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In part two of this series, Drs. Shuvro Roy, Jiwon Oh, and Amit Bar-Or discuss the results of the FENhance 1 and 2 trials looking at fenebrutinib in relapsing MS. For more information, please read about the abstract that was presented at the 2026 AAN Annual Meeting. Read more about the Fenebrutinib Trial.
In part two of this series, Dr. Shuvro Roy talks with Drs. Jiwon Oh and Amit Bar-Or about the latest developments in BTK inhibitors for MS, including safety signals, trial results, and future directions. For more information, please read about the abstract that was presented at the 2026 AAN Annual Meeting. Read more about the Fenebrutinib Trial. Disclosures can be found at Neurology.org.
In part one of this series, Drs. Shuvro Roy, Jiwon Oh, and Amit Bar-Or discuss the results of the fenebrutinib trial and highlight the key takeaways that healthcare providers should be aware of. For more information, please read about the abstract that was presented at the 2026 AAN Annual Meeting. Read more about the Fenebrutinib Trial.
Could multiple sclerosis one day be detected before symptoms appear? And if so, should we be actively screening people who are at higher risk? In this episode of the ECTRIMS–MS Journal collaboration series, host Prof. Anneke van der Walt, Controversies Editor at the Multiple Sclerosis Journal, is joined by Prof. Helen Tremlett (University of British Columbia) and Prof. Ruth Ann Marrie (Dalhousie University) to debate one of the most important emerging questions in MS research. Helen argues that targeted screening should begin now—but only within carefully designed research studies—to better understand how MS develops before clinical symptoms appear. Ruth Ann argues that while prevention is the ultimate goal, the science, ethics and healthcare systems are not yet ready for widespread screening. Together they discuss: · Whether MS is entering a new era of prevention research · What lessons can be learned from Parkinson's disease and radiologically isolated syndrome (RIS) · The ethical and psychological impact of identifying people at risk before symptoms develop · How screening programmes could improve—or worsen—health inequalities · What research is still needed before screening could ever become part of routine clinical practice Although they argue opposing positions, both experts agree on one important point: preventing MS is an achievable ambition—but only if research proceeds carefully, ethically and equitably. This MS Journal Controversies article series has been made open access for the next month for ease of reading. "Yes" – High-risk populations should be screened for MS "No" – High-risk populations should not yet be screened for MS "Commentary" – High-risk populations should not yet be screened for MS Note: This episode is part of the MS Journal Controversies in MS series, where experts debate opposing viewpoints on important unresolved questions in MS research. The positions argued do not necessarily represent the authors' personal opinions, but rather present the strongest evidence supporting each side of the debate.
Welcome to the 37th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Tobias Moser of the Brain article entitled: Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial We discuss the Multiple sclerosis And DisAbility Improvement (MADAI) trial - a randomized, double-blind, placebo-controlled, single-centre, phase 2b study designed to evaluate the efficacy and safety of propionic acid as an add-on therapy in adults with clinically stable multiple sclerosis. Results show a significant impact on serum neurofilament light chain (sNfL) outcomes as well as physical and cognitive performance measures. Both relapsing-remitting and primary progressive MS was considered in this trial and the authors discuss how proprionic acid may affect neuroinflammation and neurodegeneration. Check out the full article on the Brain website as part of the July 2026 issue (editors choice): https://doi.org/10.1093/brain/awag099 This episode was co-hosted, edited and produced by Xin You Tai and Alasdair Coles, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.
In part one of this series, Dr. Shuvro Roy talks with Drs. Jiwon Oh and Amit Bar-Or about recent multiple sclerosis clinical trial data. For more information, please read about the abstract that was presented at the 2026 AAN Annual Meeting. Read more about the Fenebrutinib Trial. Disclosures can be found at Neurology.org.
During his fellowship in the United States, Dr. Avinash Chandra trained to become an MS specialist at a world-class MS center. Then he returned home to Nepal and discovered that MS was largely considered non-existent. But Dr. Chandra knew it wasn't. In this week's episode, Dr. Chandra discusses his experience creating a framework for MS care in Nepal that hadn't existed before. He also explains the necessary trade-offs in providing costly medical treatment in a country where the average family of four lives on an income of $500 a month. It's been well-established that males living with MS tend to experience faster and more severe disease progression than females. We're sharing results of a study that shows clear differences in healthcare use by sex up to a decade before the onset of MS. We'll tell you about a newly published review of 30 years of data measuring the efficacy of autologous hematopoietic stem cell transplantation (aHSCT). And we're sharing the registration details for ECTRIMS Community Patient Day (it's a free live and online event you won't want to miss!) We have a lot to talk about! Are you ready for RealTalk MS??! This Week: MS care in a country that considered MS non-existent :22 A study analyzed sex differences in healthcare usage between males and females with MS up to a decade before the first MS symptom develops 1:45 30 years of accumulated data show significant benefits of autologous hematopoietic stem cell transplantation in treating relapsing forms of MS 6:17 It's time to support the National MS Society's $119.6 million active investment in MS research 9:32 Dr. Avniash Chandra discusses MS care in Nepal 12:43 Share this episode 35:40 Next week 36:01 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/465 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com STUDY: Sex Differences in Healthcare Use Before the First Multiple Sclerosis-Related Demyelinating Event https://www.msard-journal.com/article/S2211-0348(26)00396-2/fulltext PLAIN ENGLISH SUMMARY: Sex Differences in Healthcare Use Before the First Multiple Sclerosis-Related Demyelinating Event https://tremlettsmsresearchexplained.wordpress.com/2026/07/22/sex-differences-in-healthcare-use-before-the-first-multiple-sclerosis-related-demyelinating-event-explained LISTEN: Dr. Helen Tremlett Discusses the MS Prodrome https://realtalkms.com/321 STUDY: Autologous Stem Cell Transplantation for Multiple Sclerosis https://pubmed.ncbi.nlm.nih.gov/41482159 REGISTER: ECTRIMS Patient Community Day https://ectrimspatientcommunity.eu SUPPORT: National MS Society Research https://nationalmssociety.org/research JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 465 Guest: Dr. Avinash Chandra Privacy Policy
Send us Fan MailThis week on Just MS News, we lead with encouraging—but still early remyelination research.Scientists have identified an experimental small molecule that promoted oligodendrocyte development and remyelination in preclinical models. We explain how this candidate differs from PTD802, the remyelination therapy we recently covered as it prepared to enter human testing.We also look at:• Fampridine becoming routinely available through NHS England for eligible adults with MS-related walking difficulties• Evidence examining whether treatment escalation after clinically silent MRI lesions may reduce future relapse risk• New research exploring how anti-CD20 therapies may affect protective immune cells originating in the gut• A large U.S. analysis identifying racial, geographic and age-related disparities in MS-associated mortality• Two brothers continuing their remarkable marathon journey using an adaptive racing wheelchairARTICLES AND SOURCES1. A Novel Small Molecule Remyelination Therapy for Multiple Sclerosis Source: npj Drug Discovery https://www.nature.com/articles/s44386-026-00060-72. Thousands With MS to Get Fampridine on the NHS to Help Them Walk More Freely Source: NHS England https://www.england.nhs.uk/2026/07/thousands-ms-life-changing-drug-nhs-help-walk-more-freely/Clinical commissioning policy:https://www.england.nhs.uk/publication/clinical-commissioning-policy-prolonged-released-pr-fampridine-as-a-treatment-of-adults-with-multiple-sclerosis-and-associated-walking-impairment/3. Treatment Escalation After Clinically Silent MRI Lesions in Relapsing-Remitting Multiple Sclerosis Source: Brain https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awag252/87413054. Anti-CD20 B-Cell Depletion Is Associated With Elevated Mucosal-Originating Circulating Immune Cells Source: Science Translational Medicine https://www.science.org/doi/10.1126/scitranslmed.aee15805. Racial and Ethnic Trends and Comorbidity Patterns in Multiple Sclerosis Mortality Source: Neurology Open Access https://www.neurology.org/doi/10.1212/WN9.00000000000001486. Man With MS Does Marathons With a Push From His Brother Source: Deseret News https://www.deseret.com/sports/2026/07/22/deseret-news-marathon-brian-danny-connolly-wheelchair-ms-people-with-disabilities/Just MS News provides accessible summaries of multiple sclerosis news and research. This episode is for informational purposes and should not replace guidance from your healthcare team.Visit Just Multiple Sclerosis:https://www.justmultiplesclerosis.comListen to the podcast:https://www.justmultiplesclerosis.com/podcast#MultipleSclerosis #MSNews #Remyelination #MSResearch #Fampridine #MultipleSclerosisResearchThe Just MS (Multiple Sclerosis) Show, w host Justin Loizos, is a podcast that connects, educates and tries to uplift others living with multiple sclerosis. It provides real-life stories, interviews, and information about DMTs (disease modification therapies) and updates on research developments.www.justmultiplesclerosis.com
Richie Brave is joined by Julie Adenuga to discuss grime music as well as Roxy Murray, who speaks about lived experiences of Multiple Sclerosis. @1Xtra on socialProduced by Unedited for BBC Radio 1Xtra.
