Podcasts about cys

Send us a textHere are some effective ways to reduce the CYS level in your swimming pool. There are many methods but one is tried and true. Support the Pool Guy Podcast Show Sponsors! HASA delivers clean, healthy water solutions. https://bit.ly/HASAhttps://www.orendatech.com/The Bottom Feeder Professional Battery Powered Vacuum Systemhttps://bit.ly/THEBOTTOMFEEDERAnd Skimmer, America's #1 pool service software! Try Skimmer FREE at getskimmer.com/poolguy.Thanks for listening and I hope you find the Podcast helpful! For other free resources to further help you:Visit my Website: https://www.swimmingpoollearning.comWatch on YouTube: https://www.youtube.com/@SPLPodcast Site: https://the-pool-guy-podcast-show.onpodium.com/

Send us a textIn this episode of From The Inside Out with Rivkah and Eda, we tackle the paradoxes and puzzles that we come up against in Torah and Judaism with Rabbi Dov Schochet. Right in time for Rosh Hashana, this episode will help you enter the new year with clarity, drive, and purpose. We cover questions such as: -What are the Torah's guidelines on seeking and granting forgiveness?-What is the Torah's view on healing and finding joy?- What does Teshuva mean practically for us today?- What is the Torah's view on balancing materialism and spirituality, especially when asking for blessings on Rosh Hashanah?- How should one navigate the political landscape as a Torah-observant Jew?- Can the Torah laws adapt to modern developments?- How do you reconcile the idea that "the world was created for me" with humility?-What guidance does the Torah give on deciding between staying in yeshiva and entering the workforce?- What is healthy love according to the Torah, and how does it differ from selfish or destructive love?And many more!We hope you enjoy this episode and wish you a sweet year full of revealed goodness andmiracles!As always, thank you for being our treasured listeners and supporters.xo,Rivkah & edaFEEDBACK:We'd love to hear your thoughts on making From The Inside Out Podcast even better and more tailored for you! Please take our survey here: https://vc7ah0gv.forms.app/ftio GUEST BIO:Rabbi Dov Schochet is a respected scholar and educator at The Shul of Bal Harbour. He teaches a broad range of subjects, including Textual Studies, Jewish Law, Jewish Literature, Jewish Ethics, and Jewish Philosophy. With a deep commitment to Jewish education, Rabbi Schochet has become an influential figure in the Jewish community of Miami. Known for his approachability, he is frequently sought after for guidance, answering questions on complex Torah issues, personal challenges, and Jewish practices. He provides clear, thoughtful responses, helping individuals navigate their spiritual journeys and deepen their understanding of Jewish teachings. His approachable demeanor and wisdom have earned him a reputation as a trusted advisor within his community, where he serves on the faculty, advisory board, and curriculum chair at CYS college.EPISODE SPONSOREven with the best intentions, it's easy to forget or miss a day of giving charity. Imagine the opportunity to partner daily with the Lubavitcher Rebbe in giving Tzedaka.71 years ago, the Rebbe launched Keren Hashana, a fund ensuring that no day goes by without giving charity. By donating an amount reflecting the 355 days of this year, Keren Hashana disburses charity twice daily—before Shachris and Mincha—guaranteeing your daily giving.The amount doesn't matter; the key is consistency- to give Tzedaka every year. Funds support those in need through Chabad's global network, from single-parent households to educational subsidies and emergency assistance. Join thousands worldwide and be a giver every day.Become a part of this project and Donate at MyKerenHashana.com

BUFFALO, NY- August 27, 2024 – A new #research perspective was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15 on July 25, 2024, entitled, “Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms.” Oxidative stress (OS) - characterized by an imbalance between oxidants and antioxidants - leads to the formation of oxidative posttranslational modifications (PTMs), including those involving cysteine (Cys) residues in aging proteomes. Specifically, the formation of trioxidized Cys (t-Cys) results in permanent protein damage. Recent findings in rodents have revealed that irregular regulation of t-Cys residues in the aging proteome disrupts homeostatic phosphorylation signaling, leading to alterations in proteins similar to those caused by phosphorylated serine (p-Ser) residues. In this perspective, researchers José Antonio Sánchez Milán, María Mulet, Aida Serra and Xavier Gallart-Palau from University Hospital Arnau de Vilanova (HUAV) and University of Lleida (UdL), present novel data, validating the increase of specific t-Cys sites associated with aging in a blood-related circulating human proteome. "The scope and findings included here support the hypothesis that t-Cys residues may serve as important mechanistic and biological markers, warranting further exploration in the context of unhealthy aging and age-related major diseases.” DOI - https://doi.org/10.18632/aging.206036 Corresponding authors - Aida Serra - aida.serra@udl.cat, and Xavier Gallart-Palau - xgallart@irblleida.cat Video short - https://www.youtube.com/watch?v=roO_8WMGak8 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206036 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, oxidative stress, unhealthy aging, t-Cys, aging diseases, aging proteome About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

As the summer season kicks into high gear, the Fort Cavazos Child and Youth Services program is working hard to provide events and activities that educate, engage and entertain youngsters while they are out of school. Listen as the crew of the Great Big Podcast sits down with Kristine Caparco, CYS school liaison officer, to learn all about how CYS supports youth during the summer and year-round.SUBMIT: FortCavazosPAO@gmail.comFACEBOOK: fortcavazosarmy   INSTAGRAM: @fortcavazosarmyTWITTER: @fortcavazosarmy   All music obtained, royalty-free, through Filter by Songtradr: "Gun Metal Grey" - Delicious Allstars; "Learning By Doing" - Niklas Olovso.This podcast is a production of U.S. Army Garrison Fort Cavazos and Fort Cavazos Public Affairs.

Charges have been dropped against three CYS workers accused of contributing to the death of an infant. Gambling in Pennsylvania keeps growing and growing. A long-awaited tiny homes village for homeless veterans will open soon. And you can check out the site of a Revolutionary POW camp soon.

In the conclusion of his CYS series, Pastor Brian takes us deeper into the idea of choosing our suffering. Will we take the path of growth and resilience over passive endurance? We are introduced to a talented young artist, Jacob… Read More CYS // Choose Your Suffering Part II The post CYS // Choose Your Suffering Part II appeared first on Refuge.Church.

Researchers observe what ubiquitination hinges on Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Hiroki Konno and Holger Flechsig at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University.The research described in this podcast was published in Nano Letters in December 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers observe what ubiquitination hinges onResearchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.Ubiquitination – the addition of the protein ubiquitin – is a key stage in many cell processes, such as protein degradation, DNA repairs, and signal transduction. Using high-speed atomic force microscopy (AFM) and molecular modelling, researchers led by Hiroki Konno and Holger Flechsig at WPI-NanoLSI, Kanazawa University have identified how the mobility of a ubiquitination related enzyme hinge allows ubiquitination to take place.So what was known already about ubiquitination?Previous studies have identified a number of enzymes that facilitate ubiquitination, including an enzyme that activates ubiquitin (E1), an enzyme that conjugates it (E2), and an enzyme that catalyzes ubiquitin protein joining (that is, a ligase, E3) to a target protein. The HECT-type E3 ligase is characterized by a HECT domain that comprises an N lobe with the E2-binding site and a C lobe with a catalytic Cys residue, A flexible hinge connects the two lobes, leading to the hypothesis that ubiquitination is facilitated by the rearrangement of the protein around this hinge. Konno and their collaborators deployed their high-speed atomic force microscope to hunt for evidence that this was the case.So what did they find out?The researchers noted that when the HECT domain was crystallized with a type of E2 enzyme, it formed an L shape such that the distance between the catalytic Cys residue of the HECT domain and the catalytic Cys of the E2 enzyme was 41 Å – too far for the transfer of ubiquitin. However, in its catalytic conformation the HECT domain has a different shape where the distance between the two catalytic Cys residues is much closer – just 8 Å – so this is thought to be a “catalytic conformation”.Analysis of high-speed-AFM images of a wild-type HECT domain of E6AP revealed two conformations – one of which looked spherical and the other oval. Using AFM simulations they attributed the oval shapes to the L conformation and spherical shapes are either the catalytic conformation or the so called inverted T conformation, which had been observed in the another type of HECT domain where the distance between the Cys residues is 16 Å. To overcome the spatio-temporal resolution limitations of imaging, the experiments were complemented by molecular modelling to visualize HECT domain conformational motions at the atomistic level. Simulation AFM was used to generate a corresponding pseudo AFM movie, which clearly showed the change from spherical to the oval shaped topography.“Although experimental limitations do not allow us to resolve the intermediate conformations,” explain the researchers in their report of the work. “The performed modeling provides evidence that the transitions between spherical and oval HECT domain shapes observed under high-speed-AFM correspond to functional conformational motions under which the C-lobe rotates relative to the N-lobe, thereby allowing the change between catalytic and L-shape HECT conformations.”Further experiments with mutant HECT domains with less flexibility in the hNanoLSI Podcast website

10 Tips to get the most out of your investment in BNIAre you looking to maximize the potential of your BNI membership? Join us on this exclusive podcast series hosted by none other than BNI Executive Director, Cys Bronner. With decades of experience in building successful networking communities, Cys shares invaluable insights and strategies to supercharge your BNI journey. In this episode, Cys dives deep into the core principles of effective networking within your BNI chapter, unveiling 10 actionable tips designed to elevate your experience and drive tangible results. Whether you're a seasoned BNI member or just starting out, these tips are guaranteed to transform your networking game.BNI4Success Podcasts The Voice of BNI Greater Los Angeles; Where we'll talk about referral networking that works!http://bnipodcast4success.com

On this episode of Fort Meade Declassified, we sit down with parents of students in the Anne Arundel County Public Schools' Meade Cluster, Rita Wharton and Keyontay Lashley as well as Fort Meade's Child Youth Services School Liaison Officer, Meredith McCandless, to discuss Meade Cluster schools, redistricting and resources available to Meade Cluster students as members of the Fort Meade community.

In this profoundly moving episode, we're honored to have Jessica Hubbard, the CEO of Casa Youth Shelter, share her inspiring journey of hope. Sit back and get ready to be inspired as Jessica opens up about her experiences, the impact of counseling on youth in crisis, and the legacy of hope she's building. Her story is a testament to the power of resilience and the difference one person can make in the lives of many. Through her work and dedication, Jessica continues to inspire and uplift us all, proving that every challenge can lead to a brighter future. Connect with us to hear more stories of real people making real differences. Stream this episode now and let Jessica Hubbard's journey inspire you to find hope in your own path. Enjoy! #Upbringing #LicensedClinicalTeam #SexTraffickingSurvivorStories #Experience #PromotingKindnessAndHope CHAPTERS: 0:22 - Introduction 1:10 - Counseling Importance 4:31 - Passion in Counseling 6:02 - Past Experiences and Passion 11:08 - Identifying Abuse Signs 11:53 - Recognizing Abuse in Children 19:08 - Essential Needs of Children 21:00 - Personal Turning Point 24:06 - Parental Lessons for Children 27:03 - Lulu's Story 30:53 - Legacy Aspirations 31:14 - Guidance for Teens 33:24 - Program Enrollment Process 37:55 - Facility Overview and Location 41:47 - Supporting the Cause 45:54 - Art with Heart Gala Event 48:00 - Program Success Stories 54:44 - Law Degree Benefits in Non-Profit 1:00:00 - Leadership Qualities 1:02:26 - Everyday Heroes Segment 1:05:00 - Implementing Life Lessons 1:07:40 - Building Deep Connections 1:10:18 - Lesson Implementation Insights 1:10:30 - Heartfelt Conclusion You can reach Jessica at jhubbard@casayouthshelter.org, and learn more about CYS at ⁠https://casayouthshelter.org/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/fromthehart/message

A Wendy Williams Special News Report: Exploring The Role of Family in Human & Social Welfare Versus Wells Fargo's decision to appoint an independent family member with the court's blessings. In light of the Wendy Williams docu-series, one must ask a serious question about the professionalism of banks making CYS recommendations involving human and social welfare to the courts about care and guardianship of individuals when such recommendations need specialists trained and licensed to make that recommendation and decision. IT SHOULD BE HUMAN AND SOCIAL WELFARE WORKERS MAKING SUCH RECOMMENDATIONS to the courts. Furthermore, the CARE should include and involve FAMILIES. That has been the modus operandi of human and social services for decades, so what has changed, and what is going on? Recently, it was revealed that Wendy Williams's bank accounts were frozen and she was appointed an Independent Guardian to provide care and administer Wendy's affairs and life while her family was shut out, only to watch on the sidelines; orchestrated by Wells Fargo Bank acting as CYS Social Work Professionals making recommendation to the courts of this country who acted on that said recommendation without appropriating family statutes law and care that was best practice. Child, youth, and family services are geared towards keeping families together in a safe environment with minimal safety risks and hazards, especially when this involves children. Programs such as FGDM are utilized today to identify next-of-kin or family/community in place of state and punitive services to treat and keep the family together. Wells Fargo's decision to get the courts to strip the family from providing care and guardianship of Wendy Williams at a time when she needs family is a draconian solution that has only exacerbated Wendy's problems. There is child care but also adolescent and adult care whereby agencies respond to the children's and entire families' needs to help the adult become an able members of the community to serve themselves. Community and family. There are systems in place, but it seems as if in Wendy's case the established system was not used. Furthermore, it shows how the system and the private sectors work against already established best practices in human and social services in caring for the family. Banks and financial sectors should never make decisions about family care. The banks should have alerted the relevant care providers or make a recommendation. If anything the courts should have thrown out the case as the banks lack precedence and jurisdiction to make such a determination given their lack of training in this regard. Further, the courts should have never sided with the banks to block the family from planning and providing care for Wendy. This suggests collusion and corruption and is a step backward. Moreover, the HHS has been promoting family care in their assisted living programs and services, so the fact that the family is now involved in care to not disrupt the family connections which is pivotal to adult and CYS care and empowerment of individuals in the community. The docuseries, although hard to watch and said to be exploiting Wendy, was necessary as it revealed a truth about how the courts and banks work to shut out families from their family members' care against what CYS professionals promote. I hope that this will provide openness to discussing care and how banks must never get involved in such decisions. It also puts We... The rest of the article is discussed on this episode of The NeoLiberal Round. Y ou may also read it in The NeoLiberal Journals at https://theneoliberal.com/the-neoliberal-journals or The NeoLiberal Post at https://renaldocmckenzie/the-neoliberal-post. Subscribe for free! The NeoLiberal Round is a production of The NeoLiberal Corporation, serving the world today to solve tomorrow's challenges by making popular what was the monopoly. Visit us at https://theneoliberal.com and https://renaldocmckenzie.com. --- Send in a voice message: https://podcasters.spotify.com/pod/show/theneoliberal/message Support this podcast: https://podcasters.spotify.com/pod/show/theneoliberal/support

Trailer: Coming up after Super Bowl 2024: The @PhiladelphiaGov Office of Homeless Services is closing several transitional housing programs. according to David Fair former Manager at the City of Philadelphia and CYS chief, on The Neoliberal Round. Subscribe for free and support us at https://anchor.fm/theneoliberal/support. --- Send in a voice message: https://podcasters.spotify.com/pod/show/theneoliberal/message Support this podcast: https://podcasters.spotify.com/pod/show/theneoliberal/support

A 1-year-old child is dead after being fed waterbeads, batteries and acetone.  Aleisia Owens, 21, the girlfriend of the baby Iris'  father, had been arrested for intentionally feed the child harmful items.   According to police, the child died of organ failure, a result of acetone poisoning.  The baby's mother first took the girl to the hospital, after  changing he diaper, finding "water beads."  Over the next few days Iris passes about 20 water beads. She also passes 3 button shaped batteries, and a metal screw. After 4 days, the baby is able to go home with her mother.  Pennsylvania Child Youth Services, CYS, inspects the homes of both parents and, according to Newsweek, finds no issue at either residence. Iris lives with her mother fulltime, but she continues to visit her dad at his house where Bailey Jacoby lives with his girlfriend, Aleisia Lynnae Owens. During a weekend visitation at her father's house,  Bailey Jacoby goes to the grocery store, leaving Iris with his live-in girlfriend.    As he is preparing to check out at the grocery store,  Owens calls Jacoby and tells him that something is wrong with Iris, she isn't acting like herself, she is unresponsive. Jacoby tells Owens to call 911. Emergency responders  Iris breathing with a fixed gaze and weak response. She's transported to the hospital when she dies four  days later.   The homicide investigation heats up when investigators discovered Bailey Jacoby's live-in girlfriend, the last person to be with Iris alone,  Aleisia Lynnae Owens, has been researching online the harm that water beads and batteries can cause children prior to the child ingesting the items.  The Attorney General's Office confirms, Owens also conducted  online research into household items that could cause serious harm or death to children.   Forensic extractions of Owens cell phone show she searched online for topics such as ; “If your child drinks a lot of nail polish remover, what happens” and “What happens if a baby eats nail polish,” and “How many cases have there been from babies dying from eating nail polish.” Another search on Owens' phone was “In how many cases have kids died from eating water beads,” “water beads harmful,” “Water beads near me,” and “Beauty products that are poisonous to kids.”   During the days Iris Alfera was in the hospital as well the day after she passes away, investigators discover numerous online searches conducted on Aleisia Owens phone for information on how to pass a polygraph test.   Joining Nancy Grace Today Candise Alfera - Grandmother of Iris, Facebook: Iris' Angels Frank Alfera- Grandfather of Iris Jarrett Ferentino- Homicide Prosecutor in Pennsylvania, https://jarrettferentino.com, Host: “True Crime Boss” Podcast, Facebook & Instagram: Jarrett Ferentino Dr. Bethany Marshall (Beverly Hills, CA), - Psychoanalyst www.drbethanymarshall.com/, Instagram & TikTok: drbethanymarshall, Twitter: @DrBethanyLive, appearing in the new show “Paris in Love” on Peacock  Larry Forletta- (New Castle, PA) Private investigator and founder &CEO of Forletta Investigative Security Consulting, Fmr. Law enforcement, https://fcisllc.com  Dr. William Morrone- (Michigan)-Medical Examiner, Toxicologist, Pathologist, opioid treatment expert, Author: “American Narcan: Naloxone & Heroin-Fentanyl associated mortality”  Alexis Tereszcuk – (CA) CrimeOnline.com Investigative Reporter, Writer/Fact Checker, Lead Stories dot Com, Twitter: @swimmie2009 See omnystudio.com/listener for privacy information.

