pero resulta que tienen mucho que decir sobre el país en el que viven, y dentro de las muchas cosas que develó el estallido social del 18 de octubre, es que desean y exigen ser escuchados en el espacio público. Quizás sea hora de cumplir de una vez por todas el mandato de la Convención de los Derechos del Niño y escucharlos, pero de verdad. En noviembre del 2019, la Facso, a través de su programa de Estudios Interdisciplinarios de la Infancia, realizó un cabildo orientado solo a niños, niñas y adolescentes desde los 4 hasta los 17 años. Según Camilo Morales, el psicólogo y coordinador de dicho estudio, el propósito fue “saber cómo ha sido para ellos la experiencia del conflicto social, cómo eso les afecta su vida cotidiana y qué les gustaría proponer para tener un país mejor” (Biblioteca del Congreso Nacional de Chile, 2019). De esta forma, y a través de papelógrafos, post-it, lápices y juegos, los niños, niñas y adolescentes tuvieron el espacio para expresar sus emociones y reflexiones. En los diversos grupos se iban repitiendo las mismas palabras, tales como “respeto, escucharse, justicia, derechos y derechos humanos” (BCN, 2019). Si nos damos cuenta, no distan mucho de lo que los adultos dicen también. Un estudio realizado por la Defensoría de la Niñez (DDN) sobre el efecto que tiene la crisis social en niños, niñas y adolescentes (2020), dilucida mejor algunas opiniones recogidas en este rango etario. Por ejemplo, dice una niña de 9 años que está “un poco enojada porque el semáforo, la banca y el basurero no les hicieron nada a los manifestantes”. En otro caso, una adolescente de 16 años de Arica, está muy feliz porque la gente por fin está dando la cara y son “los mismos jóvenes los que se ponen de acuerdo”. También está el caso de un niño migrante de 11 años que opina que los Carabineros están muy mal, porque le pegan a la gente. Una adolescente de 13 años dice que “los carabineros están matando a una persona que está protestando” e incluso un niño de 8 años se siente enojado, triste y con miedo, ya que a su papá “le cayó una bomba lacrimógena en los pies”. Nunca debemos olvidar que los niños, niñas y adolescentes se ven afectados por lo que sucede, y así como internalizan y reproducen la cultura, tienen un rol activo en la producción de significados (DDN, 2020). Todas y todos tienen una perspectiva única, en un contexto único, que habla mucho de ellas y ellos, pero también de todas y todos nosotros. No por nada las y los estudiantes saltaron los torniquetes del metro por sus padres, madres, tías, tíos, vecinas, vecinos, profesores, profesoras y sus compañeros y compañeras. Desestimar eso sería una enorme falta de respeto. Ellas y ellos quieren hablar, y es hora de escuchar mirando a la altura de sus ojos y a la altura de sus expectativas.

In this episode we celebrate our 1st podcast anniversary, thank you tribe!  We add a new word to our vocabulary, ambivert as we talk about the struggles we and others in the lifestyle are having with anxiety and depression during the pandemic.  But never fear, we end with the sexy story of a MMMF play time we had at a small house party.   A special thanks to those fellow podcasters and content creators we have met and have offered us support. Our Naughty Escapades, Room77, Club Euphoria, DDN, Spiritual Swingers. 

Steinþór Skúlason fosrstjóri SS: Sláturhúsin hafa verið í viðbragðsstöðu síðan Covid 19 farsóttin hófst en þau stóla að langmestu leiti á erlent farandverkafólk í sláturtíðinni. Flestir koma frá Nýja Sjálandi en þetta árið kemur enginn þaðan til að vinna hjá SS. Oddný Anna Björnsdóttir framkvæmdastjóri Samtaka smáframleiðenda matvæla: Ddný ræðir markmið og tilgang samtakanna og vaxandi eftirspurn eftir vörum smáframleiðenda matvæla. Vera Illugadóttir: Þægar og óþekkar smámörgæsir í Nýja-Sjálandi eru viðfangsefni Veru að þessu sinni.

Steinþór Skúlason fosrstjóri SS: Sláturhúsin hafa verið í viðbragðsstöðu síðan Covid 19 farsóttin hófst en þau stóla að langmestu leiti á erlent farandverkafólk í sláturtíðinni. Flestir koma frá Nýja Sjálandi en þetta árið kemur enginn þaðan til að vinna hjá SS. Oddný Anna Björnsdóttir framkvæmdastjóri Samtaka smáframleiðenda matvæla: Ddný ræðir markmið og tilgang samtakanna og vaxandi eftirspurn eftir vörum smáframleiðenda matvæla. Vera Illugadóttir: Þægar og óþekkar smámörgæsir í Nýja-Sjálandi eru viðfangsefni Veru að þessu sinni.

Addison Snell talks with DDN's Kurt Kuckein and James Coomer about acquisitions and expanding use cases in HPC on a special episode sponsored by DDN.

Are you a current dancer, captain, judge, or just a person that wants to know more about the DDN judging process? This is the podcast for you! Gurbani and Eshi give their experience on how to start judging, tips for teams, and some tea about topics like biting and "bad judges" among many others! Listen and let us know what you think! Follow Gurbani on Instagram at @gurbani.b and Eshi at @eshi.jay --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/gurbanib/support

Guest Carlos Richer draws on his more than 30 years in the diaper manufacturing industry to share his thoughts and expectations on how diaper manufacturers can adjust their businesses to remain viable for the return to production post COVID-19.

Carlos Richer, the founder of the Disposable Diaper Network shares his expectations for the state of the diaper manufacturing industry post COVID-19 shutdowns this week on Make It Right. Full show coming April 25

As we mentioned on our last episode, recently, at the invitation of Dave and Andi from Double Date Nation, we joined a group of podcasters for a meet and greet event called Podcaster Shinanigans at Menages in Nashville. It was a real treat to have so many varied-style podcasters together in one place so, to memorialize the occasion, we all sat around with our microphones just before the club opened and attempted to record a huge joint show, but sadly, it was an epic fail. The next day it was discovered that the whole audio file was distorted and completely unusable. The conversation was fun and interesting with fantastic observations and opinions from Euphoria Chronicles, Our Naughty Escapades and Spiritual Swingers. It was disappointing to have lost it. We were so thankful for the hospitality of DDN and Menages, and so sad to have lost the insights that we had all recorded, that last week we made a return trip to Nashville and attempted to recreate just a little bit of the lost information and ideas. In this casual, unscripted recording, we and the founders of DDN took up the same prompt that was ill-fatedly discussed by our podcaster's group, "What's so great about lifestyle clubs?" In a format very different than our typical show, the four of us got comfortable on Dave and Andi's couch, poured some drinks, pushed record, and enjoyed a great evening of relaxed conversation. We hope you enjoy this impromptu bonus episode. Merry Christmas!

Welcome to the History of Computing Podcast, where we explore the history of information technology. Because by understanding the past, we're able to be prepared for the innovations of the future! Todays episode is on the history of the Domain Name System, or DNS for short.  You know when you go to www.google.com. Imagine if you had to go to 172.217.4.196, or the IP address, instead. DNS is the service that resolves that name to that IP address. Let's start this story back in 1966. The Beatles released Yellow Submarine. The Rolling Stones were all over the radio with Paint It Black. Indira Ghandi was elected the Prime Minister of India. US Planes were bombing Hanoi smack dab in the middle of the Vietnam War. The US and USSR agreed not to fill space with nukes. The Beach Boys had just released Good Vibrations. I certainly feel the good vibrations when I think that quietly, when no one was watching, the US created ARPANET, or the Advanced Research Projects Agency Network.  ARPANET would evolve into the Internet as we know it today. As with many great innovations in technology, it took awhile to catch on. Late into the 1980s there were just over 300 computers on the Internet, most doing research. Sure, there were 254 to the 4th addresses that were just waiting to be used, but the idea of keeping the address of all 300 computers you wanted to talk to seemed cumbersome and it was slow to take hold. To get an address in the 70s you needed to contact Jon Postel at USC to get put on what was called the Assigned Numbers List. You could call or mail them.  Stanford Research Institute (now called SRI) had a file they hosted called hosts.txt. This file mapped the name of one of these hosts on the network to a IP address, making a table of computer names and then IP addresses those matched with, or a table of hosts. Many computers still maintain this file. Elizabeth Feinler maintained this directory of systems. She would go on to lead and operate the Network Information Center, or NIC for short, for ARPANET and see the evolution to the Defense Data Network, or DDN for short and later the Internet. She wrote what was then called the Resource Handbook.  By 1982, Ken Harrenstien and Vic White on Feinler's group at Stanford created a service called Whois, defined in RFC 812, which was an online directory. You can still use the whois command on Windows, Mac and Linux computers today. But by 1982 it was clear that the host table was getter's slower and harder to maintain as more systems were coming online. This meant more people to do that maintenance. But Postel from USC then started reviewing proposals for maintaining this thing, a task he handed off to Paul Mockapetris. That's when Mockapetris did something that he wasn't asked to do and created DNS.  Mockapetris had been working on some ideas for filesystems at the time and jumped at the chance to apply those ideas to something different. So Jon Postel and Zaw-Sing Su helped him complete his thoughts which were published by the Internet Engineering Task Force, or IETF, in in RFC 882 for the concepts and facilities and RFC 883 for the implementation and specification in November 1983. You can google those and read them today. And most of it is still used.  Here, he introduced the concept that a NAME of a TYPE points to an address, or RDATA and lives for a specified amount of time, or TTL short for Time To Live. He also mapped IP addresses to names in the specifications, creating PTR records. All names had a TLD or Top Level Domain name of ARPANET.  Designing a protocol isn't the same thing as implementing a protocol. In 1984, four students from the University of California Berkeley wrote the first version of BIND, short for Berkeley Internet Name Domain, for BSD 4.3. Douglas Terry, Mark Painter, David Riggle, and Songnian Zhou using funds from a DARPA grant. In 1988 Paul Vixie from Digital Equipment Corporation then gave it a little update and maintained it until he founded the Internet Systems Consortium to take it over.  BIND is still the primary distribution of DNS, although there are other distributions now. For example, Microsoft added DNS in 1995 with the release of NT 3.51.  But back to the 80s real quick. In 1985, came the introduction of .mil, .gov, .edu, .org, .com TLDs. Remember John Postel from USC? He and Joyce K Reynolds started an organization called IANA to assign numbers for use on the Internet. DNS Servers are hierarchical, and so there's a set of root DNS servers, with a root zone controlled by the US Dept of Commerce. 10 of the 13 original servers were operated in the US and 3 outside, each assigned a letter of A through M. You can still ping a.root-servers.net. These host the root zone database from IANA and handle the hierarchy of the TLD they're authoritative for with additional servers hosted for .gov, .com, etc. There are now over 1,000 TLDs! And remember how USC was handling the addressing (which became IANA) and Stanford was handling the names? Well Feinler's group turned over naming to Network Solutions in 1991 and they handled it until 1998 when Postel died and ICANN was formed. ICANN or the Internet Corporation for Assigned Names and Numbers, merged the responsibilities under one umbrella. Each region of the world is allowed to manage their own IP addresses, and so ARIN was formed in 1998 to manage the distribution of IP addresses in America.  The collaboration between Feinler and Postel fostered the innovations that would follow. They also didn't try to take everything on. Postel instigated TCP/IP and DNS. Postel co-wrote many of the RFCs that define the Internet and DNS to this day. And Feinler's showed great leadership in administering how much of that was implemented. One can only aspire to find such a collaboration in life and to do so with results like the Internet, worth tens of trillions of dollars, but more importantly has reshaped the world, disrupted practically every industry and touched the lives of nearly every human on earth.  Thank you for joining us for this episode of the History Of Computing Podcast. We hope you had an easy time finding thehistoryofcomputing.libsyn.com thanks to the hard work of all those who came before us. 