Multiple Sclerosis (MS) is a neurodegenerative disease that slowly breaks down the lining around the body's nervous system which weakens the body's internal signals. The longer someone with MS has it, the worse their symptoms get. There is no current cure for Multiple Sclerosis and no definitively known cause for the disease. In today's episode of Health 411, Dr Jonathan Karp and student producer Dan Loges delve into discussion about Multiple Sclerosis; a personal topic for both as Dr. Karp's mother had it, and Dan's grandfather had it. They discuss the disease and share stories about their personal experiences with this illness. Tune in to this weeks episode of Health 411 to learn more about the autoimmune disease, Multiple Sclerosis.
All Home Care Matters and our host, Lance A. Slatton were honored to welcome Rebekah Dowhy & David Beeton as guests to the show. About Rebekah Dowhy: Rebekah is the President of the Caregiving Support Network, a ministry offering prayer, community, and practical support to family caregivers. Her most important role was being a primary caregiver to her Mom, Sherrie who had Multiple Sclerosis for 21 years. About David Beeton: David is the Vice President of Programs for the Caregiving Support Network. He is also serving as a Congregational Care Prayer Director at his church: Experience Community Church in Cannon County, Tennessee. He was a caregiver for his wife Sherrie, who had Multiple Sclerosis for 21 years. About Caregiving Support Network: The Caregiving Support Network ministry equips churches to reach caregivers in their community through prayer, community, and practical help. By working with the Caregiving Support Network, churches can show an unreached people group the love of Jesus.
"We have to stay on top of it. There isn't a golden year where MS suddenly decides to be kind to us." Growing older is something we all experience. But when you live with Multiple Sclerosis, aging often raises a different question: Which changes are simply part of getting older, and which are caused by MS? In this episode, we reflect on a recent MS Views and News webinar featuring Dr. Aaron Boster—MS and Aging—that challenged us to think differently about aging with MS. We discuss disease-modifying therapies, protecting our functional reserve, and the healthy habits that can help preserve the life and abilities we have today. We also share updates from our recent neurology visits and infusion treatments, discuss adapting to changes in healthcare, and reflect on why community support remains one of the best resources for navigating life with MS. In this episode, we explore: Why aging and Multiple Sclerosis are often intertwined and why it can be difficult to tell them apart. What Dr. Aaron Boster shared about disease-modifying therapies and why they continue to matter as we grow older. The importance of protecting your functional reserve through exercise, nutrition, sleep, hydration, and healthy lifestyle choices. Our recent infusion experiences, changing treatment routines, and adapting to new healthcare challenges. Why support groups, shared experiences, and practical tips from others living with MS can make all the difference. Keep the conversation going What habits or routines have helped you age well while living with MS? We'd love to hear your story and learn what's worked for you. Connect with us through our website or at acoupletakesonms@gmail.com. *** Thank you for listening to A Couple Takes on MS. We're grateful you're moving forward with us one step, one roll, and one story at a time. If you enjoyed this episode, please consider following the podcast, leaving a rating or review, and sharing it with someone who could use a little encouragement today.
If you've spent any time at all living with or caring for someone with multiple sclerosis, you know that medical textbooks and information-filled websites can give us facts, figures, and symptoms, but they rarely capture the sometimes messy, sometimes overwhelming, and sometimes darkly funny reality of what it actually feels like to get a diagnosis of MS and realize your life has suddenly shifted under your feet. Our guest, Liat Shalom, was diagnosed with MS in 2021, at the age of 30. Instead of letting that diagnosis define her, Liat picked up her pen and created Unravelled—a groundbreaking graphic memoir that refuses to sugar-coat the MS experience. For about five years, we've known that the Epstein-Barr virus (EBV) triggers MS. We'll explain what biologists just discovered about how EBV triggers MS, and what that could mean for future treatments. We're sharing evidence from an important study that shows a simple blood test is as accurate as MRI in determining whether someone is experiencing a relapse or a pseudo-relapse. We're sharing details of a study showing that virtual reality (VR) therapy is effective in treating MS-related brain fog. And if you're a woman between the ages of 45 and 60 and you're experiencing perimenopause, we'll share an easy way for you to participate in MS research without leaving home. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Unravalled, Liat Shalom's darkly humorous graphic novel about her MS journey :22 Scientists discover how the Epstein-Barr virus triggers MS 1:53 A simple blood test can determine whether someone is experiencing a relapse or a pseudo-relapse 4:08 It's time to support the National MS Society's $119.6 million active investment in MS research 6:58 Virtual reality therapy can improve MS-related brain fog 9:16 An opportunity to participate in MS research for women between 45-60 who are experiencing perimenopause 11:41 Liat Shalom discusses her journey to an MS diagnosis that led her to create Unravalled, a darkly humorous graphic memoir 13:11 Share this episode 30:32 Next week 30:52 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/464 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com Unravelled: The Story of an MS Warrior by Liat Shalom https://unraveledgraphicnovel.com STUDY: CD4+ T-Cells Reactive to Epstein-Barr Virus Late Lytic Antigens are Enriched in Individuals with Multiple Sclerosis https://www.science.org/doi/10.1126/scitranslmed.adz6566 STUDY: Utility of Multi-Analyte Protein Assay to Distinguish Multiple Sclerosis Clinical Relapse from Pseudoexacerbation https://link.springer.com/article/10.1007/s40120-026-00984-2 STUDY: Effectiveness of Immersive and Non-Immersive Virtual Reality Interventions on Cognitive Function in People with Multiple Sclerosis: A Systematic Review https://www.mdpi.com/2077-0383/15/12/4534 PARTICIPATE IN RESEARCH: Perimenopause and Multiple Sclerosis https://www.nationalmssociety.org/news-and-magazine/news/ms-study-alert-perimenopause-survey STUDY: Effectiveness of Immersive and Non-Immersive Virtual Reality Interventions on Cognitive Function in People with Multiple Sclerosis: A Systematic Review https://www.mdpi.com/2077-0383/15/12/4534 SUPPORT: National MS Society Research https://nationalmssociety.org/research JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 464 Guest: Liat Shalom Privacy Policy
Pentagon plans widespread testosterone screening for troops; New study claims arthroscopic surgery for age-related degenerative changes of knees is worthless; Widely touted “precision” proton therapy doesn't outperform conventional radiation treatment for prostate cancer; Comparing the effectiveness of gummies and liquids vs. tablet or capsule forms of supplements; Supplements to lower LDL; Lithium orotate for Alzheimer's prevention; Novel ultrasound treatment may target inflammation in osteoarthritis; Researchers explore antiviral treatments for multiple sclerosis.