The Positively Remarkable Forum with Guest, Hema Mathew - Podcast 49 Hema Mathew CEO & Creative Director Bijhem DevOps  Positivity ServantTranscript  Cys Bronner: I'm Cys Bronner. I have the honor of being your co-host today. I am not just a BNI person, which I enjoy immensely as an Executive Director here in BNI Greater Los Angeles, but I don't know if you've ever noticed, my title here is Gratitude Evangelist, which I have been for more years. Then I can count and when I met Norm Dominguez who hosts here usually, I was also a Gratitude Evangelist and through the years and carrying on this relationship, I'm honored to be here with all of you as that to thank you so much and I'm excited to get started today. But here's the moment I've been waiting for. And that is our guest today is Hema Matthew. I know her through a chance meeting in my BNI world. She is the CEO and Creative Director of Bijhem DevOps. She's also a positivity servant. I would love to go on and on about her, but I'm not going to. As much as she touches my heart and is probably my new favorite top positivity people in the group that I know. I want you to meet her and have her speak to her and her topic today is Show That You Care. Hema Mathew: Thank you, Cys, for such a warm welcome and introduction. I just adore you. So, thank you.  Thank you, Norm, for having me. I am just honored to be here among other positive servants. You all are fantastic, and I feel like I've missed out all these years not knowing you all. So I'm so happy to be here. So, my name is Hema Mathew. I'm the CEO and the Creative Director of Bijhem DevOps. I have a business here in San Antonio. We do web development, digital marketing and mobile apps, web apps. We help small businesses get online presence and grow and scale. So that's what we do. So, a little bit about me. I was born in India. I was raised there in Chennai till I was about 10. And then my dad started his university here in Oklahoma and was doing his MBA. So, he just moved the entire family over here. So, from then we've been in Oklahoma. And I went to school at the University of Oklahoma, and I met my husband there at the tender age of 18 on the very first day of college, in the very first class. And he was this talkative guy and just extremely serious. He was a chemical engineering major, so extremely smart. We just hit it off right away. And we've been, we dated for 10 years and then we got married, and we've been married for 24 years, and he got recruited to the University of Texas here in San Antonio because they were trying to take small business ideas and take it to the market. And literally they've been looking for someone. To just come and help them do that. And they were looking for two to three years and anyway, they tracked him down in DC, so they made him an offer. So, we moved here, and it's been a blessing for our family. We love it in San Antonio. I love the city. I love the state of Texas. We had three small kids. No, not small anymore but see sweet kids. Our oldest is 20 and he's studying biomedical engineering. He's hoping to go into medicine. He wants to be a surgeon so and he's one positive guy. So, I I would love for him to join us one of these days because he's so positive about health about God and. And just inspires everybody around him. So, he's studying biomedical. Our second sBNI4Success Podcasts The Voice of BNI Greater Los Angeles; Where we'll talk about referral networking that works!http://bnipodcast4success.com

On this week's Marne Report Podcast, Child and Youth Services director Amber Eissler, breaks down the CYS respite care process that is available to families of Service members who are currently downrange. To learn if you qualify or to learn about the benefits, take a listen to this week's episode by searching "The Marne Report" wherever you get your podcasts.

Now that the WaterGuru does 5-test factors is this the smart water monitor that you can rely on? With daily FC, pH, ALK, Hardness & CYS you have the primary readings all covered.Leslie's Pro: Pool Service Pro, open a Wholesale account today! Customer referrals, free cleaner repairs, free water testing, open 7-days a week. It is fast and easy to become a Leslie's Preferred Pool Care Provider. https://lesliespool.com/commercial-services.html/?utm_medium=referral&utm_source=spll&utm_campaign=spllThanks for listening and I hope you find the Podcast helpful! For other free resources to further help you:Visit my Website: https://www.swimmingpoollearning.comWatch on YouTube: https://www.youtube.com/@SPLPodcast Site: https://the-pool-guy-podcast-show.onpodium.com/

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551778v1?rss=1 Authors: Ohno, Y., Nakamura, T., Iwasaki, T., Katsuyama, A., Ichikawa, S., Kihara, A. Abstract: Protein-bound ceramides, specialized ceramides covalently bound to corneocyte surface proteins, are essential for skin permeability barrier function. However, their exact structure and target amino acid residues are unknown. Here, we found that epoxy-enone (EE) ceramides, precursors of protein-bound ceramides, as well as their synthetic analog, formed stable conjugates only with Cys among nucleophilic amino acids. NMR spectroscopy revealed that the beta-carbon of the enone was attached by the thiol group of Cys via a Michael addition reaction. We confirmed the presence of Cys-bound EE ceramides in mouse epidermis by mass spectrometry analysis of protease-digested epidermis samples. EE-ceramides were reversibly released from protein-bound ceramides via sulfoxide elimination. We found that protein-bound ceramides with reversible release properties accounted for approximately 60% of total protein-bound ceramides, indicating that Cys-bound EE ceramides are the predominant protein-bound ceramides. Our findings provide clues to the molecular mechanism of skin barrier formation by protein-bound ceramides. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Coming up Later on The Podcast: Breaking News: Social service organizations that operate the Community Umbrella Agencies (CUAs) are at an impasse with the Department of Human Services (DHS) in Philadelphia; the government's super agency that oversees and fund the CYS programs.   In fact, some social service organizations are abandoning their CUA programs over an insurance requirement which the CUA's can't meet given limited funding and recent legal claims that they must pay out. One agency chief said: "we're giving up the CUAs as of August 2023...We can't afford the insurance.... The insurance costs are in the seven figures and DHS won't reimburse. It's a complicated story. They [DHS] have immunity because they are government, so we're the ones who get sued even when they made the error. The insurance costs are in the seven figures and DHS won't reimburse. It's a complicated story. David went on to reveal to us that "all four of our CUAs are being transferred to new agencies. Three will move as of August 1st and the fourth around Labor Day." David Fair, Deputy Chief of Turning Point for Children (TP4C). We will have David Fair on The Neoliberal Round later today talking about the state of child welfare (part 2). Subscribe for free! Donate to us to get us growing: The NeoLiberal Round • A podcast on Spotify for Podcasters Visit us and access Renaldo McKenzie's books, Neoliberalism, https://theneoliberal.com or http://renaldocmckenzie.com Submitted by: Renaldo McKenzie, Chief at The NeoLiberal Round and The NeoLiberal Corporation. Renaldo is also the author of Neoliberalism, Globalization, Income Inequality, Poverty and resistance. Renaldo is an Adjunct Professor and a Doctoral Student at Georgetown University. Renaldo has worked previously as a CUA Cae Manager and A CYS Agency Director at It Takes a Village FGDM program. --- Send in a voice message: https://podcasters.spotify.com/pod/show/theneoliberal/message Support this podcast: https://podcasters.spotify.com/pod/show/theneoliberal/support

April is Month of the Military Child! On this week's Marne Report podcast we chat with our friends from Child and Youth Services to learn about why the month is so special and what fun events they have planned. Take a listen now wherever you get your podcasts and don't forget to check out the Kids Fest event happening on Fort Stewart today!

Cys Bronner, BNI Executive Director, CRO and THE Constant Social Media Networker, discusses #BNI Core Value – GIVERS GAIN®We give because we understand that in a community, what we do, others will do, and we all benefit.Transcript:Hi, I'm Cys Bronner, BNI Executive Director for BNI's Greater Los Angeles regions, BNI4Success. Today, I want to talk about BNI's Core Value #1 – GIVERS GAIN®It should be no surprise that our first Core Value, is also the driving philosophy of BNI.   Over time, I've learned that Givers Gain® can mean many things to many different people. But ultimately, it's based on the age-old philosophy of “What goes around, comes around”. In my mind, it's more than a reciprocal tit-for-tat statement. It is how we lift up others around us. It's the philosophy of sharing the gratitude of abundance with our business partners. It's the benefit that even the smallest farmer knows, the garden grows best when the seeds are pollenated.When I look at our 7 Core Values, I also see that it's the strength within some of the others, like Building Relationships and even Accountability. Givers Gain® isn't just a throw away motto, it's a part of BNI's DNA. Everyone all levels understands that this is organizations guiding core value, and that's a pretty incredible thing to be a part of, isn't it?  If you're looking to gain more insights into BNI and really bring the most results to your chapter and business, let me be a part of your network.  Subscribe or follow BNIpodcast4success.com  I'm looking forward to hearing how Givers Gain® is woven into your life.  In networking: The more memorable (positive and helpful) you are, the better the results. Questions? Feel free to call Actionsteps4Success Founder and BNI Executive Director Cys Bronner 866-889-3466 or email her at Cys.Bronner@BNI4success.com Her motto: BNI, making word of mouth marketing work for youClick for more information or to join a BNI chapter in the Los Angeles area BNI4Success Podcasts The Voice of BNI Greater Los Angeles; Where we'll talk about referral networking that works!http://bnipodcast4success.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.07.531593v1?rss=1 Authors: Jose, E., March-Steinman, W., Wilson, B. A., Shanks, L., Paek, A. L. Abstract: The p53 and FOXO transcription factors (TFs) share many similarities despite their distinct evolutionary origins. Both TFs are activated by a variety of cellular stresses and upregulate genes in similar pathways including cell-cycle arrest and apoptosis. Oxidative stress from excess H2O2 activates both FOXO1 and p53, yet whether they are activated at the same time is unclear. Here we found that cells respond to high H2O2 levels in two temporal phases. In the first phase FOXO1 rapidly shuttles to the nucleus while p53 levels remain low. In the second phase FOXO1 exits the nucleus and p53 levels rise. We found that other oxidative stress induced TFs are activated in the first phase with FOXO1 (NF-{kappa}B, NFAT1), or the second phase with p53 (NRF2, JUN) but not both following H2O2 stress. The two TF phases result in large differences in gene expression patterns. Finally, we provide evidence that 2-Cys peroxiredoxins control the timing of the TF phases in response to H2O2. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.531332v1?rss=1 Authors: Sneddon, W. B., Friedman, P. A., Mamonova, T. Abstract: The Na+-dependent phosphate cotransporter-2A (NPT2A, SLC34A1) is a primary regulator of extracellular phosphate homeostasis. Its most prominent structural element is a carboxy-terminal PDZ ligand that binds Na+/H+ Exchanger Regulatory Factor-1 (NHERF1, SLC9A3R1). NHERF1, a multidomain PDZ protein,establishes NPT2A membrane localization and is required for hormone-sensitive phosphate transport. NPT2A also possesses an uncharacterized internal PDZ ligand. Two recent clinical reports describe congenital hypophosphatemia in children harboring Arg495His or Arg495Cys variants within the internal PDZ motif. The wild-type internal 494TRL496 PDZ ligand binds NHERF1 PDZ2, which we consider a regulatory domain. Ablating the internal PDZ ligand with a 494AAA496 substitution blocked hormone-sensitive phosphate transport. Complementary approaches, including CRISPR/Cas9 technology, site-directed mutagenesis, confocal microscopy, and modeling, showed that NPT2A Arg495His or Arg495Cys variants do not support PTH or FGF23 action on phosphate transport. Coimmunoprecipitation experiments indicate that both variants bind NHERF1 similarly to WT NPT2A. However, in contrast to WT NPT2A, NPT2A Arg495His or Arg495Cys variants remain at the apical membrane and are not internalized in response to PTH. We predict that Cys or His substitution of the charged Arg495 changes the electrostatics, preventing phosphorylation of the upstream Thr494, interfering with phosphate uptake in response to hormone action, and inhibiting NPT2A trafficking. We advance a model wherein the carboxyterminal PDZ ligand defines apical localization NPT2A, while the internal PDZ ligand is essential for hormone-triggered phosphate transport. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.30.525688v1?rss=1 Authors: Vamos, A., Arianti, R., Vinnai, B. A., Alrifai, R., Shaw, A., Poliska, S., Guba, A., Csosz, E., Csomos, I., Mocsar, G., Lanyi, C., Balajthy, Z., Fesüs, L., Kristof, E. Abstract: White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large amounts of mitochondria. The rs1421085 T-to-C single-nucleotide polymorphism (SNP) of the human FTO gene interrupts a conserved motif for ARID5B repressor, resulting in adipocyte type shift from beige to white. We obtained abdominal subcutaneous adipose tissue from donors carrying FTO rs1421085 TT (risk-free) or CC (obesity-risk) genotypes, isolated and differentiated their preadipocytes into beige adipocytes (driven by the PPAR{gamma} agonist rosiglitazone for 14 days), and activated them with dibutyryl-cAMP for 4 hours. Then, either the same culture conditions were applied for additional 14 days (active beige adipocytes) or it was replaced by a white differentiation medium (inactive beige adipocytes). White adipocytes were differentiated by their medium for 28 days. RNA-sequencing was performed to investigate the gene expression pattern of adipocytes carrying different FTO alleles and found that active beige adipocytes had higher brown adipocyte content and browning capacity compared to white or inactive beige ones when the cells were obtained from risk-free TT but not from obesity-risk CC genotype carriers. Active beige adipocytes carrying FTO CC had lower thermogenic gene (e.g., UCP1, PM20D1, CIDEA) expression and thermogenesis measured by proton leak respiration as compared to TT carriers. In addition, active beige adipocytes with CC alleles exerted lower expression of ASC1 neutral amino acid transporter (encoded by SLC7A10) and less consumption of Ala, Ser, Cys, and Gly as compared to risk-free carriers. We did not observe any influence of the FTO rs1421085 SNP on white and inactive beige adipocytes highlighting its exclusive and critical effect when adipocytes were activated for thermogenesis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.24.513629v1?rss=1 Authors: Wang, Y.-J., Di, X.-J., Han, D.-Y., Nashmi, R., Henderson, B. J., Moss, F. J., Mu, T.-W. Abstract: Protein homeostasis (proteostasis) deficiency is recognized as a contributing factor to many neurodegenerative, neurological, and metabolic diseases. However, how the proteostasis network orchestrates the folding and assembly of multi-subunit membrane proteins is not completely understood. In this investigation, we focus on characterizing the biogenesis pathway of a multi-subunit neuroreceptor, the gamma-aminobutyric acid type A (GABAA) receptor. Previous proteomics studies identified Hsp47 (Gene: SERPINH1), a heat shock protein in the endoplasmic reticulum lumen, as the most enriched GABAA receptor-interacting chaperone. Here, we show that Hsp47 enhances neuronal GABAA receptor functional surface expression, acting after Binding immunoglobulin Protein (BiP), to preferentially bind the folded conformation of GABAA receptors. Therefore, Hsp47 promotes the subunit-subunit interaction, the receptor assembly process, and the anterograde trafficking of GABAA receptors. These Hsp47 properties are also extended to other Cys-loop receptors, including nicotinic acetylcholine receptors. Therefore, in addition to its known function as a collagen chaperone, this work establishes that Hsp47 also plays a critical and general role in the maturation of multi-subunit neuroreceptors. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

