Medical condition in which excess body fat harms health
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Credits: 0.75 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-500 Overview: To celebrate our 500th episode, each member of our team revisits a popular topic from the podcast's earlier installments—GLP-1s, cervical and breast cancer screening, diet and exercise, contraception, hypertension, and lipid management—to trace how the evidence and guidelines have changed since it was first covered. Whether you're catching up or reinforcing what you know, this milestone episode helps you bring the latest evidence into everyday patient care. Guest: Robert Baldor, MD, Alan Ehrlich, MD, Susan Feeney, DNP, FNP-BC; FAANP, Jillian Joseph, PA, Mariyan L. Montaque, DNP, FNP-BC, Jill Terrien PhD, ANP-BC, FAAN Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com Episode resource links: Zhou H et al. Evaluation and Comparison of the PREVENT and Pooled Cohort Equations for 10‐Year Atherosclerotic Cardiovascular Risk Prediction. Journal of the American Heart Association Volume 14, Number 4 Goff DC et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation. 2014;129:S49–S73. Circulation. 2018 Jul 24;138(4):345-355. eClinicalMedicine 2025: 103741. Curry, J. (2018). Screening for cervical cancer: US Preventive Services Task Force Recommendation Statement. JAMA.320(7):674-686. doi:10.1001/jama.2018.10897 https://www.ncbi.nlm.nih.gov/pubmed/30140884 Perkins RB, Wolf AMD, Church TR, et al. Self-collected vaginal specimens for human papillomavirus testing and guidance on screening exit: An update to the American Cancer Society cervical cancer screening guideline. CA Cancer J Clin. 2026;e70041. doi:10.3322/caac.70041 Screening for Cervical Cancer (2026). Obstetrics & Gynecology, 148(1), e63-e67. https://doi.org/10.1097/AOG.0000000000006257 Jad Zeitouni, Nosayaba Osazuwa-Peters, Yusuf Dundar, Gregory Zimet, Mark A. Varvares. (2025). Two decades of the HPV vaccine: its promise, progress, prospects, projections, and posterity, The Lancet Regional Health - Americas, (51), https://doi.org/10.1016/j.lana.2025.101243 Diabetes, Obesity and Metabolism 28, no. 6 (2026): 5043–5057, https://doi.org/10.1111/dom.70698. Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis. Am J Med. 2026 Jul;139(7):913-921. doi: 10.1016/j.amjmed.2026.03.010 US Preventive Services Task Force; Nicholson WK, Silverstein M, Wong JB, et al. Screening for breast cancer: US Preventive Services Task Force recommendation statement. JAMA. 2024;331(22):1918–1930. Trentham-Dietz A, Chapman CH, Jayasekera J, et al. Collaborative modeling to compare different breast cancer screening strategies: a decision analysis for the US Preventive Services Task Force. JAMA. 2024;331(22):1931–1946. Giaquinto AN, Sung H, Miller KD, et al. Breast cancer statistics, 2022. CA Cancer J Clin. 2022;72(6):524–541. Qaseem A, Harrod CS, Balk EM, et al. Screening for breast cancer in asymptomatic, average-risk adult females: a guidance statement from the American College of Physicians (Version 2). Ann Intern Med. 2026.: American Cancer Society. Breast Cancer Facts & Figures 2022–2024. Atlanta, GA: American Cancer Society, 2022. Hu X, Chehal PK, Kaplan C, et al. Racial differences in patient-reported symptoms and adherence to adjuvant endocrine therapy among women with early-stage, hormone receptor-positive breast cancer. JAMA Netw Open. 2022;5(8):e2225485. Torres JM, Sodipo MO, Hopkins MF, Chandler PD, Warner ET. Racial differences in breast cancer survival between Black and White women according to tumor subtype: a systematic review and meta-analysis. J Clin Oncol. 2024;42(35):4225–4234. Bailey ZD, Krieger N, Agénor M, Graves J, Linos N, Bassett MT. Structural racism and health inequities in the USA: evidence and interventions. Lancet. 2017;389(10077):1453–1463. Hypertension. 2026;83:00–00. DOI: 10.1161/HYPERTENSIONAHA.125.25787 Allen RH, Bartz D. Opill: The Over-the-Counter Contraceptive Pill. Obstet Gynecol. 2024;143(2):184-188. doi:10.1097/AOG.0000000000005455 Cahill EP, Kaur S. Advances in contraception research and development. Curr Opin Obstet Gynecol. 2020;32(6):393-398. doi:10.1097/GCO.0000000000000666 Charles DN, Nagarsheth M, Oshman L. Pain Management for IUD Insertion in Primary Care. Am Fam Physician. 2025;111(4):299-301. Chen, C., Strasser, J., Banawa, R., Luo, Q., Bodas, M., Castruccio-Prince, C., Das, K., & Pittman, P. (2022). Who is providing contraception care in the United States? An observational study of the contraception workforce. American journal of obstetrics and gynecology, 226(2), 232.e1–232.e11. https://doi.org/10.1016/j.ajog.2021.08.015 Diedrich,J., Klein, D. Peipert, J.(2017). Long-acting reversible contraception in adolescents: a systematic review and meta-analysis, Am J Ob Gyn, April 2017. http://dx.doi.org/10.1016/j.ajog.2016.12.024 Li RHW, Lo SST, Gemzell-Danielsson K, Fong CHY, Ho PC, Ng EHY. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023;402(10405):851-858. doi:10.1016/S0140-6736(23)01240-0 Mørch LS, Meaidi A, Corn G, Hargreave M, Wessel Skovlund C. Breast Cancer in Users of Levonorgestrel-Releasing Intrauterine Systems. JAMA. 2024;332(18):1578–1580. doi:10.1001/jama.2024.18575 Nguyen AT, Curtis KM, Tepper NK, et al. U.S. Medical Eligibility Criteria for Contraceptive Use, 2024. MMWR Recomm Rep. 2024;73(4):1-126. Published 2024 Aug 8. doi:10.15585/mmwr.rr7304a1 Paradise SL, Landis CA, Klein DA. Evidence Based Contraception: Common Questions and Answers. American Family Physician. 2022. https://www.aafp.org/afp/2022/0900/contraception The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
Dr. Christian Rodriguez joins the show straight from Pennington Biomedical, where he works alongside obesity research legends Eric Ravussin and Steve Heymsfield. He breaks down his new review on metabolically healthy obesity and why the old "zero metabolic syndrome criteria" definitions are so inconsistent. The conversation dives deep into the Lancet Commission's new obesity framework, comparing it to the ACE staging system and picking apart where each one falls short, including the controversial call to leave type 2 diabetes out of the "preclinical" category. Rodriguez also previews his upcoming study on people with a BMI of 60 and above, a group that's rarely studied because researchers aren't sure it's safe. The episode wraps with a candid discussion on GLP-1 stigma and why treating obesity early matters more than chasing a number on the scale. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Food as Medicine: Why Medical Nutrition Therapy and Medically Tailored Meals Belong in Modern Healthcare: Registered dietitian nutritionist Leyla Muedin argues that food should be treated with the same rigor as medication through medical nutrition therapy (MNT) and “diet prescriptions,” integrating nutrition into treatment plans rather than leaving it as optional advice. She cites evidence that medically tailored meals (MTMs) can improve outcomes and reduce costs, including a Health Affairs simulation estimating $23.7B in first-year net savings nationwide and a Nature Medicine analysis of a Massachusetts Medicaid demonstration (2020–2023) showing MTM recipients had 31% fewer hospitalizations, 20% fewer emergency visits, and $3,433 lower total healthcare costs, offsetting 98% of program costs. She discusses food insecurity, expanding Medicaid coverage via Section 1115 waivers, EHR integration, and how MTMs support adherence for conditions such as diabetes, cardiovascular disease, chronic kidney disease, depression, and IBS (including low FODMAP).
How a vegan turned to a No-Oil diet and reversed her diabetes in this reprise of the PETA Podcast. See more about Stephanie's story at PETA.org.
