Podcast appearances and mentions of jeff karp

Your mind is your most powerful tool. Nesha Pai welcomes Dr. Jeff Karp, a Harvard Medical School professor and author of “LIT: Life Ignition Tools,” to talk about how small, intentional shifts can spark creativity, resilience, and meaningful change.   The key to a more fulfilling life isn't about doing more, but about thinking differently. Dr. Karp explains how simple daily choices—setting an intention, embracing failure, and staying present—can open doors to unexpected growth. He reflects on his own struggles with learning and self-doubt, revealing how they shaped his understanding of resilience and the role of community in personal success.   This conversation challenges the idea that success happens alone. Instead, it's about connection, curiosity, and seeing failure as a stepping stone rather than a setback. If you're looking for ways to shift your mindset and spark real change, join Nesha Pai and Dr. Karp in this episode!   Episode Breakdown: 00:00 Introduction  03:14 Finding Purpose and Creativity 05:00 The Power of Observation and Intention 08:26 The Importance of Being Present 10:48 Practical Tools in LIT 19:05 The Role of Neurodiversity in Society 23:02 Embracing Failure as a Gift 27:04 The Importance of Community in Resilience 30:54 Using Failure to Foster Creativity 33:09 Embracing Imposter Syndrome 38:38 Common Traits of High Performers 41:10 The Concept of Holon 43:10 Setting Intentions for Connection Connect with Dr. Jeff Karp: LinkedIn: https://www.linkedin.com/in/jeffkarpboston/ Instagram: https://www.instagram.com/mrjeffkarp/ X: https://x.com/MrJeffKarp TikTok: https://www.tiktok.com/@jeff_karp Buy Amazon book: https://a.co/d/d6vKYBu   Connect with Nesha:  Instagram: https://www.instagram.com/neshapai/ Website: https://www.neshapai.com/ Facebook: https://www.facebook.com/neshapai LinkedIn: https://www.linkedin.com/in/neshapaicpa Podcast production and show notes provided by HiveCast.fm  

Album 7 Track 4 - Conscious Curiosity: Nature, Resilience & Relationships with/Jeff KarpBrand Nerds - we have a one-of-a-kind guest in the virtual building today! Jeff Karp is an extraordinary professional who spans various lanes of expertise - from engineering, medicine, entrepreneurship, and more. This is an episode where you should have a seat because the jew-els being dropped can't be missed. Here are a few key takeaways from the episode:Nature is the greatest teacherBeing conscious in every momentObserve. Observe. Observe.Prioritize relationships over basic networkingResiliency is key.& so much moreStay Up-To-Date on All Things Brands, Beats, & Bytes on SocialInstagram | Twitter

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden engages in a thought-provoking conversation with Dr. Jeff Karp, exploring the themes of curiosity, neurodiversity, education, and the importance of asking questions. They discuss the value of observation, the nature of reality, and the shift from binary to quantum thinking. The conversation also delves into the significance of intentionality in life, the flow state, and the relationship between energy and money. Ultimately, they reflect on the meaning of longevity and how to create a rich life beyond mere wealth.    Growing up in rural Canada, Jeff Karp was written off by his school because of ADHD and learning differences. He evolved a process for embracing life, embodied by a set of 12 simple holistic tools developed over years of iteration and tinkering to make his unique patterns of thought and behavior work for him. These tools are now the subject of a new book: LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. Jeff is also Head of Innovation at Geoversity, Nature's University, a rainforest bio-leadership training conservancy located in one of the top biodiversity hotspots in the world.  He is a contributing author at Psychology Today, where he writes a blog titled How Do You Think About That, exploring insights on personal growth and innovative thinking. A passionate mentor and biomedical engineering professor at Harvard Medical School and MIT, a Distinguished Chair at Brigham and Women's Hospital, and a fellow of the National Academy of Inventors, he has published over 170 peer-reviewed papers, which have garnered more than 35,000 citations, delivered 400 invited lectures, and holds over 100 patents.    FOR THE AUDIENCE:  * Get Jeff Karp's book to tap into your own innovative potential → https://www.amazon.com/LIT-Natures-Playbook-Energize-Ignite-ebook/dp/B09NW4PGK3   * Use code ‘Podcast10' to get 10% OFF your supplements at our store → https://gladdenlongevityshop.com/     Takeaways    * Curiosity can be ignited by asking the right questions.  * Neurodiversity should be viewed as a strength, not a disorder.  * Education often prioritizes answers over the importance of questions.  * Asking questions is crucial for innovation and problem-solving.  * Observation enhances our connection with the world around us.  * Intentionality in daily choices can lead to a more fulfilling life.  * Understanding the nature of reality requires questioning our assumptions.  * Binary thinking limits our perspective; quantum thinking opens possibilities.  * Flow states can enhance productivity and joy in life.  * True wealth is measured by relationships and experiences, not just money.    Chapters    00:00 Introduction to Curiosity and Learning Challenges  05:12 The Impact of Neurodiversity on Learning  08:11 The Value of Curiosity in Education  10:50 The Importance of Questioning  14:07 The Power of Observation and Questioning  16:51 Assumptions and Perspectives  20:07 Binary vs. Quantum Thinking  22:56 Navigating Trust and Questioning  26:03 The Evolution of Science and Understanding  31:31 Understanding Bias in Information  34:19 The Importance of Open-Mindedness  39:29 Intentional Living and Decision Making  43:37 Creating Joy Through Connection  48:08 The Power of Unfocusing  52:25 Perceiving Energy in Our Environment  57:04 Transforming Money into Energy for Good  01:00:56 Longevity: A Path to Purpose and Impact  01:03:29 Goodbye    To learn more about Jeff and his work:  Website: www.jeffkarp.com   LinkedIn: https://www.linkedin.com/in/jeffkarpboston/  Instagram: https://www.instagram.com/mrjeffkarp/  X: https://x.com/MrJeffKarp     Reach out to us!        Website: https://gladdenlongevity.com/         Email: podcast@gladdenlongevity.com         Facebook: https://www.facebook.com/Gladdenlongevity/        Instagram: https://www.instagram.com/gladdenlongevity/?hl=en         LinkedIn: https://www.linkedin.com/company/gladdenlongevity        YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw      

We sit down with Dr. Jeff Karp, a distinguished chair at Brigham and Women's Hospital, professor at Harvard Medical School and MIT, and upcoming keynote speaker at our 62nd Annual Conference. Dr. Karp discusses his experience with learning disabilities, and how he began ‘thinking about thinking,' and using pattern-recognition to begin to thrive. Dr. Karp shares some of his “Life Ignition Tools,” discusses how learning disabilities still impact him as an adult, addresses the self-shame many with LD can feel, and more. Learn more about our 62nd Annual Conference at: https://ldacon.org/ Visit Dr. Karp's website at: www.jeffkarp.com

TUNE IN TO LEARN:  Discover the secrets of turning nature's design into life-changing and industry-leading innovations with Dr. Jeff Karp, a leading force in medical technology.    Known as a pioneer in tissue adhesives and cancer diagnostics, Dr. Karp draws inspiration from the natural world to drive his groundbreaking work.    A testament to genius insights, Jeff overcame learning differences and founded 13 successful companies. As we explore his book, "LIT: Life Ignition Tools," we'll uncover how you can energize your mind to take more action and spark new ideas for a purpose-driven life.    Unravel the science of activation energy and learn how to harness it to overcome procrastination and boost motivation, achieve personal growth and productivity.    Through relatable anecdotes, we discuss the transformative power of understanding your "why" and the impact of aligning your environment with your goals.    Learn how proximity to the issues you care about can inspire meaningful change, while strategic updates to your surroundings and content consumption can keep you motivated.    Dive into the science of questioning and mastering attention in a world overflooded with distractions.    Dr. Karp shares how asking the right questions can unlock curiosity, deepen learning, and strengthen connections.    We also explore the power of intentional focus, offering techniques to train your mind to manage distractions and enhance concentration.  ...and so much more - listen in and take control of your brain's potential for a fulfilling life, career and more positive impact.    More about Dr. Jeff Karp, a free chapter of his book LIT:  https://www.jeffkarp.com/lit-the-book/    BIO:  Dr. Jeff Karp is a distinguished biomedical engineer and professor at Harvard Medical School and MIT, holding an endowed chair at Brigham and Women's Hospital. His pioneering work in drug delivery, stem cell therapeutics, and medical devices has led to the creation of 13 companies, with multiple products in development or on the market.   Inspired by nature's ingenuity, Dr. Karp's lab has developed groundbreaking technologies for many life-saving medical applications.   His contributions have garnered significant recognition, with over 175 peer-reviewed papers accumulating more than 35,000 citations. He holds over 100 patents. Dr. Karp is a fellow of esteemed organizations, including the National Academy of Inventors, the Royal Society of Canada, and the American Institute for Medical and Biological Engineering.   Beyond his research, Dr. Karp is dedicated to mentoring the next generation of bioengineers, with over 30 trainees from his laboratory securing faculty positions. His personal journey, overcoming learning differences, has inspired his development of 'Life Ignition Tools,' a set of strategies aimed at fostering personal and professional growth, detailed in his book "LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action." TUNE IN!!!      Text Me Your Thoughts and IdeasSupport the show Brought to you by Angela Shurina EXECUTIVE HEALTH AND OPTIMAL PERFORMANCE COACH Change in days - not in years!

A Conversation with Dr. Jeff Karp. How can government leaders learn, connect, adapt, and draw energy from their experiences? What role does intention play in being a successful leader? How can Life Ignition Tools help leaders be more effective? Join host Michael Keegan on This Special Edition of The Business of Government Hour - Leading Through Uncertain Times with Dr. Jeff Karp, author, LIT - Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action.   Learn more about your ad choices. Visit podcastchoices.com/adchoices

A Conversation with Dr. Jeff Karp. How can government leaders learn, connect, adapt, and draw energy from their experiences? What role does intention play in being a successful leader? How can Life Ignition Tools help leaders be more effective? Join host Michael Keegan on This Special Edition of The Business of Government Hour - Leading Through Uncertain Times with Dr. Jeff Karp, author, LIT - Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action.  Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How can government leaders learn, connect, adapt, and draw energy from their experiences? What role does intention play in being a successful leader? How can Life Ignition Tools help leaders be more effective? Join host Michael Keegan on This Special Edition of The Business of Government Hour – Leading Through Uncertain Times with Dr. Jeff […]

After listening to this episode, you're going to understand how to harness the power of your mind in a way you never thought possible.Today, Mel welcomes Dr. Jeff Karp, a world-renowned scientist and innovator, who's here to teach you simple, science-backed methods to unlock your potential, no matter where you're starting from.You'll learn how these tools helped Dr. Karp break free from feeling stuck, reframe challenges, and bring creativity and connection into every area of his life.He'll show you exactly how to use these techniques to sharpen your focus, manage stress, and boost your energy instantly.By the end of this episode, you'll have a toolkit of strategies to help you overcome overwhelm, silence self-doubt, and bring purpose into your daily life.Get ready to unlock your mind, ignite your potential, and transform the way you live.For more resources, including links to the studies mentioned in the episode, click here for the podcast episode page.If you liked this episode on brain health and unlocking your potential, listen to this one next: The #1 Neuroscientist: After Listening to This, Your Brain Will Not Be the SameConnect with Mel: Watch the episodes on YouTubeGet Mel's new book, The Let Them TheoryFollow Mel on Instagram The Mel Robbins Podcast InstagramMel's TikTok Sign up for Mel's personal letter Subscribe to SiriusXM Podcasts+ on Apple Podcasts to listen to ad-free new episodes Disclaimer

What is the role of intentionality in personal and professional growth? In this episode, Jeff Karp discusses the power of intentionality, observation, and diverse thinking in problem-solving. Drawing inspiration from nature's problem-solving mechanisms, Karp emphasizes the importance of diverse teams and an "informal" advisory board. Jeff Karp is a bioengineer, engineer, author, and researcher committed to improving our lives, health, focus, and productive purpose. Key topics that Bill and Jeff explore in this episode: - The concept of bioinspiration and its potential for innovation. - The importance of diversity in teams and problem-solving. - The benefits of building an "informal" advisory board. - The role of intentionality in overcoming challenges and achieving goals. - The power of observation and reflection in personal growth. - The transformative power of failure. - Strategies for managing distractions and harnessing the power of ADHD. - Connecting with nature and attuning to the rhythms of life. Chapters in this episode: (03:07) The Origins of Bioinspiration (11:00) The Superpower of Diversity (15:39) Intentionality (27:42) The Importance of Novelty and Newness (33:18) The TEDMED Talk Experience (45:38) ADHD: Challenge, Superpower, and Distraction Disruptor Thanks to Dr. Jeff Karp for being on the show! Learn more about Jeff: https://www.jeffkarp.com/ Get Jeff's book: “LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action': https://www.amazon.com/dp/B09NW4PGK3 Bill Gallagher, Scaling Coach and host of the Scaling Up Business podcast, is an international business coach who works with C-Suite leaders to achieve breakthrough growth. Join Bill in the Growth Navigator Coaching Program: https://ScalingCoach.com/workshop Bill on LinkedIn: https://www.LinkedIn.com/in/BillGallBill on YouTube: https://www.YouTube.com/@BillGallagherScalingCoach Visit https://ScalingUp.com to learn more about Verne Harnish, our team of Scaling Up Coaches, and the Scaling Up Performance Platform, which includes coaching, learning, software, and summit. We share how the fastest-growing companies succeed where so many others fail. We help leadership teams with the biggest decisions around people, strategy, execution, and cash so that they can scale up successfully and beat the odds of business growth. Did you enjoy today's episode? If so, then please leave a review! Help other business leaders discover Scaling Up Business with Bill Gallagher so they, too, can benefit from the ideas shared in these podcasts.Subscribe via Spotify: https://spoti.fi/3PGhWPJSubscribe via Apple Podcasts: https://apple.co/3PKe00uBill on...