Panelists: Josh Anderson, Belva Smith and Brian Norton ATFAQ205: Q1. Multiple Sclerosis and office work, Q2. Sensory tools for loud environments, Q3. Screen Mag and accessibility tools for the computer, Q4. TBI memory and organizational tools, Q5. Future of autonomous transportation
What do you do when the life you've spent everything building is suddenly taken away from you overnight? Stephanie Millward MBE was 16, a British record-breaking swimmer heading for the Sydney Olympics, when she went blind, lost the ability to walk and was diagnosed with multiple sclerosis. Doctors gave her 10 years to live. She's now 44. In this episode, Stephanie takes me through one of the most extraordinary stories of reinvention I've ever heard ... how she learned to hold a funeral for her old self, get back in the pool, and go on to compete at four Paralympic Games, winning gold medals that nobody ... including her ... ever thought she'd live long enough to win. We talk about silencing the voice that tells you you're not enough, why every single bad thing that has ever happened to you might just be the best thing that ever happened to you, and how to write the ending of your story before you've even begun to live it. If you've ever faced a moment where everything felt lost ... this one is for you. The Unlock Moment is hosted by Dr Gary Crotaz, PhD — master interviewer, executive coach and author. Downloaded in over 140 countries. Sign up to The Unlock Moment newsletter at https://tinyurl.com/ywhdaazp Find out more at https://garycrotaz.com and https://theunlockmoment.com Also discover his other podcasts, The Box of Keys and Unlock Your Leadership. Follow, subscribe and leave a review wherever you get your podcasts — and connect with Dr Gary on LinkedIn for more leadership insights. Part of The Unlock Moment podcast family.
Send us Fan MailThis week on Just MS News, we examine new research that may help clarify how Epstein–Barr virus fits into the immune process behind multiple sclerosis.We also look at evidence supporting earlier high-efficacy treatment for pediatric-onset MS, the DOT-MS trial on stopping treatment after years of stable disease, virtual-reality rehabilitation for cognitive symptoms, and a Colorado community story about mobility, rehabilitation and assistive technology.This episode covers:• A more specific EBV-reactive T-cell response identified in people with untreated MS• Earlier high-efficacy treatment and long-term disability outcomes in pediatric MS• What happened when people with stable MS stopped certain disease-modifying therapies• Virtual-reality rehabilitation for cognition and mood• A bride with MS who prepared for a supported 68-foot aisle walkArticles and ResearchCD4+ T Cells Reactive to Epstein–Barr Virus Late Lytic Antigens Are Enriched in Individuals With Multiple SclerosisSource: Science Translational MedicineAuthors: Kjetil Bjornevik and colleaguesRead the studyEarly High-Efficacy Therapy May Reduce Disability in Pediatric MSSource: Neurology AdvisorBased on research published in NeurologyRead the articleDiscontinuation of Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis—Clinical Trial of the YearSource: JAMA NeurologyAuthor: S. Andrew Josephson, MDRead the editorialDiscontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis: The DOT-MS Randomized Clinical TrialSource: JAMA NeurologyAuthors: Eline M. E. Coerver, Wing Hee Fung, Janet de Beukelaar and colleaguesRead the original trialEffects of Virtual Reality-Based Rehabilitation on Cognitive Function and Mood in Multiple Sclerosis: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsSource: Multiple Sclerosis and Related DisordersAuthors: Jiongliang Zhang, Minmin Wu, Jinting Li, Wenjing Song, Xiaoguang Lin and Luwen ZhuRead the study on PubMedColorado Bride With MS Surprises Wedding Guests by Walking Down the AisleSource: 9NEWS ColoradoRead the storyVisit Just Multiple Sclerosis for the complete weekly digest:https://justmultiplesclerosis.comSubscribe for calm, clear and accessible weekly MS news without the information overload.#MultipleSclerosis #MSNews #JustMSNews #MSResearch #EpsteinBarrVirus #PediatricMS #MSRehabilitationThe Just MS (Multiple Sclerosis) Show, w host Justin Loizos, is a podcast that connects, educates and tries to uplift others living with multiple sclerosis. It provides real-life stories, interviews, and information about DMTs (disease modification therapies) and updates on research developments.www.justmultiplesclerosis.com
Welcome to IDEA Collider with your host, Rick Ritacco. In this episode, we sit down with Jason Tardio, President and COO of Immunic, to discuss the rapidly evolving landscape of Multiple Sclerosis (MS) treatment. For 30 years, MS therapies have primarily focused on controlling inflammation and visible relapses. Jason argues it's time to look deeper and address the ongoing neurodegeneration driving long-term disability, known as Progression Independent of Relapse Activity (PIRA). We explore Immunic's investigational therapy, vidofludimus calcium, and its unique dual-mechanism approach: acting as a DHODH inhibitor for anti-inflammatory benefits while also activating the Nurr1 nuclear receptor to potentially provide direct neuroprotection. Jason shares insights from the EMPHASIS and CALIBER clinical trials, discusses why the industry needs safer immunomodulators rather than just broad immunosuppressants (especially as the MS population ages), and shares a fascinating biological link between MS remission during pregnancy and Nurr1 levels. Tune in to hear what the next 10 to 15 years hold for MS patients, including the ultimate goals of halting progression entirely and achieving remyelination. Episode Timestamps 00:00:00 - Introduction: Meet Jason Tardio, President and COO of Immunic. 00:02:01 - The Evolution of MS Treatment: Transitioning from purely anti-inflammatory approaches to addressing underlying neurodegeneration. 00:04:29 - What is PIRA?: Understanding Progression Independent of Relapse Activity and why patients still accumulate disability. 00:10:30 - The Dual-Mechanism Approach: How vidofludimus calcium combines DHODH inhibition with Nurr1 activation. 00:13:33 - The Power of Nurr1: Exploring the target's role in neuronal survival and the fascinating biological link to pregnancy in MS patients. 00:18:14 - Clinical Validation: Analyzing data from the EMPHASIS (relapsing MS) and CALIBER (progressive MS) trials. 00:27:42 - Standing Out in a Crowded Market: Why safety, tolerability, and avoiding broad immunosuppression matter, especially for aging MS patients facing immunosenescence. 00:36:08 - The Next 10 Years: Moving towards halting progression, potential remyelination, and the need to reclassify MS beyond relapsing and progressive labels. Don't forget to Like, Share, Subscribe, Rate, and Review! Keep up with Jason Tardio; LinkedIn: https://www.linkedin.com/in/jason-tardio/ Keep up with Rick Ritacco: LinkedIn: https://www.linkedin.com/in/rritacco/ Follow IDEA Pharma On; Website: https://www.ideapharma.com/ Listen to more fantastic podcast episodes: https://ideacollider.simplecast.com/
Where someone lives can profoundly influence their multiple sclerosis journey. While advances in diagnosis and treatment have transformed MS care in many parts of the world, millions of people still face significant barriers to diagnosis, specialist care and life-changing therapies. In this episode of the ECTRIMS Podcast, host Brett Drummond speaks with Dr. Fiifi Duodu and Prof. Alfredo Damasceno about the realities of managing MS patients in diverse healthcare settings and what can be done to improve equity worldwide. Together, they discuss:
Dr. Hoffman continues his conversation with Dr. David Chernoff, Chief Medical Officer of Setpoint Medical.