I have received a ton of requests to write about the paper “Are people with metabolically healthy ob*sity really healthy? A prospective cohort study of 381,363 UK Biobank participants” Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe
Do you suffer with anxiety, depression, or another mental illness? Millions of people do. The usual treatment is a prescription medication. If that doesn't work, the healthcare provider may offer a different one. Diet is certainly not the first topic on the provider's mind. But what if, in addition to appropriate pharmacological treatment, you were able to nourish, protect and energize your brain with your diet? Our guest offers evidence that you can heal your mind with a ketogenic approach to eating. We need to acknowledge that this approach is quite different from the plant-rich eating pattern advocated by last week's guest, Dr. Will Bulsiewicz. Humans around the world have adopted a wide range of dietary regimens that support health. Listen to Dr. Georgia Ede explain why she thinks a paleo or ketogenic diet is helpful for bolstering brain health. At The People's Pharmacy, we strive to bring you up to date, rigorously researched insights and conversations about health, medicine, wellness and health policies and health systems. While these conversations intend to offer insight and perspective, the content is provided solely for informational and educational purposes. Please consult your healthcare provider before making any changes to your medical care or treatment. How You Can Listen You could listen through your local public radio station or get the live stream at 7 am EST on Saturday, August 22, 2026, through your computer or smart phone (wunc.org). Here is a link so you can find which stations carry our broadcast. If you can't listen to the broadcast, you may wish to hear the podcast later. You can subscribe through your favorite podcast provider, download the mp3 using the link at the bottom of the page, or listen to the stream on this post starting on August 24, 2026. Can You Heal Your Brain with Food? We live in stressful times. More than 50 million Americans take prescription antidepressants, and millions more are on anti-anxiety medication. Unfortunately, while these drugs can be life savers, they don't always work as well as we would like. In some cases, antidepressants are only about 10 percent more effective than a placebo. Dr. Georgia Ede is a psychiatrist who began her investigation into how food affects mental health serendipitously. She was experimenting with her own diet to address some physical health issues. She used a food and symptom journal to discover the best dietary choices for her own health. To her surprise, the “upside-down” diet that helped her feel better physically also improved her sleep and her ability to focus. She started looking into evidence that a paleo or ketogenic diet could benefit people with mental health challenges. What Is Metabolic Psychiatry? There is evidence that people consuming unhealthy diets full of fast food or ultra-processed products are more susceptible to symptoms of anxiety (Nutrition Neuroscience, May 19, 2026). On the other hand, people participating in a supervised weight-loss program using either a low-carbohydrate ketogenic diet or a low-fat diet reported improvements in mood (Obesity, Jan. 2007). Those on the ketogenic (Atkins) diet reported less hunger and fewer unpleasant symptoms. Researchers have also tested a ketogenic diet in people with schizophrenia or bipolar disorder (Psychiatry Research, May 2024). These volunteers also had metabolic disorders, including obesity, which is often an unwanted effect of the ant-psychotic drugs they take to treat their condition. This four-month pilot study saw participants lose weight, reduce insulin resistance and lower their triglycerides. Even more impressive, they had a 32 percent reduction in the Brief Psychiatric Rating Scale. They also reported better sleep and improved life satisfaction. You may find this recent article from National Geographic of interest: https://www.nationalgeographic.com/health/article/metabolic-psychiatry-keto-diet-brain-science. Unfortunately, it might be behind a paywall. How Does Food Affect Our Brains? Most of our body tissues are accustomed to getting energy from glucose, with the help of insulin. However, years of exposure to high levels of these compounds often makes the tissues less sensitive to the effects of insulin. The consequence is that the body–and therefore also the brain–is flooded with high levels of glucose. This exposure can result in the formation of advanced glycation end products in the brain, which can be harmful. The brain evolved to use either glucose or a flexible mix of glucose and ketones. These are the result of burning fat rather than sugar. A paleo diet will naturally provide more ketones and less glucose. Dr. Ede and colleagues have found that a ketogenic diet can be very helpful even for people with relatively serious mental problems. In one study (which was not placebo-controlled), patients hospitalized with severe persistent mental illness were given a ketogenic diet. Most did well and had significant improvements in their depression and psychosis symptoms (Frontiers in Psychiatry, July 6, 2022). Is Ketosis Dangerous? Ketosis itself simply means that you are burning fat as fuel rather than sugar. This can be achieved by following a diet that is high in animal fat, with moderate amounts of animal protein and low amounts of carbohydrate derived from plant foods. Ketosis is not inherently dangerous. However, Dr. Ede urges anyone who wants to heal their brain with diet to ask a healthcare provider to monitor and supervise the process. Prescription drug doses may require adjustment, and people may need support as they adopt a paleo or ketogenic diet. That is why this is not a do-it-yourself approach. Is Coconut Oil Helpful to Heal Your Brain? Dr. Ede described the benefits of medium-chain fatty acids produced in digesting fat. You may recall a video from a few years back in which a doctor described helping her husband recover from Alzheimer disease, at least partially, by giving him coconut oil. Some researchers consider Alzheimer disease to be a form of diabetes because the AD brain does not metabolize sugar effectively. Dr. Ede suggested that the benefits may be real, but getting medium-chain fatty acids from the diet rather than be taking coconut oil might be preferable. After Dr. Ede told us about Fran, who overcame significant memory problems by changing to a ketogenic diet, we hope there will be trials on this. Future Trials on Diet to Heal Your Brain Dietary trials are notoriously difficult to conduct. People often don't stick to the prescribed diet, and it can be difficult to find an appropriate placebo for comparison. Nonetheless, Dr. Ede is looking forward to results from a large trial of the keto diet for people with schizophrenia or bipolar disorder. This study is being conducted in Australia. This Week’s Guest Dr. Georgia Ede is a globally recognized expert in nutritional and metabolic psychiatry. Her 25+ years of clinical experience include 7 years at Harvard University, where she was the first psychiatrist to offer nutrition-based approaches to mental health conditions. Dr. Ede co-authored the first inpatient study of the ketogenic diet for serious mental illness, developed the first medically accredited course in ketogenic diets for mental health, and is a recipient of the Baszucki Metabolic Mind Award. Current research collaborations include pilot studies in pediatric bipolar disorder, adult ADHD, and PTSD. Her internationally bestselling book Change Your Diet, Change Your Mind: A Powerful Plan to Improve Mood, Overcome Anxiety, and Protect Memory for a Lifetime of Optimal Mental Health is being translated into 11 languages and is recommended by the New York Times Book Review. The People's Pharmacy is reader supported. When you buy through links in this post, we may earn a small affiliate commission (at no cost to you). Dr. Georgia Ede, author of Change Your Diet, Change Your Mind Listen to the Podcast The podcast of this program will be available Monday, August 24, 2026, after broadcast on Aug. 22. In this week's podcast, we'll learn how vegetarians can follow a ketogenic diet. How does the evidence Dr. Ede has collected accord with the chemical imbalance theory of mental illness? We also discuss why the standard American diet is not good for mental wellbeing, and we find out what might be in Dr. Ede's own shopping cart. You can stream the show from this site and download the podcast for free. Download the mp3, or listen to the podcast on Apple Podcasts or Spotify.
Episode 26-33 Is Insulin Resistance The Greatest Threat To Your Health? Nearly EVERY chronic disease is strongly linked to Insulin Resistance. Or, stated another way… As you age, Insulin Resistance may be THE factor that causes you to suffer with one or more of the following conditions: High Blood Pressure, Diabetes, Alzheimer's, Stroke, Parkinson's, Fibromyalgia, Multiple Sclerosis, Obesity, Heart Disease, Autoimmune Disorders, Vision Problems, Kidney Failure, Neuropathy, Bipolar Disorder, Depression. On this episode I address the basics regarding Insulin Resistance. Specifically I ask 5 questions that you need to know the answers to should you desire to live a long and HEALTHY life: 1) What is Insulin Resistance? 2) Why is it so harmful? 3) What causes it? 4) How can it be corrected? 5) How do you know if you have it? Give this episode a good listen if you want to prevent, and possibly reverse, Insulin Resistance and the negative health consequences that come with it. And, as always, be sure to share this episode with a friend. Thanks! ———————- Want to learn more? Continue the conversation regarding this episode, and all future episodes, by signing up for our daily emails. Simply visit: GetHealthyAlabama.com Once there, download the "Symptom Survey" and you will automatically added to our email list. ———————- Also, if you haven't already, we'd appreciate it if you'd subscribe to the podcast, leave a comment and give us a rating. (Thanks!!!) * This podcast is for informational and educational purposes only. It is not intended to diagnose or treat any disease. Please consult with your health care provider before making any health-related changes.
Could GLP-1 medications eventually cost just $40 to $50 per month? Hims & Hers CEO Andrew Dudum thinks so, and if he's right, it could completely change access to obesity treatment in America.But getting there may depend on something most patients have never heard of: the global peptide manufacturing supply chain.In this episode of The Weekly Dose from On The Pen, Dave Knapp, Man on the Mounjaro, breaks down one of the biggest weeks in GLP-1 and obesity medicine news, including the surprising role of Chinese pharmaceutical manufacturer WuXi AppTec, which Bloomberg described as having a “GLP-1 chokehold” while U.S. policymakers wrestle with reducing America's dependence on Chinese biotechnology.We also dig into one of the strangest GLP-1 stories of the year. Amylyx Pharmaceuticals just reported positive Phase 3 results for avexitide, a GLP-1 receptor antagonist, meaning it actually BLOCKS GLP-1. The drug reduced serious hypoglycemic events by 55% in patients with post-bariatric hypoglycemia, a debilitating condition that can occur after gastric bypass surgery.Then we get personal.Online personality Clavicular recently described becoming apathetic while taking a high dose of retatrutide, renewing the conversation around GLP-1 medications, anhedonia, emotional blunting, dopamine and reward signaling. Dave has firsthand experience with anhedonia during GLP-1 treatment and previously discussed that experience as part of coverage on the Today Show.At what point does turning down food noise start turning down everything else?We also examine Serena Williams' return to professional tennis while openly using Zepbound (tirzepatide) and the growing debate over whether GLP-1 medications could ever be considered performance-enhancing drugs in professional sports.Plus, new research suggests GLP-1 medications and significant weight loss may improve testosterone levels and fertility markers in men with obesity-related low testosterone, raising important questions about metabolic health, hypogonadism and when testosterone replacement therapy may or may not be appropriate.In this episode:
Low-fat dairy shown to confer no weight, cholesterol benefits over full-fat dairy; FDA and USDA to define ultra-processed foods for first time—but what are they really? Newly discovered tick-borne Bourbon virus can be fatal—but is it more pervasive than we think? Thorne supplement maker—sold 3 years ago for $700 million—acquired by Procter & Gamble for $3.8 billion. Those dark skin blotches—are they melasma, or just age spots? Is low-mercury salmon a hype? That fishy smell—does it mean your seafood is spoiled?
The Aubrey Masango Show is presented by late night radio broadcaster Aubrey Masango. Aubrey hosts in-depth interviews on controversial political issues and chats to experts offering life advice and guidance in areas of psychology, personal finance and more. All Aubrey’s interviews are podcasted for you to catch-up and listen. Thank you for listening to this podcast from The Aubrey Masango Show. Listen live on weekdays between 20:00 and 24:00 (SA Time) to The Aubrey Masango Show broadcast on 702 https://buff.ly/gk3y0Kj and on CapeTalk between 20:00 and 21:00 (SA Time) https://buff.ly/NnFM3Nk Find out more about the show here https://buff.ly/lzyKCv0 and get all the catch-up podcasts https://buff.ly/rT6znsn Subscribe to the 702 and CapeTalk Daily and Weekly Newsletters https://buff.ly/v5mfet Follow us on social media: 702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/Radio702 702 on YouTube: https://www.youtube.com/@radio702 CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/CapeTalk CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.
Monash University obesity expert Professor Michael Cowley joined Tom Elliott to discuss the possibility of publicly subsidised weight loss drugs to improve the overall health of Australians.See omnystudio.com/listener for privacy information.
There's a hidden fat that matters more for your health than your weight. This is visceral fat: it wraps around your organs, raises your risk of heart disease and cancer, and builds up even in people who look slim and healthy. In today's episode, Professor Jimmy Bell, a world-leading expert in measuring visceral fat, explains how we can shrink this dangerous belly fat in just 12 weeks. Jimmy explores why two people can weigh exactly the same and carry completely different amounts of this hidden fat, what it is, where it hides and why it matters. By the end, you'll have a completely new understanding of body fat, and what it really means for your long-term health. If your weight has stayed exactly the same for years, what do you think is happening underneath it?
Vaccine Education Center | Children's Hospital of PhiladelphiaEmail the show at kids@mpbonline.orgHost: Dr. Morgan McLeod, Asst. Professor of Pediatrics and Internal Medicine at the University of Mississippi Medical Center.If you enjoyed listening to this podcast, please consider contributing to MPB: https://donate.mpbfoundation.org/mspb/podcast Hosted on Acast. See acast.com/privacy for more information.
Turns out that there's something that almost all of us consume that negatively affects our body whether we eat it or not.
Episode 26-32 Insulin Resistance- The "Silent Killer" You Probably Have, But Don't Know It Do you have Insulin Resistance? That's a question you should know the answer to. Why? Because Insulin Resistance is linked to nearly every major chronic disease. Diseases such as High Blood Pressure, Diabetes, Alzheimer's, Stroke, Parkinson's, Fibromyalgia, Multiple Sclerosis, Obesity, Heart Disease, and Autoimmune Disorders. Insulin Resistance is also something very few doctors talk about. Why? I honestly don't know. But what I DO know is this: YOU need to know about Insulin Resistance… AND you need to know how to find out whether or not you have it. This is especially true if you are over the age of 30 as the majority of American adults HAVE Insulin Resistance and don't even know it! On this episode I talk about Insulin Resistance and how to determine if you have it. Give this episode a good listen and, as always, be sure to share it with a friend. Thanks! ———————- Want to learn more? Continue the conversation regarding this episode, and all future episodes, by signing up for our daily emails. Simply visit: GetHealthyAlabama.com Once there, download the "Symptom Survey" and you will automatically added to our email list. ———————- Also, if you haven't already, we'd appreciate it if you'd subscribe to the podcast, leave a comment and give us a rating. (Thanks!!!) * This podcast is for informational and educational purposes only. It is not intended to diagnose or treat any disease. Please consult with your health care provider before making any health-related changes.