In this episode of THE MENTORS RADIO, Host Tom Loarie talks with Jeff Karp, PhD, one of the most innovative minds in medical science. Jeff is a professor of biomedical engineering at Harvard Medical School and MIT, and he leads the Karp Lab, which has pioneered bio-inspired technologies that have led to the formation of 12 companies. His groundbreaking work includes a tissue glue that can seal holes in a beating heart and a ‘smart needle' that stops automatically upon reaching its target. 
Dr. Jeff Karp has been honored as an Outstanding Faculty Mentor at MIT and as the top graduate student mentor at Harvard-MIT. Jeff is also a Fellow of the National Academy of Inventors. In this episode of THE MENTORS RADIO, Dr. Karp will share insights from his discovery of Life Ignition Tools (LIT)—a toolkit that came from overcoming ADHD and put him on a path for doing great things with his life. Jeff will explain how this toolkit can help people break free perceived constraints and/or autopilot…and it will ignite you for great things as well.  Listen to THE MENTORS RADIO podcast anywhere, any time, on any platform, just click here! SHOW NOTES: JEFF KARP, PhD: BIO: https://www.jeffkarp.com/author/ BOOKS: LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action, by Jeff Karp and Teresa Barker Micro- and Nanoengineering of the Cell Surface (Micro and Nano Technologies), by Jeffrey Karp, Welan Zhao Biology and Engineering of Stem Cell Niches, by Ajaykumar Vishwakarma (Editor), Jeffrey M Karp (Editor) WEBSITES: https://www.jeffkarp.com/ https://www.karplab.net/ SOCIAL MEDIA: Instagram: @mrjeffkarp

Send us a textI this episode I interview Dr. Jeff Karp about how he has overcome challenges in his life and the tools and methods he has used to do so.https://www.jeffkarp.com/Support the showhttps://www.risingphoenixpodcast.com

Jeff Karp went from the back of the class to opening his own research lab at Harvard. In this episode, he explains how he did it — and how the tools he used can help you thrive, too.

Okay, so I'll just say right at the top that my guest today is NOT a parenting expert. He is, however, a neurodivergent researcher, educator, author, and thinker who has some fascinating things to share about helping our kids energize their brains, spark ideas, and ignite action. Dr. Jeff Karp was that young kid who struggled greatly in school because of his learning disabilities, but when a tutor during the summer after second grade asked him this question – how did you think about that? – everything for him changed. He began to be more self-reflective. By thinking about thinking and how he approached learning, he was able to explore and create tools and systems to help him reach his goals both in school and in daily life. Jeff is still thinking about thinking today, and shares his ideas in his fascinating book, LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. ​​After I read his book, I wanted to bring him on the show because he embodies so much of what we talk about here at Tilt – encouraging our kids to understand how their brain works, get curious about their own strengths and gifts, and figure out ways to “hack themselves” so they can design lives that allow them to play to those strengths. As a child, Jeff developed ways to navigate school and life that were based on his curiosity, passion, creativity, and connection to nature. Over the years, he's evolved his approaches into LIT (Life Ignition Tools) and wrote this book to share them with the rest of the world.   About Dr. Jeff Karp Dr. Jeff Karp holds the Distinguished Chair at Brigham and Women's Hospital and is a Professor at Harvard Medical School and MIT. He is an elected fellow of the National Academy of Inventors, Royal Society of Chemistry, American Institute for Medical and Biological Engineering, Biomedical Engineering Society, and the Canadian Academy of Engineering. Specializing in bioinspired medical innovation, Dr. Karp leads a research lab focused on harnessing lessons from nature. He has published over 165 peer-reviewed papers with more than 34,000 citations and has delivered nearly 400 invited lectures. He holds over 100 patents, and his lab's technologies have led to the formation of thirteen companies. His notable innovations include a tissue glue for sealing holes in a beating heart, targeted therapies for osteoarthritis and Crohn's disease, smart needles, a nasal spray that neutralizes pathogens, and immunotherapy approaches for cancer. Dr. Karp is also dedicated to mentoring the next generation of bioengineers. He has received multiple mentoring awards, and 30 of his trainees have secured faculty positions.   Things you'll learn How self-reflection and “thinking about thinking” can lead to transformative experiences and strategies for learning and focus What LIT (life ignition tools) is and how they can be used to support positive shifts and movement How being intentional in your actions and reawakening your senses can deepen your experiences What the LEB (low energy brain) dimmer switch is and how it helps regulate energy levels Why being aware of “bothered awareness” can become a motivator How practicing cycling through your senses helps one connect more deeply with the world and tap into your powerful biology   Resources mentioned Dr. Jeff Karp's author website Dr. Jeff Karp's KarpLab website LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action by Dr. Jeff Karp Jeff's TEDx Talk Insight Outside: Harnessing Nature's Secrets Jeff's TEDx Talk: Turning Failure into Success: 3 principles of Radical Simplicity Switch: How to Change Things When Change is Hard by Chip and Dan Heath Brian Stevenson / Equal Justice Initiative Transcendental Meditation Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Jeff and Peter discuss how to be an entrepreneur in the biomedical field, Jeff's journey with ADHD, and groundbreaking technologies pioneered by Jeff's lab.   21:34 | The Future of Disease Diagnostics 44:54 | A Nasal Spray Against Covid-19? 01:18:26 | Surviving Imposter Syndrome Dr. Jeffrey Karp is a leading bioengineer, holding a professorship at Harvard Medical School and MIT. Karp has co-founded 13 companies, raising over $600 million. His Laboratory ‘Karp Lab' focuses on advanced biomaterials and devices for therapeutics, and focuses on medical problem-solving fields like a nasal spray effective against viruses. Some of the groundbreaking technologies he's developed are tissue adhesives (TISSIUM), target drug delivery needs, and 3D printing biomedical devices. His dedication to bioengineering research has led to over 30,000 citations for his publications (0.1% globally) and multiple awards by the National Academy of Inventors and TEDMED. Dr. Karp's new book: https://www.amazon.com/dp/0063010739 Website: https://www.jeffkarp.com/  Profi Nasal Spray: https://www.profispray.com/  ____________ I only endorse products and services I personally use. To see what they are,  please support this podcast by checking out our sponsors:  Get started with Fountain Life and become the CEO of your health: https://fountainlife.com/peter/ AI-powered precision diagnosis you NEED for a healthy gut: https://www.viome.com/peter  _____________ Get my new Longevity Practices 2024 book: https://bit.ly/48Hv1j6  I send weekly emails with the latest insights and trends on today's and tomorrow's exponential technologies. Stay ahead of the curve, and sign up now:  Tech Blog _____________ Connect With Peter: Twitter Instagram Youtube Moonshots

In this episode, I'm diving deep into the world of biomedical engineering with Dr. Jeff Karp, a renowned professor of medicine at Harvard and an innovator in regenerative medicine. Dr. Karp shares his journey from overcoming ADHD to developing groundbreaking medical technologies inspired by nature. This episode provides insights into how we can harness the principles of nature to solve some of the most complex problems in medicine and beyond. Sponsors: Lume: Control Body Odor ANYWHERE with @lumedeodorant and get 15% off with promo code GABBY at LumeDeodorant.com! #lumepod Timeline is offering 10% off your first order of Mitopure. Go to timelinenutrition.com/GABBY and use code GABBY to get 10% off your order. Are you ready to ditch the guilt and the self-blame and finally achieve the life you deserve? Then grab your copy of "Unstoppable Brain" today! It's available in hardcover, audiobook, and ebook on Amazon.  Main Sections & Timecodes: Introduction to Dr. Jeff Karp and His Journey [00:00:00 - 00:06:00] Gabby introduces Dr. Karp, discussing his background and the significant influence of his ADHD on his career. Innovative Medical Technologies Inspired by Nature [00:06:01 - 00:15:00] Dr. Karp talks about his nature-inspired innovations, such as surgical glues and hearing loss treatments, and how biomimicry plays a crucial role in his research. The Concept of Radical Simplicity [00:15:01 - 00:20:00] Discussion on the importance of simplifying complex scientific concepts to create practical and effective solutions. Resilience and Adaptability in Research [00:20:01 - 00:30:00] Dr. Karp shares his experiences with setbacks and failures in research and how they have led to significant breakthroughs. Applying Scientific Principles to Daily Life [00:30:01 - 00:40:00] Practical advice on how to use scientific principles to enhance everyday life, including tips on managing mental health and fostering curiosity. Connecting with Nature and Enhancing Sensory Awareness [00:40:01 - End] Dr. Karp discusses the importance of connecting with nature and improving sensory awareness to enhance overall well-being. Want to learn more from Dr. Karp, check out his book LIT: Life Ignition Tools: https://www.jeffkarp.com/ Everything Gabby Reece: Instagram: https://www.instagram.com/gabbyreece/ TikTok: https://www.tiktok.com/@gabbyreeceofficial Facebook: https://www.facebook.com/OfficialGabrielleReece/ Gabby Reece Website - https://gabriellereece.com/ Gabby Reece Show Transcript: https://gabriellereece.com/podcast/ The Gabby Reece Show Podcast on Youtube: https://www.youtube.com/channel/UCeEINLNlGvIceFOP7aAZk5A Gabrielle 'Gabby' Reece is an American actress, podcaster, and former model and professional volleyball player best known for hosting a lifestyle, health & fitness podcast titled The Gabby Reece Show. Additionally, she is the co-founder of XPT | Extreme Performance Training and Laird Superfood alongside her husband and big wave surfer Laird Hamilton. The Gabby Reece Show talks to top experts with the goal of extracting the best information you will need to navigate the universe of health, fitness, relationships, parenting, and business. Gabby keeps it simple but gets to the heart of the conversation with the hopes of providing you with realistic takeaways. Thank you for tuning into "The Gabby Reece Show." If you found this information helpful, consider sharing this episode with someone who needs it. And subscribe to make sure you never miss informative conversations like this. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today, Emily Kircher-Morris talks with Dr. Jeff Karp. Jeff is a professor at Harvard and MIT, a biotech entrepreneur, and an ADHD-er. They talk about Jeff's program, LIT, or Life Ignition Tools, which is a set of strategies to energize the brain, spark ideas, and ignite action. Emily and Jeff talk about metacognition and the transformative impact it can have on the lives of neurodivergent people. They also discuss the importance of intentional actions, the power of asking questions, the necessity of creating a supportive and dynamic learning environment, and the broader implications of neurodiversity in educational and professional settings. There's practical advice for educators, parents, and individuals, to leverage their unique strengths and foster an inclusive and innovative society, and much more, on episode 231. This episode is brought to you by Next Step Navigators, where you can take your ADHD coach to college with you. NextStep Navigators can support  you from any campus. Visit NextStepNavigators.com Get signed up for the live, free continuing education training, Foundations of Neurodiversity-Affirming Therapy, on Friday, July 12th. Join the Neurodiversity Podcast Advocacy and Support Group on Facebook. Dr. Jeff Karp is an acclaimed mentor and biomedical engineering professor at Harvard Medical School and MIT, a Distinguished Chair at Brigham and Women's Hospital, and a fellow of the National Academy of Inventors. Growing up in rural Canada, he was written off by his school because of his learning differences. He evolved, and developed his own process for embracing life, embodied by ‘Life Ignition Tools' - tools he developed through years of iteration and tinkering, to make his unique patterns of thought and behavior work for him. These LIT tools have been tested in his lab, and by his many mentees. He has dedicated his research to bioinspired medical problem-solving, and his lab's technologies have led to the formation of thirteen companies. Dr. Karp is also head of innovation at Geoversity, Nature's University, a rainforest biocultural leadership training conservancy located in one of the top biodiversity hotspots in the world. He was selected as the Outstanding Faculty Undergraduate Mentor among all faculty at MIT, and the top graduate student mentor of Harvard-MIT students. Dr. Karp lives in Brookline, Massachusetts, with his wife, children, and two Cavalier King Charles spaniels. BACKGROUND READING LinkedIn Instagram Twitter/X Dr. Karp's website

The natural world has provided inspiration to poets, artists, and creatives of every ilk. And that includes inventors and innovators like Dr. Jeff Karp. In this podcast, Tami Simon speaks with the renowned biomedical engineer and founder of The Karp Lab about his new book, LIT (Life Ignition Tools): Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action, and how you yourself can turn to the natural world as an ally for problem-solving, unexpected insight, and profound transformation on a daily basis. Enjoy this incredibly inspiring conversation exploring: The work of the "bioinspirationalist"; how sandcastle worms inspired a new approach to vascular reconstruction in humans; the LIT state and how we can open ourselves up to limitless possibilities in any situation; the pendulum swing between "dull moments" and the times we are totally lit up; the life force within everything; the importance of changing up our routines; LEB (low energy brain); the "press pause" tool of LIT; working with intention; elevating your baseline feeling of wellness and fulfillment; viewing the world through the lens of energy transfer; how we are all contributing to evolution; the practice of cycling through your senses; appreciating our interconnectedness; creating space; aligning your thoughts and actions with your core values; turning negatives into positives; finding rituals and practices to enter into the LIT state; mining the treasures of neurodiversity; and more. Note: This episode originally aired on Sounds True One, where these special episodes of Insights at the Edge are available to watch live on video with exclusive access to Q&As with our guests. Learn more at join.soundstrue.com.