Welcome, honored guest, to the House of Black Lanterns. How can we make you comfortable? ----- Track: Variatio 2 a 1 Clav. Artist: Kimiko Ishizaka Album: The Open Goldberg Variations Link: http://freemusicarchive.org/music/Kimiko_Ishizaka/The_Open_Goldberg_Variations/KIMIKO_ISHIZAKA_-_Goldberg_Variations_BWV_988_-_03_-_Variatio_2_a_1_Clav__44k-24b   Track: Princess Cheese Burger Artist: Komiku Album: Poupi's incredible adventures ! Link: http://freemusicarchive.org/music/Komiku/Poupis_incredible_adventures_/Komiku_-_Poupis_incredible_adventures__-_48_Princess_Cheese_Burger   Track: Antipatico Artist: J Hacha De Zola Album: Antipatico Link: http://freemusicarchive.org/music/J_Hacha_de_Zola/Antipatico_1380/Antipatico Main theme: “Hoof, Heart, & Hiss” by Matt Weber http://mattwebersmusic.wordpress.com/   Find us online at: http://thechimera.space http://twitter.com/chimerapod http://facebook.com/chimerapod itsthechimera@gmail.com   Josh Hall-Bachner: http://twitter.com/charlequin Braden Lamb: http://twitter.com/bradenlamb Jeffrey Bard: https://www.ashesofcreation.com/ Kacey Smith: [stand in front of a mirror at midnight and call her name three times] Kelly Weisman Asprooth-Jackson: https://firstparishbeverly.org/about-us/minister/ Vin LaBate: http://twitter.com/mrreciprocity and also http://twitter.com/rarecandypod

http://www.thebjjmentalcoachpodcast.com/wp-content/uploads/2019/07/bjj_mental_podcast_E61-01.jpg () Andre “Dedeco” Almeida is a fifth-degree black belt serial entrepreneur. Besides being the co-owner of the New England United BJJ Team, he is the co-founder of Origin USA, along with Pete Roberts, our guest from episode number five, and MOST recently the co-owner of DDn’Co LifeStyle Clothing Brand. He shared his early days teaching in Brazil then eventually the tough transition to the United States and also about partnerships in business, which inspired me to title this episode MAKING A BUSINESS PARTNERSHIP WORK. Stick around for my final thoughts after the interview when I expand on the topic and share with you 7 Tips for Making a Business Partnership Work. Subscribe, rate, and review the podcast! I would love to hear your feedback about the show; you can reach me at info@thebjjmentalcoach.com Enjoy the podcast! OSS! Gustavo Dantas The BJJ Mental Coach – https://tinyurl.com/y2pen9gx (https://tinyurl.com/y2pen9gx) Itunes – https://tinyurl.com/y45kymp4 (https://tinyurl.com/y45kymp4) Google Plus – https://tinyurl.com/ydetberf (https://tinyurl.com/ydetberf) Stitcher – http://tinyurl.com/y52f5u6z (http://tinyurl.com/y52f5u6z) Sources: DDnCo Lifestyle Clothing Brand – https://www.ddnco.com/collections/ddnco (https://www.ddnco.com/collections/ddnco) Origin USA – https://originmaine.com (https://originmaine.com) Book – https://www.amazon.com/Start-Why-Leaders-Inspire-Everyone/dp/1591846447/ref=sr_1_1?crid=3DWUL3M3BAYBH&keywords=start+with+why+simon+sinek&qid=1563320725&s=gateway&sprefix=start+with+why%2Caps%2C182&sr=8-1 (Start with why (Simon Sinek)) Podcast – https://handsanddaylight.com (Hands and Daylight Podcast)

Mit Martina Schmeink, der Geschäftsführerin des Demographie Netzwerkes rede ich darüber, wie sich Unternehmen optimal auf alternde Belegschaften einstellen können. Wie gehen andere Firmen mit dem demographischen Wandel um und wo steht das eigene Unternehmen im Vergleich? Diese und weitere Fragen stehen im Mittelpunkt beim bundesweiten Demographie Netzwerk e.V. (ddn). In dem gemeinnützigen Netzwerk von Unternehmen für Unternehmen haben sich rund 300 Unternehmen und Institutionen mit einer Personalverantwortung für über zwei Million Beschäftigte zusammengeschlossen, um den demographischen Wandel aktiv zu gestalten.

That would be nice... an EU Wide Minimum Wage. Maybe it wouldn't be? At least not exactly as the S&D have previously said would be good. Support us on Patreon! WE HAVE A T-PUBLIC STORE what a fashionable way to support our podcast We now have a website that you can find here! Feel free to send us an email at PreviouslyInEurope@gmail.com or follow us on Twitter @PrevInEurope If you can please leave us a review on Apple Podcasts and if you can't do that tell a friend, this stuff really helps us out Also, have you considered Matteo Renzi? That would be nice... an EU Wide Min Wage At a public debate in Warsaw, Poland, Mr Timmermans said: "We need a minimum wage in the European Union. "Equal to 60 percent of the median wage in every member state, I mean." this factcheck from Euractiv is terrible https://www.euractiv.com/section/eu-elections-2019/news/fact-check-is-equal-eu-minimum-wage-possible-as-bulgarian-socialists-claim/ doesn't go into supposed policy or really where the calculations are coming from really (there's or the BSP) Macron is talking about it https://news.un.org/en/story/2019/06/1040251 Merkel is talking about it (kinda) https://www.politico.eu/article/german-chanellor-angela-merkel-calls-for-comparable-minimum-wage-across-eu/ Italy has a sectoral collective bargaining system involving unions meaning there's a minimum wage but it differs from industry to industry (the lowest is agriculture at 874.65p/m or 5.47p/h) Austria has a sectoral collective bargaining system as well, but a minimum has been set by these collectives (1500p/m) and you also get 14 monthly paychecks (holiday bonus and Christmas bonus) this results in an effective hourly minimum wage of 14.20p/h before tax Cyprus has a set of different minimum wages for certain situations. These were set by the government but don't cover everything. Sweden has a sectoral collective bargaining system involving unions Denmark has a sectoral collective bargaining system involving unions Finland has a sectoral collective bargaining system involving unions Some official stats from Eurostat: https://ec.europa.eu/eurostat/web/products-eurostat-news/-/DDN-20190131-2 (general levels) https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Minimum_wage_statistics&stable=0&redirect=no#Minimum_wages_expressed_in_purchasing_power_standards (scaled for PPS) PPS definition https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Glossary:Purchasing_power_standard_(PPS) An unexpected smart thing from New Labour? So the UK introduced theirs in 1998 at a now hilariously low £3.60 gradually increasing over time. The economist even thought this very low rate was probably just fine as it wouldn't really impact anything directly unless the Bank of England did something in response https://www-economist-com.libproxy.kcl.ac.uk/britain/1998/06/18/unveiled They've just progressively been increasing it over time... not enough almost certainly but it was a good way to get the lever on the books. I dunno maybe?

Se ouvires vais: Saber o que ter uma baguete na pelve; Saber o que se passa com o DDN; Conseguir enunciar a Teoria de Blank-Planck; Receber um ferro de engomar se ouvires até ao final.

DdN is winnaar van de Haarlemse DJ contest 2018. Inmiddels draait hij regelmatig in de regio. 12 april liet hij op Haarlem105 horen waarom.Set gemist? Gelukkig kan je 'm terugluisteren!

