Podcasts about EED

In this episode of the BizNews Briefing we dig into the potential R24bn implication for SA of latest Trump Tariffs; hear from the IRR's Dr Anthea Jeffery how a voucher-based system (EED) which works elsewhere, including in India, is preferred by 81% of Black South Africans over the ANC's destructive BEE policies; get an update on the Captured State campaign against two lawyers commissioned to investigate Fort Hare corruption who refused to doctor their report as the cadres demanded; listen to examples from Stafford Masie on how Bitcoin is becoming part of the KasiEconomy; plus Col Chris Wyatt on the US's views on SA's next Ambassador to Washington and The Economist's investigation into progress by an entire industry that intends overcoming ageing - and death.

Delfino Camacho, an arts and life assistant for the Long Beach Current joins the episode to talk about the Oscars and other pop culture developments.Last Wednesday, Feb. 19 was the first open forum regarding the replacement of President Jane Close Conoley. The search is being conducted by a 17-person committee that includes staff, alumni, local community members and student representatives. All students, staff and faculty are encouraged to participate in the search. Go to csulb.edu/presidential-search to provide feedback to the committee.The Latinx Resource Center and the Black Resource Center join together for The Existence of Afro-Mexican Heritage and Identity. Starting at noon on Tuesday, Feb. 25 in EED-67, students will be able to enjoy a screening of the documentary "Jamaica & Tamarindo: Afro Traditions in the Heart of Mexico." Later on Tuesday, Feb. 25 at 4 p.m., the Black Resource Center is hosting Don't Touch My Hair 2, an event where students can learn more about their natural hair and get care tips. With opportunities to win free hair care products, the event will be held in the HC-130. On Thursday, Feb. 27 in the University Student Union Ballrooms is the Afro-Caribbean Social. The event starts at 4:30 p.m. and students will be able to explore more within their culture and create community. Girl's Day Festival also known as Hinamatsuri is a Japanese tradition typically held on March 3 to promote the health and happiness of young girls. On Sunday, March 2 the Earl Burns Miller Japanese Garden will be hosting their very own Girl's Day Festival. Starting at noon, this event will have crafts and music and is open for anyone to join. Tickets are $10 per group and free parking will be available in lot G4. Buy your tickets through the Events & Orgs app on your CSULB Single Sign-on.A new ride-share app is being introduced in Los Angeles and New York in which the drivers are armed with guns. The Protector app is essentially a bodyguard and driver at the click of a button. The drivers for the app are all active or veteran law enforcement and military. Starting with an annual membership fee of $129, booking a bodyguard costs an additional $200 per hour with a five-hour minimum.Egg prices have reached new heights as the avian flu is spreading amongst farms in America with the virus killing business for many poultry farmers across the nation. Since 2022, over 156 million birds have died as a result of the avian flu with newer strains beginning to appear in dairy cows last year. The Trump administration says they are trying to work out a plan that doesn't include killing off a sick flock but no further details were provided. Mexican president Claudia Sheinbaum proposed constitutional reforms to protect Mexican sovereignty on Feb. 21. These reforms were suggested after President Donald Trump declared eight Latin American criminal groups as terrorist organizations. Six of those eight groups are cartels in Mexico. Until the reforms go through, Mexico will not allow any foreign investigations, prosecutions or any other legal action without the collaboration of the Mexican government.Hospitalized last Friday, Feb. 14 for bronchitis, the Pope has been trying to recover but it was revealed on Monday that doctors discovered a respiratory tract infection. The next day, chest scans showed pneumonia in both lungs. While he is still being treated, officials say the Pope can get out of bed and eat breakfast.Host & Editor: Gianna EcheverriaProducers: El Nicklin, Aidan SwanepoelLike, comment, and follow us on your favorite platform for more content!Apple Podcastshttps://podcasts.apple.com/us/podcast/long-beach-current-podcasts/id1488484518Spotify⁠https://open.spotify.com/show/4HJaqJep02kHeIQy8op1n1⁠⁠⁠⁠Overcasthttps://overcast.fm/itunes1488484518/long-beach-current-podcasts

In this episode, we discuss how to handle situations where you stumble into something dangerous or illegal when liquidating a gun collection. -- To order “The Insider”: 20+ Years Of Indiscriminate Deliberations On Timely Topics by Roy Huntington, visit the FMG Publications Store or Amazon. EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Host Brent T. Wheat recently enlisted Roy Huntington's help with a shotgun restoration project, which inspired a conversation about what happened to the "old-school" gunsmith and what we should do to fix the problem.  EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

If we're being honest, carrying a gun all the time is a pain in the neck. In this episode, Roy Huntington and Brent T. Wheat discuss the truth of carrying a handgun for protection and how you can keep carrying one even when the thrill is gone! EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

In this episode we talk to veteran biker Roy Huntington for his thoughts on safe and practical motorcycle gun carry.  EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Gregg Ritz has brought Thompson/Center back from the dead. In this episode, you'll learn about how he did it and what his plans are for the future of this venerable brand. EPISODE SPONSORS The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. The GUNS Magazine Podcast is supported by HIVIZ Shooting Systems. HIVIZ® Shooting Systems is the designer, engineer and manufacturer of high-quality and innovative sights for handguns, shotguns, and rifles. From the unique molded LitePipe technology to their patented LiteWave H3® Tritium/Fiber-Optic sights and new FastDot H3®, HIVIZ continues to advance the art of shooting. See what you've been missing at www.hivizsights.com. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Darryl Bolke is a proponent of smaller calibers in wheelguns for self-defense. In this episode, he shares why he thinks the .32 caliber hits the sweet spot in power versus controllability. Tell us what you think in the comments: Is the .32 better than the .44 Magnum? Related Link • AmericanFightingRevolver.com EPISODE SPONSORS The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. The GUNS Magazine Podcast is supported by HIVIZ Shooting Systems. HIVIZ® Shooting Systems is the designer, engineer and manufacturer of high-quality and innovative sights for handguns, shotguns, and rifles. From the unique molded LitePipe technology to their patented LiteWave H3® Tritium/Fiber-Optic sights and new FastDot H3®, HIVIZ continues to advance the art of shooting. See what you've been missing at www.hivizsights.com. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Joel Kolander from Rock Island Auction Company joins us to talk about the upcoming sale of the "Marshfield Find" — a Winchester Model 1886 Rifle — plus Pat Garrett's gold-plated pistol and badge, and many other cool guns.  EPISODE SPONSORS The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. The GUNS Magazine Podcast is supported by HIVIZ Shooting Systems. HIVIZ® Shooting Systems is the designer, engineer and manufacturer of high-quality and innovative sights for handguns, shotguns, and rifles. From the unique molded LitePipe technology to their patented LiteWave H3® Tritium/Fiber-Optic sights and new FastDot H3®, HIVIZ continues to advance the art of shooting. See what you've been missing at www.hivizsights.com. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Confused about the difference between open- and closed-emitter red dot optics? In this episode, AmericanCOP.com Editor Eric Gelhaus shares helpful tips on how to pick the best optic for your particular situation and gun. EPISODE SPONSORS The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. The GUNS Magazine Podcast is supported by HIVIZ Shooting Systems. HIVIZ® Shooting Systems is the designer, engineer and manufacturer of high-quality and innovative sights for handguns, shotguns, and rifles. From the unique molded LitePipe technology to their patented LiteWave H3® Tritium/Fiber-Optic sights and new FastDot H3®, HIVIZ continues to advance the art of shooting. See what you've been missing at www.hivizsights.com. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Not all mass shooters are severely mentally ill, but many certainly are. Unfortunately, "the narrative" disingenuously wants to blame firearms rather than the person pulling the trigger, regardless of their motivation. In this episode, Will Dabbs, MD joins us to talk about what untreated mental illness looks like "on the street." EPISODE SPONSORS The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. The GUNS Magazine Podcast is supported by HIVIZ Shooting Systems. HIVIZ® Shooting Systems is the designer, engineer and manufacturer of high-quality and innovative sights for handguns, shotguns, and rifles. From the unique molded LitePipe technology to their patented LiteWave H3® Tritium/Fiber-Optic sights and new FastDot H3®, HIVIZ continues to advance the art of shooting. See what you've been missing at www.hivizsights.com. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Are you enthralled by the glamour of the red carpet at the Oscars? We aren't either, but we are interested in what goes on behind the scenes! In today's episode, Suzi Huntington talks about her time as a protective agent working Hollywood's biggest night. EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

In this week's episode, GUNS Magazine Editor Brent T. Wheat and Roy Huntington talk about Brent's new "travel" gun — a 2" J-Frame revolver — and why he chose it.  EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

GUNS Magazine Editor and Podcast host Brent T. Wheat has finally joined "The Church of the Snubbie," so naturally, Roy Huntington was his first call. Tune in for more about the used J-Frame revolver he couldn't resist and why. YOU MAY ALSO LIKE • Snubbies are Stupid! — GMP #233 • Snubbies: For Experts Only! — GMP #184  • J, K, L, N, M? E-I-E-I-O ... Demystifying All Those S&W Frame Types by Frank Jardim EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

Thompson/Center is dead and gone, right? Wrong! T/C is once again family-owned and in the midst of a rebirth. GUNS Magazine Editor Brent T. Wheat and Roy Huntington have the inside scoop! RELATED LINKS • Thompson/Center, tcarms.com EPISODE SPONSOR The GUNS Magazine Podcast is presented by Riton Optics. Riton Optics has a solution for your optics needs, but the very latest from Riton is the 3 Tactix lineup of pistol red dots. The 3 Tactix PRD, MPRD, and EED marry with the RMR, RMSc and ACRO footprint, respectively, and offer the features you need for that EDC or competition pistol. Learn more about the 3 Tactix Red Dots or the entire lineup at www.ritonoptics.com and use code GUNS24 for 15% off at checkout. -- Have a topic idea or guest you'd like to see in a future episode? Let us know in the comments or email podcast@gunsmagazine.com. Never miss an episode! Subscribe to our YouTube channel or sign-up for our newsletter (https://gunsmagazine.com/newsletters) to get the GUNS Magazine Podcast delivered straight to your inbox each week.

In this Legally Speaking edition, we speak with Assistant Solicitor General Karen Klucznik about the recent State v. Smith Appeals Court victory. The Utah Court of Appeals recently ruled in favor of the Utah Attorney General's Office, and on behalf of victims, by setting limits to the widely-used Extreme Emotional Distress defense in murder cases. It's taken more than a decade for this case to work through the Utah legal process. With the help of recent legislation, new standards apply about when a defendant can say in court that they 'lost control' and shouldn't face the maximum penalty because they reacted violently to a situation. This case centers on Daniel Smith, a husband who shot his wife seven times - 25 minutes after she told him she wanted a divorce and was leaving him. He said he was traumatized and shot his wife in an emotional haze. So, he wanted to claim an extreme emotional distress defense that would have lowered a murder conviction to manslaughter. Based on the case facts, the trial court denied the defense. The Utah Court of Appeals recently affirmed the trial court's ruling and Smith's murder conviction. The bottom line is, because of the statutory changes to the EED defense and the court of appeals' ruling, defendants who kill their intimate partners when their partners try to leave may find they are less able to use the extreme emotional defense as a mitigating factor, due to the timeline, level of violence, and other factors. Assistant SG Klucznik has argued extreme emotional distress cases for many years and joins us now to examine the implications of the Appeals Court ruling.

Anna is back and we're talking all about the white paper Anna created for the Teacher Friday Workbox®. When Anna came to me with this pink sparkly box of Teacher Friday Workbox® opportunities, I wanted to talk shop. Anna was almost done with her EED and I am still very much tied up with the PhD. So it was a win-win to have Anna complete a white paper. It is so interesting that there is literature and media supporting what I have been saying all along. Anna's supportive data came from her EED education and mine is coming from my PhD education. Anna shared that for the school year 2023-24, Tennessee reported 3.900 teacher vacancies and Virginia reported 3.9% of teacher positions were not filled. There is a real teacher retention problem and with the help of Anna (and don't forget Jayme!), we are out to shine light on the issues and increase teacher retention.  There IS Money There is personal development money schools can be using that is not earmarked for the operations of or in the buildings. Schools have these funds and aren't always sure how or where to spend them. Yes, you can offer self care like maybe a massage day for the teachers, but it's a temporary fix. Give the teachers a raise! But that is costly to an already dwindling budget. An easy answer will be the Friday Workbox® or the course from Ashland University that rewards them with CEU's. How Does The Teacher Friday Workbox® Actually Help Educators So how is the Teacher Friday Workbox® like self care? Most of you have heard on the podcast that a lot of teachers have purchased the Teacher Friday Workbox® on their own. They were looking for a solution and treated themselves to organization. As the number of tasks go up, so does the teacher's burnout level. A person needs to see the work before they can start to strategize a solution. The Teacher Friday Workbox® helps to identify all the invisible tasks. Then teachers can decide if they need to eliminate, delegate, or plan for each task. Task Switching We have all heard the stats about how costly in time it is to constantly be switching between tasks. The Teacher Friday Workbox® helps you to identify tasks in similar categories (the task specific slash pockets). When you pull out an IEP for a specific student, you can focus on all the tasks needed to be completed for that one student. Our brain likes this focus on one task and stress is reduced.  Reduce Cognitive Load on Working Memory Color coding is so productive for our brains. And I know I have nerded out about the connection in the brain when we write things down. That activity of pen to paper is so impactful on our brains and with recall. Cue the index cards. You write everything down. You don't stress over remembering what you are trying to remember. The Teacher Friday Workbox® allows you to use your brain as a brain and not a filing cabinet.  Community When Anna really stopped to think about what teachers needed in a resource that could decrease burnout …it was the Teacher Friday Workbox®! She also pointed out the value of community that you get. It's nice to have positive voices outside of your building. It's nice to see what others are struggling with as well as celebrating wins. AND it's private from parents and students. It's a safe space for all things teaching.  What is included in the Teacher Friday Workbox®? Red Workbox (roughly the size of a watermelon) One Set of Rainbow Slash Pockets Sets of 5 of Red, Orange, Yellow, Green, Purple, and Pink Online Dashboard Online Private Community Teacher Camp (first two weeks of July) During the Summer - Thursday night coworking time with replays Lifetime Access EPISODE RESOURCES: Teacher Friday Workbox® Managing Executive Functions with the Teacher Workbox (Ashland University) Sign Up for the Organize 365® Newsletter  On the Wednesday podcast, I get to talk with members of the Organize 365­® community as they share the challenges, progress, missteps and triumphs along their organizing journey. I am grateful that you are reaching out to share with me and with this community. You can see and hear transformation in action. If you are ready to share your story with us, please apply at https://organize365.com/wednesday. Did you enjoy this episode? Please leave a rating and review in your favorite podcast app. Share this episode with a friend and be sure to tag Organize 365® when you share on social media!

I want to introduce you to another educator that is embracing the Teacher Friday Workbox® and values the benefits teachers experience when using it. Anna found Organize 365® through podcast interviews I'd done on other shows. Anna knows the transformation that results from the physical products and the blitzes from Organize 365®.  Turns out, I could have known Anna many years ago when her mom was a Creative Memories consultant. Her mother's innovation with power layouts in scrapbooking helped me to create many scrapbooks in very short amounts of time. Anna always knew she wanted to be a teacher. She shared memories of teaching her younger brother after an enriching day at kindergarten herself. Anna, now in education in a supporting role outside the school buildings (NOT how you may imagine), values the Teacher Friday Workbox® so much that she created a college course for educators that she will be facilitating that results in 3 college credits at Ashland University.  Anna did go to college to be a teacher, but got pulled in a different path. As she “created her own degree,” Anna got to experience emerging adulthood first hand. This is yet another point of connection for Anna and me. After completing her graduate degree at University of Maryland, she moved back to Ohio. While starting her new life she started a small sewing business. She took a substitute teacher position which turned into a Family and Consumer Science (AKA Home Economics) teaching position for the next 6 years. During the pandemic, she created virtual/visual teaching materials for teachers. All of the teachers were looking for help and Anna was right there supporting them.  Her next move? She was experiencing a golden window, what better time is there to explore? Over the past year, Anna has had the freedom to explore many opportunities. During her exploration she took courses from Ashland University. She was so impressed with her experience that she approached them and said “Hey, how about I come work for you?” Anna's transition from being a classroom teacher to becoming an adjunct professor at Ashland University in Ohio is a testament to her dedication to education. Equally, her involvement with Organize 365® highlights her ongoing commitment to addressing teacher overwhelm and burnout through practical, curriculum-aligned support. Anna has been very intrigued with the flow theory. She explained it as a task that challenges you enough to stay engaged. And also not so challenging that your desire to stay engaged dwindles. She wants to keep exploring this in her efforts to support teachers. This initiative, along with the new course she created, embodies her belief in equipping teachers with tools to manage their workloads effectively, thereby extending their careers and enriching student learning experiences.  Next week we'll be talking about the white paper Anna has created for Organize 365® and explore even more ways to support teachers in their essential work. EPISODE RESOURCES: Teacher Friday Workbox® Managing Executive Functions with the Teacher Workbox Sign Up for the Organize 365® Newsletter  On the Wednesday podcast, I get to talk with members of the Organize 365­® community as they share the challenges, progress, missteps and triumphs along their organizing journey. I am grateful that you are reaching out to share with me and with this community. You can see and hear transformation in action. If you are ready to share your story with us, please apply at https://organize365.com/wednesday. Did you enjoy this episode? Please leave a rating and review in your favorite podcast app. Share this episode with a friend and be sure to tag Organize 365® when you share on social media!

Schneider Electric Announces Evolution of EcoStruxure IT with Model Based, Automated Sustainability Metric Reporting New features offer enhanced visibility of energy and resource consumption, historical data analysis and detailed metrics to help organisations meet imminent regulatory reporting requirements. Includes a fast, intuitive, and simple-to-use reporting engine with third-party integration and data export features, all at the touch of a button. Are the result of three years of strategic investment, and rigorous testing and development as part of Schneider Electric's CIO-led Green IT Program. Sustainability Metric Reporting from Schneider Electric Schneider Electric, the leader in digital transformation of energy management and automation, today announced the introduction of new model based, automated sustainability reporting features within its award-winning EcoStruxure IT data centre infrastructure management (DCIM) software. The release follows three years of strategic investment, and rigorous testing and development as part of Schneider Electric's Green IT Program, led by Schneider Electric's Chief Information Officer Elizabeth Hackenson. Available to all EcoStruxure IT users starting in April, the new and enhanced reporting features combine 20 years of sustainability, regulatory, data centre and software development expertise with advanced machine learning. Customers will have access to a new set of reporting capabilities, which traditionally had required a deep understanding of manual data calculation methods. Unlike anything available in the market, the new model offers customers a fast, intuitive, and simple-to-use reporting engine to help meet imminent regulatory requirements, including the European Energy Efficiency Directive (EED). In fact, the new capabilities go far-beyond the EED-required metrics, ensuring customers can measure their data centres' real-time and historical energy performance data against all of the advanced reporting metrics specified within Schneider Electric's White Paper 67. EcoStruxure IT software enables owners and operators to measure and report data centre performance based on historical data and trends analysis, combining it with artificial intelligence (AI) and real-time monitoring to turn it into actionable insights for improved sustainability. With the new download function, organisations can quickly quantify and report, at the click of a button - removing laborious manual tasks and making it faster and easier to harness the power of data to reduce the environmental impact of their data centres. Key benefits include: Calculate and track PUE per site/room over time with CEN/CENLEC 50600-4-2 methodology. Leverage data analytic models and cloud-based data lake to simplify reporting of PUE. Report current power consumption per site room and report against historical trends. Utilise "click of a button" reporting for regulations. Witness trending over time for various data centres and distributed IT environments. Empower customers to securely access and manipulate their data in their preferred tool via third-party integration and data export. "At Schneider Electric, we recognise that sustainability is a journey, and for the last three years, we've increased our investment to develop new software features that make it faster and simpler for our customers to operate resilient, secure and sustainable IT infrastructure," said Kevin Brown, Senior Vice President, EcoStruxure IT, Schneider Electric. "The new reporting capabilities included with EcoStruxure IT have been tested and adopted by our own organisation, and will allow customers to turn complex data into meaningful information, and report on key sustainability metrics." A new era for Green IT In 2021, Schneider Electric released its Schneider Sustainability Impact (SSIs), publicising the company's sustainability commitments. Aligning with the SSI purpose, Schneider Electric's CIO Elizabeth Hackenson kickstarted the company's Green ...

