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Arrancamos repasando todo lo ocurrido en el mundo NASCAR tras la semana de descanso: Austin Cindric se llevó la victoria en Talladega, la tercera de su carrera y la primera de 2025, en una carrera marcada por el accidente de Bell y las tensiones entre Logano y su compañero de equipo. También analizamos el polémico final de la Xfinity Series. En la Guía del Pueblo, ponemos el foco en el arranque del DTM en Oschersleben con victorias de Auer y Güven, y liderato para Jordan Pepper. Además, repasamos el GP de España de MotoGP con el triunfo de Álex Márquez, el dominio de Freddie Slater en GB3, el estreno de la EuroFormula Open con Yevan David en lo más alto, y el inicio de la F4 Británica con un sorprendente líder sin victorias: Tommy Harfield. ️ Estrenamos sección: Momento Motor-Deportivo, donde damos pinceladas de todo lo que dejó el fin de semana en categorías como el GT Open, BTCC, British GT y GB4. Y para cerrar, Jose Manuel González nos pone al día con todo lo sucedido en el Rally de las Islas Canarias del WRC. En directo todos los miércoles a las 22:00 en nuestro canal de Twitch y YouTube. Síguenos en redes: Twitch: https://www.twitch.tv/bumpandfun YouTube: https://www.youtube.com/@BumpAndFun Todos los podcast: https://www.podcastmotor.es Twitter: @AutoFmRadio Instagram: https://www.instagram.com/autofmradio/ YouTube: https://www.youtube.com/@AutoFM Contacto: info@autofm.es
We're firing on all cylinders and stirring the pot like it's Sunday arvo at the pub!
#TRDCSHOW S9 E3Join me at Silverstone during a GB3 test today.3 tips that will help you perform better as a race driver.I hope these helpEnzo❤ THANK YOU SUBSCRIBERS ❤The TRDC community is tight. Your comments, likes, shares, questions and subscriptions keep this channel alive and I just want to thank you for being a part of this. -------------------------------------------------------♛ ENZO'S BOOKS ♛If you want to read my books or listen to the Audiobooks then you can click below:The Warrior's Mind (Mental Training) https://amzn.to/3tKt0yfGet The Drive (Motorsport Sponsorship) https://amzn.to/3lrtmGU------------------------------------------------------More Links:The Race Driver Coach Website - http://www.theracedrivercoach.com/Spotify - https://spoti.fi/2WRyHth Instagram - https://www.instagram.com/enzomucci_ Facebook page - https://www.facebook.com/theracedrivercoach/ TikTok - https://vm.tiktok.com/ZSH6MgF4/ Soundcloud - https://soundcloud.com/enzomucci iTunes - https://apple.co/2KqCR9v --------------------------------------------------------Copyright Info: Music used in intro/outro was composed by Hustle Standard. Permission granted directly from Hustle Standard. View Hustle Standard and Never Gonna Stop song here - https://www.youtube.com/watch?v=oJH5AsNr_nMWe ensure that all images and video used are all for educational purposes so fall within the Fair Use policy. Thank you to all contributors.#TRDCSHOW #racedriver #motorsport #enzomucci #drivercoach #motivation #racing #driver #mentalcoach #mindset #f1
#TRDCSHOW S9 E2Join me at Silverstone during a GB3 test today.3 tips that will help you perform better as a race driver.I hope these helpEnzo❤ THANK YOU SUBSCRIBERS ❤The TRDC community is tight. Your comments, likes, shares, questions and subscriptions keep this channel alive and I just want to thank you for being a part of this. -------------------------------------------------------♛ ENZO'S BOOKS ♛If you want to read my books or listen to the Audiobooks then you can click below:The Warrior's Mind (Mental Training) https://amzn.to/3tKt0yfGet The Drive (Motorsport Sponsorship) https://amzn.to/3lrtmGU------------------------------------------------------More Links:The Race Driver Coach Website - http://www.theracedrivercoach.com/Spotify - https://spoti.fi/2WRyHth Instagram - https://www.instagram.com/enzomucci_ Facebook page - https://www.facebook.com/theracedrivercoach/ TikTok - https://vm.tiktok.com/ZSH6MgF4/ Soundcloud - https://soundcloud.com/enzomucci iTunes - https://apple.co/2KqCR9v --------------------------------------------------------Copyright Info: Music used in intro/outro was composed by Hustle Standard. Permission granted directly from Hustle Standard. View Hustle Standard and Never Gonna Stop song here - https://www.youtube.com/watch?v=oJH5AsNr_nMWe ensure that all images and video used are all for educational purposes so fall within the Fair Use policy. Thank you to all contributors.#TRDCSHOW #racedriver #motorsport #enzomucci #drivercoach #motivation #racing #driver #mentalcoach #mindset #f1
Kevin Turner sits down with Stephen Lickorish and special guest and Autosport National contributor Marcus Pye to chat about the racing series they're most looking forward to amongst the domestic scene in 2025. There's chat about British GT with Rob Collard going for a third series title with new teammate Hugo Cook at Barwell Motorsport. The strength in depth of GB3's 2025 roster is also spoken warmly about, including reigning Autosport Young Driver of the Year Deagen Fairclough and F1 Academy 2024 Champion, Abbi Pulling. Also included is the Walter Hayes Trophy and the 25th Anniversary year of the Formula Ford 1600 celebration, Super Touring Power 3 at Brands Hatch and more! If you would like to keep up with UK motorsport every week, take a look at our new National newsletter and sign up: https://manage.kmail-lists.com/subscriptions/subscribe?a=Vbb5eh&g=RL2Lcd Learn more about your ad choices. Visit podcastchoices.com/adchoices
Legenda mikrofonu - Andrzej Borowczyk podsumowuje sezon WEC z udziałem Roberta Kubicy. Daniel Biały dzieli się spostrzeżeniami dotyczącymi pełnego dramaturgii Grand Prix Sao Paulo Formuły 1.Tymek Kucharczyk mówi o swojej sytuacji budżetowej w sprawie walki o starty w FIA Formule 3. Co zmieniło się od czasu wypowiedzi kierowcy sprzed miesiąca (ta dostępna tutaj), która zapoczątkowała ogólnopolską akcję wsparcia dla Tymka. Goście programu:Andrzej Borowczyk - komentator Długodystansowych Mistrzostw Świata na kanałach PolsatuDaniel Biały - prowadzący kanału YouTube ,,Echa Padoku"Tymek Kucharczyk - zdobywca 3. miejsca w brytyjskiej GB3 w zespole Hitech Pulse Eight w sezonie 2024Prowadzą Kamil Kowalik i Piotr Nałęcz. Z wszystkimi wydaniami audycji „Czas na Motorsport” można się zapoznać tutaj.Audycja „Czas na Motorsport” w każdy wtorek o godzinie 20.00na antenie Radia Wnet. Zapraszamy!
The four finalists who will contest the 2024 Silverstone Autosport BRDC Young Driver of the Year Award have been selected. Formula 3 race winner Arvid Lindblad, recently crowned British F4 champion Deagen Fairclough, GB3 Champion Louis Sharp and Italian F4 Champion Freddie Slater will battle it out for prizes that include a test in Aston Martin F1 machinery and £200,000. Of the four finalists, only Lindblad has been a finalist before, in 2023. The drivers will be put through their paces in a thorough test of their fitness, as well as two days of testing at Silverstone in F2, GT3 and LMP3 machinery. Dre Harrison and Autosport Chief Editor (and Judge!) Kevin Turner is on the latest edition of the Autosport Podcast to talk about all four finalists' seasons, such as Fairclough's dominance in British F4, Lindblad's four wins as a rookie in F3, Freddie Slater taking the Italian F4 Crown, and Louis Sharp's recent GB3 title win, as well as a behind the scenes look at the judging process. Be sure to tune in on January 29th, 2025 to see who wins! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Tymek Kucharczyk z mieszanymi uczuciami podsumowuje sezon w brytyjskiej GB3, który zakończył na wysokim trzecim miejscu. Kierowca mówi o perspektywach na przyszłość.W programie również podsumowanie Rajdu Chile i rozważania na temat ostatniej części sezonu WRC. Także o 4-godzinnym wyścigu ELMS na Mugello i weekendzie MotoGP w Indonezji.Goście programu:Gabriel Borowy - dyrektor zarządzający ,,Motowizji",Tymek Kucharczyk - zdobywca 3. miejsca GB3 Championship, kierowca zespołu Hitech Pulse-Eight.Prowadzą Kamil Kowalik i Piotr Nałęcz.Z wszystkimi wydaniami audycji „Czas na Motorsport” można się zapoznać tutaj.Audycja „Czas na Motorsport” w każdy wtorek o godzinie 20.00 na antenie Radia Wnet. Zapraszamy!