The natural world has provided inspiration to poets, artists, and creatives of every ilk. And that includes inventors and innovators like Dr. Jeff Karp. In this podcast, Tami Simon speaks with the renowned biomedical engineer and founder of The Karp Lab about his new book, LIT (Life Ignition Tools): Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action, and how you yourself can turn to the natural world as an ally for problem-solving, unexpected insight, and profound transformation on a daily basis. Enjoy this incredibly inspiring conversation exploring: The work of the "bioinspirationalist"; how sandcastle worms inspired a new approach to vascular reconstruction in humans; the LIT state and how we can open ourselves up to limitless possibilities in any situation; the pendulum swing between "dull moments" and the times we are totally lit up; the life force within everything; the importance of changing up our routines; LEB (low energy brain); the "press pause" tool of LIT; working with intention; elevating your baseline feeling of wellness and fulfillment; viewing the world through the lens of energy transfer; how we are all contributing to evolution; the practice of cycling through your senses; appreciating our interconnectedness; creating space; aligning your thoughts and actions with your core values; turning negatives into positives; finding rituals and practices to enter into the LIT state; mining the treasures of neurodiversity; and more. Note: This episode originally aired on Sounds True One, where these special episodes of Insights at the Edge are available to watch live on video with exclusive access to Q&As with our guests. Learn more at join.soundstrue.com.

Jeff Karp is the President and Co-Founder of LAZ Parking LLC, the largest privately held parking operator in the country. Jeff founded LAZ Parking in 1981 and LAZ currently operates over 4,000 locations, in 452 cities and 41 states across the country. With a dedicated and passionate employee base of over 14,000 strong committed to a superior customer service experience, LAZ has been propelled into being a leader in its field. With $2.0 billion in annual revenue, LAZ Parking strives for a best in class culture, focused on conscious capitalism rooted within ESG and Diversity, Equity and Inclusion. Jeff is also a Founder and Principal Partner in LAZ Parking Reality Investors (LPRI), a vertically integrated real estate platform focused on parking assets nationally. Their mission is to identify, diligence, and acquire parking assets nationwide; finding opportunities to add value through experienced ownership and operation. LPRI's experience extends over virtually every type of parking asset, from simple surface lots to complex mixed-use garages, and includes assets whose primary demand comes from office, retail, residential, hotels, sporting events and airports.In addition to his business affiliations, Jeff is an active civic leader and strong supporter and board member of various charitable organizations such as the Special Olympics, Chabad House, Jewish Big Brother Big Sister, Crossroads for Kids, Save the Harbor, National Parking Association, Anti-Defamation League, Combined Jewish Philanthropies, Meriting Attention, and the American Cancer Society.We really enjoyed our discussion with Jeff, and the story behind the LAZ Parking empire did not disappoint. As discussed during the interview, it seems we can't travel a block or two without coming across a LAZ location. Jeff was candid in sharing the many highs and lows of his entrepreneurial journey, which he has been on alongside his two co-founders who happen to be his boyhood best friends. We learned a lot from Jeff about the operational side of parking business, a sector in which our Boston capital markets team has been increasingly active over the past several years and one that intrigues many real estate practitioners.For more info on LAZ Parking, please visit: www.lazparking.comPlease share with clients, colleagues and friends and thanks for tuning in!Tom Greeleyhttps://www.linkedin.com/in/thomasgreeley/tom.greeley@nmrk.comMike Greeleyhttps://www.linkedin.com/in/michaelgreeley1Michael.greeley@nmrk.com

In this insightful podcast episode, Dr. Jeff Karp shares powerful strategies to tap into your brain's neuroplasticity and rewire it for success. Discover how small changes in your daily life can lead to significant improvements in creativity, problem-solving, and overall well-being. Learn to intercept routine patterns and algorithms that limit your potential, and embrace a mindset of continuous learning and growth. Dr. Karp's new book, called LIT: Life Ignition Tools and his research at Harvard Medical School and MIT provides a scientific foundation for these life-changing techniques. Learn more about your ad choices. Visit megaphone.fm/adchoices

 We all could use tips on how to stop scrolling and pay better attention to the world around us. Jeff Karp is a biomedical engineering professor at Harvard Medical School and MIT, a Distinguished Chair at Brigham and Women's Hospital, and a fellow of the National Academy of Inventors. He joins host Krys Boyd to discuss his strategies for lengthening attention span coming from his experience with significant ADHD, and offers advice on how to put down our devices. His book is “LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action.”

How can government leaders learn, connect, adapt, and draw energy from their experiences? What role does intention play in being a successful leader? How can Life Ignition Tools help leaders be more effective? Join host Michael Keegan on This Special Edition of The Business of Government Hour – Leading Through Uncertain Times with Dr. Jeff […]

Join us as host Will Braunstein sits down with Dr. Jeff Karp, a Harvard Medical School professor, MIT biomedical engineer, and author of the inspiring new book "LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action"  Dr. Karp explores how parents can harness the power of nature to boost productivity for themselves and their children. Dr. Karp shares practical tools that tap into the natural world to rejuvenate our mental landscapes and foster focus and creativity.  Whether it's overcoming distractions or aligning daily tasks with our deepest values, this episode provides actionable insights for parents eager to cultivate a focused, energized, and purpose-driven family life.  Tune in to discover how you can light up your life and guide your children in kindling their own sparks of productivity and fulfillment. You can learn more about Dr. Karp's work at https://www.karplab.net

What if overcoming challenges and living an extraordinary life is simpler than you think? Jeff Karp shares his unlikely journey from a struggling student to pioneering Harvard professor and serial entrepreneur. Jeff developed a toolbox of “life ignition” practices to unlock creativity and possibility, despite learning differences. He reveals how embracing curiosity transformed his work and relationships. We explore tools to spark ideas, reframe failure, and lower the “activation energy” for change. Jeff explains how he turned to nature for inspiration to overcome setbacks in the lab, leading to breakthrough innovations. Discover how small mindset shifts can unlock your innate potential. Jeff Karp's new book is LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action.You can find Jeff at: Website | LinkedIn | Episode TranscriptIf you LOVED this episode you'll also love the conversations we had with Ozan Varol about drinking in life and making big things happen.Check out our offerings & partners: My New Book SparkedMy New Podcast SPARKED. Visit Our Sponsor Page For Great Resources & Discount Codes Hosted on Acast. See acast.com/privacy for more information.

This episode is brought to you by LMNT and Timeline Nutrition. Ever felt like your brain could use a jumpstart to break free from the mundane? Jeff Karp, PhD joins me to unravel the marvels of neuroplasticity and the transformative LIT method. Together, we dissect the brain's innate ability to shift from a state of lethargy to one brimming with creativity and action. Dr. Karp, a pioneer in regenerative medicine, shares his expertise on restoring our bodies to peak function and equips us with practical tools to energize our minds. From the healing embrace of nature to redefining our relationship with fear and failure, we delve into habits that can significantly enhance our cognitive and emotional landscape. Follow Jeff @mrjeffkarp Follow Chase @chase_chewning ----- In this episode we discuss... (00:00) What Is Neuroplasticity? (15:11) Mindfulness and Intention MATTER (25:40) Benefits of Nature Connection  (30:42) Unlocking Potential Through the LIT Method (36:59) Rediscovering Life After Obstacles and Maintaining Priorities Through Adversity (41:55) Unlocking Potential Through Small Steps (52:29) Practicing Gratitude and Disrupting Patterns (01:02:28) Innovative Technologies in Healthcare and Healthspan  (01:10:54) Navigating Failure and Radical Simplicity (01:24:33) Ever Forward ----- Episode resources: FREE variety sample pack with any purchase of electrolytes at https://www.DrinkLMNT.com/everforward Save 10% on MitoPure mitochondrial revitalizer with code EVERFORWARD at https://www.TimelineNutrition.com/everforward  Watch and subscribe on YouTube Get LIT: Life Ignition Tools book or free audiobook with your new 30-day trial of Audible

My guest today is Jeff Karp, a Canadian biomedical engineer working as a Professor of Medicine at Harvard Medical School, Brigham and Women's Hospital, and the principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the Massachusetts Institute of Technology through the Harvard–MIT Division of Health Sciences and Technology. In 2008, he was listed as one of the top innovators. In 2011, he received Young Investigator award from the Society for Biomaterials, and the Champion in Health Care Innovation. The topic is his book LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. In this episode of Trend Following Radio we discuss: Personal growth and overcoming obstacles Brain's ability to adapt and learn, particularly in individuals with learning differences Connection between physical activity, brain function, and emotional well-being Activation energy in achieving goals Incremental progress Importance of patterns and habits Neurodiversity and curiosity Dealing with failure and maximizing momentum Jump in! --- I'm MICHAEL COVEL, the host of TREND FOLLOWING RADIO, and I'm proud to have delivered 10+ million podcast listens since 2012. Investments, economics, psychology, politics, decision-making, human behavior, entrepreneurship and trend following are all passionately explored and debated on my show. To start? I'd like to give you a great piece of advice you can use in your life and trading journey… cut your losses! You will find much more about that philosophy here: https://www.trendfollowing.com/trend/ You can watch a free video here: https://www.trendfollowing.com/video/ Can't get enough of this episode? You can choose from my thousand plus episodes here: https://www.trendfollowing.com/podcast My social media platforms: Twitter: @covel Facebook: @trendfollowing LinkedIn: @covel Instagram: @mikecovel Hope you enjoy my never-ending podcast conversation!

My guest today is Jeff Karp, a Canadian biomedical engineer working as a Professor of Medicine at Harvard Medical School, Brigham and Women's Hospital, and the principal faculty at the Harvard Stem Cell Institute and Affiliate Faculty at the Massachusetts Institute of Technology through the Harvard–MIT Division of Health Sciences and Technology. In 2008, he was listed as one of the top innovators. In 2011, he received Young Investigator award from the Society for Biomaterials, and the Champion in Health Care Innovation. The topic is his book LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. In this episode of Trend Following Radio we discuss: Personal growth and overcoming obstacles Brain's ability to adapt and learn, particularly in individuals with learning differences Connection between physical activity, brain function, and emotional well-being Activation energy in achieving goals Incremental progress Importance of patterns and habits Neurodiversity and curiosity Dealing with failure and maximizing momentum Jump in! --- I'm MICHAEL COVEL, the host of TREND FOLLOWING RADIO, and I'm proud to have delivered 10+ million podcast listens since 2012. Investments, economics, psychology, politics, decision-making, human behavior, entrepreneurship and trend following are all passionately explored and debated on my show. To start? I'd like to give you a great piece of advice you can use in your life and trading journey… cut your losses! You will find much more about that philosophy here: https://www.trendfollowing.com/trend/ You can watch a free video here: https://www.trendfollowing.com/video/ Can't get enough of this episode? You can choose from my thousand plus episodes here: https://www.trendfollowing.com/podcast My social media platforms: Twitter: @covel Facebook: @trendfollowing LinkedIn: @covel Instagram: @mikecovel Hope you enjoy my never-ending podcast conversation!

In this episode, we visit with Rebecca Seidel, president of Medtronic's cardiac ablation solutions group, about the future of pulsed-field ablation and what it means for the electrophysiology sector. Host Tom Salemi also visits with biomedical researcher Jeff Karp to discuss his new book, LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action Kindle Edition. Use the code LIT25 to save 25% off the registration price of DeviceTalks Boston and you could win a free copy. Karp will also be at DeviceTalks Boston's opening reception on April 30. Come meet the author and noted medtech innovator. Finally, we get a #DTBoston2024 speaker preview – Scott Nelson, CEO of FastWave Medical, one of two IVL companies we'll have at the conference! Thank you to Freudenberg Medical for sponsoring this episode. Go to Freudenbergmedical.com for more information. Thank you for listening to the DeviceTalks Weekly Podcast. Subscribe to the DeviceTalks Podcast Network

Being diagnosed with something like ADHD can feel like you're carrying a huge sign that says “I can't focus”. And in a world that's not built to accommodate neurodiversity, achieving your dreams can feel impossible. So how do you work with your neurodivergence to create a life full of success?  In this episode of Habits & Hustle, I'm joined by Jeff Karp, PhD as we discuss the challenges of not being diagnosed with ADHD until 7th grade while being determined to not be held back at school. He also shares his story of becoming an esteemed academic in an academic world that didn't suit him and what that taught him about the power of determination and perseverance. We also discuss methods to managing distractions in a world built to distract us, the profound personal evolution that hit through COVID, and how to break the negative patterns that no longer serve us.   Jeff Karp is a Harvard Medical School professor with a PhD in biomedical engineering at Toronto and did a postdoc in biomaterials at MIT. Diagnosed with ADHD and learning differences in 7th grade, he defied expectations through unwavering perseverance and determination. His lab, The Karp Lab, works on innovative projects like creating an adhesive to repair hearts. What we discuss… (00:00) Navigating natural curiosity and focus in the world of academia  (19:35) How to improve attention and reduce distractions  (30:04) The power of transcendental meditation and listening in  (35:22) Personal growth and reevaluating priorities during COVID  (41:46) Unlocking your energy with holistic wellness (50:51) How to deepen connection through conscious awareness  (01:04:20) Improving relationships through self-reflection and understanding your patterns (01:11:26) Starting and running a research lab, and navigating funding  (01:27:43) Morning rituals for health and productivity  …and more! Thank you to our sponsors: Therasage: go to therasage.com and use code B-BOLD for 15% off Pendulum: head over to pendulumlife.com and use my special code HUSTLE15 for 15% off your order. Find more from Jen:  Website: https://www.jennifercohen.com/ Instagram: @therealjencohen  Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Find more from Jeff: Website: jeffkarp.com LinkedIn: https://www.linkedin.com/in/jeffkarpboston/ Order the Book: https://a.co/d/2AVXLz1

Do you ever feel bored or stuck in a rut? If so, you're not alone. It's easy to go through life on autopilot. But inventor, author, and Harvard professor Jeff Karp says it doesn't have to be that way. Jeff is a biomedical engineer who has invented many interesting things. He's also the author of a new book called LIT: Life Ignition Tools. Some of the things he shares today are how to spark new ideas, solve problems creatively, and find new things to do. Links & Resources JeffKarp.com LIT: Life Ignition Tools Subscribe to Mentally Stronger Premium — Get weekly bonus episodes, monthly bonus content, and cool gifts (like signed books)! Offers From Our Sponsors Shopify — Sign up for a $1/month trial period at shopify.com/mentallystronger Connect with the Show Buy Amy's books on mental strength Connect with Amy on Instagram — @AmyMorinAuthor Email the show — Podcast@AmyMorinLCSW.com Order 13 Things Mentally Strong Couples Don't Do