Indianapolis' planned economic enhancement district, or EED, will not be repealed. A House committee yesterday heard testimony on a bill to put a moratorium on dedicated bus lanes. Several hundred abuse victims who are part of a large settlement with the Boy Scouts of America could get access to more money under a bill approved by a Senate committee yesterday. More and more rural hospitals across the country have stopped delivering babies in recent years - some rural hospitals have found ways to make these units survive. Want to go deeper on the stories you hear on WFYI News Now? Visit wfyi.org/news and follow us on social media to get comprehensive analysis and local news daily. Subscribe to WFYI News Now wherever you get your podcasts. Today's episode of WFYI News Now was produced by Darian Benson, Abriana Herron, Drew Daudelin and Kendall Antron with support from Sarah Neal-Estes.

Aujourd'hui je reçois à mon micro un duo qui m'a particulièrement touché. Il s'agit de Romane, une très vieille âme âgée de 17 ans, accompagnée de sa maman Caroline. Comment forger son chemin dans l'enfance et l'adolescence lorsque nos facultés médiumniques sont omniprésentes ? Comment garder confiance en soi quand on ne peut parler à personne de sa connexion au subtil ? Comment accompagner son enfant éveillé dans sa quête d'épanouissement ? Romane et Caroline nous racontent leur histoire : les épreuves, les difficultés mais aussi les rencontres qui ont tout changé et les belles prises de conscience à la clé. Je vous souhaite une bonne écoute et petite mise en garde, nous parlons dans cet épisode de dépression et de troubles alimentaires. // Documentaire "Être et Devenir" de Clara Bellar : http://www.etreetdevenir.com/EED.fr.html#Accueil// Pour souscrire à la newsletter, vous pouvez cliquer ici// Si vous souhaitez me soutenir, c'est par ici !Création Originale: Raphaële KranjcevicDirection Artistique: Eric C.Stratégie Digitale: Alix de CrécyMixage : Les Belles FréquencesMusique: Blacksmith Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

This episode is the first of a two part discussion about enrichment with Elly Neumann, Jerusalem Zoo and President Elect of The ABMA. The focus of this episode is Goal-Based Enrichment and the evolution of how we view and implement enrichment opportunities. Elly discusses what goal-based enrichment looks like, how to plan it, how to record it, and how to get a team to buy into it. And make sure you tune in for Elly's "Training (or Enrichment) Tale" about an "enrichment miracle" with a squirrel monkey. For questions or suggestions about the podcast email abc@theabma.org and to reach Elly with questions about the episode or Behavior Month contact presidentelect@theabma.org  Let's talk some training! 4:30 Intro to Elly  7:25 Info on Behavior Month and Engage  11:40 What is Enrichment?  14:00 What is an EED and why are we moving away from that term?  18:50 What is Goal-Based Enrichment?  24:50 Starting a Goal-Based Enrichment program 32:30 Planning and recording 37:50 What is enrichment and what is good husbandry and care?  40:00 Team involvement and buy-in  46:35 “Training Tale”  

“Informed Consent”, een combinatie van de informatieplicht en het toestemmingsvereiste die binnen de medische zorg gelden, is een essentieel onderdeel van zowel de juridische als medische voorschriften voor artsen. Zoals De Koninklijke Nederlandse Maatschappij tot Bevordering van de Geneeskunst (KNMG) schrijft: “zonder toestemming is er immers sprake van een ongeoorloofde inbreuk op de integriteit van een patiënt.” Die toestemming vereist de nodige informatie – tegelijkertijd zijn patiënten natuurlijk geen experts en kunnen ze informatie dus ook verkeerd interpreteren. Hoeveel moet een patiënt weten om in te kunnen stemmen? Buiten het medische kader gelden vergelijkbare vragen binnen bijvoorbeeld een ethische en politieke context. Hoeveel moet een werknemer of stemmer bijvoorbeeld weten om akkoord te kunnen gaan met een voorstel dat risico's met zich meebrengt voor natuur of maatschappij? Dit is de eerste van een dubbelaflevering over keuze. Aflevering 21 zal gaan over keuzestress. Te gast is Luc, eerstehulp arts in opleiding. www.herwaarns.nl Verwijzingen Intro KNMG. “Informed Consent”. 22 april 2022. https://www.knmg.nl/advies-richtlijnen/dossiers/informed-consent Luc De stethoscoop van Luc Kazuo Ishiguro. Klara and the Sun. Faber and Faber, 2021. De Eed van Hippocates: https://nl.wikipedia.org/wiki/Eed_van_Hippocrates Merel J. K. Rowling. Harry Potter and the Deathly Hallows. Bloomsbury, 2007. Overige verwijzingen Onderzoek: patienten vertrouwen mensen met stethoscoop Onderzoek onderzoek stofzuiger Risicopercentages Eliezer Yudkowsky. Harry Potter and the Methods of Rationality. https://hpmor.com/ (De sorteerhoedepside is in hoofdstukken 9 en 10) Existentialisme: Jean-Paul Sartre en Ambert Camus. Een begin: https://nl.wikipedia.org/wiki/Existentialisme https://youtu.be/hd3_VOEMCYY Spotify: https://open.spotify.com/episode/4RAUVlEdS4ilzwAzb2KAkF?si=273b5bda5c10421e

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.31.526222v1?rss=1 Authors: Dror, E., Fagnocchi, L., Wegert, V., Apostle, S., Grimaldi, B., Gruber, T., Panzeri, I., Heyne, S., Hoeffler, K. D., Kreiner, V., Ching, R., Lu, T. T.-H., Semwal, A., Johnson, B., Senapati, P., Lempradl, A. M., Schones, D., Imhof, A., Shen, H., Pospisilik, J. A. Abstract: Despite the recent explosion in surveys of cell-type heterogeneity, the mechanisms that specify and stabilize highly related cell subtypes remain poorly understood. Here, focusing initially on exploring quantitative histone mark heterogeneity, we identify two major sub-types of pancreatic {beta}-cells ({beta}HI and {beta}LO). {beta}HI and {beta}LO cells differ in their size, morphology, cytosolic and nuclear ultrastructure, transcriptional output, epigenomes, cell surface marker, and function. Importantly, {beta}HI and {beta}LO cells can be FACS separated live into CD24+ ({beta}HI) and CD24- ({beta}LO) fractions. From an epigenetic viewpoint, {beta}HI-cells exhibit ~4-fold higher levels of H3K27me3, more compacted chromatin, and distinct chromatin organization that associates with a specific pattern of transcriptional output. Functionally, {beta}HI cells have increased mitochondrial mass, activity, and insulin secretion both in vivo and ex vivo. Critically, Eed and Jmjd3 loss-of-function studies demonstrate that H3K27me3 dosage is a significant regulator of {beta}HI / {beta}LO cell ratio in vivo, yielding some of the first-ever specific models of {beta}-cell sub-type distortion. {beta}HI and {beta}LO sub-types are conserved in humans with {beta}HI-cells enriched in human Type-2 diabetes. These data identify two novel and fundamentally distinct {beta}-cell subtypes and identify epigenetic dosage as a novel regulator of {beta}-cell subtype specification and heterogeneity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

His Name...1. Declares His Identity (vv. 32-33)2. Declares His Poverty (vv. 26-28)3. Declares His Ministry (vv. 31)4. Declares His Glory (vv. 33)

Überblick: Achterbahnfahrt der Energiemarktpreise, Stahlwerke stellen Produktion ein, Websitetipp: Dena Tipps für Kurzfristmaßnahmen -  Einsparung in der Industrie, Drittes Entlastungspaket, Österreich beschließt Strompreisbremse, Europäische Notfallmaßnahmen gegen Energiepreiskrise, Realer Gasmangel, BImSchG-Reform, Habeck und Scholz in Canada, Stiftung H2Global, Ammoniak-Terminal in Vlissingen, Bau der ersten Direktreduktionsanlage, Abstimmungen im EU-Parlament über REDIII und EED, Stresstest, Atomkraftwerke bleiben in der Einsatzreserve, Standort für Endlager in der Schweiz gefunden, Prüfung des Klimaschutzsofortprogramms für Verkehr und Gebäude, Klima-Kipppunkte Kontakt: Twitter (redispatch_pod), LinkedIn (Redispatch), Instagram (Redispatch_Podcast), TikTok (redispatch) BMF (2022): Maßnahmenpaket des Bundes zur Sicherung einer bezahlbaren Energieversorgung und zur Stärkung der Einkommen. FfE (2022): Entwicklung der Energie- und CO2-Preise 2022 FfE (2022): Veränderungen der Merit Order und deren Auswirkungen auf den Strompreis H2Global Stiftung (2022): H2Global – Idee, Instrument und Intentionen Initiative Energieeffizienz- und Klimaschutz-Netzwerke (2022): Liste für Kurzfristmaßnahmen für Energieeinsparung und Energiesubstitution in Unternehmen (die Maßnahmenliste die in der Folge mit Verweis auf dena erwähnt wurde) Potsdam-Intitut für Klimafolgenforschung (2022): Kippelemente - Großrisiken im Erdsystem