Matt interviews Jessica Robertson while at SYNC 2019. Her first career was a high school teacher, which is something Matt and Jessica have in common. They both loved working with that age group and still do. And they both love teaching (and learning), which is why they love to share what they know with the industry. Storytelling and collaborating with clients is what is working for Jessica. Listen in to find out more about how she does that. And don’t miss what she’s excited about in the industry now. You’ll also want to hear how Jessica overcame her fears when she first started… and how she stays in business now. Jessica’s advice on what to spend money on is based on where you are in your career, which is great. The best advice she ever received she uses on a daily basis and you’ll want to too. Book: Rachel Martin: What to Say Online Resources: (http://www.jessicarobertson.com/) (http://www.jessicarobertson.com/for-photographers) (https://www.facebook.com/groups/630336874012039/) – Shoot it Straight with Jessica Roberton   (#) Transcription was done by Temi.com which means it’s an AI generated transcript. The transcript may contain spelling, grammar and other errors, and is not a substitute for watching the video.   [00:01] Hi, this is Jessica Robertson and you’re listening to from nothing to profit. [00:05] Welcome to from nothing to profit a photographer’s podcast with Matt and Kaia where each week they talk to photographers about what is working in their business now so you can swipe those ideas and grow your business faster. [00:21] Hey everybody. So Matt here and I’m going to, I’m recording another podcast from sync without Kaia. Maybe next year we can all convince Kaia to come back here. She comes every year, which didn’t come this year. And so go ahead and just send her an email and let her know she has to come next year. Anyways, I’m, my guest today is Jessica Robinson, so I don’t know much about you because we don’t run in the same, I know we don’t, we don’t, we don’t, we don’t run in those same circles. We should. We should. We will. We will from now. But I just saw Jessica speak at sink and I was blown away by what you guys are doing. So I don’t want to steal your flame cause you already liked did your speech and so you can just tell everybody those slides again if you want. But I’m going to do it from start to beginning. Sure. Um, so tell, tell us real quick about your studio, what you guys are doing and all that stuff. [01:09] Sure. So our studio was in Ashland, Virginia, just outside of Richmond. We photograph about 200 seniors a year in addition to some families and babies and some corporate work that we do. I started out of my home originally or I started on location really and then to my home. And then we opened our retail space in 2005. Um, our first studio was about 1500 square feet and we lived across the street because the street that you want to be on in our small town. And um, now we have a 3000 square foot studio and that’s been since 2011. I have a fabulous team that works with me. I’m very fortunate to have, um, Karen and Robin support me and help me so that I’m able to really do the thing that I love, which is photography. Yeah. [01:46] Yeah. And then they’re here this week at sync with you as well. They’re really awesome people. So you are, let me just tell you, you are lucky. [01:52] Oh, I’m so fortunate. I’m so incredibly wishing. Just have this whole podcast and just talk about them as what we should really, really, I mean it’s not really mean, let’s be honest. I just do what I’m told. I, I say that all the time and it’s DDN again, so you can you tell me this, I’m like, ah, I don’t really know. Ask Karen and Robin. I just do what I’m told to Support this podcast

