Podcasts about randomized controlled trials

Listener discretion is advised! References: Buttner & Arlanger. (May 3, 2022). ST depression does not localise. Available: https://litfl.com/st-depression-does-not-localise/ Cannon, J. W., Khan, M. A., Raja, A. S., et al. (2017). Damage control resuscitation in patients with severe traumatic hemorrhage. Journal of Trauma and Acute Care Surgery, 82, 605-617. Kabra, R., Acharya, S., Kamat, S., & Kumar, S. (2022). ST-Segment Elevation in Lead aVR With Global ST-Segment Depression: Never Neglect Left Main Coronary Artery (LMCA) Occlusion. Cureus. Lee, G.-K., Hsieh, Y.-P., Hsu, S.-W., Lan, S.-J., & Soni, K. (2019). Value of ST‐segment change in lead aVR in diagnosing left main disease in Non‐ST‐elevation acute coronary syndrome—A meta‐analysis. Annals of Noninvasive Electrocardiology, 24. Morrison, C. A., Carrick, M. M., Norman, M. A., et al. (2011). Hypotensive Resuscitation Strategy Reduces Transfusion Requirements and Severe Postoperative Coagulopathy in Trauma Patients With Hemorrhagic Shock: Preliminary Results of a Randomized Controlled Trial. Journal of Trauma: Injury, Infection & Critical Care, 70, 652-663. Rossaint, R., Afshari, A., Bouillon, B., et al. (2023). The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition. Critical Care, 27. Tamura, A. (2014). Significance of lead aVR in acute coronary syndrome. World Journal of Cardiology, 6(7), 630. Uthamalingam, S., Zheng, H., Leavitt, M., Pomerantsev, E., Ahmado, I., Gurm, G. S., & Gewirtz, H. (2011). Exercise-Induced ST-Segment Elevation in ECG Lead aVR Is a Useful Indicator of Significant Left Main or Ostial LAD Coronary Artery Stenosis. JACC: Cardiovascular Imaging, 4, 176–186. Weymouth, W., Long, B., Koyfman, A., & Winckler, C. (2019). Whole Blood in Trauma: A Review for Emergency Clinicians. The Journal of Emergency Medicine, 56, 491-498. Wang, A., Singh, V., Duan, Y., Su, X., Su, H., Zhang, M., & Cao, Y. (2020). Prognostic implications of ST‐segment elevation in lead aVR in patients with acute coronary syndrome: A meta‐analysis. Annals of Noninvasive Electrocardiology, 26.

To taurine or not to taurine, that is the question. This episode features audio from: Randomized Controlled Trials of Taurine Supplementation in Humans Caveats and Side Effects of Taurine Supplements The Best Daily Dose of Taurine Visit the video pages for all sources and doctor’s notes related to this podcast.  

LBCT: Interleukin-6 Inhibition in Acute Myocardial Infarction at Risk of Cardiogenic Shock: A Randomized Controlled Trial

Dietary interventions were put to the test for major mental illness.

Urolithin A (MitoPure)--Mitophagy, Muscle Recovery, Immunity, and Skin Health: Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company, details urolithin A (MitoPure), a postbiotic derived from pomegranate precursors that most people cannot produce due to microbiome differences. Currier explains MitoPure's mechanism—stimulating mitophagy to recycle dysfunctional mitochondria—and reviews evidence from multiple clinical trials. He reveals a Sports Medicine study in elite male distance runners showing reduced creatine kinase and lower perceived exertion, suggesting improved recovery, plus trials in middle-aged and older adults showing improvements in strength, six-minute walk test, and VO2 max at 500 mg–1 g doses. They also cover a Nature Aging immune study reporting rejuvenation of stem-like CD8 T cells with improved mitochondrial fatty acid oxidation, ongoing research directions, supplement quality/testing for athletes, and topical urolithin A skincare trials and partnerships, including L'Oréal Lancôme.

Join host Melissa Middeldorp and her guests Marco Perez and Kristie Coleman for this installment of The Lead! This multicenter randomized controlled trial evaluated whether smartwatch-based rhythm monitoring improves detection of previously undiagnosed atrial fibrillation (AF) in cardiology outpatients aged ≥65 years with elevated stroke risk. A total of 437 participants were randomized to either 6-month monitoring with an Apple Watch integrating photoplethysmography-based irregular rhythm detection and single-lead ECG confirmation, supported by a telemonitoring adjudication pathway, or to standard care. The primary endpoint of new AF occurred significantly more often in the intervention group than in controls (9.6% vs 2.3%; HR 4.40), with many cases asymptomatic and detected earlier through wearable monitoring. All diagnosed patients were initiated on anticoagulation, and major adverse cardiovascular events were similar between groups. Overall, the study demonstrates that prolonged smartwatch-based screening embedded within a clinical workflow substantially increases AF detection in a high-risk population, highlighting the feasibility of wearable-enabled case finding while underscoring ongoing questions regarding clinical outcomes and optimal implementation. Learning Objectives Describe the design and key findings of a randomized trial evaluating smartwatch-based screening for atrial fibrillation in older patients at elevated stroke risk. Discuss the clinical implications, limitations, and broader evidence context of wearable-enabled atrial fibrillation detection within contemporary screening strategies.   Article Authors Nicole J. van Steijn, Isabel S. Blommestijn, Sebastiaan Blok, Shari Pepplinkhuizen, Aernout Somsen, Reinoud E. Knops, Laura Breukel, Jan G.P. Tijssen, Igor I. Tulevski, Philip M. Croon, Michiel M. Winter Podcast Contributors Melissa E. Middeldorp, MPH, PhD Kristie Coleman, MPH, RN Marco Perez, MD Host and Contributor Disclosure(s): M. MiddeldorpNothing to disclose. K. Coleman •Honoraria/Speaking/Teaching/Consulting: Medtronic M. Perez •Honoraria/Teaching/Speaking/Consulting: Boston Scientific, Biontronik •Ownership/Partnership: QALY •Research: Apple, Inc.  

Contributor: Aaron Lessen, MD Educational Pearls: Patients with pulmonary embolism (PE) are divided into three risk categories Low risk (non-massive PE): patients are stable Treatment: prescribe anticoagulants and discharge home Intermediate risk (submassive PE): patients are stable but display evidence of clot burden such as elevated troponin, elevated BNP, and/or right heart strain Treatment is controversial High risk (massive PE): patients are unstable with hypotension, hypoxia, and/or respiratory distress Treatment: IV thrombolysis to prevent decompensation A recent randomized controlled trial evaluated treatment of intermediate risk PE patients Patients were randomized to receive either thrombectomy with anticoagulation or anticoagulation alone The primary outcome evaluated changes in right ventricular enlargement at 48 hours A controversial primary outcome because it does not speak to mortality or incidence of other necessary aggressive interventions Low clinical significance The study found that thrombectomy significantly reduced right ventricular enlargement faster than anticoagulation alone. However, there was no statistical difference in mortality or need for other treatments Treatment for intermediate risk PE patient remains controversial The same study will have second follow-up at 90 days to see if there are other benefits References Lookstein RA, Konstantinides SV, Weinberg I, Dohad SY, Rosol Z, Kopeć G, Moriarty JM, Parikh SA, Holden A, Channick RN, McDonald B, Nagarsheth KH, Yamada K, Rosovsky RP; STORM-PE Trial Investigators. Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial. Circulation. 2026 Jan 6;153(1):21-34. doi: 10.1161/CIRCULATIONAHA.125.077232. Epub 2025 Nov 3. PMID: 41183181. Summarized by Meg Joyce, MS2 | Edited by Meg Joyce & Jorge Chalit, OMS4 Donate: https://emergencymedicalminute.org/donate/