INTRODUCTION: Jenn has a story of her own. As a child, she suffered solitary confinement, physical abuse, mental abuse, sexual abuse, rape, divorce, abortion, cutting, and suicide attempts. Her turbulent background has forged a path to help those who are suffering, ignored and silenced. Sh!t You Don't Want to Talk About is a place people can come to find hope and healing, to know they are not alone, and to finally be heard. Clearly, Jenn's been through plenty of sh!t most people probably don't want to even acknowledge, let alone talk about. She thought she'd dealt with her past, but brain surgery in November 2020 unleashed a tsunami of memories that couldn't be ignored. Working through trauma, depression, anxiety, bipolar type 2, and ADHD will be a lifelong journey. Jenn strives to break the stigma of Sh!t You Don't Talk About and turn it into Sh!t 2 Talk About.  INCLUDED IN THIS EPISODE (But not limited to): ·      Jenn's Take On The Herschel Walker Hullabaloo ·      Jenn's Homeless Youth Experience·      Consent Matters!!!·      The Resurgence Of Forgotten Trauma·      Be Mindful Of Your Perspective When Bad Things Happen·      How PTSD Affects Both Military And Non-Military Folks·      Living Through A Lifetime Of Surgeries·      Jenn's Smokin' Hot TikTok·      Let's Give Ourselves More Credit·      Let's Accept Our Limits CONNECT WITH JENN: Website: https://www.Shit2talkabout.comLinkTree: https://linktr.ee/shit2talkaboutTikTok: tiktok.com/@shit2talkaboutLinkedIn: https://www.linkedin.com/company/shit2talkabout/YouTube: https://bit.ly/3BRnT50Facebook: https://www.facebook.com/shit2talkabout/Instagram: https://www.instagram.com/shit2talkabout/Twitter: https://twitter.com/shit2talkabout  CONNECT WITH DE'VANNON: Website: https://www.SexDrugsAndJesus.comWebsite: https://www.DownUnderApparel.comYouTube: https://bit.ly/3daTqCMFacebook: https://www.facebook.com/SexDrugsAndJesus/Instagram: https://www.instagram.com/sexdrugsandjesuspodcast/Twitter: https://twitter.com/TabooTopixLinkedIn: https://www.linkedin.com/in/devannonPinterest: https://www.pinterest.es/SexDrugsAndJesus/_saved/Email: DeVannon@SexDrugsAndJesus.com  DE'VANNON'S RECOMMENDATIONS: ·      Pray Away Documentary (NETFLIX)o  https://www.netflix.com/title/81040370o  TRAILER: https://www.youtube.com/watch?v=tk_CqGVfxEs ·      OverviewBible (Jeffrey Kranz)o  https://overviewbible.como  https://www.youtube.com/c/OverviewBible ·      Hillsong: A Megachurch Exposed (Documentary)o  https://press.discoveryplus.com/lifestyle/discovery-announces-key-participants-featured-in-upcoming-expose-of-the-hillsong-church-controversy-hillsong-a-megachurch-exposed/ ·      Leaving Hillsong Podcast With Tanya Levino  https://leavinghillsong.podbean.com  ·      Upwork: https://www.upwork.com·      FreeUp: https://freeup.net VETERAN'S SERVICE ORGANIZATIONS ·      Disabled American Veterans (DAV): https://www.dav.org·      American Legion: https://www.legion.org ·      What The World Needs Now (Dionne Warwick): https://www.youtube.com/watch?v=FfHAs9cdTqg  INTERESTED IN PODCASTING OR BEING A GUEST?: ·      PodMatch is awesome! This application streamlines the process of finding guests for your show and also helps you find shows to be a guest on. The PodMatch Community is a part of this and that is where you can ask questions and get help from an entire network of people so that you save both money and time on your podcasting journey.https://podmatch.com/signup/devannon  TRANSCRIPT: [00:00:00]You're listening to the sex drugs and Jesus podcast, where we discuss whatever the fuck we want to! And yes, we can put sex and drugs and Jesus all in the same bed and still be all right at the end of the day. My name is De'Vannon and I'll be interviewing guests from every corner of this world as we dig into topics that are too risqué for the morning show, as we strive to help you understand what's really going on in your life.There is nothing off the table and we've got a lot to talk about. So let's dive right into this episode.De'Vannon: Jenn Junod, the host of the shit you don't want to talk about podcast is back with me for round two, y'all. Now, in this episode, we're gonna be reaching deeper into Jen's experience with mental and physical health problems. We're also gonna get to hear Jen's take on the current Herschel Walker scandal that's happening right now.Yes. Hmm. Go ahead and listen people. Hello everyone, and welcome back to the Sex [00:01:00]Drugs in Jesus podcast. I'm wearing my shirt tonight that says, Be the light. I hope that Jen and I can shine a little light on y'all's darkness today if you're going through a dark time. Now, Jen is the host of the Shit You Don't wanna Talk About podcast.She's been on the show before and now she's back again to to dig a little bit deeper into her personal journey. Jen, how are you today? Jenn: Well, I, I like to say people really, especially in the tech industry, which is where I'm at now, really compare, like, do you want a zip up hoodie or do you want like a pullover hoodie?And most people want like a zip up hoodie because it's easier to take on and off. And I'm using that as an example of I am wearing my pullover hoodie and I always get them like, Really snug because when I'm not feeling will [00:02:00] go with pep as a good word, when I'm just like not feeling it, I always put on my pull over hoodie because it makes me feel safer and it makes me feel like more snuggled just walking around.And that is how I'm feeling today, that I need a little, give myself kindness and grace and not trying to push myself to have a lot of energy today.De'Vannon: Well, I share the fuck. Appreciate you coming on the show before we mash that record button you were expressing how you were on the fence about whether or not we should postpone or whatever you decided to just push through to show people truth.You know, we don't always have our shit together every day. Hell, I went to the weight loss clinic today to to get like the, one of the weight loss injections and I decided to keep on my fluffy winter flip flops, you know, just to be like, relax and shit. Which is something a fashionist, a diva like [00:03:00]me has never done before.I even wore them last night to go get a massage. And so sometimes just wanna go to the house with fucking roles in your head. Shit. Fuck it. Be done with it. . Jenn: Yes. Yes. I agree. I agree. De'Vannon: And so so y'all, in the Today Show, we're gonna be talking more about Jen and digging deeper into her mental health issue.In the last show she talked about like the abortions and the, the, the, all the abuse and the trauma and the drama. So much drama, you know, that she's been through growing up and, you know, and what prompted her just on her own podcast and the shit you don't want to talk about podcast. All that information go on the show notes.And I know she does her Twitter sphere Jenn: thing stay Yes. Twitter De'Vannon: space in the Twitter sphere, every Tuesday or think most win. And so be sure to catch her there also. And I look forward to the day when her memoir comes [00:04:00] out. I'm just gonna like, speak that into existence. Jenn: It will, it will one De'Vannon: day. And so, okay, so I'm gonna get your opinion on this dude who's been really popular in the news.You were so transparent about your abortions and everything last time. Have you heard of everything that's been going on with Herschel Walker? Jenn: Okay, so y'all, I don't, I live in like a bubble is what I've decided. I don't really know what's going on unless somebody tells me about it. But I'm, I'm Googling and that is the first person that came up.De'Vannon: There is nothing wrong with going to the Google machine and finding out what you need. And so basically this man is running for a Senate seat. He he's one of those backed by Republicans. Pro, pro-life, anti-abortion people and, hi, his, his thing is he's against abortion with no exclusion for rape, incest, anything like that at all.[00:05:00] Just period. But come to find out, he paid for his own abortions back in the day, has a couple of baby mamas and he don't take care of the babies and his own son, who's a social media influence or can't remember that pretty little thing's name right now, but it'll come to me, came out against his own dad.He was like, You need to shut this shit down and stop because you fake his hell. And so from the abortion standpoint, because these women are coming out, going like, one was like, he forced me. He wanted me to get the first abortion, so I did. But the second one, I told him to go fuck off and decided to keep the kid.And so, you know, I just wondered like, what, what, what you think these women might be going through? Seeing the man who wanted him to get the first abortion. Lying, lying to everyone saying, Oh, I don't remember any of this. But he wrote the check to pay for the abortion and then sent the woman a get well soon cardJenn: So it's I actually just listened to our other episode [00:06:00] and interesting timing of listening to that. I, I talked about how during my first termination, I, I felt forced, but it's not like anyone could do anything about it. It was a very I had to think about what that kid would've gone through to do it.And I, I would say for what this human hersel do, dad is doing, I don't think anyone should go into politics and. Forget about what they used to do. I personally think if somebody did something fucked up, then they should own it and say, This is why I just, I changed my ways, first off, second. I can only imagine what it felt like to be [00:07:00] paid to go get an abortion.I have been there. And and then third, I think scariest yet is the fact that there are people in wanting to gain power that want to gain ownership of our bodies. And in my opinion, that's the scariest part in the fact that as someone that has. Like the, the woman that you used as an example, she said yes to the first one that said, fuck off to the second one.I feel I, and again this is just my imagination, but I feel like she would be very empowered because she, she told him fuck off, and that is her taking back her power. And I think it's a very, very complex level of[00:08:00]fear when your, the person that caused your trauma has power not only over you, but over others. And it's, I know for myself it's been. I don't give a fuck what you did to me, but if you do it to someone I care about, if I see you doing it to someone else, I go into like overdrive of, I won't let them feel that way.And I could see some of the women possibly feeling like that, but then also going, I'm glad that I stayed silent because they're so afraid of what might happen to them, what might be taken away, what might be threatened. And there are many, many complexities that I can't even imagine about. Maybe he's secretly paying some of them.And what would happen if [00:09:00] they don't get the paycheck anymore? Are they gonna be able to feed the rest of their kids? What would happen if, you know, if they do talk about that they went through an abortion and now they are succeeding in their life, even though he forced them to do it, Wouldn't that be controversial for them saying that?They were against it, but almost happy they did it. It's, I mentioned this in in the other episode that I don't think anyone could imagine what someone else would feel about it unless they went through it. Because it is, there's so many complexities that go into this, De'Vannon: Well, you're pretty damn good on, on postulating and guessing at the complexities.It's like you're able to really, really put yourself in other people's shoes. So that strong level of empathy that you have is why you're so, such a great host and so great at everything you do, and basically given the world the big warm hugs like you do on a day to day basis. Because I hadn't thought about, [00:10:00] you know, like what if he was, I mean, he's been lying through the whole candidate candidacy, you know, clearly.But what if he really was paying them? You know, he's saying to the camera, I don't know, these bitches, whatever. Mm-hmm. . But really he's been bankrolling them and, and, and out of fear they've kept quiet because that's like a quiet control he's had over him this whole damn time. You never damn know the thing.Jenn: I, I do wanna add one other thing just because I also like to go into conspiracy things because I think partly it's very entertaining for myself is the fact of, so for those of you that may be like me that have no idea who Herschel Walker is and is Googling shit just something that is a very, very uneducated guess could be that if you have a person of color that has been given money and want to set an example, are they doing it and [00:11:00] doing it the way that others are telling them to because they want to be able to show that others can do it.even if it just disrupts their morals,De'Vannon: anything's possible. But what most commentators seem to believe is that Herschel is somebody who is mindless enough to be a yes man for the Republican party if he gets elected at the Senate. Because if you hear him talk, he used to be an NFL player, that he hit his head one too many damn times that he talks like he still has a fucking concussion.He's just like well and so he is the Plato for them. And so that's why, and I agree that's probably why they have him up there. And the thing is, we wouldn't be judging him for his shady pass if he wouldn't have judged the women first. And if, and if he wouldn't be throwing all the women under the bus for, for, for doing this.But what, you know, women can't get pregnant by themselves. Jenn: That's what I was just thinking, , like, you can't do it by [00:12:00] yourself. It's, it's, you know, we're not what Horse. Wait. Star, Star, What are the fishes that like self impregnate themselves? Horse fish, De'Vannon: sea horses, you think? Jenn: Yeah, that's what I'm trying to think about.Sea horses, horse fish. You know that horse too? De'Vannon: I know God. Ze can impregnate himself. He has all the power, so that's why I've always looked up to him. And the, the, the, the other fucked up part, and we're gonna pivot away from politics in just a moment, but you know, this is such a hot button topic right now.The bitch is over on, you know, like Fox News and the conservative commentators, you know, one of them, I can't remember this whole's name, but she was all like, I don't care if he had abortions, if he Aborts Baby E was on television. He was like, I want to get control of the Senate. And she was like, The women are skanks, but you know, The, the Republican party, like the women are gangs.The women [00:13:00] are the trouble, but the men, they get forgiven. Oh, he's changed his past will give him a second chance. But the women, but they're like, Oh no, that ho, You know, And the Republican party isn't even trying to hide this hypocrisy anymore. Yeah. Jenn: That I mean, I started listening to part of your episode on the cold Christianity, and that just reminds me, there's, there's so much that goes into that and I, Yeah.I disagree people, Some people are douche bags is all I can De'Vannon: say bags all the way. Yes. Goddamn fucking motherfucking D bags. So talk to me about when you were homeless before. Jenn: Oh, okay. Just you said we were gonna pivot. We're gonna pivot. I don't talk about it much [00:14:00] because when I look back, I didn't need to be homeless. That is something that I didn't realize then. If I going back then so listen to episode one to, you know, catch yourself up on my story because I'm not gonna repeat it all, it takes forever. , I was, let's see, I was sexually abused from my cousins from the ages of eight to 10.So my junior year of high school, I, the summer before is when I. Was listening to an Adam Sandler song, the shampoo bottle one, and Up the Ass and in the Car did not remember anything about my cousins, and it all flooded back to me. [00:15:00] All of it, just after like six years, didn't think of it. It all came back and my older cousin was now over the age of 18, so, and it had been out of the, out of five years, so it, they were like, We can't do anything.The cops were like, Yeah, whatever. We can't do anything. But my younger cousin, who's two years younger than me was about to start at the same high school I was. So little did I know how not awesome my dad is. Believe me, my mom tried to tell me she did. She, she has tried to tell me. But at that point in my life, I'm 1516 and I'm like, I've always wanted to have a relationship with my dad.I totally can do this. Like, I just wanna move in with him. He's promising me to get a car. He's promising that he'll get me a laptop for school. He promised that he'll finally like, pay for my boob job because, and y'all, I'm pausing there. It's not [00:16:00] just like a 16 year old wanting to get a boob job. My left rest never developed.I was named lo. So like there was a sincere reason why I wanted a boob job that young. Okay. Anyway, moving past that I did not know the type of or believe the type of.Manipulation and abuse that I would be walking into. When my parents were together, my mom was majority of the buffer, and they were together until I was 12, so it'd been four years. And basically the four, those four years, I was avoiding my dad. And so this was all new to me. And I moved in and he took off the facade of this charismatic person.He loved mom me. That is the best way of explaining it. And when I got there, it was [00:17:00] none of the problems is he made, came through one excuse or the other. He started isolating me again, just like he did when I was a child. And I was very, very fortunate in the fact that I. The person I was dating and his friends were like, We're not giving up on Jen.Like that's a bad area. So they would help me like sneak out on the weekends and help like come out and visit me even though I was 45 minutes away and I eventually said, You know what? I'm out. I'm moving. And I just, they all came and got my stuff and I just was like, I'm moving to back to Po. Patello where I was living.And I was, it was the beginning of my senior year at that point. My dad said, Well, you're truant. You're gonna you're gonna be arrested because of this, [00:18:00] cuz you're not going to school. And my boyfriend's at the Time's grandmother was like, you know, she can live with us. And she's like, I'll take power of attorney and take her, make sure she goes to school.Literally to this day, one of these weakest women. Who made such a big difference in my life. I moved in with her and her grandson and I we were very on again, off again, and by probably by Thanksgiving. So beginning of senior year started probably August. So by Thanksgiving we were done. And I thought that because he and I broke up that I could not live with her.I honestly, sincerely thought because if somebody didn't wanna be with me, other people wouldn't love me [00:19:00] and I didn't really have anywhere to go, even though logically looking back, yes, I eventually figured it out. I moved back in with her and stopped this chaos yet My senior year, I spent more time on in new beds than I did in my own car.I spent time becoming whoever anyone wanted me to be, just to not have to sleep in my car that night. And it, it was the type of thing that I don't remember a lot of my senior year there was a lot of drinking and I definitely was promiscuous. It was[00:20:00]also the year I said no, and I got roofied. Luckily the, the guy I was dating, I apparently called him and. He was able to find out from many other people where I was. And I was on a counter in the bathroom with three p three guys trying to undress me. And not even a month later, I went out with my soon to be roommate and she's a drinker and a partier and she, she loved to sleep around.She would brag about it all the time. And I said, No. And this guy kept trying to convince me, Well, it'll be alright. It'll be fun. And I fell asleep and I woke [00:21:00] up to him not listening to my no. And it's a really confusing time in the fact that I was. Sleeping with people to keep a roof over my head. And the two times I said no, people didn't listen.And it had a lot to do with why I couldn't comprehend, why I could have stayed at my ex's grandmother's house. She didn't care. She just wanted to love me. And it was a really difficult time in my life that my dad to this day still hasn't kept any of his promises story for another day. But my mom came up to help me get my license.My mom [00:22:00] helped me get my boob job so I could wear my dress for my senior prompt. She also got me a laptop. And I know we talked about my mom in the previous episode, but she always tried to do what my dad promised and never went through with too. But yeah, , De'Vannon: some people not to be parents. Jenn: So I agree. I agree.I thought I had tissue box in here. Apparently I don't. That's okay. De'Vannon: We have time. You can pause and go get it. We can pause and go get it if you want. Jenn: Sweatshirt. I'm not, You can keep this all the recording. I don't even care. Cause y'all life is fucking messy. It's not pretty. It's not. I mean, yes. Lots of life is beautiful.Yet, if we don't talk about this shit, how are we gonna realize that we're not [00:23:00] alone? De'Vannon: Yeah. Oh my God. A rough time in high school. You know, that's a lot to be going through, you know, then trying to focus on grades and everything like that. I'm so sorry. All this happened to you. I'm excited for the boob job, you know, and you know and so I heard you when you said that you did not need to be homeless.And that resonated with me because I feel the same way when I look back over when I was homeless, you know, in Houston. And so, you know, I had friends, you know, I was, you know, a, a, a veteran, but I didn't know about veterans programs at all. Cause I wasn't going to the VA for anything because in those days they were a nightmare.And And so I, you know, sometimes I think about that and I go, What was the difference? It was in [00:24:00] my mind and the way I perceive things. Mm-hmm. , so I could have called my parents to come and get me. I mean, I could, I could have, I did not have to do that, but I thought I was dying anyway. And so what, what, what is Jen?What are Jen and I saying to telling to you all is to be mindful of your perspective when negative things happen, and sometimes when you, Exactly. Sometimes when you think you're thinking straight, you're really not thinking straight, especially right after something bad has happened. Or even if it's a while, if there something bad is happening, you don't have that shit resolved.So then what can you do? Jen's gonna give you her suggestion, , My suggestion is to have somebody who you lean on or somebody who you can at least go to and be like, Bitch, I'm fucking up. I don't think I'm thinking straight. I need to bounce this idea off of you and be sure, I don't know. What would you, what would you suggest if somebody is in that situation?Jenn: I definitely agree and [00:25:00] I, I've heard the term like a lot or to like keep a journal and I'm like, Bitch, I'm not gonna keep a journal. Fuck that. Like I hate no now, but I am cognizant of. Working on tracking my patterns. So whatever way you track your patterns, I say that in the fact of I'm currently job hunting and I had a great day yesterday.I don't even remember what day it was. Like I had interviews that were going great. I had a guest on the show that was phenomenal. Like literally, everything is going so good and I'm miserable. Why am I miserable? I don't know. I have no idea why. I know because I keep track of these things that I do get depression.I am bipolar, type two, I am. These [00:26:00] things just happen and I've learned that. I need to be able to know, okay, am I just gonna check out and. Sit and play video games is, that's what's gonna help me get through this. Is it I need to go for a walk? Is it I need to have call one of my best friends? Is it I need to tell Tyler that I need all the cuddles in the world.What is it that I need to get through this? Because right now I feel alone, even though logic shows me I'm not alone. And it's very, very difficult to realize that. And I would say a big step of it is just tracking your patterns, because that will show you who am I happy around? Are these people that I'm [00:27:00] associating with?Am I miserable around them or am I happy around them? Do I feel like shit when I eat this certain food? It's weird. I found out that I am gluten intolerant. Like I can't eat gluten, but y'all, it fucks with me. So I know not to eat gluten. How do I feel if I don't exercise for a while? Does it really help or is it just because I wanna do it cuz everybody else says it?Like, what are things, How, how do I do life naturally and what are things that I want to improve on? Or what are things that I'm like, you know, fuck it. I am a sweetaholic so I'm gonna keep dark chocolate chips in the house instead of candy because if it's candy it'll be gone in a day. That's just who I am.I can live with that. De'Vannon: I'm a sweet aholic too. And I there's a basket I keep in the corner of the, like by like [00:28:00] by the patio door. And I found that if I just throw all the sweet shit in there, I don't. I won't go and reach for it, like it's in the pantry or somewhere like eye level. So this is down on like cat level and, and so , so these for me to forget about it.And then, so every now and then I'll remember, oh, there's a bucket of sweets over there. That way I don't feel deprived, but I've also placed it out of punch as a reach of myself. I Jenn: like it. I like it. I'm gonna do that without, I'll try it. Well, I'll see if that happens. And that's another, that actually brings up a really good point is once you find out these patterns, or even if you're not sure what they are, just trying something on seeing if it works.Like I have no idea if what you said is gonna work for me, putting it in the corner like I am, be like, Oh, D was right, this is like perfect. Or this is shit. It doesn't work for me. I'm not gonna do it anymore. But I tried it on to see if it's a [00:29:00] tool that will work for me. De'Vannon: Now, would you suggest that sort of strategy with dealing with all of the issues that you've talked to, talked about today?You know, what? If somebody has a barrage of negativity that their mind had closed off, you know, shut off the memory because of it was so traumatic that their brain cut it off of them. And what if it comes back? What do they find themselves in a, a rape situation? You know, do you recommend these sort of tools or what?Jenn: That one I think,De'Vannon: I mean, of course they can always reach out to you. You don't think decided every thing. Yeah, no, absolutely. Jenn: It's, it's the fact of dealing with ptsd and I know that so many people thought that it was only military that went through it. And I do not wanna take away from what our veterans have [00:30:00]gone through.Any, any force because even if you don't get shipped abroad, the military goes through some dark shit just through bootcamp and PTSD can affect us all in its posttraumatic stress disorder. And I say that as I did not realize I had PTSD until I had my brain surgery because that's when all my like memory slid it back.And I started having a lot more body reactions in the fact of you bring up the rape victim. I, the majority of my abuse was from people I trusted when, from the ages of eight to 10. And so if somebody that I trust tries to touch me at times, I go into fight or flight, it's very fucking annoying. and I'm still working through it yet by going to therapy, by going [00:31:00] to group help.Those are things that really help me get through it. It's also something that is not gonna go away anytime soon probably. Or it might go away for a while and it might come back cuz mental health is like, you know, it's not linear. It likes to be all over. And I would say just if it happens, especially if it happens in public, if it happens when you're driving, if it happens in those types of situations.First, please get yourself to safety. Please try to think about that first. No matter what is happening, it's not always possible to do this yet. Please get to safety and then who cares what the fuck you look like. If you are pulled over somewhere safe and having a meltdown, if you're in the middle of a grocery store having a meltdown, who the fuck cares if you are safe?Nobody's gonna hit you. Nobody's gonna run into you. Nobody's gonna do anything to you. [00:32:00]This is not always feasible, though. This can happen when you're doing other things and I don't know the resources to that. I'm happy to go look it up, but this is why I highly suggest at least having a relationship with a therapist you trust.Because I stopped going to therapy. Oh goodness, probably January this year and, but I still have my therapist number. So if shit hits the fan, if something happens, I can be like, Yo therapist, I need help. Or my family members know, I don't know what fuck just happened to Jen. She just like melted. Could you come like, Put her back together, please.De'Vannon: Mm-hmm. . Yeah, it's come and put me back together, Lord Jesus. Yes. So I do, I I would always recommend journaling and all your suggestions are phenomenal and so heartfelt and I appreciate the fuck out of them. And again, people can still reach out to you and [00:33:00] see what, we'll see what can be done see what can happen.I've started doing mdm, a assisted therapy with a social worker and also cell assignment therapy with a social worker for like my ptsd, ocd, anxiety and all of that. I recommend some of this hallucinogenic therapy to y'all cuz the, the drugs they prescribe. But in these clinics for me, re react very negatively with my system that I get from like a psychiatrist and shit like that.The hallucinogenics I've had a more positive results with. And so I walk away from them like I, when I've been on those trips. I don't feel like so out of body. I, my mind was just still, And for me, that is a strong deliverance because my mind is usually not still. And so that quietness followed me out of the therapy.And it's the same thing with me and like CBD gummies, because my body doesn't react to smoking weed at all, no matter the strand. But it does re [00:34:00] respond to the gummies. And so I take it as like a form of therapy. And I find that the quietness, my mind remembers it when I'm no longer under the influence of the drug.Jenn: I, I wanna add to that too in the fact that, as we were saying before, do what finds best for you. I'm biotech type too, which I found out is like, if I take drugs, it doesn't fuck me up in a good way. It fucks with my head bad. And so if I smoke weed, I'm probably ki crying in the bathtub. It's, it's not cool.Like I've been, I've talked to multiple the psychiatrists and I'm like, So I kinda wanna do lsd. And they're like, Please don't. It's just going not in the fact of like, please don't in the fact that, you know, all this is experimental. But because they're like, studies show that if you're bipolar type one or type two, you have [00:35:00] adverse effects to drugs because your brain already, the chemistry in it will not react properly like most people do.And I'm like, Oh, that makes sense because I've tried different things and it fucks with me where you talked about that you don't take the medications that a psychiatrist may prescribe. Those help me, but I know that they can fuck up other people. So please try and like have a. A buddy and on to go like, make sure you're doing okay, no matter which one you're trying.De'Vannon: Appreciate, sister. And so I heard you mention, you, you mentioned earlier like it was, it really, really hurt you because of people you, you trusted were, were some of the ones who had turned on you and And I just wanna to just pivot for just another, just another quick pivot and just us sin heart. Heartfelt warmth and love for people who feel that way [00:36:00] towards the church.We're not gonna go down a, a whole religious thing cause we did that on the last show and I appreciated it deliciously and delightfully. So, because, you know, we go to churches, and I was thinking about this earlier, you know, the only time we saw Jesus, like get up in arms, he tied that cord together and went in the temple and brand the people out who were like taking advantage of people, you know, in the house of God.And I was thinking, you know, he didn't go chasing down homosexuals or women who want abortions. And he didn't even much go chase the people who were swindler and cheaters outside of the church. He went into the church because it's bad enough that it's happening. But in a place like that where it's not supposed to happen, Is like the thing I think that really pissed him off.And so whenever we are expecting love from a place where it's supposed to come and we get hate, rejection, and pain, it's a more bitter pill to swallow. And so for all of you who have ever been heartbroken by somebody who you expected to treat you right, I'm sorry. I send you [00:37:00] love and peace and yes, fuck you, Lakewood Church because you were the ones who broke my heart and did that shit to me after our long relationship with each other.You mentioned that brain surgery. Tell, tell me why you had to have brain surgery. Jenn: Sure. So I think going through all my surgeries might make it a make a bit more sense. I am 2022, I am 34 and I had surgery number 10 this year. So me and surgery is not that scary. Let's see if I can remember all of my, I don't know if I can do them in order.Maybe I can. Okay. We're gonna see if I can do this. All right. So, Nope. I got, when I was little, little kid, I got tubes in my ears, which I didn't know was considered a surgery, but I guess it is. So I'm gonna count it. And then when [00:38:00] I was 13, I I was getting chronic bronchitis and they were noticing that my tonsils were causing it, but it's very, very dangerous to take out your tonsils when you have a any lung infections.So, but I wasn't gonna get better cuz I'm hardcore asthma and they they did it and I coded, which is a really weird experience because I like, remember looking down at myself. Very bizarre. Anyway, so that happened. I had my tonsils taken out, and then I had my gallbladder taken out, and then I had my first boob surgery when I was 17.And then I had an umbilical hernia, which basically because I [00:39:00] got my gallbladder out through my belly button, the scar tissue caused a hernia on where my umbilical cord would've been with my belly button. So that's why it's called an umbilical hernia. And it didn't go through. So I got another surgery for that.Oh, I'm missing one. They couldn't pull my teeth with me awake for my wisdom teeth, so they had to sedate me for it, like all the way out, sedated to what? What else am I thinking of? Oh, sinus and no surgery cuz I couldn't breathe out of my nose, brain surgery and in another boob job because it wasn't very good at when I was 17, so I finally got them nice.10. Yeah. So brain surgery was 2020 not the biggest deal. Me and going to [00:40:00] surgery is not a big deal. I'm just like, Oh, I have to have another, Okay, whatever. I've grown up around doctor's offices because I was su such a sick child. I was constantly hospitalized for my asthma and I got pneumonia a lot and bronchitis a lot.I was a really fun kid and it was around the age of three to four that my skull. Started forming a bump on my right temple and my mom was like, The fuck is going on with my daughter. So we lived in Phoenix at the time, and she took me to the hospital. They did MRIs and CAT scans and all that, and they found that my I had OID cysts on my brain.And an OID cyst is CYS is just like fluid. [00:41:00] It's just like a, if you take a bubble and it's on my the OID cyst is on the, between the brain and the spider webbing around your brain. And so they found it when I was like two or three, and they were like, Yo, don't worry about it. Most children, if they get it, they don't really know where I got it from, but they're like, Most children will grow out of it.Don't worry. So fast forward till I'm like eighth grade, so like 12, 13. And I'm in my mom's room for some reason, and I look in the mirror and I finally realize like, why is my temple so weird? And I'm like staring at myself like, What the fuck? Like as like a 13 year old, like this was mind blowing. I didn't know what it was, but it didn't really ever affect me other than I was like, I have this out.It looks really weird. I hate [00:42:00] it. Not a big deal. Very cosmetic, whatever, around the age. 20 something like, give or take. A year or two I started getting really, really bad pressure, headaches where I would have to tie a scarf around my head, cut off circulation to everything else, and. Like try to get rid of the pressure on my right temple.That happened a few times every year, maybe like not consistent enough to do anything about it or be concerned. I just thought I have all these medical conditions, I'm just probably a freak and it's another one of those things. I don't care. And in 2020 it started happening weekly. Okay, this is weird. And you can't really do anything.Like you can't work, you can't do much. And I was getting to the point where I had like this [00:43:00]giant jar of change that I would lay down on the bed with my head on the pillow and put change on my head to put like enough weight on it to try to get rid of the pressure. And I'm like, Okay, I gotta get this taken care of.Like this is, this is. Causing issues. And I'm like, Okay, I'll make an appointment, blah, blah, blah. I made an appointment with a neurologist and they're like, Yo, bro, try taking these like migraine medicines. Okay. Didn't fix it whatsoever. And then they were like, Don't worry about it. It's fine. A reference or nothing, don't worry.And so I'm, this is when my sister started working with me and were driving to work together and I'm driving and I have to pull over because my vision went away and I couldn't see all I could. It was just like, went all [00:44:00] black and the pressure was so bad, like I'm crying because it's just hurting so bad.So she finishes driving us to work and my partner came to pick me up cuz she needed to stay in work and they finally were like, Okay, cool. You can go see a surgeon. Well, I'm back in Phoenix at this point. And the same borrow barrow brain surgeons are in Phoenix or super dope, highly suggest them. I bring in my records to them cuz I still have the records, which, Oh yeah.Give me a second. You wanna see this? This is cool. Okay.Okay. I have the original scans from when I was a kid. Let's. I don't know how I'm gonna do this. De'Vannon: You probably have to have a light Jenn: behind it. I know. I'm like trying to think if I can do, Oh, I kiss the like, like this. Eh, eh, let me turn on my flashlight, bro. [00:45:00] Oh wow. Okay. Yeah. Okay. So, Oh, see, you can see where my eyeballs are, right?Yeah. And you see that giant, that big thing? Yeah. And then you can see one in the back of my head too. Yeah, yeah, yeah, yeah. These are from when I was a kid.De'Vannon: Okay. And they just like left that there. Yeah, Jenn: because normally they go away naturally. Normally assist is like no big deal. So that's the one that's still there. It's actually grown. And so , I get so excited I bring these into the neurologist or the neurosurgeon with me and I'm like, Look, And they're like, We're not gonna do anything about it.No. They're like, It'll just go away. This isn't normal. Like, or this, These are routine things. No big deal. So they go and they're like, Hey, go get lidocaine shots. See if that helps. So I have to wait until one of these things normally go. Then I have to go into the doctor and get a lidocaine shot, which [00:46:00] is just numbing serum.And so they put a ton of lido and I'm like, It's not going away. And so it's not the pain at this point that's hurting. Like, yes, it hurts, but I'm crying because they can't figure it out. And at this point I'm thinking, no one will believe me. So I think I'm stuck with this for the rest of my life. But after further, they actually took it to like the board of Surgeons at the hospital.And they were like, Yo, like this isn't normal, that she gets headaches from this. Like she's going through so much. So they did a experimental surgery. What they did is if you think of a lake and then you think of this like randomly fluid as my river, as a river, they took my lake of a cyst and created a scar tunnel into the regular, like brain fluid that just chills in your brain.So as of it's [00:47:00] about two years now, it'll be two years on November 2nd I've had less than half a dozen headaches from it again. So it seems to be working. But that area, what they didn't know, and there's not a lot of research on it, is that having surgery there, because all of your long term memories are right around your right temple, like a little bit behind.And that is where they cut into me and they had to do the surgery. So yeah, it was like, Hey, you're gonna have brain surgery, but you're also gonna have to remember all the fucking shit you ever went through. And yeah, that was, that was fun.De'Vannon: Are you glad that the [00:48:00] memories were released to the extent that you are able to work on processing through it, or would you have rather it stayed hidden?Jenn: It's like when people say that they're grateful for what they went through because it makes them who they are. Yeah, I agree with that, but I never wanted to go through all this shit, you know, like it's not like I wanted all of that to happen. So it's like a both, like I think if I didn't remember all of it, I would have been ignorance as bliss.But because I did go through all of it, I also found my voice to be able to advocate for others and that is more important to me. Yet it took me, realizing what I [00:49:00] went through to be able to find the strength to do it. Yet my ignorant is bliss side of me would've been totally fine, not realizing that my entire life.Yeah, it's like you, you know, I, I like the harder path I normally choose it. Not meaning to because I'm very stubborn, but, so it's a, it, it happened, De'Vannon: it worked out. I appreciate it. That's a positive perspective over. I encourage everyone to try their best to find something good out whatever it is that you went through.I agree with you in terms of my own history. Had there been another way, Lord, but it didn't go that way, so fuck it. Here we are. Let's move on. Hallelujah. To have and praise now since in staying better in adding to the problems that are already there. Yep. So you mentioned something that we're gonna pivot as we begin to wrap up here.Y'all, this bitch. Has probably the best [00:50:00] TikTok channel that I've ever like swed over, her outfit she has on the sequin and the glitter and the gl. It's just so powerful and it's so encouraging and it's so inspiring. And I mean, it's like, it's like, it's like on your TikTok channel you look like, so you like God extracted all of the pride spirit from every gay person in the world and just like put it in you and then you're the living manifestation of what it means to just be happy and acceptingAnd Jenn: so thank you. And I will say part of that was the person that was marketing and just being able to read what I wanted to do. Like she gave me the topic, but I was able to know how to make it happen. I, those videos are old because I haven't posted on TikTok or Instagram. The podcast is kind of on pause because I don't know how to do that myself.[00:51:00]Like if somebody says Jen, like it was, and I hate that I didn't know this, that it was National Indigenous Day recently. And I was like,Why did I not know that? Why did I not know that we changed laws from Columbus Day to be National Indigenous Day? Why are we not making it better known? And I also, you mention about how I post about Juneteenth and I am very proud of that post. Yet at the same time, I'm very disappointed in myself. That I didn't make a post for Hispanic Heritage Month or for Indigenous People's Day, but I also have to, even though I'm disappointed, I have to be able to say, Jen, you're one person.[00:52:00]You, you're only one person. Yes, I can make a difference. I also only have people have said spoons in the mental health area. I only have so much bandwidth. I only have so much that I can give. And if I half asked any any everything, people aren't gonna get what they deserve. And that's why I've put everything on pause.Now. If anybody wants to help me on social media, you are welcome into my life. I'm just gonna put that out there. Someone wants to come into my life and help on social media. That's, that's basically, I just need someone to be like, Jen, post this. Like, get the ideas outta my head and help me. I need somebody to hold my hand.But I, I appreciate where you were going with that. I just wanted to almost, it's almost like self deprecating where I'm like, I have to call myself out on that because I, I do still feel that disappointment in myself. De'Vannon: Well, [00:53:00] I mean, you already said it. You're only one person. I'll add to that, that you're, you cannot necessarily stand up for every group of people all the time, and perhaps it's not meant for you two.So whatever was meant to happen did happen. Wherever. Wasn't, didn't. And the beautiful thing about social media, podcasting, writing books, those things are ever green in the sense that even though those videos might be old, they can still have a positive influence on somebody today, which is one of the main reasons why we do what we do.Because, you know, social media work, podcasting is like a living testimony when we're dead and gone. People can still go back and find this. And it won't matter how old it is, what they're gonna be concerned about is, can I relate to this and can it help me? And what we are going through now is the same thing some people went through before.The same people, the same thing people are gonna go through after. So give yourself a break. Girlfriend, you doing the damn thing. And so thank you. And so shout out to Cardi B. [00:54:00] Yes. I love her. And so so she has an incredible, So I think, I think social media is great. I don't care. I don't think I even noticed that it was outdated because it was so captivating.It was so captivating. I was just so intrigued. And so one of, though, you were talking about like anxiety and depression and you mentioned just a few seconds ago about how you, everything was going great when you were searching for the job and everything, but you were still sad. A person who's super close to me in my life.Gets that way. Sometimes I get that way very, very rarely, and when I do, there's a scripture in the book of Psalms where David, I believe is talking and he's having one of those types of days and he's all like, Why are you cast down my soul and why are you quid within me? He was like, I'm sad. I don't know why I feel sad.Yeah. That's how I found it in the scripture. I know not everybody is [00:55:00] spiritual and scriptural, you know, like I am, but it really, really sparked with me when you mention that because sometimes our emotions betray our reality. Mm-hmm. , either way, a person can be manic and shit can just be like really terrible and they could be overly optimistic and I'm all like, No girl.This is serious. You need to calm down and deal with this shit. Then in the other hand, everything is great and yet they're sad with the blinds closed and under the covers, so. Jenn: It's, it's definitely something that I posted it becausefirst off, it fucking sucks anxiety attacks, depression being bipolar, type two being bipolar, like, mental health struggles are, are not talked about and accepted enough. And I, I do want to [00:56:00] mention that there, I, I wanna talk about my own struggles. Yes, I do also wanna call out that systemically there are marginalized communities that have to deal with mental health issues even more because of microaggressions and things that a white folk don't necessarily deal with.And I. I wanna call that out because that is something that many people won't acknowledge that they're going through something because they see it as racism from others. That that's the emotion that's coming up is because of that. I say that because anxiety and depression and anything that has changes our moods without our desire to [00:57:00] ptsd, we, they don't, they're not our front.They really, as we were talking earlier, really cause us to think things that are untrue. And it can be, yes, exercise and diet can help. Other people do have success with that. Some people don't. Some people need experimental drugs. Some people need prescribed drugs. Some people need therapy. Some people need journaling.Some people need kickboxing and boxing to be able to beat the shit outta something. It's different for all of us, and I want others to see that they're not alone going through it. Because I, I don't remember what I said in that post because I was crying. It was, it was fun but it was where we,[00:58:00]we don't expect it. So what do we do when it happens? How do we prepare ourselves if it happens? How do we have these conversations? If I am having a panic attack and. Van and I call you, what do you do? Like what are you supposed to do that that's not something that's taught in school. If I'm having a panic attack, like that's not something that if I'm becoming dis, having coping mechanisms that are unhealthy, such as self harm that friendships or family is taught to deal with, and this is really why I want to share these journeys because show that it happens before it may happen, but also be able to have people go, Oh shit, I went through that like a year ago.Maybe I should go look into getting help or [00:59:00] resources or builder tool belts. Because without it, we we're kind of just a hot fucking mess in the fact that this is when bad situations happen in my opinion. De'Vannon: Hey, I think your opinion is a golden opinion, and I encourage to listen to your opinion. I commend you on caring enough to make a Juneteenth video like you did.And she also has a, an ally video because Jen is a friend of the gays darling. Yes. The need, expect her to find her at any of your prides. You never know where she might end up next. So Jenn: it's true. I, well, I wanna go to all the prides. I really wanna go to Atlanta. That is where I hope I get to go next year.Like that would De'Vannon: be fun. You know what? Whenever you wanna plan it, you know, my boyfriend is from outside of Atlanta, and so I be in Atlanta like a lot. Yay. And then I just heard that they have an iowaska retreat thing outside of Atlanta, and so that's one of my next things to try for therapy. And [01:00:00] so yes, we can definitely plan in Atlanta Pride because their, their prides like happens in October.You know, they wait until not in June. Oh, yay. So and so so that was, you know, that pretty much wraps us up. I, I wanted to do this deeper, this deeper dive with you. I thank you for your transparency. The website is www dot shit, the number two talk about.com. She has a link tree also shit to talk about.And all of this will go in the show notes. The podcast is shit you don't want to talk about with the great hostess, as I, as I say in my Sian accent. And so my dear, there is anything you'd like to say to the world. Any last words? Closing comments, remarks, salutations, whatever. Go on. Jenn: I do. And that is beautiful.Humans. As shitty as it is, you'll get through this and you got this. It's not the end of the world, no [01:01:00] matter how much it seems. It is cause y'all. We're just a few of the people that can tell you that you can get through it. We've been through some shit, but it's also, you don't have to go through it.Like we said, there's other ways too.De'Vannon: All right. Thank you so much for coming on the show, my girl. You wrapped it up nicely. We'll see you next time. Thank you. Bye. Bye.Thank you all so much for taking time to listen to the Sex Drugs and Jesus podcast. It really means everything to me. Look, if you love the show, you can find more information and resources at SexDrugsAndJesus.com or wherever you listen to your podcast. Feel free to reach out to me directly at DeVannon@SexDrugsAndJesus.com and on Twitter and Facebook as [01:02:00] well.My name is De'Vannon, and it's been wonderful being your host today. And just remember that everything is gonna be right. 

