Podcasts about Tohoku University

たばこの煙東北大は２９日までに、妊娠中に受動喫煙すると、出産前に胎盤の一部が子宮壁から剥がれる「常位胎盤早期剥離」の発症リスクが約２．３倍高まるとの研究結果を発表した。 Exposure to secondhand smoke during pregnancy increases by about 2.3 times the risk of placental abruption, a condition in which part of the placenta separates from the uterine wall before childbirth, according to a study conducted by a team from Japan's Tohoku University.

Exposure to secondhand smoke during pregnancy increases by about 2.3 times the risk of placental abruption, a condition in which part of the placenta separates from the uterine wall before childbirth, according to a study conducted by a team from Japan's Tohoku University.

A fascinating interspecies relationship can be seen among the horse breeding pastoralists in the Altai and Saian Mountains of Inner Asia. Growing up in a community with close human-horse relationships, in The Horse in My Blood: Multispecies Kinship in the Altai and Saian Mountains (Berghahn Books, 2024), Victoria Soyan Peemot uses her knowledge of the local language and horsemanship practices. Building upon Indigenous research epistemologies, she engages with the study of how the human-horse relationships interact with each other, experience injustices and develop resilience strategies as multispecies unions. Victoria Soyan Peemot is research fellow in Indigenous studies at the University of Helsinki supported by the Kone Foundation. Currently she is a JSPS visiting researcher at the Center for Northeast Asian Studies, Tohoku University. She is a cultural anthropologist who specialises in ethnography of mobile pastoralism in the transborder Altai and Saian Mountainous region of Inner Asia. Victoria's research interests include Indigenous research epistemologies, human-environment relationships, and museum anthropology. Yadong Li is a PhD student in anthropology at Tulane University. His research interests lie at the intersection of economic anthropology, medical anthropology, hope studies, and the anthropology of borders and frontiers. More details about his scholarship and research interests can be found here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

A fascinating interspecies relationship can be seen among the horse breeding pastoralists in the Altai and Saian Mountains of Inner Asia. Growing up in a community with close human-horse relationships, in The Horse in My Blood: Multispecies Kinship in the Altai and Saian Mountains (Berghahn Books, 2024), Victoria Soyan Peemot uses her knowledge of the local language and horsemanship practices. Building upon Indigenous research epistemologies, she engages with the study of how the human-horse relationships interact with each other, experience injustices and develop resilience strategies as multispecies unions. Victoria Soyan Peemot is research fellow in Indigenous studies at the University of Helsinki supported by the Kone Foundation. Currently she is a JSPS visiting researcher at the Center for Northeast Asian Studies, Tohoku University. She is a cultural anthropologist who specialises in ethnography of mobile pastoralism in the transborder Altai and Saian Mountainous region of Inner Asia. Victoria's research interests include Indigenous research epistemologies, human-environment relationships, and museum anthropology. Yadong Li is a PhD student in anthropology at Tulane University. His research interests lie at the intersection of economic anthropology, medical anthropology, hope studies, and the anthropology of borders and frontiers. More details about his scholarship and research interests can be found here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/central-asian-studies

A fascinating interspecies relationship can be seen among the horse breeding pastoralists in the Altai and Saian Mountains of Inner Asia. Growing up in a community with close human-horse relationships, in The Horse in My Blood: Multispecies Kinship in the Altai and Saian Mountains (Berghahn Books, 2024), Victoria Soyan Peemot uses her knowledge of the local language and horsemanship practices. Building upon Indigenous research epistemologies, she engages with the study of how the human-horse relationships interact with each other, experience injustices and develop resilience strategies as multispecies unions. Victoria Soyan Peemot is research fellow in Indigenous studies at the University of Helsinki supported by the Kone Foundation. Currently she is a JSPS visiting researcher at the Center for Northeast Asian Studies, Tohoku University. She is a cultural anthropologist who specialises in ethnography of mobile pastoralism in the transborder Altai and Saian Mountainous region of Inner Asia. Victoria's research interests include Indigenous research epistemologies, human-environment relationships, and museum anthropology. Yadong Li is a PhD student in anthropology at Tulane University. His research interests lie at the intersection of economic anthropology, medical anthropology, hope studies, and the anthropology of borders and frontiers. More details about his scholarship and research interests can be found here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology

A fascinating interspecies relationship can be seen among the horse breeding pastoralists in the Altai and Saian Mountains of Inner Asia. Growing up in a community with close human-horse relationships, in The Horse in My Blood: Multispecies Kinship in the Altai and Saian Mountains (Berghahn Books, 2024), Victoria Soyan Peemot uses her knowledge of the local language and horsemanship practices. Building upon Indigenous research epistemologies, she engages with the study of how the human-horse relationships interact with each other, experience injustices and develop resilience strategies as multispecies unions. Victoria Soyan Peemot is research fellow in Indigenous studies at the University of Helsinki supported by the Kone Foundation. Currently she is a JSPS visiting researcher at the Center for Northeast Asian Studies, Tohoku University. She is a cultural anthropologist who specialises in ethnography of mobile pastoralism in the transborder Altai and Saian Mountainous region of Inner Asia. Victoria's research interests include Indigenous research epistemologies, human-environment relationships, and museum anthropology. Yadong Li is a PhD student in anthropology at Tulane University. His research interests lie at the intersection of economic anthropology, medical anthropology, hope studies, and the anthropology of borders and frontiers. More details about his scholarship and research interests can be found here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

A fascinating interspecies relationship can be seen among the horse breeding pastoralists in the Altai and Saian Mountains of Inner Asia. Growing up in a community with close human-horse relationships, in The Horse in My Blood: Multispecies Kinship in the Altai and Saian Mountains (Berghahn Books, 2024), Victoria Soyan Peemot uses her knowledge of the local language and horsemanship practices. Building upon Indigenous research epistemologies, she engages with the study of how the human-horse relationships interact with each other, experience injustices and develop resilience strategies as multispecies unions. Victoria Soyan Peemot is research fellow in Indigenous studies at the University of Helsinki supported by the Kone Foundation. Currently she is a JSPS visiting researcher at the Center for Northeast Asian Studies, Tohoku University. She is a cultural anthropologist who specialises in ethnography of mobile pastoralism in the transborder Altai and Saian Mountainous region of Inner Asia. Victoria's research interests include Indigenous research epistemologies, human-environment relationships, and museum anthropology. Yadong Li is a PhD student in anthropology at Tulane University. His research interests lie at the intersection of economic anthropology, medical anthropology, hope studies, and the anthropology of borders and frontiers. More details about his scholarship and research interests can be found here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/animal-studies

東北大川内キャンパス、仙台市青葉区文部科学省は８日、１０兆円規模の大学ファンドを通じて支援する「国際卓越研究大学」の第１号に東北大を正式認定したと発表した。 Japan's education ministry said Friday that it has formally approved Tohoku University as the first recipient of subsidies under a state program aimed at strengthening academic research capabilities in the country.

Japan's education ministry said Friday that it has formally approved Tohoku University as the first recipient of subsidies under a state program aimed at strengthening academic research capabilities in the country.

A group of researchers from Japan's Tohoku University and others has invented a system for restarting within three minutes the blood circulation of an injured heart and obtained a patent for the invention.

東北大などの研究グループは１６日、負傷した心臓の血液循環を３分以内で再開させるシステムを考案し、同日までに特許を取得したと発表した。 A group of researchers from Japan's Tohoku University and others has invented a system for restarting within three minutes the blood circulation of an injured heart and obtained a patent for the invention.

Today, you'll learn about a newly discovered deep sea ghost shark, the best way to treat prolonged grief disorder, and how the blood vessels in our brain coordinate to improve brain functioning. Ghost Shark “‘Ghost shark' with enormous head and giant iridescent eyes discovered off Thailand.” by Elise Poore. 2024. “Chimaera.” Shark Trust. 2020. “Chimaera supapae (Holocephali: Chimaeriformes: Chimaeridae), a new species of chimaera from the Andaman Sea of Thailand.” by David A. Ebert, et al. 2024. Grief Treatment “Which therapy works best to treat prolonged grief disorder?” by Lachlan Gilbert. 2024. “Cognitive Behavior Therapy vs Mindfulness in Treatment of Prolonged Grief Disorder.” by Richard A. Bryant, et al. 2024. “Comparing the efficacy of mindfulness-based therapy and cognitive-behavioral therapy for depression in head-to-head randomized controlled trials: A systematic review and meta-analysis of equivalence.” by Kristine Tretto Sverre, et al. 2022. “Prolonged Grief Disorder.” Psychology Today. N.d. Blood Vessel Coordination “Coordinating Blood Vessel Activity Might be Associated with Better Brain Performance.” Tohoku University. 2024. “Plastic vasomotion entrainment.” by Daichi Sasaki, et al. 2024. Follow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. Hosted on Acast. See acast.com/privacy for more information.

【図解】国際卓越研究大学の仕組み文部科学省は１４日、１０兆円規模の大学ファンドを通じて支援する「国際卓越研究大学」の第１号に東北大を正式認定する手続きに入ると発表した。 Japan's education ministry said Friday it will start the procedures to formally approve Tohoku University as the first recipient of huge grants under the government's 10-trillion-yen university fund aimed at promoting world-class research projects.

Japan's education ministry said Friday it will start the procedures to formally approve Tohoku University as the first recipient of huge grants under the government's 10-trillion-yen university fund aimed at promoting world-class research projects.

Send us a Text Message.Rick Moody, an advocate for climate change action, will discuss the importance of acknowledging and addressing the threat of climate change, particularly in the context of aging. Individuals should acknowledge their fears in this arena but use humor to confront anxieties and take action to prepare for both mitigation and adaptation to climate change.In this program, you will discover:How personal experiences motivate people to act and how connecting with younger generations is crucial.How individuals can contribute to addressing climate change as consumers, investors, and citizensThe ongoing struggles and the importance of personal connections and intergenerational work in climate changeA message of hope and the belief that everyone can take action to address the climate crisis.Resources about several organizations focused on aging and climate and how to find other resources, including Third Act, Elders for Climate Action, Gray is Green, Friends of the Earth, and SierraAbout Rick Moody:Harry (Rick) Moody, Ph.D., retired as Vice President for Academic Affairs with AARP and is currently Visiting Faculty at Fielding Graduate University and Tohoku University in Japan. He previously served as Executive Director of the Brookdale Center on Aging at Hunter College and Chairman of the Board of Elderhostel (now Road Scholar). He is the author of many scholarly articles and books, including co-author of Aging: Concepts and Controversies, a gerontology textbook now in its 10th edition. His book The Five Stages of the Soul was published by Doubleday and has been translated into seven languages worldwide. He is the editor of the Human Values in Aging newsletter, with 5,000 subscribers monthly. In 2011, he received the Lifetime Achievement Award from the American Society on Aging, and in 2008, he was named by Utne Reader Magazine as one of the "50 Visionaries Who Are Changing Your World." His current book, Climate Change in an Aging Society, will be published next year by Routledge. He lives in San Mateo, California.Get in touch with Rick Moody:Buy Rick's Books: https://revolutionizeretirement.com/moodybooks Visit Rick's Website: https://climateandaging.org/ Visit Rick's LinkedIn Profile: https://www.linkedin.com/in/rick-moody-b1a660b/  What to do next: Click to grab our free guide, 10 Key Issues to Consider as You Explore Your Retirement Transition Please leave a review at Apple Podcasts. Join our Revolutionize Your Retirement group on Facebook.

A study from Japan's Tohoku University says that if current trends continue, everyone in the country will eventually end up with the same surname - though it might take a while to get there. Plus: some residents of Luna Pier, Michigan were apparently so concerned about eclipse tourists that the mayor says they asked him to stop the eclipse.  Everyone in Japan will be called Sato by 2531 unless marriage law changed, says professor (The Guardian) Solar Eclipse 2024: The only Michigan town that is in the path of totality (BridgeMI.com)  Add your name to our list of Patreon backers --- Send in a voice message: https://podcasters.spotify.com/pod/show/coolweirdawesome/message Support this podcast: https://podcasters.spotify.com/pod/show/coolweirdawesome/support

Harry R. Moody on 50 years in the field of aging and making the world a better place Harry “Rick” Moody, Ph.D., shares his opinions on positive aging, climate change, and the importance of finding meaning and purpose in later life. Gerontologist, professor, executive, speaker, writer, and activist, he is Distinguished Visiting Professor at Fielding Graduate University's Creativity and Wisdom Program and author of the hallmark textbook Aging: Concepts & Controversies, in its 10th edition. About Dr. Moody Harry R. Moody is a graduate of Yale University and received his Ph.D. in philosophy from Columbia University. He has taught philosophy at Columbia University, Hunter College, New York University, and the University of California at Santa Cruz.  He recently retired as Vice President and Director of Academic Affairs for AARP in Washington, DC.  He is currently Visiting Professor at Tohoku University in Japan, and Distinguished Visiting Professor at Fielding Graduate University's Creativity and Wisdom Program. Dr. Moody previously served as Executive Director of the Brookdale Center on Aging at Hunter College and Chairman of the Board of Elderhostel (now Road Scholar). Moody is the author of over 100 scholarly articles, as well as a number of books including: Abundance of Life: Human Development Policies for an Aging Society (Columbia University Press, 1988) and Ethics in an Aging Society (Johns Hopkins University Press, 1992). His most recent book, The Five Stages of the Soul, was published by Doubleday Anchor Books and has been translated into seven languages worldwide.  He is the editor of the Climate Change in an Aging Society and Human Values in Aging newsletters. In 2011 he received the Lifetime Achievement Award from the American Society on Aging and in 2008 he was named by Utne Reader Magazine as one of “50 Visionaries Who Are Changing Your World.” Key Takeaways Internalized ageism contributes to self-limiting beliefs, like: “I'm too old to play tennis anymore.” “I'm too old to learn to play an instrument,” You are never too old to learn. There are small things we can do for climate change that add up when you connect with other people doing small things. Begin where you are. Think globally, act locally. It is a false narrative to think you either act as an individual or act politically. You can and should do both because one reinforces the other. Positive aging begins by changing the way you think. Begin by believing there is always something you can do to make a difference in your own life and the lives of others. Aging is diminished reserve capacity. But that means reserve capacity. Decrement with compensation means recognizing there will be limitations and then finding an alternative (Ex: you can't run anymore, so you walk.) Look for opportunities, find them and act on them. Dreaming is a natural organic function of humans and all mammals. Dreams show us what we already know, but do not yet see. The young and old are the most vulnerable to loneliness and social isolation. Successful intergenerational connections require reciprocity and mentoring in both directions. To subscribe to Human Values in Aging and Climate Change in an Aging Society, email hrmoody@yahoo.com.

Japan's collectivistic approach to society enabled its citizens to “pull together” through the COVID pandemic - but has it become complacent in the face of future crises? Ben caught up with Heidi Larson, the co-founder of the Global Listening Project in Tokyo, as she shared initial learnings from the Project's 70 country opinion research study into societal preparedness with experts, as well as leading Japanese virologist Professor Hitoshi Oshitani, and Moderna's Dr Rachel Dawson to explore just how far the country's COVID response provides important lessons for the next crisis. Professor Hitoshi Oshitani, Professor of Virology, Tohoku University, Japan Dr. Rachel Dawson, Executive Director, Medical Affairs, Moderna Professor Heidi Larson, Co-Founder & Chair, The Global Listening Project https://global-listening.org http://www.tohoku.ac.jp/en https://www.modernatx.com https://www.ashotinthearmpodcast.com https://www.youtube.com/@shotarmpodcast #japan #COVID-19 #society #globallistening #resilience #preparedness #futurecrisis #HPV #influenza #vaccine #mRNA