Get Surfshark VPN at https://surfshark.deals/tracklimits - Enter promo code Tracklimits for 84% off and 4 EXTRA months for FREE! In this episode of the Track Limits podcast, we are joined by one of the successful technical directors, Christophe Perrin. In this episode, we have the privilege of speaking with Christophe Perrin, the Technical Director at Hitech GP, a team renowned for nurturing some of the finest talents in motorsport. With over 15 years of experience in various technical roles across Formula racing, including GB3, F3, F2, and DTM, Christophe has played a pivotal role in shaping the careers of drivers like Sebastian Vettel, Charles Leclerc, and Kamui Kobayashi. We dive into Christophe's current role at Hitech GP, exploring the state-of-the-art facilities that provide a cutting-edge environment for developing the next generation of racing stars. Christophe shares his approach to working with young drivers in lower categories, detailing how he manages expectations and helps them reach their full potential. Christophe offers unique insights into what he saw in drivers like Vettel and Leclerc that set them apart and how these qualities can be honed into championship-winning attributes. We also discuss the exciting prospect of Lewis Hamilton and Charles Leclerc being teammates next year and how Christophe believes this dynamic will shape Ferrari's championship ambitions. Finally, Christophe reflects on his leadership style, which has been instrumental in his success and provides his thoughts on the emerging duo of Oscar Piastri and Lando Norris, predicting when—not if—Piastri will outperform Norris. He also opens up about balancing his career with raising his children in the world of motorsport. This episode is a must-listen for anyone interested in the behind-the-scenes workings of motorsport and the making of champions. Tune in to hear from one of the industry's most experienced and insightful technical minds. Make sure to subscribe, review and follow us on our socials: https://www.instagram.com/tracklimits/ https://twitter.com/tracklimits_pod/ https://www.tiktok.com/@tracklimitspod Join our mailing list to learn more about Track Limits: https://www.tracklimitspod.com/ We have launched our MERCH STORE with some exclusive items. Unlock free shipping worldwide using the code FREESHIPPING at https://shop.tracklimitspod.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
FIA Formula 3 racer Kacper Sztuka and GB3 leader Tymek Kucharczyk join the Formula Scout Podcast to discuss growing up together in racing and their international exploits since leaving Poland.
John/Jogn Bennett/Bennet joins the podcast with George Brabner and Gavin Guthrie to talk about the start of the GB3, GB4, and British F4 seasons after a wet weekend in Britain. #gb3 #gb4 #formula4 #roadtof1 Don't forget to like this video and subscribe to the channel! Who says junior single-seater reporting has to be boring? The F1 Feeder Series crew is here to bring you the latest on the world of feeder series, from Formula 2 all the way down to Formula 4 and everything in between. Like what you hear? Follow everyone on this podcast! Jim Kimberley X: https://twitter.com/JimKimberleyJim Kimberley Instagram: https://www.instagram.com/jimakimberley/George Brabner X: https://twitter.com/GMB_31George Brabner Instagram: https://www.instagram.com/poost.31/Gavin Guthrie X: https://twitter.com/gsg_motorsportGavin Guthrie Instagram: https://www.instagram.com/g.s.g.motorsport/John Bennett X: https://twitter.com/john27bennettJohn Bennett Instagram: https://www.instagram.com/john27bennett/ Aside from Transfer Weekly, you can find us here! Website: https://feederseries.net Twitter: https://twitter.com/feeder_series Instagram: https://www.instagram.com/feederseriesnet
In this episode of the Track Limits podcast, we are joined by an up-and-coming British driver, William Macintyre. In this vibrant episode, we dive into the world of junior category motorsports with Will, currently competing in the GB3 championship with Hitech GP. Join us as Will shares his passions for sports, his aspirations in racing, his admiration for fellow drivers, his thoughts on F1, memorable experiences on and off the track, and much more. From the outset, Will's passion for sports shines through as he discusses his love for football and his journey into competitive racing. He reflects on his interest in SIM racing, offering insights into the vibrant community and its role in shaping his skills and competitiveness. As the conversation unfolds, Will delves into his racing aspirations and goals for the upcoming season, drawing inspiration from fellow British drivers like Lando Norris and George Russell. He shares his predictions for the F1 season and his thoughts on McLaren's performance, showcasing his keen insights into the motorsport landscape. The episode takes a personal turn as Will shares his experiences with F1 memorabilia, his admiration for Max Verstappen's driving style, and his most embarrassing moment at a race—a testament to his willingness to learn and grow from every experience. Will's personality shines through in the rapid-fire round, where he offers quick-fire responses on topics ranging from social media platforms to his interests outside of racing. He opens up about his friendships with fellow drivers, the importance of camaraderie in racing, and his dedication to continuous improvement on the track. This episode isn't just about racing; it's a window into the life and passions of a young driver on the rise. Will Macintyre's journey, from his racing aspirations to his off-track hobbies and friendships, offers a captivating glimpse into the multifaceted world of motorsport. Hit that subscribe button and turn on notifications so you never miss an episode of Track Limits. Share your thoughts in the comments below, and let us know what inspires you about Will's incredible journey! Here are Will's socials so you can follow him on his journey: https://www.instagram.com/williammacintyre_official/ https://www.x.com/williammacintyre_official Make sure to subscribe, review and follow us on our socials: https://www.instagram.com/tracklimits/ https://twitter.com/tracklimits_pod/ https://www.tiktok.com/@tracklimitspod Join our mailing list to learn more about Track Limits: https://www.tracklimitspod.com/ We have launched our MERCH STORE with some exclusive items. Unlock free shipping worldwide using the code FREESHIPPING at https://shop.tracklimitspod.com Don't forget to subscribe to our channel, hit the notification bell, and leave a comment. Learn more about your ad choices. Visit megaphone.fm/adchoices
We are absoultely blessed to have an amazing and humble Nayab Sultan join us on the Conversation this week. Genuinely one of the biggest honours I have had to speak to someone who has achieved so much to help humanity. Just listen. That''s all I can say. Just listen.Dr. Nayab Sultan is a certified Health, Safety, Industrial Hygiene, and Environmental Sciences Professional with licenses in Occupational Medicine1. He has over 35 years of global experience across 60 countries and several sectors including construction, engineering, mining, tunnelling, oil and gas, process industries as well as trade unions and governmental and non-governmental organizations.During his extensive career, he has worked with organizations of all types ranging from global leaders to small family-run businesses2. His clients have included ABB, Saudi Aramco, Shell, BP, British Coal Board, Tata Steel, Imperial College London, Jaguar Landrover, Dubai Dry Docks, Georgia Pacific (Pulp and Paper), Fujitsu, Canadian Union of Public Employees (CUPE1978, Victoria), Capital Regional District, Metro Vancouver, Tuvalu Seafarers Union, and the Ministry of Labour, Government of Uganda.Dr. Sultan is currently a Research Fellow at the University of Birmingham in the Geography, Earth, and Environmental Sciences department3. He is also an Examiner for the National Examinations Board for Occupational Safety and Health in Leicester, GB3. He serves on the Research and Ethics Committee at the Pacific Coast University for Workplace Health Sciences in Port Alberni, British Columbia, Canada.He has also been a Visiting Professor at the University of Malawi's School of Applied Sciences, Department of Environmental Health3. He has been a Course Reviewer and Instructor, and a Course Developer at the Pacific Coast University for Workplace Health Sciences.Dr. Sultan holds a PhD in Occupational Health, Safety, and the Environment from the University of Birmingham3. He also has a Master of Research (MRes) from the University of Hull, and an M.Sc. in Occupational Health, Safety, and the Environment from the University of Birmingham3. He completed his M.Phil by Research at the University of the West Indies.He is an international expert in work-related ill-health and occupational diseases, and a subject matter expert in Silica Dust Management, Silicosis, and Silica-Induced Diseases.Dr. Sultan is a member of several professional organizations including the South African Society of Occupational Medicine (SASOM), the Canadian Society of Safety Engineering, the International Commission on Occupational Health, and the Institution of Occupational Safety and Health.LinkedIn: https://www.linkedin.com/in/nayabsultan/Website: http://www.global-hse.com/YouTube: https://www.youtube.com/@drnayabsultan Thanks for listening. We have some great guests coming up in future pods so get ready to learn. Until next time, enjoy the rest of your week, and stay safe. https://plus.acast.com/s/health-and-safety-conversations. Hosted on Acast. See acast.com/privacy for more information.