Disclaimer: This episode and article are for educational purposes only and are not a substitute for individualized medical advice. Always consult your physician before making changes to your diet, exercise routine, or medications.TL;DR* The CDC's top 10 causes of death account for roughly 74% of all deaths in the US each year, and up to 80% of chronic disease is estimated to be driven by lifestyle factors — diet, movement, sleep, stress, and toxin exposure. * This episode goes cause by cause (heart disease, cancer, COVID/respiratory disease, accidents, stroke, Alzheimer's, diabetes, kidney disease, flu/pneumonia, and suicide) and lays out what the peer-reviewed research says about preventing, slowing, or reversing each one.* Ready to build your own plan? Book a free Metabolic Blueprint Session →The List, and the Number That Should Keep You Up at NightAccording to the CDC, ten conditions account for about 74% of all deaths in the United States every year:* Heart disease* Cancer* COVID-19 / chronic lower respiratory diseases* Accidents (unintentional injuries)* Stroke* Alzheimer's disease* Diabetes* Kidney disease* Influenza and pneumonia* SuicideHere's the part that doesn't get said enough: research estimates that up to 80% of chronic disease is driven by lifestyle factors — diet, movement, sleep, stress, and toxin exposure. Those aren't destinies. They're decisions, and decisions can change.A landmark paper in the Journal of the American Medical Association found that poor diet alone accounts for more deaths in the US than tobacco use. The fork may be more dangerous than the cigarette. And yet, most patients who end up on four to six medications were never once asked what they eat, how they sleep, or whether they move their bodies before those prescriptions were written. That's the difference between a sick care system and a healthcare system.Heart Disease and Stroke: The Most Reversible Disease We KnowHeart disease kills one American every 34 seconds and has held the #1 spot for over a century. But it's also one of the most reversible conditions in medicine.In 1990, Dr. Dean Ornish's landmark Lifestyle Heart Trial showed that intensive lifestyle changes — diet, exercise, stress management, and social support — could reverse coronary artery disease without drugs or surgery. Arterial plaques reduced. Blood flow improved. Chest pain decreased. A 2019 study in the Journal of the American College of Cardiology confirmed it: a plant-predominant diet, regular aerobic exercise, not smoking, and a healthy weight reduced cardiovascular risk by over 80%.What that looks like in practice:* A Mediterranean or whole-food, plant-based diet rich in omega-3s and antioxidants (this isn't the only diet that works — it's the broadest evidence-backed baseline)* Zone 2 cardio (low-intensity aerobic work, three to five times a week — a brisk walk counts)* Managing chronic inflammation, the real driver of arterial plaque formation* Reducing refined sugar and seed oils, which damage the endothelial lining of the arteries* Prioritizing sleep, since poor sleep spikes cortisol and directly harms the heartStroke follows the same playbook: control blood pressure through diet, exercise, and stress reduction. The DASH diet in particular has been shown in multiple studies to lower blood pressure as effectively as medication in many patients.Cancer: 30–50% Preventable, and Possibly More Metabolic Than GeneticTo be clear, this isn't a claim about curing cancer — it's about how much prevention research is available and underused. The World Health Organization estimates that 30–50% of cancers are preventable. The American Institute for Cancer Research has identified lifestyle factors that dramatically reduce risk across multiple cancer types:* Diet. A 2022 meta-analysis in The Lancet linked poor dietary patterns — low fiber, low fruit/vegetable intake, high processed meat — to one in five cancer deaths globally.* Obesity. Excess weight is now the second-leading risk factor for cancer after smoking, because fat tissue is metabolically active and produces hormones like estrogen and inflammatory cytokines that fuel cancer growth.* Exercise. A 2019 study of over 1.4 million people found higher physical activity was associated with lower risk across 13 cancer types, including breast, colon, and endometrial cancer.* Fasting and metabolic health. Emerging research on intermittent fasting and time-restricted eating shows it can lower insulin-like growth factor, a key promoter of cancer cell proliferation.* Toxin reduction. Chronic low-grade exposure to pesticides, plastics (BPA, phthalates), and environmental pollutants has been linked to increased cancer risk. Choosing organic where possible, filtering water and air, and reducing plastic in cookware and storage all matter.There's also a deeper shift happening in how researchers understand cancer itself. It's long been treated primarily as a genetic disease, but the evidence is increasingly pointing toward cancer as a metabolic disease. Dr. Thomas Seyfried at Boston College has done groundbreaking work showing that cancer cells overwhelmingly rely on glucose and glutamine fermentation for energy — which is why a ketogenic or low-glycemic approach may help starve cancer cells while protecting healthy ones. The research is still evolving, but it's compelling.Think of your body like a garden. You can water it, enrich the soil, and pull the weeds — or you can dump sugar and chemicals on it and wonder why nothing grows right. Disease doesn't happen to you. It grows in an environment you create, consciously or not. The good news: you can change that environment starting today.Alzheimer's: “Type 3 Diabetes”Alzheimer's is rising, and it's terrifying to watch someone go through it. But emerging science shows it has a strong lifestyle and metabolic component — researchers now sometimes call it “type 3 diabetes” because of the profound link between insulin resistance and neurodegeneration.Dr. Dale Bredesen's ReCODE Protocol, published in the Journal of Aging, showed that a multimodal lifestyle intervention — diet, exercise, sleep optimization, hormone balancing, and stress reduction — reversed early cognitive decline in the majority of patients treated. In his 2014 case series, 9 of 10 patients with early Alzheimer's or mild cognitive impairment showed measurable improvement, with several returning to work.Key strategies from the research:* Sleep is non-negotiable. The brain's glymphatic (waste clearance) system activates primarily during sleep, flushing out amyloid beta plaque. Poor sleep means plaque buildup.* Exercise. A 2020 study showed aerobic exercise increases BDNF (brain-derived neurotrophic factor) — essentially fertilizer for neurons — and reduces dementia risk by up to 35%.* Mediterranean-MIND diet. Shown to slow cognitive aging by an estimated 7.5 years in adherent individuals.* Blood sugar management. Insulin resistance in the brain disrupts its ability to use glucose for energy, effectively starving neurons.* Social connection. Harvard's 80-year longitudinal study found relationship quality was the single strongest predictor of cognitive health and longevity in old age.Type 2 Diabetes and Kidney Disease: One Disease Driving AnotherOver 37 million Americans have type 2 diabetes, and another 96 million are pre-diabetic. Here's the part that surprises people: type 2 diabetes is reversible in the majority of cases, and this isn't controversial — the science is overwhelming.The 2019 DiRECT trial, published in The Lancet, found that nearly half of type 2 diabetics achieved full remission through an intensive dietary intervention alone, with no medication. Other studies using low-carbohydrate and very-low-calorie diets have replicated these results consistently.Diabetic nephropathy — kidney damage from chronically high blood sugar — is the leading cause of kidney failure in the US. Control the upstream issue (blood sugar and metabolic dysfunction) and you protect the downstream organ.The diabetes reversal framework from the research:* Dramatically reduce refined carbohydrates and added sugars to blunt insulin spikes and reduce fat storage in the liver and pancreas* Practice time-restricted eating or intermittent fasting to improve insulin sensitivity* Add resistance training — muscle is your biggest glucose sink, so more muscle means better blood sugar control* Reduce visceral fat (the fat around and inside your organs), a key driver of insulin resistance and inflammationIf this list feels like a lot, that's fair. But it's not about blame — it's about empowerment. You have more control over your health outcomes than the medical system has typically told you.Respiratory Disease, Flu, and PneumoniaChronic lower respiratory diseases like COPD and emphysema are largely driven by smoking and air quality. Quitting smoking remains the single most impactful intervention here, full stop.For flu and pneumonia risk, immune resilience matters: vitamin D optimization, zinc and elderberry, and gut microbiome health (roughly 70% of your immune system lives in your gut). Even mild sleep deprivation has been shown to quadruple susceptibility to viral infection.Suicide and Mental HealthThis is the cause of death nobody wants to talk about, but it's in the top 10 — and it's the leading cause of death for men under 50, and the second-leading cause of death for people ages 10–34.While this is complex and deeply personal, research points to several lifestyle levers:* Exercise functions as an effective antidepressant, largely through endorphin release* The gut-brain axis matters more than most people realize — over 75% of the body's serotonin is produced in the gut, so gut health directly shapes brain chemistry* Social connection and purpose. Viktor Frankl's Man's Search for Meaning, written while he was in a Nazi concentration camp, captured this: meaning and connection to purpose are essential for survival, and perspective shapes both physiology and outcome* Reducing alcohol, a central nervous system depressant that worsens anxiety and depression despite short-term reliefIf you or someone you love is struggling, crisis hotlines are available 24/7. There's often a reason it's happening, and there's often a way through it.The Common ThreadAcross every single one of these conditions — heart disease, stroke, cancer, Alzheimer's, diabetes, kidney disease, respiratory disease, immune function, mental health — the same five levers keep showing up: diet, exercise, sleep, toxin reduction, and blood sugar balance.Your daily habits are either building disease or building resilience. Every meal, every walk, every night of good sleep compounds — just like interest in a bank account.This Week's Action Plan* Do a food audit. For the next three days, write down everything you eat. No judgment, just awareness — you can't change what you can't see.* Walk 30 minutes a day. It lowers blood pressure, improves insulin sensitivity, boosts BDNF, and reduces cortisol. Simple, not easy — do it anyway.* Optimize your sleep. Consistent bedtime, dark room, cool temperature, no screens.* Get your labs done. Know your fasting glucose, A1C, CRP, vitamin D, triglycerides, and LDL — these are your early warning systems.* Address one stress source this week. A conversation you need to have, a boundary you need to set, or ten minutes of breathwork. Chronic stress is silently killing you — take action on it.Ready for a Real Plan?If you're ready to take your health seriously and want a clear roadmap instead of guesswork, book a Metabolic Blueprint Session. In 30–45 minutes, we'll walk through your top three priority areas and how programs like the Metabolic Momentum Accelerator, the Cellular Reboot Accelerator, and the Total Health Restore Protocols can help.Schedule your complimentary consult →Know someone this could help? Share this episode with them — it might change or even save their life.If this episode was valuable, leaving a review on Spotify or Apple Podcasts helps this show reach more people.ReferencesStudies and sources cited in this episode:* CDC — Leading Causes of Death data* Journal of the American Medical Association (JAMA) — poor diet and US mortality* Ornish, D. et al. (1990) — The Lifestyle Heart Trial* Journal of the American College of Cardiology (2019) — plant-predominant diet, exercise, and cardiovascular risk reduction* DASH diet research on blood pressure control* World Health Organization (WHO) — cancer preventability estimates* American Institute for Cancer Research — lifestyle and cancer risk* The Lancet (2022 meta-analysis) — dietary patterns and cancer deaths* Physical activity and cancer risk study (2019, ~1.4 million participants)* Seyfried, T., Boston College — cancer as a metabolic disease* Bredesen, D., Journal of Aging — the ReCODE Protocol; 2014 case series* BDNF and exercise study (2020) — dementia risk reduction* Mediterranean-MIND diet and cognitive aging research* Harvard Study of Adult Development (80-year longitudinal study) — relationships and longevity* DiRECT Trial, The Lancet (2019) — type 2 diabetes remission through dietary intervention* Frankl, V. — Man's Search for MeaningThis article summarizes claims and studies as presented in the podcast episode. Listeners are encouraged to review primary sources directly and consult their own physician before making health decisions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit tripleplaydoc.substack.com/subscribe
Two experts in obesity medicine discuss the latest advances in obesity care, including: Current data for incretin-based therapies Beyond the scale—individualizing OMM selection based on weight-related comorbidities and cardiometabolic risk Common contraindications and warnings associated with certain OMMs Shared decision-making strategies to inform treatment selection. [JF1]Added this to the episode notes to maybe help with the posttest Presenters Amy Butts, PA-C, DFAAPA, BC-ADM, CDCES Endocrine Physician Associate WVU Medicine Wheeling Hospital Immediate Past President of American Society of Endocrine Physician Associates Wellsburg, West Virginia Nicholas Pennings, DO Professor of Family Medicine Campbell University School of Osteopathic Medicine Director of Clinical Education Obesity Medicine Association Buies Creek, North Carolina Link to full program:https://bit.ly/4v7eIY4 Get access to all of our new podcasts by subscribing to the Decera Clinical Education Multispecialty Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The medicines regulator says it has recorded just over 1500 adverse reactions to the anti-obesity injections known as GLP-1s. Expert in managing obesity, Professor Donal O'Shea talks about some of the side effects he's seen.