Season 3, Episode 9By Any Other Name With The Reverend Robert W. LeeThe Reverend Robert Wright Lee, IV (Rob) is an author, activist, commentator, and preacher. His work has appeared on and in MTV, the View, The New Yorker, CNN, the New York Times, NPR, and countless other sources. As his name suggests, Rob is a descendant of Confederate General Robert E. Lee and has been engaged as an activist in the field of racial reconciliation.Find more about Rob and his work at https://linktr.ee/roblee4.Today's Good Egg: Do whatever you need to feel all right. Birthday Fundraiser Time! Reach out to sponsor the Worth Saving 'Gala' for $1,000, $3,000, or $5,000! Email Jay at Jay@JayShifman.com for more info.The Metro Philly 75 Power Women List: https://metrophiladelphia.com/power-lists/metro-philadelphia-power-women/As always, you can find everything you need, including our social media links, at our Campsite page: https://jay.campsite.bioLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSReach out and let us know who you are and that you're listening at JayShifman.com or ChooseYourStruggle.comOne Last Celtics Game With William (Jay's tribute to his late Stepfather-In Law)Jay's Podcast Reviews (for GreatPods!)Jay and our good friends Savage Sisters are both finalists for the Best of Philly awards! To vote for Jay (which you can once a day until September) go to metrophillysbest.com/voting and under Arts and Entertainment scroll down to Philly Blogger. To vote for Savage Sisters, go to the same link and under Services you'll find the Not For Profit category. Thanks!Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdosesLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSLooking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnerc ★ Support this podcast on Patreon ★