2023 GB3 champion and 2024 F3 Rodin Motorsport driver Callum Voisin joins the podcast to talk through all your burning questions. #roadtof1 #f3 #formula3 Don't forget to like this video and subscribe to the channel! Who says junior single-seater reporting has to be boring? The F1 Feeder Series crew is here to bring you the latest on the world of feeder series, from Formula 2 all the way down to Formula 4 and everything in between. Like what you hear? Follow everyone on this podcast! Jim Kimberley X: https://twitter.com/JimKimberley Jim Kimberley Instagram: https://www.instagram.com/jimakimberley/ Callum Voisin Instagram: https://www.instagram.com/callumvoisin/ Find more from Feeder Series here! Website: https://feederseries.net Twitter: https://twitter.com/feeder_series Instagram: https://www.instagram.com/feederseriesnet
How do businesses today navigate the complex world of IT and managed network solutions while keeping pace with technological advancements and security challenges? I sit down with Alan Stephenson-Brown, CEO of Evolve Business Group, to explore this intricate landscape. Evolve, an independently owned company specializing in end-to-end IT and managed network solutions has been a trailblazer since 2005. It provides services that help businesses reduce costs, simplify service management, and allow teams to focus on their core competencies. With its umbrella of brands – Evolve, 4G Voice & Data, and GB3 – the company has become a key player in keeping networks of various industries compliant, protected, and connected. Alan Stephenson-Brown, leading Evolve since 2012, has been instrumental in the company's transformation from a Guest WiFi and connectivity provider to a powerhouse in fully managed network solutions, including best-in-class SD-WAN. Under his leadership, Evolve has expanded its reach to 11 countries, working with prominent clients like KFC, Starbucks, and BP. This episode delves into the multifaceted aspects of managed network solutions and the use of AI. Alan will shed light on how Evolve began as a guest WiFi provider and evolved into offering completely managed network solutions, the importance of AI in analyzing network alerts and data to enhance services and security, and the critical role of segregating networks and ensuring PCI compliance. Moreover, we'll explore the recent strategic acquisitions by Evolve, including 4G Voice and Data and GB3, which have doubled its headcount and expanded its services into IT, cloud, and cybersecurity. In a world where the security landscape is constantly changing and the integration of AI and IoT is becoming more prevalent, Alan offers his expert insights on the challenges and opportunities businesses face. Alan provides practical advice and solutions for businesses navigating these complexities, from the dangers lurking in back-office technologies like CCTV and printers to the impending PCI DSS V4 compliance requirements.
Polski kierowca na co dzień startujący w brytyjskiej serii GB3 będzie miał okazję zadebiutować w prestiżowej kategorii FRECA. Opowiada o tym, w 28. wydaniu audycji ,,Czas na Motorsport". Rozmowę prowadzi Piotr Nałęcz. Z wszystkimi wydaniami audycji „Czas na Motorsport” można się zapoznać tutaj. Audycja „Czas na Motorsport” w każdy wtorek o godz. 21:00 na antenie Radia Wnet. Zapraszamy!
The Traxion Podcast - Racing video games, esports and sim racing
Max Esterson grew up in New York City playing Formula 1 video games, and latterly, iRacing. He didn't kart for a decade.Yet, here's racing, and winning, in GB3 - the UK's premier single-seater championship, on the ladder to Formula 1. He aims to compete in FIA Formula 3 next season and has backing from the sim racing subscription-based platform.If you've seen the Gran Turismo Movie, well Esterson is working the sim-to-real career, but without winning a reality TV show competition. Just raw talent, guile and passion.In this episode of the Traxion.GG Podcast, Thomas Harrison-Lord is joined by Piers Prior - who is not only part of the Traxion family but co-commentates and co-presents the GB3 championship - find out what makes Esterson tick, his lofty ambitions and how iRacing has supported his efforts.If you'd like to hear more episodes like this one, please follow, like and subscribe on your podcast app of choice. If you enjoyed this episode, please leave a comment on the Traxion.GG website or a review. Your feedback is invaluable and helps us to create more episodes in the future.Latest iRacing news: https://traxion.gg/category/games/iracing/Fanatec affiliate link: https://geni.us/txn-fanatecMoza affiliate link: https://mozaracing.com/?ref=r7OBYTBC8quwTrakRacer affiliate link: https://trakracer.com/?ref=VPpUf1OAhYB0KuBuzzsprout affiliate link: https://www.buzzsprout.com/?referrer_id=1675699Follow Traxion.GGhttps://twitter.com/TraxionGGhttps://www.instagram.com/traxiongg/https://www.youtube.com/traxiongghttps://www.facebook.com/TraxionGG/The Gaming BlenderHave you ever wanted to design your own video game?Listen on: Apple Podcasts Spotify
Polski kierowca w "Czasie na Motorsport" opowiedział o swoim drugim podium w GB3, a także o zaciętej rywalizacji w brytyjskiej serii. Tymek podziękował za wsparcie zbiórki na rzecz dokończenia sezonu. Z kierowcą rozmawiają Kamil Kowalik i Piotr Nałęcz.