Send us Fan MailDescription: An immersive reading of Sommelier by by Suraj Bala with reflection on reflection, death, resurrection, candles and em dashes. Work:Poem: https://jamanetwork.com/journals/jamaoncology/article-abstract/2839156Bala S. Sommelier. JAMA Oncol. 2025;11(11):1399. doi:10.1001/jamaoncol.2025.2896References: Meditation for the Primary and Secondary Prevention of Cardiovascular Disease. Rees K, Takeda A, Court R, et al. The Cochrane Database of Systematic Reviews. 2024;2:CD013358. doi:10.1002/14651858.CD013358.pub2.Meditation Programs for Psychological Stress and Well-Being: A Systematic Review and Meta-Analysis. Goyal M, Singh S, Sibinga EM, et al. JAMA Internal Medicine. 2014;174(3):357-68. doi:10.1001/jamainternmed.2013.13018.Inner Engineering Practices and Advanced 4-Day Isha Yoga Retreat Are Associated With Cannabimimetic Effects With Increased Endocannabinoids and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators. Sadhasivam S, Alankar S, Maturi R, et al. Evidence-Based Complementary and Alternative Medicine : eCAM. 2020;2020:8438272. doi:10.1155/2020/8438272.Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials. Kim DY, Hong SH, Jang SH, et al. International Journal of Environmental Research and Public Health. 2022;19(3):1244. doi:10.3390/ijerph19031244.

Zara M. Patel, MD, Professor of Otolaryngology–Head and Neck Surgery at Stanford Medicine and Director of the Stanford Initiative to Cure Smell and Taste Loss, discusses her pursuit of a cure for olfactory dysfunction, the science behind smell recovery, and the research milestones that have redefined what is possible for patients with smell and taste loss. Dr. Patel reflects on her cross-country training journey, the curiosity-driven path that led her into an underexplored corner of the specialty, and how olfactory training and platelet-rich plasma (PRP) injections went from novel ideas to evidence-based treatments. The conversation also covers the biology of olfactory nerve regeneration, the importance of mentorship in building an academic career, and the expanding frontier of neuro-rhinology. This episode is featured as part of celebrating WIO Day every March 8. Helpful Resources: Links for physicians and patients watching this: Stanford Initiative to Cure Smell and Taste Loss: https://med.stanford.edu/content/sm/smell.html/ Patient education page for Olfactory Training: https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2782042 PRP studies:Pilot study: https://pubmed.ncbi.nlm.nih.gov/32337347/ Randomized Controlled Trial: https://pubmed.ncbi.nlm.nih.gov/36507615/ Long term follow-up cohort study: https://pubmed.ncbi.nlm.nih.gov/39740091/ Systematic Evidence Based Review of PRP use in all fields of ENT: https://pubmed.ncbi.nlm.nih.gov/38914822/ Case Report for use in Post-Traumatic Anosmia: https://pubmed.ncbi.nlm.nih.gov/39913151/

In this episode of Disruption/Interruption, KJ sits down with Tracy MacNeal, CEO of Maternal Medical, to discuss a long-overlooked crisis in women's health: birth injuries. Tracy reveals how 10-15% of women who deliver vaginally experience severe pelvic floor trauma—injuries that often go undiagnosed and untreated for years. She shares how her company is developing groundbreaking technology to prevent these injuries during childbirth and why this space has been so dramatically underinvested. This conversation exposes the silence around maternal health and the urgent need for innovation in the delivery room. Four Key Takeaways: [11:28] The Hidden Epidemic of Birth Injuries - 10-15% of women who deliver vaginally suffer pelvic floor muscles torn off the bone—an injury only visible through ultrasound or MRI. This leads to pelvic organ prolapse, incontinence, and chronic pain, yet most women leave the hospital without knowing they've been injured. [5:22] Innovation Has Been Stalled for 80 Years - The epidural, introduced in the 1940s, was the last major innovation in labor and delivery. Unlike other medical fields that see constant advancement, maternal health has been dramatically underinvested, creating an anemic ecosystem for research and development. [20:12] Smart Technology That Listens to the Body - Maternal Medical's device gently pre-stretches the birth canal by listening to the mother's tissue and only expanding one millimeter at a time when the body relaxes. In clinical trials of over 200 patients, the device group had zero injuries compared to 11% in the control group. [30:58] The Power of Speaking Up - Women's silence about their symptoms has perpetuated the problem. When women speak up about birth injuries, it signals to investors that patients care and pushes physicians to prioritize these issues. Advocacy drives innovation and funding in healthcare. Quote of the Show (28:27):"Unless she's a fighter pilot, having a baby is the most dangerous thing most women will ever do."- Tracy MacNeal Join our Anti-PR newsletter where we’re keeping a watchful and clever eye on PR trends, PR fails, and interesting news in tech so you don't have to. You're welcome. Want PR that actually matters? Get 30 minutes of expert advice in a fast-paced, zero-nonsense session from Karla Jo Helms, a veteran Crisis PR and Anti-PR Strategist who knows how to tell your story in the best possible light and get the exposure you need to disrupt your industry. Click here to book your call: https://info.jotopr.com/free-anti-pr-eval Ways to connect with Tracy MacNeal: LinkedIn: https://www.linkedin.com/in/tracymacneal/Company Website: https://maternamed.com How to get more Disruption/Interruption: Amazon Music - https://music.amazon.com/podcasts/eccda84d-4d5b-4c52-ba54-7fd8af3cbe87/disruption-interruption Apple Podcast - https://podcasts.apple.com/us/podcast/disruption-interruption/id1581985755 Spotify - https://open.spotify.com/show/6yGSwcSp8J354awJkCmJlDSee omnystudio.com/listener for privacy information.

Un nouvel épisode du Pharmascope est disponible! Dans ce 173e épisode, Nicolas, Olivier et Amélie discutent de la prise en charge de l'hypothyroïdie dans divers contextes: hypothyroïdie subclinique, personnes âgées, grossesse, et plus encore!  Les objectifs pour cet épisode sont les suivants: Discuter des évidences portant sur le traitement de l’hypothyroïdie subclinique Discuter de la prise en charge de l’hypothyroïdie chez la personne âgée Discuter du dépistage et de la prise en charge de l’hypothyroïdie subclinique et clinique durant la grossesse Ressources pertinentes en lien avec l'épisode Moon S, et coll. Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies. Thyroid. 2018 Sep;28(9):1101-1110. Stott DJ, et coll.; TRUST Study Group. Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. N Engl J Med. 2017 Jun 29;376(26):2534-2544. Feller M, et coll. Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis. JAMA. 2018 Oct 2;320(13):1349-1359. Ringel MD, et coll. 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer. Thyroid. 2025 Aug;35(8):841-985 Thyroid Disease in Pregnancy: ACOG Practice Bulletin, Number 223. Obstet Gynecol. 2020 Jun;135(6):e261-e274. Sankoda A, et coll. Effects of Levothyroxine Treatment on Fertility and Pregnancy Outcomes in Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Thyroid. 2024 Apr;34(4):519-530. Casey BM, et coll; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy. N Engl J Med. 2017 Mar 2;376(9):815-825. Negro R, et coll. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. J Clin Endocrinol Metab. 2010 Apr;95(4):1699-707. Ringel MD, et coll. 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer. Thyroid. 2025 Aug;35(8):841-985.