Dr. David Chernoff, Chief Medical Officer of Setpoint Medical, discusses electrically driven vagus nerve stimulation (VNS) as a “neuroimmune modulation” approach to autoimmune and inflammatory disease. Chernoff explains the vagus nerve's sensory role in monitoring organs and signaling the brainstem and spleen to regulate immune responses, and how precise stimulation can reduce pro-inflammatory cytokines without immunosuppression. Setpoint's miniaturized, wireless, MRI-compatible implant is placed in an outpatient 45-minute neck procedure and delivers one minute of daily stimulation titrated to an upper comfort level; long-term safety is supported by prior surgical experience and a 242-patient blinded RA study with two-year data, leading to FDA approval for rheumatoid arthritis. The discussion covers add-on use with medications, potential steroid tapering, reimbursement, and research in Crohn's disease, relapsing MS (vision and remyelination), and other conditions, including psoriatic arthritis, lupus, and neurodegenerative diseases.
Living with depression has been described as "like living under a wet, heavy blanket". It can stop someone from showing up at work, meeting up with friends, and even connecting with their family. One out of every two people living with MS will experience depression at some point in their MS journey. The METS for MS study is focused on a novel approach to treating major depressive disorder among people with MS -- one that doesn't require another infusion, injection, or pill. This week, Dr. Robert Motl, principal investigator for the METS for MS study, joins us to explain what the study is about and what his team is learning. And Kelly, who lives with progressive MS, joins us to share how her participation in the study became life-changing. We'll also tell you about the $500,000 donation to MS research that Fernando Mendoza and his family just made. We're sharing the details about the CAR-NKT cell therapy for MS that's being developed at UCLA. You'll learn about the novel nanoparticle therapy for MS that's being developed by a team at Syracuse University's BioInspired Institute. And we're sharing the surprising results of a study that measured the effectiveness of Rituximab versus Ocrevus. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: A study focusing on a novel approach to treating MS-related depression :22 Fernando Mendoza and his family donate $500,000 to MS research 1:18 UCLA research team receives a $7.49 million dollar grant to develop CAR-NKT therapy for MS 2:22 Syracuse University research team receives NIH grant to develop novel nanoparticle therapy for MS 6:22 Study results: Rituximab and Ocrevus were compared head-to-head and the results are surprising 9:43 Dr. Robert Motl explains the Mood and Exercise Training Study for Multiple Sclerosis, and Kelly explains how her participation in the study turned out to be life-changing 14:22 Share this episode 35:43 Next week 36:03 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/463 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com STUDY: Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis https://www.nejm.org/doi/10.1056/NEJMoa2600993 PARTICIPATE: Mood and Exercise Training Study for Multiple Sclerosis (METS for MS) Email: METSforMS@uic.edu Phone Ariel: (312) 355-1790 JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 463 Guest: Dr. Robert Motl, Kelly Privacy Policy
Dr. Bill Andrews is the Founder and CEO of Sierra Sciences; a company focused on finding ways to extend human lifespan and health span. Bill has been featured in Popular Science, The Today Show, The Doctor's TV Show, and numerous documentaries on the topic of life extension. Bill co-stars with Dr. Aubrey de Grey in the documentary “The Immortalists” that made it to the “Top-10-List” to receive an Oscar in 2014Bill is also an ultramarathon runner with over 100 ultramarathons under his belt. Bill believes that consistent and fun endurance exercise is one of the best ways to reduce inflammation and slow aging.Speaking at the Cell Surgical Conference 2024Bill's areas of research have included Dwarfism, Cancer, CardiovascularDisease, Inflammation, Osteoporosis, Anemia, Multiple Sclerosis,Aging, and many others. Before founding Sierra Sciences Bill was aMedical Researcher at Armos Corporation, Codon Corporation, BerlexBiosciences, Geron Corporation, and EOS Biotech. Bill played key rolesin the discoveries and inventions of:Human Growth Hormone (hGH), Prorennin (Prochymosin), Tissue Plasminogen Activator(tPA), Osteo-Inductive Factor (OIF), Thrombomodulin, Erythropoietin (EPO), Beta-Seron, HTSite Specific Mutagenesis, Various Cancer Treatments (Rytelo, Telomelysin, GV1001, UV1,mutant hTR, and others), Telomerase, TRAPeze, TA-65, hTERT mRNA RT-PCR HTS,Telomerase Gene Therapy, C0314818 (TAM818), TeloSMRT, Isagenesis (Product B), Premere, Telo-Vital, Rytelo, and many more.In 1997 Bill was awarded 2nd Place as National Inventor of the Year for his cancer research. In the early-to-mid 1990s, while at Geron Corporation, Bill led the research to discover both the RNA and protein components of human telomerase, the enzyme responsible forpreventing telomeres from shortening in our reproductive cells. He has determined that the only real definite “hard-stop” to lifespan and health span, that is true for all humans, as well as non-human primates, cats, dogs, horses, sheep, pig, and deer, is “Telomere Shortening”. No matter what else we do to treat aging, aging will neverbe cured and/or reversed unless we also solve the telomere shortening problem.Presently, the primary focus of Sierra Sciences is to find ways toproduce telomerase and lengthen telomeres in all cells of the humanbody, not just our reproductive cells, and eliminate this key hard-stop tosuper-longevity. But Bill is aware that the war against aging is not goingto be won with just one battle.Contact Dr. Bill Andrews:website: https://sierrasci.com/https://www.facebook.com/telomere.bill.andrewshttps://www.facebook.com/profile.php?id=61551532301673linkedin.com/in/billandrewsphdhttps://www.youtube.com/@billandrewsphdhttps://www.youtube.com/@sierrasciences1625https://www.instagram.com/yonderssi/Dr. Kimberley LinertSpeaker, Author, Broadcaster, Mentor, Trainer, Behavioral OptometristEvent Planners- I am available to speak at your event. Here is my media kit: https://brucemerrinscelebrityspeakers.com/portfolio/dr-kimberley-linert/To book Dr. Linert on your podcast, television show, conference, corporate training or as an expert guest please email her at incrediblelifepodcast@gmail.com or Contact Bruce Merrin at Bruce Merrin's Celebrity Speakers at merrinpr@gmail.com702.256.9199Host of the Podcast Series: Incredible Life Creator PodcastAvailable on...Apple: https://podcasts.apple.com/us/podcast/incredible-life-creator-with-dr-kimberley-linert/id1472641267Spotify: https://open.spotify.com/show/6DZE3EoHfhgcmSkxY1CvKf?si=ebe71549e7474663 and on 9 other podcast platformsAuthor of Book: "Visualizing Happiness in Every Area of Your Life"Get on Amazon: https://amzn.to/4cmTOMwWebsite: https://linktr.ee/DrKimberleyLinertThe Great Discovery eLearning platform: https://thegreatdiscovery.com/kimberleyl