Tymek Kucharczyk mówi o swoim bardzo udanym weekendzie GB3 na torze Silverstone. Polak zdobył tam czwarte i trzecie miejsce. 17-latek porusza także temat dość poważnej kontuzji - mowa o złamaniu obojczyka. Kierowca mówi również o swojej zbiórce. Tymek zbiera fundusze na dokończenie sezonu. Dariusz Szymczak po raz kolejny wypowiada się na temat najważniejszych wątków ze świata Formuły 1 przy okazji Grand Prix Belgii na torze Spa - Franchorchamps. Goście programu: Tymek Kucharczyk - polski kierowca zespołu Douglas Motorsport w brytyjskiej serii GB3 Dariusz Szymczak - dziennikarz ,,Rally And Race" i ,,ŚwiatWyścigów.pl" Prowadzący: Kamil Kowalik i Piotr Nałęcz. Z wszystkimi wydaniami audycji „Czas na Motorsport” można się zapoznać tutaj. Audycja „Czas na Motorsport” w każdy wtorek o godz. 21:00 na antenie Radia Wnet. Zapraszamy!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.21.545896v1?rss=1 Authors: Wuenkhaus, D., Tang, R., Nyame, K., Laqtom, N. N., Schweizer, M., Rosato, A. S., Kroegsaeter, E. K., Wollnik, C., Abu-Remaileh, M., Grimm, C., Hermey, G., Kuhn, R., Gruber-Schoffnegger, D., Markmann, S. Abstract: Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). Activation of the lysosomal ion channel TRPML1 has previously been shown to be beneficial in several neurodegenerative disease models. Here, we tested whether TRPML1 activation rescues disease-associated phenotypes in CLN3-deficient retinal pigment epithelial (ARPE-19 CLN3-KO) cells. ARPE-19 CLN3-KO cells accumulate LAMP1 positive organelles and show lysosomal storage of mitochondrial ATPase subunit C (SubC), globotriaosylceramide (Gb3), and glycerophosphodiesters (GPDs), whereas lysosomal bis(monoacylglycero)phosphate (BMP/LBPA) lipid levels were significantly decreased. Activation of TRPML1 reduced lysosomal storage of Gb3 and SubC but failed to restore BMP levels in CLN3-KO cells. TRPML1-mediated decrease of storage was TFEB-independent, and we identified TRPML1-mediated enhanced lysosomal exocytosis as a likely mechanism for clearing storage including GPDs. Therefore, ARPE-19 CLN3-KO cells represent a human cell model for CLN3 disease showing many of the described core lysosomal deficits, some of which can be improved using TRPML1 agonists. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
GB3 championship leader Joseph Loake has had a turnaround in fortunes since first joining the podcast last year and comes on to talk about how everything has changed in his world. In this episode, we dive into: ☔️ Some very British weather ⛔️ The oddest GB4 disqualification
12-letnia Klara Kowalczyk rywalizuje w kartingowych mistrzostwach Europy. W Radiu Wnet opowiada o swoim nowym, zasłużonym zespole CRG, o swoim idolu - Jemesie Huncie - i celach na dalsze lata kariery. Gościem "Czasu na Motorsport" jest także Krzysztof Kowalczyk - członek Komisji FIA ds. Mistrzostw Elektrycznych i Nowej Energii. Nasz gość wyjaśnia, co oznacza dyrektywa unijna zakazująca rejestrowania po 2035 roku samochodów innych od tych z napędem elektrycznym lub spalinowym, ale napędzanym e-paliwem. Krzysztof Kowalczyk opowiada także o działaniach swojej komisji i przyszłości jednostek napędowych w motorsporcie. Kartingowe wydanie audycji nie mogłoby się odbyć bez Pawła Surynowicza. Naczelny "Polskiego Kartingu" śpieszy z doniesieniami ze świata "czystego ścigania" - tak doświadczeni kierowcy zwykli wspominać rywalizację w kartingu. W audycji także omówienie początku przygody Tymka Kucharczyka z serią GB3. Goście programu: Klara Kowalczyk - uczestniczka kartingowych mistrzostw Europy i FIA Karting Academy Trophy, Krzysztof Kowalczyk - członek Komisji Międzynarodowej Federacji Samochodowej ds. Mistrzostw Elektrycznych i Nowej Energii, Paweł Surynowicz - redaktor naczelny "Polskiego Kartingu". Prowadzący: Kamil Kowalik i Piotr Nałęcz. Z wszystkimi wydaniami audycji „Czas na Motorsport” można się zapoznać tutaj. Audycja „Czas na Motorsport” w każdy wtorek o godz. 22:00 na antenie Radia Wnet. Zapraszamy!
Today we have a very special guest, Luke Browning, who is one of the rising stars in motorsport. Luke recently made headlines by winning the prestigious Aston Martin Autosport BRDC Young Driver Award, which recognizes the most promising young drivers in the UK. He also recently joined the Hitech team for the start of the 2023 FIA F3 season. On the podcast he talks about his experiences battling to win the championship in GB3, his journey to winning our young driver award, and how he's approaching 2023 on the F3 grid. Learn more about your ad choices. Visit megaphone.fm/adchoices
Santino Ferrucci has a more than 10-year history of racing single-seaters. He climbed the ranks through F3 Euro, British F3, and GB3 to become the development driver in #F1 for Haas. 2018 saw the start of his INDYCAR SERIES journey with Dayle Coyne Racing and he's been with a number of outfits with some calling him the Nico Hulkenberg of IndyCar or the Super Sub. Chatting to Connor Jackson and James Scott he reveals what life is like nowadays and what he does away from the race track. Motorsport Radio has live INDYCAR race coverage all season of the NTT INDYCAR SERIES. https://motorsport.radio/nowplaying/ #indycar #indycarseries #SantinoFerrucci
Santino Ferrucci has a more than 10-year history of racing single-seaters. He climbed the ranks through F3 Euro, British F3, and GB3 to become the development driver in #F1 for Haas. 2018 saw the start of his INDYCAR SERIES journey with Dayle Coyne Racing and he's been with a number of outfits with some calling him the Nico Hulkenberg of IndyCar or the Super Sub. Chatting to Connor Jackson and James Scott he reveals what life is like nowadays and what he does away from the race track. Motorsport Radio has live INDYCAR race coverage all season of the NTT INDYCAR SERIES. https://motorsport.radio/nowplaying/ #indycar #indycarseries #SantinoFerrucci
Santino Ferrucci has a more than 10-year history of racing single-seaters. He climbed the ranks through F3 Euro, British F3, and GB3 to become the development driver in #F1 for Haas. 2018 saw the start of his INDYCAR SERIES journey with Dayle Coyne Racing and he's been with a number of outfits with some calling him the Nico Hulkenberg of IndyCar or the Super Sub. Chatting to Connor Jackson and James Scott he reveals what life is like nowadays and what he does away from the race track. Motorsport Radio has live INDYCAR race coverage all season of the NTT INDYCAR SERIES. https://motorsport.radio/nowplaying/ #indycar #indycarseries #SantinoFerrucci
Gościem specjalnym "Czasu na Motorsport" jest Tymek Kucharczyk - 17-letni kierowca rozpoczynający swoje starty w brytyjskiej serii GB3. W audycji rozmawiamy także o F1 - gościem Dariusze Szymczak. Tymek Kucharczyk opowiada o swoich pierwszych odczuciach z jazdy bolidem GB3. Gość audycji mówi, jak zapatruje się na rywalizację w nowej serii, w której będzie się ścigał m.in. na słynnym Silverstone, Spa czy Donington Park. W rozmowie z Dariuszem Szymczakiem omawiamy m.in. przyszłość rywalizacji między duetem Red Bulla - Maxem Verstappenem i Sergio Pérezem. Wysłuchaj całej audycji: Goście programu: Dariusz Szymczak - dziennikarz "Rally and Race" i "ŚwiatWyścigów.pl" Tymek Kucharczyk - kierowca wyścigowy zespołu Douglas Motorsport w serii GB3, trzeci kierowca Hiszpańskiej Formuły 4 w sezonie 2022, członek Akademii Orlenu. Prowadzący: Piotr Nałęcz i Kamil Kowalik. Z wszystkimi wydaniami audycji „Czas na Motorsport” można się zapoznać tutaj. Audycja „Czas na Motorsport” w każdy wtorek o godz. 22:00 na antenie Radia Wnet. Zapraszamy!