HEALTH NEWS   ·         Intermittent fasting improves Alzheimer's pathology ·         Melatonin and its derivatives found to enhance long-term object recognition memory ·         Heat therapy boosts mitochondrial function in muscles ·         Too young for arthritis? 15% of global population over age 30 have condition ·         Decreased acetyl-L-carnitine levels associated with depression ·         Floatation Therapy for Specific Health Concerns      Intermittent fasting improves Alzheimer's pathology  University of California San Diego School of Medicine, August 21, 2023 One of the hallmarks of Alzheimer's disease is disruption to the body's circadian rhythm, the internal biological clock that regulates many of our physiological processes. Nearly 80% of people with Alzheimer's experience these issues, including difficulty sleeping and worsening cognitive function at night. However, there are no existing treatments for Alzheimer's that target this aspect of the disease. A new study from researchers at University of California San Diego School of Medicine has shown in mice that it is possible to correct the circadian disruptions seen in Alzheimer's disease with time-restricted feeding, a type of intermittent fasting focused on limiting the daily eating window without limiting the amount of food consumed. In the study, published in Cell Metabolism, mice that were fed on a time-restricted schedule showed improvements in memory and reduced accumulation of amyloid proteins in the brain. The authors say the findings will likely result in a human clinical trial. “Circadian disruptions in Alzheimer's are the leading cause of nursing home placement,” said Desplats. “Anything we can do to help patients restore their circadian rhythm will make a huge difference in how we manage Alzheimer's in the clinic and how caregivers help patients manage the disease at home.” Compared to control mice who were provided food at all hours, mice fed on the time-restricted schedule had better memory, were less hyperactive at night, followed a more regular sleep schedule and experienced fewer disruptions during sleep. The test mice also performed better on cognitive assessments than control mice, demonstrating that the time-restricted feeding schedule was able to help mitigate the behavioral symptoms of Alzheimer's disease. The researchers also observed improvements in the mice on a molecular level. In mice fed on a restricted schedule, the researchers found that multiple genes associated with Alzheimer's and neuroinflammation were expressed differently. They also found that the feeding schedule helped reduce the amount of amyloid protein that accumulated in the brain. Amyloid deposits are one of the most well-known features of Alzheimer's disease.     Melatonin and its derivatives found to enhance long-term object recognition memory Sophia University (Japan), August 21, 2023 Multiple studies have demonstrated the memory-enhancing effects of melatonin and its derivatives in animal models. It is also known that the formation of both short- and long-term memories require the phosphorylation of certain memory-related proteins. However, the molecular mechanisms underlying melatonin-induced memory enhancement have remained elusive. Now, medical researchers from Sophia University, Japan, have made important findings that contribute significantly to the elucidation of the underlying mechanisms in a recent article that was published NeuroReport on June 7, 2023. The research team, which included Dr. Masahiro Sano (currently affiliated with Tohoku University) and Dr. Hikaru Iwashita (currently affiliated with Kansai Medical University), examined the effects of three compounds on memory formation; these compounds were melatonin, a hormone secreted by the pineal gland located in the brain; N1-acetyl-5-methoxyquinuramine (AMK), melatonin's biological metabolite; and ramelteon, a drug that binds and activates the melatonin receptor. Initial experiments conducted on male mice clearly showed that the administration of melatonin, ramelteon, or AMK at a dose of 1 mg/kg facilitated the formation of long-term memory. The researchers did not investigate the effects of the three compounds on female mice to avoid any likely data variability resulting from the reproductive cycles occurring in female mammals. Prof. Chiba concludes, "Our findings suggest that melatonin is involved in promoting the formation of long-term object recognition memory by modulating the phosphorylation levels of memory-related proteins such as ERK, CaMKIIs, and CREB in both receptor-mediated and nonreceptor-mediated signaling pathways."   Heat therapy boosts mitochondrial function in muscles Brigham Young University, July 31, 2023 A new study finds that long-term heat therapy may increase mitochondrial function in the muscles. The discovery could lead to new treatments for people with chronic illness or disease.  Mitochondria, the "energy centers" of the cells, are essential for maintaining good health. Exercise has been shown to create new mitochondria and improve function of existing mitochondria. However, some people with chronic illnesses are not able to exercise long enough--previous research suggests close to two hours daily--to reap the benefits. Rodent studies have suggested that heat exposure may also induce the production of more mitochondria. Researchers from Brigham Young University in Utah studied 20 adult volunteers who had not participated in regular exercise in the three months prior to the study. The research team applied two hours of shortwave diathermy--a type of heat therapy generated by electrical pulses--to the thigh muscles of one leg of each person every day. The researchers based the six-day trial of heat on the minimum amount of exercise needed to measure changes in muscle, or about two hours each day. They designed the treatment to mimic the effects of muscle heating that occurs during exercise.  Mitochondrial function increased by an average of 28 percent in the heated legs after the heat treatment. The concentration of several mitochondrial proteins also increased in the heated legs, which suggests that "in addition to improving function, [repeated exposure to heat] increased mitochondrial content in human skeletal muscle," the research team wrote. "Our data provide evidence to support further research into the mechanisms of heat-induced mitochondrial adaptations," the researchers explained. People who are not able to exercise for long periods of time due to their health may benefit from [heat] treatments.   Too young for arthritis? 15% of global population over age 30 have condition Institute for Health Metrics and Evaluation (US), August 21, 2023 Arthritis is just a problem for the elderly, right? Not so fast. A recent study finds that osteoarthritis affects 15 percent of individuals over the age of 30 worldwide. Contributing factors include obesity, as well as an aging and growing global population. Remarkably, excess weight is responsible for 20 percent of these cases. Moreover, for those over 70, osteoarthritis ranks as the seventh leading cause of years people live with a disability. Experts forecast that by 2050, one billion people will be afflicted by this condition. Women tend to be more susceptible than men. The most commonly impacted areas include the hands, hips, knees, and other joints like the shoulders and elbows. By 2050, estimates predict a 78.6-percent increase in hip pain cases, 75 percent in the knee, 50 percent in the hand, and a staggering 95.1-percent increase in other areas. This research, led by the Institute for Health Metrics and Evaluation (IHME) in Seattle, assessed three decades of osteoarthritis data from over 200 countries. In 1990, the global count was 256 million individuals with osteoarthritis. By 2020, this number skyrocketed to 595 million, marking a 132-percent increase from 1990. The dramatic rise can be attributed to three primary causes: aging, population growth, and the obesity epidemic. The team's findings underscored the mounting influence of obesity over time as its rates have soared. They estimate that effectively addressing obesity could reduce the osteoarthritis burden by one-fifth.   Decreased acetyl-L-carnitine levels associated with depression Stanford University, July 30 2023  An article that appeared in the Proceedings of the National Academy of Sciences reported a link between low levels of acetyl-L-carnitine and a greater risk of depression. Acting on the findings of animal research conducted by lead author Carla Nasca, PhD, the researchers recruited men and women between the ages of 20 and 70 years who had been admitted to Weill Cornell Medicine or Mount Sinai School of Medicine for treatment of acute depression. Clinical assessments were conducted upon enrollment and blood samples were analyzed for levels of acetyl-L-carnitine. In comparison with levels measured in blood samples provided by 45 demographically matched healthy men and women, acetyl-L-carnitine blood levels in depressed subjects were substantially lower. Acetyl-L-carnitine levels were lowest among depressed patients who had severe symptoms, a history of treatment resistance, or early onset disease. Having a history of childhood abuse was also associated with low acetyl-L-carnitine levels. "We've identified an important new biomarker of major depression disorder,” Dr Rasgon stated. “We didn't test whether supplementing with that substance could actually improve patients' symptoms. What's the appropriate dose, frequency, duration? This is the first step toward developing that knowledge, which will require large-scale, carefully controlled clinical trials."   Floatation Therapy for Specific Health Concerns  Medical University of South Carolina, August 6, 2023 We conducted a search of multiple databases using the following search terms: float, floatation therapy, floatation REST, isolation tank, stress, relaxation response, magnesium sulfate, transdermal magnesium, cortisol, pain, depression, anxiety, sleep, and addiction.  The reviewed studies revealed benefits of floating, specifically regarding participants experiencing muscular pain, depression, anxiety, stress, and sleep disorders. Long-term benefits appear variable. Traditionally, isolation tanks are enclosed to inhibit light and sound as much as possible and reduce all incoming stimuli. The float experience minimizes sensory signals including visual, auditory, olfactory, thermal, tactile, and gravitational.  The studies discussed were conducted with the combination of water and Epsom salt. The salt-saturated water in most commercial centers is cleaned with a filtration system that runs between each session, in addition to manual skimming and treatment with ultraviolet light, hydrogen peroxide, and ozone. Generally, a float session lasts for 60 minutes, although it can be shorter or longer. The benefits of magnesium sulfate (MgSO4), better known as Epsom salt, are well known. The World Health Organization (WHO) lists it as an essential medication.   A proposed mechanism of action of the aforementioned benefits of floatation therapy lies in the transdermal absorption of MgSO4. Given the selectivity of the stratum corneum layer of the skin and the ionic nature of elemental magnesium, it appears that specific lipophilic carriers are required for MgSO4 to cross the dermal layer into the circulation. Among the benefits the analysis of studies suggest include: Pain:  Kjellgren and colleagues found a significant improvement with floatation therapy in those who experienced the most intense muscle pain (P=0.004), but there was no benefit found in participants who experienced lower levels of pain. There were 37 participants in this study, all of whom had chronic muscular pain of the neck and back regions. Individuals floated 9 times during a 3-week period. Of the 32 participants in this study, 22% became pain-free, 56% had improvement of pain, 19% experienced no increase or decrease of pain, and 3% experienced worsening of pain. Depression and Anxiety:  At the Laureate Institute for Brain Research in Tulsa, Oklahoma, researchers have extensively studied floatation therapy, particularly in the areas of depression and generalized anxiety disorder (GAD). One study involving 50 participants at LIBR examined the anxiolytic and antidepressant effects of floating. Results showed a significant reduction in anxiety among participants, regardless of gender. All changes were significant. Anxiety and stress-related disorders in this study included post-traumatic stress disorder, generalized anxiety disorder, panic disorder, agoraphobia, and social anxiety disorder. In addition to reduced anxiety, there was a significant improvement in mood characterized by “serenity, relaxation, happiness, positive affect, overall well-being, energy levels, and feeling refreshed, content and peaceful.” Stress:  Research generally finds floatation therapy to be beneficial for stress reduction. The relaxation response (which is associated with the parasympathetic nervous system) occurs when floating, lowering blood pressure and lowering cortisol levels in some studies.  Sleep:  People have used floatation therapy to aid with sleep. Since magnesium is a common supplement used to aid with sleep, this is a logical area of float research interest. In a study looking at 19 athletes and floating, participants not only had improved athletic performance recovery, but also experienced significant improvements in having “deeper sleep, fewer awakenings during the night, and a sense of renewed energy upon awakening in the morning.”

Singaporean Prime Minister Lee Hsien Loong and Malaysian Prime Minister Anwar Ibrahim both wrapped up state visits to China last week and their discussions with President Xi Jinping revealed some fascinating linkages between contemporary Chinese foreign policy objectives and Beijing's historical perception of its role as Asia's central power.Antoine Roth, an international relations scholar at Tohoku University in Japan explores those themes in his new book "A Hierarchical Vision of Order: Understanding Chinese Foreign Policy in Asia." He joins Eric & Cobus from Sendai to discuss what lessons can be drawn from China's diplomatic history in Asia that can inform a better understanding of contemporary trends in Chinese foreign policy in other parts of the world.SHOW NOTES:Amazon: A Hierarchical Vision of Order: Understanding Chinese Foreign Policy in Asia by Antoine Roth: https://amzn.to/3m532qNJOIN THE DISCUSSION:Twitter: @ChinaGSProject| @stadenesque | @eric_olander | @antoinerothFacebook: www.facebook.com/ChinaAfricaProjectFOLLOW CAP IN FRENCH AND ARABIC:Français: www.projetafriquechine.com | @AfrikChineعربي: www.akhbaralsin-africia.com | @AkhbarAlSinAfrJOIN US ON PATREON!Become a CAP Patreon member and get all sorts of cool stuff, including our Week in Review report, an invitation to join monthly Zoom calls with Eric & Cobus, and even an awesome new CAP Podcast mug!www.patreon.com/chinaafricaprojectSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Singaporean Prime Minister Lee Hsien Loong and Malaysian Prime Minister Anwar Ibrahim both wrapped up state visits to China last week and their discussions with President Xi Jinping revealed some fascinating linkages between contemporary Chinese foreign policy objectives and Beijing's historical perception of its role as Asia's central power.Antoine Roth, an international relations scholar at Tohoku University in Japan explores those themes in his new book "A Hierarchical Vision of Order: Understanding Chinese Foreign Policy in Asia." He joins Eric & Cobus from Sendai to discuss what lessons can be drawn from China's diplomatic history in Asia that can inform a better understanding of contemporary trends in Chinese foreign policy in other parts of the world.SHOW NOTES:Amazon: A Hierarchical Vision of Order: Understanding Chinese Foreign Policy in Asia by Antoine Roth: https://amzn.to/3m532qNJOIN THE DISCUSSION:Twitter: @ChinaGSProject| @stadenesque | @eric_olander | @antoinerothFacebook: www.facebook.com/ChinaAfricaProjectFOLLOW CAP IN FRENCH AND ARABIC:Français: www.projetafriquechine.com | @AfrikChineعربي: www.akhbaralsin-africia.com | @AkhbarAlSinAfrJOIN US ON PATREON!Become a CAP Patreon member and get all sorts of cool stuff, including our Week in Review report, an invitation to join monthly Zoom calls with Eric & Cobus, and even an awesome new CAP Podcast mug!www.patreon.com/chinaafricaproject

This is episode number 105 & guest number 99. An article in the Speaking tree column of the Times of India Introduced me to the concept of Uketamo and quoted Yamabushi Tim Bunting who was born in New Zealand. After graduating from International University (IPC) located in Palmerston North, New Zealand, he applied for the JET Program run by the Japanese government and was sent to Shonai as an assistant language teacher. Tim also holds a master's degree in applied linguistics from the Victoria University of Wellington and currently teaches English at Tohoku University of Community Service and Science. In addition to his teaching career, he has also made a name for himself as the "Kiwi Yamabushi" and works fervently to promote both the charm of the Dewa Sanzan as well as Yamabushi culture abroad on both his YouTube channel and his blog. Listen in as he shares about the mystical qualities of everything Japanese, the mountains, The people, the food, Uketamo, Zen meditation, & being a Yamabushi. Learn more at https://timbunting.com/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/the-third-eye1/message

VIDEOS: Video Emerges Where Fauci and Others Planned for a “Universal mRNA Flu Vaccine” Which Became the “COVID-19 mRNA Vaccine” Because People were not Afraid Enough of the Flu Virus (1:51) You're Not Going To Believe This! | Mark Steyn & Eva Vlaardingerbroek (3:03) Neil Oliver – ‘…it's a toxic hell…' (START @ 9:00) Gravitas: Who helped Taliban repair the abandoned American aircraft? (7:25)   Healthy plant-based diets associated with lower colorectal cancer risk in men Kyung Hee University, South Korea, November 28, 2022 Eating a plant-based diet rich in healthy plant foods—such as whole grains, vegetables, and legumes—and low in unhealthy plant foods—including refined grains, fruit juices, and added sugars—is associated with a lower risk of colorectal cancer in men. The findings are published in the open access journal BMC Medicine.Jihye Kim, the corresponding author, said, “Colorectal cancer is the third-most common cancer worldwide, and the risk of developing colorectal cancer over a lifetime is one in 23 for men and one in 25 for women. Although previous research has suggested that plant-based diets may play a role in preventing colorectal cancer, the impact of plant foods' nutritional quality on this association has been unclear. Our findings suggest that eating a healthy plant-based diet is associated with a reduced risk of colorectal cancer.” Researchers from Kyung Hee University, South Korea found that among a population of 79,952 American men, those who ate the highest average daily amounts of healthy plant-based foods had a 22% lower risk of colorectal cancer, compared to those who ate the lowest amounts of healthy plant foods. However, the authors did not identify any significant associations between the nutritional quality of plant-based diets and colorectal cancer risk among a population of 93,475 American women. Jihye Kim said, “We speculate that the antioxidants found in foods such as fruits, vegetables, and whole grains could contribute to lowering colorectal cancer risk by suppressing chronic inflammation, which can lead to cancer. As men tend to have a higher risk of colorectal cancer than women, we propose that this could help explain why eating greater amounts of healthy plant-based foods was associated with reduced colorectal cancer risk in men but not women.” The authors found that the association between the nutritional quality of plant-based diets and colorectal cancer risk among men varied by race and ethnicity. Among Japanese American men, colorectal cancer risk was 20% lower for those who ate the highest amount of healthy plant foods per day than for those who ate the lowest amount. Among white men, those who ate the highest amount of highest amount of healthy plant foods had a 24% lower colorectal cancer risk than those who ate the lowest amount. The authors did not identify any significant associations between plant-based diets and colorectal cancer risk among African American, Latino or Native Hawaiian men. (next) Green Mediterranean diet reduces twice as much visceral fat as traditional Mediterranean diet Ben-Gurion University of the Negev (Israel), November 28, 2022 Following the green Mediterranean diet significantly reduces visceral adipose tissue, a type of fat around internal organs that is much more dangerous than the extra “tire” around your waist. Recently, researchers compared the green Mediterranean diet to the traditional Mediterranean diet and a non-Mediterranean healthy diet in a large-scale clinical interventional trial—the DIRECT PLUS. Subsequent analysis found that the green Mediterranean diet reduced visceral fat by 14%, the Mediterranean diet by 7% and the non-Mediterranean healthy diet by 4.5%. The study was published in BMC Medicine. Reducing visceral fat is considered the true goal of weight loss, as it is a more important indicator than a person's weight or the circumference of their waist. Visceral fat aggregates over time between organs, and produces hormones and poisons linked to heart disease, diabetes, dementia and premature death. The DIRECT-PLUS trial research team was the first to introduce the concept of the green Mediterranean diet. This modified Mediterranean diet is further enriched with dietary polyphenols and is lower in red/processed meat than the traditional Mediterranean diet. On top of a daily intake of walnuts (28 grams), the participants consumed 3-4 cups of green tea/day and 100 grams (frozen cubes) of duckweed green shake/day. The aquatic green plant duckweed is high in bioavailable protein, iron, B12, vitamins, minerals, and polyphenols and substituted meat intake. The team has shown in previous studies that the green Mediterranean diet has a variety of salutary effects ranging from the microbiome to age-related degenerative diseases. A group of 294 participants took part in the 18-month long trial. “A 14% reduction in visceral fat is a dramatic achievement for making simple changes to your diet and lifestyle. Weight loss is an important goal only if it is accompanied by impressive results in reducing adipose tissue,” notes Dr. Hila Zelicha. (next) Are older women being over-screened for cervical cancer? University of Illinois at Chicago, November 28, 2022 A new study published in JAMA Internal Medicine suggests that women over the age of 65 may be undergoing unnecessary cervical cancer screenings and that more public health data is needed on the utilization of cervical cancer screening-associated services among older women to prevent potential harm and unnecessary costs. The study, which is authored by experts from the University of Illinois Chicago, the University of California San Francisco and the U.S. Centers for Disease Control and Prevention, looked at Medicare claims data from 1999 to 2019 for fee-for-service care for women over the age of 65. The analysis showed that in 2019 more than 1.3 million women received cervical cancer screening-associated services, such as a Pap test, colposcopy, and other cervical procedures after age 65. While these services cost more than $83 million, the researchers concluded they were of “unclear clinical appropriateness.” “Cervical cancer screening and other preventive services are among our most important tools for keeping people healthy throughout life, but screenings should also follow evidence-based guidelines to prevent overspending, potential complications and patient discomfort,” said study co-author Dr. Hunter Holt, assistant professor of family and community medicine at the University of Illinois Chicago. According to recommendations and guidelines from the U.S. Preventive Services Task Force, the American Cancer Society and the American College of Obstetrics and Gynecology, women considered to be of average risk can stop undergoing routine cervical cancer screening once they reach the age of 65 if they have had adequate prior screening. “The decision to end cervical cancer screening for women after age 65 requires review of past screening results and related medical history. This process can promote cervical cancer prevention and prevent harms and costs from unnecessary tests and procedures,” said Jin Qin, study co-author and epidemiologist in CDC's Division of Cancer Prevention and Control. The researchers say that the high rates of screening among older women is potentially concerning. “It could be that women are getting screened when they do not need to, or that these women are considered to be at higher-than-average risk, for example, because they have not been adequately screened prior to 65. We do not want to see either of these things and unfortunately, there is not enough public health data to shed light on the causes,” said Holt, who is also affiliated with the University of Illinois Cancer Center at UIC. (next) Chemotherapy could increase disease susceptibility in future generations Washington State University, November 28, 2022 A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates. The study, published online in iScience, found that male rats who received the drug ifosfamide during adolescence had offspring and grand-offspring with increased incidence of disease. While other research has shown that cancer treatments can increase patients' chance of developing disease later in life, this is one of the first-known studies showing that susceptibility can be passed down to a third generation of unexposed offspring. “The findings suggest that if a patient receives chemotherapy, and then later has children, that their grandchildren, and even great-grandchildren, may have an increased disease susceptibility due to their ancestors' chemotherapy exposure,” said Michael Skinner, a WSU biologist and corresponding author on the study. Given this study's implications, the researchers recommend that cancer patients who plan to have children later take precautions, such as using cryopreservation to freeze sperm or ova before having chemotherapy. In the study, researchers exposed a set of young male rats to ifosfamide over three days, mimicking a course of treatment an adolescent human cancer patient might receive. Those rats were later bred with female rats who had not been exposed to the drug. The resulting offspring were bred again with another set of unexposed rats. The first-generation offspring had some exposure to the chemotherapy drug since their fathers' sperm was exposed, but researchers found greater incidence of disease in not only the first- but also the second-generation, who had no direct exposure to the drug. While there were some differences by generation and sex, the associated problems included greater incidence of kidney and testis diseases as well as delayed onset of puberty and abnormally low anxiety, indicating a lowered ability to assess risk. The results of the researchers' analysis showed epigenetic changes in two generations linked to the chemotherapy exposure of the originally exposed rats. The fact that these changes could be seen in the grand-offspring, who had no direct exposure to the chemotherapy drug, indicates that the negative effects were passed down through epigenetic inheritance. (next) Saffron can fight liver cancer, reveal UAE researchers United Arab Emirates University, November 20, 2022 It may be an expensive spice but you cannot put a label or price on health, said Professor Amr Amin who has researched a breakthrough in the properties of saffron in fighting liver cancer. Professor Amin from Cellular & Molecular Biology at United Arab Emirates University said that researchers have investigated and found saffron to have anti-liver cancer properties. “Safranal, a major biomolecule of the golden spice saffron arrests and stops the cancer cell division at two different stages,” he said. The UAE researchers have been working on this project since 2011 when they first published the research in the Hepatology Journal. The study suggests a novel mechanism of anti-proliferative activity of safranal against human liver cancer cells. “This molecule could serve as a novel and/or adjuvant drug to treat liver cancer,” said Dr Amin. The findings are now also published in a Nature journal Scientific Reports. “The ingredient works in two ways; it stops cell division and promotes cell death,” he explained. Prof Amin and colleagues concluded that safranal exerts its anticancer effect in HepG2 cells by inhibiting DNA repair, resulting in increased DNA damage. (next) Japanese researchers say that ultrasound therapy can be used to treat patients with dementia Tohoku University (Japan), November 20, 2022 A new therapy based on ultrasound waves might be able to improve the cognitive powers of patients suffering from Alzheimer's disease and other forms of dementia. According to an article on the Tohoku University news page, the approach improved the condition of mice with symptoms similar to human dementia. In their experiment, the Tohoku University research team sent low-intensity pulsed ultrasound (LIPUS) waves through the brain of the mice. They found that the waves improved the creation of blood vessels and the rate of regeneration of nerve cells. Furthermore, the treatment did not cause any notable side effects on the mice. The results led the researchers to believe that they can replicate their experimental success in actual human patients one day. “The LIPUS therapy is a non-invasive physiotherapy that could apply to high-risk elderly patients without the need for surgery or anaesthesia, and could be used repeatedly,” explained TU researcher Hiroaki Shimokawa. The Tohoku researchers applied LIPUS therapy to the whole brain of mice with symptoms that resemble those of Alzheimer's disease or vascular dementia. They did this three times a day, with each session lasting for 20 minutes. The mice that simulated vascular dementia underwent surgery that reduced the amount of blood that reached the brain. These animals underwent LIPUS treatment on the first, third, and fifth days after that surgery. Meanwhile, the mice that modeled Alzheimer's disease got 11 LIPUS treatments over a three-month-long trial period. By the end of the experiment, the researchers found that LIPUS activated genes involved with the cells that made up the inner lining of blood vessels. Furthermore, an enzyme that promoted blood vessel formation displayed increased activity, as did a protein which helped nerve cells grow. Based on their findings, whole-brain LIPUS therapy can help alleviate the symptoms of certain forms of dementia by encouraging the development of cells that are normally affected by the condition. The technique is currently undergoing initial clinical trials that will determine its efficacy and safety.