Dr. McKenna has successfully treated an incredible array of diseases, inside and outside of orthopedics with stem cells. McKenna has been on the front line of stem cells and their clinical application for decades. If you have ever wanted to know the vast array of proven applications for stem cells, do not miss this episode. What stem cells are, how they work, where they are and are not taken from, why cord blood and PRP are NOT the same as stem cells technology used today, the issues of the FDA, his association with RMI (Riordan, McKenna Institute for stem cells with Neil Riordan), treating Mel Gibson and other celebs & lawmakers, the future of research in stem cells, why all SC healthcare providers are not practicing equally (or ethically), why Panama & the Bahamas are used for advanced stem cell therapy and more.https://TheCellSpa.comhttps://drwademckenna.comAtrantilhttps://lovemytummy.com/spoonyProlon Fastinghttps://prolonfmd.com/isreferral.html?p=KBMD&w=FMDhttps://kbmdhealthhttps://gutcheckproject.comHey hi Mandy if you don't know me it's probably because I'm not famous but I did start a men's grooming company called Harry's the idea for Harry's came out of a frustrating experience I had buying razor blades most brands were overpriced overdesigned and out of touch and here is our approach is simple here's our secret we make sharp durable blades and sell them at honest prices for as low as two dollars each we care about quality so much that we do some crazy things by world-class German blade factory obsessing over every detail means were confident in offering 100% quality guarantee millions of guys have already made the switch to Harry's so thank you if you're one of them and if you're not we hope you give us a try with the special offer get a Harry starter set with a five blade razor weighted handle shave gel and a travel cover all for just three bucks plus free shipping just go to Harry's.com and enter 5000 at checkout that's Harry's.com code 5000 enjoy all life we are here with a gadget project this is episode number seven on marriage for you here with your host Dr. Kendra I was going on today good morning good morning how you doing I am doing well how are you doing this more well than what I am on the day number four of the fasting mimicking diet how about you I am also on day four the fasting mimicking diet made by prolonged made by prolonged so I want do a shout out to Dr. Joseph onto the CEO prolonged and Dr. Walter Longo who wrote the longevity diet they sent us some prolonged kits and were given a shot the fasting mimicking diet they are it is the fasting mimicking diet so I am comparing it to a previous experience of doing a water fast it's very interesting and this is far more tolerable quite honestly and just this morning I did check key tone levels I was it 2.2.1 date date three you're supposed to start doing it so by as this day goes on you probably start kicking up a whole lot more yeah so I found that to be beneficial it's only falling in line with what you want I did comparing this to a water fast at this point I was big meal for being in three nap days I feel like I was really ready to start eating the by day four that was enough for me I did dad it four full days of the water fast but with Pro line I feel actually feel really really good it's not too bad it is nice the way they can portion out every days meals what were going to be eating so my wife's doing with this also the only hard part was it earlier this early this week I had to cook dinner for the boys because they still gotta eat and family had some nice juicy steaks to sit there and you can have any of it I couldn't do anything with it was not the box about yourself how was yours will I'm you I'm doing well this is my fourth five day fast I guess is a little over year trying to do them every few months I first want to prolong which is not a big deal all second one I did kind of my own little fasting and keep mimicking style I didn't have that what I'm in a call that burst of energy right or possibly it was stimulation of stem cells listed in that in a few minutes here and then I did a water fast only my ketones went through the roof but I was quite miserable sore back to the prolonged given this a shot and we'll talk about that in the second but I mention the stem cells today's guest while this is going to be if you know anybody to have autoimmune disease if you know anybody that has back pain anybody has joint pain to an end because we have a stem cell expert Dr. Wade McKenna orthopedic surgeon skies a bad ass in this field and we were sitting there talking just outside I'm like holy cow I'm just considering take notes like we brought in a professor of stem cells may ease size pretty amazing how he actually played football at Oklahoma State went to med school I perform indices with him several years ago whenever he was still heavily just as he is today doing orthopedics he's a fantastic surgeon all of this is led to somebody's actually can remind me you he never wants to stop learning and so it's it's led to areas where he is today and he is I would say quite the expert with stem cells and where the future is going with them so this is so exciting that we have to time to fast for this episode because you know people throw around the word stem cell a whole lot and much like the CBD industry people throw around there's lots of misinformation there's lots of quality differences the people that are actually giving stem cells there's lots of differences with that so we could clarify all of it I really feel like there's some parallels you and I have brought in several CBD experts right and there's some parallels here and so you know this is a super exciting for that anything going on with the family anything going on socially well this last week whenever Morreale moved into preparing to do this fast I would say that the boys have the have enjoyed teasing us and other than that they've they thought back into all season basketball quite busy and is kind of the every day as usual at the round Renner household self typical tennis weekend both the Lucas and Karla were playing tennis and they both did really well it was kind of a little curb although I'm really proud of my team because as working to be launching the D hat health box Dr. Lisa Alvarez actually did a little commercial for she did so yeah and so do I get a chance to pop into the set see it the move honestly try to see what that happens I appreciate her taking her time to do that so another chemical thing I just go phone with Dr. Chang Ron Houston yeah great guy fantastic functional medicine doctor he actually has ties with prolonged him and him and Joseph were friends okay to be having a huge conference coming up on April 27 were he to talk about brain got issues where you have them on the show because he's got some incredible stuff on brain waves and its affect pre-and post trauma and its effect pre-and post-diet change and using hemp dry products so super cool I just have a phone with him so to get a chance go to his Facebook page a lot of really cool information so awesome I think the work on the move and all these unique directions right but what's the big deal stenciled what we want to talk about I think that it's it's the newest new frontier it's no different than the way we've been spending time talking about CBD why why just a few years ago the revelation that you had into polyphenols and how I could do these are it's a lot of what nature is giving us to work with and it's kind of amazing that it's it's all coming to fruition nowadays and you hit on it a little bit earlier I know that the Dr. McCann is going to address it as well the FDA it many times when we want this government entity to be on our side in helping us out can really be stymieing a lot of the progress that many of the citizens could be enjoying that they could be taken party to have a better quality of life and in a really odd yet when you get down to money reason you find out that the FDA is is hard to budge out of the way in in terms of progress so interesting because what he was talking about is exactly what I've been doing so in in all fields of medicine it's very hard to change the direction of this large Titanic like shipper people doing things and we have either many ways as he said as he described it to skin a cat or really none of them really working very well sure and then when you find something it's hard to get people to pay attention to much like trying to write I mean when we sit there when we came in without her until we know that mojo and 5.0 guys are talking there really trying to tell everybody about the bloating effects with it but we know that our trenches made up of polyphenols and we know those polyphenols are really good for you they actually are the antiaging and anti-inflammatory molecules in the Mediterranean diet so we need to expand that message a little bit more rhino people hey you can take these polyphenols which are in trying to and they can actually do some of the things Duncan that stem cells do and we can talk about this in some science but if you're curious about that if you looking at upfront Hills or any place that you go where they should go to love my tummy.com Ford/spoony that's love my tummy.com/spoony and then use the code spinning Sabal cash while you pick up your own polyphenols to be delivered right to your home and then keep listen to this because you do realize that these there's lots of overlap chain runs you to be doing a brain gut thing where he shows that you need to protect your gut I'll try to help with that we got Wade McKenna here talked about stem cells the body wants to rejuvenate itself you need to give it the things that can this is going to be so excited working a really geek out today I am the earliest I want to definitely I want to hang in there because what you learn is literally some of those cutting edge stuff you meant Dearborn stem cells person to make a circuit in the news and it's really odd the way the people began to report new science and health sometimes it can be this is the greatest thing ever or it can be a lot of scare tactics in our member the first time I heard about stem cells it was the unfortunate been taken from unborn babies etc. but that's not what's happening in all when you begin to get past that layer will guess what it's just like anything else you get past the first layer and then you find that there's a whole new world to discover and in terms of what Dr. McCann is going to talk about we have lawmakers here in the US to prohibit certain strip certain lines of stem cells being used but they are still incredibly beneficial and some of the culturing over the growth of those stem cells and do what the US would state would determine to be tissues they couldn't do it here they could do in Panama and oddly enough who found his work in Panama always couple lawmakers really kind of the good kind of weird and ironic that the same people there are part of that institution it doesn't allow us to do certain things will go out of the country to get that kind help is such a small world and its fate in whatever it is I think a lot of things that have happened in both our lives have been opportunities that we take advantage of and I love you and I were working one day and I was like dude did you see that Joe Rogan we had Mel Gibson on and some other guys some PhD knew it yeah I know those guys and I was like laughing because no Gibson said the same thing a lot of people think is like you think about stem cells you have a mouth going up the side of your face and now not at all as it turns out he took his dad down to Panama and his nonmaterial dad and he got better and that's what I was like whoa and you started saying to me this is a long time you're over your half your menu go to meet my buddy Wade because he's doing a lot of the same thing same parallel paths and since it is really scientific and is just trying to get people better that's it a year of your right on and just think about that so that being at least 18 months ago I believe that Mel's dad was started going down there maybe five years ago think of the advances in the tank and the technologies that have come along with stem cell research and send that's exactly why Wade Dr. Wei McCann is here to tell us a little bit more about where it's going how you going to measure what is authentic stem cell injection what is there the right protocol what you be looking for who are the imposters there's a there's a lot of information out there it's no different than learning about CBD and where to go get the right kind of CBD of its harvest of the Rahway producer away I just think it's it stinks I went to a doctor friend of mine Dr. Marlon Padilla and we are in his office and he just are talking about I'll check this out I'm now doing stem cell know the quote you have stencil expert on this week you go take a listen easier is it Hillcrest medical and University Park area… Having super great guy very innovative himself trying new things yeah and you he started do that like that small world some sort to pay attention to all these things so one of these lectures get caught up on everything that sewer pursuer at night to geek out a little bit so how I Titus altogether how to retire fasting together how to get stem cells and how we come full circle to discuss what's out there in the literature about what were passionate about also write well it's kind interesting because what were doing with that with that diet selection are trying to heal CBD fasting and learning that stem cells you find I think for all of our listeners as well as us this is all synergistic there's a reason why we're Gerber took the mail here with this kind of message so using our graduate student that always helps us out we've got some really cool articles kinds altogether, and with what I consider really geeky stuff I want you to hang in there for me okay so the first question is your on day four of the prolonged fast why the world even doing that well it has been shown that in cellular metabolism in July 2015 summarize whatever you and will fast it promotes stress resistance so basically when you're put on a fasting mimicking diet or I should back up we've always known that the caloric restriction diet has been shown in yeast and other animals to prolong life Walter Longo in his book figure out a way that you can eat a little bit and trick your body to believe that it is completely fast that's the fasting mimicking diet is so this study in 2015 looked at putting mice on the fasting limiting diet and they demonstrated that these mice decrease the size of multiple organs improved glucose control decreased visceral fat lower blood pressure improved bone mineral density rejuvenated the immune system and reduce cancer risk always too good to be true and Academy just five days three times a year and can accomplish this but wait there's more we got more here they also showed after they re-fed the mice solicit what this is the coolest thing about this when you listen to vaulter give lectures he said it's not so much the fast it's the recovery from the fast because when they re-fed him they showed that in older mice areas of the brain like the hippocampus showed neurogenesis and improved cognitive performance while yeah so it's pretty wild with the re-feeding that super important which makes it fun because on Monday for I'm really looking to some refuted yeah can't wait for some re-creating but any that's all part of the process I will say going through at my second fast that this is becomes easier it's it's not as hard as the first run of some that's with prolonged but it is the expectation is they are know what to expect I know struggle for so what would be contributing to better neural thinking that is you a question so the question is what's going on there so then we dug up an article in the Journal of stem cell research in 2016 what they showed is that fasting protects against immune system damage and induces regeneration by waking up stem cells or by catalyzing dormant stencils so all those what they realize is what this article describing is what vulture was figuring out right there what he had figured out that all comes down to stem cells at the refuting stage basically