Dr. Mike Maddaleni reviews the No. 4 article of 2024, titled “Analysis of the Effect of Different Physical Exercise Protocols on Depression in Adults: Systematic Review and Meta-analysis of Randomized Controlled Trials,” which was originally published in Sports Health in March 2024. Dr. Jeremy Schroeder serves as the series host. Dr. Maddaleni is a member of the Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2024, as selected for the 2025 AMSSM Annual Meeting. Analysis of the Effect of Different Physical Exercise Protocols on Depression in Adults: Systematic Review and Meta-analysis of Randomized Controlled Trials: https://journals.sagepub.com/doi/10.1177/19417381231210286

Send a textIm Rahmen der Simulationswoche der Anästhesiologie 2026 sprechen wir über den Stellenwert von Simulationstraining in der Aus- und Weiterbildung. Wie belastbar ist die Evidenz? Welche Kompetenzen werden tatsächlich verbessert? Und warum ist der direkte Nachweis eines Effekts auf Patientenergebnisse methodisch so schwierig?Simulationstraining ist in der Anästhesiologie evidenzbasiert eine effektive Methode zur Verbesserung von theoretischem Wissen, praktischen Fertigkeiten und nicht-technischen Kompetenzen wie Teamarbeit, Kommunikation und Problemlösung. Mehrere Meta-Analysen und systematische Reviews zeigen, dass simulationsbasierte Trainingsformate im Vergleich zu nicht-simulationsbasierten Ansätzen signifikant bessere Ergebnisse in Wissenstests, technischen Skills und der Entwicklung nicht-technischer Kompetenzen erzielen [1,2].Insbesondere die Förderung von Teamleistung und interdisziplinärer Kommunikation wird als zentraler Mehrwert hervorgehoben, da gerade in hochdynamischen und sicherheitskritischen Situationen – wie perioperativen Krisen – die Koordination im Team entscheidend ist [3,4]. Simulation ermöglicht das strukturierte Training von Crisis Resource Management (CRM), Entscheidungsfindung unter Stress sowie standardisierter Kommunikation.Moderne Simulationstechnologien, einschließlich Virtual-Reality-basierter Anwendungen, erweitern das Spektrum der Trainingsmöglichkeiten. Sie erlauben risikofreies Üben komplexer Szenarien und technischer Prozeduren, insbesondere in Hochrisikobereichen wie der geburtshilflichen Anästhesie [4,5]. Simulation wird daher zunehmend als integraler Bestandteil der anästhesiologischen Aus- und Weiterbildung angesehen und von Expert:innen als verpflichtender Bestandteil strukturierter Curricula gefordert [3,9].Die Evidenz für eine direkte Verbesserung klinischer Patientenergebnisse durch Simulationstraining ist hingegen bislang limitiert. Zwar existieren Hinweise auf positive Effekte in spezifischen Kontexten, robuste und kausal belastbare Outcome-Daten sind jedoch selten [2,6–8]. Die meisten Studien belegen Verbesserungen auf Ebene von Wissen, technischen Fertigkeiten und Teamperformance, während der Transfer in harte klinische Endpunkte weiterhin Gegenstand aktueller Forschung ist.Zusammenfassend ist Simulationstraining in der Anästhesie klar evidenzbasiert wirksam hinsichtlich Kompetenzentwicklung – insbesondere technischer und nicht-technischer Fähigkeiten – während der direkte Nachweis eines Effekts auf Patientenergebnisse methodisch anspruchsvoll bleibt. Unabhängig davon wird Simulation als zentrales Instrument moderner Patientensicherheit und kontinuierlicher professioneller Entwicklung betrachtet.Weiterführende LiteraturSu Y, Zeng Y. Simulation Based Training Versus Non-Simulation Based Training in Anesthesiology: A Meta-Analysis of Randomized Controlled Trials. Heliyon. 2023;9(8):e18249. doi:10.1016/j.heliyon.2023.e18249.Lorello GR, Cook DA, Johnson RL, Brydges R. Simulation-Based Training in Anaesthesiology: A Systematic Review and Meta-Analysis. British Journal of Anaesthesia. 2014;112(2):231–245. doi:10.1093/bja/aet414.Krage R, Erwteman M. State-of-the-Art Usage of Simulation in Anesthesia: Skills and Teamwork. Current Opinion in Anaesthesiology. 2015;28(6):727–734. doi:10.1097/ACO.0000000000000257.Abrams J, Mahoney B. The Importance of Simulation-Based Multi Professional Training in Obstetric Anesthesia: An Update. Current Opinion in Anaesthesiology. 2024;37(3):239–244. doi:10.1097/ACO.0000000000001352.Wang W, Gao L, Lin Y, Gao P. Virtual Reality Is Emerging Training Applications for Anesthesia Simulation.European Journal of Medical Research. 2025;30(1):768. doi:10.1186/s40001-025-03054-9.Marynen F, Van Gerven E, Van

Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing PTSD in a cohort of combat-bound soldiers.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the March issue into context. 00:57   Attention bias modifications 03:54   Response-time and gaze-contingent paradigms 05:05   Differences in efficacy between the two arms 08:06   Ethical considerations in investigating combat-bound soldiers 10:44   Controlling for combat experiences in studying PTSD 12:24   Duration of the effect 13:44   Limitations 15:03   Immediate clinical implications 16:22   Further research 17:05   Kalin interview 17:22   Dykan et al. 21:03   Kaul et al. 26:19   Kantrowitz et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

How do you make an embryo stick? Is there anything you can do to improve embryo transfer success? And how do you know which advice is science-backed versus fertility folklore?  In this special solo Q&A episode of Brave & Curious, Dr. Lora Shahine answers the questions patients ask most often when preparing for an embryo transfer. What really matters during an IVF embryo transfer? Using real questions from Instagram, YouTube, and her own practice, she walks listeners through fresh vs. frozen embryo transfer, what happens on transfer day, whether you need a full bladder, lying down afterward, Valium use, pineapple cores, French fries, genetic testing, ERA testing, and how uterine lining preparation actually works. Listeners will come away with a clearer understanding of embryo transfer success rates, frozen embryo transfer protocols, and implantation timing, and get their real questions answered. In this episode you'll hear: [1:27] What should I expect on transfer day? [8:00] What happens post-transfer? [9:35] Funny myths: pineapple cores & McDonalds french fries [13:46] Fresh vs. frozen transfer myths [20:18] Pre-transfer testing and ERA [24:37] Natural vs. medicated transfer protocols [28:30] Conclusion & final thoughts Links and Resources: Embryo Transfer: What to Expect on YouTube Does the Embryo Fall Out: Embryo Transfer Tips on YouTube Fresh vs. Frozen Transfers: Pros and Cons on YouTue Studies Mentioned: Randomized Controlled Trial for FET Protocols: PMID: 38944045 Retrospective analysis Perinatal Outcomes with FET protocols PMID:33926401 Randomized Controlled Trial for ERA before FET PMID: 36472596 Randomized Controlled Trial Bedrest after embryo transfer: PMID:31520259 Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books

Dr. Christie Langenberg reviews the No. 7 article of 2024, titled “Platelet-Rich Plasma Versus Alternative Injections for Osteoarthritis of the Knee: A Systematic Review and Statistical Fragility Index-Based Meta-analysis of Randomized Controlled Trials,” which was originally published in The American Journal of Sports Medicine in February 2024. Dr. Jeremy Schroeder serves as the series host. Dr. Langenberg is a member of the Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2024, as selected for the 2025 AMSSM Annual Meeting. Platelet-Rich Plasma Versus Alternative Injections for Osteoarthritis of the Knee: A Systematic Review and Statistical Fragility Index-Based Meta-analysis of Randomized Controlled Trials: https://journals.sagepub.com/doi/10.1177/03635465231224463