P.M. Edition for Aug. 10. The FDA has laid out new rules intended to make the food system more transparent, part of an overhaul promised by Health Secretary Robert F. Kennedy Jr. WSJ reporter Liz Essley Whyte discusses how the new rules would work and why guidelines for ultraprocessed foods didn't come today. Plus, as Iran strengthens its demands in negotiations to reopen the Strait of Hormuz, Gulf states have begun accepting a new reality: that Tehran will control the strait for the foreseeable future. We hear from WSJ Middle East correspondent Benoit Faucon about what they are doing about it. And more than 70 people have been killed in a 7.4 magnitude earthquake in Colombia. Alex Ossola hosts. Sign up for the WSJ's free What's News newsletter. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Welcome to the latest episode (August 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Updates: Hirsh Elhence, Jennifer L. Dodge, Stephen Fuest, et al. National Prevalence of Clinical Obesity by BMI Class: A National Cross-Sectional Study. Ann Intern Med. [Epub 2 June 2026]. doi:10.7326/ANNALS-25-05287 Eva Johnsen, et al. Achieving at Least 15% Weight Loss Within 2 Years of Type 2 Diabetes Diagnosis Is Associated With Lower Risks of Macrovascular and Microvascular Complications: A U.K. Cohort Study. Diabetes Care 20 July 2026; 49 (8): 1480–1489. doi.org/10.2337/dc26-0937 Carel W. le Roux, et al. Survodutide Once Weekly for the Treatment of Adults with Obesity. The New England Journal of Medicine June 2026 DOI: 10.1056/NEJMoa2600751 Yu Wang, Shichao Tang, Xilin Zhou, Ping Zhang. National Trends in Out-of-Pocket Cost for Glucose-Lowering Drugs Among U.S. Adults With Diabetes, 2000–2022. Diabetes Care 20 July 2026; 49 (8): 1414–1419. https://doi.org/10.2337/dc25-2040 Jelle M. Beernink, et al. Effect of Finerenone on Albuminuria in Type 1 Diabetes by Baseline HbA1c Level and Diabetes Duration: An Exploratory Analysis of the FINE-ONE Trial. Diabetes Care 20 July 2026; 49 (8): 1434–1441. https://doi.org/10.2337/dc26-0882 Welch M, Forst T, Jia W et al. Orforglipron compared with dapagliflozin in adults with type 2 diabetes and inadequate glycaemic control with metformin (ACHIEVE-2): a multicentre, randomised, non-inferiority, open-label, phase 3 trial. The Lancet, 2026; 408, 125-140 DOI: 10.1016/S0140-6736(26)00800-7 Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health DOC Updates is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's three science and medical journals—Diabetes, Diabetes Care, and Diabetes, Obesity, and CardioMetabolic CARE. Intended for practicing physicians and health care professionals, DOC Updates discusses how the latest research is relevant in clinical practice. For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, click here.
With the launch of a new journal, the American Diabetes Association (ADA) is also launching a brand new podcast: The Points of CARE, the official podcast of Diabetes, Obesity, and CardioMetabolic CARE. Join hosts Richard Beaser, MD and Jane Reusch, MD, as they highlight key research findings, clinical implications, and emerging themes across diabetes, obesity, and cardiometabolic health through interviews with journal authors and subject-matter experts. 1:15 Our hosts speak with Katherine R. Tuttle, MD, FASN, FACP, FNKF, Executive Director of Research at Providence Inland Northwest Health and a Professor of Medicine at the University of Washington School of Medicine. She is an author of the article "SGLT2 Inhibitors for the Primary Prevention of CKD in Type 2 Diabetes: A Systematic Review and Meta-analysis," available at doi.org/10.2337/doci26-0001. 8:50 Next, Richard introduces Alexander Turchin, MD, MS, Director of Informatics Research at the Division of Endocrinology at Brigham and Women's Hospital and Associate Professor of Medicine at Harvard Medical School. He is an author of "Trends in Diabetes Medications After Metformin in Patients at High Versus Moderate Cardiovascular Risk: The BESTMED Consortium 2014–2022," available for free at doi.org/10.2337/doc26-0027. 17:05 Richard and Jane highlight special material available in the latest issue of Diabetes, Obesity, and CardioMetabolic CARE. "Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults: Standards of Care in Overweight and Obesity—2026," available for free at doi.org/10.2337/doci26-0003 "Employment and Diabetes: A Statement of the American Diabetes Association," available for free at doi.org/10.2337/doc25-0092. 23:40 Finally, Richard and Jane highlight some of their favorite articles from the July-August issue. Vidovic, et al. Behavior Modifications From CUT-DM, Including Lifestyle Modification and Self-Efficacy doi.org/10.2337/doc25-0093 Chan, et al. Pharmacist-Driven Pre-Visit Planning to Optimize Prescribing in Type 2 Diabetes doi.org/10.2337/doc26-0019 Bannuru, et al. RAAS Inhibitors for the Primary Prevention of CKD in Type 1 and Type 2 Diabetes: A Systematic Review and Meta-analysis doi.org/10.2337/doci25-0014 Dimentstein, et al. Goals of Care Among Caregivers of Youths With Type 1 Diabetes doi.org/10.2337/doc26-0035 To learn more about Diabetes, Obesity, and CardioMetabolic CARE please visit diabetesjournals.org/docm-care. Thank you for listening, and don't forget to subscribe.
Over a week ago, I stood at 19,341 feet on the roof of Africa, Mount Kilimanjaro. It was the hardest thing I've ever done, harder than any Ironman or marathon. But somewhere between the rainforest and the summit, I realized I wasn't just climbing a mountain. I was watching my patients' weight loss journeys play out in front of me. In this episode, I'm sharing the first four lessons Kilimanjaro taught me about health, resilience, and what it actually takes to accomplish something hard. From the invisible prep work no one applauds, to why "pole pole" (slowly) is the secret to going further, this episode reframes what progress really looks like. Your summit isn't built in one dramatic moment. It's built in thousands of small, unglamorous decisions, the walk after dinner, the water instead of soda, the appointment you finally book. You'll learn why plateaus and slow progress aren't failures, why community and encouragement matter as much as calories, and why the hardest and most important step is simply saying yes. Episode Highlights: Why the journey begins long before the mountain, or the diet, ever starts The invisible decisions behind every success story nobody sees Lesson two: why "pole pole" (slowly) is the pace that actually gets you there Why our culture's obsession with fast results works against how bodies really change Lesson three: why encouragement on the journey matters as much as the plan itself Lesson four: why saying yes before you feel ready is the hardest and most important step Why no single meal, workout, or medication changes your life, consistency does The one question to ask yourself this week to keep moving forward Connect with Dr. Alicia Shelly: Website | drshellymd.com Facebook | www.facebook.com/drshellymd Instagram | @drshellymd Linked In | www.linkedin.com/in/drshellymd Twitter | @drshellymd About Dr. Alicia Shelly Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH. Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014. In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss, where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, "Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''. Resources: FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!)
Researchers are hopeful they are on the cusp of an obesity treatment that might represent a new way to lose weight. Unlike drugs such as Wegovy and Mounjaro, which suppress appetite and can result in the loss of muscle mass, this new treatment would target the body's fat-storage proceses and leave the appetite untouched. Professor Peter Shepherd, from the University of Auckland, spoke to Ingrid Hipkiss.
Over half of mature light-breed horses in the U.S. are obese — an incidence…
Over half of mature light-breed horses in the U.S. are obese — an incidence that's among the highest in the world. For most of them, the problem is equine metabolic...
Mendel Krashunsky is the founder of the Frum Health Club, a worldwide movement pushing Yidden to finally take their health seriously. He opens up about losing his father, an oligarch who lived a life of total luxury, to a preventable illness at just 38 years old, and how the grief sent Mendel into his own spiral of emotional eating that left him 70 pounds overweight and battling GERD before he'd even turned 20. From there, Mendel and Nachi dig into why health gets treated as optional in frum life, even though it's a mitzvah straight from the Torah, covering ultra-processed food, GLP-1s like Ozempic, how to talk to kids about it, and the viral 10,000-steps-a-day challenge that's grown into a global movement with tens of thousands of followers. It's a raw, practical conversation about food, faith, and why taking care of your body isn't a contradiction to Yiddishkeit, it's part of it. Join the Frum Health Club 30-Day Step Challenge!
Welcome! And thank you for listening. In this episode, I sit down with Dr. Tro Kalayjian, a physician who has dedicated his career to helping people understand obesity, food addiction, and metabolic health. Dr. Tro shares his own journey with obesity, including losing more than 150 pounds after years of struggling with weight and following conventional approaches to nutrition. We discuss insulin resistance, low carbohydrate nutrition, intermittent fasting, food addiction, binge eating, and the ways shame and guilt can make weight loss even more difficult. We also explore the complex relationship between ketogenic diets, cholesterol, and metabolic health, and why individualized care and continued research are so important. Thanks as always for listening. Connect with Dr. Tro here: https://toward.health/providers/dr-tro-kalayjian/ https://www.youtube.com/c/DrTroKalayjian If you would like to join us. Check out the website at doctordulaney.com Email me with questions at jami@doctordulaney.com https://jamanetwork.com/journals/jamacardiology/article-abstract/2850256https://pmc.ncbi.nlm.nih.gov/articles/PMC4703484/ water distillers: https://mypurewater.com/?sld=jdulaney. discount code: cleanwaterforsophie
Obesity is a chronic disease affecting millions of people in the United States with projections indicating continued obesity rates and related comorbidities. Pharmacists are increasingly in the position to advise patients and provide safe and effective management of medications for healthy weight loss. It is imperative that pharmacists collaborate with patients and their providers to optimize weight management health outcomes. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.