not with her not stenciled several times which is to find what is real quick stem cells are the body's raw material their pre-sells for all other cells stem cells are the only cells that can generate new cell types and they can divide into form what are called daughter cells which become specialized cells that eventually come specific organs that's all me to say about it because wage may come in here and blow our minds until us a whole lot more with what stem cells are so for my all intensive purposes on coming here knowing stem cells can become other cells – easier to tell us way more with that so basically after you fast and then you re-feed you flip a regenerative switch which promotes stem cell regeneration in the blood making organs so that the important thing so when you go into starvation mode the body will save energy and one ways to recycle immune cells and that causes autophagy so old and sick and dying cells are programmed to hate go away right and then the autophagy gets rid of the old site sells them when you re-feed the stem cells wake up and they go around there's a bunch of fallen soldiers they don't bother them but they go around and say we need new people to replace this over simplistic way to lead into a much cooler explanation of that and then with each cycle you re-feed you get rid of sick and dying cells and replace them is like a janitor it's exactly like a janitor so five day fast three times a year you just cannot quit you just doing some serious housecleaning I member Saturn panda when he talks about that that's the godfather of circadian rhythm fasting or intermittent fasting right he's got mouse models he still does a prolonged fast because he describes it as you brush your teeth every day and then you a couple times a year you going to get the deep cleaning from the dentist I like that analogy you're always doing maintenance which is you keep in the nine date of of what you're eating but every once while you get to do that deeply definitely and then trying to fast for the first time you you can look at you like why would I not want to eat but if you look at the history of time where people were in the movement nowadays to return to health where people are trying to get healthier and you look at things like Paleolithic's for instance they talk about new diets and ways to eat in a pale lifestyle some of that also includes fasting and the reason is the primal man also went a long time without having food and for a few days at a time they would have intermittent fasting org or a few days fasting themselves yeah and so basically you're just returning to what it is that we've all been programmed to do for a long time that it just so happens the last several generations we've had ubiquitous amount of food here in the US and so now we it'll thicker bigger let's okay so this is no doubt about it feet eating is awesome right but eating is an inflammatory process so when you eat your you to become inflamed a little bit and then you incorporate the nutrients and so will the way that were doing and how will we eat so much it's probably not the healthiest way so right now where the fast let's talk about was actually a lot going on with our bodies before talk about Howard to tie all this together two stencils. So day one this is basically the five defenses what's happened to you and I so day one just upon your body day to start doing some fat burning day three start doing some cellular recycling basically you're going to clean up start realizing were on day three now for backing cavemen times they one day to that's normal day three your body starts going up oh we better get ready for something because were you have to go out and get some food soon and that's when you start doing the cleanup and this is when a lot of people will reach ketosis day for you and I right now are in this this is the cell regeneration this is where autophagy started yesterday in autophagy is when those old sick and dying cells are programmed to go away much like we talked about with the polyphenols when they get in there in your list and causes my top a G5 in the foods we eat will do that then this starts artists are stem cell-based regeneration is starting to ramp up so when people talk about how I fascinated 24 hours 09 and identity a fast we've come this far when were this far into it tomorrow's what all the real magic happens all the magic day five regeneration continues now we've turned on our stem cells and the body is being rejuvenated from with it now the first time you and I did this did this are fast I think it was tonight will this happen to both of us we both slept what two hours yeah I even so every time that a fast so far I feel great whenever I go to bed and feel really rested but don't last night that of the of my fast I basically went to bed and then I thought I woke up again as a man what a great night sleep again and I looked over the clock I been asleep for two hours and 15 minutes and then I sat around the house like what am I going to do for the rest this morning about tired right now and then later I learned that was over Rex and it was being released telling me I always forget that all Rex and O Rex and so is released from hormone release my brain saying it's time for you to go and eat and I had in them and an abundant oriented interview time for you to get up have the energy to go kill the woolly mammoth so that you can eat and you can feel it a mere year manic and it was time and you saw me run when I quit the fast I mean I think of the time I my blood sugar was 54 and and and I felt fine with that and at key tones I think for 4.8 and the moment that we drew ride today the labs and that in the blood that one time it was it's time to eat yeah so both of us have ever similar expenses this is the third day that we done this so now let a geek out here for the last four minutes because this is where I think it comes in really cool and so we found an article that has a really long title and I just like I like saying it just because I realize that this is the kind of stuff I'm reading ditto for the show treatment of periodontal ligament stem cells with Emil Warren CBD promote cell survival and Ronald differentiation via the P 13 K a K TM tour pathway that would scare most people scared me off at first but our graduate student said this is a fantastic article hundred 11 so basically what this whole article shows is you can get stem cells from a few places Dr. McKenna will explain where bone marrow fat but one of the places periodontal ligament so these are known as mesenchymal stem cells meaning that they are the least differentiated cells and they can trying to become anything so one of the important things is quality of stem cells keep that in mind because we'll talk about that coming up quality stencils so one of the things about stem cells is that there are a lot of different qualities but once you get the stem sellout you have to keep the stencil healthy so you have to keep it alive and you have to keep it in the best environment possible so there's different mediums to do this this study looked at taking stem cells out in vitro meeting in a dish and they bathed them in CBD and more range in MO R which is a program to sign a day in which is a polyphenol which is the same stuff that upfront deals made of so they they bathed them in CBD and in a polyphenol blend amazing supercool they did it for $40 and what they showed is that they demonstrated longer survival less a pop ptosis or programmed cell death decrease the M tour pathway the M tour pathways the pathway that makes cells grow right so bodybuilders lots and tour pathway but guess what cancer enter pathway also so to growth pathway increased differentiation capacity meaning they can become more of something quicker they increase nesting and DDN after which neurogenesis or new nerves new brain tissue right and then it did a deep dive into the genes that these stem cells turned on that gets into the cool epigenetic stuff that we talked about before base will have these genes so they concluded that in the field of stem cell research it may be improved by bathing them in CBD and a polyphenol mix so if you not get injected anytime soon might not be a bad idea to start from the inside using some CBD and possibly some upfront it sounds to me like the research is probably on the on the cusp ears are going into that that's why they're bathing them in the point assignment in the CBD but it's weird that just three weeks ago when we had Mark on he was talking about his D differentiated contra sarcoma test stem cells that basically were released and they didn't know exactly where to go they begin to proliferate and he even said it could be found in an organ anywhere in your body even when you feel like you taken so it's critically important that your stem cells are differentiated they get to the place they're going to be and do what you need them to do you don't want them growing out of control so maybe possibly will find on the future that combining a polyphenol set with a plant a point of sanity and CBD along with stem cell therapy would be a protocol I be awesome to get people started here or should they go to get I would eagerly for you go to K BMT health.com and go to the store you can find both are trying to heal and the new KB MD CVD or you can always go to love my tummy.com/spooning and hearing about four minutes really joined by the Dr. Wayne McKenna so if you know anybody that has joint issues back issues knee issues and take it one step further autoimmune disease there's so many things that now look into the science of stem cells that is going to be supercool to geek out and this guy knows his stuff I am excited to have youth if you had any questions about stem cells is the witness of the main unit turn to Dr. Wade McCain is going to join us here we can take a break in about 10 seconds thing wrap up now just thank you guys for the prolonged high talk Elson if you are trying to quit drinking or doing too many drugs listen to me you don't know me and will never meet I had a problem like you want I drank and used a party a little too much till he got out of control and almost ruined my life I realize I needed help to fix my problem before it totally destroyed me if you tried to fix your drinking and drug problem and you know you can't do it alone you need to call the national treatment advisors they'll immerse you into a 30 day program to replace your old habits with new habits and totally change your life and if you have PPL private health insurance the entire program may be covered fix your problem right now before it gets any worse get clean call now and learn more 800-296-1252 800-296-1252 800-296-1252 800-296-1252 it looks like you're losing I am I losing weight I am losing my lost about 10 pounds how are you doing it funny name but I done it with review zone RAD use zone.com and the stuff works it's you you get it all that the molecule this that found in that all I can tell you is it it's a it makes you feel full and he keeps your mind off of wanting to overeat and also boost your metabolism yes you're done and more guys try it today it's gonna work for you like his work for Brad and countless other people read you zone.com are IDUs owners.com fast track student loans can get your student loans out of the vault stop any wage garnishments stop collection calls and stop seizure of your tax refund give yourself a break to stop the stress and get your student loan payments down to as little as $25 a month based on what you can afford to pay 800-709-4395 800-709-4395 800-709-4395 800-709-4395 okay were back it's now the second half hour episode number seven of the gut check project we are now joined with Dr. Wade McKenna but McKenna thanks so much for coming in today really appreciate absolutely so see what I do know him yeah you know whatever no word of her Rhonda Patrick goes on Joe Rogan's economy gets better paper out you'll be taking some notes I favor Gerardi, Patrick never feels more like absolutely just a caveman. Dr. she's a lot of knowledge of sausage yellow management so you since you do already went through a couple of small things in the last half-hour you played football look on the state you been orthopedic surgeon for several years but that's not really what you here to talk about today the cool part is I actually can you hear we good we are little my problem were going to get something fixed here real quick right area is going the cool part for me they spent is kind of been allowed to reinvent myself as a traditional surgeon when the science, caught up to what we do and figure out that a lot of what we would think of as traditional medical approaches were less than optimal from patients and point so exited a fellowship in trauma and post dramatic reconstruction after an orthopedic surgery residency and after a general surgery internship so in during a general surgery internship when I thought I was going to do transplant surgery because that was the coolest guys at the hospitalists on which Trina here in Dallas Fort Worth multiple hospitals with DFW medical service rendered him orthopedic residency I did my fellowship and trauma to the general I was Roy Sanders 2000 but hospital where as to trauma fellows panorama the program we had 10 residents in for helicopters and no sleep with a whole new episode on what lack of sleep will do to your stem cells well it lack of sleep and not healthiest UW not like lack of sleep induced by fasting where you feel like Superman lack of sleep induced of note falling asleep in the boat in the lounge chair waiting for the nurse to tapping the short essays time to go from zero to hero so but during the trauma fellowship we became very adept because we got stuck with a lot of the fractures that other people treated heel so the posttraumatic part of that is acutely we were stabilizing multiple extremity injuries but we also do those people over multiple extremity injuries and we would get referred a lot of the trauma patients the gentleman traumas what we called it which comes to visit you in clinic does it come to you in the middle night by helicopter gentlemen trauma that watching your clinic is like I get this knife stuck out as well hey I've had five surgeries on my femur fracture I still can't walk and still no bonus I have is soon healed and we had to find a way to not only promote tried to trick the body and the human something that already showed didn't want to heal but in the least invasive way possible to turn the table can help the patient generate new bone best way to do that early on was Boomer us were concentrate the very Baston first uses of bone roster concentrated in traditional surgery was in the treatment of nonunion when someone has a fracture that doesn't heal there is delayed union which is means takes forever that but there's nonunion wishes means it doesn't heal there's no bone if you have a leg doesn't have a hip fracture can't walk can't but wait on it given upper extremity with an unhealed fracture pretty much flail you can you have a non-nonfunctional extremity bone rest will concentrate in the treatment protocol this allowed us to be much less invasive instead of just it doesn't make a lot of sense to just take out all the other plates and stripped the blood supply room muscle replay fracture further destroying the blood supply to the fracture that already the numbness blood supply to heal so let's go ahead and revisit that really quick because as a surgeon it's interesting to dear somebody because that's typically that's a knee-jerk reaction all that last surged and worked when he operated as exactly so say one more time with re-operating guys will here's the problem with re-operating if you didn't heal the first time it's because of the formation of scar tissue not healed tissue so the healing gets stopped the fibrotic tissue begins scar tissue hurts scar tissue does not much blood supply and scar tissue is very functional it's fibrotic it it can take up some space for the most part the difference between the interface between healthy tissue and scar tissue continues to be painful forever every time you move something severe big fibrotic knot of scar with an attendant and you have some healthy tissue that generate the connects