Podcasts about Genome

FOLLOW RICHARD Website: https://www.strangeplanet.ca YouTube: @strangeplanetradio Instagram: @richardsyrettstrangeplanet TikTok: @therealstrangeplanet EP. #1289 THE GENOME GRAB: How Government, Big Tech & Big Medicine Are Claiming Your Child's DNA Tonight on Strange Planet, we expose a quiet revolution unfolding in American medicine — one that could redefine parenthood, privacy, and human identity itself. The U.S. government, backed by Big Medicine, Big Tech, and Big Data, is laying the groundwork for mass newborn genome sequencing: decoding nearly every letter of a child's DNA at birth and storing it indefinitely. Attorney and child-welfare advocate Leah Wilson joins me to reveal how this program works, who profits, and why parents may soon lose control over their children's biological destiny. This isn't science fiction. It's happening now — and the stakes couldn't be higher. GUEST: Leah Wilson, JD, is an attorney, child-welfare advocate, and co-founder of Stand for Health Freedom, the organization currently suing the CDC in a landmark challenge to federal vaccination policy. She is one of America's most fearless voices exposing how genomic data is harvested, stored, and weaponized under the banners of “precision medicine” and “public health.” Wilson is also co-author of Reclaim Vitality, written with her husband, Dr. Nick Wilson, revealing how families can exit the machinery of conventional medicine. Her work uncovers a chilling reality: a global genetic arms race is already underway — and our children are on the front lines. WEBSITE: https://askdrwilson.libsyn.com BOOK: Reclaim Vitality: A Guide to Exit Conventional Medicine and Live Naturally SUPPORT OUR SPONSORS!!! FOUND – Smarter banking for your business Take back control of your business today. Open a Found account for FREE at Found dot com. That's F-O-U-N-D dot com. Found is a financial technology company, not a bank. Banking services are provided by Lead Bank, Member FDIC. Join the hundreds of thousands who've already streamlined their finances with Found. HIMS - Making Healthy and Happy Easy to Achieve Sexual Health, Hair Loss, Mental Health, Weight Management START YOUR FREE ONLINE VISIT TODAY - ⁠HIMS dot com slash STRANGE⁠ ⁠https://www.HIMS.com/strange⁠ MINT MOBILE Premium Wireless - $15 per month. No Stores. No Salespeople. JUST SAVINGS Ready to say yes to saying no? Make the switch at MINT MOBILE dot com slash STRANGEPLANET. That's MINT MOBILE dot com slash STRANGEPLANET BECOME A PREMIUM SUBSCRIBER!!!⁠ ⁠https://strangeplanet.supportingcast.fm⁠ Three monthly subscriptions to choose from. Commercial Free Listening, Bonus Episodes and a Subscription to my monthly newsletter, InnerSanctum. Visit ⁠https://strangeplanet.supportingcast.fm⁠ Use the discount code "Planet" to receive $5 OFF off any subscription. We and our partners use cookies to personalize your experience, to show you ads based on your interests, and for measurement and analytics purposes. By using our website and services, you agree to our use of cookies as described in our Cookie Policy. Learn more about your ad choices. Visit ⁠megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://strangeplanet.supportingcast.fm/

Osteosarcoma Webinar Series: Isidro Cortés-Ciriano will discuss his work studying how ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution.

Dr. Jason Vassy, is a primary care physician at the VA Boston Healthcare System. He leads the Genomes to Veterans Research Program, which focuses on bringing genomic tools into everyday Veteran care. His goal is help VA use genetic information in order to improve Veterans health, he emphasizes, “How can we use a Veteran's genetic makeup to help improve their healthcare?” he clarifies that while not all conditions require genetic testing, “in the areas where we know doctors should be using genetic testing… how do we make it easier for them?” This work shows how VA is staying ahead when it comes to health and technology.In Dr. Vassy's VA study on pharmacogenetics for depression, he found that Veterans who received DNA-guided medication choices fared better, stating, “Patients that got that kind of testing were more likely to have a medication that was a better match for their DNA and had lower rates of depressive symptoms.” His team also used data from the Million Veteran Program (MVP) to identify Veterans with a genetic form of extremely high cholesterol, noting, “We reached back out… and got them connected to clinical genetic testing, increased surveillance, and treatment.” These actions helped Veterans and their families reduce their risk of early heart disease.In addition, Vassy leads the nationwide PROGRESS Study, which uses genetic risk to guide prostate cancer screening for men ages 55 to 70. Vetertans can enroll online and submit a saliva kit from home. “Prostate cancer is the most common cancer in men,” Vassy said, and genetic guidance may allow VA to detect dangerous cancers earlier while reducing harm from over-screening. He also stresses that VA protects genetic information with the strictest safeguards: “These data are password-protected, encrypted… only people with a right to access it can do so.”Looking ahead, Vassy believes genomic medicine will increasingly shape preventive care as technology advances and costs fall. He encourages Veterans to start by knowing their family history and talking with their providers about potential genetic risks, noting, “Genetics is just another tool in the toolbox for how to manage a concern you bring to your provider.” Veterans can explore opportunities to participate in ongoing research and learn more about genomic testing throughout VA's national programs.Resourceshttps://www.genomes2people.org/research/genomes2veterans/https://www.research.va.gov/mvp/https://www.progress-study.org/https://www.va.gov/washington-dc-health-care/programs/pharmacogenomics/https://www.va.gov/southern-nevada-health-care/stories/pharmacogenomics-and-how-the-va-is-improving-the-efficacy-of-medicine-through-dna/ https://www.research.va.gov/services/amp/precision_oncology.cfm 

Pat talks with philosopher Dr. Tim Pawl, author of Jesus and the Genome, about the theological and philosophical challenges raised by evolutionary biology and how Christians can think clearly about them. Jesus and the Genome: https://amzn.to/4il5Ys8 Tim on Substack: https://pawlineepistles.substack.com/  Pat on Substack: https://journalofabsolutetruth.substack.com/ 