Season 3, Episode 8A Life of Advocacy with Larry D. MassLarry D. Mass has been an advocate for the gay community for his entire adult life. From working with Larry Kramer at Act Up to writing an article that's now recognized as the first report on what would eventually become the AIDS crises, Larry is a hero to the advocate community. He's also written about what it's like to be a gay Jew and interestingly his love of Richard Wagner. Learn more about Larry at https://lawrencedmass.com/. *** There were audio issues with this interview if you're wondering why it sounds so disjointed in moments. Birthday Fundraiser Time! Reach out to sponsor the Worth Saving 'Gala' for $1,000, $3,000, or $5,000! Email Jay at Jay@JayShifman.com for more info. The Metro Philly 75 Power Women List: https://metrophiladelphia.com/power-lists/metro-philadelphia-power-women/As always, you can find everything you need, including our social media links, at our Campsite page: https://jay.campsite.bioLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSReach out and let us know who you are and that you're listening at JayShifman.com or ChooseYourStruggle.comOne Last Celtics Game With William (Jay's tribute to his late Stepfather-In Law)Jay's Podcast Reviews (for GreatPods!)Jay and our good friends Savage Sisters are both finalists for the Best of Philly awards! To vote for Jay (which you can once a day until September) go to metrophillysbest.com/voting and under Arts and Entertainment scroll down to Philly Blogger. To vote for Savage Sisters, go to the same link and under Services you'll find the Not For Profit category. Thanks!Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdosesLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSToday's Good Egg: Support the birthday fundraiser and buy some merch!Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnerc ★ Support this podcast on Patreon ★

Season 3, Bonus EpisodeA Week Off Note From Your HostAs always, you can find everything you need, including our social media links, at our Campsite page: https://jay.campsite.bioLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSReach out and let us know who you are and that you're listening at JayShifman.com or ChooseYourStruggle.comOne Last Celtics Game With William (Jay's tribute to his late Stepfather-In Law)Jay's Podcast Reviews (for GreatPods!)The shows Google chose for their podcast creators program: https://medium.com/prxofficial/prx-welcomes-seven-podcast-teams-from-around-the-world-to-the-google-podcasts-creator-program-53db885c158Jay and our good friends Savage Sisters are both finalists for the Best of Philly awards! To vote for Jay (which you can once a day until September) go to metrophillysbest.com/voting and under Arts and Entertainment scroll down to Philly Blogger. To vote for Savage Sisters, go to the same link and under Services you'll find the Not For Profit category. Thanks!Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdosesLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSToday's Good Egg: No good egg or card this week.Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS ★ Support this podcast on Patreon ★

Season 3, Episode 7You've Got That (Desi) Spark In You! with Nehal Tenany and Annika SharmaLeave us a message for a chance to be played on the show and win a CYS schwag pack (and the first person this week will win a copy of YES! Magazine with Jay's article on drug use and pleasure: https://podinbox.com/CYSAnnika Sharma is a co-founder and co-host of That Desi Spark podcast, one of the largest independently run South Asian podcasts in the world, which has led to appearances on the BBC, Forbes, and on a Spotify billboard campaign. She currently lives in New York City and works as a health communications manager by day, while juggling her writing and podcasting careers by night. She is the author of the Chai Masala Club, a South Asian romcom series and the first novel, “Love, Chai, and Other Four-Letter Words,” was named an Amazon Editors' Pick while Annika was named a Writer to Watch by Apple. She is a lover of long conversations, superhero movies, reading, and travel, and can be found @annikasharma on Instagram, Twitter and Facebook.Nehal Tenany is a travel & lifestyle blogger, a podcaster, and content marketing manager at Silicon Valley tech startup, Gong. Nehal's love for content creation allowed her to start NehalTenany.com – an online destination for all things fashion, beauty, lifestyle, and travel. Nehal's growth on Instagram has allowed her to partner with incredible brands across the globe like Missguided, Lulus, MVMT, BondiBoost, Prose and more. Nehal's passion for her South Asian community helped her create her podcast, That Desi Spark,. Now one of the largest South Asian podcasts in the world, That Desi Spark has been featured in Forbes, Times of India, and most recently, Spotify Billboards. That Desi Spark podcast: https://www.thatdesispark.com/Jay and our good friends Savage Sisters are both finalists for the Best of Philly awards! To vote for Jay (which you can once a day until September) go to metrophillysbest.com/voting and under Arts and Entertainment scroll down to Philly Blogger. To vote for Savage Sisters, go to the same link and under Services you'll find the Not For Profit category. Thanks!Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdosesLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSToday's Good Egg: Write your elected officials to demand changes on gun policy. Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at our links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 3, Episode 6:From Prison to Policy Changemaker with Morgan GodvinMorgan Godvin is a student at the OHSU-PSU School of Public Health in Portland, where she was born and raised. She is a person in long-term recovery. As a harm reductionist, she performs syringe exchange, naloxone distribution, overdose prevention outreach, and infectious disease testing. In addition to her studies, she works as a freelance writer covering topics of drug policy and criminal justice. She received her Emergency Medical Technician certification from Portland Community College in 2012. While in active addiction she was arrested and jailed many times, eventually being sentenced to five years in federal prison. Her activism and advocacy now center around reducing the harms associated with drug use, preventing overdose death, and improving access to higher education in prison. She is a member of the Oregon Consortium for Higher Education in Prison.  She has been a consumer of harm reduction, treatment, and recovery services throughout the state. Her mother died of a prescription drug overdose in 2013 and she has lost many close friends to overdose. Merging lived experience with academic education and governmental action, she was confirmed to the Oregon Alcohol and Drug Policy Commission in February of 2020.For more from Morgan, check out her website (https://www.morgangodvin.com/) and her work at Filter (https://filtermag.org/author/morgan-godvin/amp/). Check out Beats Overdose at their site https://beatsoverdose.com/.Jay and our good friends Savage Sisters are both finalists for the Best of Philly awards! To vote for Jay (which you can once a day until September) go to metrophillysbest.com/voting and under Arts and Entertainment scroll down to Philly Blogger. To vote for Savage Sisters, go to the same link and under Services you'll find the Not For Profit category. Thanks!Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdosesLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSToday's Good Egg:  Do something to honor Pride Month. Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at our links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 3, Episode 5: Advocacy In Action With Garth MullinsToday's episode is a conversation with Garth Mullins! Garth is the Host and executive producer of the Crackdown Podcast. www.crackdownpod.com and an amazing drug use and user advocate. He's also a guy Jay really looks up to and an awesome musician.  For more on Garth:Crackdown Podcast Episode Resign: https://www.crackdownpod.com/episodes/episode-29-resignGarth's Music: https://soundcloud.com/garthmullinsJay and our good friends Savage Sisters are both finalists for the Best of Philly awards! To vote for Jay (which you can once a day until September) go to metrophillysbest.com/voting and under Arts and Entertainment scroll down to Philly Blogger. To vote for Savage Sisters, go to the same link and under Services you'll find the Not For Profit category. Thanks! Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdosesLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSToday's Good Egg:  Do... something.  Anything. Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at our links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 3, Episode 4: Rethinking Manliness Through Vulnerability with JT FrankJT Frank is a proud veteran and first responder. He started his career in the United States Air Force and has spent the last 23 years protecting and serving his country as a civilian federal employee. Through his extensive time in the military and as a first responder, he has become intimately familiar with both the positive and negative lifestyle and habits associated with these career fields. Unfortunately for JT, the negative habits progressively played a larger role in his life.  Through trial and error, JT realized, not only do these habits not serve him personally, they are detrimental to the long-term success and mental health of the veteran and first responder community.In 2019, JT came to crossroads in his life where, through personal reflection, he looked inwardly at what was holding him back from being the best possible version of himself. Through his exploration, JT realized the power of habit building, both negative and positive ones, in relation to happiness and success. He made major healthy lifestyle changes building better habits for himself, which have positively impacted his family, work and overall wellbeing.JT's lifestyle changes inspired him to create the Consequence of Habit podcast in 2020 with the overall goal of empowering individuals and communities by bringing awareness to the impact habits have on mental health, success and the environment. Since then, he has had the honor of interviewing a diverse range of guests from high-ranking military officers to professional athletes to your seemingly average everyday person. The common thread in all of JT's interviews is that his guests have made positive changes in their own lives by looking inwardly, examining their habits and making changes. JT has taken these lessons, pinpointed what worked, and incorporated them into something that benefits a broader audience.In late 2020, JT founded Consequence of Habit Inc, a 501(c)(3) charitable organization dedicated to helping others establish habits to succeed and improve mental health. JT accomplishes this by continually providing stories of hope, inspiration and positive change through the CoH podcast. JT also leads CoH experiential events, short volunteer hands-on teamwork and leadership experiences that facilitate connection, purpose and challenge.  What started as JT's personal journey has now become a passion to help others make positive changes in their own lives, the community, and the environment.Learn more at https://www.consequenceofhabit.org/ and https://www.consequenceofhabit.org/Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itJay recently wrote an article for YES! Magazine: https://www.yesmagazine.org/issue/pleasure/2022/05/18/drugs-better-policy-help-reduce-overdoses Leave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYSToday's Good Egg:  Do something for your neighborhood and your neighbors!Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at our links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 3, Episode 3: The Medical Side of Cannabis with Dr. Peter GrinspoonDr. Peter Grinspoon saw from an early age that the way our country handled cannabis wasn't build on science or fact. Through watching his brother die of cancer, go through med school and struggle with his own issue of Addiction, Dr. Grinspoon never lost his desire to see cannabis handled in a safer and more fact-based way. Now an advocate for increased access to medical cannabis, Dr. Grinspoon is one of the leading voices in the medical cannabis environment. Peter Grinspoon, M.D. is a primary care physician and cannabis specialist at Massachusetts General Hospital, an Instructor at Harvard Medical School and a certified Health and Wellness Coach. He is a Contributing Editor to Harvard Health Publications as well as a TEDx Speaker. He is the author of the memoir ‘Free Refills: A Doctor Confronts His Addiction'. He is a board member of the advocacy group Doctors For Cannabis Regulation. He is a former Associate Director of the Massachusetts Physician Health Service helping physicians with addiction and mental health issues.Learn more at https://www.petergrinspoon.com/. Choose Your Struggle Presents: Made It, Season 1, Stay Savage dropped April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itLeave us a message for a chance to be played on the show and win a CYS schwag pack: https://podinbox.com/CYS2 Lives (a special podcast rec in this episode)Today's Good Egg: Do something to contribute to the fight to save abortion access!  Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at our links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/. For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood. This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle. Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat. The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above. The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious. Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

For more info on other ideas around addiction, listen to these episodes of the Choose Your Struggle podcast: https://kite.link/DrNzingaHarrison, https://kite.link/DavidPoses, https://kite.link/IGNTD.Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

For more info on the MOVE bombing, see: https://www.npr.org/sections/codeswitch/2015/05/13/406243272/im-from-philly-30-years-later-im-still-trying-to-make-sense-of-the-move-bombing, https://www.inquirer.com/move-bombing/, and https://www.vox.com/the-highlight/2019/8/8/20747198/philadelphia-bombing-1985-move. Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/ and http://www.JayShifman.com.  A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.Special thanks to Quinn Greenhaus for her help with enhancing the sound quality of the show. To improve your podcast, check her out at https://www.quinngreenhaus.com/! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

Currently in production of Season 2, "Can You Survive - Charity Event" joins our podcaster, Kirk, to breakdown the latest episode of Survivor 41. What do the guys of CYS think of the latest season? They got the hot takes and can't wait to share them. Check out Can You Survive? Make sure to subscribe to our Youtube for live streamed podcasts! Follow Live Reality Games Network on Facebook | Instagram | Twitter linktr.ee/LiveRealityGames

Season 3, Episode 2: Living By The Book with Kristen MeinzerKristen got into podcasting early, over a decade ago, as a film critic for WNYC, a passion she still lives through her show Movie Therapy with Rafer & Kristen. But it was when she launched By The Book Pod in 2017 with Jolenta Greenberg, that she became a household name. Over the last five years, they've reviewed over 70 self help books, living, as the name suggests, by the book, for two weeks at a time. After their fiftieth book, they wrote a book of their own How To Be Fine, which you can get at CYS' Bookshop page. She's a regular contributor to Pop Culture Happy Hour on NPR and she also hosts The Royal Report. Kristen was named a 2020 Woman of the Year by The Women's Center in Washington DC and one of the 50 Most Influential Women in Podcasting by Quill in 2021. Her incredibly helpful book for people new to podcasting, So You Want to Start a Podcast, won the Audie Award for best business/personal development audiobook of 2020. As she hints on this show, there is more on the way too so stay tuned! For more from Kristen, visit her website at https://www.kristenmeinzer.com/ and for more on By the Book Pod visit https://bythebookpod.com/. Choose Your Struggle Presents: Made It, Season 1, Stay Savage drops April 29th! Subscribe to Made It's stream! https://kite.link/choose-your-struggle-presents-made-itLove Conquers Alz (a special podcast rec in this episode)Today's Good Egg: Subscribe to Made It! (PLEAAAAAAASE!!!)Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to me at Info@jayShifman.com. Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon!But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, baby onesies and much, much more!Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle.Support the Podcast, a different way: https://podhero.com/401017-ikv.Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at our links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

In this last preview to Season 3 of the Choose Your Struggle podcast, Jay chats with Adam al-Asad of Savage Sisters.Consider subscribing to Choose Your Struggle Presents: Made It, Season 1: Stay Savage https://kite.link/choose-your-struggle-presents-made-it to make sure you don't miss a single moment of our new show when it drops in a few weeks! Looking for someone to wow your audience now that the world is reopening? My speaking calendar is booking up fast! But if you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS★ Support this podcast on Patreon ★

This is the LAST preview for our new show, Choose Your Struggle Presents: Made It, Season 1: Stay Savage. Adam will announce at the end of our conversation when the season will drop!If you're hearing this on the Made It stream, check out our other podcast, Choose Your Struggle at https://kite.link/CYSSeason3!Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/. A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.  Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

And in today's episode, we are joined live from Singapore by the two founders of Straits Pens, Sunny and Lip, and they were kind enough to come on the show with us to discuss their Honest Inks line and the state of their Myu and Murex collections.Straits Pens - pens, Honest Inks and bespoke ink mixing.CYs tear downHero (Wingsung) 698Hero 8503776 Century Clarification from Lip Sing:In regards to the 4 new colours, I mentioned about Peranakan. They are actually also called Straits-born Chinese. They are basically Chinese that married the Malay women and have their own culture and food that is Malay influenced and have a very interesting culture. For the caucasian that married local women, they are known as Eurasians. 

Episode 13 – Neil Ditched Lucky 13 (ReLoaded after a Glitch played Episode 12 again. Thank you to our listeners for the catch)Is Scott going to have to talk to CYS? This episode starts off with Scott talking about his weekend escapades with his 8-year-old son and welding.  @Rustbusters @Rustys  #notsponsored More shenanigans from the production team as Davey “The Savage” Thompson finds a photo on Facebook and uses his photoshop skills to create a new photo of Jeff “The Italian Stallion” Chiaramonte.  Neil puts his 2nd Jeep in a ditch this winter. But wait, what happened to the guy who was there to rescue him? @RickHarper  Jeep: Trivia & Fun Facts Every Fan Should Know About The Great American Brand!   #notsponsored#notsponsored segment talks about Drive Shafts. Our Featured Brand is Adam's Drive Shafts.  Jeepardy Round 3 and Final Jeepardy. Can Scott continue his dominate lead or will Neil make a miraculous comeback? Thanks for listening and Jeep On!    