Japan's Green Transformation Plan is the latest national strategy in pursuit of energy transition and carbon neutrality by 2050. As a major economy with probably the highest energy efficiency standard and greatest dependency on fossil fuels import around the world, Japan faces a range of challenges. Professor Jusen Asuka from Tohoku University in Japan discusses how the new policies on offshore wind and solar PV may play a big part and why the next generational nuclear power technology could be a double-edged sword. His argument on Japan's cautious role in China-US contest in low carbon technology and investment resulted from a series of American legislation, particularly, climate policy embedded in Inflation Reduction Act (IRA), suggests some relevant policy implications for Japan. Finally, his reading suggestion touches intergenerational justice, one of the most compelling issues on climate governance.

That was Behrang Poorganji. Behrang is the VP of Materials Technology at Morf3d. He holds a PhD in metallurgy and materials processing from Tohoku University, Sendai, Japan and he has spent his career working in advanced metallic materials processing. He has worked as a senior advisor and consultant, helping to drive the adoption of AM in both domestic and international markets. Before Morf3D, he served as Professor and Director of Advanced Manufacturing at The University of Toledo, Ohio, USA. Before we get started head over to www.3degreescompany.com and subscribe to the podcast. Remember you can listen to the show anywhere you download your podcasts including Spotify, Apple, Amazon, or Stitcher.

Dr. Masaaki Higashijima is an Associate Professor of Political Science in the Graduate School of Information Sciences at Tohoku University in Japan. Holding a Ph.D. in Political Science from Michigan State University, his research interests include comparative political economy, autocratic politics, regime change, ethnic politics, Central Asia, and political methodology. His latest book is titled The Dictator's Dilemma at the Ballot Box: Electoral Manipulation, Economic Maneuvering, and Political Order in Autocracies.

Podcast: Control System Cyber Security Association International: (CS)²AIEpisode: 47: From Academia to CyberSecurity ExecutivePub date: 2022-08-23We have another interesting episode in our series of interviews with cybersecurity leaders and practitioners in the industrial controls systems or operating technology space.Derek Harp is excited to have Ron Indeck, the CEO of Q-Net Security, and a Director, Founder, and Technology Advisor to Exegy and VelociData joining him on the show. Ron grew up in Minneapolis, Minnesota, and got his degrees from the University of Minnesota. He is an inventor (he holds more than 100 patents), a distinguished professor at Washington University, a fellow at IEEE and several other professional organizations, an expert in all things magnetic, a serial entrepreneur, a scuba diver, and a father. In this episode of the (CS)²AI Podcast, Ron discusses his career journey and shares his unique perspective on cybersecurity. He also offers some gold nuggets of career advice and gives insight into upcoming trends in the cybersecurity space.You won't want to miss this episode if you are looking for career inspiration or are interested in moving from the academic space into the world of cybersecurity. Stay tuned for more!Show highlights:Ron discusses his career path and his motivation for becoming an entrepreneur.Ron's approach to his work at Washington University.Why did he transition across various engineering disciplines before ending up in research and patents?Ron's introduction to security came early on in his career while working with people from the FBI.How security for industrial control systems evolved throughout Ron's career.How Ron built his patent portfolio.Ron's approach to solving the generational cybersecurity problem.What made Ron decide to leave his successful academic career to become an entrepreneur?Exciting and rewarding possibilities exist for academics in the industrial technology space.How can you get into tech transfer?Ron talks about his work at the Airforce Research Laboratory.How to recognize an opportunity.Teamwork and cooperation are vital for success.Ron defines the term hardsec and compares it with a software approach to security solutions for the future.Why does Ron believe that cybersecurity is an issue of human rights?You can create exciting and rewarding career opportunities in cybersecurity.Bio:Ronald S. Indeck, Ph.D., received degrees from the University of Minnesota. He is CEO of Q-Net Security and a Director, Founder, and Technology Advisor to Exegy and VelociData. He was a National Science Foundation Research Fellow at Tohoku University in Sendai, Japan. From 1988 to 2009 he was in the Department of Electrical Engineering at Washington University where he was the Das Family Distinguished Professor and Director of the Center for Security Technologies.He has published more than 60 peer-reviewed technical papers and been awarded more than a hundred patents including MagnePrint. He has received many awards including the NSF Presidential Young Investigator Award from President Bush, the Missouri Bar Association Inventor of the Year, the IBM Faculty Development Award, the Washington University Distinguished Faculty Award, and the IEEE Centennial Key to the Future Award, and the IEEE Young Professional Award. He is a Fellow of the IEEE, a member of the American Physical Society, and many other professional organizations. He has served on many local committees and group activities, was on the board of the FBI InfraGard, chaired sessions, and served at several international conferences including General Chairman for International Magnetics Conference, was an editor for the IEEE Transactions on Magnetics, President of the IEEE Magnetics Society, and IEEE Magnetics Society Distinguished Lecturer. Specialties: Indeck is experienced in cybersecurity, heterogeneous computing, data mining in massive databases, magnetic measurements and modeling, physical security and authentication, recording physics, and magnetic devices.The podcast and artwork embedded on this page are from Derek Harp, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

We have another interesting episode in our series of interviews with cybersecurity leaders and practitioners in the industrial controls systems or operating technology space. Derek Harp is excited to have Ron Indeck, the CEO of Q-Net Security, and a Director, Founder, and Technology Advisor to Exegy and VelociData joining him on the show.  Ron grew up in Minneapolis, Minnesota, and got his degrees from the University of Minnesota. He is an inventor (he holds more than 100 patents), a distinguished professor at Washington University, a fellow at IEEE and several other professional organizations, an expert in all things magnetic, a serial entrepreneur, a scuba diver, and a father.  In this episode of the (CS)²AI Podcast, Ron discusses his career journey and shares his unique perspective on cybersecurity. He also offers some gold nuggets of career advice and gives insight into upcoming trends in the cybersecurity space. You won't want to miss this episode if you are looking for career inspiration or are interested in moving from the academic space into the world of cybersecurity. Stay tuned for more! Show highlights: Ron discusses his career path and his motivation for becoming an entrepreneur. Ron's approach to his work at Washington University. Why did he transition across various engineering disciplines before ending up in research and patents? Ron's introduction to security came early on in his career while working with people from the FBI. How security for industrial control systems evolved throughout Ron's career. How Ron built his patent portfolio. Ron's approach to solving the generational cybersecurity problem. What made Ron decide to leave his successful academic career to become an entrepreneur? Exciting and rewarding possibilities exist for academics in the industrial technology space. How can you get into tech transfer? Ron talks about his work at the Airforce Research Laboratory. How to recognize an opportunity. Teamwork and cooperation are vital for success. Ron defines the term hardsec and compares it with a software approach to security solutions for the future. Why does Ron believe that cybersecurity is an issue of human rights? You can create exciting and rewarding career opportunities in cybersecurity. Bio: Ronald S. Indeck, Ph.D., received degrees from the University of Minnesota. He is CEO of Q-Net Security and a Director, Founder, and Technology Advisor to Exegy and VelociData.  He was a National Science Foundation Research Fellow at Tohoku University in Sendai, Japan. From 1988 to 2009 he was in the Department of Electrical Engineering at Washington University where he was the Das Family Distinguished Professor and Director of the Center for Security Technologies. He has published more than 60 peer-reviewed technical papers and been awarded more than a hundred patents including MagnePrint. He has received many awards including the NSF Presidential Young Investigator Award from President Bush, the Missouri Bar Association Inventor of the Year, the IBM Faculty Development Award, the Washington University Distinguished Faculty Award, and the IEEE Centennial Key to the Future Award, and the IEEE Young Professional Award.  He is a Fellow of the IEEE, a member of the American Physical Society, and many other professional organizations. He has served on many local committees and group activities, was on the board of the FBI InfraGard, chaired sessions, and served at several international conferences including General Chairman for International Magnetics Conference, was an editor for the IEEE Transactions on Magnetics, President of the IEEE Magnetics Society, and IEEE Magnetics Society Distinguished Lecturer.  Specialties: Indeck is experienced in cybersecurity, heterogeneous computing, data mining in massive databases, magnetic measurements and modeling, physical security and authentication, recording physics, and magnetic devices. Mentioned in this...

Episode 27: “The Psychiatry of COVID-19” A Conversation with Dr. Emanuel Garcia “BIGGEST Disaster in Medical History!” ~ Dr Charles Hoffe Gives Riveting Speech In Vancouver, British Columbia, Canada Kim Iversen: Proof IRS Expansion Of 87,000 New Agents Is Designed To Target Middle Class Americans   Study: Regular consumption of citrus fruits can reduce dementia risk by 15% Tohoku University (Japan), August 4, 2022 Dementia continues to affect more people worldwide, and countries with aging populations like Japan are especially vulnerable. To address this matter, researchers from Tohoku University studied the health benefits of eating citrus fruits. According to the study findings, regular consumption of citrus fruits like oranges, grapefruits, lemons or limes could help reduce the risk of dementia among older adults by almost 15 percent. The research team hopes that the dietary approach could be both a simple and effective solution for dementia prevention. Findings from some cell and animal experiments have shown that citrus flavonoids can cross the blood-brain barrier and play a part in antioxidant and anti-inflammatory actions. Earlier studies suggest that this could help reverse and repair some forms of cellular damage. (next) Olive oil consumption found to reduce risk of death due to cancer, heart disease and Alzheimer's Harvard School of Public Health, August 14, 2022 According to a study, replacing butter or full-dairy fat with half a tablespoon or more of olive oil can help increase your chances of living longer. The study was conducted by experts from the Harvard T.H. Chan School of Public Health and published in the American Journal of Cardiology. The study revealed that people who used seven grams or more (at least half a tablespoon) of olive oil as a dressing or with bread had a reduced risk of dying from Alzheimer's disease, cancer, heart disease or respiratory disease compared to those who rarely or never consumed olive oil. Findings also showed that replacing 10 grams a day (about 3/4 tablespoons ) of butter, margarine, mayo or dairy fat with the same amount of olive oil was linked to an impressive eight to 34 percent lower risk of disease-related death. For the study, the researchers analyzed data from 60,582 healthy adult women and 31,801 healthy adult men from the Nurses' Health Study and the Health Professionals Follow-up Study. During the 28-year follow-up, the volunteers had a diet assessment every four years that asked them how often they consumed certain foods, fats and oils on average. The assessment also checked which brand or type of oils they used for cooking or at the table. (next) Cutting 1 gram from daily salt intake could ward off nearly 9 million cases of stroke/heart disease British Medical Journal, August 16, 2022 A modest cut of just 1 gram in daily salt intake could ward off nearly 9 million cases of heart disease and strokes and save 4 million lives by 2030, suggest the estimates of a modeling study published in the open access journal BMJ Nutrition Prevention & Health. Salt intake in China is one of the highest in the world, averaging 11 g/day—over twice the amount recommended by the Chinese government. High salt intake drives up blood pressure and therefore the risk of cardiovascular disease, which accounts for 40% of all deaths in China every year. The researchers set out to estimate the health gains that could be achieved by reducing salt intake across the nation, with the aim of helping to inform the development of a doable salt reduction program. Given that, on average, adults in China consume 11 g/day of salt, reducing this by 1 g/day should lower average systolic blood pressure by about 1.2 mmHg. And if this reduction were achieved in a year and sustained, some 9 million cases of heart disease and stroke could be prevented by 2030—4 million of them fatal. (next) Getting Adequate Amount Of Vitamin D Prevents Harmful Inflammation University of South Australia, August 7, 2022 A little bit of inflammation is integral to the human body's natural healing process. Chronic inflammation, however, can actually have the opposite effect. Constantly high levels increase one's risk of various serious diseases including but not limited to Type 2 diabetes, heart disease, and various autoimmune conditions. Now, a study by scientists at the University of South Australia reports a direct link between low levels of vitamin D and high levels of inflammation. This is the world's first ever genetic research project to focus on this topic. Study authors believe their work establishes an invaluable biomarker for identifying individuals at a higher risk of developing chronic illnesses with an inflammatory component. The research team used Mendelian randomization on the genetic data of 294 ,970 participants enrolled in the UK Biobank project. That analysis revealed a clear association between vitamin D and C-reactive protein levels, considered an indicator of inflammation. (next) Four Natural Options for Chronic Fatigue Syndrome GreenMedInfo, August 16th 2022 Chronic fatigue syndrome (CFS) is a complex long-term disorder affecting over 2 million Americans that is characterized by extreme fatigue and malaise that doesn't improve with rest.[i] A whopping 90% of chronic fatigue sufferers are undiagnosed[ii] and may find it difficult to carry on with normal activities such as work, school and household chores. At least 1 in 4 CFS patients are house-bound or bed-bound for long periods of time due to the disorder. While some studies demonstrate correlation between CFS and autoimmune system dysregulation,[v],[vi] the cause of CFS, also referred to as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is still unknown. There is no known cure for CFS, with treatment generally focusing on symptom relief.We've identified four of the best natural options for chronic fatigue syndrome to provide safe, effective support to revitalize your body and spirit. Nicotinamide Adenine Dinucleotide (NADH) An essential element in the production of energy, nicotinamide adenine dinucleotide (NADH) is a coenzyme found in every cell in the human body. NADH is a critical factor in hundreds of metabolic processes, including healthy cell turnover (antiaging), converting food into energy and maintaining the integrity of DNA,[ix] an important factor in disease prevention. NADH has been studied extensively as a therapeutic for CFS, including a study comparing oral NADH with conventional therapy consisting of nutritional supplements and psychological therapy for a period of 24 months. To rule out specific comorbidities, immunological parameters and viral antibody titers were also evaluated at baseline and each trimester of therapy. Patients who received NADH had a dramatic and statistically significant reduction in symptoms during the first trimester.[x] Another trial on the stabilized oral form of NADH examined 26 qualified patients over a 12-week double-blind, placebo-controlled study. Subjects were randomized to receive either 10 milligrams (mg) of NADH or placebo for a four-week period, followed by a four-week “washout” period, after which subjects were switched to the alternate treatment for a final four-week period. Within this cohort of 26 subjects, eight patients, or 31%, responded favorably to NADH compared to just 8% (two patients) of the placebo group, with no severe adverse reactions related to treatment.[xi] Astragalus Astragalus is a traditional herbal remedy known for its adaptogenic qualities, meaning it can help protect the body from damage due to oxidative stress. A powerful antioxidant, astragalus is used to protect and support immunity, as a preventative against colds and upper respiratory tract infections, and to regulate healthy blood pressure, among other uses.[xii] Astragalus can even be applied topically for wound care thanks to antiviral properties. A 2009 study focused on the herbal formula Myelophil, a combination of two traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza, a member of the sage family. The Myelophil extract was given to the treatment cohort in either low- or high-dose groups of 3 or 6 grams of Myelophil daily. A control group was provided with a placebo and all groups were monitored for four weeks. Patients were surveyed for symptom severity and blood antibody arrays were taken to measure inflammatory cytokines, an important marker of disease symptoms. Results showed that even at low dosage (3 grams), Myelophil significantly decreased fatigue severity compared with placebo, though no changes in cytokine expression were noted.[xiii] Probiotics Probiotics have garnered the health spotlight in recent years, owing to their ability to support and protect the digestive tract. But probiotics can do more than improve gut health — they may also boost your brain and improve your mood. Brain fog is a key side effect of CFS and a potentially devastating one when it comes to impact on daily functioning. The same can be said for depression, another common hallmark of CFS. Studies reflecting the mood-boosting, clarity-producing effects of probiotics are cause for optimism for sufferers of chronic fatigue. A 2018 study in the journal Beneficial Microbes points to the role gut microbiota may play in CFS and fibromyalgia syndrome (FMS), which shares many features of CFS. A systematic review of studies was performed in this meta-analysis, encompassing randomized controlled trials and pilot studies of CFS or FMS conducted between 2006 and 2016. The administration of Lactobacillus casei for eight weeks was found to reduce anxiety scores, while treatment with Bifidobacterium infantis for the same period reduced inflammatory biomarkers.[xiv] Unhealthful intestinal ecology may play a role in CFS, as it plays a part in the health of the immune system. A 2009 study on probiotics' effects on energy level and symptomology for CFS patients found that, after four weeks of probiotic supplementation with strains of lactobacillus, acidophilus and Bifidobacterium, patients reported improved neurocognitive functions, though fatigue and physical activity scores were not significantly affected.[xv] Antioxidant Formulas Supplementing with antioxidants is another way to boost your body's defenses against the damaging effects of free radicals. By increasing the amount of antioxidant enzymes available to your cells, you may be able to prevent or even reverse the effects of oxidative stress that can cause systemic inflammation and fatigue. Oxidative stress as a factor in CFS was studied by researchers using a mouse model that stressed mice via chronic swimming. Mice treated with melatonin — a hormone with antioxidant effects — carvedilol — a medication that is 10 times more potent than vitamin E[xvi] — were observed to have significantly reduced immobilityperiods each day.[xvii] Similar results were observed when mice were administered an oral herbal compound (Withania somnifera (100 mg/kg), quercetin (50 mg/kg) and St. John's wort (10 mg/kg).)[xviii] These treatments further caused a significant reduction in lipid peroxidation, a sign of oxidative stress, and restored the GSH (glutathione) levels decreased by chronic swimming.[xix]