This episode explores Wojciech's recent progress with the Fire Science show as well as his new chapter on Fire and Smoke Modeling in the "Handbook of Fire and the Environment". Tune in to hear about modeling fire and smoke in environments as big as city blocks.    Fire Science Show:  https://www.firescienceshow.com/   Handbook of Fire and the Environment https://bit.ly/3bCId0I   Transcription Gus Gagliardi: [00:00:00] Hello, all welcome to the show. I'm Gus Gagliardi, and this is fire code tech on fire code tech. We interview fire protection professionals from all different careers and backgrounds in order to provide insight and a resource for those in the field. My goal is to help you become a more informed fire protection. Professional fire code tech has interviews with engineers and researchers, fire marshals, and insurance professionals, and highlights topics like codes and standards, engineering systems, professional development, and trending topics in the industry. So if you're someone who wants to know more about fire protection or the fascinating stories of those who are in the field, you're in the right place. Hello, all welcome to episode 58 of fire code tech. On this episode, we're speaking once again with Wojciech Węgrzyński WOIC is a friend of the podcast and the host of the fire science show. In this episode, we get some updates on what has been happening with the fire science show and wojak details his chapter in the new published handbook titled the handbook of fire and the environment by S F P. Wojciech chapter in specific talks about fire and smoke modeling. He evaluates how we can use fire and smoke modeling to better understand how fires impact the environment and what methods we can use to predict and protect individuals from the hazard of fire and the pollutants that are. If you enjoyed this episode, please go check out the fire science show. He has a wide variety of topics, and he really gets at some fascinating scientific points of view that we don't as often cover on fire code tech. Don't forget to hit that subscribe button for fire code tech and the fire science show. And give us a follow on social media. Also, if you enjoy the content and you wanted to give us a big favor, give us a five star review on apple iTunes podcasts. Let's get into the show. welcome back to fire code tech. Thanks for coming on the show, sir. Thank you so much, GU thank you so much, GU very happy to be here with you again. Nice. Well, yeah, the fire code tech. Goes round two, I guess. Yeah. Or what is it? The fire science code tech show. That was, that was a good one. I really enjoyed. I really enjoyed that. That mashup was nice. One. It was fun. It was fun. Yeah. Well, I wanted to just, you know, start off by getting a update of like what you've been thinking about the podcast. We were chatting a little bit off air, but I'm sure everybody is interested about, you know, How you been feeling about it and what's been going on and just like a little bit of background on the, behind the scenes for Roja. Wojciech Węgrzyński: Yeah. Cool. I'm not, not very often sharing behind the scenes on fire sand in the fire science show. So I guess it makes more sense to share it in, in here. It's been fun. It's been a great year. Definitely a chance to meet and talk with people that I would not usually talk to. And that was, that was really good discovering a lot of new, super smart, super intelligent people who do groundbreaking research in fire for me as an academic broadening my, my field of view. So that has been excellent. And. I really like it, a lot people seem to like and enjoy it. So makes me very happy to, to get feedback from outside of my closet. and yeah, I, nowhere close to stopping doing that quite opposite. I'm I'm very. Happy to, to do this project, continue this project. And my head is buzzing with ideas, how to make it better, how to grow it. Gus Gagliardi: So many, so many new roots open up and I, I hope that. It's the early days of the fire science show. And you're gonna hear a lot more from it. Hopefully , we'll see. I would bet on it. I would bet on it with you behind the wheel, but no, that's awesome to hear about. Yeah. I, I definitely know what you mean about the podcast opening up new doors, but yeah, I was wondering with your newest riding endeavor that you were sharing with me. But like what kind of, how has the, like the symbiotic relationship of the podcast? Like how has that influenced other areas of your career? Because I know for me, it's, I've seen it have subtle and not so subtle influence on knowledge and just opportunities. Yeah. That's kind of an intriguing question, I guess. Wojciech Węgrzyński: I mean first, first things first I'm a scientist and an engineer I'm I'm podcaster is, is a third hat if I may. And definitely my, my prime career is as is the VO, the [00:05:00] scientist. I I'm the guy who does fire experiments and measures stuff and tries to publish that and shares the knowledge through academic papers mainly. So. It's difficult to say to what extended this world's overlapped that much. I would say that podcast is I found podcast as an excellent way to communicate the research. Like this is something absolutely. Great. And it it's working like magic and it, it was one of the reasons why I've started podcast. You know, sometimes you go to a conference and there's a person they're talking about their research. They're giving a 10 minute presentation and it's like, you can go asleep. Sometimes it's really difficult to. To capture all the knowledge that person is trying to share, giving their best. And I'm not saying people are lazy or something or, or unskilled, but it's just the way how it is in conferences. And then after the conference, you go for a beer with that person and you can spend like three hours in the pop talking about that research. And it is fascinating. And I couldn't get that out of my head. Why, you know, the same person, the same topic, the same thing in one place. It's very difficult to. On the other hand, it's so approachable. So nice. So juicy, like you can learn so much from talking to people and I figured out the context makes the difference and this human to human interaction makes the difference. And I've bet on that while starting the podcast and it worked out, it really seems to be the thing, like when you talk to people, they open up. When you ask them questions, they, they light up inside and they want to talk, you know, I, you may know the feeling of talking to a 200 people in the room and you don't really have a good idea if any of them is listening. like, you know, People on their phones. People were watching around someone talking with somebody else on the side, someone leaving the room, middle of the talk. You didn't know if they left because it's horrible talker. They just received a very important phone. You know, you don't know that it's stressful and here Once you forget, this is being recorded. Once you forget, this is going to be shared with hundreds of thousand or thousands of people you open up and, and you can just, you know, give the science to the world. And, and this is the interaction between podcasting and academia that. I enjoy the most, I must say I'm not taking that big advantage of, of my podcast with my research because there's a lot happening at ITB and, and at my research group, which I guess I could have a whole podcast about research. We are just doing, but I, I, I wanted my show to be a venue for everyone else and whole community of people, scientists. So yeah. That's number one. Influence. Yeah. Well maybe in one day you'll have. Media network, where you can have a whole litany of fire scientists talking on different podcasts on a channel one day. We don't know. I won't, I won't sell you short yet. I think you got it in you. Yeah. Media empire. That that'll be great. There you go. I, I thought at understand, I thought the fire science is too small, even for a podcast. So, but I was very wrong. I was very wrong. It's so niche. It's so niche. And like, I wonder that same thing sometimes I'm like, is it so. is it such a, like a small subset of an audience? Like, is there enough people? Gus Gagliardi: I really didn't even know. Like I was excited when I was having 10 or 12 people listen to the podcast. I was excited on a weekly basis. I was like, this is awesome. I can't believe that people are even listening to me right now. Like what, what the heck even is happening. So I, I love all what you're. I when thinking when, considering that I thought it is a small audience, but it's an audience that deserves a great, great shows, great content. Wojciech Węgrzyński: And let's do this and see what happens and, and it turned out cool. Yeah. From the opposite side, like how does podcasting influence my work as a scientist? I get the chance to listen every single episode of fire science here, because I record them. I edited them. I listen to them. So I'm a very solid consumer of my own content. And I, I honestly think listening to podcasts like. Yours and, and mine and there's others is probably the easiest way for passive career development. Like there, there is no other as easy investment of your time. Even in time it can be considered even entertainment in a way. And yet you learn so much. So from every interview, I, I learn something that eventually gets implemented in my science. But I would get that by listening to podcast. I wouldn't have to make the podcast to, to have that if I was just listening to, to the podcast, which I am, I, I would still benefit in a very, very similar way. So yeah, I think it's a great medium [00:10:00] and one that's very easy, but very rewarding. Gus Gagliardi: Yeah. Yeah, definitely. Well, I wanted to ask, I feel like I'm just getting selfish here and I'm asking you all the podcast questions up front, but I wanted to ask just like, and I think you've like spoke a little bit about, you know, how it's been and. How things are going, but yeah, I mean, like, I love hearing about your, you saying you're, you're scheming, you're thinking about ways to grow it, but like what dreams do you have, if you could share any for what you would like to do with the fire science show? Like yeah. Where would, where do you see it going? Yeah, first and foremost, I would like it to continue. Very long time. Like I would love to one day wake up and think about, I dunno, 10 years of interviews I've done with the fire scientists, you know, see in the podcast reflection of how the field grown, how it evolved, how one thought fueled another. Wojciech Węgrzyński: I, I mean, doing it for a year, I can already I, I can already see Repository of hours of, of interesting interviews, but I really wonder how will it look after like five or 10 years of doing that? How big it'll be? What, what great thoughts will be in it? I would love to know interview today. Some. Undergraduate student learned that 10 years forward their famous professor and, and it was first communicated. These are the dreams, you know, really they're very down to earth. I, I don't dream about building a tycoon of, of podcasts or, or having I don't know, the number one show on the planet or so that I don't care that much. I'm reaching my goals with what I'm doing. I would honestly like really love to continue and just like reflect on how it influences lives of others. That's. That's very rewarding on, on its own. Obviously I would love to get the show sponsored one day or, or, you know, get something rolling that. And I think it's important for, for podcast long longevity, you know, it's, it's it's, it's, it's a thing that definitely helps, but it's not a goal on its own. Gus Gagliardi: It's something that would be nice as an, as an added part of this routine. Yeah, I think it's, I, I mean, I'm sure you're already at a place where if you just started going and chasing sponsors, you could get 'em it's just the time to do all that on top of yeah. Your, your three other jobs. You got your you're an engineer, you're a scientist you're podcast. You're a father like, yeah, you got, maybe you spare a couple seconds left in the day that you probably need for your sanity. So if you, if you're really one of those sponsors, I'm sure you could go get 'em, but I love. I feel like you have like a philosopher's soul when you speak about these things that, oh, thank you. Wojciech Węgrzyński: I always enjoy listening to. But I find myself just like going into, I'm listening to a wojak podcast mode, even though I'm supposed to be interview interviewing you. So I need to be careful about listening to you. okay. That's cool. I'll I'll I'll just pop a three minute timer to not exceed you just make sure you start snapping. Gus Gagliardi: If I look like I'm glazed over and I'm just like listening to you too. Intently kill man. No I wanted to talk to you. You shared with me like a new project that she had just finished. And I saw that Brian Meachum was sharing it on link two, LinkedIn too, after we were talking about it and super exciting, but I really wanted to dive in in this conversation and talk about your new chapter in the handbook of fire and the environ. Wojciech Węgrzyński: It was, is such an exciting project. And I was delighted to be invited by Brian to participate in, in that project. It's a handbook it's called a handbook of fire and environment. It's within the, let's say environment of, of SF P handbooks. So it's, it's a completely new development that hopefully will be sustained and growing as, as it as its own thing. It's. Large. Well, handbook is a large book. It it's large book many chapters with, with great, great people, all focused around the environmental impact of fires on the environment, but also in a cultural way, in a social economic way. So all the, all the different ways, how fires impact society. Editors of the book are Brian Mitchum, who you've mentioned, and professor Margaret Magna me from Sweden. So they're, they're, they're both co-editors of the, of the book. They were leading the whole thing. And I even had, I had Margaret on my podcast some time ago, we were talking about sustainability in build environment. And this is also something that, that fits into the puzzle of, of fires and the environment. So the book itself, [00:15:00] it started, I know three, maybe four years ago. It takes a long time to publish a handbook, man. It's like you and me are on a tight schedule with the podcast and almost a weekly. It takes years to publish a book of this magnitude. And it it's, it's amazing. It's even if you do your best job and at the moment when it's published, the, the references in it are already two years old because it takes so much time to process the book, but ah, it's, it's cool. The book is, the book is out there and the knowledge there is is worth sharing. Absolutely. If you want sorry. The, the story of the handbook like goes, goes far back and it's it has been triggered by the how fires do damage environment. We we've been more and more. You know, aware of the effects fires due to environment in terms of smoke, polluting the air in terms of the soil and water damage that is done from fire and extinguishing actions. We had some huge, like petrochemical fires, huge chemical plant fires that. Their ethics on the environment around was very profound, but we also had fires like the tragic gr tower or the Notre Dame, par cathedral fires, which were just buildings inside of a city. And yet they had environmental consequences. If you look through that layer on them. So it it's something we are becoming more and more aware. And this handbook was a way to answer this need for the society to be able to quantify, measure, model that, to better understand this impacts. So yeah, that's the handbook. Yeah. Wow. That's that's incredible to hear you talk about like the scope of a document like this. Gus Gagliardi: I mean, I guess it makes complete sense when you have this many authors this much like peer review and, and this much just process to compile it all, you have thousands of pages probably. Or I don't know how roughly how long it is, but it's it's like 500, but it's, it's, it's a massive work. Yeah. 500 man. That's still like a dense, dense, but man, so much to be gleaned about it too. And so I, you know, was But, yeah, it's exciting and cool to see a little bit of your, your wind talk. You know, I didn't get through the entire chapter over that you wrote, but, oh man. It's it's it's way through and probably take with me. Take me months to get through it, but I was like trying to read it and UN not just read it, but understand it, you know, I could read it and just like go through it and my eyes go over and be like, yep. That went inside my brain for a moment. Or just like go through it, try to pick it apart. I was taking notes, but it was really interesting to. Get like a little bit more on your, on your wind talk. And I feel like that's your baby, you know, like this, this idea and this thing that you really love to. So it was cool for me to get a little bit of a peek behind the, the curtain for. For that lecture and that discussion that we had talked about. And honestly, when we were doing our first talk, you were given hints about the win talk when you came back. Yeah. So it was like perfect timing. Perfect timing. yeah. So, but yeah, but I'll, so let's get into that. Let's talk about like, you know, I guess let's get into. So like who would benefit from reading this book? Like, who's kind of like the, the audience or the target. I mean, I can definitely see. People who like yourself and, and like the firm I work for at times, like performance based design professionals are people who deal with fire and the, you know, just the sociology of it, the science of it, all the parameters, like they can benefit by reading your chapter. But yeah, maybe you have a greater sense of who's a good audience for this document. It's it's a tough question, you know, because I would love to say everybody and that's a horrible answer to such post questions, which I now know being a content creator, if your content is for everybody, it's for no one. Wojciech Węgrzyński: So, so I'll try to Wrap up who would be a perfect recipient of this chapter, like who I would like to give this book in a president and tell them you would really, really benefit from reading this. And I, I think it would be an engineer, not necessarily dealing with the building design, but one that wants to understand a bigger picture or because of the work they're doing. They have to. Understand the bigger picture, the context of what they're being designing, be the building, a tunnel, a road, a system you know a bigger community even. If, if you are involved in, in [00:20:00] design and you would like to understand another layer of perception of your. If you're in the building, we usually care. Okay. Is your ISA time higher than your required time? And if that is you're good, if not, then you're bad. What are your concentrations inside? But as soon as you know, the smoke is exhausted outside of that compartment, you don't think about words going to fly. How far can it fly? Who's going to be vulnerable to that smoke. And actually even how much will there be? Eed out of your fire. It's not something we consider today that much while designing buildings or other systems. I'm not saying we should always do that, but I am also sure that in certain cases we would benefit from understanding what our what our buildings, what, what threats our building pose to the surroundings. As I mentioned the cases of Grandful or, or Nord Dame, it was a single building burned down. And yet it had some environmental consequences in its nearest surroundings outside of all the other damage that was caused by these tragedies. So even as a fire of a single building can do a lot of harm to the surroundings. And to understand that, like how can you. Understand what the impact will be. You, you have to calculate it in a way like we're engineers. We, we are supposed to not give a random answer based on our feeling or intuition, but we are all to calculate and then measure and, and model. So this is what. We were invited for in this chapter previously, as you've mentioned, we've been known for our work in wind and fire, coupled modeling and environmental modeling of the fire outcomes is largely related to the atmospheric winds. I mean, winds will be driving force for the, for the contamination. So it was very Easy to find a link between our work that was focusing on the winds and fires inside the buildings and extending it to understand how the winds affect the, the, the consequences of the fire outside of the building. We were focused on the inside, but it was very easy switch to also take a look at the greater picture outside now. One thing that we were doing, we were usually focusing on numerical modeling with CFD computational fluid dynamics, which is something that gives you great answers, but in the very near proximity of your building, because it's very detailed simulation. You can do a simulation of a whole city, but it's quite expensive and you probably don't want to do that all the time. So we thought with Karth or Thomas Thomas Lipsky from the Lulin technical university we thought, okay, so we have this understanding of the great model CFD on, on the near. There's plenty of other models being used, which I also do to my personal career and other developments previously, I have known we should like broaden it. So, so this is why in this in this chapter, we take the reader into a journey. First we try to discuss what. Is a fire mission. And there's a great chapter in the handbook about that as well. Like what is a fire? What does it emit? What can you expect from it as a source of heat and smoke, then we go through multiple types of of models with growing complexity. We start with something that's called the box models. Where you just assume a whole space is just one thing and you average things out within it. And that's the, that's probably the simplest way you can model contamination within an area, but you're. You are constrained by the size of the box. So, so it works only in, in certain scenarios. Then we go into Gian plume models where you have a single equation, AIAN distribution equation that allows you to calculate. If I admit this amount of smoking here, given that PSIC conditions around me, wind blowing in this direction, how much will go like 500 meters AF away, a kilometers, five kilometers away, 10 kilometers away. You can calculate this distribution. Now the problem with this is, is a very simple, easy calculation. It's just one equation you solve. You assume that the weather is not changing. Like, you know, you have one wind direction, one wind velocity, and it's constantly changing. And the bigger scale you go, like if I model a vehicle on a car, That's probably okay-ish to model it like that. But if you model like McMurray fault fire, where you have hundreds of square, hundreds of thousands of [00:25:00] square meters burning together, and the plume will take days to reach a different place in the us. You cannot model it like that. So you need to take this different things into account. So we go into more complex models there's models. I, I love them. They're called puff models where you it's more or less like Gian plume model, but you emit puffs of your fire and you model where the puff will go. So let's imagine. And each hour of a fire is a single puff and you just measure, okay, this puff goes here. This one goes here. This one goes here. And based on that, you, you have a more or less. Overall image on, on where the smoke will go. Then you can go into very complicated models. Laurian particle models, where you emit Laurian particles into, into three dimensional setting and you track where they go with allows you for very high, detailed investigation or where the smoke will go. and because of howing particles work, you can add chemistry to them. It's you can play a lot with them and ULA in models where you basically do more as a CFD of a, of a continent where you can really model the dispersion with a, with a complicated topography, complicated Windfield weather. At the cost, obviously it's not easy, but you can do that. So you have a hierarchy of, of models that you can use for a particular problem at hand. And of course, CD, which we many of these models, like there's their weakest thing is the nearfield, like what's happening directly near to the fire so that we cover with the CFD. So if you would like. Learn about this, the, the, the, the chapter and the handbook would be just for you. do you need this immediately in your life? I'm not sure, but if a day comes and you will need it, it's there waiting for you. So there's also a point of having a handbook. So if you, one day, find out yourself in the need for modeling things like this. Here you go. It's all there. Yeah. That's awesome. Yeah. Gus Gagliardi: I think it's stunning rooting through your chapter and just like skimming through a little bit. How many modeling examples are in this chapter that you produce? I just was thinking about how much time it must have taken to even a symbol, all, all of these like different modeling examples and all that. I was like, man, I've seen CFD before and I saw like some of those. Like the cutouts and the nice renderings and like artistic renderings of the wind cityscape and stuff, which was neat that I'd seen from something you presented before. But lots of great. It's not just. Text. It's like a beautiful imagery of modeling and, and a lot more information and charts and, and, you know, distributions for what's happening with this material. Wojciech Węgrzyński: So thank you very much. We, we wanted it to like if, if this is the first and only piece of research, you. On this specific topic, modeling environmental impact of fires. We wanted it to at least give you a fairly complete overview. Obviously we're talking about a whole field of science. There's hundreds of people writing papers of that. There's dozens of models. We, we were, it was even, it would, it would be even impossible to give a list, a complete list of models, not, not even to go and, and, and discuss them. So we focused on the ones that we knew are most popular or the ones we had some experience in. I mean, it, it is not an exclu exhaustive list. I, I guess, at, at some stage we'll build up on that and then present a more complete image. I think for, well, it took a few months of work. So for the time associated to make this chapter happen, I think we did a, a fairly good work completing all of this together, compiling it into, into one one piece of content. Gus Gagliardi: The chapter that that now is, is in the hands of engineers to. Yeah. So like how long did it take to like physically write it? Because I've been doing more technical writing recently and I'm so bad at it. I'm not good at all. and so I was just looking at this document and how like, Nice and polished. It is, and like the, the terminology and everything flowing and having nice little poetic phrasing in there. And I'm like, this would take me forever to write this. I can, I can tell you, let me find a manuscript folder on my, yeah, from the first draft till the one that we've sent. To [00:30:00] Brian. It was four months of work. Wow. Yeah, it was four months. I remember quite vividly. I I've spent my entire Christmas break reading literature and, and writing that it was fun. Wojciech Węgrzyński: Like 10 hours a day reading it. Oh my God. And writing, I like this. It's not it was not Pain. I, I, I, to some extent enjoyed, enjoyed it. It was nice to learn. The more pain comes when you have to like rephrase stuff and then put it into context. So, yeah, it, it was few months. And then obviously it was like two years in editing, you know, many people having it in their hands. Criticizing making changes, editorials and, and stuff like that. So the final product is a product of, of the work of many people. And it's not something you just go in and ride overnight, but yeah. Okay. Just writing it was months . Wow. That's incredible. That's cool. I don't think I've ever written anything that should have taken months in months. Gus Gagliardi: oh, I mean maybe a term paper as a student that I put off for too long, took me months to write, but I guarantee I wasn't writing that whole time. No, no. It's like, and I don't think I would have time to write it now again with the podcast on, on the, with the podcast project on my back. So I'm not sure if I'll ever author another. Piece like that. Well, maybe I will. We'll see. I'm sure you will. I'm sure you will. Maybe you'll get that patron one day and then you'll be able to outsource some of this editing but no I wanted to talk about like, it's such a complex process of, you know, Just like, I'd like to talk with you about just like some of the basic factors for like these modelings, but I know that that's just like, what's the basic factors of fire, which, you know, but also a topic I'd like to discuss with you is just like, so if we. Had infinite computing power mm-hmm like, what would we be able to do with these like models? You know, like a CFD for a whole city. Like if you could like model whatever, pick a reasonable sized city, but if you could model a reasonable size city and you had infinite computing power, could you get a, like a reasonable approximate approximation of like, Wind distribution of pollutants over a city from a fire. Wojciech Węgrzyński: I mean, like. I was seeing you having some examples of the different mm-hmm zone modeling and like near and the, the different compartments. But yeah, I just wanted to ask that. So my brain always jump. So what's the extreme, yeah, we, we, we don't have to go into abstract thinking, I, I, I think I can give you examples of, of citywide simulations, because we are actually doing them right now. Maybe not on a moderately size city, but on like a square kilometer of a city which is like quite a large chunk of a large city. So, so it takes us using our 128 cars of 128 CPUs. It takes us 24 hours to, to simulate a fire with all the distributions around it. So. It's not it's not something that will come in the future. It's something that we will already have. It's just not, not that many people are using that yet. If you wanted to seem like what would we do if we had crazy amount of power and like infinite infinite resources. I'm not like you can spend whatever amount of resources you want to increase the fidelity of your simulations. You can always use the smaller resolutions of your mesh. You can always use more complicated models. Does it translate to a better simulations? Not necessarily it's it's not such a direct link. I mean, it it's, it's a complicated, I'm actually gonna have a whole podcast episode with Jason Floyd about that, like in a month. so there's an, an, the answer is, is it's complicated, but not so easy. One thing that we like the, the. Issues are with the problem definition, not with the solution. You know, if you think about wind, like what's wind, like what direction, what velocity, what gusts, what we, we there's even a thing called the atmospheric stability. And based on that, you get different wind profiles. If you have a sunny clear day, or if you have a very. Cloud layer you'll have completely different atmospheric conditions. In, in those two days, you can have a wind in the winter. You can have a wind in, in the summer. So, you know, the, the amount of different wind context you can run into is, is endless, like in endless amount of fires you can. So if I had an access to infinite Computational power. [00:35:00] I would do infinite number of simulations, like concurrently to each other to really work out probability distributions and see a risk based image of on how Wind and fire go together. Like I would love to know with probability of this amount of percent, the wind impact will be this. And with this probability, it will be like this. And if the wind is extreme, but the probability is very low, the impact is extreme. Or maybe it's not, I don't know. Maybe with the wind that is very highly prob. Low velocity flow that occurs every other day. Maybe the impact is the biggest. I don't know that it's something that we're currently actually researching in, in a project that we're carrying at ITB. And we're somewhere in the middle of it. We are in the numerical calculations now to really measure. Impact of wind different types of wind, different, different directions in our context on how the consequences of the fire in an urban settlement are. And then we'll be able to, to say to what extent extended this something important or, or not based on risk. So yeah, I would, I would spend. Infinite resources on being able to do risk. not necessarily, you know, doing the fanciest simulation. I can. Mm, that makes sense. Yeah, I guess that's the whole thing is like understanding the very fluid and variable nature of the, the wind and just how quickly things can change the probabilistic. You know, kind of distribution of what could happen and the dispersion of the pollutants, I guess that makes sense of, you know, You know, like, do we even know enough about like the way that the wind and the atmosphere to even make that model? Yeah. Even if you had infinite like resources you know, like you're saying the valuable use of those of that. I I'll give you. I'll I'll give you for a context, a nice example. Like a few weeks ago, there was a severe drought in, in, in Europe heat wave. And there was like one of the hottest days ever in, in, in UK. They had a massive number of fires in London that day, like massive number. Like they, they compared it like it was the worst days. Sinces world war II in London in terms of the amount of fires. Wow. And because I'm involved in the biolife project I'm on the WhatsApp there. And there was a discussion there, like, and Gilman was mentioning and the wind was like very low that day, like four meters per second. And I checked it for London and it seems to be somewhere around the average or median wind and We understand, or we know that stronger wind usually leads to worse outcomes of fires. Like fire can spread, can grow bigger. It's it's usually connected with the worse outcomes. So if on the west day, since world war II, we had wind that was like around 50% chance and it was a wind that. Possibly not contribute that much to the damage. Like it could have been much, much worse with the worse wind. And if the probability of that was 50%, we essentially won a coin us, you know, like if it was not, the outcomes could have been so, so much worse. So this is why we need to. Understand that, and then be able to, to model that, to predict that because if this time we won a coin, us, what's gonna happen on the next worst day. Since world war II, will we lose the coin us? And how horrible will it be? What should we. What should we be ready for? Like, do we understand that as a society? I don't think so. So to, to gain insight into these questions, you first have to solve the fundamentals, which is how do you model them both together, wind and fire. Gus Gagliardi: Yeah. And that's what we're trying to do. Yeah, that's awesome. I like that real world context that Shere providing, you know, I think that's something that over the, like the history of our discipline has always been such a useful teaching tool and just way to ground the importance of what we do. You. It seems like society. It's very easy to forget, you know these tragedies when you exist, you know, most of your daily life is not impacted. And then you'll see a flash of something like this on the news. Mm-hmm like what you're just saying about London and. It having its worst day for fire since world war II. And it's like, you know, when you can bring to mind something so visceral like [00:40:00] that, it really has a great brings home. The meaning of like what we do and Notre Dame and gr fell. I mean, two tragedies that. They're still talking about to this day. I mean, they're still litigating Grandville. It would've happened in like 20 17, 20 16, something like that. Yeah, I can't remember, but it's just incredible how much impact and cultural significance that these fires and this subject has on people and it just kind of. Goes under the radar for the culture of how we exist. We just kind of forget about it. Go back to, we are dealing with very real problems in fire, like we're in. I mean, it, it, in a way it is abstract in a way it is something very. Weird complex difficult to understand. You start to realize the complexities, they, they prevent you from answering most of the questions usually, but in the end you have down to earth problems like real buildings that burn down real environments that suffer real people that suffer and, and yeah, that's what, that's why we are doing this difficult work to. To, to, to help that and, and, you know, being down to earth and being able to relate the, the science to the real world problems. I think it's an engineering science for a reason. Yeah. We, we have to solve the problems without knowing everything first. Yeah. So I feel like I you've talked, you've covered it pretty well, but just like, so why. I guess I'll just ask, instead of trying to put words in your mouth. Yeah. Why, what do you find compelling about like wind engineering or like the computational aspect of wind engineering or trying to be better about not like asking fully loaded questions and just like, obviously pushing my thoughts or opinions on people. When I am trying to do an interview. It's cool. Yeah, I, I, I like computational wind engineering is is something that I find. Interesting. I mean, we are using the same tools for, for fleet mechanics in, in fire safety engineering and in computational wind engineering. But the culture is very different. Wojciech Węgrzyński: They approach their problems in a different way. Like you have different scales in, in, in space. For example, like in wind engineering, you would consider a building and you can go away with two meter mesh on the building because it's a big block. But if you consider fire you, like, you need to model like these tiny details that will influence the fire. So here we, we are in a kind of different world than when wind engineers in terms what we are expected from our models to be in time scale. In wind engineering, you can most likely go away with with steady state simulations, something you never see in fire, because fire is a transient event. You have to like the time, the time aspect of a fire is fundamental to the fire, to the safety to E everything happens on the timeline. In winds, not, not really. It's like probability and just a single, single thing that happens at the time. So, so you go away with steady. So in, in the end, I mean, the tools are the same. I mean, we're also talking about building, so the thing you're modeling is the same, but you're doing it in a different way. And. This is compelling. You know, if you are a, if you're a guy who's been doing fire modeling, they're all professional career, you know, building these buildings, putting fires inside modeling, HVC systems, smoke control systems, doing the same thing over and over and over again, and then comes someone and tells you, now you have to do it. Like I forget about this interior. It's not relevant. It's, it's kind of refreshing, you know, to do something in a completely different way. And when you try to combine both, that's where the magic starts because you cannot simply combine them. Like you cannot put a fire analysis inside of wind analysis. It will not work. It, it it's, it's, it's a different thing. You cannot just drop wind randomly on your, on your fire. By ex you just extend the domain by 10 meters and drop wind. It's not gonna work. It's not wind that you're modeling. It becomes pretty interesting when you try to model the interface between them. It's not so simple. And I, I mean, I, I like dealing with difficult problems, so I, I really enjoyed being exposed to this one and trying to maybe not solve, but at least Try to work in this difficult setting. So yeah, that, that is rewarding and compelling and interesting for sure. For me using the, the fundamentals of computational wind engineering in fire safety engineering. Gus Gagliardi: Yeah, I think that's awesome. That's funny that you're like, oh, well, it seems like you guys are playing on easy mode over here with [00:45:00] steady state equations and yeah. You know, just like, I mean, I know it's a different set of problems, but, but then again like, and they can look at us and they, they, they can Ask us, like what's your time steps? Wojciech Węgrzyński: What's your what, how, how do you solve the, the chemistry of fire? Oh, we simplify that. Oh, you are playing easy mode. You're simplifying it. It way too much. They do take significant care in, in boundary layer problems, which we all. Like not everyone at ologists boundary layers in, in fire safety engineering yet to solve with boundary layers in mind when you're solving your flows. And these, these guys would be very serious about them. So, so it's like we oversimplify something horribly in fire as well. That is very exotic from the view of the other field and vice versa, I guess, I guess that's with the, every field of engineering, the users model. Right. Yeah, that's definitely true. Gus Gagliardi: Yeah. We just know the set of parameters and the distributions that we've simplified our equations around and, you know, you can't account for everything. So that makes sense. Well, I wanted to just ask you to zoom out a little bit and just speak more broadly about your career experience and just ask you like, you know on top of this endeavor you had going, what kind of trends have you been seeing just in your professional career? Wojciech Węgrzyński: It could be in the lab or in your project work. I, I guess I can talk broadly about, Hm, fire engineering as I view it. One trend that is really emerging is, is artificial intelligence. And. it's it's a thing that's in one way it's a black box. No one really understands how it works. It opens a whole world of possibilities that you would not even imagine without it yet. It's difficult to, to handle interpret and make sure that you have it under control when you're using it. So. It's definitely something growing and it, it will be growing and it will be amazing in the future, but together it's gonna be a hell of a challenge, you know, to make sure we are doing it in a great way. Like, think about how people can misuse CFD. Without understanding it and then multiply it by a hundred. That's how that's how difficult the AI can be if you, if you misuse it too much. So, yeah, it's, it's, it's a challenge, but it's an emerging trend that I see more and more in the years. And there are great people working on ITZ last year in Clemson. There's CNN, Wongan in Hong Kong, protecting university and many others. Who are carving the path for everyone else in, in fire to, to use these magnificent tools, you know? So yeah, that's, that's a trend for sure. Yeah, it's so wild. I you're right. I mean, I think AI is just in such the early days, you know, I was looking at like Microsoft outlook documentation and I was looking, they had like little e-learning and I was looking through their courses yesterday, looking for how to do something. And like they had. Like 80% of their documentation was about like, or their little courses were about AI. And it was like, what really is this? Why is it like, like how to, how to create a culture within your company? That's AI ready? And like all this talk about AI and I'm just thinking, as you're saying this, like this is coming and it's going to be a huge part of probably like society. Within our lifetimes. And then the next, probably, I don't know how long wouldn't hazard a guess, but I mean, guess if we don't screw up, it's going to be magnificent. Like you will like if we make it work and validate it and make sure we are using the correct tools for correct problems, AI could take over significant amount of repetitive and Non-critical tasks, fire safety engineers are doing. To allow them to focus on the things only they can solve, you know, viewing, building as a holistic sociotechnical system, right? No one, but fire safety engineer can do that. No algorithm will ever be able to do that. You need a human being with a great understanding of fire building building physics to comprehend. And we will meet these engineers on the same end. You don't want these engineers to focus on simple things that can be solved by an algorithm. So if we can find this beautiful golden center of having the tool, not misusing it and benefiting from it fuel. It would be a beautiful world. [00:50:00] I'm just not sure if we can get to that point before we either break it or ban it, you know? Gus Gagliardi: So yeah. Well, I'm a, I'm a cynic by nature and all I can think about is your commentary in your chapter about the error percentages before we developed some of the more. Modern models for CFD and how it was like 20 to two to 200% or something. Yeah. You know, scatters on. Yeah. But I can just, I don't know. I think that. Maybe I'm just cynical for human nature, but about how people will use a tool with that kind of horsepower behind it. But I'm sure just as in everything in life, there will be people who do it the right way and people who do it the wrong way. Exactly. Yeah. And that's at the same time, it's, it is one of the biggest opportunities and perhaps one of the biggest challenges we have, you know, because we know it's powerful. Wojciech Węgrzyński: We know you can use different like a, a iOS of course, just a name. Tons of different techniques and tools. And it's just, just, just a catch phrase. It's wider than CFD. Even like it, it has multiple flavors, multiple ways how you can implement multiple places in which. You can use computer to help you understand your data sets and problems at hand. So we really need to learn how to use it. We need to learn how to control it. We need to learn how to know that the predictions of it are credible or not. This will be very difficult to solve, but if we get there, it's gonna be fun. Yeah. Yeah, I'm sure we will gotta figure out how, how I, how we fit into that. Gus Gagliardi: But it sounds like you got a good idea with still providing that critical large scale oversight for the, that can't easily be reproduced with the algorithm. Yep. But yeah, I guess just thinking about like What kind of resources do you like to use? Wojak it could be professional or I'd even take a non-professional podcast recommendation. If you like to listen to podcasts or whatever you'd like to offer up to the viewers. Or if you've been watching something good lately, I don't, it's up to you. Dealer's choice at this point. You've done outstanding so far. So yeah. Cool, man. Shameless plug. Like there's the reasons right now, you know, I produce it. Wojciech Węgrzyński: it's, it's a great reason. But if you ask me where I get my resources, I I'm a scientist. I, I mainly rely on scientific papers which is very difficult to recommend to people who are non scientists, because you will be very frustrated by the way, how they are written and their hard to understand and comprehend. It's very rarely you find an answer to a problem in your paper, in the, in the scientific papers. So yeah, that's what we scientists have to work with. And I guess there's a. Space for people like Gus, me and others who try to, to build a bridge between engineers and scientists. So there's, there are credible journals, fire sector, journal, fire technology, which are great sources of knowledge, inspiration. As I said, difficult to, to comprehend that points. And and obviously behind the paywall, I can go whole day about how paywalls are destroying the scientific environment and how much I had hates that. But yeah, that's, that's how it is my. I really I think it benefit a lot from being a member of like SAP and IFSS organizations. These memberships like give me the, the ability to be part of engineering community and what they produce is, is absolutely outstanding. And I must say I learn more from being part of their projects, like being part of committees, being part of even, you know, writing that hand. I would never, never learn that much about modeling. As I did, when trying to summarize my knowledge and write the, the handbook chapter and the same goes into committees. If you join a committee and you have to work at a problem and try to convey that knowledge to others, you learn so much your own on your own. So. Not just consuming content and knowledge, but trying to create new knowledge, maybe a best way to, to gain new knowledge. So I would absolutely recommend participating in in the efforts of this bodies and Possibilities are endless because the needs are so huge. There's always a committee to join and participate. So, so these are these are great things. And outside of firearms, outside of engineering, I'm a huge fan of, of fin and smart, passive income podcasts. That is an amazing ecosystem of, of very positive [00:55:00] way of thinking. About entrepreneurship and just life in general, it I've gained so much from listening to patents. He's been an amazing mentor even though he I've never met him, he doesn't know about my existence. So I view him as, you know, a God in the podcast world, but yeah, it's, it's, it's been I I'm sharing, I I'm on his journey. For years now. And I enjoy every step of that all the way. I highly recommend smart, passive income and, and just Google path. You'll find him. Awesome. Well, I appreciate that Woj. I feel like that's a nice, neat bow on the podcast. I thank you for coming on. That was awesome. Yeah. Thank you so much guys. Gus Gagliardi: Looking forward to the next one. Sounds good. Thanks for listening. Everybody. Be sure to share the episode with a friend, if you enjoyed it, don't forget that fire protection and life safety is serious business. The views and opinions expressed on this podcast are by no means a professional consultation or a codes and standards interpretation. Be sure to contact a licensed professional. If you are getting involved with fire protection and or life. Thanks again, and we'll see you next time.