to it the mismatch in pliability that mismatch of you would never use metals that have different hardness when you put together an engine it is the soft metal in the hard metal caused threading and corrosion in significant problems and and metal mismatch soft tissue mismatches just as big a problem we create scar tissue and people hurts generates pain generates an inflammatory response or chronic inflammatory response from cytokines that without decent blood supply to scar tissue you want to get rid of so you end up with long-term and continued muscle that and a lot of our surgery approaches and a lot of surgery where you just strip off the blood supply to the bone that it needs to help heal don't work very well because were not focused on how the body needs to really heal this fracture were focused on making x-ray and I did just make you look nice so your I think it's fascinating because essentially I've done the same I've done the same thing in my practice rub to move from traditional gastroenterology become almost a functional orthopedist yeah I would like to think that that I I just come to the table with some of the extra tools that I need to kinda set the table for the patient to help them heal I the body has unique ability to overcome a lot of things and in our body actually wants to heal a lot of times I'm just try to help people get our own way the same way the gastro neurology diet you're trying to help people get their own way from being about health right with with orthopedics I have to help the body the body knows the triggers and mechanisms and has the entire growth factors to help your body heal as we get a little older as we have chronic injury you rely radiation cigarettes coffee alcohol late nights cortisol stress we impair our body's ability to respond appropriately to injuries what the stem cell does for you is that the cell that helps you respond injury the problem is is you get a little older you have less of them and they don't do as much as a used I would guess that a second I'm still I want to hear the history only here got half because you ended with during residency restarted down do bone marrow concentrate bone marrow aspirate concentrate for nonunion fracture not only fractions your worst people so you guys were willing to try some things other people work well we had the opportunity because these people had no other options so the best part about doing a trauma fellowship is we were there last Hope we were the the Island of misfit toys so to speak Ryland Mr. Toyo we will use the we stood especially around Christmas time when that movie comes out with Chris Pringle we we would literally collect the injured patients from all over South Florida South North Florida Alabama Georgia we were the only level I trauma center on the West Coast of Florida and so when people would fail multiple surgeries we they walk into the resident clinic and you had to come up with a way to solve the problem and a lot of times it was as easy as finding a way to put more stress on the fracture you did have some plate that was plated and distraction so last times was just taken some screws out sometimes it was loosening up a frame that was holding the fracture apart and then let the fracture heal we would compress the frame so that the P0 electric effect fractures need stress to generate bone so stress across bone generates electronegative charge calcium and phosphorus are positively charged the biomechanics of basic physiology which unfortunately is certain's only when were supposed to forget that but apparently we do is trained out of us is what I was told the residence when the witnesses don't let don't let basic science and in physiology be trained out of you it into a surgical approach but when you create electronegative chars from a compression fracture calcium goes in and she get some healing without blood supply there is the rule in an osteopathic physician so it's a deal medical school because our team Dr. local state was the and and did manipulated felt good and I want to know how to do that I didn't even notice a difference on your will to be an orthopedic surgeon I said can I be an orthopedic surgeon because the he said absolutely yes that's about how I made that decision Okemos they had a deal medical school oh use was MD the last thing the world I wanted was a red diploma so state fans of loyalty I got a mistake know you was an easy decision I do know what the deal was but one of the owners of the time give me a book called the difference of genomics and you trying to teach me about the school just decided to go to and they said that when it comes to healing that the rule of the artery is supreme rule of the rings have the right to rule the artery is supreme but lymphatics have veto power I never heard this so that was the it's it's the foundation of a T still creation illustrate your stupid mess was created by the write a few stills and indeed he started the first year medical school in Kansas but he did it because he was unhappy with traditional medical approaches mobilization the joint instead of letting it get all swollen up seem to make the patient's function will be better and execute the plan by creating with: Patty pump people would read out all the way to push down her chest and he let it would create open up the alveoli to get people over dramatic pulmonary effusions by crating the sink on the lymphatic pump widget side of my chylomicrons on the lung tissue will with what we are doing it literally goes back to the foundations of what created a lot of modern medical sciences that without blood spiders and healing and that's true for orthopedic fractures is true for muscles tendon injuries we first started doing Bomer go back to that point on the trauma surgeon we were real sure that if we put bone marrow into a tendon that would make that was her fear with that we thought when we took Bomer Asper concentrate were real careful to make sure we we kept it in the in the osseous chart of the animals yet or you got it in the mentor factor was that there some really good studies published a bummer go back to the mid-90s there is a there was there was actually a really great study but here's a little they knew about what we're doing in Israel 1520 years ago there was a study on product complex possible tibial fractures which is a disaster if you have a tibial plateau the base you need if it's a complex fracture more than one particle shot six rights of Shatzer's fracture if you have a Shatzer six we used to call foobar that was our classification so we we with the Shatzer six what they did in Israel is they treated half of them with bone browser concentrate and half of them which is plating without moments were concentrated but interestingly because it was so early they added PRP to the bone restaurant concentrate thinking that it made work better and really all it does is dilute down so PRP the machine I have developed our tears I called them on sale define what you okay so the machine that we work with the machine I've been working with for for quite a while and have actually helped hopefully without taking real credit for anything but but knowing that that a been a significant part of innovation the development of their kit I'm actually patented the bone Ross Britt Catherine Catherine comes like it is my my design PRP is when you take whole blood and spin it down the machine to concentrate the growth factors get rid of some of the white cells and so you create was called platelet rich plasma write an platelet rich plasma is generated from the centrifugation of whole blood into the growth factors and platelets there needed to help get rid of inflammatory change a lot of times getting rid of the inflammatory change is the way to start the healing cycle inflammation gets in the way you put out the fire before you can grow new graphs right and so with inflammatory change if you turn the inflammation off ligaments tissue tendons heal faster with Bomer Esper concentrate what was it really understood as well in the 90s early 2000 and it is now hopefully is that bone marrow is still 97% whole blood so when we spend down bone marrow you're getting platelet rich plasma so your you are actually doing PRP yeah but you're doing PRP with stem cells yet so bone respite concentrate has the stem cells needed to help you heal and we know that those stem cells is when went on to hold your but while I was in school there wasn't such a thing as a musical social musical stem cell was named the music will stem cell 1995 by Dr. Arnie Case Western and Arnie Kaplan named a cell that previously in medicine what we do is we name cells based on the characteristics right so before it was musical stem cell was in a plastic undifferentiated employee potential adherent so that I liked it way better back in that day. I call it Mrs. a couple of them so well and and I doubt that there's terms equals some so most commonly know what they're talking about right so there's a CD marker a surface cell marker verse 600 different types of the cells based on their surface marker so we talked about was equal stem cells people think there's like one time no there someone that we don't really need help you heal the sum of the week need crucially to help you heal and we know the difference between these based on their CD markers we've actually quantitated what cells we want was told we don't want found a way to concentrate the cells want we do the spends so with bone marrow you're getting platelet rich plasma but you're getting the best platelet rich plasma because you're spending it from the most immature blood when you spend on whole blood you're getting PRP we are getting them no stem cells alright so let's clarify because it's a definition is really that what you're saying is that saying just stem cells doesn't mean just themselves how stem cells we have these mesenchymal stem cells which is the earliest of the stencil correct you guys have markers where you can determine the type of one that you know which ones do you need what was preferentially help you grow Cartledge what was professorship tendon what was preferentially grow fat right so fat stem cells that if you make if you make fat graph or stem so graph from fat those cells grow fat really well yeah we know what they don't grow really well's cartilage because there's a peptide called Sox nine this are secreted by the frustum so so when we quantitate stem cells I'm not interested in what those cells could become a me to say right now is this my pet. If you get a stem cell lecture in the first slide they show is this one so become these five types of cells in the differentiation and the building of the cells become these five is what makes somatic that's completely wrong that's true in the lab that's not how it works in the body what happens in the body is your set your body season injury it secretes cells starting with the humor putting stem cell which is the CD34 right so thrive for all the one second I got a good message where it says I can get a little stressed out I feel like I'm producing the wrong stem cells because I putting on weight change my stem cells to get rid of the adipose tissue and so sent there just go I got lost that CD something or other yeah you are way more so than I thought I would be as a orthopedist at the document bone bent may make straight actually know the medical school the running joke at time UNIX was the hardest residency to get into W had to become stupid right away take the smartest guys we need only to talk about when I mean I mean it when I say don't unlearn medicine right you the orthopedic resident was the hardest residency get to but you are expected to never even look at an EKG again if you walked into the surgery patient and you're like looking at their head or their EKG the attendings walking to go one the how you do know that you talk about this is Eric little people to sleep we have a certain dog like no dying right thing will similarly used to put my patients asleep so you feel like Dr. McKenna the CD six and 07 mesenchymal cells ready there's a joke that was that he found an orthopedist and the radiologist near going opposite direction of the code blue running away from the seed that what we used to say you know if you want if you have a dollar and you want to hide from a surgeon or from any kind of position there different places you put it right 100 from radiologist to tape to patient if you want to hide it if you want to hide it from orthopedic surgeon you put it in a book if you want to hide up a plastic surgeon we can hundred dollars from plastics are you going at a rabbit hole there went out on CD34 what were your talk was initiation healing right so with the CD34 it secretes a peptide for PG to PGE2 is is one of those keys and starting new vessel growth will the way to grow hair the way to have ED go away way to have stress urinary incontinence go away the way to have your wrinkles go away the way to have your fracture healed way to have your tendon remote you had me at wrinkles ED hair okay so so now we start out treating nonunion fractures right what we figure out pretty quick that if you put Bomer Asper concentrate it was it wasn't and is a great study published it was a limb salvage patient in Japan where 15 surgeries big proximal defect it's possible to be a and the the general surgeon was was livid at the orthopedic surgeons want to to put bone restaurant concentrate a fracture because he was proving that there was no vascularity to the way so to back door the orthopedic surgeon the supposed case report that a vascular surgeon does this arteriogram a lower extremity and it shows that there's literally no collateral flow around the fracture site is kid basically has a limb salvage frame on his leg this big proximal defect two years out multiple fascia economies nonmusical leg mask were really high needs needs annotation orthopedic surgeon is busy all the stuff about Mercer concentrate wants to inject bone marrow before he takes frame off eventually as a surgeon you become kind of emotionally connected to to your work right the guy does not want to cut the slide off the vascular surgeon try to prove needs come off he does arteriogram family Stone will it cut off so they have bone marrow injected in the fracture site at eight weeks they redo the arteriogram because the orthopedic surgeon the arterial was ordered by him but you start to see new bone kids have less pain from weight on lag you get new bone formation but they have this arteriogram set out to the shows no blood flow so they redo the arteriogram and there's all this collateral circulation on the fracture site so basically forever listening arteriogram is a study were it actually shows the arteries they put Diana vessel and shows up on x-ray and there is no blood flow going below over the fracture risers no.the die stops and there's a little bitty pattern this will trickle that I injected something into the bone not into the are not in the artery into the Perry steel sleeve the covering of the bone with the with the board there was no bone produces big bony defect there but Bomer us for concentrating their the way the bone roster concentrate work it didn't become bone which is what we thought what it does is it secretes the peptides and proteins necessary to bring new blood flow which allowed the bone to heal now there's a certain paragraphs that out there shows no collateral flow say that saying again that blood flow the rule of the artery is supreme the arteries and she still give him credit for that from the 1800s rule the arteries supreme lymphatics have veto power and that's a Dr. Graham from local states manipulation class, add on that if everything so swollen of blood flow can't get to it okay yeah so you guys injected this is the first time you saw that Ballmer answer because this can be a great segue will be go to the next half hour more we really do jump into the stem cell we got a little will try and keep it as it at a level that we can help people because I get a lot of back to let me make sure I'm being asked questions like it doesn't help with back yes to the health of the components were next on but on the great papers published read everyone says oh there's no literature published there's been 3500 