Send us a textDo Heterogeneous Treatment Effects Exist?For the last 50 years, we've designed cars to be safe...For the 50th-percentile male.Well, that's actually not 100% correct.According to Stanford's report, we introduced "female" crash test dummies in the 1960s, but...They were just scaled-down versions of male dummies and...Represented the 5th percentile of females in terms of body size and mass (aka the smallest 5% of women in the general population).These dummies also did not take into account female-typical injury tolerance, biomechanics, spinal alignment, and more.But...Does it matter for actual safety?In the episode, we cover:- Do heterogeneous treatment effects (different effects in different contexts) exist?- If so, can we actually detect them?- Is it more ethical to look for heterogeneous treatment effects or rather look at global averages?Video version available on the Youtube: https://youtu.be/V801RQTBpp4Recorded on Nov 12, 2025 in Malaga, Spain.------------------------------------------------------------------------------------------------------About RichardProfessor Richard Hahn, PhD, is a professor of statistics at Arizona State University (ASU). He develops novel statistical methods for analyzing data arising from the social sciences, including psychology, economics, education, and business. His current focus revolves around causal inference using regression tree models, as well as foundational issues in Bayesian statistics.Connect with Richard:- Richard on LinkedIn: https://www.linkedin.com/in/richard-hahn-a1096050/About StephenStephen Senn, PhD, is a statistician and consultant who specializes in drug development clinical trials. He is a former Group Head at Ciba-Geigy and has taught at the University of Glasgow and University College London (UCL). He is the author of "Statistical Issues in Drug Development," "Crossover Trials in Clinical Research," and "Dicing with Death."Connect with Stephen:- Stephen on LinkedIn: Support the showCausal Bandits PodcastCausal AI || Causal Machine Learning || Causal Inference & DiscoveryWeb: https://causalbanditspodcast.comConnect on LinkedIn: https://www.linkedin.com/in/aleksandermolak/Join Causal Python Weekly: https://causalpython.io The Causal Book: https://amzn.to/3QhsRz4

Dr. Peter Rippey covers the No. 9 article of 2024, titled “Platelet-Rich Plasma Has Better Results for Long-term Functional Improvement and Pain Relief for Lateral Epicondylitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials,” which was originally published in The American Journal of Sports Medicine in February 2024. Dr. Jeremy Schroeder serves as the series host. Dr. Rippey is a member of the Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2024, as selected for the 2025 AMSSM Annual Meeting. Platelet-Rich Plasma Has Better Results for Long-term Functional Improvement and Pain Relief for Lateral Epicondylitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials: https://journals.sagepub.com/doi/10.1177/03635465231213087

This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39   Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al. 06:23   Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al. 11:17   Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al. 15:35   David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D. 17:27   William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research" by Roger S. McIntyre, M.D., F.R.C.P.C., et al. 24:04   Daniel S. Pine, M.D., discusses "Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial" by Carlos M. Grilo, Ph.D., et al. 26:06   Carolyn Rodriguez, M.D., Ph.D., discusses "Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders" by Emily R. Stern, Ph.D., et al. 30:26   Sean T. Lynch, M.D., discusses "From Medical Practice to Mass Incarceration: A Historical Analysis of Racial and Ethnic Targeting in U.S. Drug Policy" by Rathisha Pathmathasan, D.O., et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Drs. Jan Vojacek, a cardiac surgeon in the department of cardiac surgery at University Hospital Hradec Kralove, Czech Republic, and president of the Czech Society for Cardiovascular Surgery, and Maral Ouzounian, cardiac surgeon and head of the division of cardiac surgery at the Peter Munk Cardiac Center, Toronto, Canada, and president of the Canadian Society of Cardiac Surgeons, about the EACTS expert consensus statement on the Ross procedure in adult patients. Chapters 00:00 Intro 02:21 JANS 1, ARISE III Stent Graft Enrollment 04:25 JANS 2, Mech vs Biopros Valves in Hemodialysis 07:37 JANS 3, Surgical Sealants After Pulm Resection 09:54 JANS 4, Constrictive Pericarditis Procedures 12:45 Video 1, VATS CO2 Insufflation Technique 14:03 Third Place, Ascending Aortic Stenting Repair-Bridge 15:05 Second Place, Mustard & En Bloc Rotation of Tracts 16:49 First Place, Supracardiac Anomalous Pulm Ven Return 19:43 Drs. Vojacek & Ouzounian, Ross Procedure 42:02 Upcoming Events 42:21 Instructional Video Competition 42:49 Career Center They discussed the task force and process of getting this statement published, as well as important elements of the guidelines. Additionally, they addressed the significance of shared decision-making with patients, survival rates following the Ross procedure, and overall quality of life. They also compared the Ross procedure to mechanical and biological aortic valve replacements. They explored various surgical techniques related to the Ross procedure, including the native inclusion technique and the prosthetic inclusion technique, emphasizing the importance of technical details, patient selection, and intraoperative management. Furthermore, they discussed the Ross centers of excellence and how to start them.   Joel also highlights recent JANS articles on the ARISE III trial of gore ascending stent graft begins enrollment, mechanical vs bioprosthetic heart valves in hemodialysis patients, an individual patient data meta-analysis of randomized controlled trials on the clinical efficacy of surgical sealants after pulmonary resection, and radical pericardiectomy and use of cardiopulmonary bypass for constrictive pericarditis.  In addition, Joel explores a new approach for thymic pathologies, robotic-assisted repair of supracardiac total anomalous pulmonary venous return, and combined Mustard and en bloc rotation of the outflow tracts. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) ARISE III Trial of Gore Ascending Stent Graft Begins Enrollment  2.) Mechanical Versus Bioprosthetic Heart Valves in Hemodialysis Patients  3.) Clinical Efficacy of Surgical Sealants After Pulmonary Resection: An Individual Patient Data Meta-Analysis of Randomized Controlled Trials  4.) Radical Pericardiectomy and Use of Cardiopulmonary Bypass for Constrictive Pericarditis  CTSNet Content Mentioned  1.) A New Approach for Thymic Pathologies: VATS CO₂ Insufflation Technique  2.) Robotic-Assisted Repair of Supracardiac Total Anomalous Pulmonary Venous Return   3.) Combined Mustard and En Bloc Rotation of the Outflow Tracts   Other Items Mentioned  1.) EACTS Expert Consensus Statement on the Ross Procedure in Adult Patients   2.) Winners of the 2025 CTSNet Resident Video Competition  3.) Instructional Video Competition   4.) Career Center   5.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

This week, please join author Robert Lookstein and Associate Editor Joshua Beckman as they discuss the article "Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/10.1161/podcast.20260105.594056

“Too far, too fast?”In this sixth episode, Sarah Harrison, Director of the MHPSS Hub, and Dan Amias, Senior Innovation Learning Adviser at Elrha, speaks with Mercy Githara, MHPSS Manager at the Kenya Red Cross Society, and Anne de Graaf, Technical Officer at the World Health Organization (WHO) about two chatbots: STARS, a non-AI chatbot developed by WHO, and Chat Care, an AI chatbot being deployed in Kenya by the Red Cross.Key resources for practitioners:Kenya Red Cross Society: Chat Care, AI Powered Mental Health Chatbot  WHO: Doing What Matters in Times of Stress evidence based self-help guide WHO: STARS chatbot for more information contact psych_interventions@who.int Red Cross Digital MHPSS pledge: Leveraging and facilitating technology-empowered pathways  MHPSS Hub resources on Suicide prevention:Find infographics, videos, podcasts, guides and tools on suicide prevention Read more about the research:STARS chatbot (non-AI): de Graaff A.M, et al. Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial JMIR Ment Health  Keyan, D., et al.  The development of a World Health Organization transdiagnostic chatbot intervention for distressed adolescents and young adults.  Akhtar, A., et al. Scalable Technology for Adolescents and Youth to Reduce Stress in the Treatment of Common Mental Disorders in Jordan: Protocol for a Randomized Controlled Trial. Karim Chatbot: Madianou, M. Nonhuman humanitarianism: when “AI for good” can be harmful. Information, Communication & SocietyTorous, J. et al. Assessing generative artificial intelligence for mental health, The Lancet.Spencer SW, Masboungi C. Enabling access or automating empathy? Using chatbots to support GBV survivors in conflicts and humanitarian emergencies, International Review of the Red Cross. Developing digital MHPSS resources:Reach out to the MHPSS Hub: mhpsshub@rodekors.dk or Elrha: info@elrha.org for collaboration on developing digital MHPSS approaches.Evidence from the Frontline: Mental Health in Crisis-Affected Contexts is a six-episode mini-series produced in collaboration between the MHPSS Hub and Elrha, designed for practitioners working in humanitarian and crisis contexts, the series highlights impactful interventions and practical insights from experts in the field. 