Dr. Jeff Karp is a Harvard Medical School professor and bioengineer. He works in the fields of drug delivery, medical devices, stem cell therapeutics, and tissue adhesives and has been recognized by MIT as being one of the top innovators in the world. He talks with Paul about his work, his relationship with nature, and how life led him to where he is now. Watch for his new book, LIT* Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite ActionFor more about Dr. Karp go to www.JeffKarp.comWAYS TO HELP THE MIHH PODCASTSubscribe via iTunes and leave a review. It costs nothing. https://itunes.apple.com/us/podcast/mental-illness-happy-hour/id427377900?mt=2Spread the word via social media. It costs nothing.Our website is www.mentalpod.com our FB is www.Facebook.com/mentalpod and our Twitter and Instagram are both @Mentalpod Become a much-needed Patreon monthly-donor (with occasional rewards) for as little as $1/month at www.Patreon.com/mentalpod Become a one-time or monthly donor via PayPal at https://mentalpod.com/donateYou can also donate via Zelle (make payment to mentalpod@gmail.com) To donate via Venmo make payment to @Mentalpod Try Our Sponsor's Products/ServicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

We want a more intentional life...but HOW do we create it?"Bioinspirationalist" and researcher Dr. Jeff Karp shares life ignition strategies that act as specific catalysts for personal growth and intentional living. Our culture atomizes our attention. It cubes our time, and it flattens our imagination. - Dr. Jeff KarpGet the book! Life Ignition Tools (LIT)Show notes: https://www.onairella.com/post/339-life-ignition-toolsFull transcript available here.DOWNLOAD the "Live Better Wheel" life assessment (free)-----------------------------------CONNECT WITH ELLA:@onairwithella www.onairella.com☎️ Leave a voice message: +1 (202) 681-0388 -------------------------------

When I'm interviewed on other people's shows about drive, often the first topic they'll bring up is my claim that everyone has drive. Further, that everyone has just as much drive in them as anyone else. When I explain it, everyone agrees and accepts this new revelation. However, in this space of self-improvement, I bristle at the concept of “no fear” and “no limits” and “no excuses.” This is the perception I embraced as a kid and took into my life. It was great as a pro cyclist where you push yourself past your limits. But overall in life, to disregard the truth of our weaknesses and limitations is foolish. I know. I have been a fool so many times. In my recent show with Harvard and MIT professor Jeff Karp, his story starts with tremendous difficulties as a kid in school. They wanted to hold him back in 2nd grade. His grades were terrible. He was labeled a troublemaker. He was embarrassed by teachers in front of his class. What I appreciate is he didn't just justify all his issues. He accepted them and said, “Yes, I really have trouble with my attention and how my brain does and doesn't work.” And he didn't justify it with his ultimate success as an Ivy League professor. He just took it all scientifically and spiritually and said, “Hey, here are some tools I figured out that can help you, like they helped me.” We do have personal weaknesses. We do have limits. We do have things we will always struggle with, and they do matter. Drive with me a moment and let's talk about how we can progress and succeed anyway. With growth, grit, and grace.  Head to airdoctorpro.com and use promo code KEVIN and depending on the model receive UP TO 39% off or UP TO $300 off! Sign up for a one-dollar-per-month trial period at shopify.com/kevin Use promo code KEVIN today at shipstation.com to sign up for your FREE 60-day trial. Visit Audible.com/whatdrivesyou or text whatdrivesyou to 500-500. Go to HelloFresh.com/drivefree and use code drivefree for FREE breakfast for life! Go to Seed.com/DRIVE and use code DRIVE to get 25% off your first month  Visit BetterHelp.com/WHATDRIVESYOU today to get 10% off your first month. Available Nationally, look for a bottle of Heaven Hill Bottled-in-Bond at your local store. Find out more at heavenhilldistillery.com/hh-bottled-in-bond.php Go to https://prolonlife.com/kevin and get TEN PERCENT off Prolon Life's 5-day nutrition program Learn more about your ad choices. Visit megaphone.fm/adchoices

Think about all the “shoulds” in your life. All the things that come to mind that you should do, and that feeling of, “ugh”. And the feeling of, “I know I should, but…” and there is a list of things to do you don't even have conceptualized. It just feels like a lot. And it can keep us stuck there. Idling in park and not driving…anywhere. Driven, but stuck. This happened to me the other day and I tried something that worked. Then low and behold the very next day the concept was scientifically defined for me by Harvard and MIT professor Jeff Karp as we talked about the message in his new book, LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. The concept is called “lowering activation.” Drive with me a moment and I'll unpack it so you can use it too. Head to airdoctorpro.com and use promo code KEVIN and depending on the model receive UP TO 39% off or UP TO $300 off! Sign up for a one-dollar-per-month trial period at shopify.com/kevin Use promo code KEVIN today at shipstation.com to sign up for your FREE 60-day trial. Visit Audible.com/whatdrivesyou or text whatdrivesyou to 500-500. Go to HelloFresh.com/drivefree and use code drivefree for FREE breakfast for life! Go to Seed.com/DRIVE and use code DRIVE to get 25% off your first month  Visit BetterHelp.com/WHATDRIVESYOU today to get 10% off your first month. Available Nationally, look for a bottle of Heaven Hill Bottled-in-Bond at your local store. Find out more at heavenhilldistillery.com/hh-bottled-in-bond.php Go to https://prolonlife.com/kevin and get TEN PERCENT off Prolon Life's 5-day nutrition program Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dr. Jeff Karp, a renowned biomedical engineer and professor, shares his journey of overcoming learning differences and the impactful strategies he developed to harness his potential. Dr. Karp, a member of the National Academy of Inventors and a celebrated mentor at Harvard Medical School and MIT, has dedicated his research laboratory to bioinspired medical problem-solving. His work has led to the creation of groundbreaking technologies, from a nasal spray to neutralize pathogens to a tissue glue that can seal holes inside a beating heart. Throughout the conversation, Dr. Karp delves into his experiences from his early struggles in the second grade to his current innovative work. He details the transformative moment of realizing that he could think about thinking and how this insight led him to develop a set of tools for understanding and navigating the world. He also discusses the importance of asking questions, challenging assumptions, and exploring new approaches to problems. Some highlights we explore: Dr. Karp's early struggles with undiagnosed ADHD and learning differences, and the transformative question that changed his life. The process of medical problem-solving that Dr. Karp's lab focuses on, and some of the innovative technologies they have developed. How Dr. Karp's principles can help anyone redirect their lives with energy, focus, creativity, and intention. The importance of recognizing manipulative messaging and managing information overload. Enjoy!

Join us as we explore the transformative journey of lifelong learning, where the pursuit of knowledge reshapes our very being. As we discuss, learning is not static; it's an ever-evolving process that requires us to reassess the foundations of our understanding and embrace the idea that our knowledge and beliefs are as malleable as astronauts defining 'down' in space. In this episode, we dissect the art of inquiry, emphasizing the potency of asking the right questions, whether in scientific seminars or everyday conversations. By understanding the importance of well-crafted questions, we can transform superficial interactions into meaningful exchanges, uncovering the strategic narratives of those around us. Jeff shares how inspiration from nature led to groundbreaking medical products, exemplifying the importance of maintaining a keen observational eye. Further, we examine how mindfulness and observation can rekindle our innate curiosity, deepen our connection with the environment, and reveal the miraculous in everyday life. So, take a moment to pause, listen, and let yourself be inspired by the wonders that surround us and the infinite possibilities of continued growth and discovery. Buy Jeff's book. Follow Jeff on LinkedIn, and X. Join my weekly newsletter. Learn more about my books and courses. Join The Essentialism Academy. Follow me on LinkedIn, Instagram, X, Facebook, and YouTube. Learn more about your ad choices. Visit megaphone.fm/adchoices

Take every self-help resource. Every therapy session. Every spiritual resource. From them all we are striving to program, or reprogram, our brains. In order to get us driving further and faster with less effort. Less anxiety. Less complexity. Less limits. Saying life is a mind game can be incredibly depressing, or empowering. My goal in this short message is to empower you. And me. I need this reminder every day. We all live in our own, personal matrix. We really do. Understanding, embracing, and accepting this can be life altering. My inspiration is Harvard and MIT professor Jeff Karp who I just had on the show. His new book, LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action, is a great showcase in how life is a mind game and how we can intentionally get ourselves LIT for success. Drive with me a moment… Head to airdoctorpro.com and use promo code KEVIN and depending on the model receive UP TO 39% off or UP TO $300 off! Sign up for a one-dollar-per-month trial period at shopify.com/kevin Use promo code KEVIN today at shipstation.com to sign up for your FREE 60-day trial. Visit Audible.com/whatdrivesyou or text whatdrivesyou to 500-500. Go to HelloFresh.com/drivefree and use code drivefree for FREE breakfast for life! Go to Seed.com/DRIVE and use code DRIVE to get 25% off your first month  Visit BetterHelp.com/WHATDRIVESYOU today to get 10% off your first month. Available Nationally, look for a bottle of Heaven Hill Bottled-in-Bond at your local store. Find out more at heavenhilldistillery.com/hh-bottled-in-bond.php Go to https://prolonlife.com/kevin and get TEN PERCENT off Prolon Life's 5-day nutrition program Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week's episode of Enneagram IRL, we meet with Jeff Karp, Ph.D., acclaimed mentor and biomedical engineering professor at Harvard Medical School and MIT, a Distinguished Chair at Brigham and Women's Hospital. As a child, his teacher wanted to hold him back in the second grade. As an adult, he got his PhD, became a celebrated Professor and member of the National Academy of Inventors, and a Distinguished Chair at Brigham and Women's Hospital where he has co-founded twelve companies, amassed over 100 patents and received 50 awards.Fueled by his Life Ignition Tools, 'LIT', Jeff turned to nature for inspiration to revolutionize lab practices. Now, Jeff is sharing his lessons in his debut book. LIT aims to empower others to take themselves off autopilot and unlock their own reservoirs of potential. Grab a copy of LIT: Life Ignition Tools here!

Most of us think we are driving through our lives with automatic shifting, like almost all cars nowadays. But in truth, our life is a stick shift and we must manually shift gears. And most of us habitually live in first to third gear. We go about living in our minds with a lot of limitations, blind spots, and ignorance. So I bring you, Jeff Karp. Jeff started life with some big struggles. Amidst some undiagnosed issues, he did so poorly in school they wanted to hold him back in second grade. Teachers literally put blinders on him and embarrassed him in front of class for not paying attention. He was labeled a troublemaker. But at age eight a teacher asked him about how he was thinking, and it opened up such a new world for Jeff that he cites it as his first spiritual experience. He went on to adjust how he learned and today is a member of the National Academy of Inventors. He is a Professor at Harvard Medical School and MIT and a Distinguished Chair at Brigham and Women's Hospital. Dr. Karp has dedicated his research laboratory to bioinspired medical problem solving, which he explains at the top of the show as studying phenomena in nature and replicating them through science. His lab's technologies include a nasal spray to neutralize pathogens, a tissue glue that can seal holes inside a beating heart, targeted therapy for osteoarthritis and inflammatory bowel disease, needles that automatically stop when they reach their target, and more. His new book however is focused on you and your brain and the vast, untapped potential he says you can ignite with some tools. And you can upshift in your life. Drive further and faster with less effort. The book is called LIT, which stands for Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. Some would call it brain hacks but it's not. It's just brain ability we generally are unaware of. So join me in a conversation to learn more about how you can utilize some tools to get your brain…LIT. You can learn more at Dr. Karp's website here: www.jeffkarp.com Head to airdoctorpro.com and use promo code KEVIN and depending on the model receive UP TO 39% off or UP TO $300 off! Sign up for a one-dollar-per-month trial period at shopify.com/kevin Use promo code KEVIN today at shipstation.com to sign up for your FREE 60-day trial. Visit Audible.com/whatdrivesyou or text whatdrivesyou to 500-500. Go to HelloFresh.com/drivefree and use code drivefree for FREE breakfast for life! Go to Seed.com/DRIVE and use code DRIVE to get 25% off your first month  Visit BetterHelp.com/WHATDRIVESYOU today to get 10% off your first month. Available Nationally, look for a bottle of Heaven Hill Bottled-in-Bond at your local store. Find out more at heavenhilldistillery.com/hh-bottled-in-bond.php Go to https://prolonlife.com/kevin and get TEN PERCENT off Prolon Life's 5-day nutrition program Learn more about your ad choices. Visit megaphone.fm/adchoices

How can government leaders learn, connect, adapt, and draw energy from their experiences? What role does intention play in being a successful leader? How can Life Ignition Tools help leaders be more effective? Join host Michael Keegan on This Special Edition of The Business of Government Hour - Leading Through Uncertain Times with Dr. Jeff Karp, author, LIT - Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action.  Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How can government leaders learn, connect, adapt, and draw energy from their experiences? What role does intention play in being a successful leader? How can Life Ignition Tools help leaders be more effective? Join host Michael Keegan on This Special Edition of The Business of Government Hour - Leading Through Uncertain Times with Dr. Jeff Karp, author, LIT - Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action. 