The genome sequences of Neandertals and Denisovans have provided a wealth of new information about the origins, migrations, and interactions of ancient humans. These genomes have revealed that mixture between hominin groups was common: all modern humans outside Africa carry around 2% Neandertal DNA from a single major episode of Neandertal gene flow, while the ancestors of present-day Asians and Oceanians also met and mixed with multiple, genetically distinct Denisovan populations. Archaeological evidence suggests multiple dispersals of modern humans out of Africa, with early fossils identified in East and Southeast Asia over 50 thousand years ago. In contrast, genomic studies indicate that all present-day non-African populations descend primarily from a single dispersal after ~50 ka, though the migration routes of ancestral populations across Eurasia and Oceania remain unclear. Janet Kelso, professor at Max Planck Institute for Evolutionary Anthropology, shows how using the distribution of Neandertal and Denisovan ancestry in ancient and present-day modern humans can determine when, where and how often modern and archaic humans met and mixed. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 41192]

In his latest thriller LABYRINTH, author A.G. Riddle explores the impact of AI-generated virtual reality on future generations. Listeners will also find out why The Quill & The Quantum's new tagline brought tears to Gerry's eyes! Author info available at www.agriddle.com. A.G. Riddle spent ten years starting internet companies before retiring to pursue his true passion: writing fiction. His debut novel, The Atlantis Gene, is the first book in a trilogy (The Origin Mystery) that has sold over three million copies worldwide, has been translated into twenty-four languages, and is in development to be a major motion picture. His fourth novel, Departure, follows the survivors of a flight that takes off in 2015 and crash-lands in a changed world. HarperCollins published the novel in hardcover in the fall of 2015, and 20th Century Fox is developing it for a feature film. Released in 2017, his fifth novel, Pandemic, focuses on a team of researchers investigating an outbreak that could alter the human race. The sequel, Genome, concludes the two-book series. Released in 2019, his seventh novel, Winter World, depicts a group of scientists racing to stop a global ice age. It is the first book in The Long Winter Trilogy, which is now complete. Riddle grew up in Boiling Springs, North Carolina and graduated from UNC-Chapel Hill. During his sophomore year in college, he started his first company with a childhood friend. He currently lives in Raleigh, North Carolina with his wife, daughter, and an eccentric dog. No matter where he is, or what's going on, he tries his best to set aside time every day to answer emails and messages from readers. You can reach him at: ag@agriddle.com

In his latest thriller LABYRINTH, author A.G. Riddle explores the impact of AI-generated virtual reality on future generations. Listeners will also find out why The Quill & The Quantum's new tagline brought tears to Gerry's eyes! Author info available at www.agriddle.com. A.G. Riddle spent ten years starting internet companies before retiring to pursue his true passion: writing fiction. His debut novel, The Atlantis Gene, is the first book in a trilogy (The Origin Mystery) that has sold over three million copies worldwide, has been translated into twenty-four languages, and is in development to be a major motion picture. His fourth novel, Departure, follows the survivors of a flight that takes off in 2015 and crash-lands in a changed world. HarperCollins published the novel in hardcover in the fall of 2015, and 20th Century Fox is developing it for a feature film. Released in 2017, his fifth novel, Pandemic, focuses on a team of researchers investigating an outbreak that could alter the human race. The sequel, Genome, concludes the two-book series. Released in 2019, his seventh novel, Winter World, depicts a group of scientists racing to stop a global ice age. It is the first book in The Long Winter Trilogy, which is now complete. Riddle grew up in Boiling Springs, North Carolina and graduated from UNC-Chapel Hill. During his sophomore year in college, he started his first company with a childhood friend. He currently lives in Raleigh, North Carolina with his wife, daughter, and an eccentric dog. No matter where he is, or what's going on, he tries his best to set aside time every day to answer emails and messages from readers. You can reach him at: ag@agriddle.com

Code and Canvas: The Digital Art Genome - A Living Exhibit Showcasing the Evolution of Digital Art and the Artists Defining It. During Miami Art Week 2025 (December 2-7), Blackdove will present Code and Canvas: The Digital Art Genome, an exhibition that celebrates the world's premier digital artists and the new ways people experience art in the digital age. The showcase unites art, technology, and emotion, transforming every screen into a living canvas. Blackdove The Digital Art Genome The installation will feature immersive works across celebrated digital art categories by acclaimed motion and digital artists including Zach Lieberman, Yoshi Sodeoka, Alan Bolton, Jamie Scott, Jacopo di Cera, Kelly Boesch, Punkmetender, Moonwalker, and Annibale Siconolfi, with additional artists to be announced. Each artist brings a unique visual language that explores the intersection of technology, architecture, and contemporary art. Visitors will experience how motion art transcends traditional boundaries - flowing across Blackdove's Digital Canvas displays and integrated environments that harmonize with luxury living, hospitality, and architectural design. Both the artworks and the Digital Canvas displays featured in the exhibition will be available for purchase, offering collectors a seamless way to bring moving art into their own Spaces. "Blackdove extends the tradition of art into the digital age, honoring the gallery, the curator, and the collector, while transforming every screen into a living canvas," said Marc Billings, Founder and CEO of Blackdove. "At CONTEXT Miami, we're showing how Code and Canvas: The Digital Art Genome can transcend platforms and become part of daily life." The Exhibition: Code and Canvas: The Digital Art Genome At the heart of Code and Canvas: The Digital Art Genome is Blackdove's commitment to "inspiring moments that move us." The exhibit illustrates how digital art has evolved from screen-based novelty into an immersive ecosystem where collectors, artists, and designers converge to shape a new creative era. About Blackdove Blackdove is a curated digital art platform and premium digital canvas provider where every screen becomes a living canvas, a place where the world's most visionary artists are celebrated, where discovery feels effortless, and collecting becomes a daily expression of space. Through its streaming service, subscription tiers, and partnerships with leading display makers, including Samsung, LG, and BrightSign, Blackdove transforms homes, offices, galleries, and public spaces into immersive art experiences. Founded in Miami in 2015, Blackdove now connects artists, collectors, and integrators across 50+ countries through curated streaming, flexible ownership models, and innovative Integrations. As the world's curator of premier digital art, Blackdove unites art and technology to bring culture and motion into everyday environments, inspiring moments that move us. Discover. Collect. Share. Every screen becomes a living canvas. Event Details: Exhibit: Blackdove at CONTEXT Art Miami 2025 Dates: December 2-7, 2025 Location: One Herald Plaza, Miami, FL Web: www.blackdove.com See more breaking stories here.

Commentary by Dr. Jian'an Wang.