First trial to prove a diet supplement can prevent hereditary cancer Newcastle University (UK), July 25, 2022 A trial in people with high hereditary risk of a wide range of cancers has shown a major preventive effect from resistant starch, found in a wide range of foods such as oats, breakfast cereal, cooked and cooled pasta or rice, peas and beans, and slightly green bananas. An international trial—known as CAPP2—involved almost 1000 patients with Lynch syndrome from around the world, and revealed that a regular dose of resistant starch, also known as fermentable fiber, taken for an average of two years, did not affect cancers in the bowel but did reduce cancers in other parts of the body by more than half. This effect was particularly pronounced for upper gastrointestinal cancers including esophageal, gastric, biliary tract, pancreatic and duodenum cancers. The astonishing effect was seen to last for 10 years after stopping taking the supplement. "We found that resistant starch reduces a range of cancers by over 60%. The effect was most obvious in the upper part of the gut," explained Professor John Mathers, professor of Human Nutrition at Newcastle University. "This is important as cancers of the upper GI tract are difficult to diagnose and often are not caught early on. "Resistant starch can be taken as a powder supplement and is found naturally in peas, beans, oats and other starchy foods. The dose used in the trial is equivalent to eating a daily banana; before they become too ripe and soft, the starch in bananas resists breakdown and reaches the bowel where it can change the type of bacteria that live there. "Resistant starch is a type of carbohydrate that isn't digested in your small intestine; instead it ferments in your large intestine, feeding beneficial gut bacteria—it acts, in effect, like dietary fiber in your digestive system. This type of starch has several health benefits and fewer calories than regular starch. We think that resistant starch may reduce cancer development by changing the bacterial metabolism of bile acids and to reduce those types of bile acids that can damage our DNA and eventually cause cancer. However, this needs further research."   New study finds lowest risk of death was among adults who exercised 150-600 minutes/week Harvard School of Public Health, July 25, 2022 An analysis of more than 100,000 participants over a 30-year follow-up period found that adults who perform two to four times the currently recommended amount of moderate or vigorous physical activity per week have a significantly reduced risk of mortality, according to new research published today in the American Heart Association's journal Circulation. The reduction was 21-23% for people who engaged in two to four times the recommended amount of vigorous physical activity, and 26-31% for people who engaged in two to four times the recommended amount of moderate physical activity each week. In 2018, the United States Department of Health and Human Services' Physical Activity Guidelines for Americans recommended that adults engage in at least 150-300 minutes/week of moderate physical activity or 75-150 minutes/week of vigorous physical activity, or an equivalent combination of both intensities.  The analysis also found: Participants who met the guidelines for vigorous physical activity had an observed 31% lower risk of CVD mortality and 15% lower risk of non-CVD mortality, for an overall 19% lower risk of death from all causes. Participants who met the guidelines for moderate physical activity had an observed 22-25% lower risk of CVD mortality and 19-20% lower risk of non-CVD mortality, for an overall 20-21% lower risk of death from all causes. Participants who performed two to four times above the recommended amount of long-term vigorous physical activity (150-300 min/week) had an observed 27-33% lower risk of CVD mortality and 19% non-CVD mortality, for an overall 21-23% lower risk of death from all causes. Participants who performed two to four times above the recommended amount of moderate physical activity (300-600 min/week) had an observed 28-38% lower risk of CVD mortality and 25-27% non-CVD mortality, for an overall 26-31% lower risk of mortality from all causes. In addition, no harmful cardiovascular health effects were found among the adults who reported engaging in more than four times the recommended minimum activity levels. Previous studies have found evidence that long-term, high-intensity, endurance exercise, such as marathons, triathlons and long-distance bicycle races, may increase the risk of adverse cardiovascular events, including myocardial fibrosis, coronary artery calcification, atrial fibrillation and sudden cardiac death.   Treating dementia with the healing waves of sound Ultrasound applied to the brain could help treat patients with dementia. Tohoku University (Japan), July 20, 2022 Ultrasound waves applied to the whole brain improve cognitive dysfunction in mice with conditions simulating vascular dementia and Alzheimer's disease. The research, conducted by scientists at Tohoku University in Japan, suggests that this type of therapy may also benefit humans. The team, led by cardiologist Hiroaki Shimokawa, found that applying low-intensity pulsed ultrasound (LIPUS) to the whole brain of the mice improved blood vessel formation and nerve cell regeneration without having obvious side effects. "The LIPUS therapy is a non-invasive physiotherapy that could apply to high-risk elderly patients without the need for surgery or anaesthesia, and could be used repeatedly," says Shimokawa. The Tohoku University team found that cognitive impairment markedly improved in mice with conditions similar to vascular dementia and Alzheimer's disease when LIPUS was applied to the whole brain three times a day for 20 minutes each time.    Study: ADHD drugs do not improve cognition in healthy college students University of Rhode Island, July 19, 2022 Contrary to popular belief across college campuses, attention deficit hyperactivity disorder (ADHD) medications may fail to improve cognition in healthy students and actually can impair functioning, according to a study by researchers at the University of Rhode Island and Brown University. Study co-investigators Lisa Weyandt, professor of psychology and a faculty member with URI's George and Anne Ryan Institute for Neuroscience, and Tara White, assistant professor of research in behavioral and social sciences at Brown University, had anticipated different findings. "We hypothesized that Adderall would enhance cognition in the healthy students, but instead, the medication did not improve reading comprehension or fluency, and it impaired working memory," she said. "Not only are they not benefitting from it academically, but it could be negatively affecting their performance." This first-ever multisite pilot study of the impact of so-called "study drugs" on college students who do not have ADHD comes at a time when use of prescription stimulants such as Adderall, Ritalin and Vyvanse is common among young adults who believe the drugs will improve their academic performance.  Results of the study, published in the journal Pharmacy, show that the standard 30 mg dose of Adderall did improve attention and focus -- a typical result from a stimulant -- but that effect failed to translate to better performance on a battery of neurocognitive tasks that measured short-term memory, reading comprehension and fluency. Weyandt has a theory about why working memory would be adversely affected by the medication. Brain scan research shows that a person with ADHD often has less neural activity in the regions of the brain that control executive function -- working memory, attention, self-control. For people with ADHD, Adderall and similar medications increase activity in those regions and appear to normalize functioning. "If your brain is functioning normally in those regions, the medication is unlikely to have a positive effect on cognition and my actually impair cognition. In other words, you need to have a deficit to benefit from the medicine," Weyandt said.         Guanabana: the cancer killer big pharma doesn't want you to know about Northeastern University, July 16, 2022  Guanabana is known by a variety of names -- including soursop, cherimoya, custard apple, Brazilian paw paw and graviola. As far back as the 1970s, the National Cancer Institute (NCI) investigated the merits of guanabana, and discovered the stems and leaves of the tree were successful in destroying cancer cells. "Inexplicably, the results [of the NCI research] were published in an internal report and never released to the public. Since 1976, guanabana has proven to be an immensely potent cancer killer in 20 independent laboratory tests, but as of now, no double-blind clinical trials," reports Christopher Lane, Ph.D., in Psychology Today. Moreover, this study found that a compound derived from the leaves of guanabana was "selectively cytotoxic for the lung (A-549), colon (HT-29), and pancreatic (PACA-2) cell lines with potencies equal to or exceeding those of Adriamycin." And research in the Journal of Natural Products discovered that extracts of guanabana demonstrated pesticidal, antimalarial, antiviral and antimicrobial properties. Likewise, Memorial Sloan Kettering Cancer Center states that guanabana shows anti-inflammatory and anticancer effects in vitro and in vivo. Revered for centuries in South America and Southeast Asia, the bark, leaves, root, seeds and fruit have been used to tame heart disease, asthma, liver issues and arthritis. Guanabana is also helpful for treating sleep disorders, fevers and cough. According to the article, "Guanabana--Medicinal Uses?" extracts of the plant: Attack cancer safely and effectively with an all-natural therapy that does not cause extreme nausea, weight loss and hair loss. Protect the immune system. Boost energy and outlook on life. Effectively target and kill malignant cells in 12 types of cancer -- including colon, breast, prostate, lung and pancreatic cancer. Proved to be up to 10,000 times stronger in slowing the growth of cancer cells than Adriamycin, a commonly used chemotherapeutic drug. Selectively kill only cancer cells, unlike traditional chemotherapy treatments.  *A word of caution: Excessive consumption of guanabana can lead to neuronal dysfunction and degeneration with symptoms similar to Parkinson's disease. Consult with a qualified practitioner before taking guanabana on a daily basis.     High-strength cannabis linked to addiction and mental health problems University of Bath (UK), July 25, 2022 As the strength or potency of cannabis products has increased internationally over the years, so have rates of people being treated for cannabis addiction, say the authors of a new study. Researchers from the Addiction and Mental Health Group at the University of Bath (UK) have systematically analyzed the relationship between the types of cannabis people use and their addiction and mental health problems. Their work draws on 20 studies involving almost 120,000 people. The new study, published in The Lancet Psychiatry, suggests that people who use high-potency cannabis are more likely to experience addiction than those using low-potency products. It also suggests that people using high-potency cannabis are more likely to experience a psychotic disorder, such as schizophrenia. These findings may help to explain why more people have received treatment for cannabis problems over recent years. Data from the European Monitoring Centre for Drugs and Drug Addiction show a 76% increase in people entering treatment for cannabis addiction in the past decade.

提示1.每期为一篇听力题，每篇裁剪为若干片段，每个片段重复四遍。2.可以前两遍盲听理解，后两遍根据文字内容精听。3.根据中英文意思，听不懂的地方多听几遍。原文2018.12六级第一套 recording twoWe've talked recently about the importance of sustainable energy.我们最近谈到了可持续能源的重要性。We've also talked about the different theories on how that can be done.我们还谈到了如何做到这一点的一些不同理论。So far, our discussions have all been theoretical. Now I have a practical question for you all.到目前为止，我们的讨论都是理论上的。现在我有一个实际的问题给大家。Can you run a 140, 000 kilogram train on just the steam generated by solar power?你可以用太阳能产生的蒸汽来运行14万公斤的火车吗？Well, one engineer, Tim Casselman, believes it's possible. And his home city of Sacramento, California should see the technology's first test as part of the upgrading of its rail yard.一位工程师Tim Casselman认为这是可能的。他的家乡加利福尼亚州萨克拉门托市作为其铁路场地升级的一部分，应该见证这项技术的第一次测试。Casselman, who is an inventor and self-proclaimed steam visionary, is campaigning for a new steam train that runs without any fire and could run on an existing 10 kilometer line drawing tourist and perhaps offering city commuters a green alternative to their cars.Casselman是一位发明家，也是一位自称蒸汽梦想家的人，他正在推行一种新式蒸汽列车——无需火烧，并且可以在现有的10公里线路上行驶运载游客，或许也可以为城市上班族提供一种个人汽车的绿色替代品。Casselman wants to build an array of solar magnifying mirrors at one end of the line to collect and focus heat onto water filled tubes.Casselman希望在生产线的一端建造一系列太阳能放大镜，以便将热量聚集到充满水的管子上。This would generate steam that could be used to fill tanks on a small steam train without the use of fire.这将产生蒸汽，可用于在不使用火的情况下，填充在小型蒸汽火车上的储罐上。Supplying power to trains in this way would offer the shortest distance from well to wheels he says with the least amount of energy lost.他说，以这种方式为火车提供动力，将使得气井到车轮的距离最短，从而能量消耗最少。According to Harry Valentijn, a Canadian engineer who is researching modern steam technology, a special tank measuring 2 by 10 meters could store over 750 kilowatt hours of energy as high pressure steam enough to pull a two car train for an hour or so.根据正在研究现代蒸汽技术的加拿大工程师Harry Valentijn所说，一个2米宽10米长的特殊水箱可储存超过750千瓦时的能量，高压蒸汽足以拉动两个车厢的火车一小时左右。Energy to drive a steam locomotive can be stored in other materials besides water.驱动蒸汽机车的能量可以存储在除水之外的其他材料中。for example, a team at Tohoku University in Japan has studied materials that can store large amounts of heat when heated.例如，日本东北大学的一个团队已经研究了可以在加热时储存大量热量的材料。These materials turn from a solid into a liquid absorbing energy as they change phase.这些材料吸收能量时发生相变，从固体变成液体。The liquid is maintained above its melting point until steam is required at which point the liquid is allowed to turn back into a solid releasing its stored energy.液体保持在其熔点以上，到需要蒸汽时，液体可以变回固体释放其储存的能量。Another team at Nagoya University in Japan has tested calcium compound as an energy storage material.日本名古屋大学的另一个团队已经测试了钙化合物作为储能材料。Heating this chemical compound drives off carbon dioxide gas leaving calcium oxide.加热这种化合物会驱除二氧化碳气体，留下氧化钙。The gas can be stored under pressure in a tank to recover the energy. The gas is fed back over the calcium oxide.气体可以在压力下储存在储罐中以回收能量。气体被氧化钙反作用。In theory says Valentijn this can create a high enough temperature to generate superheated steam.Valentjn说，理论上这个过程可以产生足够高的温度来产生过热蒸汽。问题：19:A) The engineering problems with solar power.B) The generation of steam with the latest technology.C) The importance of exploring new energy sources.D) The theoretical aspects of sustainable energy.20:A) The engineering problems with solar power.B) The generation of steam with the latest technology.C) The importance of exploring new energy sources.D) The theoretical aspects of sustainable energy.21:A) Build a thank for keeping calcium oxide.B) Find a new material for storing energy.C) Recover super-heated steam.D) Collect carbon dioxide gas.