Last summer, the European Commission published a proposal for recasting the EU Energy Efficiency Directive (EED), aimed at further stimulating EU efforts to promote energy efficiency and progress towards achieving climate neutrality by 2050.Heating and cooling play a significant role in the Union's ambition to transition to a clean and carbon-neutral economy. In the EED, a particular focus is put on district heating and cooling, where the definition of efficient systems will gradually be tightened to move away from fossil fuel-based systems. In cogeneration, the aim is to introduce additional criteria for specific emissions in high-efficiency cogeneration (270 gCO2/kWh).These proposed measures in the recast EED should be seen alongside the new targets proposed in the revised Renewable Energy proposal for including renewables in heating and cooling (at least 1.1%) and for district heating and cooling (2.1%), which aim to ensure wider use of renewables and waste heat in such systems.The energy industry expressed some concerns for the new definition of "efficient systems" and its impact on district heating systems, especially those based on natural gas high-efficiency cogeneration. They claim that for existing efficient district heating systems, an adequate transition period should be introduced to adapt to the new requirements, in order to avoid these systems from suddenly losing their status.District heating is not the same across the Union, since it largely depends on regional and local conditions and is therefore mostly used in the EU's coldest countries. During the open public consultation carried out by the European Commission, several energy industry stakeholders expressed their concerns that the current goals of increasing the share of renewables can be seen as a challenge for Member States that have decided to develop heating systems as an effective way of ensuring heat supply while at the same time reducing the emissions of district heat by replacing coal with other fuels like natural gas.Relisten to this EURACTIV Virtual Conference to discuss the new definition of efficient district heating systems in the EED proposal, and how stakeholders can best cooperate to achieve cost-effective decarbonisation.

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Nearly three decades after the end of apartheid, South Africa continues to struggle from high levels of poverty and unemployment. Ostensibly to rectify this, the ruling African National Congress (ANC) has advanced a policy framework of "Black Economic Empowerment" (BEE), which identifies disadvantage on the basis of race and allocates benefits accordingly. David Ansara speaks with Dr Anthea Jeffery, Head of Policy Research at the Institute of Race Relations, about the ideological underpinnings of BEE, and why it has led to vast capital accumulation for a small, politically-connected elite. Dr Jeffery proposes an alternative solution: "Economic Empowerment for the Disadvantaged" (EED). Under the EED policy, empowerment interventions would be made on the basis of socio-economic status, rather than on racial grounds, with the private sector being incentivised to play a more active role in the distribution of welfare. TIMESTAMPS (0:00) Intro (0:50) Understanding BEE and its origins (7:25) How BEE enriches the elite and hurts the poor (10:07) An alternative model of empowerment (20:34) The role of the state (23:11) Existing forms of welfare distribution (25:45) The role of business (30:32) Low-fee private education (32:38) Overcoming political obstacles to EED (37:19) How decentralisation improves choices (39:26) Why BEE can't be fixed (44:54) Conclusion

"VACCINATIEPASPOORT OPMAAT NAAR WERELDWIJDE CONTROLEMAATSCHAPPIJ" Vera Sharav is oprichter en voorzitter van de Alliance for Human Research Protection (AHRP), een netwerk van medische professionals en leken met als doel om het recht op medische vrije keuze te waarborgen. AHRP richt zich met name op het naleven van de Eed van Hippocrates, de Code van Neurenberg (https://nl.wikipedia.org/wiki/Code_van_Neurenberg) en de Universele Verklaring over Bio-ethiek en Mensenrechten van UNESCO. De Code van Neurenberg werd na de Tweede Wereldoorlog opgesteld om te voorkomen dat mensen worden blootgesteld aan medische experimenten tegen hun wil, zoals onder de Nazi’s gebeurde. Het eerste punt uit de Code stelt: “De vrijwillige toestemming van de proefpersoon is absoluut noodzakelijk.” Ook dienen mensen die worden blootgesteld aan medisch onderzoek voldoende te zijn geïnformeerd. Deze twee richtlijnen vormen samen het principe van “informed consent”. Volgens Sharav wordt in de huidige vaccinatieprogramma’s niet aan deze voorwaarden voldaan. Zij wijst erop dat de vaccins slechts een tijdelijke goedkeuring hebben, onder noodwetgeving, en dat nog onvoldoende data bekend zijn voor definitieve goedkeuring. Dit betekent dat mensen die nu het vaccin krijgen meedoen aan een medisch experiment, terwijl ze dat niet beseffen. De gevolgen van de vaccins op langere termijn zijn zeer onzeker, stelt Sharav: het gaat om technologieën die nog nooit eerder op mensen zijn toegepast. Bij dierproeven bleek dat dieren die het vaccin hadden gehad bij hernieuwde blootstelling aan het coronavirus extra kwetsbaar waren. In dit interview met consultant en schrijver Elze van Hamelen, wijst Sharav op het gevaar van misbruik van de “openbare gezondheidszorg.” Een individuele arts is, op grond van de Eed van Hippocrates, altijd verantwoordelijk voor zijn handelen tegenover een patiënt. De relatie patiënt-arts is bovendien strikt vertrouwelijk. Maar “wanneer artsen gezondheidszorg-ambtenaren worden, zijn ze niet verantwoordelijk meer,” zegt Sharav. Er ontstaat dan een gevaarlijke situatie: onder het mom van gezondheidszorg kunnen genetische en andere experimenten op mensen worden uitgevoerd. Sharav, die als kind de Nazi’s ontvluchtte, wijst erop dat het uitroeiingsprogramma van de Nazi’s begon met gehandicapten en ouderen, en dat al deze mensen werden vermoord door artsen en ander medisch personeel in medische programma’s. Zij vreest dat de invoering van vaccinatiepaspoorten de opmaat zal vormen naar een nieuwe controlemaatschappij, die dit keer wereldwijd zal worden uitgerold, en die ertoe zou kunnen leiden dat ook nu een groep tweederangsburgers ontstaat die kan worden geïsoleerd of uit de weg kan worden geruimd. Government Consigned Israeli Population to be Human Subjects in a Massive Experiment (Vera Sharav) https://ahrp.org/government-consigned-israeli-population-to-be-human-subjects-in-a-massive-experiment/ Beware of Medicine Marching in Lockstep with Government, Personal Reflections (Vera Sharav) https://ahrp.org/beware-of-medicine-marching-in-lockstep-with-government-personal-reflections/ Pfizer, Israel, en het medische experiment (Elze van Hamelen) https://vanhamelen.eu/uncategorized/pfizer-israel-en-het-medische-experiment/ Nieuw Neurenberg (Elze van Hamelen) https://vanhamelen.eu/uncategorized/nieuw-neurenberg/ Why did so many German doctors join the Nazi Party early? (Omar S.Haque, et. al) https://www.sciencedirect.com/science/article/abs/pii/S0160252712000854 Schwab Family Values (Johnny Vedmore) https://unlimitedhangout.com/2021/02/investigative-reports/schwab-family-values/ Alliance of Human Research Protection (AHRP) https://ahrp.org/about/ Van Hamelen Research & Education https://vanhamelen.eu/ Deze video is geproduceerd door Café Weltschmerz. Café Weltschmerz gelooft in de kracht van het gesprek en zendt interviews uit over actuele maatschappelijke thema's. Wij bieden een hoogwaardig alternatief voor de mainstream media.

Nee`e US-Präsident hett Eed afleggt +++ Wedder mehr nee`e Corona-Fälle in Düütschland +++ Bremer schüllt FFP2-Masken op Freeschien kriegen +++ Keene Arbeitssteden bi Bremer Ruumfohrtkonzern OHB in Gefohr, seggt se +++ Bekritteln vun Schoolpolitik in Neddersassen +++ Dat Weer