Episode 332 For only the second time, the genome of an ancient Denisovan has been sequenced - thanks to the discovery of a 200,000-year-old tooth found in a Siberian cave. This ancient member of the human family has long been a mystery, so this genome is being described as a bombshell moment, revealing an early stage of Denisovan history. We explore how this reshapes our understanding about the origins of our species. Some 95 per cent of us have a dormant virus, lurking in our bodies - waiting to strike when the moment's right. Epstein-Barr virus causes glandular fever - also known as mono or kissing disease - but only in a small number of people. Though new evidence is showing that even dormant viruses may still cause long term health problems. Formula E electric race cars may have surpassed their fossil fuel counterparts. From greater efficiency to faster acceleration, this is a big turning point for the sport - but they don't have the edge on F1 cars in all areas just yet. We find out where they're winning and where they're falling behind - and how this could translate to better electric road cars for us. And the legendary science writer Bill Bryson joins the team to discuss the process of revising his bestselling book A Short History of Nearly Everything. He explores some of the most fascinating (and surprising) facts he's had to update in the 20 years since the book came out. Chapters: (00:00) Intro (01:45) Second Denisovan genome sequenced (11:15) We all have dormant viruses that are causing diseases (18:37) Are Formula E cars faster than F1? (27:17) Bill Bryson on revising his bestselling book Hosted by Rowan Hooper and Penny Sarchet, with guests Bill Bryson and Alec Luhn. To read more about these stories, visit https://www.newscientist.com/ Check out the CoLab feature with DEEP at https://newscientist.com/deep  Shop our Black Friday sale at www.newscientist.com/sale Learn more about your ad choices. Visit megaphone.fm/adchoices

John Oakley hosts an extraordinary conversation with geneticist and archaeologist Dr. Turi King, who breaks down the science behind the recent genome sequencing of Adolf Hitler using a bloodstained relic from his Berlin bunker. From medical anomalies like Kallmann syndrome to the ethical limits of DNA in psychological profiling, King separates fact from speculation. The show also explores Toronto's performative civic acknowledgements—slavery, land, and beyond—with guests David Wills, VP at Media Profile, and National Post columnist Tristan Hopper, who challenges the rise of revisionist narratives in public ceremonies. A compelling mix of science, history, politics, and public discourse. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Epigenetics Podcast, we talked with Anders Sejr Hansen from MIT about his work on the impact of 3D genome structures on gene expression, the roles of proteins like CTCF and cohesin, and advanced techniques like Region Capture Micro-C for mapping genome organisation. Dr. Sejr Hansen introduces his research focusing on the relationship between three-dimensional genome structure and function, specifically how these structures can influence gene expression. He elaborates on the importance of transcription factors and the role of looping structures in gene regulation, emphasizing the implications of his work for understanding gene functionality in the context of both development and disease. The conversation then shifts to discussing loop extrusion and the factors affecting loop stability, primarily CTCF and cohesin. Dr. Sejr Hansen highlights the dynamics of these proteins' binding interactions and how their speeds challenge the notion of stable looping structures in the genome. With a keen interest in CTCF's role, he explains how the protein interacts with DNA and the mechanistic aspects of transcription factor movement, alluding to research findings that reveal that CTCF and cohesin tend to form clusters which may play vital roles in establishing chromatin structure. As the interview progresses, Dr. Sejr Hansen details his transition to leading his own lab at MIT, emphasizing the continuation of his earlier work while expanding into new methodologies for studying chromatin. He underscores the importance of understanding not just the static structures of DNA interactions, but the dynamic nature of these relationships and how they influence gene expression. His lab's recent focus has included using advanced imaging techniques to assess the dynamics of chromatin interactions more precisely. The discussion then touches on specific findings from Dr. Sejr Hansen's lab regarding the relationship between genome organization and double-strand break repair mechanisms. He emphasizes how the repair machinery can affect chromatin structure and underscores the essential role of cohesin in facilitating effective double-strand break repair by keeping broken DNA ends in proximity. He suggests that loop extrusion might help prevent genetic material from diffusing too far apart and improve the efficiency of repair. Dr. Sejr Hansen also discusses innovations in genome mapping techniques, particularly the development of Region Capture Micro-C, which facilitates deeper insights into the three-dimensional organization of the genome. This method allows researchers to achieve significantly higher resolution in their analyses compared to traditional 3D genomics techniques like Hi-C. He outlines the technical process and the implications of their findings, especially regarding enhancer-promoter interactions and the surprisingly promiscuous nature of these relationships. References Anders S Hansen, Iryna Pustova, Claudia Cattoglio, Robert Tjian, Xavier Darzacq (2017) CTCF and cohesin regulate chromatin loop stability with distinct dynamics eLife 6:e25776 https://doi.org/10.7554/eLife.25776 Claudia Cattoglio, Iryna Pustova, Nike Walther, Jaclyn J Ho, Merle Hantsche-Grininger, Carla J Inouye, M Julius Hossain, Gina M Dailey, Jan Ellenberg, Xavier Darzacq, Robert Tjian, Anders S Hansen (2019) Determining cellular CTCF and cohesin abundances to constrain 3D genome models eLife 8:e40164 https://doi.org/10.7554/eLife.40164 Goel, V.Y., Huseyin, M.K. & Hansen, A.S. Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments. Nat Genet 55, 1048–1056 (2023). https://doi.org/10.1038/s41588-023-01391-1 Related Episodes Biophysical Modeling of 3-D Genome Organization (Leonid Mirny) Unraveling Mechanisms of Chromosome Formation (Job Dekker) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Episode 331 This week sees the broadcast on Channel 4 in the UK of a documentary called Hitler's DNA: Blueprint of a dictator. Geneticists have managed to find a DNA sample from Adolf Hitler and have sequenced it and verified it, and now we have his genome. The big question is what does this really tell us – what can we tell from someone's genome?  In this special episode of the podcast, Rowan Hooper is joined by two of the lead figures on the documentary. Turi King is a geneticist at the University of Bath and is best known for the identification of the remains of Richard III, and Alex Kay is a historian of Nazi Germany based at Potsdam University in Germany.  Rowan also discusses the documentary with New Scientist reporter Michael Le Page. To read more about these stories, visit https://www.newscientist.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Kim E. Nichols leans on findings from the Pediatric Cancer Genome Project to discover the role genes and ancestry play in the development of cancer.