Nutrient Deficiencies and Their Link to Alzheimer's Disease and Diabetes Risk in Night Owls: Nutritionist Leyla Muedin discusses research findings linking nutrient deficiencies to Alzheimer's disease and how diet and supplementation can play a crucial role in prevention. She highlights the importance of antioxidants like lutein, zeaxanthin, and lycopene for brain health and their potential to reduce Alzheimer's risk. Leyla also delves into the connection between evening chronotypes ('night owls') and an increased risk of diabetes, emphasizing the role of lifestyle factors and offering suggestions for healthier sleep habits. She encourages listeners to maintain a diet rich in carotenoids for better cognition and eye health, and to adjust sleeping patterns for overall well-being.

Results from STORM-PE - Randomized Controlled Trial

Drs Joseph Mikhael and Sigurdur Y. Kristinsson discuss whether it is time to screen for multiple myeloma and what we can learn from the iStopMM study. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002717. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Multiple Myeloma https://emedicine.medscape.com/article/204369-overview Screening in Multiple Myeloma and Its Precursors: Are We There Yet? https://pubmed.ncbi.nlm.nih.gov/38175579/ Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM): A Population-Based Screening Study for Monoclonal Gammopathy of Undetermined Significance and Randomized Controlled Trial of Follow-Up Strategies https://pubmed.ncbi.nlm.nih.gov/34001889/ Identifying Associations Between Race and Gender in the Incidence and Mortality of Patients With Multiple Myeloma https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.e20052 Revisiting Wilson and Jungner in the Genomic Age: A Review of Screening Criteria Over the Past 40 Years https://pubmed.ncbi.nlm.nih.gov/18438522/ International Myeloma Foundation https://www.myeloma.org/ Prevalence of Monoclonal Gammopathy of Undetermined Significance https://pubmed.ncbi.nlm.nih.gov/16571879/ Monoclonal Gammopathy of Undetermined Significance https://www.ncbi.nlm.nih.gov/books/NBK507880/ Prevalence and Risk of Progression of Light-Chain Monoclonal Gammopathy of Undetermined Significance: A Retrospective Population-Based Cohort Study https://pubmed.ncbi.nlm.nih.gov/20472173/ Mode of Progression in Smoldering Multiple Myeloma: A Study of 406 Patients https://pubmed.ncbi.nlm.nih.gov/38228628/ Observation or Treatment for Smoldering Multiple Myeloma? A Systematic Review and Meta-Analysis of Randomized Controlled Studies https://pubmed.ncbi.nlm.nih.gov/40419473/

Regional anesthesia, typically with a spinal or epidural, haslong been favored for cesarean births due in part to concerns about the effects that general anesthesia (GA) may have on newborns at delivery. However, data has shown that up to 1 in 6 women may experience pain with a “topped-off”labor epidural, during the cesarean. A new publication in the journal Anesthesia is now being interpreted as implying that general anesthesia may be a valid alternative electively. Is that what this new study found? Has GA been linked to postpartum depression? What about later child neurodevelopmental delays? This is a fascinating topic…Listen in for details. 1.     Langer, Sarah M.D.1; Lim, Grace M.D., M.Sc.2;Qiu, Yue M.D.3; Biaesch, Jingyuan D.O.4; Neuman, Mark D. M.D., M.Sc.5. NeonatalOutcomes with Regional versus General Anesthesia for Cesarean Delivery: AMeta-analysis of Randomized Controlled Trials. Anesthesiology():10.1097/ALN.0000000000005785, November 12, 2025. | DOI:10.1097/ALN.00000000000057852.     Guglielminotti J, Monk C, Russell MT, Li G.Association of General Anesthesia for Cesarean Delivery with PostpartumDepression and Suicidality. Anesth Analg. 2025 Sep 1;141(3):618-628. doi:10.1213/ANE.0000000000007314. Epub 2024 Dec 4. PMID: 39630595; PMCID:PMC12134152.3.     Chen, YC., Liang, FW., Tan, PH. et al.Association between general anesthesia for cesarean delivery and subsequentdevelopmental disorders in children: a nationwide retrospective cohort study.BMC Med 23, 119 (2025). https://doi.org/10.1186/s12916-025-03886-64.     https://www.pennmedicine.org/news/new-study-challenges-fears-about-general-anesthesia-during-c-section

The US has no shortage of lidocaine patch television commercials. Topical lidocaine has a role for local, topical, minor aches and pains. What about lidocaine patches for post-op cesarean section pain? Is there data for that? A brand-new meta-analysis in AJOG-MFM (Nov 13, 2025) looks at this option. However, there has been 3 prior reviews on the same topic from 2019, 2022, and 2023. Do they all arrive at the same result? Listen in for details!1.     Smoker J, Cohen A, Rasouli MR, Schwenk ES. TransdermalLidocaine for Perioperative Pain: A Systematic Review of the Literature. Current Pain and Headache Reports.2019;23(12):89. doi:10.1007/s11916-019-0830-9.2.     Koo CH, Kim J, Na HS, Ryu JH, Shin HJ. TheEffect of Lidocaine Patch for Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Anesthesia. 2022;81:110918.doi:10.1016/j.jclinane.2022.110918.3.     Wu X, Wei X, Jiang L, et al. Is Lidocaine PatchBeneficial for Postoperative Pain?: A Meta-Analysis of Randomized Clinical Trials. The Clinical Journal of Pain. 2023;39(9):484-490. doi:10.1097/AJP.00000000000011354.     Parisi, Nadia et al.Lidocaine patches aftercesarean delivery: a meta-analysis of randomized controlled trials. American Journal of Obstetrics & Gynecology MFM, Volume 0, Issue 0, 101832

Send us a Text Message (please include your email so we can respond!)Episode 77! We will start on ESICM coverage next episode. In this episode we talk about WFIT or "A Randomized Controlled Trial of a Post-ICU Telehealth Care Model" by Bakhru et al published in the blue journal September 2025! A long discussion but a good one!WFIT: https://pubmed.ncbi.nlm.nih.gov/40532205/Editorial: https://pubmed.ncbi.nlm.nih.gov/40700738/ICU Recovery Pilot: https://pubmed.ncbi.nlm.nih.gov/31385881/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

PULSE Randomized Controlled Trial

Take a sneak peek at this month's Fertility and Sterility! Articles discussed this month are:   (03:03) A Randomized Controlled Trial of Counseling and Educational methods on Preimplantation Genetic Testing for Aneuploidy (PGT-A) for in vitro fertilization (IVF) patients (14:02) Healthy euploid dizygotic twin birth after transfer of non-mosaic aneuploid embryos (25:05) Validity of completely omitting endocrine and ultrasound monitoring in hormone replacement therapy protocols for frozen embryo transfer in good-prognosis patients undergoing single blastocyst transfer (38:52) Cost-effectiveness of single euploid frozen embryo transfer in a true natural versus a hormonal replacement cycle (44:29) Modified Versions of Natural Frozen Embryo Transfers Do Not Impact Live Births (55:28) Soy consumption and the risk of laparoscopically confirmed endometriosis in a prospective cohort study (01:02:42) Optimizing In Vitro Maturation Outcomes of Oocytes Following Gonadotropin Priming in Premenarcheal Girls Undergoing Ovarian Tissue Cryopreservation View the November 2025, Volume 124 Issue 5 of Fertility and Sterility at https://www.fertstert.org/issue/S0015-0282(25)X0012-1 View Fertility and Sterility at https://www.fertstert.org/

Is mindfulness just fluffy nonsense?! In this episode of 'Getting Real with Mindfulness', hosts Claire and Victoria take on one of the most common misconceptions about mindfulness - that it's soft, indulgent, or lacking substance. Through personal stories, practical examples, and a touch of neuroscience, they explore how mindfulness is far from fluffy. It's gritty, challenging, and surprisingly practical. From mindful colouring to fierce compassion, they unpack what mindfulness really is and what it isn't. Whether you're a curious beginner, a trained teacher, or somewhere in between, this episode offers a fresh perspective on how mindfulness builds agency, supports emotional resilience, and helps us respond, rather than habitually react, to life.