Paul J. Wang: Welcome to the monthly podcast! On the Beat for Circulation: Arrhythmia and Electrophysiology. I'm Dr. Paul Wang, Editor-in-Chief. With some of the key highlights from this month's issue. Paul J. Wang: In our first paper, Demilade Adedinsewo and associates assess the accuracy of an artificial intelligence-enabled electrocardiogram [AI-ECG] to identify patients presenting with dyspnea who have left ventricular LV systolic function (defined as LV ejection fraction ≤35%) in the emergency department [ED]. Patients were included if they had at least one standard 12-lead electrocardiogram [ECG] acquired on the date of the ED visit and an echocardiogram performed within 30 days of presentation. Patients with prior LV systolic dysfunction were excluded. A total of 1,606 patients were included. Meantime from ECG echocardiogram was one day. The AI-ECG algorithm identified LV systolic dysfunction with an area under the curve [AUC] of 0.89 and accuracy of 85.9%. Sensitivity was 74%, specificity 87%, negative predictive value 97%, and positive predictive value 40%. To identify an ejection fraction less than 50%, the AUC was 0.85, sensitivity 86%, sensitivity 63%, and specificity 91%. NT-proBNP alone with a cutoff greater than 800 identified LV systolic function with an AUC of 0.80 by comparison. Paul J. Wang: In our next paper, Mahmood Alhusseini and associates hypothesize that convolutional neural networks [CNN] may enable objective analysis of intracardiac activation in atrial fibrillation [AF]. They perform panoramic recording of bi-atrial electrical signals in AF and use the Hilbert-transform to produce 175,000 image grids in 35 patients labeled for a rotational activation by experts who showed consistency, but with variability (kappa [κ]=0.79). In each patient, ablation terminated atrial fibrillation. A CNN was developed and trained on 100,000 AF image grids validated on 25,000 grids, and then tested on a separate 50,000 grids. They found in a separate test cohort of 50,000 grids, CNN reproducibly classified AF image grids into those with or without rotational sites with 95.0% accuracy. This accuracy exceeded that of support vector machines, traditional linear discriminant, and k-nearest neighbor statistical analyses. To probe the CNN, they applied gradient weighted class activation mapping, which revealed that the decision logic closely mimicked rules used by experts (C statistic 0.96). The authors concluded that convolutional neural networks improve the classification of intercardiac AF maps compared to other analyses and agreed with expert evaluation. Paul J. Wang: In our next paper, Kenji Okubo and associates examined whether late potential LP, abolition and ventricular tachycardia [VT] non-inclusive ability predicted long-term outcomes in patients with non-ischemic cardiomyopathy [NICM] undergoing VT ablation. The total 403 patients with NICM (523 procedures) who underwent VT ablation from 2010 to 2016 were included. The underlying structural disease consists of dilated cardiomyopathy (DCM, 49%), arrhythmogenic right ventricular cardiomyopathy (ARVD 17%), postmyocarditis (14%), valvular heart disease (8%), congenital heart disease (2%), hypertrophic cardiomyopathy (2%), and others (5%). Epicardial access was performed in 57% of patients. At baseline, the LPs were present in 60% of patients, and a VT was either inducible or sustained/incessant in 85% of the cases. At the end of the procedure LP abolition was achieved in 79% of cases in VT noninducability in 80%. After a multivariate analysis, the combination of LP abolition and VT noninducibility was independently associated with free survival from VT (hazard ratio, 0.45, p = 0.0002) and cardiac death (hazard ratio 0.38, P = 0.005). The benefit of LP abolition of preventing the VT recurrence in ARVD and postmyocarditis appeared superior to that observed for DCM. Paul J. Wang: In our next paper, Domenico Corradi, Jeffrey Saffitz and associates hypothesize that structural molecular changes in atrial myocardium that correlate with myocardial injury and precede and predict postoperative atrial fibrillation [POAF] may identify new molecular pathways and targets for prevention of this common morbid complication. Right atrial appendage [RAA] samples were prospectively collected during cardiac surgery from 239 patients enrolled in the OPERA trial. 35.2% of patients experienced POAF compared to the non-POAF group. They were significantly older and more likely to have chronic obstructive pulmonary disease or heart failure. They had a higher Euro score and more often underwent valve surgery. No differences in atrial size were observed between POAF and non-POAF patients. The extent of atrial interstitial fibrosis, cardiomyocyte myocytolysis, cardiomyocyte diameter, glycogen storage, or connection 43 distribution at the time of surgery, was not significantly associated with the incidents of POAF. None of these histopathological abnormalities were correlated with level of NT pro-BNP, hs-cTnT, CRP, or oxidative stress biomarkers. The authors concluded that in sinus rhythm patients undergoing cardiac surgery, histopathological changes in RAA do not predict POAF. They did not also correlate with biomarkers of cardiac function, inflammation, and oxidative stress. Paul J. Wang: In our next paper, Mark McCauley, Liang Hong, Arvind Sridhar, and associates hypothesize that obesity decreases sodium channel NAF 1.5 expression via enhanced oxidative stress, thus reducing the sodium current and enhancing susceptibility to atrial fibrillation [AF]. They studied a diet induced obese [DIO] mouse model. Pacing induced AF in 100% of DIO mice versus 25% in controls (P 20 ms shorter than the other sites, and/or induction of AF/atrial tachycardia during measurements. LVA ablation was performed in the LA-LVA patients during the follow-up period of a mean of 62 weeks, the EP test-guided group had a significantly lower recurrence rate (19%,11/57 versus 41%, 22/54, P=0.012) and a higher Kaplan-Meier AF/AT-free survival curve compared with controls (P=0.01). No significant differences in the recurrence, and AF/AT-free survival curves between PWI (positive EP test) and non-PWI (negative EP test) subgroups were observed. Therefore, PWI for positive EP tests reduced the AF/AT recurrence in the EP test-guided group. A stepwise Cox proportional hazard analysis identified EP test-guided ablation as a factor, reducing recurrence rates. The recurrence rates in LA-LVA ablation group and EP test-guided group were similar. Paul J. Wang: In our next study, Jinxuan Lin and associates assess whether simultaneous pacing of the left and right bundle branch areas may achieve more synchronous ventricular activation than just bundle pacing alone. In symptomatic bradycardia patients, the distal electrode of the bipolar pacing lead was placed at the left bundle branch area via a transventricular-septal approach. This was used to pace the left bundle branch area, while the ring electrode was used to pace the right bundle branch area. Bilateral bundle branch area pacing [BBBP] was achieved by stimulating the cathode and anode in various configurations. BBBP was successfully performed in 22 out of 36 patients. Compared with LBBP, BBBP resulted in greater shortening of QRS duration (109.3 vs 118.4 ms, P < 0.001). LBBP resulted in paced RBBB configuration with a DRVAT of 115 ms and interventricular conduction delay of 34.0 ms. BBBP fully resolved the RBBB morphology in 18 patients. In the remaining 4 patients, RBBP pacing partially corrected the right bundle branch block. Paul J. Wang: In our next paper, Ramanathan Parameswaran, Jonathan Kalman, Geoffrey Lee and associates recorded 2-minute long segments of simultaneous inter-operative mapping of endo- and epicardial lateral right atrial [RA] wall in patients with persistent atrial fibrillation [AF] using 2 high-density grid catheters (16 electrodes, 3 mm spacing). Filtered unipolar and bipolar electrograms [EGMS] of continuous 2-minute AF recordings and electrodes locations were exported for phase analysis. They defined endocardial-epicardial dissociation [EED] as phase differences of ≥20 ms between paired endo- and epi electrodes. Wavefronts [WF] were classified as single rotations, that is single wavefront, focal waves, or disorganized activity as per standard criteria. Endo-Epi wave fronts were simultaneously compared on dynamic phase maps. Complex fractionated electrograms were defined as bipolar electrograms with directional changes occupying at least 70% of the sample area. 14 patients with persistent AF underwent cardiac surgery are included. EED was seen in 50.3% of phase maps with significant temporal heterogeneity. Disorganized activity (endo 41.3%, epi 46.8%, P = 0.0194) and single wave (endo 31.3 versus epi 28.1, P = 0.129) were the dominant patterns. Transient rotations (endo 22%, epi 19.2%, P = 0.169, mean duration 590 ms) and non-sustained focal waves (endo 1.2% and epi 1.6%, P = 0.669) were also observed. Apparent transmural migration of rotational activations (n=6) from the epi- to the endocardium was seen in 2 patients. EGM fractionation was significantly higher in the epicardium than endocardium (61.2% versus 51.6%, P < 0.0001). The authors concluded that simultaneous endo-epi phase mapping of prolonged human persistent AF recordings showed significant EED marked temporal heterogeneity, discordant and transitioning wavefronts patterns and complex fractionations. No sustained focal activity was observed. Such complex 3-dimensional interactions provide insights into why endocardial mapping alone may not fully characterize the AF mechanism and why endocardial ablation may not be sufficient. Paul J. Wang: In our next paper, Andrew Beaser and associates hypothesize that intravascular ultrasound [IVUS] could accurately visualize and quantify intravascular lead adherence and degree of intravascular lead adherence correlates with transvenous lead extraction difficulty. Serial imaging of leads occurred prior to transvenous lead extraction using IVUS. Intravascular lead adherence areas were classified as high or low grade. Degree of extraction difficulty was assessed using 2 metrics and correlated with intravascular lead adherence grade. Lead extraction difficulty was calculated for each patient and compared to IVUS findings. 158 vascular segments in 60 patients were analyzed: 141 (89%) low grade versus 17 (11%) high grade. Median extraction time (low = 0 versus high grade 97 seconds, P < 0.001) and median laser pulsations delivered (low = zero versus high grade 5,852, P < 0.001) were significantly higher in the high-grade segments. Most patients with low lead extraction difficulty score had low intravascular lead adherence grades. 86% of patients with high lead extraction difficulty score had low IVUS grade, and the degree of transvenous lead extraction difficulty was similar to patients with low IVUS grades and lead extraction difficulty scores. Paul J. Wang: In our next paper, András Bratincsák, and associates sought to create the foundation of normative ECG standards in the young using Z-scores. 102 ECG variables were collected from a retrospective cohort of 27,085 study subjects with no known heart conditions, age zero to 39 years. The cohort was divided into 16 age groups by gender. Median interquartile range and range were calculated for each variable adjusted to body surface area. Normative standards were developed for all 102 ECG variables, including heart rate; P, R, and T axis; R-T axis deviation; PR interval, QS duration, QT, and QTc interval; P, Q, R, S, and T amplitudes in 12 leads; as well as QRS and T wave integrals. Incremental Z-score values between negative 2.5 and 2.5 were calculated to establish the upper and lower limits of normal. Historical ECG interpretive concepts were reassessed and new concepts observed. The author summarized that electronically acquired ECG values based on the largest pediatric and young adult cohort ever compiled provide the first detailed, standardized, quantitative foundation of traditional and novel ECG variables. Paul J. Wang: In our next paper, Jungmin Hwang and associates hypothesize that suppressing the late sodium current may counterbalance the reduced repolarization reserve in long QT syndrome [LQTS] and prevent early depolarization [EAD] and polymorphic ventricular tachycardia [PVT]. They tested the effects of selective late sodium channel blocker GS967 on polymorphic ventricular tachycardia [PVT] induction in a transgenic rabbit model of type two using intact heart optical mapping, cellular electrophysiology, and confocal calcium imaging and computer modeling. They found that GS967 reduced ventricular fibrillation [VF] induction under a rapid pacing protocol (7 out of 14 hearts in control versus 1 out of 14 at 100 nanomolar) without altering action potential duration [APD] or restitution and dispersion. GS967 suppressed PVT incidents by reducing calcium mediated EADs and focal activity during isoproterenol perfusion (at 30 nanomolar, 7 out of 12 and a 100 nanomolar, 8 out of 12 without EADs and PVTs). Confocal calcium imaging of LQT myocytes revealed GS967 shortened calcium transient duration by accelerating sodium calcium exchanger mediated calcium efflux from cytosol, thereby reducing EADs. Computer modeling revealed the inward late sodium current potentiates EADs in the LQT setting through providing additional depolarizing currents through action potential plateau phase, and increasing intracellular sodium that decreases the depolarizing sodium calcium exchanger, thereby suppressing the action potential plateau and delaying the activation of slowly activating delayed rectifier current, IKS. Suggesting important roles in the late sodium current in regulating intracellular sodium. Thus, the authors concluded that selective late sodium channel blockade by GS967 prevents EADs and abolishes PVT in LQT rabbits by counterbalancing the reduced repolarization reserve and normalizing intracellular sodium. Paul J. Wang: In our next paper, Pietro Lazzerini, Mohamed Boutjdir and associates, hypothesize that systemic inflammation per se can significantly prolong QTc during infection via cytokine-mediated changes in potassium channel expression. They found in patients with acute infections, regardless of concomitant QT-prolonging anti-microbial therapy, QTc was significantly prolonged but rapidly normalized in parallel to C-reactive protein [CRP] and cytokine level reduction. Consistently, in Torsades de Pointes cohort, concomitant acute infections were prevalent 30% despite only a minority (25%) of these cases were treated with QT-prolonging anti-microbials. KCN J2, potassium channel expression in peripheral blood mononuclear cells was strongly correlated to that in ventricles, inversely associated to CRP and interleukin one changes in acute infection patients. The authors concluded that acute infection, systemic inflammation rapidly induces cytokine-mediated ventricular electrical remodeling and significant QTc prolongation, regardless of concomitant antimicrobial therapy. Paul J. Wang: In a research letter, Christophe Beyls and associates examined the risk of bradycardia and critically ill COVID-19 patients treated with Lopinavir [LPV], a protease inhibitor of HIV-1, and Ritonavir [RTV], another protease inhibitor that strongly inhibits hepatic cytochrome P 450 [CYP3A4] activity in order to increase the Lopinavir plasma concentration. During the first month of the outbreak, patients admitted to the ICU with positive PCR for COVID-19 received LPV (200 mg)/RVT (50 mg) twice daily for 10 days. Bradycardia was defined as heart rate below 60 for a period of more than 24 hours. All patients were monitored 24 hours a day for all hemodynamic parameters, including heart rate with a five-lead ECG. Monitors were linked to a computerized system allowing to extract hemodynamic data. LPV/RTV plasma concentration was monitored using analytic method, combining high propensity performance, liquid chromatography and tandem mass spectrometry at 72 hours and every 72 hours. They prospectively included 41 COVID-19 patients who received LPV/RTV treatment. Nine or 22% patients experienced bradycardia. No patients had a pre-existing nodal pathology on the ECG on admission. Among the 9 patients with bradycardia, 8 or 88% were sinus bradycardia and one (12%) third-degree AV block. Causality may be considered as bradycardia occurred at least 48 hours after LPV/RTV initiation, bradycardia resolved after discontinuation or dose reduction and no alternative cause was found. Patients who presented with bradycardia were older, had a higher RTV plasma concentration and a lower lymphocyte count. In our study, no correlation was found between RTV plasma concentration, LPV plasma concentration, and mean heart rate at day three. No patient had bradycardia in the first 48 hours after LPV/RTV administration. For patients with LPV RTV plasma level overdose, the dose of LPV RTV was divided by two until the next dose. For the patient with third degree AV block LPV/RTV was stopped. None of the patients had any known cytochrome CYP3A4-inhibiting drugs. The authors concluded that the results suggest that RTV plasma overdose in elderly critical ill patients may increase the risk of bradycardia. Paul J. Wang: In a research letter, Emily Zeitler and associates surveyed cardiac implantable device [CID] patients. A total of 109 patients were approached to participate, nine declined. Most respondents were white (79%), male (60%) with a mean age of 73 years. The median number of correct responses to the 11 factual questions was six. Respondents held some common misconceptions. For example, 25% of respondents believe that FDA determines the cost of the device. Trust in the FDA was high; 67% of respondents agreed "I trust the FDA". Respondents mostly agreed "the FDA would not approve my device unless it was a hundred percent safe". Only 6% of respondents agreed, "we would be better off if there was no FDA," and a similarly small fraction disagreed with "when it comes to medical devices, the U.S. does the best job in the world at keeping people safe". Most respondents, 69% demonstrated fear of device recalls by agreeing with "if there was a recall of all are part of my device, I think I would be worried or scared." On average, respondents were comfortable sacrificing some privacy for device surveillance, 75% agreed with "once the device has been approved, the FDA should continue to monitor for signs that there are problems with the device even if it means that private health information about me is collected". Respondents seemed to believe that the FDA was risk averse; 56% believed that the FDA does not approve devices unless they're a hundred percent safe. This is in contrast to trends shifting the demonstration of safety to post-approval settings and expanding acceptable forms of data for regulatory approval. Paul J. Wang: In a research letter, Laura Rottner, Christoph Sinning and associates examined novel high resolution imaging system based on a wide band dielectric technology, and reports the first clinical experience of feasibility and reliability of cryoballoon [CB] occlusion tool as compared to fluoroscopic and 3D transesophogeal [TEE] assessment during pulmonary vein isolation [PVI]. In consecutive patients with symptomatic atrial fibrillation [AF], cryoballoon-based ablation was performed with a novel 3D wide-band dielectric imaging system. Pulmonary vein [PV] occlusion was assessed with fluoroscopy in 3D-TEE and concomitantly correlated with the novel CB occlusion tool. The endpoint was defined as persistent PV isolation verified by spiral mapping catheter recordings 30 minutes after the last CB application. A total of 36 (90%) of PVs in 10 patients with paroxysmal (40%) and persistent (60%) were analyzed. In all patients, a normal PV anatomy with four separate PVs was documented. Visualization via 3D-TEE was feasible in 80% septal PVs and 100% of lateral PVs. In 67% of PVs, total PV occlusion was confirmed by all 3 imaging modalities. In 17% of PVs, incomplete PV occlusion was initially demonstrated by TEE and 3D dielectric imaging, whereas fluoroscopy suggested complete occlusion in initial analysis. After repositioning of the CB at 3 PVs, complete PV occlusion was verified by all three modalities. In 3 out of 36 (8%), no occlusion was initially seen by any imaging modality, for which the CB was repositioned resulting in total PV occlusion as confirmed by all three modalities. Two out of 36 PVs (6%) were confirmed to be occluded via fluoroscopy in 3D-TEE, but not by the CB occlusion tool. There was only one out of 36 PVs (3%), which were confirmed to be included by the CB tool and 3D-TEE, but not by fluoroscopy. A negative and positive predictive value of 1.0 and 0.6 was seen when comparing PV occlusion by the novel occlusion tool compared to PV collusion, verified by fluoroscopy and 3D-TEE. Paul J. Wang: In a special report, Jun Hirokami, and associates aim to clarify the spatial correlations between fractionated potential detected by Lumipoint with non-PV trigger. They enrolled 30 symptomatic atrial fibrillation [AF] patients who underwent non pulmonary vein [PV] foci ablation. 4 patients underwent the first procedure, 17 underwent second procedure and eight underwent third procedure, and one underwent a fourth procedure. They highlighted the fractionated signal area in atrial muscle [FAAM] during sinus rhythm and atrial pacing, thereby producing a digital FAAM map. They retrospectively applied Lumipoint to 30 patients in order to clarify the relationship between FAAM and non-pulmonary vein [PV] foci. Non-PV foci were successfully identified in all patients. They identified four patients with multiple non-PV foci. Of these four patients, one had non-PV foci at the superior vena cava and left arterial anterior wall. One had non-PV foci at the SVC and LA bottom wall. And two had non-PV foci at the SVC and interatrial septum. They only analyze 30 non-PV foci unrelated to SVC because the SVC isolation was routinely performed for non-PVC foci at the SVC. In order to analyze the correlation between FAAM and location of non-PV triggers, they determined the cutoff points of peaks slider, which non-PV triggers were completely located within the FAAM in. The accuracy of predicting location of the non-PV triggers was summarized using area under the receiver operating curve, a UROC curve. The optimal cutoff point of peak sliders to predict the location of non-PV was determined by the Youden Index. The Youden Index established the optimal cutoff point of the maximum peaks slider was 7; sensitivity was 0.906 and specificity 0.770. The peaks slider 7 was the most accurate predictor fractionated signals location area to the location of non-PV triggers. (area under the curve 0.902). The mean area of peaks slider 7 was six centimeters squared or 4.3% of the atrium. The authors concluded that the proof-of-concept observational study demonstrated that novel visualization tool of FAAM map successfully identified non-PV triggers that did not induce atrial fibrillation and/or non-PV foci, which potentially serve as substrates for AF maintenance. Paul J. Wang: In a special report, Leslie Saxon and associates update their prior publication providing further detail on mitigation adoption rates for the entirety of the U.S. patient population with implanted cardiac rhythm management devices falling under FDA cyber security advisories from any device manufacturer. They also provided limited data on known cybersecurity mitigation adoption outside the U.S. They report a unique complication resulting for introducing firmware to already implanted devices. Discuss how evolving FDA policies towards firmware mitigation adoption may increasingly determine how and when updates occur. They found that patients under 50 years of age and those over 80 years were less likely to receive the software upgrades, and male versus females had greater rates of upgrades. The upgrade rates varied according to U.S. Region and date of implant. Resynchronization devices were less likely to receive the upgrade, as were pacemaker dependent patient. Those ICD patients initially falling under the battery advisers were upgraded more frequently. The number of advisory patients followed in clinic was a significant predictor for firmware upgrade adoption, particularly for pacemakers that were often upgraded in smaller size clinics. Overall, only 24% of devices for all groups, and 22% of devices not impacted by the battery advisory were upgraded. For Abbott devices, the home communicator cyber security vulnerabilities were mitigated with an automatic software patch that was updated using the Merlin network, and adoption rates were nearly a hundred percent. For the entire patient cohort with impacted pacemaker and ICDs, U.S. and global adoption rates remain low at 24 to 35% with a low rate of complications. Most reported complications for pacemakers and ICD were symptoms (transient palpitations, dizziness, or syncope) that resulted from the temporary change in mode to VVI or transient loss of programmer telemetry while performing the upgrade (pacemaker 0.05%; ICD 0.01%). Globally, a total of 9 pacemakers and 8 ICDs required replacement, as a result of performing the firmware upgrade due to irreversible reversion to a backup pacing mode and loss of defibrillation therapy (ICDs). Analysis of the returned ICD pulse generaotrs found at 7 cases, the cause related to a capacitor bond failure that was exposed only when extended telemetry as required by the upgrade. The failure mechanism was an isolated component failure in the remaining ICD. The programmer based test has recently been FDA approved and can be performed prior to firmware upgrade to identify ICD patients at risk for capacitor bond failure. A total of 256 ICDs were susceptible to loss of RF telemetry after receiving a firmware update, and this has since been mitigated with a software patch. For Medtronic programmers, the initial mitigation responses of cybersecurity advisory was to take the programmers off the network. The network connection was enhanced with one or more security protections provided to the programmers using a flash drive, so the programmers can now be secured from potential cyber intrusion when connected to the network. Medtronic ICDs are currently being upgraded. The upgrade is being provided to impacted patients automatically when the device is interrogated with the programmer during follow-up. Metronic is introducing upgrades in phased approach with all expected to be completed by the beginning of 2021. There are 9% or 55,000 ICDs under this advisory that cannot receive the update due to design or safety constraints. Since the 2017 Abbott advisories identify cybersecurity vulnerabilities in pacemakers and ICDs with the potential for exploits have been increased, including 2 additional FDA advisories issued for another manufacturer. Medtronic's connected communication product and implantable defibrillators in the past 12 months. The authors comment that a recent report and a smaller number of Abbott impacted pacemaker and ICD patients from Canada reported marked differences in mitigation adoption rates between pacemakers and ICDs. This was due to an increase incremental clinical familiarity and comfort with performing the updates as experience and education surrounding these issues evolve. The authors indicate that automating cybersecurity updates without process in place for determining safety, for alerting patients or clinicians that have been delivered, may also be associated with yet unknown risks. Newer generation devices and communication protocols may render cyber security, advisories less frequent as cybersecurity integration is considered an essential aspect of device design. Paul J. Wang: In a review article, Albert Feeny and associates discuss the use of artificial intelligence [AI] and machine learning [ML] in medicine, which are currently areas of intense exploration showing potential to automate human tasks or even perform tasks beyond human capabilities. The first objective of this review is to provide the novice reader with a literacy of AI/ML methods, and to provide a foundation of how one may conduct an ML study. The review provides a technical overview of some of the most commonly used terms, challenges in AI/ML studies with reference to recent studies in cardiac electrophysiology to illustrate key points. The second objective of this review is to use examples from the recent literature to discuss how AI and ML are changing clinical practice and research in cardiac electrophysiology with emphasis on disease detection and diagnosis, prediction, and patient outcomes and novel characterization of disease. The final objective is to highlight important considerations and challenges for appropriate variation, adoption, and deployment of AI technologies and practice. Paul J. Wang: That's it for this month! We hope that you will find the journal to be the go-to place for everyone interested in the field! See you next time! This program is copyright American Heart Association 2020. Thank you.  