As the number of bird flu cases across the country rises, DEFRA has announced bird keepers across England must house all poultry and captive birds if they keep more than 50 birds. Avian influenza is just one of the animal disease threats raised in a new report by the House of Commons Public Accounts Committee. It says the government would not be ready for a serious national disease outbreak like BSE or foot and mouth because resources have been focused on tackling ongoing outbreaks of avian influenza and bluetongue.All week we're taking a closer look at the start of the farming process; seeds. Most farmers buy seeds of some kind whether it's growing a crop for us to eat, or grass seed for pasture, or wildflower mixes for pollinators. However growing crops to produce the seeds that farmers plant, is just as important. We visit a farmer in South Wales who's diversified and now supplies other farmers with wildflower and grass seed mixes.Plant scientists have mapped the genome of oats. Academics at the University of Aberystwyth say it will help plant breeders develop varieties better suited to cope with disease and climate change.Presenter = Anna Hill Producer = Rebecca Rooney

Commentary by Dr. Tong Liu.

In Episode 2 of this season, we explore the evolution of beauty (especially in birds) and the beauty of innovation, with guest Matt Ridley.Matt Ridley's books have sold over a million copies, been translated into 31 languages and won several awards. His books include The Red Queen, Genome, The Rational Optimist, The Evolution of Everything, How Innovation Works, and Viral: the search for the origin of covid-19 (co-authored with Alina Chan). His latest book is Birds, Sex, and Beauty.He served the House of Lords between 2013 and 2021 and served on the science and technology select committee and the artificial intelligence select committee.He was founding chairman of the International Centre for Life in Newcastle. He created the Mind and Matter column in the Wall Street Journal in 2010 and was a columnist for the Times 2013-2018. He is a fellow of the Royal Society of Literature and of the Academy of Medical Sciences, and a foreign honorary member of the American Academy of Arts and Sciences. He lives in Northumberland.In this episode, we talk about:The myth of “disruptive innovation” and the overlooked beauty of incremental progressThe real relationship between basic science and technologyWhy Ridley still calls himself a “rational optimist”Why freedom, not brilliance, is the secret sauce of innovationHow universities and industry can collaborate to keep creativity aliveTo learn more about Matt's work, you can find him at: https://www.mattridley.co.uk/ Books and resources mentioned:Birds, Sex and Beauty (by Matt Ridley) How Innovation Works (by Matt Ridley)The Rational Optimist (by Matt Ridley)The Mating Mind (by Geoffrey Miller)The Descent of Man (by Charles Darwin)The Genetical Theory of Natural Selection (by Ronald Fisher)Survival of the Prettiest: The Science of Beauty (by Nancy Etcoff)The Rational Optimist Society – rationaloptimistsociety.com This season of the podcast is sponsored by Templeton Religion Trust.Support the show

Découvrez comment, partis des steppes pontiques, les Yamnayas ont laissé leur empreinte dans nos langues, nos gènes et notre culture. Cette grande migration indo-européenne a bouleversé la préhistoire : entre fusion des peuples, échanges culturels et héritage durable, les Indo-Européens ont refaçonné l'Europe. #génétique #archéologie Retrouvez le script, la bibliographie complète et les crédits sonores et graphiques sur : https://ladentbleue.fr/migration-indo-europeenne-europe-yamnaya-ceramique-cordee Suivez La Dent Bleue sur :

In Episode 2 of this season, we explore the evolution of beauty (especially in birds) and the beauty of innovation, with guest Matt Ridley.Matt Ridley's books have sold over a million copies, been translated into 31 languages and won several awards. His books include The Red Queen, Genome, The Rational Optimist and The Evolution of Everything. His book on “How Innovation Works” was published in 2020, and "Viral: the search for the origin of covid-19", co-authored with Alina Chan, was published in 2021.He served the House of Lords between 2013 and 2021 and served on the science and technology select committee and the artificial intelligence select committee.He was founding chairman of the International Centre for Life in Newcastle. He created the Mind and Matter column in the Wall Street Journal in 2010 and was a columnist for the Times 2013-2018. He is a fellow of the Royal Society of Literature and of the Academy of Medical Sciences, and a foreign honorary member of the American Academy of Arts and Sciences.He lives in Northumberland.In this episode, we talk about:How Ridley's childhood fascination with birds led him to study evolutionThe courtship rituals of black grouse and the surprising role of female choiceHow Ronald Fisher's “sexy sons” hypothesis changed everythingWhat bowerbirds can teach us about aesthetics and artSexual selection as a driver of creativity, humor, and the human brainTo learn more about Matt's work, you can find him at: https://www.mattridley.co.uk/ Books and resources mentioned:Birds, Sex and Beauty (by Matt Ridley) How Innovation Works (by Matt Ridley)The Rational Optimist (by Matt Ridley)The Mating Mind (by Geoffrey Miller)The Descent of Man (by Charles Darwin)The Genetical Theory of Natural Selection (by Ronald Fisher)Survival of the Prettiest: The Science of Beauty (by Nancy Etcoff)The Rational Optimist Society – rationaloptimistsociety.com This season of the podcast is sponsored by Templeton Religion Trust.Support the show

AI Daily Rundown: September 19th, 2025: Your daily briefing on the real world business impact of AIHello AI Unraveled listeners, and welcome to today's news where we cut through the hype to find the real-world business impact of AI.Today's Headlines:

Ulrike Granögger is a researcher and lecturer passionate about the convergence of science with spirituality. Ulrike's background is as a linguist, however, she has been one of the foremost exponents of ‘alternative' or ‘future' science. With the attitude of a noble journalist, she has met, interviewed and understood the work of many scientists at the fringe of their profession. This has allowed her to explore ideas of quantum biology and the holographic nature of genetic material. Ulrike also contributes to Catherine Austin Fitts' Solari Report, where she regularly writes and speaks about topics under the umbrella of ‘future science'.Please consider subscribing to my Substack where I share my detailed thoughts and insights on my podcast topics and beyond. This is the best way to support me and the podcast. https://ricciflow.substack.com/An additional solo podcast to accompany this conversation is available on my Substack if you'd like to go deeper into this topic: https://ricciflow.substack.com/p/ulrike-granoggerFollow UlrikeThe Solari ReportWave Genome DocumentaryPeter Gariaev's PublicationsPeter Gariaev TributeInstitute of LinguisticsReflections on Life and Intelligence on Planet EarthFollow MeWebsiteSubstackConsultationInstagramYoutubeTwitter/XSpotifyAppleLinktree