Cautionary tales from carnitine and arginine complicate the taurine supplementation question.

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning speaks with Dr. Marc Pelletier, division chief of cardiac surgery for the Department of Surgery at Yale School of Medicine, about patient blood management. Chapters 00:00 Intro 01:45 EACTS 2025 07:19 JANS 1, HVD Management Guidelines 16:26 JANS 2, Low-Risk AVR Evidence 19:21 JANS 3, Warden Procedure Selection 20:36 JANS 4, Primary Repair of CAT 21:48 JANS 5, NEWTON-CABG Cardiolink-5 23:20 Video 1, Acute Aortic Syndrome 24:54 Video 2, Redo TVR Under Bypass 27:13 Video 3, Giant Tension Bulla 28:47 Dr. Pelletier Interview 34:25 Outro They delve into the Society of Thoracic Surgeons (STS) guidelines on patient blood management, along with key tips. They also explore preoperative optimization, provide an example, and discuss cell savers and reducing dead space during surgery. Additionally, they touch on postoperative transfusion and the importance of performing meticulous surgery.  Joel also highlights recent JANS articles on the 2025 ESC/EACTS guidelines for the management of valvular heart disease, low-risk aortic valve replacement at the crossroads of evidence, ideal age and weight for the Warden procedure in patients with partial anomalous pulmonary venous return, a systematic meta-analysis of short- and long-term outcomes of the primary repair of common arterial trunk, and an international, randomized, double-blind, placebo-controlled trial on the effect of Evolocumab on saphenous vein graft patency after coronary artery bypass surgery.  In addition, Joel explores the surgical treatment of acute aortic syndrome, a redo tricuspid valve replacement technique under right heart bypass for a previously repaired tricuspid valve, and thoracoscopic resection of a giant tension bulla. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) 2025 ESC/EACTS Guidelines for the Management of Valvular Heart Disease: Developed by the Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)   2.) Low-Risk Aortic Valve Replacement at the Crossroads of Evidence  3.) Is There an Ideal Age or Weight for the Warden Procedure in Patients With Partial Anomalous Pulmonary Venous Return?  4.) Primary Repair of Common Arterial Trunk: A Systematic Meta-Analysis of Short- and Long-Term Outcomes  5.) Effect of Evolocumab on Saphenous Vein Graft Patency After Coronary Artery Bypass Surgery (NEWTON-CABG CardioLink-5): An International, Randomized, Double-Blind, Placebo-Controlled Trial  CTSNet Content Mentioned  1.) Surgical Treatment of Acute Aortic Syndrome   2.) Redo Tricuspid Valve Replacement Technique Under Right Heart Bypass for a Previously Repaired Tricuspid Valve   3.) Thoracoscopic Resection of a Giant Tension Bulla   Other Items Mentioned  1.) STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management  2.) Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials  3.) Perfecting TAVR Removal | Skills Sharpening With Vince Gaudiani  4.) Career Center   5.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

AEM Podcast host Ken Milne, MD, and guest skeptic Lauren Westafer, DO, MPH, MS, interview lead author Karalynn Otterness, MD. Learn more in the accompanying Hot Off the Press article available in The Skeptics' Guide to Emergency Medicine.

Commentary by Dr.  Jian'an Wang.

Date: October 3, 2025 Reference: Doheim et al. Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke. Neurology 2025 Guest Skeptic: Dr. Casey Parker is a Rural Generalist, Evidence-based medicine enthusiast and Ultrasound Nerd. This episode was recorded live, in beautiful Broome, Australia, at the Spring Seminar on Emergency […] The post SGEM#488: It's Just a Minor Stroke – Should We Still Lyse? first appeared on The Skeptics Guide to Emergency Medicine.

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Marilyn N. Bulloch, PharmD, BCPS, FCCM, welcomes Matheus Bannach, MD, of Urgency Hospital of Goyes in the Eruseo-Dorne Cancer Hospital in Brazil. They discuss Dr. Bannach's article, “Transfusion Practices in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials,” published in the April 2025 issue of Critical Care Medicine. The study compared liberal and restrictive strategies for patients with traumatic brain injury (TBI). They found that a liberal transfusion strategy results in better neurologic outcomes than a restrictive strategy. Drs. Bulloch and Bannach discuss the importance of optimizing transfusion thresholds, the risks and benefits of blood transfusion for critically ill patients, and the limited supply of donated blood. The conversation also covers study methodology. Dr. Bannach explains the choice of main end point for the study, the process of selecting articles to include, and the rigorous peer review process. Listeners will find guidance for optimizing blood transfusion in patients with TBI, as well as key insights into review methodology. More discussion of this article can be found in the April 2025 Critical Content video. Resources referenced in this episode: Transfusion Practices in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (Larcipretti ALL, et al. Crit Care Med. 2025;53:e963-e972).

Show Summary:You are in for a treat! Do you have someone in your life that is interested in video games or game development? Claire talks with Aaron Thibault, the director of The LIVE Lab which is a research lab at Texas A&M University in the College of Performance, Visualization and Fine Arts where students learn to create interactive learning experiences while getting real industry experience. Hear his story along with the impact that game-based learning can have on learning as well as some ways you as a teacher can bring LIVE Lab projects to your classroom.About Aaron Thibault, LIVE Lab Director: Aaron Thibault is a game developer, educator and researcher who focuses on the innovation of game-based technologies that support learning and deep representations of people, environments and complex interactive scenarios. He was a key leader for the mega-franchise “Borderlands,” developed retention techniques and story pipelines for the first massive multiplayer game “Ultima Online,” and created the Digital Warrior game-based learning platform for the US Army as part of a joint TAMU-UT Austin “UXXI” digital transformation initiative. He organized and advised foundational research at his Digital Media CoLab including rtNEAT, a breakthrough real-time evolutionary neural network technique invented by Ken Stanley and an example of a core research invention that can only occur with support of a lab-based game development team. Aaron also helped start and managed the world's first graduate degree program for games, The Guildhall at SMU, and is an ACM SIGGRAPH Pioneer and former IEEE virtual reality program chair.About Texas A&M's LIVE Lab: The LIVE Lab is a research lab at Texas A&M University in the College of Performance, Visualization and Fine Arts where students learn to create interactive learning experiences while getting real industry experience. With the help of subject matter experts and instructional designers, students collaborate to make high-quality digital learning experiences, touching on every aspect of professional development including design, concept art, 3D modeling, development and management.Links from the Show:Related The STEM Space Podcast Episodes 68. Game Based Learning with André Thomas110. How to Implement Game-Based Learning ft. André ThomasVivify STEM Blog Posts Best Free AI Tools for EducatorsHow to Teach STEM Through A Story10 Must Have STEM ToolsVivify STEM LessonsIntro to Coding STEM ActivityTechnology Choice Boards FREE! - Using Geometry to Build a Safe Shelter!Other STEM ResourcesAaron Thibault | LinkedInTexas A&M LIVE LabA&M-developed calculus video game helps students pass, pursue STEM careersVariant: Limits Educational Trailer (YouTube)Variant: Limits (game)Train gamePrisms gameStudy: Learning Exponential Functions With Immersive Virtual Reality: Outcomes of a Randomized Controlled Trial as Part of the Prisms NSF SBIR Phase II ProjectThe Stanley Parable gameCortopia and Beyond Frames Wands AlliancesQuick TipsTHE STEM SPACE SHOWNOTESTHE STEM SPACE FACEBOOK GROUPVIVIFY INSTAGRAMVIVIFY FACEBOOKVIVIFY XVIVIFY TIKTOKVIVIFY YOUTUBE