Bienvenue sur RARE à l'écoute, la chaîne de Podcast dédiée aux maladies rares. Pour ce deuxième épisode sur la maladie de Fabry, nous recevons le Pr Bertrand Knebelmann, néphrologue au sein du service de néphrologie dialyse adulte de l'hôpital Necker-Enfants Malades à Paris, et responsable adulte du centre de référence maladies rénales héréditaires de l'enfant et de l'adulte (MARHEA). Nous abordons aujourd'hui les conséquences rénales et cardiaques de la maladie de Fabry, les symptômes rénaux et cardiaques évocateurs de la maladie, les conséquences de l'évolution de la maladie sur le rein et le cœur, ainsi que la prise en charge de ces atteintes. Si vous désirez vous informer et aller plus loin dans la connaissance de cette pathologie, nous vous donnons rendez-vous sur notre site internet www.rarealecoute.com. L'orateur n'a reçu aucune rémunération pour la réalisation de cet épisode. Invité : Pr Bertrand Knebelmann – Hôpital Necker-Enfants Malades – Paris https://www.aphp.fr/service/service-38-061 https://www.filiereorkid.com/crmr_marhea/ L'équipe : Virginie Druenne - Programmation Cyril Cassard - Animation Hervé Guillot - Production Crédits : Sonacom
In a break from our regular programming, we actually talk Formula One on the F1 Feeder Series podcast with Dudu Barrichello on the grid at the #brazilgp, Alex Dunne supporting the #abudhabigp, and Maria Clara Castro being an #f1 social media celebrity! In this episode, we dive into:
A Fórmula 1 está de volta à Ásia, com o GP de Singapura, 17ª etapa dpo campeonato, em corrida que pode dar o bicampeonato a Max Verstappen, dependendo de uma série de resultados.O Q4 analisa tudo o que rolou em Marina Bay no treino que define o grid de largada para a corrida de domingo. O programa terá convidados mais do que especiais, como o jornalista dos canais ESPN, Thiago Alves, e do piloto Roberto Faria, da GB3 e que busca vaga na F3 em 2023.#F1 #Motorsport #F12022
Dino Beganovic and Joel Granfors are here to talk about their excellent 2022 seasons, meaning we probably have the next Swedish F1 driver on this week's podcast! With both drivers leading their championships, we dive into:
Bent Viscaal – Formula 2's other Dutch 2021 hopeful – and GB3's Nick Gilkes join in the podcasting fun to digest the news that Formula 2 and Formula 3 are heading down under to Oz, how Aron is back in contention in FRECA, and answer all your questions about their careers In this episode we dive into:
Die Brainwashed - Radio Edition ist eine einstündige Show mit Musik von den Künstlern und Labels auf Brainwashed.com. 1. A Place To Bury Strangers, "Let's See Each Other" (See Through You) 2021 Dedstrange 2. Joseph Allred, "Six Miles up the Obey River" (Six Miles up the Obey River/A Great Yellow Poplar) 2021 Future Grave 3. Cassetteboy, "Crap Boasts" (Carry On Breathing) 2008 Barry's Bootlegs / 2020 self-released 4. Rude Skøtt Osborn Trio, "L'Ombra Blu" (The Virtue of Temperance) 2022 El Paraiso 5. Lennert Jacobs, "The Mission" (Enthusiasm) 2021 les albums claus 6. Treasury of Puppies, "The Treasury of Puppies" (Treasury of Puppies) 2020 self-released 7. homeshake, "Feel Better" (Under The Weather) 2021 Sinderlyn 8. Tanz Mein Herz, "Tales from the middle of the night" (Quattro) 2021 Standard in-Fi 9. Tirzah, "Tectonic" (Colourgrade) 2021 Domino 10. GB3 (feat. Steve Kilbey), "Sakura Flower" (Sakura Flower) 2021 self-released 11. Emeka Ogboh, "Everydaywehustlin" (Beyond The Yellow Haze) 2021 Ostgut Ton 12. Lisa Germano, "Diamonds" (No Elephants) 2013 Badman # Brainwashed - Radio Edition Email podcast at brainwashed dot com to say who you are; what you like; what you want to hear; share pictures for the podcast of where you're from, your computer or MP3 player with or without the Brainwashed Podcast Playing; and win free music! We have no tracking information, no idea who's listening to these things so the more feedback that comes in, the more frequent podcasts will come. You will not be put on any spam list and your information will remain completely private and not farmed out to a third party. Thanks for your attention and thanks for listening. * http://brainwashed.com
Formula 2 says Vamos to Felipe Drugovich after the Brazilian became the first driver to win both races in a weekend since GP2 became F2. We have Mari Boya and Roberto Faria help us unpack Felipe's brilliant weekend and talk about their FRECA & GB3 campaigns. In this episode we dive into:
Williams Racing's Zak O'Sullivan and GB4 newcomer Logan Hannah join the F1 Feeder Series Podcast this week ahead of the opening GB3 race at Oulton Park. We get ready for the British Formula season this episode by diving into:
Join Danny Marang as he takes a look at the Portland Trail Blazers' 3rd straight loss of 30 points or more with Wednesday night's defeat coming at the hands of the Phoenix Suns, 120-90. Long story short, this is what you can expect for the remainder of the season. The Blazers don't have the talent (purposefully) right now to compete. It's very clear that the team is looking to get the best odds possible to get into the top 4 of the NBA Draft. However, in every night there will be glimpses to enjoy. Normally, it will be the play of Anfernee Simons - pulling up off the bounce, getting down hill and hitting an unreal floater or ripping a one-handed pass to the second-side corner. Other times, like tonight, you'll see Trendon Watford put together a stat line; 13 points, 7 rebounds, 6 assists that makes you raise an eyebrow about what he could be down the road. Then there's the much more in your face example of Greg Brown III absolutely banging on JaVale McGee that makes you want to tune in for GB3's every minute. So tune into the Jacked Ramsays and make sure you're covered each and every game! SUBSCRIBE: YouTube, Twitch, Apple Podcasts, Spotify, Google and Anywhere You Get Podcasts! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Two years into the pandemic, the tired narrative of legacy media & public health authoritarians like Fauci, has almost completely reversed from driving fear of the Covid, to ‘we must learn to live with this virus'. So why have Fauci & Co. made such an abrupt ‘about face?'#GreatBarringtonDeclaration #GBD #GB3
The four finalists who will contest the 2021 Aston Martin Autosport BRDC Young Driver of the Year Award have been selected. Ollie Bearman, Jonny Edgar, Louis Foster and Zak O'Sullivan are the finalists. None have been in the Award before. This week on the podcast we're talking to each driver individually, and hearing about their story so far. Previous winners include 2009 F1 world champion Jenson Button, 13-time grand prix winner David Coulthard, current F1 drivers Lando Norris and George Russell, triple Indianapolis 500 winner Dario Franchitti, and 2014 World Endurance champion Anthony Davidson. Today we're talking to Zak O'Sullivan. O'Sullivan has been the driver to beat in GB3 this year. The 16-year-old continued the impressive form from his first single-seater campaign last season, when he came oh-so-close to securing the British F4 crown. He seems set to make up for that disappointment this year, as he comfortably tops the points ahead of the finale.
The four finalists who will contest the 2021 Aston Martin Autosport BRDC Young Driver of the Year Award have been selected. Ollie Bearman, Jonny Edgar, Louis Foster and Zak O'Sullivan are the finalists. None have been in the Award before. This week on the podcast we're talking to each driver individually, and hearing about their story so far. Previous winners include 2009 F1 world champion Jenson Button, 13-time grand prix winner David Coulthard, current F1 drivers Lando Norris and George Russell, triple Indianapolis 500 winner Dario Franchitti, and 2014 World Endurance champion Anthony Davidson. Today we're talking to Ollie Bearman. The 16-year-old Essex driver has been the class of the ferociously competitive Italian and German Formula 4 championships in 2021. Bearman has won 13 races with Van Amersfoort Racing and leads the points in both series. Has also been a race winner in selected GB3 outings, despite limited mileage compared to his rivals.
Episode 549: November 28, 2021 playlist: A Place To Bury Strangers, "Let's See Each Other" (See Through You) 2021 Dedstrange Joseph Allred, "Six Miles up the Obey River" (Six Miles up the Obey River/A Great Yellow Poplar) 2021 Future Grave Cassetteboy, "Crap Boasts" (Carry On Breathing) 2008 Barry's Bootlegs / 2020 self-released Rude Skott Osborn Trio, "L'Ombra Blu" (The Virtue of Temperance) 2022 El Paraiso Lennert Jacobs, "The Mission" (Enthusiasm) 2021 les albums claus Treasury of Puppies, "The Treasury of Puppies" (Treasury of Puppies) 2020 self-released homeshake, "Feel Better" (Under The Weather) 2021 Sinderlyn Tanz Mein Herz, "Tales from the middle of the night" (Quattro) 2021 Standard in-Fi Tirzah, "Tectonic" (Colourgrade) 2021 Domino GB3 (feat. Steve Kilbey), "Sakura Flower" (Sakura Flower) 2021 self-released Emeka Ogboh, "Everydaywehustlin" (Beyond The Yellow Haze) 2021 Ostgut Ton Lisa Germano, "Diamonds" (No Elephants) 2013 Badman Email podcast at brainwashed dot com to say who you are; what you like; what you want to hear; share pictures for the podcast of where you're from, your computer or MP3 player with or without the Brainwashed Podcast Playing; and win free music! We have no tracking information, no idea who's listening to these things so the more feedback that comes in, the more frequent podcasts will come. You will not be put on any spam list and your information will remain completely private and not farmed out to a third party. Thanks for your attention and thanks for listening.