News: New prehistoric human unknown to science discovered in Israel | The Jerusalem Post (01:20) A new type of early human previously not known to scientists has been discovered in Israel, Tel Aviv University and Hebrew University researchers announced Thursday, July 14th. They believe this new “Homo” species intermarried with Homo sapiens and was an ancestor of the Neanderthals. The dig site, Nesher Ramla, a few kilometers from the modern-day city, was probably close to a water reservoir where early humans could hunt animals.Filled with many animal bones, stone tools for making fire and butchering Prof. Israel Hershkovitz talked on the dig site:“We know that modern humans – or Homo sapiens – arrived in this area some 200,000 years ago … When we started excavating and examining the different archaeological layers, we found that they dated back between 140,000 and 120,000 years ago, so we expected to find remains of Homo sapiens. We did not realize that another form of human was living alongside them.” The researchers believe that the newly discovered human type, which they named after the site, lived in the region hundreds of thousands of years ago and at least until 130,000 years ago. The findings may radically change what researchers have so far believed about how ancient populations evolved and interacted.Especially how sapiens and Neanderthal, other ancient human types, related to each other. Researchers believe the Nesher Ramla was an ancestor of the Neanderthals and other archaic Asian populations.Thought Neanderthals arrived in what is now Israel 70,000 to 50,000 years ago from Europe, but here they found a human species 130,000 years old. Some features of the remains, like the teeth and the jaws, were more similar to Neanderthal species, while the skulls resembled the Homo type. According to Hershkovitz, Nesher Ramla Homo and Homo sapiens not only coexisted peacefully and exchanged technology, but also produced offspring.“In Europe, the story was very different because when modern humans arrived there around 45,000 years ago, they completely eliminated the local Neanderthals. This did not happen here” In the past, geneticists had already suggested that an unknown population represented the missing link between sapiens and Neanderthal.The Nesher Ramla population could represent the answer.   Prunes can restore bone loss, research finds | Brighter Side News (06:58) New research provides evidence that prunes are a prebiotic food that reverses bone loss in mice.Findings show the ​​carbohydrates and polyphenols in prunes act as prebiotics and help restore bone health. Principal Investigator, Brenda Smith, PhD explains:“Both the carbohydrate component and the polyphenols within the prunes altered the gut microbiota and were associated with positive effects on bone, namely restoring bone. By definition, prebiotics are substrates that alter the composition or activity of the microbiota and confer benefits to the health of the individual” Researchers isolated the polyphenol (PP) compounds as well as the carbohydrates (CHO) from prunes and fed them to two separate groups of estrogen-deficient, female mice with substantial bone loss for 5- and 10-week durations. In the study they had 4 groups of mice with different diets:Receiving the polyphenol (PP) compounds and carbohydrates directly Whole prunes Prune crude extract with both PP and CHO prune components Control (i.e. no prunes or extract) Compared to the mice who did not consume any prune or prune component, those who consumed isolated CHO, isolated PP, prune crude extract, or whole prunes experienced restored bone previously lost. Showed a significant increase in short chain fatty acid (SCFA) production in their guts Favorable changes to their gut microbiota.  Researchers saw increases in SCFAs n-butyrate and propionate, which are thought to be most effective at preventing bone loss by suppressing biomarkers associated with bone breakdown. Smith suggests the findings make a strong case for consuming whole prunes “because you're getting some of the benefit from the carbohydrate in the short term, and the long-term benefit from the polyphenols.”Smith also noted that the vitamins, minerals, and plant compounds in prunes may contribute to the bone and the gut benefits.  This research gets us closer to understanding the unique attributes of prunes while underscoring the importance of eating the fruit in its entirety.    Scientists create a nearly invisible solar cell with up to 79% transparency | Interesting Engineering (11:07) A team of scientists from the Tohoku University in Japan has created a near-invisible solar cell using indium tin oxide (ITO) as a transparent electrode and tungsten disulfide (WS2) as a photoactive layer.Potential to achieve a transparency of 79 percent This type of PV device is known as the Schottky junction solar cell.An interface put between a metal and a semiconductor provides the band required for charge separation.  The suggested device and ideal band structure separate the photogenerated electron-hole pairs by a difference in the work function between one of the electrodes and the semiconductor.  WS2 is a member of the transition metal dichalcogenide (TMD) family of materials, which the scientists claim are perfect for near-invisible solar cells due to their acceptable band gaps in the visible light range and greatest absorption coefficient per thickness.  The contact barrier between WS2 and ITO was adjusted by coating various thin metals on top of ITO material and introducing a thin layer of WO3 (Tungsten trioxide) between ITO and the monolayer WS2.Result: the Schottky barrier height increased dramatically. Potential for increasing the efficiency of charge carrier separation in this Schottky-type solar cell. The power conversion efficiency of the solar cell with the optimized electrode (WO3/Mx/ITO) was more than 1,000 times greater than that of a device employing a regular ITO electrode. With the aid of studies like this one, we may eventually develop transparent solar panels, which would have far-reaching ramifications.There are reportedly five to seven billion square meters of glass surfaces in the United States, from phone screens to skyscrapers.    Drug Treatment for Cataracts Might Soon Become a Reality | SciTechDaily (16:11) According to the World Health Organization, cataracts are one of the leading causes of blindness throughout the world. Cataracts account for more than 51 percent of blindness throughout the world. In the United States alone, over 24.4 million people over the age of 40 have been affected by cataracts. A cataract is a clouding of the eye lens that develops over time and compromises the quality of vision. Caused by a disorder of the proteins in the lens that leads to clumps of protein accumulating that scatter light and substantially limit transmission to the retina. Currently, cataracts can only be cured with surgery. However, a groundbreaking new treatment for cataracts has had incredibly positive laboratory test results suggesting that the affliction might soon be able to be treated with drugs. A team of international scientists at Anglia Ruskin University, have been carrying out advanced optical tests on an oxysterol compound that had been proposed as an anti-cataract drug. In laboratory trials, treatment with the oxysterol compound VP1-001 showed an improvement in refractive index profiles – a key optical parameter that is needed to maintain high focusing capacity – in 61% of lenses.Meaning that the protein organization of the lens is being restored, resulting in the lens being better able to focus.  Professor Barbara Pierscionek, lead researcher, stated:“This study has shown the positive effects of a compound that had been proposed as an anti-cataract drug but never before tested on the optics of the lens. It is the first research of this kind in the world.”  She continues mentioning this compound could only affect a certain kind of cataracts:“Improvements occurred in some types of cataracts but not in all indicating that this may be a treatment for specific cataracts. This suggests distinctions may need to be made between cataract types when developing anti-cataract medications. It is a significant step forward towards treating this extremely common condition with drugs rather than surgery.”   Cancer drug triggers remarkable recovery from spinal cord injury in mice | New Atlas (21:08) A drug under investigation as a cancer treatment has shown exciting promise in a rather different branch of medical research, with scientists demonstrating how it can promote nerve repair following spinal injury.  The drug acts on a DNA damage response mechanism and triggers a "remarkable" recovery in mice with injured spinal cords. The DNA Damage Response system, which swings into action in response to DNA damage caused by several common cancers, and also in response to spinal cord injury. Led by scientists at the University of Birmingham, the research focused on an experimental drug called AZD1390. Under investigation as a cancer therapy due its potential to make tumor cells more sensitive to radiation treatment. The authors of the new study hypothesize that the activation of this DNA Damage Response system may slow or prevent recovery from spinal cord injury, by hampering nerve repair.The thinking was that by using AZD1390 to inhibit the ATM signaling pathway, they could clear the way for the growth of new nerve cells. In mice with spinal cord injuries, oral administration of AZD1390 was also shown to significantly suppress the pathway. Further, it promoted nerve regeneration beyond the site of the injury, and enhanced the capacity of these nerves to relay electrical signals Study author Professor Zubair Ahmed, stated:“This is an exciting time in spinal cord injury research with several different investigational drugs being identified as potential therapies for spinal cord injury … We are particularly excited about AZD1390 which can be taken orally and reaches the site of injury in sufficient quantities to promote nerve regeneration and restore lost function. Our findings show a remarkable recovery of sensory and motor functions, and AZD1390-treated animals being indistinguishable from uninjured animals within four weeks of injury." Such a rapid and effective recovery, making injured mice appear much like uninjured mice in 4 weeks, positions AZD1390 as an exciting potential treatment for a condition that has no cure.  Though just an initial study, the fact that it centers on a drug already under investigation may also shorten its path to clinical use.

In this episode, Alan Cash talks about oxaloacetate and the beginning of his journey in developing it as a nutritional supplement. He shares the ongoing research on oxaloacetate's benefits, especially for patients suffering from brain damage. He also dives into oxaloacetate's ability to increase muscle use before fatigue and reduce anxiety and depression levels in women experiencing PMS. If you want to learn more about oxaloacetate's many benefits and applications, then this episode is for you! Here are three reasons why you should listen to this episode: Learn what oxaloacetate is and how it can help slow the biological effects of ageing. Discover the numerous potential health benefits of oxaloacetate. Get to know Alan's journey in developing and manufacturing oxaloacetate as a nutritional supplement. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the world's greatest science and health minds? Then reach out to us at support@lisatamati.com, and we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey of how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions worldwide, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Quercetin and Trimethylglycine by NMN Bio Benagene, an oxaloacetate supplement by benaGene Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health to live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. ​100% vegan and non-GMO. ​The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! ​No other form of protein comes close to PerfectAminos Ketone Products by Keto-Pro Exogenous Ketones developed by Nutritionist and Body Building champion Richard Smith. Keto-Pro BHB Exogenous Ketones –  250g   MORE BHB per gram than other MARKET LEADERS. During In-house testing, Keto-Pro BHB raised ketones quicker, higher and for longer than other market leaders. Ketones My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [09:36] How Alan Found Out About Oxaloacetate Alan got sick and needed to undergo brain surgery. He found out that his pain and illness were related to ageing. As Alan researched more about ageing, he discovered calorie restriction, wherein organisms tend to live longer when they eat less. Increasing the ratio of Nicotinamide Adenine Dinucleotide (NAD) to NADH helps fight off ageing. Alan started looking into biomechanical pathways and found that oxaloacetate that can change the ratio of NAD from NADH to 900% in just two minutes. He started testing oxaloacetate using worms and realised that the activated pathway was the same as calorie restriction. [21:53] What is Oxaloacetate? Oxaloacetate is a naturally occurring molecule in our bodies during metabolism. It exists in every cell of the body and, therefore, is non-toxic. Oxaloacetate is considered a hot molecule right now, given how it can help moderate metabolism on a cell-by-cell basis. Increasing oxaloacetate affects metabolism, which is vital to some people. [25:38] Patenting Oxaloacetate  Tohoku University in Sendai, Japan, conducted research in the 1960s which found how oxaloacetate reduced fasting glucose levels in type one and type two diabetics.  At first, Alan ran into the problem of being unable to get a patent for oxaloacetate, a naturally occurring compound in the human body. He persevered and eventually was able to own patent rights based on how oxaloacetate can maintain its stable form of enol-oxaloacetate.  After rigorous testing, their products now have a shelf life of two to three years or more. [31:00] Oxaloacetate and the Warburg Effect Oxaloacetate is a potential drug for brain cancer such as glioblastoma. It also has the potential to reverse the Warburg effect, in which fermented glucose turns into lactate that a tumour feeds off. Giving Oxaloacetate to cancer cells changes the cancer metabolism cell by cell. There's a specific dosage where cancer cells stop reproducing. [38:03] Oxaloacetate and Glutamate Glutamate is a compound that fires off the neutrons in the brain. Excessive glutamate excites the neurons until they die, a process known as excitotoxicity. Many studies describe how we may reduce the risk of excitotoxicity.  Alan is looking into cognition through clinical trials with Alzheimer's disease patients. The study showed how oxaloacetate reduced glutamate levels. In the same clinical trial, they also found how oxaloacetate increased the amount of glucose the brain can take in. The brain can take in more glucose due to the signalling protein PGC-1 Alpha enabling the production of more mitochondria. [38:03] Oxaloacetate Can Improve Muscle Use Oxaloacetate also improves muscle use by 10% more before it goes into fatigue. 10% is a significant improvement for both top-end athletes and daily living. Alan has done a clinical trial that showed a 25% to 30% drop in fatigue levels within six weeks, even for people with chronic fatigue syndrome or ME/CFS for up to 30 years. NF-κB turns on genes that release a cytokine storm, which at high levels can lead to chronic inflammation seen in arthritis or long COVID patients. Animal models show that oxaloacetate led to a reduction of NF-κB's translocation to the nucleus by 70%, which turns off the cytokine storm.  People experiencing chronic fatigue can benefit from oxaloacetate's mechanism of producing new mitochondria.  [51:34] Increase Focus and Attention Using Oxaloacetate In animal models, oxaloacetate turns on the mechanism to increase the number of neurons in the brain and increase the length of the axons, the little tendrils that connect neurons. Alan did a critical trial on the effect of oxaloacetate on premenstrual syndrome (PMS), wherein he found a 50% drop in anxiety, depression and suicide ideation. Drugs have an immediate pharmacological effect. Another is the genomic effect with a cumulative property that takes about a month or more to see. Even after getting better from your illnesses, keep the ball rolling and don't stop intaking your medicine and supplements. 7 Powerful Quotes ‘We could see when we gave the oxaloacetate to them if they live longer, or if they didn't, so we could eliminate what were the critical genes. And, we were able to follow along with a pathway, and it turned out to be the exact same pathway as calorie restriction, which is really exciting.' ‘First of all, is oxaloacetate toxic? Well, it turns out it's a human molecule. It's in metabolism. It's in practically every cell of your body.' ‘Experiment and see what works and understanding some of these mechanisms is really important because then we can actually start to connect the dots of cells.' ‘The reality is most people are not going to have the perfect diet, not going to be in a perfect environment, can't maybe even afford to have great food, or organic food, or all of these things that restrict us from having the ideal.' ‘None of us are going to know what's around the corner for us but, if we can be in that preventative space and be understanding this more and more, then that is to me the most fascinating conversation we can have.' ‘What happens then is that they stop all their protocol, and the thing that they were doing and, “Now I'm fixed. I don't need it anymore.” And I'm like, “Hang on a minute, you don't drop the ball now. You're already underway. You got to stay underway. You got to keep it going.”' ‘You want that cumulative, and those epigenetic changes, and those long term changes.' Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Studies on Anti-diabetic Effect of Sodium Oxalcacetate Get benaGene Capsules containing oxaloacetate  Get TMG (Trimethylglycine) as the ultimate anti-aging combination with NMN  PerfectAmino Tablets by Bodyhealth Keto-Pro's D-BHB Exogenous Ketones - Chocolate Flavour Keto-Pro's Keto Bar - Chocolate Almond Brownie Colloidal Health's Colloidal Silver Black Cumin Seed Oil Connect with Alan Cash: LinkedIn About Alan Alan Cash is a physicist, biologist and geologist. He's also a professional entrepreneur and the CEO and Founder of Terra Biological LLC and MetVital, Inc.  Alan is also the clinical trials supervisor and medical researcher. He's currently pursuing the advancement and development of nutritional supplements containing oxaloacetate, which is known as a caloric-restriction mimetic compound. His research has brought profound breakthroughs addressing cognitive decline and anti-aging. If you want to reach out, you may connect with Alan via LinkedIn. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa

In this podcast, Dr Nicole Brown talks to Dr Hakan Ergül about Practice As Research.Dr Hakan Ergül is a Lecturer in Media Studies in the UCL Knowledge Lab of the Department of Culture, Communication & Media at IOE, UCL's Faculty of Education and Society. Hakan received his PhD in 2006 from the Graduate School of International Cultural Studies, Tohoku University, Japan, with my 5-years ethnographic inquiry on Japanese television production. Hakan's short stories have appeared in a number of literary journals, and he is the author of Dedicated to Chrysanthemum (in TR: Krizanteme Adanmis, 2003) and Where Do the Noises Come From?  (TR: Sesler Nereden Geliyor? 2009), anthology of short stories. His most recent books include Popularizing Japanese TV (author, Routledge 2019) and Universities in the Neoliberal Era (co-editor, Palgrave 2017).Hakan's current research examines the role of traditional and digital communication technologies in everyday life of vulnerable groups, including children, refugees, and urban poor from ethnographic perspective.   

All eyes are on Glasgow as COP26 heads towards its last days of discussion. REEI's Zhao Ang and Lin Jiaqiao starts the episode by summarizing key accomplishments and progress from COP26 this week. Following our last episode, where we interviewed Prof. Asuka from Tohoku University in Japan discussing issues related to COP and views on NDCs, this week we'll interview Mr. Lee Jieon  (climate and energy coordinator with Korea Federation for Environmental Movements, KFEM), to discuss about the South Korean's energy and climate policy in the context of COP26. Mr. Lee shared his views on Korea's commitment at COP26, local media reactions to South Korea's performance at COP26, and his thoughts on South Korea's progress in popular topics such as coal phase-out, coal financing and energy transition.  If you enjoy contents like this, please subscribe to our channel!

In this Asia Insight podcast, Tom Lutken speaks with T.H. Schee of Open Knowledge Taiwan and Takako Izumi of Tohoku University about the disaster management lessons learned from the 2011 Tohoku earthquake and tsunami. With changes brought about by technology and global warming, alongside the ongoing impacts of a global pandemic, both experts weigh in on how our best practices for dealing with disasters can be informed by the past to better prepare for an uncertain future.

As COP 26 is ongoing in Glasgow, many countries have updated their NDCs. Are these NDCs ambitious enough to achieve the 1.5℃ target? What outcome are we expecting from COP 26? In this episode, Lin from REEI will talk with Prof. Jusen Asuka from Tohoku University about their views on NDCs, then moveon to topics such as power shortages, role of coal and carbon border adjustment measures. Prof. Asuka supports for more renewables and thinks Japan needs a quicker coal phase-out, that is technically possible and economically viable.Japan needs 'real green' measures in energy transition at home and abroad. REEI is holding a virtual exhibit at the COP26 Platform, which showcases our efforts in improving the understanding of climate change issues and prompting multi-stakeholders participation in climate action. Our virtual exhibit link: https://lnkd.in/g-E2zXd3 *NOTE: Only registered at Online Registration System (ORS) can have access to the COP26 Platform.

Pada episode ini kami kedatangan teman seangkatan kami yang akan menceritakan kuliahnya di Computer dan Mathematical Science di Tohoku University, kisah seru kuliah (baca: les privat) Struktur Aljabar (mulai dari 26:56) dan cerita gimana caranya biar bisa lulus 3,5 tahun di jurusan Matematika ITB (mulai dari 51:48) Gambar background dari Vasily Koloda (Unsplash)

When catastrophes like a pandemic strike, how do we make sure societies learn – and implement – lessons from disaster? We talk to three researchers coming at this question in different ways. First, a story from northern Australia about how Indigenous knowledge that can help to prevent natural disasters has been with us for thousands of years. We speak to Kamaljit Sangha, senior ecological economist at the Darwin Centre for Bushfire Research at Charles Darwin University in northern Australia.Second, what happens when a country with a long history of preparing for disasters, faces something it didn't predict. With Elizabeth Maly, associate professor of international research at the Institute of Disaster Science at Japan's Tohoku University. And third, use the recovery from a disaster like the pandemic as a catalyst for change. We speak to Ian Goldin, professor of globalisation and development at the University of Oxford in the UK. And Julius Maina, East Africa editor at The Conversation in Nairobi, recommends some analysis of this week's crucial election in Ethiopia. The Conversation Weekly is produced by Mend Mariwany and Gemma Ware, with sound design by Eloise Stevens. Our theme music is by Neeta Sarl. You can find us on Twitter @TC_Audio, on Instagram at theconversationdotcom or via email on podcast@theconversation.com. You can also sign up to The Conversation's free daily email here. Full credits for this article available here. The stories in this episode are tied to two series on The Conversation. Resilient recovery looks at how to recover from the pandemic in a way that makes societies more resilient and able to deal with future challenges. It's supported by a grant from PreventionWeb, a platform from the UN Office for Disaster Risk Reduction. And a second series called Disaster and Resilience focused on the nexus between disaster, disadvantage and resilience, supported by a grant form the Paul Ramsay foundation. Further reading:Indigenous expertise is reducing bushfires in northern Australia. It's time to consider similar approaches for other disasters, by Kamaljit K Sangha, Charles Darwin University; Andrew Edwards, Charles Darwin University, and Willie Rioli Sr, Indigenous KnowledgeTsunamis, earthquakes, nuclear meltdowns and COVID-19 – what Japan has and hasn't learned from centuries of disaster, by Elizabeth Maly, Tohoku UniversityCOVID-19 has shown that following the same road will lead the world over a precipice, by Ian Goldin, University of OxfordRecovery: a series from The Anthill podcast. Part 1: How Europe recovered from the Black Death, featuring Adrian Bell, University of Reading, Eleanor Russell, University of Cambridge and Mark Bailey, University of East AngliaMore than a decade after the Black Saturday fires, it's time we got serious about long-term disaster recovery planningLisa Gibbs, The University of MelbourneLearning from COVID: how to improve future supplies of medical equipment and vaccines, by Liz Breen, University of BradfordWhat we can learn about risk from the COVID experience, by Geoff Mulgan, UCL See acast.com/privacy for privacy and opt-out information.