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In this Mind Moments episode, Daniel Ontaneda, MD, PhD, professor of neurology at the Cleveland Clinic Mellen Center for Multiple Sclerosis, discusses a recently published study in Neurology evaluating the application of the 2024 McDonald Criteria in individuals with nonspecific neurologic symptoms or incidental MRI findings. Using data from the CAHPS-MS study, Ontaneda explains how the revised diagnostic criteria perform in these previously understudied patient populations and what the findings may mean for earlier identification of multiple sclerosis. The conversation explores the rationale behind expanding the 2024 McDonald Criteria, the role of central vein sign and cerebrospinal fluid oligoclonal bands in improving diagnostic confidence, and how clinicians should approach patients who fall into a diagnostic gray zone. Ontaneda also discusses the practical application of the updated criteria, the importance of longitudinal follow-up, and how emerging biomarkers may continue to refine MS diagnosis in the years ahead. Looking for more Multiple sclerosis & demyelinating disorders discussion? Check out the NeurologyLive® Multiple sclerosis & demyelinating disorders clinical focus page.Episode Breakdown: 1:15 – Why the 2024 McDonald Criteria expanded diagnostic eligibility 4:30 – Applying the criteria in nonspecific symptom presentations 6:20 – Clinical relevance of symptom patterns and MRI findings 8:40 – Using biomarkers to improve diagnostic confidence 11:25 – Neurology News Minute 13:55– Interpreting dissemination in time with updated criteria 15:45 – Future validation of emerging MS diagnostic biomarkers The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: FDA Advisory Committee Schedules Meeting to Review Deramiocel's BLA in Duchenne Muscular Dystrophy FDA Clears PoNS Device for Stroke Rehabilitation, Expanding Neurostimulation Beyond MS Indication FDA Accepts Sarepta's sNDAs for Casimersen and Golodirsen for Duchenne Muscular Dystrophy Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
Pointing to Edward's first symptom of Relapse–Remitting MS is tricky. From anxiety in his 20s, to poor sleep and numb hands, to back pain and difficulty walking, the road to diagnosis has been rocky. When he finally received confirmation—in the form of a terrifying MRI showing countless lesions on his brain and spine—Edward was a new father in his early 30s. Coming to terms with a lifelong condition that presents differently for everyone was a process that has slowly shifted his outlook on both his past and his future. In this episode, we speak with Edward about what his journey through symptoms and diagnosis looked like, and reflect on how facing down a debilitating illness can change your outlook on life if you let it. A musician from a young age, today Edward is exploring live performance with his solo project, Green Plastic Whistle, and facing an aversion to fame that derailed some previous opportunities. As he puts it, being told you have an unpredictable disease, that has the potential to impact anything from bladder function to your ability to see, really puts fear into perspective. With cautious optimism and a balanced take on the pros and cons of the medical system, Edward and Jesse delve into how you envision your future when you don't know what your health will hold. They explore the promising remyelination medications that have the MS community abuzz and what it's like to start a family in the midst of disease progression. Edward's experience with Multiple Sclerosis has given him a new perspective on how we prioritize our lives and what's possible when you begin to face the future without fear. Learn more about Edward's solo project, Green Plastic Whistle: https://www.instagram.com/greenplasticwhistle/ Listen to Green Plastic Whistle on Spotify: https://open.spotify.com/user/0b6gv1y0qrwlp4bp3ztmusnsa?si=d557f3eb1a0947c2 https://www.youtube.com/watch?v=hV_reArTc7g Watch the episode on YouTube or Spotify, listen here on our website or on your favorite podcast platform. PODCAST LINKSWEBSITE: https://majorpainpodcast.comEMAIL: majorpainpodcast@gmail.comSUBSCRIBE: https://majorpainpodcast.com/subscribeSPOTIFY: https://open.spotify.com/show/5NDoD07WJmICdfdRKq0TyNAPPLE PODCASTS: https://podcasts.apple.com/us/podcast/major-pain/id1562947550?mt=2&ls=1 SOCIAL MEDIAINSTAGRAM: https://www.instagram.com/majorpainpodcastTIKTOK: https://www.tiktok.com/@majorpainpodcastYOUTUBE: https://www.youtube.com/@MajorPainPodcastFACEBOOK: https://www.facebook.com/majorpainpodcast AFFILIATE LINKSRARE PATIENT VOICE: https://rarepatientvoice.com/MajorPainPodcastAMAZON SHOP: https://www.amazon.com/shop/majorpainpodcastNEURAHEALTH: https://www.neurahealth.co/majorpain
Today, I am talking to Liz Bentley, psychotherapist, writer, comedian, poet and performer. Liz has recently released her brand NEW memoir; The Suicidal Therapist, Confessions of a Wounded Healer on Survivors Voices Press. This is her heartfelt and authentic story, diving into some of the aspects of mental health that we often don't talk about. Liz sought therapy in her early twenties, whilst dealing with problems with bulimia, intimate relationships, drugs, grief and being diagnosed with Multiple Sclerosis. She talks candidly about these subjects in her book. Liz has worked extensively for over thirty-four years as a psychotherapist, supervisor and facilitator in the NHS, Goldsmiths College, Lewisham College (in London) and private practice. Liz has performed with her comedy poetry at The Poetry Cafe, London Literature Festival, Leicester Square Theatre, Edinburgh Festival, The Ivy House and many other festivals and venues. In the episode today, Liz is going to dive into her life journey, taking us behind the scenes of her imperfect, complicated, persevering and vibrant path. It's an honest and frank conversation to inspire hope and encouragement to anyone who is struggling today. You can order a copy of Liz's book at Survivor's Press https://survivorsvoices.org/survivors-voices-press/ and also from Amazon https://www.amazon.co.uk/Suicidal-Therapist-Confessions-Wounded-Healer-ebook/dp/B0GC9LS63N Liz's website: https://lizbentley.co.uk/
On this episode of the podcast, we are joined by BJJ Black Belt and UFC veteran Professor Alberto Crane. Professor Crane discusses his start in BJJ in 1994 and eventually transitioning to fighting in early MMA events starting at King of the Cage, old school training in the 1990's, the evolution of BJJ in MMA, the evolution of BJJ in sport jiu-jitsu, how to make sport BJJ more exciting, overcoming his early struggles in BJJ competition, how to transfer success in the gym to success in tournaments, training for longevity, how getting diagnosed with Multiple Sclerosis has impacted his life, and Professor Crane's book titled "All In." You can check out his book here: All In: Lessons On and Off The Mat Thanks to the podcast sponsors: Datsusara, head over to https://www.dsgear.com/ and use the code Chewjitsu10 to get 10% off of the highest quality hemp gear for BJJ. Check out "Athlethc" at https://athlethc.com/ and use the code Chewjitsu10 to get 10% off of your order of hemp-derived THC performance mints. Charlotte's Web CBD. Head over to https://bit.ly/chewjitsu30 and use the promo code Chewjitsu30 to get 30% off of your total purchase. Epic Roll BJJ. Check out https://epicrollbjj.com/ and use the promo code Chewjitsu20 to get 20% off of your total purchase. Check out podcast exclusives including conversations with guests, Q&A sessions, and tons more at https://patreon.com/thechewjitsupodcast
PeerView Family Medicine & General Practice CME/CNE/CPE Video Podcast
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
PeerView Neuroscience & Psychiatry CME/CNE/CPE Audio Podcast
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
PeerView Neuroscience & Psychiatry CME/CNE/CPE Video Podcast
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
PeerView Family Medicine & General Practice CME/CNE/CPE Audio Podcast
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/PFX865. CME/MOC/AAPA/IPCE credit will be available until June 27, 2027.New Pathways, New Possibilities in Multiple Sclerosis: BTK Inhibition and the Future of Patient Care In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Genentech, a member of the Roche Group.Disclosure information is available at the beginning of the video presentation.