Made It is a member of the Shameless Podcast Network and a Choose Your Struggle production. Learn more at https://www.shamelessnetwork.com/ and at https://www.chooseyourstruggle.com/.Learn more about Sarah and Savage Sisters, including how to support, at https://savagesisters.org/.For more on Made It host Jay Shifman, see https://jay.campsite.bio/. A complete list of people you heard on this show (and those referenced but unheard from) and pictures to put a face with the names and voices can be found at https://drive.google.com/drive/folders/1-CIeh6f2bhgb3cGfJFCqvXL9SJWvSUtN?usp=sharing.Made It Season 1: Stay Savage was recorded in South Philadelphia, except for the interview with Mother Mary Nolan, which was recorded at her house in the Philly suburbs, and the audio you hear in Episode 1, which was recorded on site in North Philly's Kensington neighborhood.This show is dedicated to: Jim, David, Lauren, Renae, and the roughly 80,000 people who lost their life to OD in this country during the period of time in which the show was being made. Made It was created without any sponsorship dollars. The partners you hear from were all donated their spots free of charge. But before you discount them for it know that we are so thankful for their support at a time when that was hard to find! And it means they are all orgs. and people we LOVE. So check them out! And to support us, reach out at info@jayShifman.com or through www.chooseyourstruggle.com or subscribe to our Patreon at https://www.patreon.com/ChooseYourStruggle.Buy some merch (including the official Season 1: Stay Savage design!) at our store! Our partners for this show are as follows:Drug Policy AllianceGreat PodsYaFavTrashmanOf Substancee3 Radio/The QubeThe People of Color Psychedelic CollectiveConsequence of HabitThe Head and the HandThe New Books NetworkOotifyThe podcasts profiled on this show are brought to you by Great Pods and include:I'm The VillainGhost TownWhat's On Your Mind with Jani RadCookies for BreakfastBased on a True StorySalad with a Side of FriesSex, Drugs, and JesusHotter Than HealthCovering All Aspects of Holistic Health with Amanda LoveCrackdownDon't like something you heard on the show? That's fine! This is a tough subject. Reach out at info@jayshifman.com and let's chat.The theme song for this show was created by me using the song All That by Bensound. For proof of license please see the certificate in the compendium linked above.The Made It theme, heard in Episode 10, was composed and performed by Leduce and Rob Devious.  Looking for someone to wow your audience now that the world is reopening? My speaking calendar is open! If you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out at Info@JayShifman.com.  · Tank Tops are in! You can see what they look like on the website (thanks to Jay's wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! · But that's not all! You can now buy even more merch! Check out our store on Teepublic at https://www.teepublic.com/stores/choose-your-struggle?ref_id=24308 for shirts, mugs, stickers, phone cases, and much, much more! · Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle · Leave us an audio message to share feedback and have a chance to be played on the show: https://podinbox.com/CYS · Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. · Support the Podcast, a different way: https://podhero.com/401017-ikv. · Our Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS · Our Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS

In honor of Military Family Appreciation Month, this episode brings you an overview of the services available to military families. From childcare to a liaison to assist with the challenges of transferring to a new school, CYS has resources to smooth the process.

Today, in Part 2 of this Everything Belongs Podcast episode, Madison is in her second half of her conversation with Matthew Krepps. Matthew is Co-founder of Circle Yoga Shala, is a C-IAYT, E-500RYT, Ayurvedic Chef,  Movement Expert and creator of the online program The Wisdom Enneagram. Circle Yoga Shala is a Wisdom School for Yoga, Creative Movement, and Self-Inquiry located in Arkansas' Ozark Mountains. Matt has been a practitioner of Yoga and Ayurveda, Yoga's sister science, for close to three decades. He owned and operated a premier yoga studio for ten years before founding Circle Yoga Shala in 2009. Matt developed the CYS yoga teacher training programs (200hr and 500hr) and an internationally accredited 1,000-hour Yoga Therapy program, all of which surpass marketplace standards. Matt began studying the wisdom of the Enneagram 16 years ago, from fixation and beyond. He leads Self-Observation groups and Work Circles, where the Enneagram is utilized to discover what gets in the way of an integrated, fulfilling life. In this episode, Madison and Matthew continue their ongoing conversation on the Enneagram. In this second episode, the conversation becomes even more nuanced, discussing the differences of each type, fixation and motivation of the subtypes, mistyping ourselves, how important it is to be doing this work with mentors and community and so much more depth into diversity, the Enneagram process, understanding the ego and freedom, along with so much more!This conversation is a deep dive into the full intent and wisdom of the Enneagram, like you may never have heard about it before. If you haven't listened to part 1, we encourage you to go listen to that episode first and return here for part 2, then join the waitlist for Matt and Holly's Enneagram Course here: https://www.circleyogashala.com/enneagram-course. Listen in and find the full show notes here: http://madisonmorrigan.com/podcast-rss-feed/69 Guest LinksLearn more about the Circle Yoga Shala and Matthew's Podcast: https://www.circleyogashala.com/Learn more about the Enneagram Course offered at the Circle Yoga Shala: https://www.circleyogashala.com/enneagram-courseListen to the Lost Ways of Knowing Podcast: https://lost-ways-of-knowing.simplecast.com/ 

Today, in Part 1 of this Everything Belongs Podcast episode, Madison is in conversation with Matthew Krepps. Matthew is Co-founder of Circle Yoga Shala, is a C-IAYT, E-500RYT, Ayurvedic Chef and Movement Expert. Circle Yoga Shala is a Wisdom School for Yoga, Creative Movement, and Self-Inquiry located in Arkansas' Ozark Mountains. Matt has been a practitioner of Yoga and Ayurveda, Yoga's sister science, for close to three decades. He owned and operated a premier yoga studio for ten years before founding Circle Yoga Shala in 2009. Matt developed the CYS yoga teacher training programs (200hr and 500hr) and an internationally accredited 1,000-hour Yoga Therapy program, all of which surpass marketplace standards. Matt began studying the wisdom of the Enneagram 16 years ago, from fixation and beyond. He leads Self-Observation groups and Work Circles, where the Enneagram is utilized to discover what gets in the way of an integrated, fulfilling life. In this episode, Madison and Matthew speak on Enneagram identification as a spiritual, integrative and long term process and why your "type" is not, in fact, your True Essence. This conversation is a deep dive into the full intent and wisdom of the Enneagram, like you may never have heard about it before. Listen in here and stay tuned next week for part 2….Listen in and find the full show notes here: http://madisonmorrigan.com/podcast-rss-feed/67Guest LinksLearn more about the Circle Yoga Shala and Matthew's Podcast: https://www.circleyogashala.com/Learn more about the Enneagram Course offered at the Circle Yoga Shala here: https://www.circleyogashala.com/enneagram-course

Tired of Begging Your Chapter to Invite?Cys Bronner, BNI Executive Director is here to say “Stop Yelling, Start Growing”. By focusing on what's working and using the tools at hand, your membership will naturally increase in happiness and members, creating more referrals for everyone. Transcript: Stop Yelling, Start GrowingHi, I'm Cys Bronner, Executive Director of BNI4Success in the Greater Los Angeles area and earlier this week I was remembering something BNI Executive Director Patti Salvucci once said “Chapters under 20 drive me crazy, because they don't know how great they are. If they knew how great there are, they would be telling everyone!”   I think understanding how great we are is more important than anything we do towards inviting potential members into the group. Instead of yelling, “Ya gotta invite, ya gotta invite!” we need to both become and acknowledge that the chapter is great.  So how do we get great?   That's the question isn't it? It's easy to answer when you understand the tools at hand. But understanding the tools – which are a variety of reports – isn't the activity; it's the measurement of your activities. OMG, Cys – you are confusing us!  Our real goal is to build a healthy chapter – one that is strong from the ground up, with every member working together towards each other's success. Once you have that, you have the culture of knowing how great you are and wanting to share that. “Individual commitment to a group effort – that is what makes a team work, a company work, a society work, a civilization work.”  Vince LombardiWhen you talk about the individuals creating a group effort, you really need an overview to see how and where that is happening  Reports I like to work with: ·      Chapter Traffic Lights·      Power of One Report·      (and of course) PALMS·      Sponsor ReportMy favorite overview to start with is our chapter traffic lights. It's just one of our tools that highlights the group's benchmarks giving you a snap shot of what is working.  Too many chapters think that it is a report to show where they rank among other chapters and don't really pay attention to how they got to where they are placed in the report.   Every chapter has the ability to sit in the green at 100 points (actually you can get there at 80 points) so what does it take?   Let's look at the categories – they are very similar to our members Power of One report – we have:·      Chapter Size ·      Chapter Growth·      Retention ·      Referrals·      Visitors ·      Conversion ·      Absenteeism What's Working?  What I look for first is the areas where the chapter is excelling; in other words what's working.   This isn't just about letting a chapter know where they are succeeding, but it's also a step towards chapter growth. Once you know what's working and then move towards the next thing that is doing well or on an upwards climb, other areas seem to naturally shift into place. Think about it, if you're hitting all your benchmarks, you are definitely firing on all cylinders and you'll have a larger, stronger chapter for it.   Where it can be deceptive is your retention, and this can trip some chapters up. On occasion I see chapters that are so worried about their chapter size, that they pass on empowering the Membership Committee to be good gardeners – nurturing and pruning as they go along – cre

The CYS returns with a great conversation featuring Adonica Duggan. Adonica runs the Baton Rouge Alliance For Students. She has many thoughts on the state of education in the Capital Region.

Season 2, Episode 57!NORML and the Parent Movement, Weed's Long, Strange Trip to Just Say NoThis week's guest is Emily Dufton! Emily is an incredible researcher who is probably best known for her book Grass Roots: The Rise and Fall and Rise of Marijuana in America. Jay reads a lot of drug policy and history books and says this one is in his top 5. You can find it at the Bookshop link: https://bookshop.org/shop/CYS and stay up to date on all of Emily's work at her twitter: https://twitter.com/emily_dufton. The first person who reaches out (either through the website or social media) will get Emily's book sent to them FOR FREE! All you have to do is let Jay know you listened to this episode and give him your address. That's it! Anyone else who reaches out will get a sticker sent to them. *** Editor's note: the first 9 seconds of the interview, where Emily introduces herself, got cut off in editing for some reason. It was added back in post production hence why it sounds different than the rest of the show. ***Today's Good Egg: Reach out to someone who is not your political persuasion. Thank you to Devannon Hubert of the Sex Drugs and Jesus podcast for his review of the show!Positive Mental Health Playlist: https://open.spotify.com/playlist/4aT2U6PZ3MUWcesxQrAbi1Looking for someone to wow your audience now that the world is reopening? My speaking calendar is booking up fast! But if you're interested in bringing me to your campus, your community group, your organization or any other location to speak about Mental Health, Substance Misuse & Recovery, or Drug Use & Policy, reach out to my strategist Ryan Holzhauer at ryan@jayshifman.com. Tank Tops are in! You can see what they look like on the website (thanks to my wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. Support the Podcast, a different way: https://podhero.com/401017-ikv. Learn more about the Shameless Podcast Network: https://www.shamelessnetwork.com/ My Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS My Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS As always, you can find more at my links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 2, Episode 40Monday Motivation: A Conversation Around Cannabis Policy and Thinking With Kyle Blanks Pt. 2What you're hearing today is the second half of I conversation I recorded with Road Runner CBD (and the Corner of the Clubhouse Podcast on the Shameless Podcast Network)'s own Kyle Blanks. You probably remember Kyle from earlier this season. Well, he's an excellent resource on Cannabis and now a podcaster himself so we're doing a series on Cannabis! This Monday and last Monday are the first convo, around policy and thinking. Other topics will come in the future. You can learn more about Kyle's work at Road Runner CBD (which is also one of my partners).What do you think? Everyone who responds, either by social media or my website, will get a sticker mailed to them. The first person to respond each week will get a magnet! So reach out or post something on your personal social media and tag me (and maybe share the show in the process?)!If something in this episode upsets you, or makes you feel a certain way, take a moment and do some mindfulness. When you have the words, the thought thrashed out, send it to me! Share the podcast, tell the world your thoughts. That's how we make change.The first give away of this season is live! You have to like/connect/follow CYS on the big six social media (Twitter, Facebook, LinkedIn, Instagram, YouTube, and Tik Tok) and message me on one of those platforms to enter. If you don't have one, that's ok. Tell me that when you message me. You can find the links at the campsite bio below (it's the last link in the show notes) or searching Jay Shifman/ Choose Your Struggle on social media. Reach out through any social media site or my website for details or with questions.The winner of this giveaway with get a Road Runner product on the house! Any of them you want, it's on me. So enter today!No Good Egg or Card on Monday episodes. Love being a part of the community and want to show it off? Grab a Choose Your Struggle Tank Top, sticker, and magnet! You can see what they look like on the website (thanks to my wife for modeling the women's cut of the tank top). Reach out through the website to order. Patreon supporters get a discount so join Patreon! Support the Podcast: https://www.patreon.com/ChooseYourStruggle Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. Support the Podcast, a different way: https://podhero.com/401017-ikv. My Sponsor Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS My Sponsor Mountain Made: https://mountainmadecbd.com/ My Sponsor Four Sigmatic (10% off with Code Choose Your Struggle) My Sponsor FIVRR: https://track.fiverr.com/visit/?brand=fiverrcpa&bta=182301 My Sponsor Fanatics: https://fanatics.ncw6.net/CYS As always, you can find more at my links: https://jay.campsite.bio/ ★ Support this podcast on Patreon ★

Season 2, Episode 39!Breaking The Taboo Of Talking About Suicide With Serena Hope SunOn this week's episode of the Choose Your Struggle podcast, Jay chats with Serena Hope Sun! Besides being an actress, Serena is the founder of Breaking Taboo, an organization seeking to change the way we talk about Suicide. Besides working on a documentary, Breaking Taboo is constantly working to help people have conversations around this important topic. You can find more at their website: https://breaking-taboo.org/. Today's Good Egg: Reach out to someone you care about and check in! New sponsor alert! Road Runner and CYS are joining forces. Check the link below and use the code CYS to get 10% off your CBD needs.The first give away of this season is live! You have to like/connect/follow CYS on the big six social media (Twitter, Facebook, LinkedIn, Instagram, YouTube, and Tik Tok) and message me on one of those platforms to enter. If you don't have one, that's ok. Tell me that when you message me. You can find the links at the campsite bio below (it's the last link in the show notes) or searching Jay Shifman/ Choose Your Struggle on social media. Reach out through any social media site or my website for details or with questions.The winner of this giveaway with get a Road Runner product on the house! Any of them you want, it's on me. So enter today! Tank Tops are in! You can see what they look like on the website (thanks to my wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. Support the Podcast, a different way: https://podhero.com/401017-ikv. My Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS My Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS My Sponsor FIVRR: https://track.fiverr.com/visit/?brand=fiverrcpa&bta=182301 As always, you can find more at my links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 2, Episode 38Monday Motivation: A Conversation Around Cannabis Policy and Thinking With Kyle Blanks Pt. 1What you're hearing today is the first half of I conversation I recorded with Road Runner CBD (and the Corner of the Clubhouse Podcast on the Shameless Podcast Network)'s own Kyle Blanks. You probably remember Kyle from earlier this season. Well, he's an excellent resource on Cannabis and now a podcaster himself so we're doing a series on Cannabis! This Monday and next Monday are the first convo, around policy and thinking. Other topics will come in the future. You can learn more about Kyle's work at Road Runner CBD (which is also one of my partners). What do you think? Everyone who responds, either by social media or my website, will get a sticker mailed to them. The first person to respond each week will get a magnet! So reach out or post something on your personal social media and tag me (and maybe share the show in the process?)!If something in this episode upsets you, or makes you feel a certain way, take a moment and do some mindfulness. When you have the words, the thought thrashed out, send it to me! Share the podcast, tell the world your thoughts. That's how we make change.The first give away of this season is live! You have to like/connect/follow CYS on the big six social media (Twitter, Facebook, LinkedIn, Instagram, YouTube, and Tik Tok) and message me on one of those platforms to enter. If you don't have one, that's ok. Tell me that when you message me. You can find the links at the campsite bio below (it's the last link in the show notes) or searching Jay Shifman/ Choose Your Struggle on social media. Reach out through any social media site or my website for details or with questions.The winner of this giveaway with get a Road Runner product on the house! Any of them you want, it's on me. So enter today!No Good Egg or Card on Monday episodes. Love being a part of the community and want to show it off? Grab a Choose Your Struggle Tank Top, sticker, and magnet! You can see what they look like on the website (thanks to my wife for modeling the women's cut of the tank top). Reach out through the website to order. Patreon supporters get a discount so join Patreon! Support the Podcast: https://www.patreon.com/ChooseYourStruggle Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. Support the Podcast, a different way: https://podhero.com/401017-ikv. My Sponsor Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS My Sponsor Mountain Made: https://mountainmadecbd.com/ My Sponsor Four Sigmatic (10% off with Code Choose Your Struggle) My Sponsor FIVRR: https://track.fiverr.com/visit/?brand=fiverrcpa&bta=182301 My Sponsor Fanatics: https://fanatics.ncw6.net/CYS As always, you can find more at my links: https://jay.campsite.bio/ ★ Support this podcast on Patreon ★

Season 2, Episode 37!Spreading Love After Unimaginable Tragedy with Chris SingletonOn this week's episode of the Choose Your Struggle podcast, Jay chats with speaker and author Chris Singleton! After losing his mother in the racist shooting at Mother Emanuel Church, an event Chris describes as unimaginable, Chris spent a few years playing minor league baseball before turning his attention to his mission of spreading love and creating unity. Chris is the author of the incredible children's book (grab it at my bookshop link: https://bookshop.org/shop/CYS) and is one of the most popular inspirational speakers on the market. Learn more about Chris at: https://www.chrissingleton.com/Today's Good Egg: Have a positive moment, a positive interaction, with someone who doesn't look like you.  New sponsor alert! Road Runner and CYS are joining forces. Check the link below and use the code CYS to get 10% off your CBD needs.The first give away of this season is live! You have to like/connect/follow CYS on the big six social media (Twitter, Facebook, LinkedIn, Instagram, YouTube, and Tik Tok) and message me on one of those platforms to enter. If you don't have one, that's ok. Tell me that when you message me. You can find the links at the campsite bio below (it's the last link in the show notes) or searching Jay Shifman/ Choose Your Struggle on social media. Reach out through any social media site or my website for details or with questions.The winner of this giveaway with get a Road Runner product on the house! Any of them you want, it's on me. So enter today! Tank Tops are in! You can see what they look like on the website (thanks to my wife for modeling the women's cut). Reach out through the website to order. If you're looking for something a little less expensive, magnets are in too! Check them out on the website or Instagram. Patreon supporters get a discount so join Patreon! Support the Podcast on Patreon: https://www.patreon.com/ChooseYourStruggle Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. Support the Podcast, a different way: https://podhero.com/401017-ikv. My Partner Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS My Partner Road Runner (Use Code CYS for 10% off): www.roadrunnercbd.com/ref/CYS My Sponsor FIVRR: https://track.fiverr.com/visit/?brand=fiverrcpa&bta=182301 As always, you can find more at my links: https://jay.campsite.bio ★ Support this podcast on Patreon ★