https://passionstruck.com/passion-struck-book/ - Order a copy of my new book, "Passion Struck: Twelve Powerful Principles to Unlock Your Purpose and Ignite Your Most Intentional Life," today! Picked by the Next Big Idea Club as a must-read for 2024.In this episode of Passion Struck, host John R. Miles sits down with Dr. Jeff Karp, a distinguished figure in bio-inspired engineering and a professor at Harvard Medical School and MIT. In this episode, Dr. Karp delves into the core principles of his latest book, "LIT: Life Ignition Tools: Use Nature's Playbook to Energize Your Brain, Spark Ideas, and Ignite Action." Dr. Karp's insights on activation energy, neurodiversity, and the power of asking the right questions provide valuable guidance on igniting the spark within us and leading a more intentional and fulfilling life.Full show notes and resources can be found here: https://passionstruck.com/dr-jeff-karp-on-cultivating-a-lit-state-of-mind/In this episode, you will learn:Activation Energy: Dr. Karp explains activation energy using a chemistry analogy, emphasizing the importance of putting energy into a system to initiate a reaction.Neurodiversity: Dr. Karp discusses the beauty of neurodiversity, highlighting how different perspectives and ways of thinking can lead to valuable insights and learning opportunities.Importance of Questions: Dr. Karp emphasizes the vitality of inquiry and the significance of asking high-value questions to unlock curiosity and drive progress.Live for the Questions: Dr. Karp shares a personal story about learning to ask high-value questions by observing patterns in seminar questions and applying a systematic approach to improve his questioning skills.All things Dr. Jeff Karp: https://www.karplab.net/team/jeff-karpSponsorsBrought to you by Indeed. Head to https://www.indeed.com/passionstruck, where you can receive a $75 credit to attract, interview, and hire in one place.Brought to you by Nom Nom: Go Right Now for 50% off your no-risk two week trial at https://trynom.com/passionstruck.Brought to you by Cozy Earth. Cozy Earth provided an exclusive offer for my listeners. 35% off site-wide when you use the code “PASSIONSTRUCK” at https://cozyearth.com/This episode is brought to you by BetterHelp. Give online therapy a try at https://www.betterhelp.com/PASSIONSTRUCK, and get on your way to being your best self.This episode is brought to you By Constant Contact:  Helping the Small Stand Tall. Just go to Constant Contact dot com right now. So get going, and start GROWING your business today with a free trial at Constant Contact dot com.--► For information about advertisers and promo codes, go to:https://passionstruck.com/deals/Catch More of Passion StruckMy solo episode on Why We All Crave To Matter: Exploring The Power Of Mattering: https://passionstruck.com/exploring-the-power-of-matteringWatch my interview with Robert Waldinger On What Are The Keys To Living A Good Life.Watch my interview with Dr. Michael Lewis On Breakthrough Integrative Medicine Approach For Traumatic Brain InjuryCan't miss my episode with Dr. Mark Hyman On How Personalized Medicine Is Revolutionizing HealthcareListen to my interview with Dr. Scott Sherr On How To Improve Brain Function With Methylene Blue And NootropicsCatch my episode with Jim Kwik On Unlocking Your Best Brain And Brightest Future.Like this show? Please leave us a review here-- even one sentence helps! Consider including your Twitter or Instagram handle so we can thank you personally!How to Connect with JohnConnect with John on Twitter at @John_RMiles and on Instagram at @john_R_Miles.Subscribe to our main YouTube Channel Here: https://www.youtube.com/c/JohnRMilesSubscribe to our YouTube Clips Channel: https://www.youtube.com/@passionstruckclipsWant to uncover your profound sense of Mattering? I provide my master class with five simple steps to achieving it.Want to hear my best interviews? Check out my starter packs on intentional behavior change, women at the top of their game, longevity and well-being, and overcoming adversity.Learn more about John: https://johnrmiles.com/

Join me as I continue my fascinating dialogue with Jeff Wetzler, author of "Ask," where we unravel the art of inquiry and its potential to unlock wisdom from those around us. We venture into the 'ask approach,' a transformative five-step journey that begins with choosing curiosity. Listen in as we tackle the complexities of media influence and the critical need for quality questioning amidst a climate of sensationalism and partisanship. We'll explore how CEOs create spaces for honest dialogue within their companies, and I'll share personal anecdotes that illuminate the power of adjusting our approaches for more meaningful exchanges. You'll learn strategies for full-spectrum listening that goes beyond words to emotions and actions, setting the stage for profound connection and understanding. The conversation culminates with the 'sift and turn' method for feedback reflection, a process for discerning valuable insights from critique. We'll discuss how results and relationships are the dual pillars of success in both personal and professional realms, and Jeff's expertise shines as we pinpoint the moments when everything aligns, bringing us to those 'exactly moments' where true progress is made. Don't miss out on these invaluable insights that will surely enhance your communication skills and enrich your life. Buy Jeff's book. Follow Jeff on LinkedIn, and X. Join my weekly newsletter. Learn more about my books and courses. Join The Essentialism Academy. Follow me on LinkedIn, Instagram, X, Facebook, and YouTube. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jeff is a Professor at Harvard Medical School and MIT and author of the new book LIT. In this episode, he discusses how we can spark ideas, ignite action, and learn from nature.   Care to play a game with the youniverse? Ask the universe the episode you would most benefit from hearing next and click positivehead.com/game.  Download The Golden Key audio or e-book at GoldenKey.Gift with the Code: POSITIVEHEAD

Do you feel like you're not reaching your full potential? So many men know there is more to life and more to what they're capable of doing. But, at times, we all fail to realize what we know, deep down within us, that we can accomplish. So, what then do we lack if we know what we want but fail to obtain it. I believe the answer is systems to ensure that we're on the path to success. My guest believes that as well. His name is Jeff Karp. He is a biomedical engineer at Harvard Medical School and MIT and the author of his latest book, LIT (Life Ignition Tools). Today we talk about the power of questions and curiosity, what true diversity looks like and how only it can lead to strength, how neurodiversity and plasticity will change the way we look at problems and solutions, the power of pressing pause, and finding new ways to develop conscious thinking. SHOW HIGHLIGHTS (0:00) Episode intro (8:30) How neurodiversity and plasticity will change the way we look at problems and solutions (11:32) The power of questions and curiosity (14:25) Tapping into your flow state (21:31) The power of pressing pause (32:45) You don't need to solve all problems, just the ones you're bothered by (36:08) Stay proximate to the problem (50:00) What true diversity looks like and it can only lead to strength (54:15) Finding new ways to develop conscious thinking Order of Man Merchandise. Pick yours up today! Get your signed copy of Ryan's latest book, The Masculinity Manifesto Want maximum health, wealth, relationships, and abundance in your life? Sign up for our free course, 30 Days to Battle Ready Download the NEW Order of Man Twelve-Week Battle Planner App and maximize your week.

Have you ever noticed those water towers, scattered across the horizon, and thought "Hmm... I wonder how those work?" Well, there's actually lot to learn from them about how to manage your life as a creative pro.In this episode, we explore the idea of managing energy instead of time in our creative process. Our guests, Lisa Congdon, Brian Johnson (author of Areté), Tony Schwartz (author of Be Excellent At Anything), and Jeff Karp (author of LIT), share their insights on the importance of understanding the creative process as a journey with highs and lows. We explore the link between physical and creative energy, emphasizing the significance of managing energy effectively to achieve peak performance in our work.The episode covers essential strategies for managing energy, including the concept of activation energy, the impact of deep work and intermittent renewal, and the importance of prioritizing tasks based on their energy requirements. It also delves into the power of micro-progress, the negative effects of multitasking, and the value of starting each day with the most important task.Key learnings:1. Managing energy is crucial for achieving peak performance in creative work.2. Prioritizing the most important task at the start of the day can significantly impact productivity.3. Working in increments and avoiding multitasking can lead to higher quality work.4. Small victories and low activation energy goals can contribute to overall energy management and motivation.5. Recognizing the link between physical and creative energy is essential for sustained optimal performance.Get full interviews and daily content in the Daily Creative app at DailyCreative.appMentioned in this episode:NEW BOOK! The Brave Habit is available nowRise to important moments in your life and work by developing the habit of bravery. Available in paperback, ebook, or audiobook wherever books are sold. Learn more

In this live taping of Lab Rats to Unicorns, John Flavin and Jeff Karp discuss the challenges and triumphs of bringing lab research to market, the evolving landscape of biotech startups, and the importance of interdisciplinary collaboration in driving scientific breakthroughs. Dr. Jeff Karp is a renowned figure in the biotechnology sector, known for his groundbreaking work and innovative approaches in the field. With a career that bridges both academic research and industry application, Dr. Karp has been at the forefront of developing cutting-edge biotechnological solutions to some of healthcare's most pressing challenges. Jeff is the Distinguished Chair at Brigham and Women's Hospital, a Professor at Harvard Medical School, Affiliate Faculty at MIT & The Broad Institute, and Principal Faculty at the Harvard Stem Cell Institute His expertise spans a range of areas, including drug delivery systems, regenerative medicine, and tissue engineering. Dr. Karp's work is characterized by a commitment to translational research, aiming to bring laboratory discoveries into practical medical use. His leadership in various biotech initiatives and collaborations has been instrumental in driving forward the boundaries of medical science and patient care. Jeff has won numerous awards around his innovations and entrepreneurial successes.

In this fascinating discussion, Dr. Jeff Karp, a top biomedical innovator pulls back the curtain on the difficult journey medical breakthroughs must take to actually help patients. From navigating financial hurdles and clinical trial complexities to manufacturing challenges, hear the surprising barriers promising cures often face on their journey to your local pharmacy.   You'll also get an inside look at how real solutions are being developed. Discover how a nasal spray was created to potentially block COVID transmission and learn about groundbreaking "medical superglue" aiming to revolutionize heart repairs.   If you've ever wondered what really happens after exciting discoveries are made in white coats and petri dishes, don't miss this amazing conversation revealing the untold story of how cutting-edge science becomes accessible healthcare.   Highlights: 00:00 Intro 00:45 Who is Dr. Jeff Karp? 02:30 Complexity of finding and commercializing new solutions 06:42 Dr. Karp's new book overview 08:30 Indigenous holistic approach to health 09:44 Narrowing of the senses we use to experience the world 11:40 Spartan shield for your nose – Profi Nasal Spray 15:10 Developing glue that can work inside the body

Jeffrey Karp is a photographer based in Minneapolis, Minnesota. Jeff's street photography has a fine art look to it, with a focus on minimalist compositions, straight lines and heavy black shadows.  In 2020, he co-founded the photography collective Stolen Echoes and has previously worked as a curator for the Street Finder Instagram hub. In 2022, he started and released a monthly email newsletter titled A Twenty Percent Creative Jeff's photography has been featured by Apple - no less! - as well as Adobe Lightroom, FUJILOVE and having been published in a number of publications such as F8 and Fisheye magazine.  Follow Jeff:WebsiteInstagram

Tissium's co-founder and Chief Innovation Officer, Maria Pereira chronicles her journey into medtech and how a plan to mend heart tissue led to the formation of a company. Pereira co-invented Tissium's technology while she was a PhD student at Prof. Jeff Karp's Laboratories. She has been recognized for her research by MIT Tech Review's “35 Innovators Under 35” in 2014, as well as Forbes in its “30 under 30” selection in healthcare in 2015.

In this episode, Ebony and Jyo chat with Jeff Karp, who is not only an incredible street photographer but also a pediatric dentist and a university professor! We chat with him about finding art in your daily life, getting inspired, his photography journey and so much more! We are fascinated by what Jeff creates and how he sees the world around him and we know you will too. About Jeff - https://www.callmeartistretreat.com/jeff-karpHis work - https://www.jeffreymkarp.comCheckout Call Me Artist here - https://www.callmeartistretreat.com/