In this episode the guys break down 5 easy ways to fix obesity that are sustainable long term — injecting more movement into your daily life in small ways, avoiding hyper-palatable drug-like processed foods, lifting weights occasionally (even just once or twice a week is enough), connecting through activity with friends and community, and turning off social media an hour before bed. They also discuss the obesity epidemic now hitting Italian kids as processed food arrived, the milkshake study on how belief changes physical response, Adam's internal battle between ego and caution while squatting, Sal's dad performing CPR for 15 minutes on a motorcycle accident victim, pneumatic gym equipment and why it beats traditional machines for explosive training, the Brick phone device Sal and his wife are using to block social media before bed, the sauna temperature and longevity data deep dive, and Butcher Box egg bites and the best things in their lineup. Then they answer questions from Instagram. Paleo Valley (organ complex): https://paleovalley.com/mindpump 15% off automatically applied at checkout. Organ complex discussed on air — freeze dried liver, heart and kidney capsules, nature's multivitamin. Butcher Box: https://butcherbox.com/mindpump No code needed. Free ribeyes, NY strip steaks or filet mignons in every order for a year plus $20 off first box. Egg bites and tater tots discussed on air. Our Place (non-toxic cookware): https://fromourplace.com Code: MINDPUMP for 10% off sitewide. Always Pan replaces 8 pieces of cookware. Forever chemical free, 100-day trial, free returns. LINKS Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia SPOTIFY TIMESTAMPS 0:00 - Intro 2:15 - 5 easy ways to fix obesity for the long term 2:46 - Tip 1: Walk more — pair it with habits you already have instead of scheduling workouts 10:57 - Tip 2: Avoid drug-like foods — processed food eaters consume 600 more calories per day in studies 16:03 - Tip 3: Lift weights occasionally — even 1-2 days a week produces dramatic results 19:31 - Tip 4: Connect through activity — community is the number one predictor of consistency 22:02 - Tip 5: Turn off social media an hour before bed — the Brick device Sal is using 32:33 - Paleo Valley organ complex — nature's multivitamin and who Sal recommended it to 34:28 - Italian kids obesity epidemic — how processed food arrived late and hit hard 38:03 - The milkshake study — how belief changes physical response 40:16 - Adam's internal battle under the bar — ego vs. caution vs. longevity 45:43 - Pneumatic gym equipment — why Kaiser machines are better for power training 49:58 - Adam cheated on Katrina in her dream and she's still processing it 56:24 - Sauna temperature and longevity data — the Finnish study and what the data actually shows 1:09:41 - Q&A: Best way to come off a GLP-1 and reverse diet 1:14:15 - Q&A: Can you gain mostly fat instead of muscle during a bulk if you overtrain? 1:15:32 - Q&A: How much training volume is optimal in a calorie deficit? 1:18:15 - Q&A: Best advice to remain patient and trust the process
Childhood obesity rates have risen dramatically over the past several decades, presenting a growing challenge for families and healthcare providers alike. In this episode of Chinese Medicine Matters, we explore childhood obesity through the lens of Traditional Chinese Medicine, examining the roles of constitution, Phlegm pathology, ultra-processed foods, sleep, stress, and lifestyle. The discussion also outlines TCM treatment principles, constitutional patterns, and practical approaches to supporting long-term health in children.You can access the article here: https://www.mayway.com/blogs/articles/obesity-in-children-a-modern-understanding-of-cm-treatment-preventionSee our Monthly Practitioner Discounts https://www.mayway.com/monthly-specialsSign up for the Mayway Newsletterhttps://www.mayway.com/newsletter-signupFollow ushttps://www.facebook.com/MaywayHerbs/https://www.instagram.com/maywayherbs/
The internet has no shortage of opinions about fitness...Unfortunately, many of the loudest voices are encouraging people to stay exactly where they are.In today's episode, we react to multiple viral fitness clips covering obesity, weight loss, accountability, body positivity, dating, nutrition, gym culture, and the state of health in America.Some creators make great points.Others... not so much.The goal isn't to shame anyone.The goal is to separate good advice from bad advice so people can make better decisions for their health, performance, and longevity.If we're serious about reversing the obesity epidemic, we have to be willing to challenge ideas—not just celebrate them because they're popular.Health isn't hate. Accountability isn't bullying.
Commentary by Dr. Cheng Liu.
The United States has witnessed a staggering rise in obesity beginning in the early 1980s, leading to a wide array of important health consequences including heart disease, diabetes, and premature death. In this episode of Healthy Dialogue, Host Derek C. Angus, MD, MPH, talks with Marion Nestle, PhD, MPH, Paulette Goddard Professor Emerita at New York University and influential author on food politics, for a candid conversation about how society became ensnared in the current obesity epidemic and what might untangle it. Related Content: Food Politics, Obesity, and the "Wicked Mess" We Are In
Sign Up for Our Plus SideZ GLP-1 Patient Support Group - $50https://forms.gle/aHvZiiBXFr6q7NQY7 Linktree Our Favorite Thingshttps://linktr.ee/theplussidezGLP-1 News: New Studies, Lawsuits & CompoundingWhat do the latest GLP-1 studies actually mean for patients?This week, Kim is joined by Maria Rising, GLP-1 advocate, creator of GLP-1 News Now, our special guest News Correspondent. After living with PCOS and surviving a stroke in her 20s, Maria became passionate about helping patients understand the science behind obesity, GLP-1 medications, and access to care.There isn't just one new GLP-1 study every week anymore. There are dozens. Maria follows the research, policy changes, and industry news so patients don't have to. Together, Kim and Maria break down the latest headlines and explain what they actually mean for people living with obesity and metabolic disease.In this episode:- Maria's journey with PCOS, stroke, and GLP-1 treatment- The latest GLP-1 studies and research- Compounding updates and current lawsuits- What new research means for patients- Obesity, metabolic health, and access to care- How to separate headlines from evidenceFor ongoing GLP-1 news, research, and access updates, be sure to subscribe to Maria's Substack and TikTok.TikTok: https://www.tiktok.com/@tirzepatidetalesSubstack: https://glp1newsnow.substack.comThe Plus SideZ Podcast is an educational podcast focused on obesity, metabolic health, and GLP-1 medications. This episode is for informational purposes only and is not medical advice. Always talk with your healthcare provider about questions regarding your treatment.Send us Fan Mail!Support the showKim Carlos, Executive Producer TikTokInstagram Kat Carter, Producer TikTokInstagram
The explosive growth of GLP-1 obesity drugs is creating a massive cold storage logistics boom, with FedEx, UPS, and DHL racing to build out healthcare supply chain capacity in a market they can't afford to miss. We explore the second and third-order investment opportunities that most investors are overlooking in the GLP-1 revolution.Today's Stocks & Topics: Comcast Corporation (CMCSA), Marke Wrap, Liberty ETFs, Apple Inc. (AAPL), Dividend Reinvestment, Taxes, The GLP-1 Ripple Effect: How Obesity Drugs Are Reshaping Logistics, Healthcare, and Supply Chains, Microsoft Corporation (MSFT), AstraZeneca PLC (AZN).Our Sponsors:* Check out Anthropic and use my code Claude.ai/invest for a great deal: https://www.anthropic.com* Check out Chilipad and use my code INVEST for a great deal: https://sleep.me* Check out Quince and use my code quince.com/INVEST for a great deal: https://www.quince.com* Check out TruDiagnostic and use my code INVEST20 for a great deal: https://www.trudiagnostic.comAdvertising Inquiries: https://redcircle.com/brands
Could your weight gain and non-stop thoughts about food actually come from a rare condition you were born with? In this episode of the Docs Who Lift podcast, Dr. Spencer Nadolsky and Dr. Karl Nadolsky chat with weight expert Dr. Jesse Richards about Bardet-Biedl Syndrome (BBS). This rare condition tricks your brain into thinking your body is starving, even when you have plenty of body fat stored up. They talk about how doctors figure out if someone has BBS, an easy math trick to check your risk, and why normal diets or standard weight-loss shots do not always work for this condition. Plus, you will learn about special medicines that fix the brain's hunger signals when nothing else seems to work! In This Episode, You Will Learn: What Bardet-Biedl Syndrome (BBS) is and why many doctors miss it. Clear physical signs to look for, like extra fingers or toes, vision loss, and weight gain that starts very early in life. An easy formula to check your risk using your weight and your daily thoughts about food. The big difference between normal food cravings and extreme, non-stop hunger. Why special medicines can fix brain signals when regular weight-loss tools fail. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Your liver and blood sugar are far more connected than most people realize. In this episode, Nurse Doza walks through five links between the two: how the liver stores and releases glucose, where insulin resistance actually begins, how stress and cortisol raise blood sugar without food, how all of it lands on your mitochondria, and what obesity has to do with the whole picture. Featured Product The Metabolic Pack bundles the three formulas this episode keeps circling back to: Liver Boost to support phase I and phase II liver detoxification pathways, Mitochondriac for resveratrol, quercetin and pterostilbene to support cellular energy production, and Zen to support a healthy stress and cortisol response. Liver, cellular energy, and stress — supported together in one simple daily protocol. Suggested use: 2 Liver Boost, 1 Mitochondriac, and 1 Zen daily with food.