Season 2, Episode 36Monday Motivation: This week we're talking about racial disparities in the cannabis market. This one is tough because overall a strong cannabis market is a positive thing of course. But the direction it's heading in, mirroring the disparity in our capitalistic society, is troubling. So what can we do?  100+ Black Owned Cannabis Businesses To Support Right NowWhat do you think? Everyone who responds, either by social media or my website, will get a sticker mailed to them. The first person to respond each week will get a magnet! So reach out or post something on your personal social media and tag me (and maybe share the show in the process?)!If something in this episode upsets you, or makes you feel a certain way, take a moment and do some mindfulness. When you have the words, the thought thrashed out, send it to me! Share the podcast, tell the world your thoughts. That's how we make change.The first give away of this season is live! You have to like/connect/follow CYS on the big six social media (Twitter, Facebook, LinkedIn, Instagram, YouTube, and Tik Tok) and message me on one of those platforms to enter. If you don't have one, that's ok. Tell me that when you message me. You can find the links at the campsite bio below (it's the last link in the show notes) or searching Jay Shifman/ Choose Your Struggle on social media. Reach out through any social media site or my website for details or with questions.The winner of this giveaway with get a Road Runner product on the house! Any of them you want, it's on me. So enter today!No Good Egg or Card on Monday episodes. Love being a part of the community and want to show it off? Grab a Choose Your Struggle Tank Top, sticker, and magnet! You can see what they look like on the website (thanks to my wife for modeling the women's cut of the tank top). Reach out through the website to order. Patreon supporters get a discount so join Patreon! Support the Podcast: https://www.patreon.com/ChooseYourStruggle Review the Podcast: https://ReviewThisPodcast.com/Choose-Your-Struggle. Support the Podcast, a different way: https://podhero.com/401017-ikv. My Sponsor Bookshop (Support Local Book Stores and the Podcast in the Process!): https://bookshop.org/shop/CYS My Sponsor Mountain Made: https://mountainmadecbd.com/ My Sponsor Four Sigmatic (10% off with Code Choose Your Struggle) My Sponsor FIVRR: https://track.fiverr.com/visit/?brand=fiverrcpa&bta=182301 My Sponsor Fanatics: https://fanatics.ncw6.net/CYS As always, you can find more at my links: https://jay.campsite.bio/ ★ Support this podcast on Patreon ★

This is the story of Victim #1, Aaron Fisher. Aaron Fisher had a very difficult childhood filled with abuse. He never knew his paternal father and the stepfather he endured for five years abused his mother and half sister and eventually went to prison after pleading guilty to over 100 counts of abuse Fisher's mother Dawn Daniels loved to drink and party. Dawn knew all about "making rain" from an abuse case. It was a complaint made by Dawn that started this entire mess. Was Dawn afraid for her son or was she shopping for a big payday? She told her neighbor, Josh Fravel, that she was gonna "own that MF's house" Aaron was a well-known storyteller. His school administrators didn't believe he was abused by Sandusky, his friends didn't believe he was abused by Sandusky either but a young CYS caseworker did and she brought him to therapist Mike Gillum. Gillum spent months helping Aaron "remember" his abuse and prepping him to give grand jury testimony. Aaron made a terrible witness, so poor a witness that prosecutors enlisted the help of a naïve cub reporter to keep their case alive. And then they got lucky... via Knit

Retrouvez l'interview de François Cys pour l'installation sonore Espaces Cyclophones. 

2021-04-21 - SNKronize Ep. 015: SNK Podcast w/ @jchensor, @OlafRedland, & @KittyKaboooom This week, it's pretty obvious from the get-go that we are gonna get Chris to complete CYS based on the silhouette. But how is he gonna look after the expectations set by how well Yashiro and Shermie looked? Also, Olaf finally takes the time to present the Blue Mary dissertation on why KOF XIV feels to have betrayed the *true* essence of Blue Mary! For the community content creator of the week, we fittingly highlight "@Ichika_0908", a cosplayer with a similar passion for Blue Mary and other SNK franchises. We show off how well she embodies Blue Mary and definitely have a soft spot for her suplexes! Twitter: https://twitter.com/ichika_0908 - SNKronize Episode Links - YOUTUBE LINK: https://www.youtube.com/watch?v=uIlSpOc56cs SOUNDCLOUD LINK: https://www.soundcloud.com/snkronize015 SPOTIFY LINK: http://tinyurl.com/UCTVSpotify - Hosts Social - OlafRedland: twitter.com/OlafRedland KittyKaboooom: twitter.com/KittyKaboooom - The Chensor Dynasty - Please follow and consider subscribing to The Chensor Dynasty stream on Twitch: twitch.tv/jchensor Support and Follow James On Other Social Media Platforms: Patreon: patreon.com/jchensor Twitter: twitter.com/jchensor And join The Chensor Dynasty Discord! https://discord.gg/2RVPc9C A friendly FGC environment designed to be welcoming to newcomers and beginners and those that want to have a positive atmosphere to discuss their favorite hobby of Fighting Games! - UltraChenTV - Please consider also supporting the UltraChenTV Patreon! http://patreon.com/ultrachentv Twitch stream - http://twitch.tv/ultrachentv Twitter - http://twitter.com/ultrachentv UltraDavid - http://twitter.com/ultradavid

In this episode, the Garrison Commander and the Fort Belvoir School Liaison, Jaimie Albers, and the CYS Program Operations Specialist, Jessica Terrell, talk about programs and issues related to military children in observance of #MonthoftheMilitaryChild.

Part Two of the conversation continues... Grab some coffee and join Mary, Audrey, Jimmy Hinton as we talk more about Testing vs. Grooming, educating church leaders, and CYS and the foster system.

This episode we chat with Francisco Jamison, CYS Director, and Kathleen Wyrough and we talk about some big news for CYS here at Fort Meade. As always we also have our Jibber segment from you friendly neighborhood PAO Chad Jones. Tune in!

Danny Kemp and I talk about our picks for gold gloves, MOY, ROY, CYs and MVPs.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.06.326603v1?rss=1 Authors: Patra, S., Lin, C.-W., Ghosh, M. K., Havens, S. M., Cory, S. A., Russell, D. H., Barondeau, D. P. Abstract: Iron-sulfur (Fe-S) clusters have a key role in many biochemical processes and are essential for most life forms. Despite recent mechanistic advances in understanding the Fe-S cluster biosynthetic pathway, critical questions remain unresolved. Although human NFS1 and E. coli IscS share ~60% sequence identity, NFS1 exhibits low activity and requires activation by the Friedreich's ataxia protein frataxin (FXN) for in vivo function. Surprisingly, structures of the human complex reveal three distinct quaternary structures with one form exhibiting the same subunit interactions as IscS. An architectural switch model has been proposed in which evolutionarily lost interactions between NFS1 subunits results in the formation of low-activity architectures; FXN binding compensates for these lost interactions and facilitates a subunit rearrangement to activate the complex. Here, we used a structure and evolution-guided approach to identify three conserved residues proposed to weaken interactions between NFS1 subunits and transplanted these amino acids into IscS. Compared to native IscS, the engineered variant had a 4000-fold weaker dimer interface and diminished activity that correlated with the absence of the second catalytic subunit. Remarkably, the addition of the FXN homolog to the engineered variant stimulated the decay of the Cys-quinonoid pyridoxal 5'-phosphate intermediate, shifted IscS from the monomeric to dimeric form, and increased the cysteine desulfurase activity, reproducing results from the human system and supporting the architectural switch model. Overall, these studies indicate a weakening of the homodimeric interface was a key development during the evolution of the eukaryotic system and provide new insights into the role of FXN. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.28.316307v1?rss=1 Authors: Jin, F., Wang, Y., Wang, M., Sun, M., Hattori, M. Abstract: Membrane proteins play numerous physiological roles and are thus of tremendous interest in pharmacology. Nevertheless, stable and homogeneous sample preparation is one of the bottlenecks in biophysical and pharmacological studies of membrane proteins because membrane proteins are typically unstable and poorly expressed. To overcome such obstacles, GFP fusion-based Fluorescence-detection Size-Exclusion Chromatography (FSEC) has been widely employed for membrane protein expression screening for over a decade. However, fused GFP itself may occasionally affect the expression and/or stability of the targeted membrane protein, leading to both false-positive and false-negative results in expression screening. Furthermore, GFP fusion technology is not well suited for some membrane proteins depending on their membrane topology. Here, we developed an FSEC assay utilizing nanobody (Nb) technology, named FSEC-Nb, in which targeted membrane proteins are fused to a small peptide tag and recombinantly expressed. The whole-cell extracts are solubilized, mixed with anti-peptide Nb fused to GFP and applied to a size-exclusion chromatography column attached to a fluorescence detector for FSEC analysis. FSEC-Nb enables one to evaluate the expression, monodispersity and thermostability of membrane proteins without the need of purification by utilizing the benefits of the GFP fusion-based FSEC method, but does not require direct GFP fusion to targeted proteins. We applied FSEC-Nb to screen zinc-activated ion channel (ZAC) family proteins in the Cys-loop superfamily and membrane proteins from SARS-CoV-2 as examples of the practical application of FSEC-Nb. We successfully identified a ZAC ortholog with high monodispersity but moderate expression levels that could not be identified with the previously developed GFP fusion-free FSEC method. Consistent with the results of FSEC-Nb screening, the purified ZAC ortholog showed monodispersed particles by both negative staining EM and cryo-EM. Furthermore, we identified two membrane proteins from SARS-CoV-2 with high monodispersity and expression level by FSEC-Nb, which may facilitate structural and functional studies of SARS-CoV-2. Overall, our results show FSEC-Nb as a powerful tool for membrane protein expression screening that can provide further opportunity to prepare well-behaved membrane proteins for structural and functional studies. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.17.301382v1?rss=1 Authors: Morud, J., Hardege, I., Liu, H., Wu, T., Basu, S., Zhang, Y., Schafer, W. Abstract: Pentameric ligand-gated ion channels (LGCs) play conserved, critical roles in fast synaptic transmission, and changes in LGC expression and localisation are thought to underlie many forms of learning and memory. The C. elegans genome encodes a large number of LGCs without a known ligand or function. Here, we deorphanize five members of a family of Cys-loop LGCs by characterizing their diverse functional properties that are activated by biogenic amine neurotransmitters. To analyse the neuronal function of these LGCs, we show that a novel serotonin-gated cation channel, LGC-50, is essential for aversive olfactory learning. lgc-50 mutants show a specific defect in learned olfactory avoidance of pathogenic bacteria, a process known to depend on serotonergic neurotransmission. Remarkably, the expression of LGC-50 in neuronal processes is enhanced by olfactory conditioning; thus, the regulated expression of these receptors at synapses appears to represent a molecular cornerstone of the learning mechanism. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.25.266015v1?rss=1 Authors: Chavalwan, T., Hasan, F. A. H., Cheesman, P., Yusuf, R., Draheim, R. R. Abstract: The Escherichia coli sensor kinase EnvZ modulates porin expression in response to various stimuli including intracellular osmolarity, intracellular pH and periplasmic interaction with MzrA. The expression of two major outer membrane porins, OmpF and OmpC, are regulated by EnvZ, and act as passive diffusion-limited pores allowing compounds, including certain classes of antibiotics such as {beta}-lactams and fluoroquinolones, to enter the bacterial cell. Even though allosteric processing occurs within both the periplasmic and cytoplasmic domains of EnvZ, how the transmembrane domain bi-directionally transmits these signals remains not fully understood. Here, we employ a library of single-Cys-containing EnvZ proteins to perform scan-SCAM in order to map the precise residue composition of TM1. Our results demonstrate that residue positions 19 through 30 reside within the membrane core and compose a tightly packed portion of TM1. We also show that positions 15 through 18 and position 31 are interfacial and slightly splayed apart compared to those tightly packed within the hydrophobic core. Finally, we reveal that residue positions 33 and 34 reside in the periplasm and participate in robust protein-protein interactions, while the periplasmic positions 35 through 41 exhibit helical periodicity. We conclude by synthesizing these new insights with recent high-resolution structural information into a model of membrane-spanning allosteric coupling between the periplasmic and cytoplasmic domains of EnvZ. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.21.260521v1?rss=1 Authors: Qiu, Y., Liu, J., Li, Y., Xue, Y., WANG, H., Liu, W. Abstract: 2-Aminovinyl-cysteine (AviCys) is an unusual thioether amino acid shared by a variety of ribosomally synthesized and posttranslationally modified peptides (RiPPs), as part of a macrocyclic ring system that contains the C-terminal 4 or 6 residues of a precursor peptide. This amino acid is nonproteinogenic and arises from processing the C-terminal Cys residue and an internal Ser/Thr residue to form an unsaturated thioether linkage. Enzyme activities for forming lanthionine (Lan), a distinct saturated thioether residue characteristic of lanthipeptide-related RiPPs, has long been speculated to be necessary for AviCys formation. Based on investigations into the biosynthesis of thioviridamide non-lanthipeptdes in Streptomyces sp. NRRL S-87, we here report an alternative path for AviCys formation that is independent of known Lan synthetase activity. This path relies on four dedicated enzymes for posttranslational modifications of the precursor peptide, in which TvaES-87, a phosphotransferase homolog, plays a critical role. It works with LanD-like flavoprotein TvaFS-87 to form a minimum AviCys synthetase complex that follows the combined activity of TvaCDS-87 for Thr dehydration and catalyzes Cys oxidative decarboxylation and subsequent Michael addition of the resulting enethiol nucleophile onto the newly formed dehydrobutyrine residue for cyclization. With TvaES-87, TvaFS-87 activity for Cys processing can be coordinated with TvaCDS-87 activity for minimizing competitive or unexpected spontaneous reactions and forming AviCys effectively. Copy rights belong to original authors. Visit the link for more info

Thanks for coming along on the CYS journey! Welcome to episode 23! Stick around after the interview for today's Choose Your Card and Good Egg. To learn more about Greg, find him at his website: https://www.gregnance.org/, or his Instagram:https://www.instagram.com/gregrunsfar/. Pat's Shout Out request is you check out the Cookies for Breakfast Podcast, which you can find here: https://open.spotify.com/show/1UZpUBLoetXL3nNtUTOrVz. For today's Good Egg: https://leavingthevalley.com/. Hoody Time new video, Truth: https://www.youtube.com/watch?v=50zceF8ECZI Sarah Korenblit's podcast: https://www.buzzsprout.com/1210457 As always, you can find more info on me, and Choose Your Struggle, at my links: https://jay.campsite.bio/. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/jay-shifman/message

When it comes to awards in Major League Baseball, there are two big ones. For position players, it's the MVP. For pitchers, its the Cy Young Award. Once in a while someone will win both. Looking at the numbers, how many MVPs or Cys does it take to be a lock for the Hall of Fame? All this on today's episode.

Natalie Fikac is an educator with over 23 years of experience. Her educational experience began as an elementary school teacher, reading interventionist and dyslexia specialist, Professional School Counselor at both the elementary and secondary level, campus administrator and district level administrator. In her previous educational experience, she served as the Director of Guidance & Counseling in Spring Branch ISD where she supported 85 Professional School Counselors, the district CYS crisis team and advocated on behalf of the 35,000 students of SBISD. She has also served as an adjunct professor at Lamar University where she taught and lead aspiring administrators. She is passionate about growing leaders, instilling self-care in those that she supports and educating and advocating on behalf of students and families in the areas of mental health, behavioral health and social-emotional needs. We talk with Natalie about the importance of the tier one supports for the mental and behavioral health, and she gives some steps that schools can take to be more intentional in the area of tier one supports.

You'll find out on this week's CYS. And, Jussie Smollett.…..wow dude.

Thank you for tuning into ConverStayShuns. Episode 7, is basically a 2018 wrap up of our experience thus far. And just want to thank everyone who has tuned into ConverStayShuns, showing support & providing feedback. Please stay tuned to what we'll have in store for next year. We'll be back early 2019!   background song "Muvyabaudi" by Cysūm. Check him out on all digital distributions iTunes, Spotify, GooglePlay, etc. Also follow him on: SoundCloud: https://soundcloud.com/cysummusic IG: http://www.instagram.com/cysummusic FB: https://www.facebook.com/Cysummusic Twitter: https://twitter.com/cysummusic YouTube: https://www.youtube.com/channel/UCnt-K5JFYjVEV5eHMmo_i-Q       Special thanks to Wild Magnolias for allowing us to have our other episodes of our podcast in their restaurant. If you're in the Austin, TX area check them out: Wild Magnolias 15424 FM 1825, Ste 240Pflugerville, TX 78660   Business page: https://wildmagnolias.business.site/ FaceBook: https://www.facebook.com/WildMagnolias/ Instagram: https://www.instagram.com/wildmagnolias/       Don’t forget to follow ConverStayShuns: FaceBook: https://www.facebook.com/conver.stayshuns Instagram: https://www.instagram.com/converstayshuns/ Twitter: https://twitter.com/converstayshuns SoundCloud: https://soundcloud.com/converstayshuns

Thank you for tuning into ConverStayShuns. On episode 6, we were having a conversation about being black. We discussed black lives matter movement vs civil rights vs gay rights. Talked about some struggles of being a black man/woman in America.   background song "Father" by Cysūm. Check him out on all digital distributions iTunes, Spotify, GooglePlay, etc. Also follow him on: SoundCloud: https://soundcloud.com/cysummusic IG: http://www.instagram.com/cysummusic FB: https://www.facebook.com/Cysummusic Twitter: https://twitter.com/cysummusic YouTube: https://www.youtube.com/channel/UCnt-K5JFYjVEV5eHMmo_i-Q       Special thanks to Wild Magnolias for allowing us to have our podcast in their restaurant. If you're in the Austin, TX area check them out: Wild Magnolias 15424 FM 1825, Ste 240Pflugerville, TX 78660   Business page: https://wildmagnolias.business.site/ FaceBook: https://www.facebook.com/WildMagnolias/ Instagram: https://www.instagram.com/wildmagnolias/       Don’t forget to follow ConverStayShuns: FaceBook: https://www.facebook.com/conver.stayshuns Instagram: https://www.instagram.com/converstayshuns/ Twitter: https://twitter.com/converstayshuns SoundCloud: https://soundcloud.com/converstayshuns

Paul answers your unpopular opinions, scorching hot takes, and thought-provoking questions in episode 5 of CYS.