Mark Pincus was at the forefront of mobile technology when it was just being born. He is a recovering venture capitalist who co-founded his first company with Sunil Paul in 1995. FreeLoader was at the forefront of giving people the news through push technology, just as the IETF was in the process of ratifying HTTP2. He sold that for $38 million only to watch it get destroyed. But he did invest in a startup that one of the interns founded when he gave Sean Parker $100,000 to help found Napster.  Pincus then started Support.com, which went public in 2000. Then Tribe.net, which Cisco acquired. As a former user, it was fun while it lasted. Along the way, Pincus teamed up with Reid Hoffman, former PayPal executive and founder of LinkedIn and bought the Six Degrees patent that basically covered all social networking. Along the way, he invested in Friendster, Buddy Media, Brightmail, JD.com, Facebook, Snapchat, and Twitter.  Investing in all those social media properties gave him a pretty good insight into what trends were on the way. Web 2.0 was on the rise and social networks were spreading fast. As they spread, each attempted to become a platform by opening APIs for third-party developers. This led to an opening to create a new company that could build software that sat on top of these social media companies. Meanwhile, the gaming industry was in a transition from desktop and console games to hyper-casual games that are played on mobile devices. So Pincus recruited conspirators to start yet another company and with Michael Luxton, Andrew Trader, Eric Schiermeyer, Steve Schoettler, and Justin Waldron, Zinga was born in 2007. Actually Zinga is the dog. The company Zynga was born in 2007. Facebook was only three years old at the time, but was already at 14 million users to start 2007. That's when they opened up APIs for integration with third party products through FBML, or Facebook Markup Language. They would have 100 million within a year. Given his track record selling companies and picking winners, Zynga easily raised $29 million to start what amounts to a social game studio. They make games that people access through social networks. Luxton, Schiermeyer, and Waldron created the first game, Zynga Poker in 2007. It was a simple enough Texas hold 'em poker game but rose to include tens of millions of players at its height, raking in millions in revenue.  They'd proven the thesis. Social networks, especially Facebook, were growing.. The iPhone came out in 2007. That only hardened their resolve. They sold poker chips in 2008. Then came FarmVille. FarmVille was launched in 2009 and an instant hit. The game went viral and had a million daily users in a week. It was originally written in flash and later ported to iPhones and other mobile platforms. It's now been installed over 700 million times and ran until 2020, when Flash support was dropped by Facebook. FarmVille was free-to-play and simple. It had elements of a 4x game like Civilization, but was co-op, meaning players didn't exterminate one another but instead earned points and thus rankings. In fact, players could help speed up tasks for one another. Players began with a farm - an empty plot of land. They earned experience points by doing routine tasks. Things like growing crops, upgrading items, plowing more and more land. Players took their crops to the market and sold them for coins. Coins could also be bought. If a player didn't harvest their crops when they were mature, the crops would die. Thus, they had players coming back again and again. Push notifications helped remind people about the state of their farm. Or the news in FreeLoader-speak.   Some players became what we called dolphins, or players that spent about what they would on a usual game. Maybe $10 to $30. Others spent thousands, which we referred to as whales. They became the top game on Facebook and the top earner. They launched sequels as well, with FarmVille 2 and FarmVille 3.  They bought Challenge Games in 2010, which was founded by Andrew Busy to develop casual games a well. They bought 14 more companies. They grew to 750 employees. They opened offices in Bangalore, India and Ireland. They experimented with other platforms, like Microsoft's MSN gaming environment and Google TV. They released CastleVille. And they went public towards the end of 2011. It was a whirlwind ride, and just really getting started. They released cute FarmVille toys.  They also released Project Z, Mafia Wars, Hanging with Friends, Adventure World, and Hidden Chronicles. And along the way they became a considerable advertising customer for Facebook, with ads showing up for Mafia Wars and Project Z constantly. Not only that, but their ads flooded other mobile ad networks, as The Sims Social and other games caught on and stole eyeballs. And players were rewarded for spamming the walls of other players, which helped to increase the viral nature of the early Facebook games. Pincus and the team built a successful, vibrant company. They brought in Jeff Karp and launched Pioneer Trail. Then another smash hit, Words with Friends. They bought Newtoy for $53.3 million to get it, after Paul and David Bettner who wrote a game called Chess with Friends a few years earlier. But revenues dropped as the Facebook ride they'd been on began to transition from people gaming in a web browser to mobile devices. All this growth and the company was ready for the next phase. In 2013, Zynga hired Donald Mattrick to be the CEO and Pincus moved to the role of Chief Product Officer. The brought in Alex Garden, the General Manager for Xbox Music , Video, and Reading, who had founded the Homeward creator Relic Entertainment back in the 1990s. The new management didn't fix the decline. The old games continued to lose market share and Pincus came back to run the company as CEO and cut the staff by 18 percent. In 2015 they brought in Frank Gibeau to the board and by 2016 moved him to  CEO of the company. One challenge with the move to mobile was who got the processing payments. Microtransactions had gone through Facebook for years. They moved to Stripe in 2020. They acquired Gram Games, to get Merge Dragons! They bought Small Giant Games to get Empires & Puzzles. They bought Peak Games to get Toon Blast and Toy Blast. They picked up Rollic to get a boatload of actions and puzzle games. They bought Golf Rival by acquiring StarLark. And as of the time of this writing they have nearly 200 million players actively logging into their games. There are a few things to take from the story of Zynga. One is that a free game doesn't put $2.8 billion in revenues on the board, which is what they made in 2021. Advertising amounts for just north of a half billion, but the rest comes from in app purchases. The next is that the transition from owner-operators is hard. Pincus and the founding team had a great vision. They executed and were rewarded by taking the company to a gangbuster IPO. The market changed and it took a couple of pivots to get there. That led to a couple of management shakeups and a transition to more of a portfolio mindset with the fleet of games they own. Another lesson is that larger development organizations don't necessarily get more done. That's why Zynga has had to acquire companies to get hits since around the time that they bought Words with Friends.  Finally, when a company goes public the team gets distracted. Not only is going through an IPO expensive and the ensuing financial reporting requirements a hassle to deal with, but it's distracting. Employees look at stock prices during the day. Higher ranking employees have to hire a team of accountants to shuffle their money around in order to take advantage of tax loopholes. Growth leads to political infighting and power grabbing. There are also regulatory requirements with how we manage our code and technology that slow down innovation. But it all makes us better run and a safer partner eventually. All companies go through this. Those who navigate towards a steady state fastest have the best chance of surviving one more lesson: when the first movers prove a monetization thesis the ocean will get red fast. Zynga became the top mobile development company again after weathering the storm and making a few solid acquisitions. But as Bill Gates pointed out in the 1980s, gaming is a fickle business. So Zynga agreed to be acquired for $12.7 billion in 2022 by Take-Two Interactive, who now owns the Civilization, Grand Theft Auto, Borderlands, WWE, Red Dead, Max Payne, NBA 2K, PGA 2K, Bioshock, Duke Nukem, Rainbow Six: Rogue Spear, Battleship, Centipede, and the list goes on and on. They've been running a portfolio for a long time. Pincus took away nearly $200 million in the deal and about $350 million in Take-Two equity. Ads and loot boxes can be big business. Meanwhile, Pincus and Hoffman from LinkedIn work well together, apparently. They built Reinvent Capital, an investment firm that shows that venture capital has quite a high recidivism rate. They had a number of successful investments and SPACs.  Zynga was much more. They exploited Facebook to shoot up to hundreds of millions in revenue. That was revenue Facebook then decided they should have a piece of in 2011, which cut those Zynga revenues in half over time. This is an important lesson any time a huge percentage of revenue is dependent on another party who can change the game (no pun intended) at any time. Diversify. 

News Reversing hearing loss with regenerative therapy | MIT News (01:28) Approximately 15% of American adults (37.5 million) aged 18 and over report some trouble hearing. The biotechnology company Frequency Therapeutics is seeking to reverse hearing loss — not with hearing aids or implants, but with a new kind of regenerative therapy.Using small molecules to program progenitor cells – a descendant of stem cells in the inner ear — to create the tiny hair cells that allow us to hear. In more detail, progenitor cells reside in the inner ear and generate hair cells when humans are in utero, but they become dormant before birth and never again turn into more specialized cells such as the hair cells of the cochlea. Frequency's drug candidate is designed to be injected into the ear to regenerate these cells within the cochlea.already improved people's hearing as measured by tests of speech perception The company has dosed more than 200 patients to date and has seen clinically meaningful improvements in speech perception in three separate clinical studies. MIT Institute Professor Robert Langer talked on the study results: “Some of these people [in the trials] couldn't hear for 30 years, and for the first time they said they could go into a crowded restaurant and hear what their children were saying … It's so meaningful to them. Obviously more needs to be done, but just the fact that you can help a small group of people is really impressive to me.” One company founder, Jeff Karp believes Frequency's work will advance researchers' ability to manipulate progenitor cells and lead to new treatments down the line.“I wouldn't be surprised if in 10 or 15 years, because of the resources being put into this space and the incredible science being done, we can get to the point where [reversing hearing loss] would be similar to Lasik surgery, where you're in and out in an hour or two and you can completely restore your vision … I think we'll see the same thing for hearing loss.” Engineered bacteria could help protect “good” gut microbes from antibiotics | Big Think (07:01) Following antibiotic treatment, some patients are at risk of developing inflammation or opportunistic infections.Antibiotics are indiscriminate with their attacks on bacteria, so they end up harming the beneficial microbes that live in the human gut. In an effort to reduce those risks, MIT engineers have developed a new way to help protect the natural flora of the human digestive tract. Beta-lactams make up about 60 percent of the antibiotics prescribed in the United States. Took a bacteria (Lactococcus lactis) safe for humans, and engineered it to produce enzymes that break down a class of antibiotics called beta-lactams (i.e. ampicillin, amoxicillin, etc.) It protects the microbiota in the gut but allows the levels of antibiotics circulating in the bloodstream to remain high. After the bacteria's job is finished, the engineered bacteria are excreted through the digestive tract. Andres Cubillos-Ruiz PhD talks on the effects of medication and diet can have on the gut microbiome:“Throughout your life, these gut microbes assemble into a highly diverse community that accomplishes important functions in your body … The problem comes when interventions such as medications or particular kinds of diets affect the composition of the microbiota and create an altered state, called dysbiosis. Some microbial groups disappear, and the metabolic activity of others increases. This unbalance can lead to various health issues.” To test their approach, the researchers gave the mice two oral doses of the engineered bacteria for every injection of ampicillin.In those mice, the researchers found that the amount of ampicillin circulating the bloodstream was as high as that in mice who did not receive the engineered bacteria. In the gut, mice that received engineered bacteria maintained a much higher level of microbial diversity compared to mice that received only antibiotics.  The researchers now plan to begin developing a version of the treatment that could be tested in people at high risk of developing acute diseases that stem from antibiotic-induced gut dysbiosis.   Wireless camera tool could make intubation safer and easier | Futurity  (12:40) Intubation is the process of inserting a tube into the mouth or nose and then into the airway to help move air in and out of the lungs. used to support breathing during surgery or an emergency A team of Rice University bioengineering students designed a new handheld, 3D-printed device with a miniature wireless camera, which could make intubation easier and safer. Kenneth Hiller, an anesthesiologist in private practice, who initiated the project, discusses the current practice:“Current state-of-the-art devices have limitations … Placing an endotracheal tube can be challenging in a significant number of patients' airways. For years, I've mulled over what I'd like in a device that can simplify the process and improve patient safety.” Hiller, who approached the team of engineers at the university, knew what he wanted to build but didn't know how to build it himself. Had a model with popsicle sticks and metal. One of the engineering students, Victoria Kong, explains the two different scope types:“There are two main types of laryngoscopes: with straight blades and with curved blades, and all of the video laryngoscopes on the market are in the curved blade format. While that's great for compressing the tongue to get it out of the way, it has a very high displacement volume. It takes up a lot of room in the mouth …  The straight blade gives you a more direct line of sight. We wanted to combine the stabilization afforded by curved blades and a straight-blade profile, and we did that by tapering our blade.” The project is looking at a wireless camera, since current market scopes have wired cameras that makes it bulky and reduces the amount of people in the room at one time. A wireless camera will allow doctors to view it on a smaller screen (i.e. tablet) while not being in the room during the process. “Having the video accessible on a tablet means a doctor in another room can watch and give feedback about technique to the airway manager performing the actual procedure,” according to Rebecca Franklin, who was a part of the design team. The students say they anticipate future refinements to include stainless steel construction for durability. They also see uses for the device beyond the clinic.   A massive "space cannon" can shoot payloads into space at hypersonic speeds  | Interesting Engineering (16:31)  An alternative rocket launch firm called Green Launch is developing a system to send small launch vehicles into space using a massive gas cannon.  With a 54-foot (16.5-meter) launch tube, the company was able to fire a payload into the stratosphere at a velocity exceeding Mach 3. A little taller than the length of a Semi-Truck trailer.  If the company is able to scale the system, the explosive method has the potential to massively reduce the cost and carbon footprint of small satellite launches.BIG IF! The concept of an artillery gun used as a low-cost method for sending payloads into space dates back to the U.S. Army's High Altitude Research Project (HARP) of the 1960s.HARP set a record in 1966 by firing a projectile above the 100-kilometer Kármán Line —  considered by many to be the line between Earth and space. Then HARP transitioned to the SHARP program (S = super) developed the hydrogen impulse launcher, which features a long thin barrel filled with hydrogen mixed with helium and oxygen. Sounds familiar!The SHARP program's 400-foot (122-m) impulse launcher broke records in the 90s by launching payloads at speeds of up to Mach 9. Now, Green Launch wants to leverage that technology to disrupt the booming small satellite launch sector.Green Launch says its "proof of concept" impulse launch will allow it to attempt to send a projectile past the Kármán Line later this year.  The company believes its method could also eventually be scaled to reach hypersonic speeds as high as Mach 20.  Green Launch CTO Dr. John Hunter talks about the process:“The trick is using a light gas like hydrogen, which has a very low molecular weight … You can get very high velocities that aren't possible with railguns or other systems. This has zero carbon emission and will allow us to revolutionize access to space and open the solar system to manned exploration." Green Launch will eventually have to build a launch vehicle that fires a small amount of propellant for course correction and placement once in orbit.  If its upcoming launch tests prove successful, Green Launch says it first aims to deploy its system to send atmospheric sampling devices to space to collect data for climatologists.  A new heat engine with no moving parts is as efficient as a steam turbine | MIT News  (22:54) Engineers at MIT and the National Renewable Energy Laboratory (NREL) have designed a heat engine with no moving parts. Converts heat to electricity with over 40 percent efficiency — a performance better than that of traditional steam turbines. On average, steam turbines reliably convert about 35 percent of a heat source into electricity, with about 60 percent representing the highest efficiency of any heat engine to date.  The heat engine is a thermophotovoltaic (TPV) cell, similar to a solar panel's photovoltaic cells, that passively captures high-energy photons from a white-hot heat source and converts them into electricity.Generates electricity from a heat source of between 1,900 to 2,400 degrees Celsius, or up to about 4,300 degrees Fahrenheit. The researchers plan to incorporate the TPV cell into a grid-scale thermal battery. Would absorb excess energy from renewable sources such as the sun and store that energy in heavily insulated banks of hot graphite. When the energy is needed, such as on overcast days, TPV cells would convert the heat into electricity, and dispatch the energy to a power grid. As of right now, the new TPV cell, the team has now successfully demonstrated the main parts of the system in separate, small-scale experiments. They are working to integrate the parts to demonstrate a fully operational system.  They have hopes to scale up the system to replace fossil-fuel-driven power plants and enable a fully decarbonized power grid, supplied entirely by renewable energy. For a grid-scale thermal battery system, The TPV cells would have to scale up to about 10,000 square feet (about a quarter of a football field). Operate in climate-controlled warehouses to draw power from huge banks of stored solar energy. Robert N. Noyce Career, professor at MIT, states: “Thermophotovoltaic cells were the last key step toward demonstrating that thermal batteries are a viable concept … This is an absolutely critical step on the path to proliferate renewable energy and get to a fully decarbonized grid.”  