The 2021 GB3 season started out as British Formula 3, but the famous name disappeared mid-season. What was shaping up to be a tight title battle also started to change narrative at the same time, and it was Carlin's Zak O'Sullivan who triumphed in unusual circumstances. Formula Scout's GB3 correspondent Steve Whitfield joins Craig Woollard to discuss the season at length and what the future holds for it and for its new feeder series GB4. Stick around at the end for Steve's chat with the champion after he was crowned at Donington Park
The four finalists who will contest the 2021 Aston Martin Autosport BRDC Young Driver of the Year Award have been selected. Aston Martin joined the Award in 2019. Previous winners include 2009 F1 world champion Jenson Button, 13-time grand prix winner David Coulthard, current F1 drivers Lando Norris and George Russell, triple Indianapolis 500 winner Dario Franchitti, and 2014 World Endurance champion Anthony Davidson. Kevin Turner (Chief Editor, Autosport) is joined by Marcus Simmons and Ian Titchmarsh to discuss why these are four finalists. German and Italian Formula 4 points leader Ollie Bearman, FIA F3 racer Jonny Edgar, Euroformula Open title contender Louis Foster and GB3 championship favourite Zak O'Sullivan are the finalists. None have been in the Award before. The winner will be announced at the Autosport Awards on 19th December.
Conquistando a segunda vitória seguida na temporada 2021 da IMSA, a dupla brasileira Pipo Derani e Felipe Nasr entrou de vez na briga pelo título do principal campeonato de endurance da América do Norte. Neste episódio do Podcast Mundo Afora, os jornalistas especializados Alexander Grünwald, Leonardo Marson e Felipe Giacomelli analisam as chances dos pilotos do protótipo Cadillac em busca do título, e comentam também a possível transferência de Nasr para a o programa Penske Porsche no novo regulamento LMDH. No segundo bloco, o tema é a MotoE, que tem o brasileiro Eric Granado em busca da liderança do campeonato. A categoria de motos elétricas corre na programação da MotoGP neste fim de semana, na Áustria. Os jornalistas comentam ainda a conturbada prova da Fórmula Indy em Nashville e as chances do brasileiro Roberto Faria na GB3 (novo nome da F3 Britânica). Roteiro: Ana Oliveira. Edição: Roberto Knorr. Arte: Rica Ramos.
Craig Woollard and Bethonie Waring discuss the rebranding of the BRDC British Formula 3 championship to GB3 with immediate effect and the implications going forward. In addition, Dan Ticktum leaves the Williams Academy amid controversial comments, and FIA Formula 3 and British Formula 4 were in action in the rain over the weekend.
Pharma Bro & the reporter: A love story. GB3 has reopened despite public health measures saying they're not supposed. Listeners comment. Hibernating may have been the key to the survival of early humans. See omnystudio.com/listener for privacy information.
Creeping up on the end of the year, GB3 decides to open its doors tomorrow. Listeners comment and ask questions about the COVID-19 vaccine. Fri 12/18: Hour 1 See omnystudio.com/listener for privacy information.
On today’s show the guys talk two new trailers to drop this week, Wonder Woman and Ghostbusters Afterlife. Tune in and see what the guys have to say about these highly anticipated films. DM us on Instagram @recpodcast
Both Andy and Desiree came from blue collar families. Desiree is originally from Arizona and comes from an extremely small town of approximately 30,000 people. As a result, coming to the Fresno area was extremely overwhelming for her. Andy is a mountain boy that grew up in Bass Lake, CA. Just about the time he was going to graduate from Fresno State University, he eventually made the move to Fresno, CA. They met while they both were attending college at Fresno State University. Desiree got her Bachelors degree in Psychology and she did college advising for a few years. Andy studied Fine Art, however he quickly realized that his degree wouldn't really give him the opportunity to line up a good job right after graduating college. So, he ended up double majoring in GIS, which led to a job in waste water treatment for about 10 years. As a stay at home mom, Desiree began teaching Yoga at GB3 (a local gym) a few nights a week. She talks about how stressful and vulnerable it was to get up in front of people and guide them through a very structured practice. There were lots of times where she would just go home crying in her car. Even though it was rough at first, she continued to push through it. And through this she realized that she wanted to teach more and more. She absolutely loved the community of people that yoga was allowing her to be around and wanted to find a way to get more of that community on a regular basis. Desiree and Andy talk a lot about all the obstacles that come with being in business with your spouse. They talk about how opening up their first studio, took a big toll on their relationship. However, their success has come from constantly supporting each other through the thick and thin times. Listen carefully, because they share some great insights about being in business with your spouse. Despite everything they have been through, they have found a way to work through it together and have come out on top. You can feel how genuinely these two amazing people love and care for each other. Their story is amazing and we hope that you enjoy it. Please reach out to either of us if there is ever anything that we can do for you or if you would just like to connect with us. And as always, please like, rate, review, and share the podcast so that we can reach more people with the stories of amazing Entrepreneurs like Andy & Desiree! - Old Town Yoga Website: https://www.oldtownyogastudio.com/ - FB: https://www.facebook.com/desiree.manzanaresheckman | https://www.facebook.com/profile.php?id=100008302814699 | https://www.facebook.com/IsaiahdTrejo - IG: https://www.instagram.com/desi__rose/ | https://www.instagram.com/art.of.andy/ | https://www.instagram.com/isaiahdtrejo/
In this podcast I pay a visit to Gracie Barra Fulham (again) to talk to Brazilian Black Belt (Gracie Barra) Professor. Guilherme Trestini. The previous night to this, I met Guilherme for the first time at GB West Kensington, the night before we recorded and participated in his GB1 class. I thoroughly enjoyed myself and really got on well with him. He invited me to GB Fulham the next day for a GB3 class. It was an amazing experience that I managed to top off by firstly having a 6 minute spar with him, followed by recording a podcast episode to get his story. We discussed his journey so far, including his move over from team Carlson Gracie to Gracie Barra to teach at GB Fulham with Lagarto. We also discuss his ongoing acting career and his surprising lack of ability to be able to surf. Bizarre, as common stereo types would have us believe the opposite if you are originally from Rio and do BJJ. You couldn't meet a nicer guy. Both Guilherme and Lagarto complement each other so well as the master and the student which reflects well when Guilherme teaches as he carries such authority. It's hard to believe he's only 28. Watch out for this guy. Enjoy.