Paul answers your unpopular opinions, scorching hot takes, and thought-provoking questions in episode 4 of CYS.

This conversation is split into three parts. The first part of this conversation Abi talks briefly about how after graduating and securing a job in the city of London, she made a challenging decision to commit to her dream of learning Spanish, by quitting her job and moving to Nicaragua. This conversation goes into the frank discussions of facing the unknown and realising that God' grace is still sufficient. You can catch the second and third part of this conversation on CYS soundcloud, where we go into further discussion about relationships and the challenges and consequences of being a Christian and dating someone who doesn't believe in the word of God.

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¿Conoces la diferencia entre los aminoácidos esenciales y los no esenciales? ¿Sabes cuáles son las funciones de estos últimos? Hoy vamos a hablarte sobre cuáles son los aminoácidos no esenciales y cuáles son sus funciones, para conocer más a fondo las sustancias que pueblan el cuerpo humano. ¿Qué son los aminoácidos No esenciales? Los aminoácidos son unas pequeñas moléculas que se encargan de formar las proteínas y de realizar muchísimas funciones, vitales para el organismo. Existen dos tipos diferenciados. Es importante mencionar que las dos clasificaciones que os mostramos a continuación varían según la especie e incluso, para algunos aminoácidos, según los autores, ya que hay científicos que difieren sobre la pertenencia de alguno a uno u otro grupo. A continuación os dejamos con la clasificación más aceptaba actualmente. Por un lado tenemos los aminoácidos esenciales, que son todos aquellos que tenemos que ingerir mediante la alimentación porque nuestro cuerpo no los puede generar y que son: Leucina (Leu), Lisina (Lys), Metionina (Met), Fenilalanina (Phe), Treonina (Thr), Triptófano (Trp), Valina (Val), Histidina (His) y Arginina (Arg). La carencia de este tipo de aminoácidos en la dieta puede provocar problemas y limitaciones en el organismo, ya que los necesita para llevar a cabo diversas funciones en los tejidos o en los órganos del cuerpo humano. Pero también existen los aminoácidos no esenciales, los que fabrica y sintetiza nuestro propio cuerpo sin necesidad de buscarlos externamente. Los aminoácidos no esenciales son: Tirosina (Tyr), Aspartato (Asp), Cisteína (Cys), Glutamato (Glu), Glutamina (Gln), Glicina (Gly), Prolina (Pro), Serina (Ser) y Asparagina (Asn). ¿Quieres saber cuáles son las importantes funciones de todos estos aminoácidos no esenciales? Continúa leyendo y descúbrelo a continuación. Las funciones de los aminoácidos No esenciales Una vez conocía la diferencia entre los aminoácidos y los aminoácidos no esenciales, pasamos a descubrir cuáles son las funciones en nuestro organismo de los aminoácidos no esenciales. Las funciones de los aminoácidos no esenciales son las siguientes: -Glutamato. o ácido glutámico es uno de los aminoácidos más abundantes del organismo y un comodín para el intercambio de energía entre los tejidos. Se considera un aminoácido no esencial porque se puede sintetizar en muchos tejidos, teniendo un papel fundamental en el mantenimiento y el crecimiento celular. Es el neurotransmisor excitatorio por excelencia de la corteza cerebral humana. Su papel como neurotransmisor está mediado por la estimulación de receptores específicos, denominados receptores de glutamato. Todas las neuronas contienen glutamato, pero sólo unas pocas lo usan como neurotransmisor. Desempeña un papel central en relación con los procesos de transaminación y en la síntesis de distintos aminoácidos que necesitan la formación previa de este ácido, como es el caso de la prolina, hidroxiprolina, ornitina y arginina. Se acumula en proporciones considerables en el cerebro (100-150 mg / 100 g de tejido fresco). Es uno de los aminoácidos más activos metabólicamente. Es un sustrato para la síntesis de proteínas y un precursor del metabolismo anabólico en el músculo mientras que regula el equilibrio ácido/básico en el riñón y la producción de urea en el hígado. Varios estudios han demostrado que el estómago, intestino, páncreas y bazo consumen un 95% del ácido glutámico ingerido en la dieta, con lo que es importante tomar una dieta rica en proteínas para no alterar el equilibrio de aminoácidos con acceso al resto del organismo después de este paso inicial de nutrientes por el aparato digestivo. -Serina. Fundamental en la metabolización de las grasas, para el sistema inmunológico y la formación de algunos neurotransmisores. La serina desempeña un importante papel en la función catalítica de muchas enzimas. Se ha demostrado que esto ocurre en los sitios activos de la quimotripsina, la tripsina, y muchas otras enzimas. Como componente de las proteínas, su cadena lateral puede sufrir O-glicosilación, en la que puede haber una relación funcional con la diabetes. Es uno de los tres residuos de aminoácidos que son comúnmente fosforilados por las quinasas en la señalización celular en organismos eucariotas. -Tirosina. La tirosina es fundamental para nuestro estado de ánimo, ya que interactúa con neurotransmisores como la adrenalina o la dopamina, y con la norepinegrina y la epinefrina. Funciones de la tirosina • Forma parte del funcionamiento correcto del sistema nervioso central. • Interactúa con la adrenalina o la dopamina, regulando el estado de ánimo. También con la norepinefrina y la epinefrina. • Fundamental para el metabolismo. • Minimiza la absorción y almacenamiento de determinadas grasas. • Efecto positivo en la mucosa de la piel y el pelo. • Estimula la mielina. • Influye en otras hormonas como la tiroides, siendo beneficiosa para personas con trastornos de tiroides. Las enfermedades relacionadas con el metabolismo de la tirosina son la Tirosinemia, alcaptonuria, el parkinson o el albinismo Influye en hormonas como la tiroides, de ahí que de forma conjunta con el yodo, desde un punto de vista médico sea útil en personas con trastornos de tiroides. -Cisteína. Sintetizada por el hombre en condiciones normales a partir de la metionina. También está presente en alimentos proteicos como leche, queso, carne. Es un nutriente esencial que actúa como antioxidante, protegiendo a nuestro organismo contra el daño por radiación, y protegiendo a su vez tanto al hígado como al cerebro de daños causados por determinadas toxinas (como compuestos tóxicos del cigarrillo, el alcohol o las drogas). Recientemente se ha descubierto que puede ser un nutriente interesante en el tratamiento de la obesidad, ya que promueve la quema de grasas. Funciones de la cisteína • Actúa como antioxidante. • Protege al organismo contra el daño por radiación. • Protege tanto al hígado como al cerebro de la acción de diferentes toxinas. • Promueve la recuperación ante cirugía o quemaduras. • Ayuda a quemar la grasa. • Participa en la formación de músculos. -Glicina. Necesaria para depurar el organismo. El hígado usa la glicina para eliminar tóxicos y formar las sales biliares. Incrementa el nivel de creatinina somatotrofinas en la musculatura. Funciones de la glicina • Necesita del sodio y el cloro para su correcta absorción, y de serina para su fabricación. • Mantiene un correcto funcionamiento de la cicatrización. • Interviene en la producción de colágeno y fosfolípidos. • Propicia la producción de la hormona del crecimiento. • Ayuda a un correcto funcionamiento cerebral. • Previene enfermedades infecciosas. -Aspagarina. Es importante en los procesos el SNC (sistema nervioso central) y en la síntesis del amoniaco. Funciones que desempeña: Estas son algunas de las funciones que cumple en el organismo: Tiene una destacada función en la actividad cerebral. Colabora en la síntesis de las glucoproteínas. Junto a la vitamina B6, es precursor del neurotransmisor GABA (ácido gamma aminobutírico), cuya acción sedante sobre el sistema nervioso es importante. La asparagina interviene en los procesos metabólicos del sistema nervioso central. Juega un papel importante en la síntesis del amoníaco. Ayuda a sintetizar la masa muscular del cuerpo. . Su déficit puede provocar: Su carencia puede ocasionar una serie de trastornos en el organismo, estos son algunos de ellos: Alteraciones en el sistema nervioso. Alteraciones metabólicas. Alteraciones en las funciones cerebrales. Aumento de la irritabilidad. Dolores de cabeza. Trastornos de la memoria. . -Prolina. Importante para el colágeno presente en cartílagos, tendones y la piel. Funciones de la prolina • Fortalece las articulaciones y los tendones. • Ayuda en el fortalecimiento de los músculos del corazón. • Ayuda en la producción de colágeno. • Mejora la textura de la piel. • Reduce el riesgo de pérdida de colágeno. • Ayuda en la cicatrización tanto de tejidos como de mucosas. • Ayuda en la inmunidad de nuestro organismo al relacionarse con el mantenimiento de algunas inmunoglobulinas. Es útil en el fortalecimiento de las articulaciones y los tendones. De ahí que este aminoácido no esencial sea utilizado en la prevención de la artritis, al conservar las articulaciones. -Aspartato. Fundamental para reducir el nivel de amoniaco en sangre después del ejercicio físico. Funciones del ácido aspártico • Acción desintoxicante del sistema sanguíneo. • Favorece la correcta circulación sanguínea. • Ayuda en la eliminación de las toxinas, a través del hígado y los riñones. • Aumenta la resistencia, ayudando en caso de depresión, cansancio o fatiga crónica. • Rejuvenece la actividad celular. • Ayuda en la formación de células, y en el funcionamiento del metabolismo. -Glutamina. Muy abundante en la musculatura, tiene importancia en el metabolismo cerebral. Funciones de la glutamina • Forma parte de los músculos y de la sangre. • Ayuda a construir y mantener el tejido muscular. • Participa en la regeneración de las mucosas intestinales. • Previene el desgaste muscular. • Aumenta la actividad mental y favorece una correcta función cerebral. • Mantiene el equilibrio del ácido alcalino en el cuerpo. Es especialmente útil para estudiantes, ya que ayuda a aumentar tanto la actividad mental como el funcionamiento del cerebro. Ya que participa en la regeneración de las mucosas intestinales, es un aminoácido que ayuda a mantener un sistema digestivo sano, reduciendo a su vez el tiempo de curación de las úlceras. Alimentos: Al igual que todos los aminoácidos, está presente, sobre todo, en productos de origen animal, carne, pescado, huevos, lacteos y, en menor medida, en legumbres, cereales, semillas y frutos secos. Alimentos: Al igual que todos los aminoácidos, está presente, sobre todo, en productos de origen animal, carne, pescado, huevos, lacteos y, en menor medida, en legumbres, cereales, semillas y frutos secos. Alimentos: Al igual que todos los aminoácidos, está presente, sobre todo, en productos de origen animal, carne, pescado, huevos, lacteos y, en menor medida, en legumbres, cereales, semillas, frutos secos y alimentos ricos en Vitamina C.

Tonight's special guest is Lee Parker from Pittsburgh, PA, an abuse survivor and activist for changing the Statutes of Limitations. At 13 years old he was abused while under Children and Youth Services (foster care) by a staff member. Eventually the man filed through the group home and CYS for Lee to become his foster child. After being approved, Lee went to stay with his abuser. The man would come to his bed to molest him after he was asleep. This went on a couple times a week for over a year. Lee explains, "The day I broke down I was in school. At the end of the day when it was time to leave I told my teacher I didn't want to go home. I was crying and wouldn't stop so my teacher sent me to the nurse's office. She soon realized I was being sexually abused at home and she called the police. That's when I was taken from my abusers care." Lee still suffers from knowing nobody protected him while he was in the care of CYS. He says, "It took a toll for the worst on my life. At times I think about death. Its like I've been killed emotionally. I go through life pretending things are fine. I smile but really I just cry on the inside. I'm torn into pieces that can't be put back together." Now 31 years old, Lee has come forward to seek justice from Children and Youth Services, the institution where he met his abuser. But he's discovered the statue of limitations blocks him from seeking justice. Disappointed, Lee explains, "In some states there's no statue of limitations. Just like murder there should be no statue of limitations. A victim should [be able to] take all the time he/she needs."

Selenocysteine (Sec) is the 21st amino acid. Unlike other amino acids incorporation of Sec into proteins is more complex by far as it is encoded by the opal stop codon UGA. A complex and highly sophisticated incorporation mechanism is required in order to assure the correct co-translational incorporation of Sec into the nascent polypeptide chain. Even after years of intensive research the question as to why selenoproteins are important for mammalian life has not been fully understood. This study aimed to provide answers to this question using gluthathione peroxidase 4 (GPx4) as a model enzyme. It has been shown that GPx4 is essential for early embryogenesis, neuro- and retina-protection and male fertility in mice. But the role of selenothiol- versus thiol-based GPx4 catalysis in cells and mice, as well as the role of the catalytic tetrad in GPx4 catalysis and the subcellular localisation of the different GPx4 isoforms and their impact on cell protection have remained unclear. Therefore, a series of mutant variants of GPx4 were generated by site-directed mutagenesis, stably expressed in tamoxifen-inducible GPx4 knockout cells (Seiler et al., Cell Metab 2008), and functionally analysed. GPx4 mutant variants included those of the peroxidatic Sec, the catalytic tetrad, the mitochondrial leader sequence (Mls) and the non-peroxidatic cysteines. These studies revealed that Cys can functionally replace Sec in the active centre of GPx4 to a large extent in cells, whereas some amino acids of the catalytic site are necessary for GPx4 function. None of the non-peroxidatic Cys were shown to be required for the cell-protective function of GPx4, ruling out a possible resolving Cys in the catalytic cycle of GPx4 unlike homologues in other organisms that use a resolving Cys. The fuction of a resolving Cys is to start a nucleophilic attack upon the intermolecular bond between the peroxidatic Cys and the substrate in order to create an intramolecular disulfidbride. Apparently subcellular localization of GPx4 in the extramitochondrial/cytosolic compartment is crucial for its cell death preventing qualities as overexpression of mitochondrial GPx4 in the knockout cells failed to rescue cell death induced by endogenous GPx4 disruption.

Phycobilins are light harvesting pigments of cyanobacteria and red algae. In cyanobacteria, four phycobiliproteins are organized in phycobilisomes: phycocyanin (PC), allophycocyanin (APC), and often also phycoerythrocyanin (PEC) or phycoerythrin (PE). Their phycobilin chromophores, linear tetrapyrroles, are generally bound to the apoprotein at conserved positions by cysteinyl thioether linkages. A final step in phycobiliprotein biosynthesis is the post-translational phycobilin addition to the various biliproteins. In vivo, the correct attachment of most chromophores is catalyzed by binding-site and chromophore-specific lyases. Only two such lyases, which both belong to the E/F-type were known at the beginning of this work. Two additional types, S/(U)-type and T-type lyase, have been characterized during this work. In addition, the correct structures of the products from all three lyase types have been verified, and evidence was obtained for the reaction mechanisms. This characterization relied on two methodological advances. The first is the use of a multi-plasmidic expression system for reconstitution of phycobiliproteins in E. coli. After cloning of apophycobiliprotein genes, phycobilin biosynthesis genes and (putative) lyase genes from several cyanobacteria, various phycobiliproteins could be biosynthesized in the heterologous E. coli system using dual plasmids containing the respective genes. This heterologous system produces higher yields than the in vitro reconstitution, it is nearly devoid of spontaneous binding, better reproducible, and more easily controlled. The second methodological advance is the consequent use of a combination of chromatographic, electrophoretic and spectroscopic tools that allowed a full characterization of the structure and binding sites of attached chromophores. This included, besides optical spectroscopy, in particular mass and magnetic resonance (1H-NMR) spectroscopy. Using the unmodified genes coding for both subunits of PEC, as well as their cystein mutants, three lyases were identified for the three binding site. Besides the already known isomerizing lyase, PecE/PecF, for Cys-84 of α-PEC, these are the two new lyases, CpcT (all5339) for Cys-153 of β-PEC, and CpcS (alr0617) for Cys-82 of β-PEC. The spectroscopic analysis proved that the chromophores (PCB and PVB)are correctly attached to these three binding sites. Similarly, three lyases were identified for the three binding sites of CPC. The well known heterodimeric lyase (CpcE/CpcF) catalyzes the covalent attachment of PCB to αC84 of CPC, CpcS catalyses the site-selective attachment of PCB to cysteine-β84 in CpcB; and CpcT for cysteine-β155 of CpcB. CpcE/F is specific for CpcA, while CpcS and CpcT can react with both CpcB and PecB. We also tested the lyase activity of the deoxyhyposyl-hydroxylase (DOHH) from the malaria parasite, Plasmodium falciparum. This enzyme has Heat-like repeats that are characteristic for the E/F-type lyases, but it had not chromophore-attaching activity. The substrate specificity of the new lyase, CpcS (coded by alr0617), was further tested with APC subunits; It is very unspecific with regard to the acceptor protein and attaches PCB to ApcA1, ApcB, ApcD ApcF, as well as to the product of an additional gene, apcA2; of unknown function that is highly homologous to apcA1 coding for the APC α-subunit. Obviously, this lyase has a much broader substrate specificity than the E/F-type lyases, but it has high site-specificity, attaching the chromophore exclusively to the Cys-84 (consensus sequence) binding site of the APC subunits. CpcS from Anabaena PCC7120 is a relatively simple system, it acts as a monomer, and does not require any cofactors. CpcS binds PCB rapidly (

Genetic interaction as a mechanism for the generation of mutations is suggested by recurrent, multiple nucleotide substitutions that are identical to nucleotide sequences elsewhere in the genome. We have sequenced the mutant K gene from the bm6 mouse, which is one of a series of eight closely related, yet independently occuring mutants known collectively as the "bg series." Two changes from the Kb gene are found, positioned 15 nucleotides apart: an A-to-T change and a T-to-C change in the codons corresponding to amino acids 116 and 121, resulting in Tyr-to-Phe and Cys-to-Arg substitutions, respectively. Hybridization analysis with an oligonucleotide specific for the altered Kbm6 sequence identifies one donor gene, Q4, located in the Qa region of the H-2 complex. The two altered nucleotides that differentiate Kbm6 and Kb are present in Q4 in a region where Kb and Q4 are otherwise identical for 95 nucleotides, delineating the maximum genetic transfer between the two genes. Because the Kbm6 mutation arose in an homozygous mouse these data indicate that the Q4 gene contains the only donor sequence and demonstrates that Q-region gene sequences can interact with the Kb gene to generate variant K molecules.