The study of DNA damage has broad relevance to human pathophysiology with its involvement in birth defects, cancer, premature aging syndromes, and certain neurologic disorders. Single strand breaks (SSBs) are among the most common form of endogenous DNA damage. Here we will describe mechanisms by which SSBs threaten genome integrity in mitotic and post-mitotic cells. If they are not resolved in a timely manner, SSBs can derail passing replication forks converting them to toxic double strand breaks (DSBs). These so called “collapsed forks” arise spontaneously in every S phase and are believed to be the primary physiological trigger of homologous recombination. We will describe a recent study using the CRISPR/Cas9 nicking enzymes to examine the interaction of the human replication machinery with SSBs. We combine direct analyses of DNA end structures at sites of DNA nick-induced fork collapse with detailed mapping of repair factor binding to establish a comprehensive high-resolution view of how replication-coupled DSBs are generated, processed, and repaired. Our recent studies have also identified unexpected high levels of single strand breakage in neurons, which arise during metabolic processes intrinsic to neuronal development, differentiation, and maintenance. The source of this “programmed” DNA breakage in neurons will be described, and how this physiological process can be corrupted to drive neurodegenerative diseases and neurotoxicity after chemotherapy. Through these basic research efforts, we hope to identify vulnerabilities specific to cancer cells and to discover mechanisms underpinning chemotherapy-induced neurotoxities, which may contribute to new preventive and treatment strategies.

My guest is Michael Snyder, PhD, professor of genetics at Stanford and an expert in understanding why people respond differently to various foods, supplements, behavioral and prescription interventions. We discuss how to optimize your health and lifespan according to what type of glucose responder you are, which genes you express, your lifestyle and other factors. Dr. Snyder also explains the key ages when you need to be particularly mindful about following certain health practices. We also discuss how people respond in opposite ways to different fiber types. This episode ought to be of interest and use to anyone seeking to understand their unique biological needs and how to go about meeting those needs. Sponsors AGZ by AG1: https://drinkag1.com/huberman Wealthfront*: https://wealthfront.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman *This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Timestamps 00:00 Michael Snyder 03:33 Healthy Glucose Range, Continuous Glucose Monitors CGM, Hemoglobin A1c 09:02 Individual Variability & Food Choice, Glucose Spikes & Sleepiness 12:18 Sponsors: AGZ by AG1 & Wealthfront 15:16 Glucose Spikes, Tools: Post-Meal Brisk Walk; Soleus “Push-Ups”; Exercise Snacks 21:06 Glucose Dysregulation, Diabetes & Sub-Phenotypes, Tool: Larger Morning Meal 28:34 Exercise Timing, Muscle Insulin Resistance 30:49 Diabetes Subtyping, Weight, Glucose Control; Incretins 35:41 GLP-1 Agonists, Diabetes, Tool: Muscle Maintenance & Resistance Training 38:40 Metformin, Berberine, Headaches 41:01 GLP-1 Agonists, Cognition, Longevity, Tool: Habits Support Medication; Cycling 47:41 Subcutaneous vs Visceral Fat, Organ Stress 49:10 Sponsors: David & Eight Sleep 51:58 Meal Timing & Sleep, Tools: Post-Dinner Walk, Routines, Bedtime Consistency 57:16 Microbiome, Immune System & Gut; Diet & Individual Variability 1:02:52 Fiber Types, Cholesterol & Glucose, Polyphenols 1:09:50 Food As Medicine; Fiber, Microbiome & Individual Variability; Probiotics 1:18:48 Sponsor: Function 1:20:35 Profiling Healthy Individuals, Genomes, Wearables 1:26:31 Whole-Body MRIs, Nodules, Healthy Baseline, Early Diagnosis 1:34:07 Sensors, CGM, Sleep, Heart Rate Variability HRV, Tools: Mindset Effects, Increase REM 1:39:30 HRV, Sleep, Exercise, Tool: Long Exhales; Next-Day Excitement & Sleep 1:42:48 Organ Aging, “Ageotypes”; Biological Age vs Chronological Age 1:49:41 Longevity, Health Span, Genetics, Blue Zones 1:52:19 Epigenetics, Viral Infection & Disease 1:58:54 ALS, Heritability; Neuroprotection, Nicotine 2:03:47 Air Quality, Allergies, DEET & Pesticides, Inflammation, Mold; Microplastics 2:15:02 Single-Drop Blood Test & Biomarkers, Wearables, Observational Trials 2:20:33 Acupuncture, Blood Pressure 2:26:40 Immersive Events & Mental Health Benefits 2:34:59 Data, Nutrition & Lifestyle; Siloed Health Care vs Personalized Medicine 2:43:06 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy.   References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15   Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

The first complete draft of the human genome was published back in 2003. Since then, researchers have worked both to improve the accuracy of human genetic data, and to expand its diversity, looking at the genetics of people from many different backgrounds. Three genetics experts join Host Ira Flatow to talk about a recent close examination of the genomes of 65 individuals from around the world, and how it may help researchers get a better understanding of genomic functioning and diversity.Guests:Dr. Christine Beck is an associate professor of genetics and genome sciences in the University of Connecticut Health Center and the Jackson Laboratory.Dr. Glennis Logsdon is an assistant professor of genetics and a core member of the Epigenetics Institute at the University of Pennsylvania.Dr. Adam Philippy is a Senior Investigator in the Center for Genomics and Data Science Research at the National Human Genome Research Institute at the NIH.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Jon wants to know, how do the cells in the human body, in all their variety, differ at the genetic level? James Tytko took his query on... Like this podcast? Please help us by supporting the Naked Scientists