This week's cover paper of Oncotarget (Volume 12, Issue 13) is entitled, "Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target," by researchers from Kindai University, Higashiosaka-Shi, Osaka, Japan; Tohoku University, Sendai-Shi, Miyagi, Japan; Tokyo University of Science, Noda-shi, Chiba, Japan; Hyogo University of Health Sciences, Kobe-Shi, Hyogo, Japan. Abstract: L-type amino acid transporter 1 (LAT1)/SLC7A5 is the first identified CD98 light chain disulfide linked to the CD98 heavy chain (CD98hc/SLC3A2). LAT1 transports large neutral amino acids, including leucine, which activates mTOR, and is highly expressed in human cancers. We investigated the oncogenicity of human LAT1 introduced to NIH/3T3 cells by retrovirus infection. NIH/3T3 cell lines stably expressing human native (164C) or mutant (164S) LAT1 (naLAT1/3T3 or muLAT1/3T3, respectively) were established. We confirmed that endogenous mouse CD98hc forms a disulfide bond with exogenous human LAT1 in naLAT1/3T3, but not in muLAT1/3T3. Endogenous mouse CD98hc mRNA increased in both naNIH/3T3 and muLAT1/3T3, and a similar amount of exogenous human LAT1 protein was detected in both cell lines. Furthermore, naLAT1/3T3 and muLAT1/3T3 cell lines were evaluated for cell growth-related phenotypes (phosphorylation of ERK, cell-cycle progression) and cell malignancy-related phenotypes (anchorage-independent cell growth, tumor formation in nude mice). naLAT1/3T3 had stronger growth- and malignancy- related phenotypes than NIH/3T3 and muLAT1/3T3, suggesting the oncogenicity of native LAT1 through its interaction with CD98hc. Anti-LAT1 monoclonal antibodies significantly inhibited in vitro cell proliferation and in vivo tumor growth of naLAT1/3T3 cells in nude mice, demonstrating LAT1 to be a promising anti-cancer target. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27981 DOI - https://doi.org/10.18632/oncotarget.27981 Full text - https://www.oncotarget.com/article/27981/text/ Correspondence to - Takashi Masuko - masuko@phar.kindai.ac.jp Keywords - CD98, LAT1, monoclonal antibody, NIH/3T3, oncogenicity About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Leslie and Sachiko are joined by a special guest, Dr. David N. Nguyen, an Associate Professor by Special Appointment at the International Research Institute of Disaster Science of Tohoku University, and the Japanese National Research Institute for Earth Science and Disaster Prevention. Dr. Nguyen was featured in Trishit's article, “A Decade and a Pandemic - The Recovery of Fukushima.” In light of the 10th anniversary of the 2011 Tohoku earthquake, Leslie and Sachiko ask Dr. Nguyen how Fukushima has changed, 10 years after the tragic event on March 11, 2011. Read more about Trishit's article and Dr. Nguyen's comments here. Follow Voice Up Japan on Twitter, Facebook, and Instagram for more updates.

This episode is our first to highlight a Nutrition Review's supplement. Dr. Teruo Miyazawa was the special guest editor for the proceeding of the 8th International Conference on Nutrition and Aging. Dr. Miyazawa is a Professor at Tohoku University and he provides how advances in nutritional sciences are helping extend healthy lifespans. The conference supported by ILSI Japan also provides important insight on why Japan is the country with the greatest life expectancy in the world.

Timothy Langley has been in Japan for over 40 years and has an intriguing career in American and Japanese public affairs. Mr. Langley originally grew up in Okinawa where his father's military post was stationed. After graduating from the University of Georgia, Mr. Langley taught English and played for the Santa Monica Rugby Club. He set his path to become a lawyer through the Monbusho scholarship and attended Tohoku University to study law but was rejected from taking the bar exam as a foreigner since it had “never been done.” Unable to sit for the bar, Mr. Langley landed a job at the Japanese National Parliament after writing to a prominent Japanese politician and sending his resumes. Since this was the first time a foreigner was working inside the Japanese government, Mr. Langley was featured in the media within and outside of Japan including the American CBS show, 60 minutes.   Mr. Langley eventually became an official lawyer after completing a law program at Georgetown. After working in Atlanta for a few years at a law firm, Mr. Langley was hired as an attorney for a manufacturing company in Kyoto to deal with a trade issue they were facing with the US government. Mr. Langley calls this experience working for a traditional Japanese company to be “a valuable experience in seeing how the Japanese work…how decisions are being made.” He also notes the difference in leadership that he observed: “basically since it's a Japanese company, you're going to be there until you die. So that leadership and that aspiration that you might have to be a leader is applied very differently than it might be in a competitive environment, such as in the United States…and [Japanese] people [are] very risk averse as, as people know. And they're punctual, they get the job done, but they follow the manual.   Mr. Langley then became the representative for the Commonwealth of Kentucky in Japan where he served for two years and gained some early leadership experience managing several staff. He then became General Counsel for Apple for four years where Mr. Langley essentially established the legal division from scratch. Since Apple was a growing company at the time, Mr. Langley recalls many challenges, including hiring the right staff and gaining commitment. Mr. Langley then transitioned into Amway for a brief period, before returning to Denver, Colorado with his family to start a law firm. He was not away from Japan for too long after being approached by General Motors to become their General Counsel and Director of Government Affairs in Asia although his term was cut short due to the 9-11 attacks.   But this time, Mr. Langley was committed to staying in Japan. Realizing his value add as General Counsel, having represented global companies like General Motors and Apple, Mr. Langley started Langley Esquire, a public affairs consultancy where he is the President and Representative Director. He describes his earlier challenges on recruitment, including convincing his sons to join the organization. Mr. Langley also highlights the importance of building trust and avoiding a breach of trust to maintain good relations, which he calls “an asset that can be transitioned from generation to generation.”   To new leaders coming to Japan, Mr. Langley advises to have language familiarity, carefully observe others and ask questions to pick up on social cues that will help with decision-making. He adds that holding back and pausing in conversations is also a great way to communicate, claiming that in Japan, the “things that are being left unsaid carry as much weight as what [people] are verbally saying.”

What role can hydrogen fuel cell electric vehicles(FCEV) play in decarbonizing road transport sector from now to 2050? If so, how? Which country is the leader in the development of FCEV?What is China's strategy in this field? What obstacles does FCEV have to overcome in order to make meaningful contributions to achieving carbon neutrality in the long run among those potential leaders of FCEV? In this episode, REEI’s Ang Zhao has a discussion with Dr. Greg Trencher from Tohoku University, Japan.

Hey Japanpreneurs, this episode of Small Business Japan is a unique blend of entrepreneurship, traditional Japanese culture and history, rural tourism, and self-development and spirituality. Tim Bunting is a certified Yamabushi with more than a decade of experience in Yamagata living near the Dewa Sanzan. Originally from New Zealand, the self-professed nature lover spent many of his formative years in the great outdoors, and truly feels at home amongst the vast forests, sprawling rice fields, and mountains of Yamagata Prefecture. For Tim, the Dewa Sanzan holds a special importance as a place to get away from the real world, and back to a simpler time, that he believes is something that could benefit people all over the world. Tim’s interests include Japanese history and culture (he is the curator of dewasanzan.com), coffee, photography, music, and sports such as cricket and rugby. He is also an ASSISTANT PROFESSOR at Tohoku University of Community Service and Science and a FREELANCE TRANSLATOR AND INTERPRETER. Tim does have a stable job at a local university but he is pursuing a creative entrepreneurial side job that overlaps tourism and spirituality. Nestled in the Tohoku Region between inland Yamagata Prefecture and the Shonai coast on the Sea of Japan, the Dewa Sanzan is the collective name for the three sacred mountains of Dewa;Mt. Haguro, Mt. Gassan, and Mt. Yudono, the location for the pilgrimage of rebirth for over 1400 years. Him and his business partner had an interest in promoting the Northern area and spreading the word of the uniqueness and beauty of their rural area. They did this through Yamabushi and pilgrimages to the mountains...

Today's guest is Pelonomi Moiloa. Pelonomi has 3 Engineering degrees including a Master’s degree in Biomedical Engineering from Tohoku University in Japan. Pelonomi is currently working as a data scientist on data analytics solutions. Tune in to hear her journey on navigating the tech world in South Africa. Let us know what you think of this episode by sharing it on Instagram or Twitter and tagging us @shebrigade Please also subscribe, follow and leave us a review on whichever platform you're listening on. --- Send in a voice message: https://anchor.fm/shebrigade/message

We have our very first guest on this episode, Arie from Indonesia! This episode is a continuation from the very first episode to compare what Arie and her family went through when she lived in Japan from 2014-2019. Comparing to what Abhi went through 25 years ago, do you think things have changed in Japan where it is more accepting today, compared to when Abhi was living? Let's find out through Arie's experiences.Tohoku University, as mentioned in this episode, is a great place for foreigners to get a higher degree since many programs are offered in English, variety of scholarship programs, and many more that make foreigners have a great experiences. Here are the links for anyone who are interested in  studying in Japan and want to look into Tohoku University:AdmissionCourses Taught in EnglishIf you have any questions for Arie or about Tohoku University,  please leave a comment on the "Stand Out But Please Fit" social media pages!InstagramTwitter

Science is a global endeavor—especially in today's world. Tohoku University assistant professor Theresa (Tessa) Davey discusses the importance of intercultural collaboration, her work using the CALPHAD method, and why she sees diversity and equity as keys to advancing science in the future.View the transcript for this episode here.About the guestTessa Davey is assistant professor at Tohoku University in Japan. As a researcher in Tohoku's Fracture and Reliability Research Institute, Davey specializes in using the CALPHAD method, a semi-empirical approach for modeling thermodynamic properties and phase diagrams of multicomponent systems. Davey served as the first international chair of ACerS President's Council of Student Advisors, and she is passionate about promoting intercultural collaboration, diversity, and equity in STEM fields.About ACerSFounded in 1898, The American Ceramic Society is the leading professional membership organization for ceramic and materials scientists, engineers, researchers, manufacturers, plant personnel, educators, and students.

Cheryl Ames Smithsonian's National Museum research associate and associate professor at Tohoku University joins Sean on the show.    

Sabayan tayo sa outer space! Kasabay si Paolo Espiritu, Philippine scientist na nag-training ng MS Aerospace Engineering sa Tohoku University, Japan. Intellectwalwal conversation on how science & technology sounds lofty, pero dapat grounded din ang paggamit dito sa Pilipinas. Also, how we should have the "Maker's mindset." Sabayan na! See acast.com/privacy for privacy and opt-out information.

I've met Hikaru Hie at a mini-conference of Applied Improvisation Network in Manila in the Philippines during the Manila Improv Festival in 2019. Right away, I was struck by her positivity and how she could connect with everyone so easily. Truth is, Hikaru is genuine in her interactions with people and that makes people want to gather around her and listen to her wisdom drinking tea discussing about existential questions with a good dose of respect and fun. The day we met I've visited the school where she works as a Associate Professor and Freshmen Program Director of Tohoku University of Art and Design. I'm forever thankful I've had the chance to interview this inspiring woman who improves the world of Education by saying yes. You curious? : To learn more about her work as a practitioner with the AIN follow this link : SAYING YES! To learn about the Kyoto University of The Arts. To learn about the concept of Yes and in Improvisation: Second city Improv (Base in Chicago, provide training and other wonderful delicacies) ImproWiki (Bank of exercises, games and activities for anyone who's interested in Improv) --- Send in a voice message: https://anchor.fm/laurence-couture/message

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University's Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan's modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University's Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University's Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan's modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University's Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University’s Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan’s modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University’s Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University’s Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan’s modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University’s Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University’s Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan’s modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University’s Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University’s Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan’s modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University’s Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University’s Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of... Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/japanese-studies

In Darwin, Dharma, and the Divine. Evolutionary Theory and Religion in Modern Japan (University of Hawaii Press, 2017), G. Clinton Godart (Associate Professor at Tohoku University’s Department of Global Japanese Studies) brings to life more than a century of ideas by examining how and why Japanese intellectuals, religious thinkers of different faiths, philosophers, biologists, journalists, activists, and ideologues engaged with evolutionary theory and religion. How did Japanese religiously think about evolution? What were their main concerns? Did they reject evolution on religious grounds, or - as was more often the case - how did they combine evolutionary theory with their religious beliefs? These are some of the questions the book tries to answer, in a tour de force that takes the reader from the Meiji Restoration to the contemporary period. And in doing so, the book makes a significant contribution to two of the most debated topics in the history of evolutionary theory: religion and the political legacy of evolution. Since the introduction of evolutionary theory in the nineteenth century, Japanese intellectuals - including Buddhist, Shinto, Confucian, and Christian thinkers - struggled to formulate a meaningful worldview after Darwin. They often had opposing agendas, and so the debate was quite heated and long-lived: as Godart argues in his book, it took a hundred years of appropriating, translating, thinking, and debating to reconsider the natural world and the relation between nature, science, and the sacred in light of evolutionary theory. Eventually, the drive to find goodness and the divine within nature and evolution shaped much of Japan’s modern intellectual history and changed Japanese understandings of nature, society, and the sacred. Roman Paşca is Assistant Professor at Kyoto University’s Graduate School of Letters, Department of Japanese Philosophy. Learn more about your ad choices. Visit megaphone.fm/adchoices

Los mexicanos comemos volcanes es la frase que me ha hecho reír y apreciar la narrativa de un científico como el Dr. Hugo Delgado Granados, investigador de la UNAM. Es Investigador de Carrera Titular C, del Instituto de Geofísica. En esta plática el aborda como llegó a trabajar con el campo volcánico Tequila, nos comenta de los tiempos de actividad volcánica en esta región y de sus magmas que dieron lugar a los vidrios de obsidiana. Una de las acepciones de la palabra Tequila es lugar donde se corta y sabemos que la obsidiana servía para cortar. ¡No se pierdan esta y otras clases de vulcanología en mas episodios de agavecultura! Comparto parte de su biografía en inglés para que lo conozcan. I studied in the Faculty of Engineering of the National Autonomous University of Mexico (UNAM) between 1976 and 1980, obtaining the degree of Engineering Geologist. I studied the courses of Master and Doctor of Sciences at the Faculty of Science of Tohoku University of Japan between 1987 and 1992. I obtained the MSc degree studying volcanic rocks of the Ou Mountains of northeast Japan documenting the existence of a 7 million years old caldera that had not been reported to that date. I obtained the DSc degree in the area of geology studying volcano-tectonics of the Chapala region, Jalisco (Mexico). My academic career has always been linked to UNAM. Since 1983 I teach Geodynamics as professor in the Faculty of Engineering. I developed glaciological work in the Institute of Geography from 1983 to 1984 together with José I. Lugo Hubp. I collaborated with Jaime H. Urrutia Fucugauchi in the Laboratory of Paleomagnetism and Nuclear Geophysics from 1984 to 1986, performing studies of paleomagnetism in volcanic rocks. Since 1991, I am a researcher of the Department of Volcanology of the Institute of Geophysics, where I also teach graduate courses in Earth Sciences. Since 1985 I act as the Mexican correspondent of the World Glacier Monitoring Service of the International Association of Hydrological Sciences of the UNESCO. #agavecultura #agavelessons #agave #mezcal #mezcalovers #maguey #agavelovers #bacanora #raicilla #sotol #comiteco #agaveducation #agaveducators #agaveSpirits #agaveSyrup #AnaValenzuelaZ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/ana-g-valenzuela-zapata/message

Our guest today truly pushes the boundary of architectural design, to infinity and beyond. We are super stoked to have Hatem Al Khafaji join us today! With a relatively ,conventional foundation to his architectural journey, Hatem completed his undergrad in architectural engineering from the University of Sharjah. Whilst in professional practice, Hatem maintained a healthy connection to academic research. He spent 4 months in Japan as a research scholar at the world renowned Tohoku University designing the “Gripper”, the next generation of climbing robots to explore the surfaces of Moon, Mars and near-by Asteroids. Not to mention, having held multiple talks and seminars at universities locally within the country and internationally. Hatem was invited to be a jury member at Google, for the Lunar X-Prize Moon Bots challenge. In 2015, Hatem came onboard to Killa Design where he has spent his time designing for 'the future'. Being involved with projects like the Museum of the Future and Office of the Future for the Dubai Future Foundation, it is clear that he no signs of slowing down! During a brief sabbatical in 2016, Hatem obtained masters degree in Space Studies at the international space university in France, where he focused his research on utilizing artificial intelligent on developing the next architectural construction methods on extra-terrestrial planets. Since then he has returned to Killa Design, where he currently practices. Early last year, Hatem went on to setup Space Roasters Inc, an aerospace startup with a twist, pushing the boundary of space and science!.. Oh wait, Did we mention he's given a TEDx Talk on Lunar Architecture in his spare time? Wrote the first book to conclude codes to guide future architects designing on the Moon? Have a space technology design patent registered in the US and UAE? And participated in many NASA competitions, where his work lately exhibited at the famous NASA JPL in Houston, the same center that launched Neil Armstrong to the Moon!?. We are truly honored to have our first space architect on the show! To stay updated with our weekly episodes, please follow us on your favorite streaming plattform Follow us on our socials The aForm Show - Instagram | LinkedIN Audio by Strum@ease - Instagram | Youtube . . Follow our awesome guests! Hatem Al Khafaji | Instagram Killa Design | Instagram Space Roasters Inc | Instagram . . Much love to our friends & supporters Inscape Education Management - Instagram | Facebook | LinkedIN Orange Design Group - Instagram | LinkedIN . . Want to get on the show or know someone who should be? Email us at hello@aform.studio --- Send in a voice message: https://podcasters.spotify.com/pod/show/theaformshow/message