Dr. Jen Welter, Coach Kevin Ward, and Dr. Jeff Karp are the people we need to listen to for advice to build the best team of people possible in all walks of life. Dr. Jeff Karp says, “When you take someone who is outside the discipline, they start asking these basic questions that can actually break down those dogmas. And then you start questioning, you know, how the entire field was evolved. You know, like there's like this kind of framework and you start breaking down that framework and you realize that there's completely new ways of thinking that could be helpful. So I think just as a general kind of principle in life, it's, you know, surrounding yourself with people who have expertise and skills that you don't have.” In this episode you'll learn: - Using diversity as a strength from Dr. Jen Welter - Defining your culture with Coach Kevin Ward. How to maintain a team that wants to work and serve themselves - Why Dr. Jeff Karp has multiple people from different backgrounds to bring a deeper understanding to all problems   If you want to watch the full episodes, The first female coach in the NFL - Dr. Jen Welter / Interviewed by Joe De Sena https://youtu.be/1FYCWKNFfQY 271: Kevin Ward | How West Point Wrestling Builds Team Culture https://youtu.be/Qkvxr3UFWt0 Dr. Jeff Karp | Problem-Solving Skills from the Bio-Tech Industry https://youtu.be/RoUx-IYLw0c   SPONSOR This episode of Power Up! is brought to you by Trifecta. Unbox your best self with the food, coaching, and community support you need to reach your goals. Trifecta delivers delicious, macro-balanced meals directly to your door. Let Trifecta handle meal prep and take 40% off your first order using code SPARTAN at checkout.   SUBSCRIBE: Apple Podcasts: http://bit.ly/SpartanUpShow YouTube: http://bit.ly/SpartanUpYT Spotify: https://open.spotify.com/show/1pYBkk1T684YQg7CmoaAZt FOLLOW SPARTAN UP: Spartan Up on Instagram https://www.instagram.com/spartanuppodcast/ Spartan Up on Twitter https://twitter.com/SpartanUpPod CREDITS: Producer: Lake Watters Hosts: Johnny Waite, Joe De Sena Co-Hosts: Sefra Alexandra, Col. Nye Sr Producer: Marion Abrams © 2022 Spartan

We live in a world of constraints - some are physical, some cultural but they are always personal. These mindsets limit our human potential to achieve great things in life and hinder experiences that not only enrich ourselves but also benefit society at large. INSEAD celebrates women who have dared to push beyond their own limits and conquer obstacles in their lives to create positive change. Welcome to another episode of In The Know where in today's episode we celebrate the incredible feats of our five guests with a digital roundtable discussion. Our Guests Tade Fayomi – MBA'19J Finance & Strategy Consultant @ BCG Straight from university, Tade joined Goldman Sachs. She worked there for eight years and rose through the ranks from Analyst to Associate, and Vice President while being moved to work in the organisation's London, New York, Singapore and Dubai offices. Tade went on to complete her MBA and work with the Africa Finance Corporation in 2018 before landing her current role as a Finance & Strategy Consultant at BCG. Isavella Vitou – EMC'21 Chief Strategy and Transformation Officer @ Allianz Greece Isavella joined Allianz in May 2021 as the Chief Strategy & Transformation Officer. Before joining Allianz, Isavella worked for Egon Zehnder and gained valuable experience in C-level executive search and assessment. In her mandate, she supported the growth of the business and successfully managed rapport with both candidates and clients. Before that, Isavella worked for Eurobank, Ernst & Young and at the Ministry of Tourism acting as a Consultant to the President of the Greek National Tourism Organization at the Ministry of Tourism. Sofia Arhall Bergendorff – MBA'03D Director, Platforms and Partnerships, Northern Europe @ Google, Denmark Sofia is the Director of Partnerships in Northern Europe for Google, managing the relationship between Google and publishers when it comes to ad markets. Before that role, Sofia spent seven years in a Google strategy operations team in the Nordics and globally with the publisher business.  Before Google Sofia spent many years in management consulting and working with start-ups. Maria Pereira – MBA'18D Chief Innovation Officer @ TISSIUM Maria Pereira leads the Innovation Hub at TISSIUM. She co-invented the development of Tissium's range of biomorphic programmable polymers technology while a PhD student at Prof. Jeff Karp's Laboratories. She has been recognized for her research by MIT Tech Review's “35 Innovators Under 35” in 2014, as well as Forbes in its “30 under 30” selection in Healthcare in 2015. Maria holds a PhD in Bioengineering from the MIT-Portugal program and an MBA from INSEAD. Chiara Lepora – EMBA'18Dec Head of the Manson Unit / Deputy Medical Director of OCA @ Médecins Sans Frontières (MSF) Chiara trains people in the design, planning, implementation and management of humanitarian medical interventions; security management; networking and negotiations; project management, especially in emergencies. Chiara also provides consultation services in the topics of ethics of medicine in non-ideal circumstances; ethics of research; ethics of public health; bioethics; global health; allocation of scarce resources. References https://herminiaibarra.com/books/ https://hbr.org/2020/12/how-to-lead-when-your-team-is-exhausted-and-you-are-too https://www.ted.com/talks/frances_frei_how_to_build_and_rebuild_trust?language=en Time Stamp 01:25 - Guest background and career aspirations 08:31 - What do you consider your greatest achievement? 17:10 - What does limitless mean to you? 22:18 - Can you describe some of the limitations you have faced and the tipping point that motivated you to take action against those limitations? 32:27 - What are some of the most meaningful skills young women can learn today to help them achieve their ambitions? 39:15 - What is one tip you can offer to help build a more inclusive and diverse workforce? 39:49 - What one piece of advice would you give our listeners to help break through their barriers and become limitless? 40:38 - What insights can you offer for women looking to advance their careers? 40:55 - Why are you optimistic about the future of women in business? 42:00 - Who do you look to for inspiration and can you recommend any sources of inspiration our listeners can follow, read about or watch?

Takeaways from today's episode: Simple science is beautiful, but you must be open and be quick on your, learn on the job and do NOT minimise the advantage of soft skills.There is no curriculum that will teach you all the skills you will need to succeed as an independent researcher but you can seek out good mentorship, engage with the public, pioneer flat leadership systems, and where you can, employ virtual systems/communications to increase visibility and learning.There is room to analyse a problem in smaller bitesize chunks using available resourcesRemember a little can go a long way to prioritise peoples health and well-being  Focus on scalable ways to address regional problems - “Regional focus with international footprint” and remember that the mission is to improve health for everyone. Resources:Fredros’ TED talk on developing creative innovative solutions for malaria prevention in rural Tanzania :https://www.ted.com/talks/fredros_okumu_why_i_study_the_most_dangerous_animal_on_earth_mosquitoesBill Gates on supporting Fredros’ work: https://www.linkedin.com/posts/williamhgates_would-you-put-your-arm-in-a-cage-with-500-activity-6703376045862600704-WFq2Ubuntu philosophy: https://en.wikipedia.org/wiki/Ubuntu_philosophyRedzone podcast interviewing Dr. Jeff Karp on “Simplicity is the ultimate sophistication” https://www.youtube.com/watch?v=B01FSkPgS2k Guest information:Dr. Fredros Okumu is Director of Science at Ifakara Health Institute in Tanzania. He is a mosquito biologist and public health expert working on sustainable approaches for controlling vector-borne diseases. He is also passionate about improving ecosystems for young researchers in Africa.  @Fredros_Inc (on twitter) blogs here [malariaworld.org], and has ~100 scientific publications archived here[scholar.google.co.uk] & here [ncbi.nlm.nih.gov].Prof. Marco Mello is a Brazilian biologist with a PhD. in ecology, alumnus of the Alexander von Humboldt-Stiftung. He worked as an associate researcher at Ulm University, Germany, and currently works as an associate professor at the University of São Paulo, Brazil. His research focuses on ecological synthesis, mainly about species interactions. Connect with Marco on twitter: @marcoarmello and his website: https://marcomellolab.wordpress.com AcknowledgementsEditing by Mariana Vaz, https://www.marianacpvaz.com/Research: Alice MatimbaProducers: Alice Matimba (Senior Producer), Isabela Malta (Producer), Christine Boinett (Creator and Executive producer), Emmanuela Oppong (Producer)Host: Alice MatimbaMedia and Marketing: Catherine HolmesMusic: https://freesound.org/s/477388/ Sponsors:Wellcome Genome Campus Advanced Courses and Scientific ConferencesWellcome Sanger InstituteSocial Entrepreneurship to Spur Health

Medtech People: In this week’s DeviceTalks Weekly Podcast, we’ll talk about overcoming unfairness and inequity. In our keynote interview, Boston Scientific’s Camille Chang Gilmore, vice president, human resources, global chief diversity officer, and Michael Jaff, MD, CMO of its peripheral vascular group, reintroduce us to the company’s Close the Gap program. Launched in 2006, Close the Gap seeks to address the lack of care being delivered to underserved populations, including people of color and people earning lower incomes. The two Boston Science executives will explain why Close the Gap is more essential than ever, and what we as an industry need to do to bring equality to care. Go to knowyourhealth.com for more information. In our first interview, Jeff Karp, MD, a prolific inventor and entrepreneur, shares his early challenges as a child when a learning difference limited his performance in school. After hearing some stern advice from teachers, Karp identified the problem and explained how overcoming his challenges gave him the ability to see innovative ways to solve problems. Go to devicetalks.com to see the rest of the Device Talks Tuesday interview from Sept. 22. https://www.devicetalks.com/devicetalks-tuesdays-on-demand-sessions/ And, of course, Chris Newmarker, executive editor of MassDevice, runs us through Newmarker’s Newsmakers, the top 5 performing articles on MassDevice. Subjects include Boston Scientific, Farapulse, the FDA, and NanoVibronix. https://www.massdevice.com/the-top-5-massdevice-stories-of-the-week-september-25-2020/ GUESTS:  Camille Chang Gilmore, vice president, human resources and global chief diversity officer, Boston Scientific  Michael Jaff, MD, vice president, CMO, Boston Scientific, peripheral vascular group  Jeff Karp, MD, professor of medicine, Brigham and Women’s Hospital, Harvard Medical School HOSTS  Chris Newmarker, executive editor, life sciences, WTWH Media  Tom Salemi, editorial director, DeviceTalks

Jeff Karp was inspired by porcupine quills to improve surgery. Perry Carver of the Bonnie and Clyde Ambush Museum reveals the tender side of Bonnie and Clyde. Oregon Health and Science University's Vinay Prasad on what happens when doctors realize treatment protocol is ineffective.

Jeff Karp, PhD, Brigham and Women's hospital, discusses the concept of radical simplicity, which he describes as “breaking down the problem into simple terms that you can test.” Karp explains how he used this approach in stem cell therapy research to inform the translational and commercialization process.

Richard Preston teaches us about the would above our heads in tree canopies. Hear the story of how Peter Chan went from engineer to bonsai tree artist. Gabriel Brownstein shares his experience with receiving and promoting open heart surgery. Harvard's Jeff Karp tells us all about a new surgical glue to literally mend broken hearts.

Today I have an amazing guest. His name is Dr. Jeff Karp and he is a Professor of Medicine at Brigham and Women's Hospital in Boston. He is also a Principal Faculty member at the Harvard Stem Cell Institute, and an affiliate faculty member at the Broad Institute and at the Harvard-MIT Division of Health Sciences and Technology. I'm just getting warmed up, wait until you hear the rest of his background. This is a real special guy. He works in the fields of drug delivery, medical devices, stem cell therapeutics, and tissue adhesives. He has published over 125 peer-reviewed papers, with more than 18,500 citations, and has given over 300 invited lectures. He has over 100 issued or pending national and international patents. Several technologies developed in his lab have led to multiple products currently being funded, and he's launched seven companies that have raised over $300 million in funding. These technologies include high-tech skincare, tissue adhesives and 3D-printed biomedical devices, immunomodulation with biologically responsive materials. We talked about small molecule regenerative therapeutics with an initial target of hearing loss and other aging therapies; as well as stem cells, cannabinoid therapeutics, biomedical devices to improve child safety, needles that automatically stop when they reach their target, and a bio-engineered luminal coating for controlled GI targeting. Dr. Karp has received over 50 awards and honors. He has been recognized by Boston Magazine as One of 11 Boston Doctors Making Medical Breakthroughs'; The Boston Business Journal as a Champion in Healthcare Innovation' and by MIT's Technology Review Magazine (TR35) as being one of the Top Innovators In The World - with three members from his laboratory also receiving this award. I spent a lot of time talking to Jeff about how he builds his teams and how he empowers them to take on these projects. What he's done is - he's bridged academia and entrepreneurship and, that's no small feat! I was interested to know - with the co-founding of six companies, how does he get research out into the world to really impact lives? We also talked about mentor development. One of the biggest things that he targets is finding - and building mentors. He is always actively meeting people and he talks about this and why the power of meeting new people every 2 weeks. Another thing we talk about is reducing problems to their essence'. What I love is when I hear scientists talk about how they really place a lot of focus on this radical simplicity' and the art and discipline of reducing problems to their essence so they can solve problems in the useful, practical solutions to real-world problems. This is a really, really fun interview with a world-impact leader in medicine. And bringing cutting edge therapies to market with a team. A team of people really dedicated to changing the world. So, with this, I want to welcome you to my great conversation with Dr. Jeff Karp. Here are some Key Concepts from the Podcast: Simplicity - Why is it so powerful? Complexity vs. Simplicity – The approach you use affects the entire spectrum of a problem or a project beginning with how the problem is defined - and can alter or otherwise impact innovation. Radical Simplicity – the art and discipline of cutting through the complexity and reducing a problem to its essence so you can solve it quickly and it can be practical in the real world. Environment & Culture – How do you create productive impact for elements of culture - within and beyond your team?   Focus on Empowerment - Create an environment where you really appreciate what others are doing, and try not to limit them, but give them the ability to own their projects and empower them, that way people are more likely to go ‘all in’. Alter your instincts and control knee-jerk reactions. Create habits that are not ego-driven but are self-imposed and controlled to serve the purpose that you define for your life. Choose the environment. Create a community where people are all on the same page, are all helping each other and inspiring each other to take risks in a very safe environment. Remove limitations. Have multiple affiliations with different institutions that can provide access to resources, tools and different technologies. Finding and Developing Mentors - Inspire and be inspired. Create simple, meaningful mantras that drive the mission in everything you do. They can help you make decisions of how to spend your time, and how to engage the process to really think through the best way of making decisions, such as Maximize Impact. Inspire and be inspired. Develop a passion about finding a mentor. Look for someone whose hindsight becomes your foresight. Academics to Entrepreneurship – How do you translate academic discoveries into entrepreneurship and develop new companies and quickly turn that into products for patients? Develop and Cultivate Relationships – Commit to meeting someone new every two weeks and continue to cultivate those relationships. Ways to connect with Jeff Karp: LinkedIn    Website   Resources Discussed in this Interview: TEDMED Talk - Insight Outside: Harnessing Nature’s Secrets, February 19, 2015. Jeff Karp, bioengineer and Associate Professor at Brigham and Women’s Hospital, Harvard Medical School, illuminates the art and science of developing medical tools, treatments, and technologies from solutions found in nature. This episode is sponsored by the CIO Innovation Forum, dedicated to Business Digital Leaders who want to be a part of 20% of the planet and help their businesses win with innovation and transformation. I hope you enjoyed this interview with Jeff Karp.   You can go to the show notes to get more information about this interview and what we discussed in this episode. You’ll find the show notes at redzonetech.net/podcasts.  If you are interested in learning more about my company, RedZone Technologies, and our security expertise - in particular related to Cloud and Email Security Kill Chain Strategy, Techniques and Tactics you can email cloudkill@redzonetech.net.   Until next time. I’m signing off. Thank you and have a great day!  Credits Music provided by Ben’s Sound: http://www.bensound.com/ Other Ways to Listen to the Podcast:           iTunes | Libsyn | Soundcloud | RSS | LinkedIn    Leave a Review If you enjoyed this episode, forward it to your LinkedIn community. I also love to hear your comments, please consider leaving a review on iTunes, and for my Droid listeners on Stitcher.  (Click here for instructions on how to leave an iTunes review if you’re doing this for the first time.) About Bill Murphy Bill Murphy is a world renowned IT Security Expert dedicated to your success as an IT business leader. Follow Bill on LinkedIn and Twitter.            