In this episode of the Epigenetics Podcast, we talked with Dr. Joseph Ecker from the Salk Institute about his work on high-resolution genome-wide mapping technologies, specifically how the regulation of gene expression is influenced by DNA methylation, chromatin accessibility, and non-coding RNAs across various cell types and developmental stages. During our conversation, we delve into Dr. Ecker's contributions to the characterization of the genome of Arabidopsis thaliana, a project pivotal in the plant genomics field, where he collaborated on the early sequencing efforts that dramatically outpaced expectations. He highlights the technological advancements that enabled such efficient sequencing and how this foundational work opened new avenues for exploring transcriptional activity. We also discuss Dr. Ecker's pivotal work on the comprehensive DNA methylation map of Arabidopsis, which he developed in collaboration with other researchers. This groundbreaking study established the links between methylation patterns and gene expression, paving the way for further research into how these epigenetic marks influence over gene regulation. He elaborates on the significance of transitioning from traditional methods to more sophisticated techniques, such as RNA-seq, and the lessons learned from sequencing projects that have since been applied to human biology. Dr. Ecker's transition to studying human cells is further explored as he discusses the profiling of DNA methylation in induced pluripotent stem cells (iPSCs), revealing how epigenetic memory can influence cellular differentiation and development. He underscores the importance of understanding these methylation patterns, particularly as they relate to conditions like Alzheimer's disease and stem cell biology, where he examines potential applications of his findings in medical research. As our conversation progresses, we touch upon Dr. Ecker's ongoing projects that utilize advanced multi-omic techniques to investigate the epigenomes of the human brain, focusing on how DNA methylation and gene expression change with age and in the context of neurodegenerative diseases. He details the collaboration efforts with various consortia aimed at cataloging gene regulatory networks and understanding the complex interactions that take place within the brain throughout different life stages.   References Mozo T, Dewar K, Dunn P, Ecker JR, Fischer S, Kloska S, Lehrach H, Marra M, Martienssen R, Meier-Ewert S, Altmann T. A complete BAC-based physical map of the Arabidopsis thaliana genome. Nat Genet. 1999 Jul;22(3):271-5. doi: 10.1038/10334. PMID: 10391215. Zhang X, Yazaki J, Sundaresan A, Cokus S, Chan SW, Chen H, Henderson IR, Shinn P, Pellegrini M, Jacobsen SE, Ecker JR. Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell. 2006 Sep 22;126(6):1189-201. doi: 10.1016/j.cell.2006.08.003. Epub 2006 Aug 31. PMID: 16949657. Lister R, O'Malley RC, Tonti-Filippini J, Gregory BD, Berry CC, Millar AH, Ecker JR. Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell. 2008 May 2;133(3):523-36. doi: 10.1016/j.cell.2008.03.029. PMID: 18423832; PMCID: PMC2723732. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009 Nov 19;462(7271):315-22. doi: 10.1038/nature08514. Epub 2009 Oct 14. PMID: 19829295; PMCID: PMC2857523. Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O'Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011 Mar 3;471(7336):68-73. doi: 10.1038/nature09798. Epub 2011 Feb 2. Erratum in: Nature. 2014 Oct 2;514(7520):126. PMID: 21289626; PMCID: PMC3100360.   Related Episodes Epigenetic Reprogramming During Mammalian Development (Wolf Reik) Single Cell Epigenomics in Neuronal Development (Tim Petros)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

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In this interview, Lord Ridley examines the pervasive pessimism shaping climate narratives within the media and academia. He addresses the transformative power of affordable energy for developing nations and warns against beliefs about energy and climate that ignore the needs of those in poverty.Ridley also criticises the politicisation of science in both climate and Covid modelling, arguing it distorts evidence, suppresses debate, and drives harmful policies that undermine economic and social progress. He urges a shift towards optimism driven by innovation and evidence, advocating for rational energy policies and transparent scientific inquiry to foster prosperity and address global challenges effectively.Lord Matthew Ridley is a British science writer, journalist, and hereditary peer with a background in zoology and a distinguished career spanning academia, business, and public service. He holds a DPhil from Oxford University and is best known for his best-selling books on science, economics, and human progress, including The Rational Optimist, Genome, and How Innovation Works. Ridley served as chairman of the UK-based bank Northern Rock and was a member of the House of Lords from 2013 to 2021, where he contributed to debates on science, technology, and innovation policy. This interview was filmed at ARC London 2025.

First up on the podcast, Newsletter Editor Christie Wilcox joins host Sarah Crespi to celebrate the 2-year anniversary of ScienceAdviser with many stories about the amazing water bear. They also discuss links between climate change, melting glaciers, and earthquakes in the Alps, as well as what is probably the first edible laser.   Next on the show, freelance producer Elah Feder talks with Tatiana Feuerborn,  a postdoctoral fellow in the cancer genetics and comparative genomics branch of the National Institutes of Health, about the evolutionary history of the Greenland sled dog. Her team's work sequencing 98 genomes from modern and ancient sled dogs reveals the canine's current diversity and suggests approaches for conservation.   This week's episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Elah Feder; Christie Wilcox  Learn more about your ad choices. Visit megaphone.fm/adchoices

Join us for an exciting episode of The Edge of Show, live from Proof of Talk in Paris! In this episode, we dive deep into the intersection of blockchain technology and genetics with Aldo de Pape CEO and co-founder of Genomes.io. Discover how Genomes.io is revolutionizing the way we handle genetic data, ensuring safety and privacy while enabling scientific progress.Next, Joshua Field tells us how BitTensor is integrating blockchain with AI, creating decentralized networks for intelligence, and the implications of this technology for the future.Additionally, we hear from Arthur Breitman, co-founder of Tezos, as he discusses the evolution of the Tezos ecosystem, the importance of governance in blockchain, and their latest ventures into tokenizing commodities like uranium.Tune in to hear about:The role of blockchain in genetics and data privacyThe future of decentralized AI with BitTensorTezos' innovative projects and aspirations in the blockchain spaceInsights on the challenges and opportunities in the crypto industryWhether you're a blockchain enthusiast, a tech innovator, or just curious about the future of digital technology, this episode is packed with valuable insights and thought-provoking discussions. Don't miss it!Support us through our Sponsors! ☕