Jamie Lynn Sigler grew up in front of the world as Meadow Soprano, one of television's most iconic daughters. But while she was coming of age on screen, she was privately carrying a secret that almost nobody knew: at age 20, she was diagnosed with multiple sclerosis. For 14 years, she hid her diagnosis from Hollywood, her coworkers, and her friends out of fear and shame. Now, Jamie sits down with Hoda Kotb to pull back the curtain on a life no longer built on perfection, but on radical honesty. She opens up about her deeply moving memoir, And So It Is, which begins with a terrifying medical crisis involving her young son, Beau. Jamie shares how she broke through the paralyzing loop of childhood trauma through EMDR therapy, what it was like to finally confide in her late co star James Gandolfini, and how she found peace by letting go of the need to pretend she was always fine. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
July is Healthy Vision Month, and the National Eye Institute—part of the National Institutes of Health—reminds us to take care of our eyes, by eating a healthy diet and exercising, and also by understanding the connection between our vision and other diseases. Multiple sclerosis, or MS, is one of those diseases. Dr. Barbara Giesser, who specializes in treating patients with MS at Pacific Neuroscience Institute, says that often times, a sudden loss of vision is the first indication that a person might have MS. Dr. Howard Krauss, one of the founders of Pacific Neuroscience Institute and a neuro ophthalmologist, notes that 40 percent of the brain's activity is related to vision—so it makes sense that a disease of the brain like MS would have such a big impact on vision. We're revisiting this conversation between these two doctors who have partnered in ways that can detect MS very early in the process, and to monitor the optic nerve to see how well MS treatments are working. Let's listen in!
Sarah Thomas is a force of nature. As Strategic Partnerships and Programs Manager at The Venture Center in Little Rock, she helps entrepreneurs at every stage find their footing — from building a first website to navigating complex government contracts. But that's just one of her many hats. She's also a published author, a yoga instructor, president of Women in Tech Central Arkansas, and a woman living with Multiple Sclerosis who refuses to let any of it slow her down.In this episode, we cover:What The Venture Center is and how it supports entrepreneurs in Arkansas Their 12-week program for veteran-owned businesses, connecting vets with SBA resources, attorneys, marketing pros, and moreArkansas's emerging role as a lithium hub — what's happening in South Arkansas, who's involved (think Standard Lithium, Exxon, Tetra, and others), and what it could mean for jobs, schools, and communities statewideSarah's book, Chair Yoga for Multiple Sclerosis and Chronic Pain, available now at Barnes & Noble, Amazon, and WalmartHow her yoga mindset shows up in her work with entrepreneurs: breathe, get present, focus on what you can do todayWhat it's like being the only woman — and often the only woman of color and person with a disability — in high-level rooms, and how she handles itHer advice for women and girls interested in STEM: always be a student, find mentors, and then turn around and teachResources mentioned:The Venture Center: venturecenter.coWomen in Tech Central Arkansas (sponsored by Google and Walmart)National MS SocietySarah's mantra: Don't waste your breath on negativity. Use it for positivity. Be your own hero.
"Sometimes the best medical news isn't dramatic. Sometimes it's hearing one simple word: Stable." Continuing our previous conversation about Multiple Sclerosis progression and reclassification, we're back with the update we'd been hoping to share. After meeting with our neurologist, reviewing MRI results, and establishing care with a new primary care provider, we're reflecting on what stability really means after living with Multiple Sclerosis for decades and why "stable" can be one of the most encouraging words you'll ever hear. We also talk about rebuilding strength after setbacks, why physical therapy still matters, and the importance of finding healthcare providers who truly listen. In this episode, we discuss: The relief of hearing "no new lesions" after an MRI. Why rebuilding strength after surgery and deconditioning takes patience. How living with MS doesn't mean ignoring the rest of your health. Why finding healthcare providers who listen and partner with you makes all the difference. How physical therapy, exercise, and adaptive equipment continue to play important roles in our lives. Why we're choosing to move forward rather than living in fear as we continue aging with Multiple Sclerosis. We also explore why building strong relationships with your neurologist and primary care provider can make a tremendous difference throughout your MS journey. We'd love to hear from you What makes a great neurologist or healthcare provider in your experience? Have you ever changed doctors because you weren't being heard? Or have you found a physician who has made all the difference in your MS journey? Share your thoughts in the comments or connect with us through our website or Email Thank you for listening to A Couple Takes on MS. We're grateful you're moving forward with us one step, one roll, and one story at a time. *** Remember to rate, review, and subscribe to A Couple Takes on MS Podcast for two insightful perspectives on this one multifaceted disease.
Lina Nielsen is an Olympic sprinter and hurdler who has overcome incredible challenges to reach the top of her sport.Growing up in East London, Lina got the chance to be a kit carrier at the London 2012 Olympic Games. Seeing the world's greatest athletes up close made her dream of competing in the Olympics one day too. But when she was just 17, Lina was diagnosed with Multiple Sclerosis after the right side of her body became paralysed. She thought her Olympic dream was over. It wasn't. In our conversation, Lina shares how she defied the odds to achieve her dreams, what it took to get there and what she's aiming for next. In this episode, Lina shares:Her incredible journey to Olympic bronze Growing up without her dad and its impact on her relationshipsBeing diagnosed with MS at 17 The misconceptions about MS she's determined to break downLearning to accept her diagnosis without letting it define herLina's story is a powerful reminder that the labels we're given don't define what's possible.Lina Nielsen is Great Company.Lina will be competing in the Birmingham 2026 European Athletics Championships in August. You can buy tickets HERE! https://tickets.birmingham26.com/If you enjoyed the show, you can also follow us: Instagram- @greatcompanypodcastTikTok - @greatcompanypodcast Jamie - @jamielaingAnd if you've got thoughts, questions and comments, you can email us at: greatcompany@jampotproductions.co.ukTHE CREDITSProducers: Helen Burke & Dan KingAssistant Producer: Issy Weeks-HankinsVideo: Josh BennettSenior Social Media Manager: Laura CoughlanAudio: Rafi Amsili GeovannettiExecutive Producer: Ewan Newbigging-ListerGreat Company is an original podcast from JamPot. Hosted on Acast. See acast.com/privacy for more information.