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-451 Overview: The obesity epidemic has fueled a demand for weight loss medications. Trials have directly compared medications—specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—with a recent study doing just that. Tune in as we explore the evidence comparing semaglutide and tirzepatide for weight loss outcomes up to 1 year. Episode resource links: Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. 2024;184(9):1056-1064.  Moiz A, Filion KB, Toutounchi H, et al. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials. Ann Intern Med. 2025;178(2):199-217.  Wen J, Syed B, Nadora D, et al. Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies. Endocrinol Diabetes Metab. 2025;8(3):e70045.  Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-451 Overview: The obesity epidemic has fueled a demand for weight loss medications. Trials have directly compared medications—specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs)—with a recent study doing just that. Tune in as we explore the evidence comparing semaglutide and tirzepatide for weight loss outcomes up to 1 year. Episode resource links: Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, et al. Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity. JAMA Intern Med. 2024;184(9):1056-1064.  Moiz A, Filion KB, Toutounchi H, et al. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials. Ann Intern Med. 2025;178(2):199-217.  Wen J, Syed B, Nadora D, et al. Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies. Endocrinol Diabetes Metab. 2025;8(3):e70045.  Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

In this episode of the RWS Clinician's Corner, Margaret Floyd Barry takes us behind the scenes into the dynamic world of research and curriculum development in the functional health space. Margaret sits down with two of Restorative Wellness Solutions' powerhouse instructors, Ellen Lovelace and Paige Reagan, for a candid conversation about the challenges, surprises, and daily realities of translating emerging science into practical, safe, and effective tools for clinicians.   In this interview, we discuss:     -Specific ways that Ellen & Paige demonstrate curriculum leadership and research support for RWS   -How to respond to new studies or challenges to existing curriculum    -How to decide which sources to trust   -How to evaluate clinical research (red & green flags)   -Addressing research limitations and gaps    -Using research tools and AI in gathering evidence   The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/    Connect with Ellen:  Website: www.abalancedtable.net Facebook: www.facebook.com/abalancedtable Instagram: www.instagram.com/abalancedtable   Connect with Paige: Website: www.naturallynourishedwellness.com Instagram: www.instagram.com/paigereaganntp   Timestamps: 00:00 From Russian Studies to Health Advocacy 07:56 Curriculum Accuracy and Depth Focus 12:57 Using AI for Study Validation 19:20 Evaluating Research Article Credibility 25:24 Animal Study Relevance and Limitations 28:03 "Pediatric Research Gaps in Drug Trials" 33:55 "Teaching Deepens Understanding" 41:17 Questioning AI for Balanced Answers 44:47 Effective Research Strategies and AI Limitations 52:04 Verify Before Believing Headlines 55:52 "Unpaywall: Access Free Academic Papers" 01:00:33 "The Clinician's Corner Podcast" Speaker bios: Ellen Lovelace, Lead Instructor & Curriculum Development Master RHP, MPH, FNTP, Board Certified in Holistic Nutrition® Ellen (she/her) has been actively working to educate and improve the public's health for almost 20 years. Ellen received her Masters in Public Health from The George Washington University, and went on to run everything from tuberculosis prevention programs in Russia to dental health education programs along the Texas/Mexico border. She was also the founding Executive Director of the women's health program at Stanford University. When Ellen became drawn to a more holistic model, she received her certifications as a Nutritional Therapy Consultant and a Master Restorative Health Practitioner. She is the owner of A Balanced Table Nutritional Therapy in San Jose, CA, her private functional nutrition practice. Ellen focuses on cutting through the confusion and nutrition “noise,” digging to the roots of clients' dysfunction, and figuring out the best way for them to eat, drink, and thrive. She uses the IRH functional analysis tools daily, and is excited to share her passion for these methods. Ellen believes that only by focusing on root causes, combined with whole foods nutrition, can true wellness be achieved. Ellen is also a passionate animal lover who volunteers at a wildlife rescue facility, and can often be found smelling of skunk while covered in Mastiff drool.    Paige Reagan, Instructor and Research Master RHP, FNTP Paige has spent most of her career working in Research and Development in the areas of clinical research, regulatory affairs, and medical writing. She has a wide range of experience in the therapeutic areas of cardiovascular health, pulmonary arterial hypertension, diabetes, bone health, osteoarthritis/rheumatoid arthritis, and urology, among others. Her work has contributed to numerous regulatory approvals as well as publications in major medical journals such as the New England Journal of Medicine, Lancet, Circulation, and American Heart Journal. Paige has since earned certifications as a Functional Nutritional Therapy Practitioner and Master Restorative Health Practitioner. She is owner of Naturally Nourished Wellness, a small practice specializing in gut health and the downstream effects of poor digestion. She strives to find balance between the holistic and mainstream approaches and aims to provide her clients with the best of both worlds, using her critical thinking skills from years in research combined with objective laboratory testing and her passion for the restorative power of whole foods and simple lifestyles. She spends her free time exploring the outdoors with her family, swinging kettlebells, and creating baked goods with healthier ingredients.   Keywords: functional nutrition, public health, research process, curriculum development, clinical research, regulatory affairs, medical writing, gastrointestinal healing, lab testing, food sensitivities, evidence-based practice, study design, randomized controlled trials, observational studies, animal studies, peer review, PubMed, Google Scholar, AI tools in research, ChatGPT, consensus, study citations, clinical anecdote, sample size, funding bias, meta-analysis, systematic reviews, biostatistics, clinical protocols, dietary supplements   Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

A key part of symptom management, agitation management, and humanizing care is communication. Throughout the podcast, we have discussed non-verbal communication during mechanical ventilation. ....but what about non-invasive ventilation? How does the inability to communicate impact care, patient experience, and outcomes for patient on BIPAP? Dr. Ian Wong shares with us his research and innovation that is transforming communication during non-invasive ventilation. Randomized Controlled Trial of a Novel Communication Device Assessed During Noninvasive Ventilation Therapy - PubMedAtaia Medical – Empowering Patients with the Freedom to Speakwww.DaytonICUConsulting.com

On Episode 55 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2025 issue of Stroke: “Anticoagulation Timing in Acute Stroke With Atrial Fibrillation According to Chronic Kidney Disease: The OPTIMAS Trial” and “Risk of Intracranial Hemorrhage With Apixaban Versus Aspirin Therapy: A Meta-Analysis of Randomized Controlled Trials.” She also interviews Dr. Stephen Ryan and Prof. Anne Aamodt about the Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS), presented in May at the European Stroke Organisation Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250815.784085

Nutritionist Leyla Muedin focuses on the impact of various exercise interventions on insomnia, based on a recent study published in the British Medical Journal (BMJ). The study compares exercise interventions like yoga, Tai Chi, and jogging to improve both subjective and objective sleep outcomes for insomnia patients. Additional discussion covers the benefits of exercise on neuroplasticity and sleep architecture, while also addressing alternative treatments such as hypnotics and cognitive behavioral therapy (CBT). Leyla shares personal insights and practical advice for incorporating exercise into daily routines for better sleep.