Uh I assume that you're EXCITED for GB3 but you know what happens when you ASSUME! In this episode we'll talk about the controversy with the GB3 trailer and what other movies we were stoked to see. Of course we'll also hit the classics with Just Preesh Play, Any Blu You Can Do, and Coming Attractions as always! Music tracks below: Four, Floss, Five, Six By Blue Ducks Destination by Anitek Spot Rockers (Cuervo Gold Instrumental) by Cassette Tape Bandits So On And Yo! (D.A.I.S.Y. Age Instrumental) by Lowdown D34D 5P4C3 (VIP Mix) by Strong Suit Lyrikal Tranzportashun By Lowdown BugaBlue By US Army Bluest
Uh I assume that you're EXCITED for GB3 but you know what happens when you ASSUME! In this episode we'll talk about the controversy with the GB3 trailer and what other movies we were stoked to see. Of course we'll also hit the classics with Just Preesh Play, Any Blu You Can Do, and Coming Attractions as always! Music tracks below: Four, Floss, Five, Six By Blue Ducks Destination by Anitek Spot Rockers (Cuervo Gold Instrumental) by Cassette Tape Bandits So On And Yo! (D.A.I.S.Y. Age Instrumental) by Lowdown D34D 5P4C3 (VIP Mix) by Strong Suit Lyrikal Tranzportashun By Lowdown BugaBlue By US Army Bluest
'IT'S ERIK NAGEL' Call The Show [24/7]: +16517648437 INTRO [0:00:00] Intro SEGMENT 01 [0:03:23] Arctic freeze hits the Northeast. Stomach virus going around. Trevor feels 'Grape' is the worst flavor. Trevor's issues at Disney World. BREAK [0:56:24]www.ihatestevensinger.com SEGMENT 02 [1:00:28] Box Office updates. 'Clerks' 25th anniversary. 'The Sopranos' movie updates. 'Ghostbusters 3' updates. Leslie Jones upset at GB3. TV updates. 'Fyre Festival' documentaries. BONUS TIME [1:58:00] HEAR 'IT'S ERIK NAGEL' ON: IHEARTRADIO | ITUNES | STITCHER | GOOGLEPLAY | SPOTIFY | TUNE-IN | YOUTUBE FOLLOW 'IT'S ERIK NAGEL': TWITTER | INSTAGRAM | FACEBOOK | WEBSITE |
On this episode of Deech N Dash: Jordy Lee is back on the GTN and ready for action as he sits down with #GB3 member and good deech "The Real" Brock Hall! Facebook: www.facebook.com/thegrappletalk Twitter: www.twitter.com/thegrappletalk Email: grappletalkpodcast@gmail.com
Ahead on Biotechnology Focus Radio : Bellus Health back in the game with a new therapeutic asset, BC Cancer Agency scientists make two breakthrough discoveries, and RepliCel Life Sciences gets by with a little help from its friends. We have this and more in store for you on this week’s show. Welcome to another episode of Biotechnology Focus Radio. I’m your host Shawn Lawrence, here to give you a rundown of this week’s top stories on the Canadian biotech scene. Our first story this week takes us to CALGARY, AB where a team of Canadian physicians and researchers are believed to be the first in the world to have used gene therapy to treat a patient with Fabry disease, a rare inherited enzyme deficiency that can damage major organs and shorten lifespan. Specifically, people with the disease have a gene called GLA that doesn’t function as it should; as a result their bodies are unable to make the correct version of a particular enzyme that breaks down a fat called Gb3. A buildup of Gb3 can lead to problems in the kidneys, heart and brain. In their experimental trial, the researchers led by Dr. Aneal Khan, a Alberta Health Services medical geneticist and member of the Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary collected a quantity of a Fabry patient’s own blood stem cells then used a specially engineered virus to augment those cells with copies of the fully functional gene that is responsible for the enzyme. The altered stem cells were then transplanted back into the patient on Jan. 11, 2017. While Dr. Khan says it’s too soon to say whether this therapy will ultimately be a long-term treatment for the disease, based on the team’s success in animal trials, he is hopeful it will be a beneficial to patients Dr. Jeffrey Medin, a researcher with the Medical College of Wisconsin and the project’s principal investigator, adds that the trial is a major step forward in treating inherited genetic diseases in adults. The treatment, which has been approved by Health Canada for experimental purposes, is also believed to be the first trial in Canada to use a lentivirus in gene therapy. In this case, the specially modified virus was stripped of its disease-causing capability and augmented with a working copy of the gene that’s responsible for the missing enzyme. The project is being funded by the Canadian Institutes of Health Research and the Kidney Foundation of Canada. The Queen Elizabeth II Health Sciences Centre in Halifax and the University Health Network in Toronto are also recruiting people with Fabry disease for the trial. In R&D news, a team of BC Cancer Agency scientists has made two exciting drug discoveries that could potentially allow for new approaches to target various cancers more specifically, through the exploitation of mutations found only in cancer cells and not normal cells. The first discovery, which has already led to a clinical trial, exploits the inability of BRCA1/2 deficient cancers to repair their own DNA. The second discovery is of a drug-like molecule that can alter the way cells translate genetic information into proteins. Both discoveries were made by Dr. Sam Aparicio, head of the Department of Breast and Molecular Oncology, and his research team at the BC Cancer Agency.The first success in this area is a discovery published in Nature Communications, where Dr. Aparicio’s team has discovered that the drug, CX-5461, originally developed for cancers of the blood and lymph system, can be repurposed as a drug treatment for breast cancer. Still early in its clinical development life cycle, CX-5461 has been shown through Dr. Aparicio’s latest work, to bind to the DNA of certain regions of the genome causing it to fold up and interrupt the DNA copying process. Thus, the compound is selectively active in tumours from patients with mutations in the BRCA1/2 gene, known to cause a strong familial predisposition to breast cancer, and account for approximately 15 per cent of the population with the disease. The study is currently in Phase 1 of a multi-centre clinical trial coordinated by Canadian Cancer Trials Group, which began in June of 2016. Phase two will accept even more patients to determine whether the activity found through preclinical studies is reflected in responses in patients. Both Dr. Aparicio and Dr. Karen Gelmon, senior scientist, medical oncologist and the clinical trial lead for the study add that if the trial is successful, they then hope to expand testing to other types of cancer in the near future. In addition to the CX-5461 findings, a second paper published in Nature Communications communicates the discovery of a different prototype drug, a compound called ‘T3’, engineered to alter the way that cells translate DNA, through splicing of RNA, into proteins. According to the researchers, this small, yet highly-potent drug-like molecule, currently in lab-testing, is being used to understand how different breast cancer cells might be susceptible to having RNA splicing interrupted. The drug molecule interferes with the molecular machinery that stiches gene sequences together to make fully functional proteins. Mutations in RNA splicing genes and defects in splicing have been found in diverse cancers, including breast cancer. The prototype drug molecules are allowing Dr. Aparicio and his team to seek out situations where cancer cells are uniquely susceptible to interference with RNA splicing. As alluded to, both drug development studies are currently centered in breast cancer treatment, but hope to expand to other types, including prostate and ovarian. Dr. Aparicio and his team’s work was supported with strategic funding from the BC Cancer Foundation. In Business new, two European firms are teaming up with Vancouver based regenerative medicine company, RepliCel Life Sciences Inc.to assist RepliCel in getting its commercial-grade RCI-02 dermal injector prototypes manufactured and tested. One of the partnering firms, AMI, is an Austrian manufacturer of medical technology based near the shores of Lake Constance, within easy reach of Germany and Switzerland. AMI develops, manufactures and distributes their medical products throughout the world. All of them are made according to the highest quality standards and enable doctors to take even better care of their patients. The second partner, Art of Technology (AoT), is based in Zurich Switzerland and is an independent contract developer specializing in the design, development and miniaturization of complex customer specific electronic devices and embedded systems for use in industrial, medical and space applications. The RCI-02 injector itself was designed with input from dermatologists, industrial designers, and electronic and medical device engineers to improve the delivery of a variety of injectables in a controlled, precise manner, removing the risks and uncertainties of injection outcomes currently resulting from manually operated, single-needle syringes. According to RepliCel president and CEO, Lee Buckler, it is the world’s first motorized injection device with programmable depth and volume, a built-in Peltier element for pre-injection anaesthetising, and interchangeable needle head configurations. It is designed to deliver a variety of injectable substances including cells, dermal fillers, drugs or biologics intradermally (dermis), subcutaneously (fat) or intramuscularly (muscle) via an array of needle configurations ranging from a single needle to a 16 needle configuration (4×4) on one head. Buckler adds that the execution of these agreements covers what RepliCel believes to be the final stages needed to prepare RCI-02 for a market authorization application in the form of a CE mark in Europe. The company hopes to have the device ready for a CE mark application and in the hands of a