Our guest this week is Jamie Bark, of New Ricchmond, WI, a fire fighter, former owner of Value Auto Glass, a widower and father of two daughters, including one with Spinal Muscular Atrophy.Jamie and his wife, Jackie, were married for 30 years, before she very sadly passed away in January of 2025 after a long battle with Multiple Sclerosis. He is also the proud father of two daughters: Maddie (21) and Gabby (17) who has a type of Muscular Dystrophy known as Spinal Muscular Atrophy (SMA) level 2. Jamie reflects on his life as a firefighter and private business owner, the struggles of raising a child with SMA, losing his wife to a debilitating disease and becoming a sole parent as well as the role Cure SMA and MDA have played on behalf of his family. Jamie's story speaks volumes about his commitment to family, perseverence and reslience all on this episode of the sFN Dad To Dad Podcast. Show Notes - Phone – (715) 222-0369Email – valueglassco@gmail.comLinkedIn - https://www.linkedin.com/in/jamie-bark-74631022/MDA – https://www.mda.org/Cure SMA - https://www.curesma.org/SFN Audiobook 'On Losing A Child' - https://tinyurl.com/46jueh3s Special thanks to all those who supported the SFN U.S. Tour, a month-long, 50-state, 60+ stop tour that took place from May 21 to June 21, 2026: to strengthen and grow the Special Fathers Network and distribute 1,000 complimentary copies of our new book: Dads Raising Children With Special Needs & Disabilities: A Guide For 21st Century Dads. Special Fathers Network –SFN is a dad to dad mentoring program for fathers raising children with special needs. Many of the 800+ SFN Mentor Fathers, who are raising kids with special needs, have said: “I wish there was something like this when we first received our child's diagnosis. I felt so isolated. There was no one within my family, at work, at church or within my friend group who understood or could relate to what I was going through.”SFN Mentor Fathers share their experiences with younger dads closer to the beginning of their journey raising a child with the same or similar special needs. The SFN Mentor Fathers do NOT offer legal or medical advice, that is what lawyers and doctors do. They simply share their experiences and how they have made the most of challenging situations.Check out the 21CD YouTube Channel with dozens of videos on topics relevant to dads raising children with special needs - https://www.youtube.com/channel/UCzDFCvQimWNEb158ll6Q4cA/videosPlease support the SFN. Click here to donate: https://21stcenturydads.org/donate/Special Fathers Network: https://21stcenturydads.org/
As a country, we're living longer than ever before. The average life expectancy in the United States is now 79 years old, according to the Centers for Disease Control. But how are we doing when we get to our golden years? In Ohio, the answer is not necessarily the best, according to the latest America's Health Rankings Senior Report. This study from The United Health Foundation ranked Ohio 36th in the country in overall health for seniors. Some major concerns include suicide rates, drug related deaths, poverty and food insecurity concerns and levels of physical activity. When you add in concerns about mental function and emotional wellbeing, there's a lot to think about as we age. On Tuesday's edition of the "Sound of Ideas," we're looking at what we can do in our younger years to try to maintain our mental, emotional and physical health for as long as our bodies will let us. Guests: - Gary Grosel, M.D., Chief Medical Officer, UnitedHealthcare of Ohio - Lester Carney, age 92, Olympic athlete who won a silver medal in the 200-meter dash at the 1960 Summer Olympics in Rome, Italy - Robert Bermel, M.D., Staff Neurologist, Neurological Institute's Mellen Center for Multiple Sclerosis at Cleveland Clinic - Roopa Anmolsingh, M.D., Lead Geriatrician for Community Programs, Cleveland Clinic
Next week, Matt Knaggs and Colin Goodman will attempt to set a Guinness World Record for running the 350-mile length of Ireland with MS. This week, you'll meet Matt and Colin and learn why this undertaking is so important to each of them. We're also sharing survey results that point to gaps in how we approach MS care from the day of diagnosis. We'll tell you what it really means when you read that the prevalence of MS is increasing. It isn't bad news at all! We'll provide you with all the details you need to register for ECTRIMS Patient Community Day. And, if you can spare 20 minutes, we'll tell you how you can participate in an MS research study from the comfort of your own home. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: We're hitting the open road in Ireland with Matt Knaggs and Colin Goodman :22 Survey points to gaps in how we approach MS care from day one 2:48 What does the increase in MS prevalence really mean? 8:48 Register for ECTRIMS 2026 Patient Community Day 12:33 An opportunity for you to participate in MS research without leaving home 14:10 Matt Knaggs and Colin Goodman talk about their attempt to set a Guinness World Record for running the length of Ireland with MS 15:56 Share this episode 32:13 Next week 32:33 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/460 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com STUDY: Understanding the Unmet Needs of People with MS at Diagnosis and Throughout Their Care Journey: Insights from a Survey-Based Study https://link.springer.com/article/10.1007/s40120-026-00942-y STUDY: Drivers of Prevalence in Major Motor Neurodegenerative Diseases: Temporal Trends in Sweden and France (2003-2022) https://www.neurology.org/doi/10.1212/WNL.0000000000218072 REGISTER: ECTRIMS 2026 Patient Community Day https://www.ectrimspatientcommunity.eu PARTICPATE IN RESEARCH: Survey: Automatic and Reflective Determinants, Fatigue, and Physical Activity for People with Multiple Sclerosis https://purdue.ca1.qualtrics.com/jfe/form/SV_douenJftXAcGxVk JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 460 Guest: Matt Knaggs, Colin Goodman Privacy Policy
Selena Freisens, Head of Global Medical Affairs at Merz Therapeutics, is focused on increasing access to tools to support neurological health. They have developed a digital app iFlexo, which is designed to provide at-home physiotherapy for stroke survivors. The app has been tested in Nigeria and Sierra Leone in partnership with the World Stroke Organization and is designed to operate offline as well, to serve users in rural areas with limited internet connectivity. Selena explains, "Our company is family-owned and in its fifth generation, so we have a rather long-term legacy, and the newer part is Merz Therapeutics, and our focus in Merz Therapeutics is on neuroscience. So we practically cover the number of movement disorders such as Spasms, Dystonias. We also have a focus on Parkinson's and Multiple Sclerosis." "We continuously work on building this awareness and knowledge. One example is Parkinson's disease. And when I started working with Parkinson's disease, most of the patients would have off episodes, which are exacerbations of their symptoms, but many of these off episodes are underdiagnosed, and they're not really treated optimally. So it's really a lot of attention is needed to educate not only HCPs and, of course, some other stakeholders, but particularly patients." "So the time also matters for stroke survivors. So it's very important that they start as soon as possible all the therapies, but also the physiotherapy at the same time. What this digital tool does is give two options. One is education on the one side, and on the other hand, a guided exercise that will enable people and stroke survivors to exercise at home. And with that, obviously, the personalized goals have been worked out together with the experts and HCPs so that they can achieve those goals faster, while working from home." #MerzTherapeutics #StrokeRehab #DigitalHealth #NeuroRehab #AccessToHealth #WorldStrokeOrganization #Physiotherapy #HealthEquity #TeleRehab #HCPs #Africafirst #AccesstoHealth #EquitableAccess #PostStrokeRehabilitation #PatientDrivenInnovation Merztherapeutics.com Download the transcript here
Selena Freisens, Head of Global Medical Affairs at Merz Therapeutics, is focused on increasing access to tools to support neurological health. They have developed a digital app iFlexo, which is designed to provide at-home physiotherapy for stroke survivors. The app has been tested in Nigeria and Sierra Leone in partnership with the World Stroke Organization and is designed to operate offline as well, to serve users in rural areas with limited internet connectivity. Selena explains, "Our company is family-owned and in its fifth generation, so we have a rather long-term legacy, and the newer part is Merz Therapeutics, and our focus in Merz Therapeutics is on neuroscience. So we practically cover the number of movement disorders such as Spasms, Dystonias. We also have a focus on Parkinson's and Multiple Sclerosis." "We continuously work on building this awareness and knowledge. One example is Parkinson's disease. And when I started working with Parkinson's disease, most of the patients would have off episodes, which are exacerbations of their symptoms, but many of these off episodes are underdiagnosed, and they're not really treated optimally. So it's really a lot of attention is needed to educate not only HCPs and, of course, some other stakeholders, but particularly patients." "So the time also matters for stroke survivors. So it's very important that they start as soon as possible all the therapies, but also the physiotherapy at the same time. What this digital tool does is give two options. One is education on the one side, and on the other hand, a guided exercise that will enable people and stroke survivors to exercise at home. And with that, obviously, the personalized goals have been worked out together with the experts and HCPs so that they can achieve those goals faster, while working from home." #MerzTherapeutics #StrokeRehab #DigitalHealth #NeuroRehab #AccessToHealth #WorldStrokeOrganization #Physiotherapy #HealthEquity #TeleRehab #HCPs #Africafirst #AccesstoHealth #EquitableAccess #PostStrokeRehabilitation #PatientDrivenInnovation Merztherapeutics.com Listen to the podcast here
"We aren't looking for answers yet. We're learning how to sit with the questions." As we prepare for an upcoming appointment with our neurologist, a simple question from Jennifer sparked a conversation neither of us expected to have. What if Dan's MS has progressed? To be clear, nothing has changed. We haven't received any new diagnosis, and Dan has not been reclassified from relapsing-remitting MS to secondary progressive MS. But after nearly three decades of living with Multiple Sclerosis and noticeable changes in his gait and energy levels, it felt like an important conversation to have. In this episode, we talk openly about our fears, questions, and uncertainties that can come with long-term MS. We discuss: What prompted us to start talking about disease progression before our upcoming neurology appointment How physical therapy has revealed both strengths and challenges in Dan's mobility and endurance Jennifer's experience transitioning from relapsing-remitting MS to secondary progressive MS years ago The realities of caregiving, aging, and adapting to changes in ability over time Why community, conversation, and preparation matter when facing difficult questions about the future More than anything, this episode is about facing possibilities without letting them define us. Regardless of what happens at our next neurology appointment, we are still the same people we were before we walked into the office. We hope you'll join us for this conversation, especially if you've ever wondered what the future might hold for your MS or how to navigate the uncertainty that comes with living with a chronic illness. *** Remember to rate, review, and subscribe to A Couple Takes on MS Podcast for two insightful perspectives on this one multifaceted disease.