This month on Episode 6 of the Discover CircRes podcast, host Cindy St. Hilaire highlights five featured articles from the October 25 and November 8, 2019 issues of Circulation Research and talks with Coleen McNamara and Aditi Upadhye about their article, Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis.   Article highlights:   Omura, et al. ADAMTS8 in Pulmonary Hypertension.   Rödel, et al. Blood Flow Suppresses CCM Phenotypes in Zebrafish   Cai, et al. Proteomics Assessment of hPSC-CM Maturation   Shin, et al. Leptin Causes Hypertension Via Carotid Body Trpm7   Lin , et al. Cellular Heterogeneity in Elastin Deposition   Transcript Dr Cindy St. Hilaire:          Hi. Welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire and I'm an assistant professor of medicine at the University of Pittsburgh. In this episode I'm going to share with you some highlights from recent articles that were published in the October 25th and our November 8th issues of Circulation Research. We're also going to have an in-depth conversation with doctors Coleen McNamara and Aditi Upadhye, who are the lead authors in one of the exciting discoveries from our October 25th issue. The first article I want to share with you is titled ADAMTS8 promotes the development of pulmonary arterial hypertension and right ventricular failure, a possible novel therapeutic target. The first author is Junichi Omura and the corresponding author is Hiroaki Shimokawa, and the work was conducted at Tohoku University, Sendai, Japan. Pulmonary hypertension is caused from the excessive proliferation of the vasculature in the lungs. It has contributions from smooth muscle cells, endothelial cells, inflammatory cells, and these cells proliferate and occlude the small vessels in the lungs. And this occlusion leads ultimately to failure of the right heart ventricle. Current therapies only treat the symptoms, not the underlying pathology. So there really is a big push right now to try to discover novel therapeutic targets. The authors of this study performed a gene expression screen, and in this screen, they compared pulmonary artery smooth muscle cells from pulmonary hypertension patients to those same cells from healthy controls. The research has found numerous differentially-expressed genes. However, they chose to focus on one called ADAMTS8. And they focused on this because the protein is expressed specifically in the lungs and heart tissues, and it was significantly upregulated in the patient's cells. So ADAMTS8 is a secreted zinc dependent protease, and this protease function makes it potentially a druggable target. So similar to human cells, ADAMTS8 was also found to be upregulated in the lungs of mice with pulmonary hypertension and a lack of vascular ADAMTS8 attenuated the disease symptoms. Conversely, overexpression of ADAMTS8 in pulmonary artery smooth muscle cells from both mice and humans prompted increased proliferation. They performed a high throughput screen to try and identify compounds that would suppress ADAMTS8 and pulmonary artery smooth muscle cell proliferation. And in this screen, they found mebendazole, which is a drug that is already in clinical use for parasitic worm infections. Thus, the study not only pins ADAMTS8 as a driver of pulmonary hypertension, but also suggests a potential existing drug might be useful for treating it. The next manuscript I want to share with you is titled Blood Flow Suppresses Vascular Anomalies In a Zebrafish Model of Cerebral Cavernous Malformations. The first author is Claudia Jasmin Rödel, and the corresponding author is Salim Abdelilah-Seyfried, and they are from the University of Potsdam in Potsdam, Germany. Vessel diameter and geometry as well as blood velocity and flow speed, all affect how the flow of blood impacts biomechanical forces that are received by the endothelial cells that line the lumen of vessels. Pathological changes in biomechanical signaling pathways or abnormal patterns of blood flow have been implicated in the etiology of various vascular diseases, and this manuscript is focusing on one: cerebral cavernous malformations, or CCMs. There are various genetic causes of CCMs, and this combined with several lines of evidence, point to a role for blood flow in CCM lesion development. Specifically, patients typically develop CCM lesions only in low perfused venous capillaries. Those are slow flow vessels. Rarely are high flow vessels affected. The authors want to answer the question, why do CCMs develop in low flow areas and more broadly, what is the role of hemodynamic forces in CCM pathology? To explore the role of blood flow and vascular remodeling, they use a zebrafish model. This is a great model to study this specific type of malformation, because the zebrafish itself is transparent and you can do an amazing way of imaging and I highly recommend that you go online and check out some of the videos that are supplemental figures for this paper. They're beautiful, they're neat, and you can really see the blood flow in these zebrafish models that they use. Okay, so which models did they use? They used ones that had normal levels of blood flow or normal speeds of blood flow, and then a zebrafish that is actually absent of any blood flow. Which is crazy that it can live for any amount of time. And so they use these zebrafish and looked at the lateral dorsal aorta, which is a high shear stress vascular bed. They found that blood flow induces a protective response in endothelial cells. This finding helps to explain why CCM patients never suffer from vascular anomalies within highly perfused blood vessels since these vessels are protected by the flow itself. The next paper I want to highlight is titled An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. The first author is Wenxuan Cai and the corresponding author is Ying Ge, and they are from the University of Wisconsin Madison in Madison, Wisconsin. Cardiomyocytes are the beating cells of the heart and they're very difficult to work with in culture as they don't proliferate very well. As such, scientists are moving to use human induced pluripotent STEM cells as means to create cardiomyocytes. So cardiomyocytes derived from human pluripotent stem cells are a valuable resource for drug discovery and screening and disease modeling. While useful, these pluripotent stem cell-derived cardiomyocytes remain immature compared to their natural adult counterparts, and this immaturity slightly reduces their utility. So there are now several methods that people use to promote maturation of cardiomyocytes, but currently there's no consensus on the best way to assess cardiomyocyte maturity, or rather, IPS cardiomyocyte maturity. In this manuscript, Cai and colleagues have established a straightforward yet comprehensive mass spectrometry approach to ensure cardiomyocyte maturity. This method combines analysis of a subset of intact proteins with an unbiased screen of digested peptide fragments. The team used the method to examine early and late stage maturation of cardiomyocytes derived from embryonic, as well as human induced pluripotent stem cell sources, validating their findings against cells from mouse hearts. For the intact protein analysis, sarcomeres were isolated from cell samples which enabled the identification of the major sarcomeric proteins, as well as any post-translational modifications on these proteins that can fine tune our assessment of maturity. The unbiased screen further identified both known and novel maturation markers. This study not only provides a handy tool for assessing IPS-derived cardiomyocyte maturity, but it also defines a set of maturity markers for cross reference in future studies. The next paper I want to discuss is titled Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7, Trpm7, Channel In the Carotid Body. The first author is Mi-Kyung Shin, and the corresponding author is Vsevolod Polotsky, and they are from the Johns Hopkins University in Baltimore, Maryland. Leptin is a hormone that is secreted from fatty tissue, and it's secreted in response to eating something fatty and delicious. Leptin signaling increases metabolism and blood pressure, and it also helps to reduce appetite. That is, if you don't eat the fatty food too fast. So, obese individuals can exhibit high levels of leptin, yet their metabolism and appetite may be unaltered, while hypertension may still develop. Leptin's effects on appetite metabolism are mediated via signaling in the brain, while its effects on blood pressure are thought to be mediated elsewhere. In this manuscript, the authors suspected that the carotid body has something to do with this. The carotid body is a cluster of cells in the neck that detect blood levels of oxygen and other substrates, and the carotid body cells can communicate the information to the brain via the carotid sinus nerve. The carotid body has abundant expression of leptin receptor, and moreover, leptin has been shown to increase carotid sinus nerve firing. So in this manuscript, the authors now show that infusions of leptin into mice increased hypertension in the animals only when the carotid sinus nerve was intact. They also showed that hypertension in these mice was dependent on the iron channel Trpm7, which is very abundant in the carotid body. Inhibition of Trpm7 prevented the leptin-induced hypertension. Together, these results begin to explain why obese individuals' leptin still induces hypertension when the hormone's other effects on appetite and metabolism are diminished. They suggest that inhibition of Trpm7 could perhaps be a way to treat the hypertension seen in obese individuals. The last paper I want to highlight before we move over to our interview is titled Heterogeneous Cellular Contributions to Elastic Laminae Formation and Arterial Wall Development. The first author is Chien-Jung Lin, and the corresponding author is Jessica Wagenseil from the Washington University in St. Louis. Elastin is the extracellular matrix protein that provides structure to both large and small arteries. Vascular smooth muscle cells are known to produce the layered elastic laminae found in elastic arteries. However, they synthesize very little elastin in more muscular arteries. Muscular arteries also have well-defined internal elastic laminae that separates the smooth muscle cells from the endothelial cells, but the source of the elastin in these muscular arteries is not well-defined. The goal of this study was to define the extent to which endothelial cells can contribute to elastin in the eternal elastic laminae of various arteries. To address this question, they created several new strains of mice in which elastin is deleted specifically in a smooth muscle or an endothelial cell. They found that smooth muscle cells and endothelial cells can both independently form an internal elastic lamina in elastic arteries. In muscular and resistance arteries, however, endothelial cells are the major source of elastin. Further, in the ascending aorta, it was noted that ill-formed internal elastic laminae was associated with neointimal formation, confirming that the internal elastic laminae is a critical physical barrier for smooth muscle cells and endothelial cells in large elastic arteries. This study provides new information about how smooth muscle cells and endothelial cells contribute to elastin production in the artery wall, and also how local elastic laminae defects may contribute to cardiovascular disease. I'm here with Dr Coleen McNamara and Aditi Upadhye, and we'll be discussing their paper titled Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. And this paper is was published in our October 25th edition of the journal. So thank you both so much for joining me today. Dr Coleen McNamara:    Thank you for having us. Dr Aditi Upadhye:            Thank you. Dr Cindy St. Hilaire:          I'm really looking forward to learning more about this paper. First, I'm wondering if you could just please introduce yourselves and give us a little bit about your background. Dr Coleen McNamara:    Well, I'm Coleen McNamara. I'm a physician scientist in the Cardiovascular Research Center at the University of Virginia in cardiovascular medicine. And my laboratory studies B cells and atherosclerosis predominantly. And that's the topic of Aditi's paper. Dr Aditi Upadhye:            And I'm Aditi Upadhye. I'm a PhD student in Coleen's lab and my project in Coleen's lab has focused on the role of CXCR4 in B-1 cell IgM production in atherosclerosis. Dr Cindy St. Hilaire:          If this is your project, you must be nearing the end of graduate school then. Dr Aditi Upadhye:            Yes, very close. Dr Cindy St. Hilaire:          Excellent. And congratulations on a beautiful paper. Dr Aditi Upadhye:            Thank you so much. Dr Cindy St. Hilaire:          So I was just reading the paper and I did see that you stated the objective of the paper, was that you wanted to characterize bone marrow IgM repertoire and determine whether CXCR4 regulated the B-1 cell production of this atheroprotective IgM. Could you maybe just give us a quick primer on what all those words mean? What is a B-1 cell, what is IgM, and what is this atheroprotectiveness, and why is this important to research? Dr Aditi Upadhye:            Sure. So research over the past few decades has shown that the role of B cells in atherosclerosis is subset specific. So in mice there are two broad categories of B cells. B-1 and B-2. And B-2 cells are the ones you typically learn about in immunology classes. They're the ones that produce really high affinity class-switched antibodies in a T-cell dependent manner. And there is evidence that B-2 cells are atherogenic. So either through their ability to modulate T-cells through cytokine production, or through their production of IgG and IgE antibodies, they may have atherogenic capability. B-1 cells are very, very different. They produce what are called these natural IgM antibodies. So they're present even in germ-free mice that don't have any prior antigen exposure, exogenous antigen exposure. And the kind of paradigm in the field thus far had been that B-1 cells produce germline-encoded antibodies. So they don't acquire quite as much diversity as their B-2 cell counterparts do. And really importantly, it has been shown that B-1 cells are an atheroprotective cell subset, primarily through their ability to produce IgM. So our coauthor, Dr Joseph Witztum, previously demonstrated that B-1 cells produced IgM antibodies against oxidation specific epitopes that arise on oxidized LDL in atherosclerosis. But really the mechanisms that regulate IgM production and what these IgMs are targeted against is less known. And that's something that we were trying to get at with this paper. Dr Cindy St. Hilaire:          One of the things you talked about in one of the earlier figures in your paper was that there's differences in the chemokine expression between these B cells that are in the spleen versus when they're in the bone marrow. And these differences are apparent at baseline, but also under hyperlipidemic conditions. Is there a cause or a consequence angle to asking this question about B-1 cells and atheroprotectiveness? Dr Aditi Upadhye:            Yeah, I think so. One of the points of this paper is that B-1 cells are very heterogeneous and so they may be going to multiple locations, not just the bone marrow, which we focus on in our paper, but also the spleen, also the perivascular adipose tissue, are sites that we're also interested in looking at. So the fact that there is different chemokine ligand expression level on these different sites might guide them to these different places and might help with their function. Dr Cindy St. Hilaire:          Yeah, and I guess that's a perfect segue for my next question. And it seems that the CXCR4 expression on the cells is really key to their proper migration and then the subsequent secretion of the IgM. Do we know what's happening to CXCR4 expression either as we age or as atherosclerosis progresses? Is there any evidence of environmental or behavioral or genetic angles that might predispose an individual to having more or less CXCR4 on their B cells? Dr Aditi Upadhye:            That's a great question. So there are a lot of things that regulate chemokine receptor expression, including expression of the ligands too. I don't know that much about how CXCR4 expression changes with age or with atherosclerosis. At least in mice, it seems that CXCR4 doesn't change during hyperlipidemia. So for example, in C57 black 6 mice versus a ApoE knockout mice, either child fed or Western diet fed, CXCR4 doesn't seem to change on the one cell subsets. Dr Cindy St. Hilaire:          Interesting. Maybe a future project then. Dr Aditi Upadhye:            Yeah. Yeah. Dr Cindy St. Hilaire:          So I found it really interesting, I think it was in figure five, I always like to try to pick out my favorite figures. My favorite figures of this paper are three, five, and seven. And so... Are those your favorite? But so I guess one of the things that I thought was interesting is that you made a mouse, a multiple knockout mouse that had ApoE knockout and it also was not able to make IgM antibodies. Is that correct? So when you took that mouse and then you looked at it, I think at 80 weeks of age, you could see differences in the atherosclerosis on these mice, but then you couldn't see it on kind of the standard model of what probably most atherosclerosis labs use. And that is a younger mouse that's put on a high fat diet for a shorter window of time. And so could you maybe talk about what that difference means, what your study shows, and then how do we move forward with studying the role of inflammation and atherosclerosis in younger versus older mice? Dr Aditi Upadhye:            Yeah, that's a great question. And I think that every model has its caveats that, and that's something that we ran into when we were trying to show whether B-1 cell CXCR4 is important in atheroprotection. But I think what our findings suggest is that there is a very delicate balance between the amount of IgM that you have and the lipid burden that you have. And in any given model, these might be factors to consider when it comes to studying atherosclerosis. Just taking those factors into consideration when you're analyzing your atherosclerosis results. Dr Cindy St. Hilaire:          Absolutely. Dr Coleen McNamara:    One of the reasons we liked this 100-week-old, or the 80-week-old mouse is the one where if it doesn't have IgM, there's significantly more atherosclerosis even on a chow diet. And so that's a cholesterol of about 300 or 400, and then an 80 to a 100-week old mouse is about the equivalent of a 70-year-old person, which is sort of more akin to the human situation. And so in that setting, the IgMs matter, whereas it didn't look like the IgMs as Aditi said were really capable of blocking the oxidized lipids that were generated in younger mice that had cholesterols well over a thousand. So we felt like that that was really relevant, which is why we use that same model for when we did the single cell sorting and sequenced the antibody repertoire. Thinking that that would give us more insight into the role of age and modest hyperlipidemia, which is more the clinical scenario. Dr Cindy St. Hilaire:          Do you think that has implications for how humans with familial hypercholesterolemia are treated versus someone with just a lower level but still elevated lipid profile? Dr Coleen McNamara:    Yeah, I do, and I think that's really an important point, Cindy, because the vast majority of people that suffer from cardiovascular disease, have heart attacks, die of cardiovascular disease, are typically older people with modest cholesterol levels. Familial hypercholesterolemia, obviously in those patients, they get significant cardiovascular disease at young ages. But that's certainly in a relative sense, a much less common occurrence. So I think that the model and the mechanisms that we were looking at are more applicable than garden variety atherosclerosis. Dr Cindy St. Hilaire:          Interesting. That's something I haven't really thought about. We always just kind of use these mice to model athero and try to do it in the quickest way possible to get the papers out. But it's really interesting. Dr Coleen McNamara:    We use a lot of mouse models and we use young models with hypercholesterolemia in our laboratory as well. So I think that there's a real role for doing that. And a lot of people have really advanced the field with those types of models as well because they allow you to ask mechanistic questions. Dr Cindy St. Hilaire:          One of the things you mentioned in the paper was the variability of the IgMs produced, that there's not just one IgM, there's different flavors, I guess is a way to put it. Can you maybe just talk about that a little bit, what that might mean? And then I have another follow-up question after that. Dr Aditi Upadhye:            Sure. So B-1 cells, the B cell receptor, it's different on different B cells. And so that is made through a process called VDJ recombination. And the B cell receptor determines what your antibody is going to be specific for. There's a lot of different IgMs present within a given B cell repertoire because the differential combination of all these genes makes up the repertoire. Dr Cindy St. Hilaire:          What is it about the IgM that makes it atheroprotective, what's it actually targeting? Dr Aditi Upadhye:            That's a great question. So Dr Witztum and colleagues and others have shown that these IgMs target oxidation specific epitopes. And for example, one of them that we focus on in this paper is malondialdehyde-modified LDL. And so these IgMs can recognize MDA and either facilitate its clearance or prevent it from being bound to macrophages and prevent inflammatory processes within those macrophages downstream. Dr Cindy St. Hilaire:          So essentially this IgM is kind of working to prevent foam cell formation? Dr Aditi Upadhye:            Yes. Dr Cindy St. Hilaire:          Excellent. Dr Coleen McNamara:    So these are, these modified lipids are danger associated molecular patterns, as you've heard about before. So not only are these modified lipids taken up into the macrophage by scavenger receptors, which we know is an atherogenic, a process that leads to atherosclerosis, but they can also activate inflammatory pathways through toll-like receptors. Dr Cindy St. Hilaire:          So in light of the variability, I guess what I'm wondering is, is there more variability in these IgMs based on atherosclerotic state or in humans, healthy or control, and then also how are these heterogeneous populations of cells, how does your finding coincide with the recent studies on clonal hematopoiesis? And I was wondering if you could talk a little bit about that. Actually, for people who don't know, the idea... I guess I should explain the idea of clonal hematopoiesis. So essentially there was a recent paper in Science by Ken Walsh, who's actually at UVA now, where they found that there's acquired mutations in hematopoietic stem cells, and as we age, those mutations can become enriched and therefore somewhat clonal, hence the term clonal hematopoiesis. So how does the variability of the B cell population kind of work with this clonal hematopoiesis theory? Dr Coleen McNamara:    Well, it's interesting that you ask that because that's actually another direction within the lab. So we're collaborating with Dr Walsh and Jose Fuster, who was the first author on that Science paper. And we think, and in particular related to Aditi's work, that this particular subset of B cells has quite a propensity for clonality. And what she was actually able to show is, in terms of the B-1a cells within the peritoneal cavity, when their complementarity determining region three was sequenced, which is the main region responsible for recognizing the antigen-in 70% of the single cells that were sequenced, it was identical. So that actually is quite clonal. Dr Cindy St. Hilaire:          Yeah. So essentially if it was random, you would expect those numbers to be much lower. Much more variable. Dr Coleen McNamara:    Absolutely. But yet in the bone marrow, we saw much less of any given sequence being overrepresented. And in addition, there was evidence that there was modification in the antibody repertoire in adult life. Sort of suggesting and getting back to your earlier questions, that it actually may be atherogenic stimuli or hyperlipidemia that could be stimulating selection of other B cell clones. Dr Cindy St. Hilaire:          Interesting. So we have a lot of chicken and egg questions to ask for the future. Dr Coleen McNamara:    Yeah, exactly. And we're really getting into that space because we do think that the subtype of immune cell lends itself to clonal expansion. Dr Cindy St. Hilaire:          I guess I want to end with one question about the translatability of some of your findings. So the last figure, figure seven, you show an inverse relationship between the level of CXCR4 on these B-1 cells with increasing plaque burden. And essentially I think the analysis you did suggests that it was actually very predictive, even more so than lipid levels. So is there base for this as a biomarker of sorts do you think moving forward? Dr Aditi Upadhye:            Yeah, I think that's how we'd like to move forward in the lab is to look at how CXCR4 might be atheroprotective on these B-1 cells. And if we can find a good preclinical model to test that and see how it's atheroprotective in a more mechanistic way, that would be great. I think also that our ability to show that increasing CXCR4 on mouse B-1 cells and getting them to increase their localization to the bone marrow and increase IgM production, that also indicates that this could be feasible. But whether or not that can be atheroprotective is a question for the future. Dr Cindy St. Hilaire:          That's great. Well thank you so much for taking the time speaking with me today. This was an amazing story with very cool implications for the future, and Aditi, I look forward to following your bright career in the future. Dr Aditi Upadhye:            Thank you so much for the opportunity. Dr Coleen McNamara:    Thank you. Dr Cindy St. Hilaire:          Thank you. Well, that's it for our highlights from the October 25th and November 8th issues of Circulation Research. Thank you so much for listening. This podcast is produced by Rebecca McTavish, edited by Melissa Stoner, and supported by the Editorial team of Circulation Research. Some of the copy texts for the highlighted articles was provided by Ruth Williams, and I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your source for the most up to date and exciting discoveries in basic cardiovascular research.  