licensing and commercial partner next year. Our next story takes us to the Maritime provinces where the Terry Fox Research Institute is investing $5-million in support of New Brunswick researchers and their colleagues at other cancer centres in Canada to study how new precision medicine tools could improve, and potentially save the lives of patients diagnosed with the incurable cancer of the blood and bone marrow, known as multiple myeloma. The initiative is known as the Multiple Myeloma Molecular Monitoring (M4) Study, and Dr. Tony Reiman, a medical oncologist and professor at the University of New Brunswick, will lead the team, which comprises researchers and clinicians at multiple sites including Vancouver, Calgary, Toronto and Montreal. Dr. Reiman says that he hopes the five-year study will result in game-changing new approaches to identifying, treating and monitoring the disease in patients, including those who are at high risk of relapse. His team in Saint John will organize all the participating centres as well as conduct its own research and receive and bank specimens (blood and marrow) from the 250 myeloma patients that will participate in the project. Additionally, M4 study team members will use tests based on advanced techniques like immunoglobulin gene sequencing, multiparameter flow cytometry, PET scans, circulating tumour DNA analysis, and novel drug resistance assays to evaluate the patient specimens and other biosamples. Principal investigators at the partner sites are: Drs. Donna Reece and Suzanne Trudel, Princess Margaret Cancer Centre; Dr. Nizar Bahlis, University of Calgary; and Dr. François Bénard, BC Cancer Agency. Patients will be recruited by the study investigators at their own sites. Principal investigators Drs. Reece and Trudel (PM) explain their role in M4 study in the following audio. BrainStorm Cell Therapeutics Inc., a HACKENSACK, N.J.- based company developing adult stem cell technologies for neurodegenerative diseases, has signed an agreement with CCRM in the hopes of furthering its market authorization request for NurOwn®. For our new listeners, CCRM is a Toronto-based company focused on developing and commercializing regenerative medicine technologies, specifically cell and gene therapies. Through the agreement, CCRM will help Brainstorm explore opportunities to access Health Canada’s early access pathway for treatment of patients with Amyotrophic Lateral Sclerosis (ALS). If NurOwn® qualifies for Health Canada’s “Notice of Compliance with Conditions” pathway, it could be authorized in Canada for distribution in early 2018. Through the agreement, the company will work Patrick Bedford, manager of clinical translation and regulatory affairs at CCRM. Stacey Johnson (@msstaceyerin) , director, communications and marketing at CCRM and editor of Signals Blog discussed this deal recently via her regular Right Turn column Be sure to check it out at http://www.signalsblog.ca/right-turn-new-stem-cell-product-for-als-seeking-approval-in-canada/. For our final story, nearly a year since it’s failed KIACTA™ Phase 3 trial and subsequently being forced into pulling the plug on its KIACTA program, BELLUS Health is back from the brink as the Montreal-based company announced a new partnership and licensing deal with The NEOMED Institute to take over the development and commercialization activities for a potential new treatment for chronic cough. According to Bellus stakeholders,, this is a transformative transaction as this exclusive worldwide license agreement adds to the company’s pipeline a potentially best-in-class drug candidate, BLU-5937, an asset which was formerly known as NEO5937. Its development through the P2X3 antagonist program was initiated by AstraZeneca scientists in Montreal, and assigned to NEOMED in October 2012 when the NEOMED Institute was first launched. It was selected as a drug candidate to advance towards the clinic based on development efforts and extensive pre-clinical work in chronic cough done at NEOMED. According to Roberto Bellini, president and CEO of the company, the drug now going by its new name BLU-5937 will be a core focus of BELLUS’s drug development efforts. About the condition, Chronic cough is a cough that lasts eight weeks or longer and significantly impacts quality of life, with significant social (exclusion, embarrassment, difficulty speaking), physical (sleep deprivation, rib fracture, vomiting) and psychosocial (anxiety, depression) repercussions. It is estimated that in the U.S. alone, more than 2.7 million patients suffer from chronic cough that is not controlled by currently available medications. How BLU-5937 works to treat it, is it acts on a clinically validated target in the chronic cough pathway, the P2X3 receptor. Both the company and NEOMED believe BLU-5937 has the potential to become a best-in-class treatment option because of its superior potency and selectivity for the P2X3 receptor. These properties suggest BLU-5937 will be effective and less likely to cause a problematic side effect seen with less-selective drugs: taste disturbances that are significant enough to affect drug compliance. Under the terms of the agreement, BELLUS Health will pay NEOMED an upfront fee of $3.2 million, consisting of $1.7 million in cash with $1.5 million worth of BELLUS Health common shares (Approximately 5,802,177 shares). NEOMED will also be entitled to receive a royalty on net sales-based revenues. Additionally, in lieu of milestone payments, a certain portion of all other revenues received by BELLUS Health from BLU-5937 will be shared with NEOMED according to a pre-established schedule whereby the shared revenue portion decreases as the program progresses in development. Well that wraps up another episode of the Biotechnology Focus Podcast. We hope you enjoyed it. Be sure to let us know what you think, and we’re also always looking for story ideas and suggestions for future shows, and of course we’d love to hear from you as well, simply reach out to us via twitter @biotechfocus, or by email at the following email address press@promotivemedia.ca. And remember, you can also listen to past episodes online via our podcast portal at www.biotechnologyfocus.ca . For all of us here at Biotechnology Focus, thanks for listening
This week on the show, catching up on a few week's worth of news in one show! The boys talk about the recently found lost scenes including the fabled Fort Detmerring sequence, Toy Fair 2017 news including Diamond Select's Ghostbusters II announcements, Bill Murray chatting GB3, a few Answer the Call tidbits including the destiny of the Egon Spengler bust, Maurice LaMarche talks Real Ghostbusters, and the top ten reasons Ghostbusters II is an underrated classic.
(NSFW!) Guardians of the Galaxy review. Chris Pratt stole his costume. The Huntsman. Galaxy Quest is coming back. GB3 good news. Deadpool. I found the intro segment that I thought I lost! (it should've played last week, first, but now you get it this week first) Kerry and Shannon are old divas. Interview with Kristin … Continue reading "0324 – New Episode: SDCC Part, The Second"
(NSFW!) Guardians of the Galaxy review. Chris Pratt stole his costume. The Huntsman. Galaxy Quest is coming back. GB3 good news. Deadpool. I found the intro segment that I thought I lost! (it should've played last week, first, but now you get it this week first) Kerry and Shannon are old divas. Interview with Kristin … Continue reading "0324 – New Episode: SDCC Part, The Second"
(NSFW!) Cap2 by the numbers. Marvel has films planned thru 2028. TMNT casting. 12 Monkeys the series. Doom is a RocknRolla. GB3. Star Wars 7. Dr. Proctor's Fart Powder is a real movie. Santa IS a Viking. What shows will you still be watching 50 years from now? Hobbit: Smaug. The 400 blows. Lego: Hobbit. … Continue reading "0307 – New Episode fixes the Bible"
(NSFW!) Cap2 by the numbers. Marvel has films planned thru 2028. TMNT casting. 12 Monkeys the series. Doom is a RocknRolla. GB3. Star Wars 7. Dr. Proctor's Fart Powder is a real movie. Santa IS a Viking. What shows will you still be watching 50 years from now? Hobbit: Smaug. The 400 blows. Lego: Hobbit. … Continue reading "0307 – New Episode fixes the Bible"
(NSFW!)Reviews: Cloud Atlas & Wreck It Ralph. Iron Man 3 & Thor 2 spoilage. X-Men now X Director and cameo news. Joss' first new SHIELD Agent. Mad Max sequel ‘trouble'. Second Breakfast is real? Cap 2 villain? JP science can't happen. GOP vs WOW?! GB3 happnin? Apes sequel. TDKR vs Avengers. Game of Thrones. Anime … Continue reading "0232 – New Episode: No back fat for you!"
(NSFW!)Reviews: Cloud Atlas & Wreck It Ralph. Iron Man 3 & Thor 2 spoilage. X-Men now X Director and cameo news. Joss' first new SHIELD Agent. Mad Max sequel ‘trouble'. Second Breakfast is real? Cap 2 villain? JP science can't happen. GOP vs WOW?! GB3 happnin? Apes sequel. TDKR vs Avengers. Game of Thrones. Anime … Continue reading "0232 – New Episode: No back fat for you!"
Geek Shock: Where a Geek can be a Geek! Not only do we bring you the Chuck E. Cheese lament. Not only do we introduce the THOUGHT of the spawn of 80's Jeff. We also talk about Stretch Armstrong, Smallville's Arrow, Spider-man Six, EVO (Brolylegs), THE 'MERICA, ACTA, GB3, Scarlett "Money" Johansson, Fassbender's Creed, Trek 2 reveals, Ouya, Keep 32, Ear Necklaces, You're Still Here(?): The Old Republic, ISP spying and more damned SYFY shows. So spiffy up that rat, it's time for a Geek Shock!
Paul! Paul! He's a maniac. And Legos have nothing to do with it. Maybe it was the death of his beloved horse. Or his beloved fox. Either way, this week we talk about Brave dealings, Wolverine's man in jail, the anti-taser sabre, Lego maniacs, the end of the Pond, Guterson's gutter, GB3-1, Skyrim, Shatner, Sony, SOPA, Louis CK's experiment, and Foo quake. So protect your horses, it's time for a Geek Shock!
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