In this deeply healing episode of Mirror Talk: Soulful Conversations, Christine Ruch joins us to explore nervous system healing, body wisdom, chronic illness, emotional capacity, and the sacred journey of healing from within.Christine is a Holistic Transformation Guide who helps people reconnect with their body's innate intelligence and healing potential. After walking through her own 20-year healing journey with Multiple Sclerosis and chronic health challenges, she now supports others in restoring their nervous system, rebuilding self-trust, releasing stored trauma, and returning to deeper alignment in body, mind, soul, and spirit.This conversation is an invitation to stop fighting the body and begin listening to it. Christine reminds us that symptoms are not always enemies to silence. Sometimes, they are messengers guiding us toward truth, surrender, compassion, and inner restoration.In This Episode, We ExploreNervous system healing as a gateway to transformationHow chronic illness can become an invitation to listen more deeplyBuilding emotional capacity and resilienceWhy many people feel disconnected from their bodiesThe role of trauma, unresolved emotions, and stored pain in healingHow to release control and trust the body's intelligenceWhat aligned embodiment looks like in everyday lifeThe meaning of holding space without fixing or forcingHow personal healing contributes to collective healingA loving first step for anyone feeling tired, stuck, or discouragedKey TakeawaysYour body is not your enemy. It may be carrying messages that need compassion, attention, and deeper listening.Nervous system restoration can help create the inner safety needed for emotional release, trauma healing, and spiritual alignment.Healing is not only about symptom management. It is also about rebuilding trust with yourself and learning how to live from a calmer, more connected place.Emotions are not who you are. They can be witnessed, felt, and released without becoming your identity.The illusion of control can keep us disconnected from the deeper intelligence of the body. Surrender can open the door to liberation.Memorable Quotes“I love life.”“Your emotions are not who you are.”“She'd be really proud of me.”Chapters00:00 The Journey of Healing and Transformation07:44 Listening to the Body's Wisdom17:29 Trust, Surrender, and Self-Love22:01 The Illusion of Control25:10 Building Emotional Capacity27:53 Witnessing Emotions Without Judgment32:42 The Journey to a Calmer Nervous System36:29 Healing from Within38:03 Holding Space for Others42:51 Embarking on the Healing JourneyConnect with Christine RuchWebsite: https://www.christineruch.com/Substack: The Fresh LifeListen to This Episode If You Are AskingHow do I begin healing from within?Why does my body feel overwhelmed or unsafe?How can I rebuild trust with my body after illness?What does nervous system healing really mean?How can emotional capacity support trauma release and inner peace?Gentle NoteThis episode is shared for educational and inspirational purposes only. It is not medical advice. Please consult a qualified healthcare professional for medical diagnosis, treatment, or personal health decisions.If this conversation encouraged you, please share it with someone who is walking through a healing journey. Subscribe to Mirror Talk: Soulful Conversations, leave a review, and continue the journey with us as we explore healing, purpose, self-awareness, and transformation.Watch on YouTube: https://youtu.be/917B8Ex-SOc Try Aletheia today: https://aletheia.mirrortalkpodcast.com Ask what is on your heart. Mirror Talk will reflect back what may help you see more clearly. Try it here: https://mirrortalkpodcast.com/ask-mirror-talk/Could you support us by becoming a Patreon? Please consider subscribing to one or more of our offerings at http://patreon.com/MirrorTalk
This week, our coverage of the Consortium of MS Centers annual meeting continues with my guest, Dr. Stephen Krieger. In a wide-ranging conversation, Dr. Krieger offers a very encouraging clinical trial update, shares his thoughts on what treating someone living with advanced MS ought to look like, and points out potential obstacles to implementing the updated criteria for diagnosing MS. Dr. Krieger is a Professor of Neurology at the Icahn School of Medicine at Mount Sinai in New York, and a Multiple Sclerosis Specialist at the Corinne Coldsmith Dickinson Center for MS. We're also sharing results of a study that revealed some surprising connections between caffeine, alcohol, opioids, and MS symptoms. And if you're living with MS and you're the parent of a young child, we'll tell you about a book that belongs on your bookshelf. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: We're at the CMSC annual meeting with Dr. Stephen Krieger :22 Study reveals the connection between caffeine, alcohol, and opioids and your MS symptoms 1:12 My Superhero with Wheels is the book you need if you're living with MS and have young children 5:15 Dr. Stephen Krieger discusses exciting clinical trial results, treating people with advanced MS, and potential challenges in implementing the updated criteria for diagnosing MS 8:39 Share this episode 30:22 Next week 30:41 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/458 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes at www.RealTalkMS.com STUDY: Daily Temporal Associations Between Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People with Multiple Sclerosis https://archives-pmr.org/article/S0003-9993(26)00035-3/fulltext BOOK: My Superhero with Wheels https://amazon.com/My-Superhero-wheels-True-Story/dp/B0GWVGSWX5/ref=sr_1_1 JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on X, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 458 Guest: Dr. Stephen Krieger Privacy Policy
Montel Williams grew up in one of Baltimore's toughest neighborhoods. At 7 years old, a teacher tried to define him by the color of his skin. That day, he made a decision that shaped everything no one else would ever own the definition of who he was.That mindset took him from the streets of Baltimore to the Naval Academy, from military intelligence to 17 years of daytime television with 100% creative control and through a diagnosis of Multiple Sclerosis he's been fighting for over 20 years.In this conversation, Moshe Popack sits down with Montel Williams to talk about discipline, faith, and what it really means to build a life on your own terms.Timestamp: 0:00 Growing Up in One of Baltimore's Toughest Neighborhoods3:30 The Belief He's Carried Since Childhood5:00 First African American to Graduate the Naval Academy Prep School7:00 How a Speaking Tour of 1.5M Kids Built a TV Empire9:00 100% Creative Control Why the Show Lasted 17 Years10:00 The Real Reason Most People Never Know Who They Are11:30 What Fatherhood Actually Teaches You About Letting Go13:30 The MS Diagnosis and the Fight That Followed15:00 How to Reduce Inflammation and Take Control of Chronic Illness16:00 The Only Way Out Is Through His New Project25:30 The Teacher Who Tried to Define Him in Second Grade27:00 What Montel Williams Wishes for the World