Episode 310 An ancient Egyptian's complete genome has been read for the first time. The DNA of a man who lived in Egypt over 4500 years ago offers a new window into the ancient society and hints at surprising genetic connections with Mesopotamia. Based on forensic analysis of the man's skeleton and preserved images of different Egyptian occupations, the researchers think his most likely occupation was a potter. The team discusses what the breakthrough means for our understanding of early Egypt and even for the origin of writing. Wild orcas, or killer whales, have been seen giving gifts to humans - things like pieces of liver, rays and dead birds. This is the first time these apparent acts of altruism have been documented. Does this prove whales are capable of showing compassion or kindness? Images beamed back from the New Horizons spacecraft, which has left the solar system, have enabled the first test of interstellar navigation. By measuring the distance between two stars that it snapped images of, astronomers have been able to pinpoint its location in the galaxy. And in other interstellar news, we also just spotted an object hurtling towards our solar system. Recently named ‘Atlas', this object will be whizzing by in October, close enough for us to study. Chapters: (00:42) Ancient Egyptian genome sequenced (12:33) Killer whales give humans gifts (18:59) First demonstration of interstellar navigation Hosted by Rowan Hooper and Penny Sarchet, with guests Mike Marshall, Alex Wilkins, Joel Irish and Lori Marino. To read more about these stories, visit https://www.newscientist.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this deeply informative solosode, Dr. Mike Belkowski guides listeners through a comprehensive exploration of mitochondrial function and its profound connection to aging and longevity. Kicking off with a brief reflection on recent guest episodes and a teaser about an upcoming podcast rebrand, Mike then dives into a newly released scientific article from Cell Communication and Signaling titled “Mitochondrial Dysfunction in the Regulation of Aging and Aging-Related Diseases.”   Mike reads and unpacks dense but crucial sections from the paper, including:   The Structure and Function of MitochondriaHe outlines the intricacies of the electron transport chain, supercomplexes, and mitochondrial DNA, emphasizing their roles in energy production, oxidative stress, and aging. Key Cellular Processes Affected by MitochondriaTopics covered include metabolic regulation, calcium and ROS homeostasis, mitochondrial biogenesis, and autophagy, tying them all back to aging and degenerative diseases. Modulating Mitochondrial Function to Slow AgingMike highlights emerging research on mitochondrial nutrients (like CoQ10, alpha-lipoic acid, carnitine), lifestyle interventions (exercise, diet, intermittent fasting), and breakthrough therapies such as mitochondrial transfer and replacement therapies.     He also introduces BioLight's new supplement, BioBlue Fountain of Youth, emphasizing its inclusion of methylene blue or leucomethylene blue, urolithin A, adaptogenic mushrooms, shilajit, and PQQ—all aimed at mitochondrial optimization.   The episode wraps with a powerful message: movement is medicine. Exercise remains the most accessible and potent strategy to boost mitochondrial health naturally. Mike encourages listeners to stay active, get sunlight, engage in red light therapy, and embrace the mitochondrial lifestyle. If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key Quotes from Dr. Mike Belkowski: ​​“The mitochondrial space is going to be blown up in the next couple decades for sure… it's going to become a much larger, well-adopted aspect of health and wellness.” ​​“You don't want these dysfunctional cells or these dysfunctional mitochondria to linger around… you want them to be recycled and turned into new, healthy cells.”​“Exercise is the best way to have your endogenous program of mitogenesis running.” - Key points: 00:00 – Introduction: Mitochondrial Focus and Podcast Evolution 02:14 – Podcast Rebrand Announcement & Mitochondrial Mission 03:15 – Review of Article: Mitochondrial Dysfunction in Aging 04:09 – Structure of the Mitochondria: A Deep Dive 06:15 – Electron Transport Chain & Supercomplexes Explained 10:05 – Mitochondrial DNA, Genome, and Gene Expression 11:18 – New BioBlue Supplement Overview and Key Ingredients 14:01 – Mitochondrial Functions: Metabolism, Apoptosis, and Energy 16:29 – Calcium Homeostasis & ROS Generation 20:11 – Antioxidant Defense Systems in Mitochondria 22:15 – Overview of Remaining Sections in the Research Article 25:18 – Targeting Mitochondria to Slow Aging: Introduction 27:13 – Nutrients That Modulate Mitochondrial Function 29:29 – Hormetic Stress, Resilience, and Mitochondrial Biogenesis 31:22 – Calcium Modulators and Mitochondrial Stability 32:01 – Exercise as the Ultimate Mitochondrial Booster 35:03 – Exercise vs. Caloric Restriction in Mitochondrial Health 36:30 – Mitochondria-Supportive Diets and Nutrients 39:12 – Mitochondrial Therapy and Replacement Explained 42:18 – Mitochondrial Replacement for Age-Related Decline 44:17 – Cross-Tissue Mitochondrial Signaling in Aging 45:41 – Translational Research in Mitochondrial Therapeutics 49:08 – Future of Mitochondrial Medicine and Final Thoughts - Save 25% when you Subscribe & Save to a BioBundle!For a BioBundle, you choose: 1.) Any one BioBlue supplement(BioBlue, BioBlue (SR), BioBlue Leuco, BioBlue Calm, BioBlue Capsules or BioBlue Leuco Capsules)2.) Any one BioC60 supplement (Regular or Concentrated)   The BioBundle automatically saves you 15% on both of the supplements you choose. You save an additional 10% by choosing to Subscribe & Save to that BioBundle.   The 25% savings is passed along for every monthly delivery of your BioBundle. No discount code necessary! Discount automatically applied at checkout.   Shop BioBundle by clicking here! - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram Facebook

On today's episode, hear July's top pistachio article from West Coast Nut on the most comprehensive genome sequence of the pistachio yet, which may provide plant breeders with a genetic roadmap to develop improved cultivars. Read it online at wcngg.com or subscribe for free to receive West Coast Nut in your mailbox. Supporting the People who Support AgricultureThank you to this month's sponsors who makes it possible to get you your daily news. Please feel free to visit their website.2025 Crop Consultant Conference - https://myaglife.com/crop-consultant-conference/

"If you get a new kind of information, suddenly you can do something with it that you couldn't do before at all." In this episode of The Biotech Startups Podcast, Ivan Liachko shares how scientific curiosity and unexpected collaborations took him from DNA replication research in yeast at Cornell to a breakthrough in 3D genome mapping and the founding of Phase Genomics. Embracing Hi-C technology at the University of Washington, Ivan and his team unlocked a new kind of biological information, enabling scientists to assemble genomes and map complex microbial communities and their viruses—transforming what was once impossible into a new standard for genomics. His journey highlights how creativity, collaboration, and seizing serendipitous moments can drive the most impactful scientific innovations.