Ever consider moving about the world in a nomadic fashion while running a business?  Well tune in as Iveta Zaklasnikova describes her life doing just that --the good, the bad, and all the in betweens. Bio Iveta Zaklasnikova is an EED - entrepreneur, expat and digital nomad. She specialises in helping expat women turn their skills and talents into a purposeful online business so that they can ditch the 9-5 and live a life of freedom.   Iveta was born and raised in the Czech Republic.  She got the urge to move abroad at the age of 21. Since then she has lived in 11 countries and counting. Through it all she has learned that people are the same everywhere around the world - they just want to be happy and have a good life. 

SPEED. We’re talking about real speed. Florida speed … light-pole-to-light pole spee-EED! Of course, our guy, the young'un, HOLLYWOOD Brown, joins Truss Levelz. Say hello to Hollywood, as he gets into it all, including explaining how Florida Pop Warner is just different, with thousands in the stands and the whole hood coming out to rock with their guys. His rise is unique: With no D1 offers, he told his mom he’d go JUCO and wouldn’t come back without a D-I scholarship, and … He. Did. That. Then he talks going crazy at Oklahoma, including setting the school record for yards in a game and playing with two Heisman QB’s. From there it’s off to the league, to what it’s like being boys with the MVP, why he loves playing for the Ravens and him popping off his rookie year. Oh, and one more thing —  you do not want to play Hollywood in any video g See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.14.297135v1?rss=1 Authors: Wright, H., Aylwin, C. F., Toro, C. A., Ojeda, S. R., Lomniczi, A. Abstract: Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1, a puberty-activating gene, is a key target of this silencing mechanism. Using a gain-of-function approach and a systems biology strategy we now show that EED, an essential PcG component, acts in the arcuate nucleus of the hypothalamus to alter the functional organization of a gene network involved in the stimulatory control of puberty. A central node of this network is Kdm6b, which encodes an enzyme that erases the PcG-dependent histone modification H3K27me3. Kiss1 is a first neighbor in the network; genes encoding glutamatergic receptors and potassium channels are second neighbors. By repressing Kdm6b expression, EED increases H3K27me3 abundance at these gene promoters, reducing gene expression throughout a gene network controlling puberty activation. These results indicate that Kdm6b repression is a basic mechanism used by PcG to modulate the biological output of puberty-activating gene networks. Copy rights belong to original authors. Visit the link for more info

Binnen de GGz is ook veel in beweging rond vanuit je hart werken en meer aandacht voor iemands mogelijkheden in plaats van problemen. Remke van Staveren maakt zich daar hard voor, persoonlijk en met veel aandacht voor de rol van de professional.   Een zeer bevlogen psychiater die zich heel duidelijk uitspreekt en steeds haar bescheiden rol benadrukt. Het hart moet terug in de zorg! Ze schreef vier boeken waarvan Hart voor de GGz en Hart voor herstel haar het meest aan het hart liggen. We praten over je eigen cirkel van invloed, klein beginnen, doen waar je zelf in gelooft, zelfsturing, het verschil tussen de specialistische en generalistische GGz, mensen die niet in een loketje passen, wachtlijsten (Oplossen!). Én de toekomst van de DSM, wat voor Remke zeker NIET de bijbel van de psychiater is.   Ken je de van de Eed van Hippocrates? Voor Remke is dat een belangrijke drijfveer om in te gaan tegen 'zo doen we dat nu eenmaal'. Ze geeft een aantal mooie voorbeelden hoe je grote veranderingen kunt bereiken door klein te beginnen, bijvoorbeeld door een verplicht formulier niet in te vullen.    In de podcast komt het niet aan de orde, maar mede door de inzet van Remke en actie #stopstigmatiserendestockfotosggz is de beeldbank van het ANP in juli 2020 aangevuld met realistische en respectvolle beelden van de GGz. Geen prikkeldraad, separeers of beenklemmen meer. Beelden over de JeugdzorgPlus komen volgens mij uit dezelfde beeldbank dus ook voor de jeugdzorg heel goed nieuws!   Het was een mooi gesprek met een prachtige afsluiter: "Je kan meer dan je denkt, je kunt meer bereiken als je maar in jezelf gelooft. Ik hoop dat professionals meer in zichzelf gaan geloven en ook in actie komen voor betere zorg. Voor onze client, maar ook voor onszelf en elkaar!"   Dank je wel Remke!  

You may not be able to move about as much, but keeping active is essential to maintaining your immunity and finding a sense of calm amid uncertainty. - w>ftd.fqd;ySJRw>f[l;w>f*JR'D;w>ftd.fql.ftd.fcs h e h.f rR*hRxD.f0J'.f eeD.fcd*H>f-wDq>w>fe h.fvDR?

On continué la tournée des dirigeants de notre MEDIA FC avec pour cet épisode, le Président Brisbois ! Ses meilleurs souvenirs, son plus beau but, un retour sur un MFC vs EED et les chroniques du Kop Balard qui reviennent sur le premier déplacement officiel de l'Histoire du Kop... Bonne écoute les Balzouzes !

Carey Sperry:                   In this episode I speak with my good friend and business strategic Alliance firm partner Phil Graham, about how to leverage social media paid ads into 2020 and beyond. There are so many golden nuggets Phil gives us here, but a couple key takeaways I think you'll find helpful and interesting is how important it is to keep in mind the intent of the prospect of customer, and intent differs by platform. Many people have a different expectation of the experience and their intent is also different while on the Facebook platform versus when they're on the Instagram platform. Carey Sperry:                   So Phil explains how when you understand this and keep it in mind, it helps you to craft your paid ad to align with the viewers mindset, which ultimately he sees paid ads are higher than the ads are crafted with consideration of intent than when brands don't align their ads to the intent. Another key takeaway is he teaches us to approach ads with both a system and a delivery of value. Most people don't have a system for their ads, nor they do. They deliver value in their ads. They just sell right off the bat. He says, "It's like going to a party. You might be walking up to a person and saying, 'Let's get married.'" So you probably heard that analogy before, but most people out there do not keep that in mind. When they do paid ads, they just sell right off the bat, turn off. So he talks about what he means by system and also his EED framework. Educate, entertain, and differentiate this framework and how it will help make your ads convert way better than the majority of people. Carey Sperry:                   Hi everyone. Carey Sperry here. Today we have Phil Graham and we're going to talk about how to leverage social media paid ads in 2020 and beyond. A hot topic, everyone's wondering what is going to happen with paid and the algorithms and all that great stuff. So Phil Graham, he's a wonderful friend of mine who's become a friend after us working together since I launched our agency. And the reason why I really reached out to him and started to get to know him in his work is because he is very, very experienced deep in Facebook ads, Instagram ads, and YouTube ads amongst other digital competencies. And so Phil, why don't you say hello? Phil Graham:                   Hello. I am so excited to be here and thank you so much for the kind introduction, and I'm really excited to talk about this stuff because being able to run ads the right way can literally make the difference between success or failure for an entrepreneur or a business, especially moving forward. So I'm excited. Carey Sperry:                   Yes, thank you. And he's been on a several other really great podcasts. So we found this as a wonderful way to connect with our audience and share information that we're always talking about with our clients. So to kind of kick us off, what would you say is the fundamental differences between Facebook and Instagram ads? It's a question we get a lot, like which should I advertise on Facebook or Instagram and what are the fundamental differences between them? Phil Graham:                   Yeah, great question. And you definitely should ... most people should be on both but they do have differences that are pretty different. So for Facebook, the age is the big differentiators. So if you want to reach somebody that is ... and I don't like talking about age too much because there's always variables, but in general like 35 or 40 plus, you're more likely to reach them on Facebook and under 35 maybe even under 40 the numbers creeping up, you're more likely to reach them on Instagram. In this day and age, the default for somebody who's like a celebrity or somebody who's in media is going to be like Instagram or Twitter, not necessarily Facebook. So they're both great places to be. But depending on like the target, the age of your market, you want to definitely be both places but put more money, time and effort into the place where your target is spending the most time. Phil Graham:                   Just like if you want to reach 17 year olds, if you had a product for that, you wouldn't be on Facebook, you'd probably be on TikTok and some other places that are coming up. So it's audience is the biggest difference, and then also intent. On Instagram, short, punchy videos and lots of great images work well. And on Facebook, a little bit still shorter videos but not as short. You can go longer on the videos and do some different, and those are like the main differences. Carey Sperry:                   So I hear some people say, "Well, why would I advertise on Facebook when people go on there to connect with their friends and family?" Phil Graham:                   Yeah, and that's a, that's a great question. That is the perfect question because people are not on there to look at ads, are they? They're not using Facebook for that, they are using it for many other reasons and we're interrupting them while they do that. But the reason what you want to do that is because billions of people use it and it's the perfect place to actually get their awareness and get their attention. So I think of Facebook, like a social gathering, a social dinner party, something like that where there's people doing social things. And when you think of it that way, think of going to a dinner party. If you were to go to a dinner party tonight and you walked up to a stranger, you wouldn't just walk up and immediately pitch your product. If you wanted to try and sell your product tonight, you wouldn't just do that. Phil Graham:                   You would start off having a conversation and then maybe in a future conversation it would be the right time to tell them about what you do and how you can help them. But on Facebook, what most people do is they send out these ads that are literally just pitching their product, Hey, give me your email and I'll show you this. Or buy this, buy that. And they're sending these to cold traffic to strangers, not realizing that even though it's on the computer, it's no different than if you were in person. There's a human being on the other end of that. So if you do it that way, you're probably going to fail. But my version of in real life, if you wanted to talk to a stranger and become friends and then eventually let's say maybe sell them something or help them, let's say help them. Phil Graham:                   It's not just about selling them, you would just go up and start a conversation. And so my version of starting a conversation using Facebook ads is to put out valuable content as an ad. What most people do is they try and put out some value organically, but when it's time to run ads, they just do these spammy sales pitch ads. And I'm saying, "Don't do that." Do the great stuff, the educational stuff, the inspirational stuff as an ad. That's like having a conversation. And when you start doing that instead of just immediately trying to sell somebody, your whole world can change. And it's really exciting. It can work extremely well. We've had clients, it's not the norm, but we've had clients go from zero to a million dollars in sales in just six months. Again, that's not normal. It doesn't happen a lot. But the fact that it did, it's possible when you do it right. And that's exciting to me. Carey Sperry:                   Wow. Yeah, I would love that. Phil Graham:                   Who wouldn't, right? It's so amazing that, that it's possible and when you really connect with people and then follow up in a smart way, it's just like if you, let's say you were out and about and you moved to a city and you had no friends at all. You didn't know anybody, and you wanted to start making friends. Well, you have to start talking to people to enable that to happen. And if you, let's say you start talking to somebody, you just strike up a conversation like at Starbucks or something, that person is not going to be your best friend right away. Phil Graham:                   You literally just met them. Do you need more conversations. You need more frequency of conversations with them before you start to really get to know each other. And many times when you're running ads, you need the exact same thing. Now, if you've got like a $20 e-commerce product, that's a little bit different. But for most people, if they're selling a product or service that isn't a cheap impulse buy, you need frequency. You need to start conversations by giving value before trying to sell anybody. And when you do that, you stand out because guess what, nobody else does that. And 99% of the ads you see are probably spam sales pitch ads that people hate. And so when you do it right, you stand out. And that's the exciting part. Carey Sperry:                   Yes. It kind of reminds me of us being the first generation of having digital kids and we tell our kids, "Don't type something on a text," or through through whatever means you're on. It might be on a social media platform that you wouldn't say to someone's face and it's a little bit different, but it's sort of the same thing. Like don't assume just because you're going through an ad and you're not actually looking at the person and interacting with them in real life that they're going to take your content in a different way than they would face to face. I've heard you use the analogy before where like if you're at a party, you don't just walk up to a woman and say, "Hey, let's get married." You got to warm up to them. And so yeah. Phil Graham:                   Yeah. And a lot of people will run ads like that. They'll like metaphorically speaking, they run ads, I call it like they profit shoot themselves in their ads. I know it sounds kind of weird, but like they're really, immediately going for a sale or an email address. Even though the person doesn't know who they are, they gave no value or credibility first and they're just doing that over and over. And then when it doesn't work, they blame Facebook or Instagram or YouTube ads and say it doesn't work, which is not the case. So when you do it right, great things can happen. There's no easy buttons. It doesn't just magically happen for you. You've got to do it right and you've got to work hard at it. But when you do, it's awesome because nobody else does it. Carey Sperry:                   Doesn't the algorithms, depending on what platform the ads are being run on, take some time for some sets of ads where it's smart to not expect the best to happen within the first month or even second month, that really to get rolling. Sometimes it takes a little longer. Can you talk a little bit about that? Phil Graham:                   Yeah, absolutely. That's a great point. Sometimes you can get immediate results, but a lot of times it takes time and testing and there's so many factors too. Like how much is your budget, how big is your audience? And things like that. There's plenty of times where it might take a couple months to really kick in, especially if you have a larger audience or a smaller budget that's completely normal and you have to be able to give it the time. I love using analogies and there's many times somebody will start some ads and a week or two later they might freak out if they're not already making all kinds of money. And my analogy for that is like if you were in a football game, you ran two plays and you're freaking out because you're not ahead 20 to nothing yet and you've only ran two plays and you're ready to just quit the game. Phil Graham:                   And I'm like, "Wait a minute, you only ran two plays. We have a huge game left." A lot of people just run two plays and stop, meaning they run ads for a week or a month or whatever, and then if it doesn't work right away, they think it didn't work and they quit, and that's a recipe for disaster. You also have to look at intent. How are people using Facebook? They're using it many times when they're multitasking, they might be standing in line at a grocery store, or Target, or something, or they might be at a stop light, or cooking dinner, or doing two or three things at once and they may see your ad and they may actually love what they saw, but the timing might not be right for them to actually buy something at that moment. And many times it's not right at that time and/or they may not trust you yet. Phil Graham:                   They may not know who you are. They may need to see a little bit more from you first. And so when you take that into account and you don't just try and sell somebody on the first ad, but there's an actual formula here. You're not just going to send them an ad, you're going to send followup ads to people that actually watched your initial ads and you're going to keep giving them value. When you start doing that and you give it the time to work that it needs, then it becomes a beautiful thing that can work extremely well for people. Carey Sperry:                   Yes. So what is working with Facebook ads for you? Phil Graham:                   First of all, first and foremost, having a system that you can use that attracts your ideal customers or clients, whatever you call them, that attracts them, gets their awareness, attracts them to you and brings them in and then converts them into a paying customer or client. So that you don't have to number one, chase after business, and number two, since you're attracting them to you, it's more valuable and you can charge what you're worth. Having an overall system is the key. You don't want to just run a few ads. Phil Graham:                   Number two, doing value based ads. I actually have a formula I use that I call EED and it stands for educate, entertain, and differentiate. So when you're creating your ads, especially if you're doing like a video ad, you want to try and do all three in your video, you want to educate your audience and that can be through teaching them something, or it could be by inspiring them or giving them hope, or both. So that's educate. Phil Graham:                   Entertain means you just don't want to be boring. It doesn't mean you have to be like this super charismatic person or anything like that. You just have to have passion about what you're talking about. Or maybe if you're doing a video, you're doing it in a location that looks nice or you're using a prop. You're grabbing your phone to get their attention, something like that. Phil Graham:                   And then differentiate. You need to be different than all the other advertisers out there that are inundating your ideal audience with ads. And if you can do those three things in your content, you can do extremely well and you wrap those into, I like 30 to 60 second video ads. I think in this day and age, and in 2020, video ads are the most undervalued, best way to build your brand, make money and grow your business, by far. But it's not going to last forever. I remember when you could get like Google ad words, you could get keywords like mortgage based keywords for like five cents a click and the those same key words now, instead of five cents or click are anywhere from fifty to a hundred dollars a click. Carey Sperry:                   Wow. Phil Graham:                   So here's the crazy thing. I mean that's insane, right? I mean people would do anything to get five cents a click- Carey Sperry:                   Absolutely. Phil Graham:                   ... just about, in this day and age. But I believe that video ads on Facebook, Instagram, and YouTube are still in that, that wild West price where it's super cheap and I believe that over the next couple of years where you might, we might be getting one, two, three, ten cents per targeted view right now, that probably going to go up 10x or even more. But you've got a sweet spot of time right now where you can leverage and take advantage of that before it's too late. Phil Graham:                   As more and more big companies pour money into it over the next few years, it's going to go up just like Google ads went up, but right now you have the ability to leverage undervalued attention on Facebook, Instagram, and YouTube, especially video ads. And then when you do it the right way, like I've been talking about, you stand out, you can attract people to you, you'll have a system that you can scale and rely on that's not built on hope or chance, which is what most people do and that's the true win. That's the way to like Bulletproof yourself for the future and protect yourself. Carey Sperry:                   Right, and the system is a proven system that has experience behind it, whereas it's not magical where it's just pulled out of a hat, and then a couple of weeks an ads out there that seems to be good and then it doesn't work after two weeks and then, "Okay, I got to stop." Like you gave the football analogy with two plays, it takes a system and it takes also some time at times, and retargeting. Phil Graham:                   Absolutely. And retargeting, yeah. I mean, we've been working on this for many years and everything we do is actually based off of data, not guessing. So when we run ad campaigns, we look at the data, we see what works and what doesn't, and then we make adjustments. And what most people do is they just kind of go off of, "Oh I've, I think this will work." Or, "Hopefully this will work," and they don't really know how to look at the data or they don't want to. We look at the data and then we make decisions based on that data and create this framework that I've been talking about based on that. And so that gives you a great model for success when you do it that way versus most people are just not doing it at any kind of a level like that. Carey Sperry:                   So what kind of trends are you seeing currently? Can you talk a little bit about what they are and what trends you're seeing? Phil Graham:                   Yeah, great question. So a lot of trends I see are things that are not good, and that if you do these things, it's going to hurt you. So you want to make sure you avoid these things. Trend number one I would say is focusing on vanity metrics. Likes, comments, shares. There's so many people that that's the indicator of success when they see it, like if they put out content, if they get enough likes, they feel like it's successful. If they don't, then they don't. They feel like it's not successful, and that is not the measure of success. It doesn't mean put out content, it doesn't mean that at all. But what you should do is focus on something more than that and focus on helping transform your audience with great content and turn that into a sale. There's too many people ... Phil Graham:                   I'll give you a great example. The other day, actually, it was not the other day, it was about a month ago. I saw a couple of videos on YouTube. One video was from somebody who, they're going to remain nameless, but I know who they are and they make no money and they actually live in somebody's basement making no money. And they put out this video on how you can get, I can't remember the exact number, but a hundred or a thousand more followers on Instagram, and it actually had like 40,000 views. Now, same day, another video got put out by the CEO of Zoom, which is a conferencing software. He's a billionaire. He started with zero, built himself into a billionaire that had like maybe a hundred views. So that's the problem. People are like chasing after, "Ooh, how do I get 100,000 more Instagram followers?" And they're not actually focused on, here's a billionaire who started from zero, who's actually successful. Phil Graham:                   And he, he doesn't spend much time posting. But when he does, he hardly anybody was looking at it. So everybody's priorities are all messed up. I know people that make $150 million a year that if they post, I mean hardly anybody sees it and they don't care. It doesn't mean don't post. It's still important. As you know by the way, you guys Carey is phenomenal at organic social media and it's very important. So don't get me wrong that has a very important place in the success of a business. But what I'm saying is, if your primary way to get a customer is predicated on vanity metrics, you're setting yourself up for failure. You need to do a different, so that's one trend I see. Phil Graham:                   Number two, there's just too many people that use what I call templated ad. They'll find ads or templates from landing page services and they'll think, "Well, if this person did it, I'm just going to do the same kind of ad with the same kind of wording and it'll work." Well, guess what? I got news for you. That is a recipe for disaster, also. Phil Graham:                   I could tweet or do an ad or say the exact same things as somebody like Oprah, or Kanye West, or just insert any famous person's name here. I could say or do the exact same things, but am I going to get the same reaction or same results? Of course not. They're famous, right? They have this brand that literally they're ultra famous. So when you try and take a template that somebody else has done, even if it's working for somebody else, they actually have a brand behind it. There's a lot more to the success success than whatever they've just put in the ad. Phil Graham:                   And so too many people think that's all they need. I'm just going to copy company A or entrepreneur B and I'll get the same results. And it doesn't work that way. And I'm not saying don't look at what people are doing and try and get best practices, and I'm not even saying don't use templates, but what I am saying is mold them to your brand, your audience in your message. Don't just blindly copy and think you're going to succeed. Because I see people doing that all the time and it pretty much almost never works. Phil Graham:                   So those are some of the trends I see the most right now. And then also just people relying too much on hope and chance to get business. Versus if you focus on doing the right things, including paying for ads to guarantee your message gets put in front of people, then you're going to put yourself ahead of 99.9% of everyone else out there. Carey Sperry:                   Great points. I see that with the branding that people, businesses know who they are and who their customer is and how they're different, but they don't always take the time or at least circle back to it as time goes on. Because they're so busy and they're focused on so many different things, and they assume that their customers know their brand and they don't hone in on specific words and tones and things like that around their brand. And so of course when they go to try to make an ad, they're not thinking of letting that shine through. And the second thing is a lot of people just don't want to do the work with ... Yeah, it's just a lot. Phil Graham:                   That's a good one, right? Carey Sperry:                   It's a lot to learn. It's a lot. Looking at the data they might not enjoy it like you do. And so those are, those are some really important things to think about and it works. And so it's super exciting and our time has already zipped by. I knew it would go so fast. Phil Graham:                   This has been fun though, right? Yeah, it went by fast. Oh my goodness. Carey Sperry:                   It did, but what we can do is maybe talk again in a few months or something and circle back- Phil Graham:                   Yeah, for sure. Carey Sperry:                   ... and it'll be maybe 2020 by then and we can address some of the new things that are surfacing. I know you have an assessment that people can use with some of these. It allows them to kind of think through their specific what they want to sell and maybe what they want to think about through ads. Is there, is there anywhere they can find that or maybe you and I can create that and put that in the show notes and allow people to- Phil Graham:                   Yes we can definitely, sure. We can put that in the show notes. And you and I have worked together on some stuff. So I like, by the way, again I want to say this a lot, you are amazingly good at what you do. So everybody listened to this, you're in the right place. Carey Sperry:                   Thank you, Phil. Phil Graham:                   Carey knows her stuff, and it's been awesome working with you on some projects, by the way. And so I wanted to make sure and say that. If anybody wants ... so the show notes will be great. We can put some stuff in there. And then my website is philgrahamdigital.com if you ever want to get in touch. The other thing, too I want to mention is I do have a podcast on Facebook ads that I've been doing for over two and a half years. I do a weekly episode every single week and that has a lot of value. Phil Graham:                   It's just pure content every week. So it's called the Next Level Facebook Ads Podcast. You can either search for that on Google or maybe we'll put it in the show notes and it's also on my website. So if you want more Facebook ads specific stuff, there's a lot of stuff in there and there's new stuff every single week. But lastly, I do want to mention, we talked about Facebook and Instagram a lot in here. I'm also very big on YouTube ads and even Google ads as well. So I don't want to ... A big mistake is only doing Facebook stuff. You definitely want to be other places, with ads especially, as well. So make sure you guys are kind of diversifying your ad spend, and being real smart about it. Carey Sperry:                   Yes, yes. We can do another episode on YouTube ads alone. Phil Graham:                   Oh yeah, absolutely. We do a whole episode just on that because there's some really cool things that are different about YouTube ads, so that would be fun. Carey Sperry:                   Fun. Okay everybody check out Phil's podcast and website, and thank you so much. It's been wonderful talk with you as always and if you liked this episode, please give us a follow, a subscribe, and a review, and thank you so much and we'll see you next time. Phil Graham:                   Thanks everybody. Carey Sperry:                   Thanks for listening to the All Social Y'all Podcast. For free resources and materials, head over to allsocialyall.com. That's All Social Y-A-L-L dot com. Also, we'd love to hear from you, what subject areas would you like to hear about in future episodes? You can share that with us by dropping me a comment on our website or in Instagram at All Social Y'all.  