In this conversation, Dr. Elizabeth Klodas, a preventive cardiologist and founder of Step One Foods, discusses the critical role of nutrition in managing heart disease and the challenges faced in integrating dietary changes into medical practice. She shares her journey from traditional medicine to creating a food company aimed at reducing reliance on medications through nutrition. The discussion highlights the importance of randomized controlled trials in validating the effectiveness of food-based interventions, the impact of pharmaceuticals on healthcare, and the need for a shift in consumer perceptions towards whole food ingredients. Dr. Klodas emphasizes the potential for a healthier future where cardiologists are less needed due to preventive measures and lifestyle changes.Takeaways:Nutrition is often overlooked in favor of pharmaceuticals in healthcare.Patients are rarely asked about their diet by healthcare providers.Changing dietary habits can lead to significant health improvements.Pharmaceuticals are easier to prescribe than dietary changes.There is a lack of nutrition education in medical training.Step One Foods aims to fill nutritional gaps in patients' diets.Randomized controlled trials can validate the effectiveness of food products.Consumer perceptions of health foods can be influenced by marketing.The food industry often prioritizes cost over nutrition.A better world would mean fewer cardiologists needed due to preventive health measures.Sound bites:“There is very little to no nutrition education for physicians. As I look back on this I consider this educational malpractice.”“All the medical evidence of what we should be doing is very heavily pharma biased, because guidelines are based on randomized control clinical trials.”“So there's loads of reasons why nutrition is not used in clinical care the way it should be. None of that is an excuse though, because it works and it's so vital.”“What if I asked you to like eat this food twice a day and I otherwise left you alone? What started happening is people calling and saying, hey, my cholesterol dropped 39 points. Then I'm like, okay, we're gonna subject our products to a randomized control trial. Let's see. Let's prove it. Does this actually work?”“If I reduce, LDL, the bad cholesterol across the US population by an average of 9%, I will finally dethrone heart disease as our number one killer.”“In that trial, we replicated what people were calling in with our highest LDL reduction was close to 40 % in 30 days. That's a medication level cholesterol reduction. And we did that with food, without turning people's lives upside down.”“It's not just the nutrient of interest that's important. It's the delivery vehicle. You can stuff a bunch of fiber into a Twinkie. But in the end, you're still eating a Twinkie, right? Food and nutrition is complex.”“At Step One Foods I take the complexity out for people. I take whole food ingredients, each and every single one that has data behind it in terms health benefits, and put them in my foods.”“We are probably the most overfed and undernourished society in the history of our species.”“If you truly believe in your mission, you have to ignore all the no's.”Promo Offer:Code: BETTERWORLDLink: https://www.steponefoods.com/discount/BETTERWORLDOffer: 10% off first order for both one time and subscription orders. Offer can be stacked with the subscription discount to save 30% on their first order. Exclusions: Limited to one use per customer. Limited to a customer's first order and only applies to the first recurring order. Code must be entered at checkout for the discount to be applied. Links:Dr Elizabeth Klodas on LinkedIn - https://www.linkedin.com/in/eklodas/Step One Foods- https://www.steponefoods.com/Step One Foods on LinkedIn - https://www.linkedin.com/company/steponefoods/Step One Foods on Facebook - https://www.facebook.com/StepOneFoodsStep One Foods on Instagram - https://www.instagram.com/steponefoods/Step One Foods on YouTube - https://www.youtube.com/StepOneFoods…“Slay the Giant: The Power of Prevention in Defeating Heart Disease” book - https://www.steponefoods.com/products/slay-the-giant…Brands for a Better World Episode Archive - http://brandsforabetterworld.com/Brands for a Better World on LinkedIn - https://www.linkedin.com/company/brand-for-a-better-world/Modern Species - https://modernspecies.com/Modern Species on LinkedIn - https://www.linkedin.com/company/modern-species/Gage Mitchell on LinkedIn - https://www.linkedin.com/in/gagemitchell/…Print Magazine Design Podcasts - https://www.printmag.com/categories/printcast/…Heritage Radio Network - https://heritageradionetwork.org/Heritage Radio Network on LinkedIn - https://www.linkedin.com/company/heritage-radio-network/posts/Heritage Radio Network on Facebook - https://www.facebook.com/HeritageRadioNetworkHeritage Radio Network on X - https://x.com/Heritage_RadioHeritage Radio Network on Instagram - https://www.instagram.com/heritage_radio/Heritage Radio Network on Youtube - https://www.youtube.com/@heritage_radioChapters:03:00 Introduction to Preventive Cardiology and Nutrition05:58 The Shift from Nutrition to Medication in Healthcare08:45 The Role of Pharmaceuticals in Patient Care11:41 The Challenges of Nutrition Education in Medicine14:41 The Complexity of Food and Nutrition Science17:59 Step One Foods: A New Approach to Nutrition20:57 The Impact of Randomized Controlled Trials on Nutrition23:59 The Importance of Ingredient Quality in Food Products26:49 Pushback from the Medical and Food Industries29:52 The Insurance Industry's Role in Healthcare Costs32:52 Step One Foods: Product Overview and Benefits38:43 Introduction to Whole Foods and Health Claims40:56 The Importance of Real Ingredients42:56 Navigating Organic Ingredients and Supply Chain Challenges44:59 Stepwise Approach to Health and Nutrition48:58 Challenges in Scaling Food Production51:49 Milestones and Industry Changes56:55 Advice for Aspiring Food Entrepreneurs59:50 Personal Indulgences and Food Preferences01:03:00 Innovative Thinkers in Nutrition01:05:50 Vision for a Healthier WorldSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On Episode 54 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2025 issue of Stroke: “Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality” and “Effect of Argatroban Plus Dual Antiplatelet in Branch Atherosclerosis Disease: A Randomized Clinical Trial.” She also interviews Dr. Amrou Sarraj about the article “Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomized Controlled Trials.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250710.454589

Take a sneak peak at this month's Fertility & Sterility! Articles discussed this month are:   03:32 How Many Infants Have Been Born With the Help of Assisted Reproductive Technology? 11:33 Adding Short-Duration Gonadotropin-Releasing Hormone Antagonist and Gonadotropin to Natural Cycle Frozen Embryo Transfer Allowed Scheduling of Transfer Day Without Compromising Live Birth 24:42 Sublingual Progesterone Lozenges Are a Viable Alternative to Intramuscular Porgesterone-in-Oil for Programmed Frozen Embryo Transfer Cycles 33:08 Perinatal Outcomes of Progesterone in Natural Frozen-Thawed Embryo Transfer Pregnancies: Insights From 2 Randomized Controlled Trials 42:38 Cost Effectiveness Analysis of Uterus Transplantation vs. Gestational Carrier for Treatment of Absolute Uterine Factor Infertility in the United States AND Comparing Gestational Carrier with Uterine Transplantion in Uterine-Factor Infertility: A Cost-Effectiveness Analysis 01:03:28 Extended Intrauterine Balloon Stent Use to Prevent Adhesion Reformation After Hysteroscopic Adhesiolysis, A Randomized Trial View the July 2025 issue, Vol 124: 1-178 - https://www.fertstert.org/issue/S0015-0282(25)X0006-6 View Fertility and Sterility at https://www.fertstert.org/  

The Seed Oil Controversy: Unpacking Health Risks and Alternatives with Jonathan Rubin, CEO of the Seed Oil Free Alliance. The discussion focuses on the potential health hazards posed by seed oils, which have become ubiquitous in the American diet. They explore how these oils may be linked to chronic disease and obesity and compare this with the mainstream view that considers them harmless. Jonathan shares insights from his personal health journey and explains the mission and methodology of the Seed Oil Free Alliance, which aims to provide consumers with reliable information and certification for seed oil-free products. The episode also covers the historical context of seed oil consumption, the science behind omega-6 fatty acids, and practical alternatives for a healthier diet.

Dr. Hoffman continues his conversation with Jonathan Rubin, CEO of the Seed Oil Free Alliance.

Spring is the perfect time to shake up your routine. In this episode, Professor Tim Spector and Dr. Federica Amati reveal seven delicious, science-backed foods that help cool the flame of chronic inflammation. Whether you're dealing with bloating, aching joints, or low energy, this episode is packed with easy, gut-friendly tips to help you feel your best this season. Tim and Federica begin by explaining what inflammation really is and when it becomes a problem. Then, they'll introduce seven anti-inflammatory foods that are as powerful as they are delicious. From cruciferous vegetables to fermented surprises, these everyday ingredients can help you build a more resilient, healing diet.  Finally, they offer a roadmap for long-term change. Tim and Fed each share one small but powerful shift to reduce inflammation over four timelines - what you can do today, this week, this month, and throughout the year - to create habits that truly stick.