Today InPerspective with Dr. Harry Reeder June 24, 2025

In this episode Ed discusses the Soybean tentiform leafminer, an emergent insect pest of soybean, with Dr. Bob Koch of the University of Minnesota. Additional Resources Initial detections in soybean:  https://doi.org/10.1093/jipm/pmab038 Laboratory rearing methods:  https://scholar.valpo.edu/tgle/vol57/iss1/9/ Genome and genetic variability among populations: https://doi.org/10.1093/g3journal/jkaf021 Development and longevity:  https://doi.org/10.1093/ee/nvae059 Distinguishing stages and sexes:  https://doi.org/10.1093/aesa/saae040 Insecticide efficacy:  https://doi.org/10.1093/jee/toae249 Host range and host plant resistance:  https://doi.org/10.1093/jee/toaf098 Extension articles: https://extension.umn.edu/soybean-pest-management/soybean-tentiform-leafminer-minnesota-soybean https://blog-crop-news.extension.umn.edu/2024/01/the-soybean-tentiform-leafminer-has.html https://blog-crop-news.extension.umn.edu/2022/09/updates-on-new-leaf-mining-pest-of.html How to cite the podcast: Zaworski, E. (Host) and Koch, R. (Interviewee). S4:E23 (Podcast). Tunnels of Terror: Soybean Tentiform Leafminer. 6/18/25. In I See Dead Plants. Crop Protection Network.   Transcript

In this episode of the Epigenetics Podcast, we talked with Petra Hajkova from the MRC Laboratory of Medical Sciences about her work on epigenetics research on mammalian development, highlighting DNA methylation, histone modifications, and TET enzymes, along with her journey in molecular genetics and future research on epigenetic maintenance. Dr. Hajkova's early work focused on DNA methylation and resulted in innovative collaboration that allowed her to develop bisulfide sequencing techniques. We discuss her transition to the UK, where she began working in Azim Surani's lab at the University of Cambridge. Dr. Hajkova describes the excitement of researching chromatin dynamics in the mouse germline, leading to significant findings published in Nature. Her story highlights the intense yet rewarding nature of postdoctoral research as she navigated the complexities of working with embryos for the first time. As her research progressed, Dr. Hajkova established her own lab at the MRC London Institute of Medical Sciences, where she became a professor in 2017. We delve into her investigations on the differences between embryonic stem cells and embryonic germ cells regarding their distinct developmental origins. Dr. Hajkova outlines the challenges she faced in understanding the mechanisms behind global DNA demethylation in germline cells and the role of hydroxymethylation during early development. The discussion further covers her exciting findings regarding the specific functions of TET enzymes and their regulatory roles in maintaining epigenetic states. We explore her recent research published in Nature, which provides insights into the transition from primordial germ cells to gonocytes, emphasizing the significance of various epigenetic mechanisms in germline development.   References Hajkova P, Ancelin K, Waldmann T, Lacoste N, Lange UC, Cesari F, Lee C, Almouzni G, Schneider R, Surani MA. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature. 2008 Apr 17;452(7189):877-81. doi: 10.1038/nature06714. Epub 2008 Mar 19. PMID: 18354397; PMCID: PMC3847605. Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science. 2010 Jul 2;329(5987):78-82. doi: 10.1126/science.1187945. PMID: 20595612; PMCID: PMC3863715. Hill PWS, Leitch HG, Requena CE, Sun Z, Amouroux R, Roman-Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Bagci H, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Nature. 2018 Mar 15;555(7696):392-396. doi: 10.1038/nature25964. Epub 2018 Mar 7. PMID: 29513657; PMCID: PMC5856367. Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P. Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742. doi: 10.1038/s41586-021-04208-5. Epub 2021 Dec 8. PMID: 34880491.   Related Episodes Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou) Epigenetic Reprogramming During Mammalian Development (Wolf Reik) DNA Methylation and Mammalian Development (Déborah Bourc'his)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Welcome to another wide-ranging "Random Show" episode I recorded with my close friend Kevin Rose (digg.com)! We cover dozens of topics: from the cutting edge of health tech to pro-tips for colonoscopies; AI; adventures in Japan and Taiwan seeking out perfect coffee and tea; tips for drinking less alcohol; powerful documentaries like 32 Sounds and books such as Awareness; the unexpected joys and therapeutic benefits of adult Lego; and much, much more.Sponsors:Vanta trusted compliance and security platform: https://vanta.com/tim ($1000 off) Momentous high-quality supplements: https://livemomentous.com/tim (code TIM for up to 35% off)ExpressVPN high-speed, secure, and anonymous VPN service: https://www.expressvpn.com/tim (get 3 or 4 months free on their annual plans)*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode:00:46 A potato pangenomeResearchers have created a ‘pangenome' containing the genomes of multiple potato types, something they believe can help make it easier to breed and sequence new varieties. The potato's complicated genetics has made it difficult to sequence the plant's genome, but improvements in technology have allowed the team to combine sequences, allowing then to look for subtle differences in between varieties.Research Article: Sun et al.09:57 Research HighlightsHow ancient DNA analysis revealed that unusually bound medieval books are covered in sealskin, and top quarks and their antimatter counterparts are detected after nuclear smash-ups at the Large Hadron Collider.Research Highlight: Mystery of medieval manuscripts revealed by ancient DNAResearch Highlight: Top quarks spotted at mega-detector could reveal clues to early Universe12:30 The top cited twenty-first century research papersAnalysis from Nature reveals the 25 highest-cited papers published this century and explores why they are breaking records. We hear about the field that got the highest number of papers on the list, and whether any feature in the all-time top citation list.News Feature: Exclusive: the most-cited papers of the twenty-first centuryNews Feature: These are the most-cited research papers of all timeNews Feature: Science's golden oldies: the decades-old research papers still heavily cited today21:47 Briefing ChatRe-analysis of a cosmic collision shows evidence of a planet spiralling into its host star, and how shrugging off lighting strikes gives tonka bean trees an evolutionary edge.Science: Astronomers spot a planetary ‘suicide'Live Science: Tropical tree in Panama has evolved to kill its 'enemies' with lightningVote for us in this year's Webby AwardsVote for How whales sing without drowning, an anatomical mystery solvedVote for What's in a name: Should offensive species names be changed? The organisms that honour dictators, racists and criminalsVote for Cancer-busting vaccines are coming: here's how they work Hosted on Acast. See acast.com/privacy for more information.