Author Camilla Townsend of Rutgers University tells us the untold story of the Aztecs. Jeff Karp of Harvard Medical School explains a new surgical glue, inspired by nature. Leah Tether of the University of Bristol dives into the legend of King Arthur. Finally we have a visit from Joel Cohen from Rockefeller University and Columbia University in the final installment of our demography series.

Robert Mason of Oregon State University speaks to us on the mating patterns of snakes. Jeff Karp of Harvard Medical School joins us to talk about a new way to close wounds. Professor Karp continues with us later in the hour to discuss an new surgical glue. David Bamberger of Bamberger Ranch Preserve visits with us to tell his story from salesman to rancher. Finally David Potter of the University of Michigan speaks to us about another boarder wall attempt in ancient history.

Invest Alongside Boston's Top Angels: Our Syndicates Seasoned entrepreneur Nancy Briefs on her startup’s daring swing at Type 2 diabetes. AltrixBio is creating a pill that simulates the benefit of the best gastric bypass surgery: remission of diabetes in 80 percent of cases. With co-founders Jeff Karp and Ali Tavakoli, she is re-purposing an existing treatment with a great safety profile to address this daunting problem. Highlights include: Nancy Briefs, co-founded 7 companies and managed, or been on the board of, several others. Together with Dr. Karp and Dr. Tavakoli of Brigham & Women’s Hospital, Nancy co-founded AltrixBio to emulate the results of gastric bypass in a pill. Sal saw Nancy pitch at MIT Angels and Walnut Ventures and was impressed. Ali Tavakoli, M.D. performs the Roux-en-Y procedure which is the gastric bypass operation with the best record of success. Tavakoli and others observed that diabetic patients who experienced the procedure had their Type 2 diabetes go into remission about 80 percent of the time. Seven and a half years ago, upon observing this phenomenon, Dr. Tavakoli approached Jeff Karp, PhD, who trained at MIT’s renowned Langer Lab and works on new ways to deliver treatments to the body, wondering if the results could not be duplicated using a pill. The Roux-en-Y is irreversible and has considerable side effects. Drs. Karp and Tavakoli set to finding a reversible and benign way of mimicking the results of the procedure. Needless to say: Type 2 diabetes is a huge problem that currently eats up one in four dollars spent on healthcare. It a global problem. The team zeroed in on Sucralfate, a drug presently used to treat peptic ulcers that could be modified to produce the desired outcome. Sucralfate is designed to stick only to the ulcers. The modified Sucralfate can be made to adhere to the healthy lining of the digestive tract. The re-engineered drug, called LuCITM, thus, in theory, could be used to coat strategic parts of the intestine to control the uptake of sugar by the patient’s body. LuCITM was tested on mice with encouraging results. There is at present no drug that can cause diabetes to go into remission reliably. The treatment is expected to make part of the digestive system unavailable to nutrients only part of the day. The dosage would permit absorption of critical nutrients the rest of the time. An interesting quality of LuCITM is that it is easy to tune how long it stays in the gut. It is a platform that could be adapted, due to its versatility, to treating other diseases such as NASH or for the targeted delivery of biologics which are highly perishable in the body. Sal loves platforms. SQZ Biotech, Savran tech etc. Nancy says: it gives you more shots on goal. Plus: Sucralfate has a 30-year safety record, which could simplify the approval process. It has an expedited FDA approval path, given the history. It’s possible there could be a signal that it works in humans with the investment of five to seven million dollars. Sal talks about portfolio company SQZ Biotech. Nancy explains how an angel can make money investing in an early stage company. Hint: value creation needs to outpace fundraising by a lot. Nancy Briefs mentions the acquisition of Tilos Therapeutics by Meck for $773 million as an example of the type of exit possible. Silicon Valley Bank study reveals that 80% of companies are acquired at Phase II trials. She believes AltrixBio could be through Phase II trials in four years. Repurposing a drug such as Sucralfate that has a 30-year record of safety with the FDA can greatly shorten and the time to approval and reduce the cost from hundreds of millions to tens of millions The FDA has the files from the five generic suppliers of Sucralfate that show no heart risk, no cancer risk etc. The near-term inflection points for AltrixBio is (1) moving the compounding of the drug from the lab to an outside supplier, Catalant, and (2) once there is usable formulation of the drug AltrixBio will have a “pre-IND” meeting with the FDA to get initial guidelines for the approval process such as how many subjects will be required and what they acceptable endpoints might be in the first clinical trials. This information is expected to de-risk the investment substantially and to allow a sharper focus on how much money will be needed to fund clinical trials through Phase II. At the end of 2020, AltrixBio will already be at first-in-human trials and to have enrolled 15 to 20 patients. Nancy recalls pivotal times in her career. As a young sales rep for Pfizer she was impressed by a heart valve surgery she witnessed and realized at that moment that she wanted to spend her life in healthcare. Nancy’s decision to work in healthcare was reinforced by getting her MBA. Nancy recollects the various positions she had and what she got out of it. Nancy’s father ran a Pillsbury plant. Her mother was a small banker. Nancy discovered leadership early. She was student body president at her high school. Innovation = Invention X Commercialization, Ed Roberts from MIT/ Sloan Nancy says that in order to have a business in biotech you need a platform technology. Nancy talks about the work patent attorney Peter Fasse of Fish & Richardson is doing for AltrixBio. Nancy’s decision to found her first company came from the conviction that all the work she had done as an executive and board member had prepared her to take the leap. Taking a company through an IPO with Goldman Sachs back in the 1990s taught Nancy the importance of being able to convey a compelling narrative about the company. Speaking of the daring required to start a company, Sal recalls his business partner Bob Smith’s audacious but well-founded belief that he could build his business in competition with big Wall Street names. Nancy’s views on de-risking startups is consonant with Jeff Arnold’s. Being an entrepreneur is wonderfully fun. Nancy finds Massachusetts a great place to build a biotech company. Sal notes that Boston is a big exporter of ideas and a big importer of capital. Two third of Series A funding of Boston companies is from outside Massachusetts.

Jeff Karp was inspired by porcupine quills to improve surgery. Perry Carver of the Bonnie and Clyde Ambush Museum reveals the tender side of Bonnie and Clyde. Oregon Health and Science University's Vinay Prasad reveals what happens when doctors realize treatment protocol is ineffective. Author Daniella Martin says that bugs should be a staple in everyone's diet. Cristina Zenato, shark professional, helps us to get away from the Hollywood portrayal of sharks.

Having an injection is an experience common to us all, and whether you are unfussed by them or they make you feel faint, the actual needle used is the same for everyone and highly standardised. But given different parts of the body are more difficult to inject than others, this is not ideal. Scientists at Harvard Medical School realised this problem and have set about creating a more adaptive solution that could lead to big changes in healthcare. Jack Tavener spoke to Jeff Karp, who co-authored the study, about the challenges his team faced... Like this podcast? Please help us by supporting the Naked Scientists

Having an injection is an experience common to us all, and whether you are unfussed by them or they make you feel faint, the actual needle used is the same for everyone and highly standardised. But given different parts of the body are more difficult to inject than others, this is not ideal. Scientists at Harvard Medical School realised this problem and have set about creating a more adaptive solution that could lead to big changes in healthcare. Jack Tavener spoke to Jeff Karp, who co-authored the study, about the challenges his team faced... Like this podcast? Please help us by supporting the Naked Scientists

What does it take to solve complicated and seemingly insurmountable challenges? Dr. Jeff Karp, Principal Investigator of Karp Lab & Harvard Medical School professor, believes the answer is a multidisciplinary approach. Surround yourself with experts who have expertise you don’t with a variety of skills and backgrounds. Karp explains to Joe De Sena how his team applied their problem-solving system to a specific challenge around brain cancer. It’s a system and process that can be applied to any puzzle. He is committed to developing the “next generation bioengineers at the forefront of regenerative medicine.” When you face Spartan challenges and obstacles as look for creative solutions. Collaborate and find new approaches to conquer our goals. LESSONS Always continue to learn Ask lots of questions and seek those that have the answers Validate those around you by allowing them to contribute Surround yourself with mission-driven people who have expertise varied from your own Focus on helping people and being a good mentor- give back to the next generation! Mistakes, even those on the stage, teach you LINKS http://www.karplab.net/ This episode of Spartan Up is sponsored by Elevate Hemp. Elevate Hemp Extract Cream in both Heat and Cool Therapy options deliver muscle pain and relief as it targets your body's muscle and cannabinoid receptors. Elevate your Life! Get 15% off your purchase at checkout when you use code SPARTAN15 at https://elevatehemp.com/shop/ TIME STAMPS 0:00 Col. Nye, Johnny Waite & Dr. L introduce Dr. Jeff Karp 1:00 Elevate beak 1:25 Interview with Joe & Dr. Karp begins - medical lab design at Harvard 2:30 starting six companies 4:00 multidisciplinary problem solving 5:45 developing a new approach to brain cancer 8:20 going “all in” 10:00 breaking down dogmas 11:45 meeting people in the entrepreneurial ecosystem 13:15 constantly be experimenting 13:50 31 Habits of Health Spartans: #7 “Tell Someone” 14:55 Elevate break 16:50 Interview continues: Joe tells the tale of Spartan Tea 18:00 Learning from a big mistake at a TEDMED talk about bioinspiration 21:00 Giving feedback to CNN & taking risks 26:00 Three things everyone should do 26:55 Colonel Nye, Johnny Waite and Dr. L discuss how to integrate Dr. Jeff Karp’s insights 34:30 Elevate Break 35:00 close SUBSCRIBE: Apple Podcasts: http://bit.ly/SpartanUpShow YouTube: http://bit.ly/SpartanUpYT Google Play: http://bit.ly/SpartanUpPlay FOLLOW SPARTAN UP: Spartan Up on Instagram https://www.instagram.com/spartanuppodcast/ Spartan Up on Twitter https://twitter.com/SpartanUpPod CREDITS: Producer – Marion Abrams, Madmotion, llc. Hosts: Joe De Sena, Johnny Waite, Colonel Nye & guest host Dr. L (Sefra Alexandra was on an expedition in the South Pacific) Synopsis – Sefra Alexandra Production Assistant - Andrea Hagarty © 2019 Spartan

Who would’ve thought that geckos could revolutionize medical technology? Jeff Karp, an associate professor at Boston’s Brigham and Women’s Hospital and Harvard Medical School, was inspired research in nature, most specifically by the gecko’s incredible ability to stick to vertical walls. And he realized that that ability - sticking and unsticking easily, without leaving a residue behind, like a band-aid does - could be useful in the hospital. And this nature-inspired realization was just the beginning. We visit Karp’s lab to learn about his inventions, his reverence for evolution, and his biomimetic vision.

First up, we examine a question that most kids ask at some point: “Where do babies come from?” Science writer Edward Dolnick walks us through how humanity discovered the answer to that question. And the story involves Leonardo Da Vinci, sea urchins, and staring at sperm under a primitive microscope. After that: What can scientists learn from the natural world? We visit the lab of Jeff Karp, a biomedical engineer who seeks inspiration from porcupines and geckos. Take a listen to find out how investigating sea slug slime led to the development of a glue that can adhere to almost any tissue in the human body. (The glue actually just received market approval in Europe.) Finally, humans are living longer and longer. What does that mean for our society? Andrew Scott, co-author of The 100-Year Life: Living and Working in an Age of Longevity, believes that we’re going to have to create entirely new stages* *of life.

Parents won’t shut up about their kids being precious. And with American birth rates declining, they’re actually right. Geckos can help us perform surgery, and kingfishers can help us design trains. We dive into the world of biologically-inspired design. Being lonely isn’t just bad for your emotional health, it’s bad for your physical health. We talk about why Americans are lonelier than ever and what can be done about it.

The key to advancing medicine might be found right in your backyard. Harvard’s Jeff Karp finds inspiration in nature to create medical solutions for humans.