papers published with my little Catherine the kit was designed for bummer aspirate 3500 papers published there's never been in toward report there's never been a tumor there's never been you can't reject your own bone marrow so this is the bone marrow aspirate injections you guys are doing this is the very beginning of Stansberry Reese is the only sell the US are allowed to cost himself you cannot you guys really literally were the first people playing around stems the trauma surgeon department: bone marrow yet not not knowing what we were doing we are using Bomer Asper concentrate for the fatty component of marrow that seem to help fracture so faster which is where microfracture surgery the knee all this comes in my mind from we would we do niece go there's an uncovered Carla Jerry would put a couple holes in the bone where in the bone the lesson bone marrow leak into the knee thinking that I hope the cards losing hills, microfracture doesn't work very well it creates a cartilaginous Good Cartilage but It Does Heal Something But My Thought Was When I Credit This Catheter If a Couple Drops of Bone Marrow Makes a Difference What Would What Would 60 ML Concentrated on the 45 That Was Where We Started with This During Joliet Harlan's Injuries at Work That's Where That Slow Beginning That's That's Only for Mia Do You Think I Do Think That Today's Bone Marrow in the Stem Cells Come from Bone Marrow Are Really Adapt to This Type of Healing to the Because That's Where We Release Our Red Blood Cells for Your Body Does Yeah Okay so This Is How Your Body Is Ready Right Right That You Were Not Were Inventing a New Way to Make Something He'll This Is How the Body Heals This Is Where Those You Know It This How God Does It Right He Sends the Cell There Is Secretes As Protein Vessel Grows You Get Your Butts by Tenant's Right This Is How It Works Already Is Just As We Get Older Or If You Get Your Lymphedema Swelling Only for the Lymphatic Flow Attacker Has Veto Power Is a Big Swollen Leg Give a Big Swollen Foot Good Books I Can't Get to It Right so It's All about Mobilizing Ankle Fracture and Also so That Blood Flow Can Get to It Because Official Swollen You Can't Put Any Extra Water in a Full Glass So New Water Can't Get to It That All Contaminated Dead Water Sits There yet to Pour the Glass out a Little Bit to Put Some New Healthy Water Back in That's How Bloodflow Work Which Is Why the Lymphedema and Lymphedema Is so Dangerous and Has It Has Absolute Control over Blood Flow to the to the Injured Tissue before We Dive Deep into Stem Cells Does PRP Work I Love You so Here's the Deal so Peer Peas like Boomer Light Okay so PRP Is Bone Marrow Announced Himself It's It's a Good Growth Component It's Great at It's a One-Time Shot Right so You When You Pop European Something You Get a One-Time Shot Growth Factors That Limits and Stops the Inflammatory Response from Cytokines You Undergo Tissue There's No Stem Cells You're Not Getting a Stem Cell Injection Which Is One of the Things He Pushes Me over the Edges Somewhere with I Went Got Stem Cells from My Blood Union You Got an Injection Visitor Was a Stem so That PRP Player Was Positive Now PRP Is Also a Bummer With Our Stem Cells in Bone Marrow so When You Say PRP Splenda If You Got It from Your Whole Blood It's Just Pure. If You Got Boom Roster Concentrate It's All the Best Components of European Stencils about That That Study Is Telling about So Here's How the Little so Even Though the They Publish Is Great Study Showing the Bonus Request Rate Help the Complex Factors Heal 50% Faster and All of Them Healed The Ones That Didn't Have Bone Marrow Not All of Them Healed and They Took Twice As Long Hill That Was Published 20 Years Ago Right with Bomer Asper Concentrate but Would They Knew so Little about Bomer Also Concentrate That They Spun down Whole Blood to In the Same Machine to Try to Give It More Volume Because We Thought the PRP Might Help the Bummer Work Better When in Actuality You're Already Getting PRP When You Spend Them Boomers of All We Were Doing Were Literally in a Study in Israel What They Were Just Alluding It's Just Laughing This Is Similar When You Say No You Think It's Them so You Got Blood You Are Talking about Fasting And I Had Some Friends and Maybe Overdone It on Adderall Little Bit like Three Days without Eating and Not Basing Radiology Headsets of Money I Was in Jail All Weekend and You Know There's a Great View We Talked about Intermittent Fasting There's a Great Study Published in Cell Metabolism Last Year That Showed That the That Are Correlated to Longevity in Mice And the the Mice Had the Longest Food Free Intervals Actually Increase Life Plaintiff Please Got a Hold of Our Dr. Wayne McKenna I Will Lose Track down the Same 10,000 This Is the Only 24 Hour Take Anywhere Platforms Dedicated to Food and Fun Clear Spoony Our Townhall.com, Where the Mother Report about to Be Released Atty. Gen. Bars As a Special Counsel's Russia Probe Leaves No Doubt That Moscow Did Try to Interfere in the 2016 US Electric Thanks to the Special Counsel's Thorough Investigation We Now Know That the Russian Operatives Who Perpetrated These Schemes Did Not Have the Cooperation of Pres. Trump or the Trunk Campaign or the Knowing Assistance of Any Other American for That Matter Bars As White House Cooperated Fully with the Special Counsel's Investigators And He Says the Evidence Gathered by Those Investigators Not Sufficient to Establish Obstruction of Justice White House Officials Had to Go over Each and Every Page of the 400 Page Molar Report the Trump White House Is Already Pronounced Total Exoneration for the President in the Russia Collusion Case but Attorneys and White House Staff Members Will Be Pouring over the Molar Documents Findings so They Can Craft an Official White House Response the President's Legal Team Also Is Planning to Release a Rebuttal of the Molar Report That's White House Correspondent Greg Clarkson Boeing Says It's Making Good Progress in a Software Fix for a Troubled Mac Series of 737s Following Highlights Engineers Technical Experts and Our Partners Were Comprehensively Testing the Software Make Sure That It Does the Job And They're Taking the Time To Get It Right Boeing CEO Dennis Wallenberg Max Gets Taken Out Of Service Just about Everywhere Pending the Software Update A Booming Job Market Means a Number of Americans Filing for Unemployment Now Dropped to the Lowest Level since November 1969 Retail Sales Surge Last Month up 1.6% On Wall Street Dow 53 Points Higher the S&P Is Two Points Lower the NASDAQ down 25 More of These Stories Said Townhall.com Now You Can Fly Anywhere in the World and Paid Discount Prices on Your Airline Tickets Flight to Date Alignment Harassment to Read or Anywhere Else You Want to Go and Pay A Lot Less Guarantee Quality International Travel Department Right Now Low-Cost Airlines 800 452 1075 800-452-1075 That's 800-452-1075 Got an Old Car You Can Donate It Whether It's Running or Not to the United Breast Cancer Foundation and Save the Life They'll Even Come and Pick It up for Free The United Breast Cancer Foundation Has Saved Hundreds of Women's Lives through Their Free or Low-Cost Breast Screening Exams but Now They Need Your Help The United Breast Cancer Foundation Wants to Save More Lives through Early Detection by Offering Women Free or Low-Cost Breast Screening Exams In Donating Your Old Car SUV or Truck Whether It's Running or Not Helps Pay for Them Plus You Get a Charitable Tax Deduction Help the United Breast Cancer Foundation Save Lives by Donating Your Old Car SUV or Truck Call Now for Free Pickup 800-245-0823 800-245-0823 800-245-0823 All Right Now That Number Again Is 800-245-0823 Never Forgotten Apparel Is More Than Just a Premium Women's and Men's Clothing Line It's a Movement to Remind Us to Wear American-Made and Serve Those Who Serve Us Our Heroes Never Forgotten Apparel Gives 20% of Their Total Sales to Nonprofits That Support Homeless Veterans and Off-Duty Firefighters and 50% to Individual Veterans and Firefighters in Need Nationwide Checkout Never Forgotten Apparel.com Use Promo Code Matt and ATT And Get 15% off Your Purchase Welcome Back It Is Now the Second Hour at Episode Number Seven I Got Kicked Back to Chimeric Rigor Jointly with Your Host Brown and We Also Have a Studio Today Dr. Wade McKenna Stem Cell Expert and Longtime Orthopedic Surgeon Well Everything We Start Firing up A Lot Of Brain Energy Going on on That Last Time I Started Hot and I'm Wearing My Tequila 512 Shirts Nicely Believe the Two People Sit in Front of Me Happened to Be Some Ownership in It and Big Fans of the Product and Enjoy Some Tequila Moms Will Have Some Tequila If I Want to Yes All Modifier Question but I Will Still Signal CBD Here to Regenerate My Ananda Mind into E.G. Nice Because I Think I Spent Some There with the Trying to Keep up with Dr. McKenna I Went through to Believe That I Write the Name That It It It but It Was Some System Select for I Was Looking See Who's behind Me but It But Literally We Been over 10,000 Cases in US Now so so Let Me Let Me Throw One out for You We Got a Message from Victoria That Says Can You Fix Bone on Bone Degenerative Discs so Here's the Short Answer in the You Know Me Enough Already by Now You Notice the In a Good Prospective Randomized Study of This Started with Just Pure P Because Again Bo Mastro Concentrate the Only Reason PRP Exists Is a Product Is Because We Couldn't Get Approval for Bone Marrow so We Were Spinning down Horseplay on the Equine Market You Could Sell PRP into People Pay More to Have Their Horse Injected My World Are Kid and That Horse Has Four Extremities and so Were Spinning on Whole Blood Created PRP While We're Waiting on the FDA to Approve Bone Marrow Whole Blood Is Exempt In Bone Marrow Was an and so Did Get the Validations on Bone Marrow and A Lot Of Pure P Was Created so There You Go so the Short Answer Is Enter Disco Injections Hemorrhoids Are Several Great Papers Are Republished and the Most Recent One at Two Years 92% of the Patients Had Inner Disco Injections on Degenerative Disc Disease And and I Would I Would Take It Even Step Farther and That in Our in Our Clinical Practice with over 300 Discs Now In That If You Have an Annular Tear Bring a Tear in the Covering of the Desk That Is a Primary Pain Generator It's a Bright Spot on the MRI Called Heisey Lesion Are High in Tinsel Science Is a Signal A Lot Of Radiologist Don't Now Failed to Mention That I Guess but If There's an Annular Tear High Intensity Signal within That within the Disc That Alone Is a Dramatic Pain Generator It Can Even Cause This Exact Same Symptoms As a Herniated Disc Would As Far As Lower Extremity Pain and Weakness Because the Nerve Crosses the Annular Tear in Your Tear Generate Substance P Generates the Cytokines Generates Exact Same Pain Response so Those Two Times of Radicular Pain Coming from the Back Leg and Hip Pain Radicular so That's the Old Folks Called Sciatica If It Can Be Pressure Because My Big Herniated Disc Neural Foraminal Stenosis Meeting the Canal Gets to Tie the Facets Your Baguette Hypertrophic Get Extra-Large They Were out so There's There's You Can Have Pressure Stenotic Pressure on Her Nerve Were Still Think It's Just Been Crushed That Causes Leg and Hip Pain and Back Pain Or You Can Have a Chemical Radiculopathy Created by a Tear in the Desk and It Feels the Same Patient until Difference One of Almost Everybody Else Is My Bulging Disc yet I Could Be There but but but Bulging to Start the Problem Because Here's What We Know Here's What's Already Published If Either MRIs and A Lot Of People Have No Back and Leg Pain A Lot Of Them Have Bulging This So How's It Happen How How Can Some People Smoking Just Hurts a Bit Was Bulging the Stone Right Now Is That If You Experience If You Have a Bulging Disc the Nonoperative Follow-Up At Two Years Is the Same As Opera Follow If You Don't Have Weakness If You Have Pain That You Can Tolerate and You Have Weakness in the Lower Extremity at Two Years Your Doom the Same As a People How Discectomy If You Don't Have Surgery What That's Published For Long Time so Were Not so If You Intrude a Free Fragment That Free Fragment Will Absorb Your Body Is Really Adept at Getting Rid of Items Extruded into the Canal and It Will Actually Absorb and and Get Rid of a Free Fragment As Long As Every Fragment Is Important so Much Pressure on the Nerve That It Decreases the Blood Supply from the Pressure Causes Weakness in the Lower Extremity from the Pressure the Nurse Stops Working You Have Leg Pain Your Little Foot Drop below Witnessing That Surgery You Have Weakness and You Start Paying What's Publish Now Is If We Inject That Disk the Annular Tear That Doesn't Go Away on Its Own Will Heal And Most of the Time 92% in a Study If the Annular Tear Heals The Back and Leg Pain Go Away 92 Persons 92% of the Playhouse That Had an Injection Didn't Go on to a Primary Fusion While Now Now Here's the Other Side of The Patients Had a Fusion at Five Years 30% of Them Had Two Surgeries So If You Have Fusion at One Level 30% Time of the Next Five Years Your Risk of Having a Second Surgery Either Refused at the Level above or below or Hardware Removal or Revision or You Get Extra Bone from the Fusion at the Re-Open up the Nerve Roots Have To Do in Reframing Autonomy Every Time You Do Surgery The Muscles of the Back Diablo So the Paravertebral Muscles the Muscle Mass so It Would When You Look at Some of Been for You It Will Look like Dinosaur Right That Little Thing the Bridge the Sticks up Familiar Back Check Is Called the Spinous Process The Muscles That Lay on Each Side of the Spinous Process Have To Be Moved Out Of the Way For You to Do a Back Surgery Weeks Make Fun of Spine Surgeons When I Was a Fellow in Trauma Because They Don't Have One Incision Is Midline Low Back Tonight We Had Learn All These Other Incisions and Sponsors in Certain Were More Online But What They Don't Learn That Trauma Surgeons Learn As We Make an Incision The Is Designed to Not Limit the Structure Function Blood Spire Nerve to the Muscle Were Moving In the Spine The Multiply the Small Muscle Each Side of That Bridge The Nerve and Vessel Come from Midland in the Back but Were Moving Away Is It When You Do an MRI of Someone's Back Is Set Back Surgery Initially The Muscles on Each Side of That Look like Filet Mignon That's Tenderloin Right That's the Backstrap Vassar Hunters Were Not Talking Tenderly Farewell Real Hungry so When You Move That Muscle out a Way And You Go Back and You Do an MRI That Back That Had Surgery and Other Fibers out And Having Pain Again And the Neurosurgeon Looks at the Films Goes While the Disc Looks Great the Nerve Roots Wide Open Usual Payments and That There Is No Reason for Your Backs on Well If You Look at the MRI Used To Look like Tenderloin Now Looks like Prime Bootleg like Strip Steak or or or Worse Just We Call White Muscle Syndrome Is Just Whole Thing Just Looks like Fatting a Filtration like Arby's Like Times like More like Crime-Ridden Right Is a Little Bit of Muscle Aches and Their Diagnosis Are You You Are Fasting for What You Are Armies Roy Rogers for My Generation Has To Follow-Up Question That She Was Asking How Many Injections Did That Take to Achieve the Most of Time Is One One Engine One Treatment One Injection We Do What We What We Do Is We Will You Be More Specific Rest of My My Problems Stem Cell Science As a Whole Is A Lot Of Times Patients Get in the Mix Were There Never Really Diagnosed and I Am a Firm Believer That You Can't Treat Something If You Didn't Diagnose It If I Don't Know What I'm Treating My Chances of Making It Go Away Are Pretty Slim and Entered and Unfortunately A Lot Of Stem Cell Injectors out There Don't Make the Effort to Actually Diagnose a Problem but to Get There Won't Inject Anything Well That's That That's Very Nonspecific Treatment in It, It Kinda Puts Your Your Results Risk If You Don't Know What You're Treating Because You Know What You Can Heal What You Can't Heal When You Do What We so What We Do We Were Doing Disc Injections I Want to Know That Was the Painter So There's an Old Test That Used To Be the Standard of Care before You Had a Fusion Now Because Fusions Are so Rampant in Our Country We've Gotten Away from More Specific Diagnosis on Making Sure T