本周，《死亡搁浅》《如龙7》《抵抗计划》与《健身环大冒险》均公布了大量信息，展示了游戏的具体玩法。参与人：雷电、赞恩OP：Looks That Kill - M?tley CrüeED：渋谷川 - 欅坂46

本周，《死亡搁浅》《如龙7》《抵抗计划》与《健身环大冒险》均公布了大量信息，展示了游戏的具体玩法。参与人：雷电、赞恩OP：Looks That Kill - M?tley CrüeED：渋谷川 - 欅坂46

“Life is too short. You only have today. Don’t waste another moment of your precious life living with negative thinking.” Diane Forster (20:45-20:53) When you stop negative thinking, you can manifest abundance in every area of your life.  For over two decades, I lived such an unfulfilling life that I attempted suicide. But in that bathroom, I had a God moment. The pills were knocked out of my hands and a voice screamed in my ear, “You’re not going to end your life this way. You need to get help so you can tell your story and help others.” I reached out for help and started developing processes to help me live intentionally and positively every single day.  “What I was manifesting in my life previously was a direct result of not just the thoughts but the words, too.”  -Diane Forster (5:22-5:29) This was when I discovered the power of mantra meditations, and my massive transition into an abundant life came to be. I want to help you make this massive transformation, too. There are two main myths surrounding negative thoughts.  Myth #1: There’s something wrong with me. I’m here to tell you, there is nothing wrong with you. The negative thoughts are what you’ve taken in from other resources, other people, and the environment. And it happens to EVERYONE.  Myth #2: This is the way I’ve always been, so this is the way I’m always going to be. This is simply a limiting belief. I promise, you don’t have to stay stuck with these thoughts for ever.  You have the power to change that belief, and break through the walls standing in the way of an abundant life.  Keys to Turn Around Negative Thinking Key #1: Create awareness. Learn to be aware of the very moment your thoughts, words, feelings, and actions start moving in a negative direction and then ask yourself, “Is that really true?” I talk about this process in my book, I HAVE TODAY: Find Your Passion, Purpose and Smile...Finally! on page 61, which I call the EED process -- Emotional Energy Diffusers. This is a three-step process: Breathe Think - Is this really true? Praise - Commend yourself for catching the thought in that moment.  Key #2: Change Your Beliefs Beliefs are just thoughts you’ve been thinking over and over again. The beautiful thing is, you can change your beliefs.  What do you desire to be true about yourself, your relationships, your life? It’s time to start speaking about yourself the way you WANT to see yourself. You are smart. You are beautiful. You are capable of maintaining lasting, fulfilling relationships, if that is what you desire.  Key #3: Build Momentum You build momentum by starting a new routine. Just like you feed your body every day with food and water, you feed your subconscious mind every day with positive, uplifting thoughts. Incorporate positive thinking into your DAILY routine. Get into the habit of feeding your mind the thoughts of abundance. As soon as you desire something, the Universe is already at work, putting the actions into motion to bring you what you desire. Consistency is the key to replace the negative thought patterns that have been ingrained into your mind for years.  “Get ahead of it, create the awareness, change those beliefs, build the positive momentum, and start living in the abundance that you came here to live. You don’t have a moment to waste.”  -Diane Forster (20:54-21:07) I’ve just barely scratched the surface about changing negative thoughts. If you’d like to explore this concept more deeply, you can:   Check out my book on Amazon: I HAVE TODAY: Find Your Passion, Purpose and Smile...Finally!  Sign up for my Rapid Mindset Shift -  a powerful personalized mantra I custom created just for you. When you listen to your personalized mantra meditation every day, it creates awareness of negative thinking, changes that belief, and builds momentum. You will see your life shift within 30 days or less.    It’s time to shift your thinking. Take your mind back, take your life back, and find your passion, your purpose and your smile. Invest in yourself. I know you’re worth it, even if you aren’t quite sure about that… yet.  How to get involved For more information about working with Diane and to gain access to valuable resources visit dianeforster.com.  You can contact Diane for coaching information at info@dianeforster.com. To learn more about the EED Process discussed on today’s episode get Diane’s book, I Have Today: Find Your Passion, Purpose, and Smile… Finally.   If you liked this episode, be sure to subscribe and leave a quick review on iTunes. It would mean the world to hear your feedback and we’d love for you to help us spread the word!

In der heutigen Folge möchte ich mit dir über den Emotional Experience Day sprechen, indem wir zurück auf den letzten blicken. Denn ich möchte mit dir teilen, was eine Emotional Experience ist, was wir beim EED machen und was das ganze für mich eigentlich bedeutet. Ich bin unendlich dankbar für deine Unterstützung! Ich wünsche dir viele tolle Erkenntnisse bei der heutigen Folge! :-) __________ HIER kommst du zum Online-Kurs: https://yvonneschoenau.com/dankeseite-onlinekurs/?utm_source=ActiveCampaign&utm_medium=email&utm_content=Raus+aus+deinem+Kopf+-+rein+ins+Emotional+Leadership&utm_campaign=NL+Juli+Tino Was hat es dich bisher gekostet, so zu sein, wie andere es wollen? Es wird Zeit JA zu dir zu sagen. Für dich, deine Wünsche und deine Sicht der Welt einzustehen, auf dem Emotional Experience Day. Mit dem Code „rausausdeinemkopf“ bekommst du 25% Rabatt: Sichere dir jetzt dein Ticket: https://www.eventbrite.de/e/emotional-experience-day-by-yvonne-schonau-tickets-63509947964 Finde heraus, welches Emotionale Schutzprogramm du besitzt und wie dich dieses blockiert. Mache jetzt den Test: https://yvonneschoenau.com/kaktus/ Hier kommst du zum KOSTENLOSEN Ebook: https://yvonneschoenau.com/#download __________ Lass uns gemeinsam diese Welt verändern: Facebook: https://www.facebook.com/YvonneSchoenau.Training/ Instagram: https://www.instagram.com/yvonneschoenau/ LinkedIn: https://www.linkedin.com/in/yvonne-sch%C3%B6nau-2a581665/?originalSubdomain=de YouTube: https://www.youtube.com/channel/UC3g67dN26I14IzHodhKVKoQ