Dr. Austin Baraki joins me to challenge the popular narrative that testosterone levels are collapsing across society and to examine what the available evidence actually shows.Austin joins me to discuss:• Whether men's testosterone levels have declined dramatically in recent decades• Where the testosterone-decline narrative originated• Why viral claims often move faster than the evidence• How obesity, alcohol consumption, sleep loss, and socioeconomic deprivation can affect testosterone• Whether pesticides, fluoride, plastics, deodorant ingredients, seed oils, or polyester clothing meaningfully affect testosterone• The relationship between red meat, cholesterol, saturated fat, and testosterone• Why many environmental and lifestyle factors matter more for overall health than for testosterone specifically• How the testosterone conversation also applies to women• Whether differences within the normal physiological testosterone range meaningfully affect muscle growth or health• Why temporary hormonal increases after strength training do not necessarily produce more muscle growth• Acute changes in testosterone, growth hormone, insulin, and cortisol• When someone should consider having their testosterone levels checked• Which health conditions should be evaluated alongside possible hormonal concerns• Why laboratory results need to be interpreted alongside symptoms and clinical context• Why testosterone replacement therapy can be both overprescribed and underprescribed• And much moreFollow Austin on Instagram:@austin_barbellmedicineCHAPTERS02:10 The Testosterone Decline Myth06:37 Breaking Down Viral Claims08:03 An Evidence-First Framework11:15 Sponsor: Active Life12:26 Rapid-Fire Testosterone Villains16:24 Saturated Fat and Testosterone20:06 The Real Risk From Plastics21:52 Sponsor: MacrosFirst22:55 Seed Oils and Testosterone33:08 The Health Factors That Matter Most35:15 Obesity, Sleep Apnea, and Testosterone36:47 Alcohol and Lifestyle Evaluation37:44 Sleep Loss and Testosterone38:46 Extreme Diets Versus the Big Levers40:35 Optimization Versus Real Life42:07 Symptoms and Clinical Probability44:28 Specific Versus Vague Symptoms46:57 Misdiagnosis and Proper Medical Workup49:50 Hormonal Responses to Strength Training55:10 Why Laboratory Results Need Context01:01:44 Women and Testosterone Therapy01:06:31 Why TRT Is Mis-Prescribed01:09:32 When to Test Your Testosterone01:11:31 Final Thoughts and Book RecommendationSUPPORT THE SHOWIf this episode helped you better understand testosterone, hormonal health, or testosterone replacement therapy:• Subscribe and check out more episodes• Share the episode on social media and tag @andrewcoatesfitness• Send it to someone who is worried that modern life is destroying their testosteroneFOLLOW ANDREW COATESInstagram: @andrewcoatesfitnesshttps://www.andrewcoatesfitness.comPARTNERS AND RESOURCESRP STRENGTH APPUse code COATESRP:https://www.rpstrength.com/coatesJUST BITE ME MEALSUse code ANDREWCOATESFITNESS for 10% off:https://justbitememeals.comMACROSFIRST — FREE PREMIUM TRIAL• Download MacrosFirst• Begin setting up your account• When asked, “How did you hear about us?” enter: ANDREWKNKG BAGS — 15% OFFhttps://www.knkg.com/Andrew59676VERSA GRIPPShttps://www.versagripps.com/andrewcoatesTRAINHEROIC — FREE 90-DAY TRIAL• Visit: https://www.trainheroic.com/liftfree• Reply to the email you receive or email trials@trainheroic.com• Let them know Andrew sent youL1 BIOMECHANICS AND ASSESSMENT COURSEUse code COATES:https://pro.activelifeprofessional.com/assessmentworkshopevents
In this special crossover episode, recorded live at the American Diabetes Association's Scientific Sessions in New Orleans, the hosts of the ADA's professional podcasts—DOC Updates, Diabetes Care "On Air", DiabetesBio, and The Points of CARE—come together to discuss key highlights and groundbreaking research presented at the 2026 meeting. They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year's findings mean for clinical practice and future research. Available now across all ADA professional podcast channels. Featured Podcasts: DOC Updates – ADA's podcast for primary care Diabetes Care "On Air" – From ADA's clinical research journal, Diabetes Care DiabetesBio – From ADA's flagship research journal, Diabetes The Points of CARE - The official podcast of Diabetes, Obesity, and CardioMetabolic CARE Join the Discussion with: Alice Cheng, MD – Co-host of Diabetes Care "On Air" Kirk Habegger, PhD – Co-host of DiabetesBio Michael Rickels, MD, MS – Co-host of Diabetes Care "On Air" Neil Skolnik, MD – Co-host of DOC Updates and Diabetes Day by Day Kevin Williams, PhD – Co-host of DiabetesBio Richard Beaser, MD – Co-host of The Points of CARE
CardioNerds Dr. Rohit Nathani, Dr. Atefeh Ghorbanzadeh, and Dr. Mariam Riad, discuss Obesity-related Heart Failure with Preserved Ejection Fraction (HFpEF) with Dr. John Ostrominski. This episode was produced as part of the CardioNerds Academy curriculum by House Jones under the guidance of House Chief, Dr. Mariam Riad and Academy Program Director, Dr. Gurleen Kaur. A matching review article will be published in US Cardiology Review, the official journal of CardioNerds. This episode highlights the diverse clinical phenotypes and complex, multifaceted pathophysiology of HFpEF. We take a deep dive into the therapeutic advances that represent paradigm shift in metabolic modulation aimed at improving outcomes in patients with HFpEF and metabolic syndrome. Audio editing by CardioNerds intern Pacey Wetstein. Enjoy this Circulation Paths to Discovery article to learn more about the CardioNerds mission and journey. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscripts here. CardioNerds Heart Success Series PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls HFpEF is a constellation of symptoms often with different underlying pathophenotypes; cardiometabolic type is rising in incidence. Diagnosis is predominantly based on the clinical scenario along with supporting evidence from imaging modalities such as echocardiogram, cardiac MRI, and right heart catheterization. Cardiometabolic HFpEF is a complex syndrome characterized by dysregulated lipid metabolism, systemic inflammation, and hemodynamic abnormalities, all of which contribute to exercise intolerance and frailty. Lifestyle interventions, comorbidities management, and HFpEF therapeutics go hand in hand for comprehensive HFpEF care and offer opportunities for multispecialty collaboration to achieve optimal patient outcomes. References Ostrominski, J, Højbjerg Lassen, M, Butt, J. et al. Adiposity-Related Anthropometrics and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Participant-Level Pooled Analysis of Randomized Clinical Trials. JACC. 2025 Nov, 86 (20) 1760–1777.https://doi.org/10.1016/j.jacc.2025.08.012 Packer, M. The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment. JACC. 2025 Oct, 86 (16) 1269–1373.https://doi.org/10.1016/j.jacc.2025.06.055 Ahmed, N., Dalmasso, C., Turner, M.B. et al. From fat to filter: the effect of adipose tissue-derived signals on kidney function. Nat Rev Nephrol 21, 417–434 (2025). https://doi.org/10.1038/s41581-025-00950-5 Alicic, R.Z., Neumiller, J.J. & Tuttle, K.R. GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease. Nat Rev Nephrol 22, 265–282 (2026). https://doi.org/10.1038/s41581-025-01036-y Ostrominski, J, Harrington, J, Claggett, B. et al. Anthropometric Measures, Cardiovascular Outcomes, and Treatment Effects of Finerenone in Cardiovascular-Kidney-Metabolic Disease: Pooled Participant-Level Analysis of 3 Global Trials. JACC. 2025 Nov, 86 (20) 1781–1801.https://doi.org/10.1016/j.jacc.2025.08.039
Suboptimal sleep quality and quantity are associated with higher body mass index and more difficulty losing weight. In this podcast, JAMA Insights author Atul Malhotra, MD, from the University of California, San Diego, discusses evidence regarding sleep and obesity with JAMA Deputy Editor Mary McDermott, MD. Related Content: Sleep Health and Obesity
Naturopathic gastroenterologist Mark Davis, ND (FABNG), discusses his work in fecal microbiota transplantation (FMT), research, and integrative approaches to GI disease. Davis explains FMT history, screening criteria, delivery methods, how it differs from probiotics, and why it is highly effective for recurrent C. difficile (about a 90% durable cure), while noting FDA-approved products (Rebyota, Vowst) and off-label applications. He describes IRB-approved studies on naturopathic care for IBS and ulcerative colitis and a blinded project comparing consistency across 15–20 stool microbiome labs. The conversation covers evidence for diet in IBS/IBD (including SCD and a semi-vegetarian diet), low-FODMAP as a temporary tool, breath testing and relapse in SIBO, helminthic therapy options and legality, targeted probiotics (Saccharomyces boulardii, Akkermansia, soil-based species), enema therapies, indigo naturalis benefits and risks, saffron evidence for mood, telemedicine practice, and a crowdfunding platform for clinical trials.
The clips of Jillian Michaels going head-to-head with body positivity advocates has been all over social media, and Sara and Caleigh finally sat down to watch the whole thing. The setup: a moderator reads a claim, and whoever gets to the hot seat first gets to argue it with Jillian face to face. First claim up: obesity is not healthy, and pretending it is puts lives at risk.One woman used her turn to object to the word "obese" before ever addressing whether it was true. Another argued that exercise hurt her and dieting didn't make sense to her, without ever explaining how any of that made carrying excess body fat healthy. Jillian didn't blink: fat doesn't just sit on the outside, it wraps around your organs and works against you from the inside too.The real conversation isn't about semantics. It's about what happens when an entire movement convinces people that struggling to lose weight and struggling because you're overweight are the same problem. They're not, and pretending otherwise doesn't make either one easier.Connect with us on social media!Instagram | TikTok | Threads | Youtube | Facebook | X (Twitter) | WebsiteThis podcast offers health, fitness, and nutritional information and is designed for educational and entertainment purposes only. You should not rely on this information as a substitute for, nor does it replace professional medical advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other healthcare professional. Do not disregard, avoid, or delay obtaining medical or health-related advice from your healthcare professional because of something you may have heard on this podcast. The use of any information provided by Nacho Fitness Coach podcast is solely at your own risk.
What happens inside skeletal muscle during obesity—and how can we protect lean mass while losing fat? The PSMF Library is officially live
Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)Have You Ever Wondered If Your Telehealth Weight Loss Clinic Is Actually Giving You Real Medical Care, or Just a Prescription?This episode dives into a JAMA study that's been generating serious buzz throughout the obesity medicine community, and once you hear what it uncovered, you'll understand exactly why. Researchers conducted a "secret shopper" investigation, sending someone posing as a patient to 49 different telehealth clinics offering obesity management medications, simply to see what kind of care they'd actually receive. The findings shed light on where the gaps really are in this rapidly expanding area of healthcare, and they back up what a lot of obesity medicine providers have suspected for quite some time.We're unpacking what comprehensive obesity care is truly supposed to look like, and how you can figure out whether the care you're getting, or the care you're offering, actually holds up. And there are two calls to action woven throughout: if you're someone taking these medications or considering starting them, we'll walk through how to find a provider who's doing this the right way. And if you're a clinician providing this kind of care already, consider this your reminder to put yourself out there more, because there are patients who genuinely need access to someone doing it well.Topics Discussed:The JAMA Study Raising Questions About Obesity TelehealthThe Missing Piece in Many Telehealth Weight Loss ProgramsConvenience Shouldn't Replace Comprehensive Medical CareThe Importance of Clinical Oversight in Telehealth PrescribingWhat Comprehensive Obesity Care Should Look LikeWhere to Start If You're Considering Weight-Loss MedicationHow to Find High-Quality Obesity CareThis episode covers a lot of ground, from the specific numbers behind the study to what a truly thorough evaluation should include, and what red flags to watch for if you're navigating this kind of care yourself. Whether you're a patient trying to figure out if your provider is doing right by you, or a clinician who wants to understand where the industry is falling short, this conversation breaks it all down in a way that's genuinely worth your time. Press play to catch the full episode and get every detail we covered.Want to see the data for yourself? You can check out the full JAMA study here: https://www.sciencedirect.com/science/article/pii/S2667368123000165Connect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com
80% of Americans are metabolically unhealthy, which means the obesity conversation isn't about weight for a lot of people... It's about internal health markers that indicate a declining state of metabolic function regardless of what someone weighs. Inside today's episode, I get into the harder version of the obesity conversation including whether it should be classified as a chronic medical condition, what happens when we label people as broken and then sell them the solution to their "brokenness", and where the personal responsibility conversation sits in a landscape flooded with GLP-1 medications and food environments engineered to defeat every mechanism the body has for satiety.Topics discussed: - The 80% Metabolically Unhealthy Statistic- Obesity as a Chronic Medical Condition- The Broken Mindset Trap- Personal Responsibility and Empowerment- Cardiovascular Risk, Longevity, and Children- Practices, Perceptions, and Physiology- Generational Parenting and Food Culture- The Chronic Dieting Flip Side---------- My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization www.metabolismschool.com---------- [Free] Metabolism School 101: The Video Serieshttp://www.metabolismschool.com/metabolism-101----------Subscribe to My Youtube Channel: https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1----------Grab a Copy of My New Book - Metabolism Made Simple---------- Stay Connected: Instagram: @sammillerscienceYoutube: SamMillerScience Facebook: The Nutrition Coaching Collaborative CommunityTikTok: @sammillerscience----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at operations@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."