Alzheimer's Speaks - Shifting Dementia Care from Crisis around the world one episode at a time by raising all voices and delivering sounds news, not just sound bites. Alzheimer's Speaks Radio Host, Lori La Bey talks with Jill Ricker, the Director of Operations for SAIDO Learning. SAIDO Learning was developed by the Kumon Institute of Education (Kumon) of Osaka, Japan, in conjunction with Professor Ryuta Kawashima of the Smart Aging International Research Center (SAIRC) at Tohoku University in Sendai. It has been practiced for more than 18 years in more than 1,600 nursing facilities across Japan, showing increased engagement in over 18,000 older adults. The goal of SAIDO Learning is to not only provide care for individuals with dementia, but to improve their quality of life through intentional engagement opportunities. Contact Jill Ricker via:   Website          Email            Phone  216.905.0296 Additional Resources at Alzheimer's Speaks          Dementia Chats          Speaking/Training/Consulting          Memory Cafes       Become Dementia Friendly

Yuki Hanyu got his Ph.D in chemistry from Oxford University in 2010. After working as a research scientist in Tohoku University and Toshiba Research and Development Center, he founded the "Shojinmeat Project", the world’s first citizen science community for DIY open-source cell-based meat. Based on the low-cost cell culture technology developed in Shojinmeat Project, he founded IntegriCulture Inc. in 2015 to commercialize cell-based meat. The company develops the general-purpose large-scale cell culture system (CulNet System) to scale and commercialize cell-based products such as cosmetics, foie gras and meat, while Shojinmeat Project develops DIY cell-based meat and engage in public communications through art and doujin projects. He aims to build a Lunar and Martian cell-cultured food production facility to support thousands of colonists there in the future, and develop technologies so that anyone can design and make cell-based meat for fun. --- Support this podcast: https://anchor.fm/futurefoodshow/support

On March 11, 2011, Kazuya Yoshida's lab at Tohoku University in Japan started shaking. Things fell from the ceiling. The bookshelves collapsed. Off the coast of the city of Sendai, the ocean floor had ruptured, triggering a magnitude 9 earthquake and tsunami waves that inundated inland regions. Although it only lasted minutes, time seemed to dilate. When it was finally over, nearly 16,000 people were dead. For many of those left, there was no water, no power, no phone connection.

Today’s show was recorded at the Canadian Space Society’s annual Space Summit in Ottawa on November 21st. Among the keynote speakers invited by the Canadian Space Society are usually two from outside Canada. I spoke with Dr. Kazuya Yoshida of Tohoku University in Japan. Dr. Yoshida is also a Director and Chief Technology Officer of iSpace, a Japanese New Space startup with ambitions to use the moons resources, water to start, to develop a lunar economic base. iSpace also manages the Japanese Google Lunar X Prize entry, Hakuto. Dr. Yoshida is a robotics expert and has served as the Director of the Centre of Robotics for Extreme and Uncertain Environments at Tohoku University. He has worked for many years on Japanese robotic missions including the asteroid sample return mission Hayabusa. The technology and rovers developed at his lab at Tohoku University have also been used in disaster response. Dr. Yoshida and his colleagues at Tohoku University are also developing what he calls “Cliff Hanger” and “Rock Climber” robotic machines designed for future asteroid exploration and which could also be used on the moon. Dr. Yoshida and his colleagues have developed a rich knowledge base in microsatellite and rover technology development. As you’ll hear, iSpace is looking beyond the Google Lunar X Prize and will announce its first round of equity venture funding in the near future.

Proof Positive - Motorcycle Riding Good for the Soul Anyone who rides a motorcycle can probably tell you that riding a motorcycle isn’t just a form of transportation, it’s an experience. When you return from a motorcycle ride, you are energized and happy. Many motorcyclists refer to riding as their therapy. Feel bad? Need to sort out a problem? Ride. It works. Motorcycle riding releases endorphins which improve moods. Simple as that.    Studies show that riding motorcycles, both on and off-road, have both physical and mental health benefits.    In 2010, Tohoku University in Japan jointly with Yamaha conducted research in to the relationship between brain stimulation and riding motorcycles. Researchers measured brain activity to confirm whether riding a motorcycle activates the PFC, the prefrontal cortex. The PFC has been  linked to a persons planning behaviours, personality development, decision making and social behaviour. Then they examined the effect of using a motorcycle daily. They found that the bilateral PFC was activated when riding a motorcycle and that daily riding is beneficial for improving various cognitive functions and for reducing mental stress.    A study on the “Quality of Life of Recreational Off-Road Riders” in 2010 as published in the Health & Fitness Journal of Canada, concluded that “habitual off-road riders appear to have relatively high physical and mental functioning, possibly as a result of their participation in recreational off-road riding. Both ATV (All Terrain Vehicles) and ORM (Off Road Motorcycle) riders revealed high QOL (Quality of Life) based on their MSC (Mental Component Scale) scores.” and “Overall, off-road riders had higher levels of physical functioning than Canadian population norms”.    Changing & Saving Lives With Motorcycle Therapy - Dave Frey from Veteran’s Charity Ride   In this episode Jim talks with Dave Frey, the founder of Veteran’s Charity Ride to Sturgis. VCR takes wounded and amputee veterans on motorcycles, trikes and sidecars from Los Angeles to the Sturgis Bike Rally in South Dakota. They’ve had great success with their program helping vets deal with and work toward overcoming their post-war challenges.    Website: http://veteranscharityride.org   Graham Field - Living the Good Life on a Motorbike   Graham Field, motorcycle adventure author, tells us how motorcycling has changed his life.   Website: http://grahamfield.co.uk   Sources:  Tohoku University/Yamaha Research http://www2.idac.tohoku.ac.jp/dep/sairc/research.html Health & Fitness Journal of Canada:  http://atfiles.org/files/pdf/OHV-Rider-Health-Fitness-Journal-Canada.pdf   Rider Skills - Rider Wear - Bret Tkacs Improve and master your riding techniques with some great tips from Bret Tkacs from Puget Sound Safety Off Road. Bret is a skilled expert and this episode’s instructor. Website: www.pssor.com   Brought to You By:   Max BMW Motorcycles Shop our Online Store featuring parts diagrams for every BMW model. Ordering parts and accessories has never been easier. Choose your bike, look at the diagrams and place your order. We have over 45,000 parts in-stock and our Parts Express team processes and ships orders six days a week via UPS, FedEx and USPS. www.maxbmw.com   BestRest Products Home of the CyclePump Tire Inflator, TireIron BeadBrakR, EZAir Tire Gauge, and other adventure motorcycle gear.  When you’re on the road you’ll want a compact and reliable method of tire inflation.  The CyclePump runs off your bike’s electrical system and it’ll fill a flat tire in less than 3 minutes.   It’s made in the USA and it comes with a 5-year warranty.  BestRest also makes tire changing and tire repair kits that are small enough to fit in your saddlebag.  The crew at BestRest are adventure riders themselves, so they know what you’ll need when you’re exploring the world. www.CyclePump.com   Aerostich The best way to ride more is to make riding your easiest, fastest way to get from A to B…simple everyday commuting and errands, long-distance adventure riding, or whatever. For 33 years Aerostich has been designing, making and selling equipment that makes riding anywhere, in all-weather – easier, safer, more comfortable and more fun. No other riders’ gear offers the proven protection, precise fit or lifelong value of an Aerostich. Prove it to yourself with the Ride-More Guarantee. If you try any Aerostich one piece R-3 or Roadcrafter Classic suit for one month, and are not riding more than you did before receiving it, send it back and you will receive a full refund, no questions asked. For complete details and to view all of the available equipment for riders, and for a 10% discount on your first Aerostich purchase, or free shipping on the next order for existing customers, visit www.aerostich.com/arr.   Giant Loop A rider owned company born from a desire to carry camping gear on enduro bikes into the demanding, rugged high desert country of eastern Oregon.  Giant Loop is the exclusive North American importer for Rally Raid Products Honda CB500 kits, parts and accessories.  Giant Loop offers adventure proof packing systems, modular customizable bags and gear for small enduro bikes to adventure touring machines. Choose the individual components to carry the gear you need on the bike you ride. “The best hard-core saddlebag and tank-bag solution we’ve found…” - Cycle World Magazine, Nov 2015. Proven by adventure riders on every continent but Antarctica.  Get free shipping in the USA with promo code: ARR.  www.giantloopmoto.com   In Association With:   The Good Adventure Company The Good Adventure Company was founded by J.J. Lewis in 2015 and is a major supporter for Lost for a Reason, who’s projects benefit children and families on the Navajo Nation, as well as other life-changing projects throughout the US and the world. All products sold have been tested and used by The Good Adventure Company and when you make a purchase with them the funds go directly to support the projects and help to make the world a better place.Offering a no-nonsense satisfaction guarantee, a 10% yearly dividend and free shipping in the USA on most products. www.good-adv.com   See more motorcycle podcasts at www.adventureriderradio.com

Running Time : 5minutes Overview: Not so long ago scientists thought there were only two types of solids: crystals, composed of order arrangements of atoms, and amorphous materials, in which the atoms are connected in a disorder fashion. But then a third type of solid was discovered, overturning the conventional wisdom. These new materials, called quasicrystals, have fascinated scientists with their beauty and strangeness. We will explore the mysterious world of quasicrystals. (Japanese edition has been published in Oct 7, 2014) Cast: An-Pang Tsai(Professor, Tohoku University), Tomonari Dotera(Professor, Department of Science, Faculty of Science and Engineering, Kinki University) JST Science News 2014(EnglishVer.) http://sciencechannel.jst.go.jp/Q140001/ JST Science News 2014(JapaneseVer.) http://sciencechannel.jst.go.jp/M140001/ JST Science Channel(Non-Japanese Programs) http://sciencechannel.jst.go.jp/non_japanese.html (c)Japan Science and Technology Agency

Running Time : 5minutes Overview: Not so long ago scientists thought there were only two types of solids: crystals, composed of order arrangements of atoms, and amorphous materials, in which the atoms are connected in a disorder fashion. But then a third type of solid was discovered, overturning the conventional wisdom. These new materials, called quasicrystals, have fascinated scientists with their beauty and strangeness. We will explore the mysterious world of quasicrystals. (Japanese edition has been published in Oct 7, 2014) Cast: An-Pang Tsai(Professor, Tohoku University), Tomonari Dotera(Professor, Department of Science, Faculty of Science and Engineering, Kinki University) JST Science News 2014(EnglishVer.) http://sciencechannel.jst.go.jp/Q140001/ JST Science News 2014(JapaneseVer.) http://sciencechannel.jst.go.jp/M140001/ JST Science Channel(Non-Japanese Programs) http://sciencechannel.jst.go.jp/non_japanese.html (c)Japan Science and Technology Agency

For 50 years, scientists have been trying to make an artificial placenta. Such a device could revolutionise the treatment of extremely premature babies. On this podcast, Yuichiro Miura from Tohoku University in Japan talks about his new, compact design. See acast.com/privacy for privacy and opt-out information.

The research focuses on providing reliable spatial information in support of tsunami risk and vulnerability assessment within the framework of the German-Indonesian Tsunami Early Warning System (GITEWS) project. It contributes to three major components of the project: (1) the provision of spatial information on surface roughness as an important parameter for tsunami inundation modeling and hazard assessment; (2) the modeling of population distribution, which is an essential factor in tsunami vulnerability assessment and local disaster management activities; and (3) the settlement detection and classification from remote sensing radar imagery to support the population distribution research. Regarding the surface roughness determination, research analyses on surface roughness classes and their coefficients have been conducted. This included the development of remote sensing classification techniques to derive surface roughness classes, and integration of the thus derived spatial information on surface roughness conditions to tsunami inundation modeling. This research determined 12 classes of surface roughness and their respective coefficients based on analyses of published values. The developed method for surface roughness classification of remote sensing data considered density and neighborhood conditions, and resulted in more than 90% accuracy. The classification method consists of two steps: main land use classification and density and neighborhood analysis. First, the main land uses were defined and a classification was performed applying decision tree modeling. Texture parameters played an important role in increasing the classification accuracy. The density and neighborhood analysis further substantiated the classification result towards identifying surface roughness classes. Different classes such as residential areas and trees were combined to new surface roughness classes, as “residential areas with trees”. The density and neighborhood analysis led to an appropriate representation of real surface roughness conditions. This was used as an important input for tsunami inundation modeling. By using Tohoku University’s Analysis Model for Investigation Near-field Tsunami Number 3 (TUNAMI N3), the spatially distributed surface roughness information was integrated in tsunami inundation modeling and compared to the modeling results applying a uniform surface roughness condition. An uncertainty analysis of tsunami inundation modeling based on the variation of surface roughness coefficients in the Cilacap study area was also undertaken. It was demonstrated that the inundation modeling results applying uniform and spatially distributed surface roughness resulted in high differences of inundation lengths, especially in areas far from the coastline. This result showed the important role of surface roughness conditions in resisting tsunami flow, which must be considered in tsunami inundation modeling. With respect to the second research focus, the population distribution, a concept of population distribution modeling was developed. Within the modeling process, weighting factor determination, multi-scale disaggregation and a comparative study to other methods were conducted. The basis of the developed method was a combination of census and land use data, which led to an improved spatial resolution and accuracy of the population distribution. Socio-economic data were used to derive weighting factors to distributing people to land use classes. Moreover, in case of missing input data, an approach was developed that allows for the determination of generalized weighting factors. The approach to use specific weightings, where possible and generalized ones, where necessary, led to a flexible methodology with respect to the achievable accuracy and availability of data. A comparative study was performed by comparing this new model with previously developed population distribution models. The newly developed model showed a higher accuracy. The detailed population distribution information was a valuable input for the vulnerability assessment being the main data source for human exposure assessment and an important contribution to evacuation time modeling. In support of the population distribution research, settlement classification using TerraSAR-X imagery was conducted. A current classification method of speckle divergence analysis on SAR imagery was further developed and improved by including the neighborhood concept. The settlement classification provided highly accurate results in dense urban areas, whereas the method needs to be further developed and improved for rural settlement areas. Finally, it has been shown how the results of this research can be applied. These applications cover the integration of surface roughness conditions into the tsunami inundation modeling and hazard mapping. The contributions to tsunami vulnerability assessment and evacuation planning were shown. Additionally, the results were integrated into the decision support system of the Tsunami Early Warning Center in Jakarta.

This presentation shows how two seemingly contradictory concepts about social stratification in contemporary Japan - "fluidization" and "stabilization" - can be understood and explained in a coherent way. A classic example of "fluidization" is an increase in non-regular workers, while that of "stabilization" is an increase in the rigidity of intergenerational social mobility of a particular stratum. We hypothesize that the fluidization has not necessarily occurred at all strata; some strata have still been under the umbrella of protective institutions, while other strata have been being involved in the rapidly increasing fluidity.We argue that this hypothesis is generally supported by examining empirical findings made in the 2005 Social Stratification and Social Mobility Project. In conclusion we consider implications of the co-existence of "stability" of particular parts in social stratification and "fluidization" in the study of social stratification.Yoshimichi Sato is professor of sociology at Tohoku University and director of the Center for the Study of Social Stratification and Inequality. His recent publications include Deciphering Stratification and Inequality: Japan and Beyond (Trans Pacific Press) and Game Theory (Shinyo-sha, in Japanese).