This month on the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from recent issues of Circulation Research and talks with Steve Lim and James M. Murphy about their article on nuclear FAK regulation of smooth muscle cell proliferation. Article highlights: Li et al: Histone Turnover in Adult Heart Kurosawa et al: Celastramycin Ameliorates Pulmonary Hypertension Urban et al: NOS3 Gene Polymorphism and Coronary Heart Disease   Transcript Cindy S.:                               Hi, welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal, Circulation Research. I'm your host Cindy St. Hilaire, and I'm an assistant professor of medicine and bioengineering at the University of Pittsburgh. My goal as host of this podcast is to share with you highlights from recent articles published in the July 5th and July 19th issues of the Circulation Research Journal. We'll also have an in-depth conversation with Drs. Steve Limb and James Murphy, from the University of South Alabama College of Medicine, who are the lead authors in one of the exciting discoveries presented in the July 5th issue. Cindy S.:                               The first article I want to share with you is titled, Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in the Adult Heart. The co-first authors are Yumei Li, Shanshan Ai, Xianhong Yu, and the corresponding author is Aibin He. This research was conducted at the Institute of Molecular Medicine Beijing Key Laboratory of Cardiometabolic Molecular Medicine and the Peking-Tsinghua Center for Life Sciences. Both of which are part of the Peking University in Beijing, China. Cindy S.:                               In the nucleus of cells, DNA is packaged into a structure called chromatin. Chromatin can reside in an open state that is permissive to gene transcription, or closed state where transcription is inhibited. The core units of chromatin are called nucleosomes. A nucleosome consists of DNA that is wrapped around proteins called histones. It's the position of these nucleosomes that determines whether the chromatin allows for DNA transcription or not. There is a large body of research that is focused on understanding the epigenetic processes that promote or repress transcription. Most of this research focuses on the processes that read, write, and erase covalent histone modifications. But, histones are proteins, and proteins, as we all know, have finite half-lives. Cindy S.:                               Far less research has been conducted to understand the dynamics of histone assembly and disassembly on specific regions of DNA. In this study, the authors took a novel approach of using a GFP-tagged histone H2B protein to track in vivo the rate at which nucleosomes are replaced in cardiac chromatin, and to what extent this rate varies across the genome of those cells. This is particularly interesting, and a particularly good cell type to study, as cardiomyocytes rarely divide or proliferate in the adult heart. What they found was intriguing. Nucleosome recycling is not even across the epigenome of cardiac cells. Instead, gene promoters, enhancer, and other regulatory regions that are known to promote gene transcription all exhibited a higher histone turnover rate than regions of the epigenome that are not occupied by these permissive remarks. Cindy S.:                               Further, they found greater histone turnover at loci for cardiac specific transcription factors as compared to loci for pluripotency transcription factors. This implies preferential access to these regions. Digging further into the mechanism, they discovered that the repressive chromatin regulator, EED, promoted this histone turnover. The epigenetic signature is what helps to define the identity and function of a fully differentiated cell. This study suggests that loss of histone turnover may promote loss of the proper epigenetic signature of a fully differentiated cell. These exciting findings suggest replication independent histone turnover is a requirement in maintaining both epigenetic and functional homeostasis in the adult heart. From this, one may hypothesize that perhaps aberrations in histone turnover contribute to age related diseases in the cardiac tissue, as well as possibly other tissues. Cindy S.:                               The next article I'd like to highlight is titled, Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds. The first author is Ryo Kurosawa, and the corresponding author is Hiroaki Shimokawa, both from the department of cardiovascular medicine at Tohoku University Graduate School of Medicine in Sendai, Japan. This article is focusing on the disease pulmonary arterial hypertension. Cindy S.:                               Pulmonary arterial hypertension, or PAH, is a disease that stems from the increased proliferation of arterial smooth muscle cells in the lungs. This proliferation leads to a progressive occlusion of the pulmonary arteries. This occlusion also causes increased pressure in the right heart ventricle. That can lead to heart failure, and ultimately death. Basal dilatory drugs are currently used as therapy in PAH, as they help to open the blood vessels, which can alleviate some of the symptoms. However, these drugs do not target the underlying cause of the symptoms, which is the hyperproliferation of the smooth muscle cell. Cindy S.:                               To identify novel compounds that inhibit smooth muscle cell proliferation, Kurosawa and colleagues used a high-throughput approach. They isolated cells from patients with pulmonary arterial hypertension and used these cells in a high-throughput approach to test 5,562 novel molecules on their ability to inhibit the proliferation of these cells. This unbiased approach yielded several potential compounds that potentially reduced smooth muscle cell proliferation from these patients, and also had very minimal deleterious effects on healthy control smooth muscle cells. From there, the team tinkered with the structure of the drug Celastramycin to try to increase its efficacy, and with that tinkering they found in vitro, that their new molecule could reduce both the inflammatory signal that helps to drive the proliferation of the smooth muscle cells, as well as reactive oxygen species, which helps to drive the inflammatory signaling. Cindy S.:                               Moving forward to in vivo studies, the team found that their new treatment also reduced right ventricle systolic pressure and hypertrophy in three different rodent models of pulmonary arterial hypertension. This treatment improved exercise capacity in one of the models. Together, these exciting results indicate that Celastramycin could be developed as a potential therapy for pulmonary arterial hypertension. Cindy S.:                               The last paper we're going to talk about before switching to our interview with Drs. Steve Limb and James Murphy, is a paper titled, 15-Deoxy-Δ12,14-Prostaglandin J2 Reinforces the Anti-Inflammatory Capacity of Endothelial Cells With a Genetically Determined Nitric Oxide Deficit. The co-first authors are Ivelina Urban, Martin Turinsky, Sviatlana Gehrmann, and the corresponding author is Marcus Hecker, all from the department of cardiovascular physiology at Heidelberg University in Heidelberg, Germany. Cindy S.:                               Nitric oxide is a vasodilatory and anti-inflammatory molecule, and thus, beneficial to cardiovascular health. Homozygosity of a single nucleotide polymorphism, or SNP, is a gene nitric oxide synthase results in reduced ability of endothelial cells to produce nitric oxide, specifically in response to fluid share stress. Decreased bioavailability of nitric oxide in the vessel wall helps to promote atherosclerosis. The SNP that we're referring to in this paper is called T-786C, where TT homozygosity is considered the control, or healthy genotype, and CC homozygosity is the disease associated. CC homozygosity of this SNP is predictive of atherosclerotic related diseases, and consequently, individuals with CC homozygosity have an increased risk for coronary heart disease. Cindy S.:                               Now, despite this detrimental evidence, homozygous patients do not develop atherosclerosis at an accelerated rate. This suggests that there's a compensatory mechanism at play. To identify how CC homozygous cells compensate for reduced nitric oxide synthase activity, the authors utilized human umbilical vein endothelial cells, that are also called huvecs, that harbored either the TT or the CC version of this SNP. They also used these in combination with a monocytic cell line. Cindy S.:                               Urban and colleagues found that under fluid share stress conditions, human endothelial cells homozygous with for the CC variant, had increased production of an anti-inflammatory prostaglandin called 15d-PGJ2. Signaling, via this prostaglandin, helps to compensate in part for the reduced endo production. This prostaglandin suppressed monocyte activation by reducing expression of pro-inflammatory genes such as aisle 1 beta, and decreased monocyte transmigration through endothelial cells. The team also found that patients with coronary heart disease were more likely to have the CC homozygous variant than age match controls. Thus, not only did they identify a partial compensatory mechanism, the authors suggest that 15d-PGJ2 could be a useful biomarker for the diagnosis of coronary heart disease. Cindy S.:                               So that's it for the highlights of the July issues of Circulation Research. Thank you very much to Ruth Williams, who writes the In This Issue copy for the journal, as well as the editorial team at the journal and at the podcast. Cindy S.:                               Okay, so now we're going to talk to our team of first author and last author. Today's paper that we're talking about is Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription. The first authors of this papers are Kyuho Jeong, Jung-Hyun Kim, and James M. Murphy, and the corresponding author is Steve Lim. Today, we're going to be speaking with James and Steve about this paper. So thank you, both of you, for joining us today. Steve Lim:                           Thanks for having us today. Cindy S.:                               Great. Congratulations on your beautiful paper. I was wondering if maybe we could just start by both of you introducing yourselves, telling us your current position, and maybe about how you came into this field. Steve Lim:                           Hi, Cindy. We appreciate the opportunity to discuss our paper. I'm Steve Lim, an associate professor in the department of biochemistry and molecular biology and medicine at the University of South Alabama. I received my PhD from University of Alabama at Birmingham. I did my post-doctoral training studying the law of FAK in cancer biology at UC San Diego Moores Cancer Center. In 2012 I started my own lab here at South Alabama, where I decided to focus on vascular biology using some pharmacy data I generated at the end of my post-doctoral study. James Murphy:                 I'm James Murphy, I'm a post-doctoral fellow in Dr. Lim's lab at the University of South Alabama. My path to science was a little different than most. I got an undergraduate and graduate degree in mathematics before I joined the PhD program here at South Alabama. Due to a family history of cardiovascular related deaths, I decided to join Dr. Lim's lab due to his interest in studying vascular disease to find new therapeutic targets. Cindy S.:                               Interesting, a math major. James Murphy:                 Yeah. Cindy S.:                               Has that been able to help with any of your basic science studies? James Murphy:                 I'm pretty good at doing concentrations. Cindy S.:                               You're the expert in lab math. James Murphy:                 Yeah. I think the logic skills and critical thinking skills that I picked up in math really help out here in science. Cindy S.:                               Oh, I bet, that's wonderful. You're the dream PhD student who can hit the ground running with M1V1 equals M2V2. Great. Well, thank you so much. I really liked this paper because I love the mechanosensing and how does a cell read what's outside, and how does that message get brought to the inside. Really, that's what you're finding in this paper, specifically looking at how FAK is mediating transcriptional regulation. Maybe you can start by just telling us, what was your overarching question when you started this study? Steve Lim:                           Sure. It is very well-known fact that promotes cell proliferation and migration through interior receptors and gross factor receptor signaling. Both of which are key components in the smooth muscle cell hyperplasia. So naturally, we asked ourselves a simple question, "Is FAK activity important for smooth muscle cell proliferation, and leading into hyperplasia?" Cindy S.:                               So when you say FAK activity I think one thing that's interesting in your paper is, FAK really has kind of two different functions, and one is the kinase function. A kinase is when it can phosphorylate another protein, so it itself is an enzyme. But, then it has another function, so can you maybe tell us about those different functions of FAK? Steve Lim:                           Right. So FAK can function as a kinase, as well as a kind of independent scaffold, which can recruit different proteins. In the paper, we specifically described a kinase independent function as a nuclear function, nuclear FAK function. Cindy S.:                               Interesting. So what premise, or what gaps and knowledge were present before your study, that you were trying to address? Steve Lim:                           Actually, a study showed that the knocking off FAK in the smooth muscle cells prevented neointimal hyperplasia. As just you asked question, FAK has two different functions. Since FAK has both kind of dependent and independent [inaudible 00:14:48], this study lets the unanswered question, which of these two different functions of FAK plays a larger role in dealing with hyperplasia. We aimed to inhibit FAK activity to distinguish between FAK kind of dependent and independent roles in dealing with hyperplasia. Cindy S.:                               Interesting. How exactly were you able to do that? How could you take and dissect apart the two different functions of this protein? Steve Lim:                           We started off with a small pile of experiment to test if a small molecule FAK inhibitor could block neointimal hyperplasia, and we were very surprised at the degree to FAK inhibition actually prevented neointimal hyperplasia following vascular injury. Cindy S.:                               Yeah, and that's in figure one. I was looking at that, it's quite striking. Steve Lim:                           Actually, to distinguish these two different functions we generated new genetic FAK–Kinase-Dead mouse model in conjunction with a FAK inhibitor model, and that would allow us to study a lot of FAK activity in smooth muscle cells. Cindy S.:                               Great. James, could you tell us about the mouse model that you developed for this study, and the specific mutations that you created and what you were allowed to test with those models. James Murphy:                 So the FAK–Kinase-Dead knock-in model was actually generated during Dr. Lim's post-doctoral studies. Cindy S.:                               Is that the exciting data? James Murphy:                 The mutation is just a simple lysine to arginine mutation of amino acid 454. What they found was that, actually, homozygous kinase-dead embryos was lethal. So you need FAK activity to actually develop a full grown organism. We kind of had to cross a hetero wild-type kinase-dead mouse with a phlox FAK mouse, which eventually, if you cross with tissue-specific Cres, what you end up with is a phlox wild-type or a phlox kinase-dead mouse. Then, when you treat Tamoxifen in your Cre mouse, then you delete one copy of wild-type FAK and you're left with either a single copy of wild-type FAK, or a single copy of kinase-dead FAK. Cindy S.:                               Very nice. So for your study, you used, if I recall correctly, the myosin-11, Tamoxifen-inducible Cre model. Can you maybe talk about why you chose that model and why not the SM22 Cre or a non-inducible model? What was your strategy? James Murphy:                 As I mentioned, FAK activity is important for embryo genesis, so we thought we had to use an inducible model, so as to make sure we had an adult mouse at the time of the experiment. We originally actually had the SMA Cre model, however, some grant reviewers had told us that we should kind of shift to the more myosin-11 mouse to be more specific to the vascular. One downside to that, as we mentioned in the paper, is that that's actually only on the Y chromosome, so you can only use male mice. Cindy S.:                               Yes. But, at least it's in only the smooth muscle cells. Is that kind of the pros and cons of that model? James Murphy:                 Yes, and the MYH-11 Cre is kind of the most accepted model when you're doing smooth muscle studies. Cindy S.:                               Great. So can both of you go over some of the key findings of your paper? If we're going to say this in a tweet, what would we say? James Murphy:                 In a tweet. So I think, as we talked about, FAK can go to the nucleus. It's kind of constantly shuttling between the nucleus and the cytoplasm, at least what we've been able to observe in vitro. However, kind of a its localization in vivo still kind of was up in the air at the time. However, our immunostaining data actually rebuild that healthy uninjured arteries primarily showed FAK was in the nucleus. Suggesting that FAK was inactive, and maybe somehow suppressing smooth muscle cell proliferation by staying in the nucleus. But, after wire injury, FAK not only increased its activation, but also shifted to be primarily within the cytoplasm, and eventually we showed that that increase of GABA4 protein stability leading to proliferation. Cindy S.:                               Very interesting. That's great. So what was the hardest part of this whole study? James Murphy:                 Dr. Lim did the preliminary FAK inhibitor studies, but he had people when he started his own lab, he had to teach us how to do the wire injury. At first, learning gets kind of technical, you have to get used to using the microscope. Cindy S.:                               Could you describe the wire injury model for us? James Murphy:                 Yes. What you do is you anesthetize the mouse and you actually locate the femoral artery, and you want to kind of reveal the muscular branch. What you do is you add suture proximal and distal to the muscular branch of the femoral artery to stop blood flow. Then, you're going to cut a small incision in the muscular branch, and you insert a small wire through the branch up into the femoral artery towards the iliac branch. What this does is denude the endothelial layer and kind of causes an extension of the artery, damaging the smooth muscle layer. Once you remove it and suture off the muscular branch, then after a couple weeks you start to see hyperplasia. Cindy S.:                               Interesting. So what does this model clinically? James Murphy:                 This model kind of mimics angioplasty procedures that one may have if they have an occluded artery. There's multiple angioplasty procedures. There's a physical dislodging and opening of the artery. Then, there's some other methods such as using a stent to keep it open. Cindy S.:                               Great. Very interesting. What do you think would happen in maybe, I don't know, an LDLR knockout that was crossed with your FAK kinase deficient mutant? What do you think would happen in an athero model? James Murphy:                 We're actually- Cindy S.:                               Or is that the next paper? We don't have to talk about it if it's the next paper. James Murphy:                 We're actually currently testing that right now. Cindy S.:                               Oh, okay. James Murphy:                 So that's kind of our next step is to test this in atherosclerotic models to see what happens. Cindy S.:                               So, what might this mean for potential therapeutic target? How could we leverage this data to possibly translate it to the clinical setting, even if it's far off? What might we want to do moving forward? Steve Lim:                           Speaking of translational potential, currently most of the treatment options for narrow vessels rely on thrombolytic stents, that provides local delivery of anti-proliferative drugs. However, DES comes with several disadvantages, including location, work, size of these affected vessels. In fact, inhibitors are under cancer clinical development, have never been used in the vascular diseases. Our study, I think, at least to show the potential for using this type of FAK inhibitors in treating hyperplasia, which was not possible before. Cindy S.:                               That's interesting. So essentially, there's already potential, therapy's already available that would just have to be tested in this new ... in this new vascular realm, essentially. Steve Lim:                           Yeah. I was thinking about effication of these type of drugs. I think it could be, as you said, PAH could be one of the targets, because they're not really useful drugs available now. In the future, what we actually, we started already, but it's known, these moments of proliferation plays key role in the arthrosclerosis progression. Studies targeting neointimal hyperplasia and atherosclerosis, it's not existing. I think in the future probably, we would like to test whether in fact inhibition and the smooth muscle cells reduce its atherosclerity in animal models, and hopefully in humans. Cindy S.:                               Yeah, yeah, hopefully in humans, always. Yeah, and in those mouse models, there's always interesting studies where you can block things from the beginning. But, I think one of the beautiful things about the mouse model that you created, the fact that it's Tamoxifen inducible, you could essentially let that atherosclerotic plaque build up for a bit and then knock it out and see if it can reverse it. So the model you created is a really wonderful tool to use for a whole bunch of studies. So congratulations. Steve Lim:                           Thank you. Cindy S.:                               Yeah, I thought the most interesting aspect of this paper was really the fact that it could link this FAK protein, this integrin signal mediating protein to the transcription factor GABA4. So could you possibly tell us a little bit about that interaction, and exactly what GAB is doing in the smooth muscle cell? Steve Lim:                           I actually think that the identifying GABA4 factor actually was one of the difficulties, because normal cells do not express GABA4, that's what is known. I think it's because, based on our finding, the smooth muscle cells in vivo, you could package more predominantly localized in vivo, the nuclear FAK is predominant. So that nuclear FAK finds GABA4 and reduces ability through the process on degradation. But, actually, not changing ... Nuclear factor is not changed. GABA4 mRNA are the expression, so GABA4 is always expressed in smooth muscle cells. But, we never see in healthy, or very freshly isolated smooth muscle cells. We never see Gaba4. That was the most difficult part actually. Cindy S.:                               So the mRNA is always there, it's just never making it to a protein that accumulates in any measurable quantity. Steve Lim:                           So you become a protein, but FAK, nuclear FAK kills all GABA4 in the nucleus. Cindy S.:                               That's the proteasome mediated degradation? Steve Lim:                           Right. Then, GABA4 actually promotes cycling D1 transcription. So no GABA4, no cycling the new one, and smooth muscle cells do not cycle. Cindy S.:                               Interesting. So can you maybe close the loop and tell us essentially what's in figure nine, like this. Could you talk us through that? Steve Lim:                           It summarizes in figure nine, I think it would be best, we can put two different situations. In healthy R3, FAK is in the nucleus, and GABA4 is reduced, cycling D1 is not expressed, and smooth muscle cells become high acid. They don't proliferate. But, in injured, actually, FAK localization is it's the vaso injury promotes FAK localization, vaso injury shifts FAK nuclear localization to cytoplasm. Actually, FAK is activated. Now, GABA4, that increases cycling T1 expression. So that causes intimal hyperplasia. That could be a kind of summary. Cindy S.:                               No, that's perfect. Congratulations on a very nice paper. I thoroughly enjoyed reading it, and I enjoyed even more speaking with the two of you. So thank you very much. Steve Lim:                           Well, thank you so much. Cindy S.:                               Thank you for listening. I'm your host Cindy St. Hilaire, and this is Discover CircRes, your source for the most up to date and exciting discoveries in basic cardiovascular research.  

Mme Gisèle Libawo, enseignante responsable de l'enfance en difficulté (EED), nous expliquera le fonctionnement de ce service, ces atouts et ainsi en finir avec les préjugés reçus par les parents d'élèves.

The US state Dept has imposed sanctions on EED, china’s equipment development dept responsible for procurement of arms. This after the body engaged in what Washington calls “significant transactions” with russia’s main weapons exporter Roso-boron-export. In protest at the move, Beijing summoned the US ambassador and cancelled joint military talks due in a few days. The Chinese defense ministry also says it reserves the right to take further countermeasures. china regards this as a blatant violation of basic norms of international relations and a manifestation of hegemony. why is the US concerned about china purchasing Russian fighter jets and S400surface to air missiles? stay with us and we will discuss the issue in today’s debate show. first, let’s watch a report. Watch Live: http://www.presstv.com/live.html YouTube: https://www.youtube.com/user/videosptv/ Twitter: http://twitter.com/PressTV LiveLeak: http://www.liveleak.com/c/PressTV Facebook: http://www.facebook.com/PRESSTV Google+: http://plus.google.com/+VideosPTV Instagram: http://instagram.com/presstvchannel

European Endowment for Democracy (EED) Executive Director Jerzy Pomianowski discusses how the EED came about and the focus of its work today. He shares his philosophy that democracy can only truly be generated from within society, not imposed from outside, which is the basis for EED’s demand-driven model of support. He also talks about the importance of flexibility when adjusting to a rapidly changing environment and discusses the EED’s rapid response projects that meet urgent demands for support.   Pomainowski also discusses the need for a new political philosophy to communicate the promise of democracy and solidarity, and how his past experience as a student activist in Poland shapes his drive to help those taking risks today to support democracy and freedom in their countries.

Ype Driessen en Botte Jellema nemen het nieuws door. Er is post over de homofobie van Ché Guevara en Ype vertelt over het boek 'Judas' van Astrid Holleeder. Het graf van Wubbo Ockels is spuuglelijk en wie weet eigenlijk waar Frans Kellendonk precies ligt? De krant van drie maanden geleden kwam uit op Prinsjesdag, maar dat laten we links liggen. Ype trekt een pleister los en Botte overweegt naar BNR te gaan. en dat allemaal in een kleine anderhalf uur! Shownotes - Ariane Schluter: http://www.arianeschluter.nl - Judas - Astrid Holleeder: https://www.bol.com/nl/p/judas/9200000068978371/ - Podcast van Rutger Bregman en Jesse Frederik: https://soundcloud.com/de-correspondent/sets/r-f-show - Maxim Februari in de Zomeravonden: http://www.vpro.nl/speel~POMS_VPRO_378972~zomeravonden-maxim-februari-de-avonden~.html - Column Maxim Februari op Blendle https://blendle.com/i/nrc-handelsblad/geen-recht-op-onderwijs-als-je-je-nieren-niet-afstaat/bnl-nrc-20160920-1_16_1 - Initiatiefvoorstel-Pia Dijkstra https://www.eerstekamer.nl/wetsvoorstel/33506_initiatiefvoorstel_pia - Eed van Hippocrates https://www.eerstekamer.nl/wetsvoorstel/33506_initiatiefvoorstel_pia - Graf van Wubbo Ockels http://www.dvhn.nl/groningen/Vlieger-met-zonnepanelen-op-graf-Wubbo-Ockels-21420997.html - Bol van vuur: http://www.dub.uu.nl/3hoog/2016/12/07/3hoog-marketing.html?_s2m=normal

Markarian 421 (Mrk~421) is one of the classical blazars at X-ray and very high energies (VHE; $>$100 GeV). Its spectral energy distribution (SED) can be accurately characterized by current instruments because of its close proximity, which makes Mrk~421 one of the best sources to study the nature of blazars. The goal of this PhD thesis is to better understand the mechanisms responsible for the broadband emission and the temporal evolution of Mrk~421. The results might be applied to other blazars which cannot be studied with this level of detail because their emissions are weaker, or they are located further away. This thesis reports results from $sim$70 hours of observations with MAGIC in 2010 and 2011 (the first two years of the operation of the MAGIC stereo telescopes), as well as the results from the multi-wavelength (MW) observation campaigns in 2010 and 2011, where more than 20 instruments participated, covering energies from radio to VHE. The MW data from the 2010 and 2011 campaigns show that, for both years, the fractional variability $F_{rm var}$ increases with the energy for both the low-energy and the high-energy bumps in the SED of Mrk~421. Furthermore, $F_{rm var}(text{optical})$ was similar to $F_{rm var}(text{HE-$gamma$-ray;$>$100 MeV})$, and $F_{rm var}(text{X-ray})$ was similar to $F_{rm var}(text{VHE-$gamma$-ray})$. This observed characteristic is expected from the strong correlation between the synchrotron photons and the up-scattered photons by inverse-Compton effect within the synchrotron self-Compton (SSC) emission model, thus allowing for the first time of the consistency test on this widely used theoretical model. During the MW campaign in 2010, we measured the decay of a flaring activity during 13 days in March. We could perform MW observations every day, which enables an unprecedented characterization of the time-evolution of the radio to $gamma$-ray emission of Mrk~421. The broadband SEDs during this flaring episode, resolved on timescales of one day, were characterized with two leptonic scenarios: a one-zone SSC model, and a two-zone SSC model where one zone is responsible for the quiescent emission while the other (smaller) zone, which is spatially separated from the former one, contributes to the daily-variable emission occurring mostly at X-rays and VHE $gamma$ rays. Both the one-zone SSC and the two-zone SSC models can describe the daily SEDs. However, the two-zone SSC model provides a better agreement to the observed SED at the narrow peaks of the low- and high-energy bumps during the highest activity. The proposed two-zone scenario would naturally lead to the correlated variability in the X-ray and VHE bands without variability in the optical/UV band, as well as to shorter timescales for the variability in the X-ray and VHE bands with respect to the variability in the other bands. This concept of a second small emission region containing a narrow electron spectrum in order to explain the short timescale flaring activity in the X-ray and VHE bands could be generalized to other blazars. The results from the 2010 March flaring activity of Mrk~421 are reported in Sections~ref{LightCurves} -- ref{Discussion}, and they are the main scientific achievement of this PhD thesis. Preliminary results were reported (as an oral contribution) in the 33rd International Cosmic Ray Conference (Rio de Janeiro, July 2013), one of the most prestigious conferences in the field of the VHE astronomy and astro-particle physics in general. The final results (reviewed and approved within the Fermic, MAGIC, and VERITAS Collaborations) have been submitted for publication in the Astronomy and Astrophysics journal in 2014 June. During the MW campaign in 2011, Mrk~421 had an atypically high activity in the optical band, together with a very low state in the X-ray/VHE band. Typically, blazar emission models for Mrk~421 focus on the explanation of the variability in the X-ray and $gamma$-ray bands. This data set is suitable for examining emission models and estimate if they can describe the evolution of the whole broadband SEDs including the variabilities in optical, X-ray, and $gamma$-ray bands. We found that the one-zone SSC model can describe the relatively slow variation of the 2011 broadband SEDs. The modeling of these SEDs shows that the main factor dominating the spectral evolution could be the electron energy distribution (EED), instead of the environmental parameters like the blob size and the Doppler factor. To explain the featured high optical state together with the low X-ray/VHE state, several changes were needed in comparison to the typical state from 2009: a harder power-law index in the first segment in the EED, a lower first break in the EED, and a softer power-law index in the second segment in the EED. Besides, these optical high states had synchrotron peak frequencies 10 times lower than the typical state, while their synchrotron peak energy-fluxes were similar to those of the typical state. On the contrary, the 2010~March flaring activity showed that a high peak energy-flux was accompanied by a high peak frequency in comparison to the typical state, which has also been observed on several other blazars. This contrast showed that the broadband variability in the emission of Mrk~421 during 2011 had a different emph{flavor} with respect to the typical blazar broadband flaring activity. This PhD thesis shows that most variations in the SED of Mrk~421 can be produced through changes in the EED, which could shed light into how particles get accelerated in the vicinity of super-massive black holes, or within the relativistic jets of the active galactic nuclei. However, the results also show a large complexity in the evolution of the broadband (radio to VHE $gamma$-rays) SED. Thus longer and deeper observations are needed to understand what characteristics get repeated over time and hence typical, what characteristics are atypical, and ultimately, whether the lessons learned with Mrk~421 can be extended to high-synchrotron-peaked blazars in general.

ADITI Kapur, is the founder of DeliveryChef.in, one of India's leading e-­‐commerce websites that lets Indians order food for delivery from their neighborhood restaurants. Living abroad and having gone to school in New York City, AdiE was accustomed to the ease and convenience of technology. Hence, she decided to give her own city a liGle makeover with the launch of DeliveryChef in 2010. Since then, it has been growing rapidly and is now Eed to approximately 700 eateries for delivery. See the show notes at TodaysLEadingWomen.com!