CardioNerds (Drs. Apoorva Gangavelli, Jenna Skowronski, and Hannah Every) discuss the continuum of prevention and heart failure with Drs. Anu Lala and Martha Gulati. Grounded in a clinical case of a 55-year-old woman with uncontrolled hypertension, type 2 diabetes, and obesity who is on the trajectory toward heart failure, this episode unpacks a paradigm-shifting framework from a joint HFSA/ASPC Scientific Statement. The discussion explores how prevention should not be siloed from heart failure management but rather integrated across a patient’s lifespan—from primary prevention in at-risk individuals, to secondary prevention in those with established heart failure, to tertiary prevention in patients with advanced therapies such as LVADs and heart transplantation. The experts highlight the importance of aggressive risk factor management, biomarker-guided screening, the AHA’s Life’s Essential 8, and the need for multidisciplinary collaboration and systems-level change to shift heart failure care from reactive to proactive. Audio editing for this episode was performed by CardioNerds Intern, Dr. Julia Marques Fernandes. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Systemic inflammatory diseases are associated with an elevated CVD risk that has significant implications for early detection, risk Heart failure prevention is a continuum, not a checkpoint. Prevention applies at every stage—from at-risk (Stage A) through advanced/post-transplant care—and every clinical encounter is an opportunity to intervene. The AHA’s Life’s Essential 8 (diet, physical activity, nicotine exposure, sleep, BMI, blood lipids, blood glucose, blood pressure) forms the foundation at every stage. Hypertension carries the highest population-attributable risk for heart failure of any modifiable risk factor. In the Framingham Heart Study, 91% of patients with newly diagnosed HF had pre-existing hypertension. The SPRINT trial demonstrated a 38% reduction in HF incidence with intensive blood pressure targets (30 ng/L or NT-proBNP >125 ng/L) identify individuals at heightened risk for progression to symptomatic HF. The ACC/AHA/HFSA guidelines give a Class IIa recommendation for natriuretic peptide screening in at-risk patients. Urine albumin-to-creatinine ratio (UACR) is an underutilized screening tool that provides additional insight into CKM risk. The heart failure label does not close the prevention window—it accentuates it. Secondary prevention through GDMT optimization (quadruple therapy in HFrEF) and continued risk factor management remains critical. Tertiary prevention extends to post-LVAD and post-transplant patients, where hypertension, diabetes, obesity, and CKD management remain essential to long-term outcomes. Show notes For a comprehensive review, please review the full HFSA/ASPC Joint Scientific Statement: Lala A, Beavers C, Blumer V, et al. The Continuum of Prevention and Heart Failure in Cardiovascular Medicine. J Card Fail. 2026;32:75-105. doi:10.1016/j.cardfail.2025.06.013 1. What is the “continuum of prevention” framework, and how does it differ from traditional approaches to heart failure prevention? Historically, prevention and heart failure management have been treated as separate disciplines—primary prevention handled by preventive cardiologists and treatment managed by heart failure specialists. This joint HFSA/ASPC Scientific Statement reframes prevention as a dynamic, continuous process that spans a patient’s entire lifespan, regardless of HF stage or ejection fraction. The framework maps onto the ACC/AHA HF staging system: Primary prevention targets Stage A (“at risk”) and Stage B (“pre-HF”) patients to reduce the burden of incident HF. Secondary prevention targets Stage C (symptomatic) and Stage D (advanced) patients to reduce the impact of established HF through GDMT optimization and ongoing risk factor management. Tertiary prevention encompasses risk factor management in patients with LVADs or heart transplants—populations where hypertension, diabetes, and obesity still drive outcomes. The Central Figure of the statement illustrates that Life’s Essential 8 (blood pressure and lipid control, diabetes management, exercise, sleep, smoking cessation, weight management, and diet/nutrition counseling) forms the foundation at every stage, with pharmacologic and device-based therapies layered on top as disease progresses (Figure) 2. How do traditional risk factors drive heart failure, and what should clinicians prioritize? Hypertension carries the greatest population-attributable risk for HF. In the Framingham Heart Study (N=5,143), HTN was associated with a 2- to 3-fold increased risk of HF, with a population-attributable risk of 39% in men and 59% in women. The SPRINT trial showed a 38% reduction in HF incidence and 25% reduction in the primary composite outcome with intensive BP targets (30 ng/L or NT-proBNP >125 ng/L) are associated with heightened risk for progression to symptomatic HF. In the ARIC study, incorporating NT-proBNP reclassified 20% of older adults without HF into Stage B. Factors that affect interpretation include age, sex, obesity (lower values), and CKD (higher values). High-sensitivity cardiac troponin (hs-cTn): Concentrations above the 99th percentile are now included in the definition of Stage B HF. Troponin testing may complement natriuretic peptides, particularly when BNP/NT-proBNP values are ambiguous. Risk scores: The PCP-HF equation predicts 10-year HF risk using traditional risk factors plus QRS duration. The AHA PREVENT score incorporates HF risk calculation and includes markers of kidney function (albuminuria, eGFR), though it may underestimate risk in men and Black adults. The CKM syndrome staging framework (Stages 0–4) provides a holistic approach to assessing systemic cardiovascular-kidney-metabolic risk. 4. What are the key nontraditional risk factors and cross-cutting themes in heart failure prevention? Genetics: Pathogenic cardiomyopathy variants exist in ~1 in 200 individuals in the general population. The HFSA and ACMG recommend cascade testing to identify at-risk family members. Polygenic risk scores for dilated cardiomyopathy show a 3.8-fold risk for DCM in the top 10th percentile compared with the median. Sex-specific considerations: Women have 2.8 times the odds of developing HFpEF, while men have similarly increased odds of HFrEF. A complete obstetric/gynecologic history is essential—preeclampsia is associated with a 4-fold increased risk of HF. Peripartum cardiomyopathy requires intentional screening in high-risk populations. Cardiotoxic exposures: Clinicians should be aware of medications that cause direct myocardial toxicity (e.g., anthracyclines, trastuzumab, tyrosine kinase inhibitors). A team-based approach with pharmacists can help optimize medication selection and risk factor modification. Social determinants of health: Environmental exposures (air pollution, arsenic, lead, cadmium), food insecurity, financial instability, and limited healthcare access contribute to HF risk and progression. Equity-focused, risk-based prevention strategies are needed. Psychological health: Depression is common in HF and independently associated with worse outcomes. Screening with brief questionnaires (e.g., PHQ-2) is recommended. Meditation, spirituality, and holistic wellness approaches remain underutilized. 5. What systems-level and policy changes are needed to move the needle on heart failure prevention? Multidisciplinary HF prevention clinics that bring together preventive cardiologists, HF specialists, endocrinologists, nephrologists, dietitians, pharmacists, exercise physiologists, and genetic counselors are advocated by the statement. EHR-embedded risk stratification could proactively flag patients on a trajectory toward HF—analogous to sepsis alerts or fall risk flags—enabling earlier intervention, particularly for patients who may not reach a cardiologist. Cardiac rehabilitation remains underutilized, particularly in HFrEF (Class 2b recommendation) and HFpEF (not yet covered by Medicare). The HF-ACTION trial showed quality-of-life benefits, and the REHAB-HF trial showed particular benefit in older patients with HFpEF. Policy priorities include expanding insurance coverage for preventive screening and novel therapies (SGLT2i, GLP-1 RAs, nsMRAs), reducing clinical inertia through team-based care models with closer follow-up intervals, and ensuring equitable access to evidence-based therapies across diverse populations. Digital health and AI hold promise for personalized risk prediction, remote monitoring (e.g., wearable devices, implantable PA pressure monitors), and virtual cardiac rehabilitation to overcome access barriers. Figure Lala A, Beavers C, Blumer V, et al. The continuum of prevention and heart failure in cardiovascular medicine: a joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology. J Card Fail. 2026;32(1):75-105. doi:10.1016/j.cardfail.2025.06.013) References Key references are bolded. Lala A, Beavers C, Blumer V, et al. The continuum of prevention and heart failure in cardiovascular medicine: a joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology. 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Cardiac rehabilitation for patients with heart failure: JACC expert panel. J Am Coll Cardiol. 2021;77(11):1454-1469. doi:10.1016/j.jacc.2021.01.030 Packer M. Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity. Circulation. 2018;137(15):1614-1631. doi:10.1161/CIRCULATIONAHA.117.032474 Lala A, Tayal U, Hamo CE, et al. Sex differences in heart failure. J Card Fail. 2022;28(3):477-498. doi:10.1016/j.cardfail.2021.10.006 Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure. Eur J Heart Fail. 2021;23(3):352-380. doi:10.1002/ejhf.2115 Hershberger RE, Givertz MM, Ho CY, et al. Genetic evaluation of cardiomyopathy—a Heart Failure Society of America practice guideline. J Card Fail. 2018;24(5):281-302. doi:10.1016/j.cardfail.2018.03.004 Levine GN, Cohen BE, Commodore-Mensah Y, et al. 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¿Has escuchado maravillas sobre medicamentos como Ozempic, Wegovy o Mounjaro, pero nadie te habla de las constantes náuseas y el malestar estomacal? La realidad clínica es que una gran parte de los pacientes abandonan estos tratamientos para la obesidad simplemente porque los efectos secundarios arruinan su calidad de vida. Pero la ciencia médica está a punto de dar un salto monumental. En este episodio, descubriremos a la AMILINA, una hormona producida por tu páncreas que está demostrando resultados asombrosos en ensayos clínicos: pérdida de peso significativa sin los severos vómitos ni malestares intestinales de los fármacos actuales. En este episodio aprenderás: → Cómo tu páncreas libera dos hormonas cada vez que comes. → Cómo la amilina bloquea el freno metabólico que hace que recuperes el peso perdido. → Cómo dos equipos de investigadores resolvieron el mismo problema químico de formas distintas. → Cómo la combinación CagriSema alcanza una reducción significativa del peso corporal. → Por qué la amilina resensibiliza tu cerebro a la leptina, algo que la semaglutida no logra. Mi nombre es Dr. Mauricio González, médico internista y especialista en endocrinología en formación. Aquí comparto información basada en evidencia para que tomes decisiones de salud sin mitos ni marketing engañoso. Suscríbete a mi boletín informativo en: www.drmauriciogonzalez.com/ ⚠️ Este podcast tiene fines exclusivamente educativos e informativos y no constituye asesoramiento médico, diagnóstico ni tratamiento personalizado. Los medicamentos que se discuten en este episodio se encuentran en fase de investigación y no cuentan con aprobación de la FDA. Consulta siempre a tu médico o a un profesional de la salud calificado antes de cambiar tu régimen de tratamiento. ¡Sigamos la conversación en redes sociales! Instagram