1. Socialism runs in the face of human nature. 2. Video of children out of control at east hs during strike. 3. Teacher's Strike discussion continued. 4. Guest: Gretchen with DDN for V-Day.

DDN's Marc Pendleton Talks Week 10 HS FB On Kinner And Schlemmer

I finally started to record new episodes again!!! In this episode: - The reasons behind this reboot; - My comment on Tintri assets being acquired by DDN; - My latest article about Object Storage on LinkedIn: https://www.linkedin.com/pulse/understand-drive-object-storage-adoption-enterprise-enrico-signoretti/ Stay tuned for new episodes!

Ross Bjella, MBA is the founder and CEO of Alithias, a patient advocacy and population health analytics company serving self-insured employers, insurance companies, networks, and third party administrators.  “Alithias” means “the truth” in Greek and currently has >60,000 lives with access to the platform.  Ross has held senior management positions in the health care industry, including pharmaceuticals, biotech, and medical devices. Prior to Alithias, Ross served as the CEO of DDN, a leading business process outsourcer for pharma and biotech companies. Ross still consults with pharma companies about 3PL selection and resolving and supply chain issues from time to time.  He has a degree in Biology from the University of Minnesota and a MBA from the University of Southern California. 00:00 The attributes of a winning model. 02:30 Attributes of a failing model. 03:45 Lack of transparency about costs. 05:00 How high deductible plans increase the likelihood that patients will refuse necessary care. 06:50 What employers are able to control and how they can help solve these problems. 08:50 The disappearance of wellness trends. 11:00 Have we reached an inflection point? 13:30 The leading edge of employers. 14:00 The challenges of being a smaller employer vs a large employer and getting health systems to listen to their needs. 15:25 Consumer-driven health care. 15:40 How Alithias can help change health care trends for employers. 21:00 The higher the quality, the higher the cost? 22:15 Providers with fixed-bundled prices. 23:40 How employees know where they should go for procedures. 27:00 Understanding cost structure. 31:00 You can learn more at alithias.com or by emailing Ross at ross@alithias.com, or following Ross on twitter @rossbjella.

In this RichReport slidecast, James Coomer from DDN presents: Infinite Memory Engine: HPC in the FLASH Era. "DDN’s Infinite Memory Engine (IME) is a scale-out, flash-native, software-defined, storage cache that streamlines the data path for application IO. IME interfaces directly to applications and secures IO via a data path that eliminates file system bottlenecks. With IME, architects can realize true flash-cache economics with a storage architecture that separates capacity from performance." James Coomer’s career has been spent entirely in High Performance Computing. James began with a PhD in Theoretical Physics working on the fastest machines in Europe performing large scale atomic simulations. Subsequently James has occupied the breadth of technical roles in HPC including back line support, installation, consultancy, training, and latterly pre-sales and design in organisations including Sun Microsystems, Streamline Computing and Dell. James enjoys daily direct contact with customers across all sectors in HPC and presents widely on HPC topics. Download the MP3 * Subscribe on iTunes * Subscribe to RSS  Sign up for our insideHPC Newsletter

oIn our 27th episode we talk with Molly Rector (@MollyRector), CMO & EVP of Product Management/Worldwide Marketing for DDN.  Howard and I have known Molly since her days at Spectra Logic. Molly is also on the BoD of SNIA and Active Archive Alliance (AAA), so she's very active in the storage industry, on multiple dimensions and a very … Continue reading "GreyBeards talk HPC storage with Molly Rector, CMO & EVP, DDN"

In this episode of This Week in HPC, Michael Feldman and Addison Snell from Intersect360 Research discuss the next generation Cray XC40 supercomputer with DataWarp technology as well the introduction of a new Scale-out Storage Appliance from DDN based on GPFS. The post This Week in HPC: Cray Unveils Next Generation Supercomputer and DDN Extends Product Line with Scale-out Appliance appeared first on High-Performance Computing News Analysis | insideHPC.

Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function. Quite a few of these genes show a specific or preferential mRNA expression in the renal glomerulus. To identify additional candidate genes involved in glomerular function in humans we generated a human renal glomerulus-enriched gene expression dataset (REGGED) by comparing gene expression profiles from human glomeruli and tubulointerstitium obtained from six transplant living donors using Affymetrix HG-U133A arrays. This analysis resulted in 677 genes with prominent overrepresentation in the glomerulus. Genes with 'a priori' known prominent glomerular expression served for validation and were all found in the novel dataset (e.g. CDKN1, DAG1, DDN, EHD3, MYH9, NES, NPHS1, NPHS2, PDPN, PLA2R1, PLCE1, PODXL, PTPRO, SYNPO, TCF21, TJP1, WT1). The mRNA expression of several novel glomerulus-enriched genes in REGGED was validated by qRT-PCR. Gene ontology and pathway analysis identified biological processes previously not reported to be of relevance in glomeruli of healthy human adult kidneys including among others axon guidance. This finding was further validated by assessing the expression of the axon guidance molecules neuritin (NRN1) and roundabout receptor ROBO1 and -2. In diabetic nephropathy, a prevalent glomerulopathy, differential regulation of glomerular ROBO2 mRNA was found.In summary, novel transcripts with predominant expression in the human glomerulus could be identified using a comparative strategy on microdissected nephrons. A systematic analysis of this glomerulus-specific gene expression dataset allows the detection of target molecules and biological processes involved in glomerular biology and renal disease.