Send us Fan MailAaron and Peaches sit down to talk Blue Angels flyovers, testosterone testing, military medicine, height-to-waist standards, and why the military has to get serious about health before people break.The episode starts with the Blue Angels beach flyover debate and whether something can be technically questionable while still being completely awesome. Then the guys get into the bigger conversation around the Department of War pushing testosterone checks for men over 30, why the military medical system has resisted basic hormone testing for years, and how operator syndrome, traumatic brain injuries, cortisol dysfunction, vitamin D deficiency, and low free testosterone can wreck performance and mental health.Aaron talks through his own fight to get blood work done, what the military missed, and why private-sector care finally helped him understand the difference between total testosterone and free testosterone.The conversation also hits height-to-waist standards, fat bodies in uniform, why some people will get flagged unfairly, and why most people need to stop making excuses. The bottom line: fitness is not just about looking good in uniform. It affects mental health, cognitive performance, readiness, durability, and who you become after the military.Check out Tasty Gains:TastyGains.comRegister for Operator Training Summit:OperatorTrainingSummit.comChapters:00:00 - Intro, Tasty Gains, and Operator Training Summit03:02 - Blue Angels Flyover Controversy03:39 - Unsafe vs. Inappropriate05:00 - Why Professionals Change the Risk Equation06:59 - Was the Flyover Necessary?08:22 - Pensacola, Nellis, and Airshow Culture09:20 - Testosterone Testing in the Military10:37 - What the Headlines Are Missing11:14 - Operator Syndrome and Low Testosterone12:11 - Fighting the Military Medical System12:55 - Vitamin D Deficiency in the Military14:34 - The Problem With “Normal” Testosterone Ranges16:00 - Trying to Raise Testosterone Naturally17:14 - Total Testosterone vs. Free Testosterone18:08 - TBI, Free Test, and Feeling Broken18:57 - Whoop Blood Work and Better Data19:19 - Breaking Down Institutional Resistance20:12 - Why This Could Lead to Better Screening21:02 - How the Referral System Fails People22:08 - Why Baseline Testing Matters22:34 - Trauma Medicine vs. Clinical Medicine23:55 - Military Medicine, COVID, and Bad Advice26:35 - Readiness Pressure and Medical Liability27:30 - SSRIs, Mental Health, and Missed Questions29:26 - The Military Health System Problem30:33 - Women, Hormones, and HRT30:42 - What to Ask Before Accepting Medication31:29 - Akron Bar Fight Story34:46 - Air Force Height-to-Waist Ratio35:11 - Body Composition Standards Come Back Around36:52 - Old BMI Standards and Fat Boy Programs37:19 - Height and Weight Charts39:41 - Peaches Tests the Calculator41:16 - When the Standard Misses Body Type42:40 - Trent's Monster Habit43:29 - Strategic Energy Drinks43:56 - Ten-Year-Old Crushes the Army PT Test45:30 - Kids, Discipline, and Internet Boundaries47:34 - Coaching Kids Through Hard Things48:25 - Wrestling Coach Motivation50:38 - Height-to-Waist and Job Performance51:40 - Human Performance and Mental Health52:34 - Obesity, COVID, and Comorbidities53:54 - Water, Sunlight, Nutrition, and Fitness55:26 - What People Cut First When Life Gets Busy55:42 - Sleep as a Performance Enhancer56:43 - Why Fitness Improves Mental Health58:26 - Confidence, Attraction, and Looking Better59:45 - Extrinsic Motivation Still Counts01:01:12 - Final Thoughts and Members-Only PreviewSupport the showJoin this channel to get access to perks: HEREBuzzsprout Subscription page: HERERegister for our Operator Training Summit: OperatorTrainingSummit.comFind an Air Force Recruiter: AirForce.comCollabs:Ones Ready - OnesReady.com 18A Fitness - Promo Code: ONESREADY ATACLete - Follow the URL (no promo code): ATACLeteDanger Close Apparel - Promo Code: ONESREADYDFND Apparel...
Do you have trouble sleeping? An occasional late night or early morning is probably not dangerous, but too many people get too little sleep on a regular basis. How does that affect their health? Even more importantly, what can they do to change the situation? You'll want to listen to find out if you need a sleep reset. At The People's Pharmacy, we strive to bring you up to date, rigorously researched insights and conversations about health, medicine, wellness and health policies and health systems. While these conversations intend to offer insight and perspective, the content is provided solely for informational and educational purposes. Please consult your healthcare provider before making any changes to your medical care or treatment. How You Can Listen You could listen through your local public radio station or get the live stream at 7 am EST on Saturday, July 18, 2026, through your computer or smart phone (wunc.org). Here is a link so you can find which stations carry our broadcast. If you can't listen to the broadcast, you may wish to hear the podcast later. You can subscribe through your favorite podcast provider, download the mp3 using the link at the bottom of the page, or listen to the stream on this post starting on July 20, 2026. The podcast will be available on Monday (July 20, 2026) Do You Need a Sleep Reset? Why is sleep so important for good health? Our guest is a sleep medicine specialist who uses a metaphor of Disneyland. Crucial maintenance on the theme park happens at night, when there are no visitors. Streets are cleaned, flower beds are weeded, and rides are inspected and, if needed, repaired. None of that can happen while the park is open for business. Our bodies and brains also need time for maintenance and repair, and some of that happens while we are sleeping. When we don't get the rest we need, we may find ourselves at increased risk for diabetes, cardiovascular problems, cancer, cognitive challenges and even premature death. Unfortunately, anxiety about not sleeping can keep people awake all on its own. How can people break that cycle? We'll also discuss ways that people can get help avoiding screens at night. That is an important part of a sleep reset. Blue light from the screen signals the brain to be alert instead of relax. Scrolling social media can often be emotionally upsetting, which also makes it more difficult to fall asleep. Is Your Diet Keeping You Awake? Most of us recognize that a big midnight snack, á la Dagwood Bumstead of the Blondie comic, is probably not conducive to sleeping well. How does nighttime eating affect our circadian rhythm? Are there diets that we should avoid because of their impact on sleep? Dr. Seheult describes a study in which volunteers had their sleep stages monitored closely during the time they were consuming different diets (Obesity, July 2023). When they followed a high-fat, high-sugar diet, it disturbed the pattern of their brain waves during what should have been restorative sleep. How Do Sleep Problems Affect Eating Habits? A lot of us are aware that when we are sleep deprived, we are more inclined to become hangry and we may be less discerning about what we eat. A recent study shows that the sleep deprivation can have an effect even if it is fairly mild and short-term. Scientists recruited people who normally sleep seven to eight hours a night and asked them to stay up an extra hour and a half (Annals of Internal Medicine, July 7, 2026). During the six weeks of that part of the experiment, people were less active during the day. They also ate more, so they gained about a pound, on average, during those six weeks. Presumably, disrupting sleep for a longer period of time would result in greater weight gain and metabolic disruption. Would a Ketogenic Diet Help with a Sleep Reset? A ketogenic diet, in which the body relies on ketones rather than glucose for energy production, may be helpful. In particular, fasting overnight for at least 14 hours helps the body do what it must during sleep time. To figure out when you should stop eating, identify when you usually start to feel sleepy. That should be your bedtime. Having your last meal of the day about three hours before that will generally offer enough time for digestion so that you don't experience reflux in the middle of the night. Morning Light and Afternoon Naps Your sleep reset may depend on getting your own circadian rhythm to synchronize with the rest of the world. That is where early exposure to morning light comes in. It's beginning to feel a bit like The People's Pharmacy is on repeat: get morning light exposure! It sets your system up for feeling awake and alert during the day and starting to feel sleepy as the light fades in the evening. Obviously, this is most helpful for people who work during daylight hours. Those working overnight shifts would have to organize their days differently. People who have trouble falling asleep may be tempted to take a nap in the afternoon to make up for the lost sleep. That could be a mistake, as it relieves the sleep pressure that helps people fall asleep without trying. Learning to Fall Asleep If you interact with parents of very young children, you may have heard of sleep training. People have strong feelings about this, both pro and con. Adults rarely need sleep training, though. What we are more likely to need is “not-sleeping un-training.” Too many people approach the bedroom as though it were a stage, and sleep is the performance. No wonder they may develop some performance anxiety about sleeping! Other individuals have learned to associate the bedroom with tossing, turning and watching the clock. Consequently, their bodies tense up instead of relaxing when they get between the sheets. There is no easy quick fix for this problem, but cognitive behavior therapy for insomnia has been proven effective for most people. How About PM Pain Relievers? Even though there isn't an easy fix for sleep troubles, many people want one. They reach for the PM pain reliever and hope it will offer them a good night's sleep without a prescription. The “PM” part of that pain reliever is an old-fashioned antihistamine called diphenhydramine. You might be more familiar with its brand name: Benadryl. You'll also find it in Tylenol PM, Advil PM and all the other PM meds because it tends to make people feel drowsy. What's wrong with that? To start with, it isn't clear that it remains effective after a week or two. In addition, people with restless leg syndrome often find that it makes their condition worse. Other folks report that diphenhydramine can result in an unpleasant “hangover” the next day, in which they feel drowsy though not asleep for a good part of their waking hours. What Wakes You Up at Night? If your sleep problem is waking in the wee hours and having trouble getting back to sleep, you should consider the possibility that you have sleep apnea. The REM sleep of those early morning hours is not as deep as some other sleep stages. Consequently, an alarm signal from your brain saying you haven't taken a breath for 20 or 30 seconds may be more likely to wake you. Sleep apnea may be treated by providing air so that the pressure props the collapsing airway open. We discuss this in greater detail along with a new alternative to a CPAP machine in the podcast for this week. This Week’s Guest Dr. Roger Seheult is an Associate Clinical Professor at the University of California, Riverside School of Medicine. He is also an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple board-certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine, and Sleep Medicine through the American Board of Internal Medicine. His current practice is in Beaumont, California. He is a critical care physician, pulmonologist, and sleep physician at Optum California. Dr. Seheult lectures routinely across the country at conferences and for medical, PA, and RT societies. He is the director of a sleep lab and the Medical Director for the Crafton Hills College Respiratory Care Program. He is co-founder and presenter for MedCram.com, a site that offers concise and easy-to-follow medical videos on a range of topics. Roger Seheult, MD, MedCram, Loma Linda, UC-Riverside Listen to the Podcast The podcast of this program will be available Monday, July 20, 2026, after broadcast on July 18. You can stream the show from this site and download the podcast for free. Download the mp3, or listen to the podcast on Apple Podcasts or Spotify.