Podcasts about FXS

FXs' Shogun continues. As Toranaga returns to new challenges, Mariko and Blackthorne welcome a surprise guest.

DeFi Dave is the CoFounder/Cohost of Flywheel DeFi and Core Advocate at Frax Finance. In this episode, we provide a timely guide to Frax Finance's new L2 called Fraxtal. Fraxtal has an upcoming FXTL points airdrop to FXS stakers based on a March 6th snapshot, as well as a continuing weekly program starting March 13th to award stakers, DeFi users, and dApp developers on Fraxtal. Get caught up on the vision behind one of the promising Ethereum L2s, built by the reputable team and community behind Frax stablecoins and Frax DeFi apps. ------

Today, Corval is joined by DeFi Dave of Flywheel DeFi to talk about Frax Finance's latest developments with Fraxtal: Fraxtal is a modular blockchain with a “fractal scaling” roadmap & unique blockspace incentives. All incentive systems, liquidity rewards, and new $FXTL points, & the airdrop snapshot will start later this month to give launch partners & teams time to deploy their dapps & stake $FXS. Thread on Fraxtal: https://x.com/fraxfinance/status/1755... DeFi Dave on X: https://x.com/DeFiDave22?s=20 Flywheel DeFi on X: https://x.com/FlywheelDeFi?s=20 --- The Absolute Best Crypto Research Platform: https://revelointel.com/ --- Blockbytes Community Discord:   / discord   --- The Ecosystem You Need To Keep Your Eyes On: https://www.oath.eco/ --- Nothing you read/see on Blockbytes YouTube or blockbytes.com should be considered financial advice. Please use all of the information available to you and do your own research. There are many risks inherent with Crypto currency investing which includes up to complete loss of funds. So please never invest with money you cannot afford to lose. All of blockbytes content is for entertainment purposes only and the opinions of the presenters and guests do not necessarily reflect the views of Blockbytes LLC. Nothing you see in any of the blockbytes content should be considered a solicitation to buy or sell any assets. Any links of which Blockbytes receives a commission will be clearly marked as such. If you like the content that we produce and can use the products then please consider using our referral links above

Cryptovestor is an anonymous DeFi investor. In this episode, we speak with an anonymous DeFi investor, to uncover the latest DeFi alpha on a family of protocols related to Curve, including Convex Finance, Frax Finance, Prisma Finance, and f(x) Protocol. This episode is ideal for advanced users and investors looking for their own edge while using these growing veTokenomics protocols. ------

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.01.551430v1?rss=1 Authors: Giua, G., Lassalle, O., Chavis, P., Manzoni, O. J. Abstract: Fragile X syndrome (FXS), a neurodevelopmental disorder caused by the inactivation of the FMR1 gene, is one of the most common causes of autism spectrum disorder (ASD). People with FXS and ASD often have difficulty regulating their emotions and behaving in a socially appropriate way. The specific neuronal circuits and synaptic dysfunctions involved in social deficits in FXS are not yet fully understood. The basolateral amygdala to accumbens pathway is central to normal social behavior, and we investigated the functionality of this pathway in a novel mouse model of FXS (Fmr1/y::Drd1a-tdTomato). We used optogenetics to distinguish synapses between BLA neurons and spiny projection neurons in the NAcC. We found that the BLA-NAcC connection in FXS mice displayed heightened synaptic strength along with specific alterations in synaptic plasticity. In FXS, enhanced AMPA and NMDA postsynaptic currents elevated BLA-D2 SPN synaptic strength, while BLA-D1 SPNs increased firing probability occurred without altered transmission. This results in an overall increase in postsynaptic integration in both D1 and D2 SPN BLA-NAcC pathways compared to WT littermates. Further, the absence of FMRP leads to a specific deficit in long-term depression for BLA-D1 SPNs connections. The neurobiological changes identified in this study may underlie the susceptibility to stressors, socio-communicative difficulties, and altered reward-related processes that are characteristic of FXS pathology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.14.549070v1?rss=1 Authors: Martinez, J. D., Wilson, L. G., Brancaleone, W., Peterson, K., Popke, D. S., Caicedo Garzon, V., Perez Tremble, R., Donnelly, M. J., Mendez Ortega, S., Torres, D., Shaver, J., Clawson, B. C., Jiang, S., Yang, Z., Aton, S. Abstract: Fragile X syndrome (FXS) is a highly-prevalent genetic cause of intellectual disability, associated with disrupted cognition and sleep abnormalities. Sleep loss itself negatively impacts cognitive function, yet the contribution of sleep loss to impaired cognition in FXS is vastly understudied. One untested possibility is that disrupted cognition in FXS is exacerbated by abnormal sleep. We hypothesized that restoration of sleep-dependent mechanisms could improve functions such as memory consolidation in FXS. We examined whether administration of ML297, a hypnotic drug acting on G-protein-activated inward-rectifying potassium channels, could restore sleep phenotypes and improve disrupted memory consolidation in Fmr1-/y mice. Using 24-h polysomnographic recordings, we found that Fmr1-/y mice exhibit reduced non-rapid eye movement (NREM) sleep and fragmented NREM sleep architecture, alterations in NREM EEG spectral power (including reductions in sleep spindles), and reduced EEG coherence between cortical areas. These alterations were reversed in the hours following ML297 administration. Hypnotic treatment following contextual fear or spatial learning also ameliorated disrupted memory consolidation in Fmr1-/y mice. Hippocampal activation patterns during memory recall was altered in Fmr1-/y mice, reflecting an altered balance of activity among principal neurons vs. parvalbumin-expressing (PV+) interneurons. This phenotype was partially reversed by post-learning ML297 administration. These studies suggest that sleep disruption could have a major impact on neurophysiological and behavioral phenotypes in FXS, and that hypnotic therapy may significantly improve disrupted cognition in this disorder. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Wir haben über News aus dem Bitcoin und Ethereum Ecosystem geredet. Es gab eine Analyse zu FXS und dem ERC 6551 und viele andere Dinge.

Ouroboros shares with us what it's like from being an equity investor to DeFi fund manager, his unbridled conviction in $FXS, and what's to come in his Frax thesis report.Check out Ouroboros on Twitter

Each month, our Carrier Connections program features a different X-linked condition with the goal to increase awareness and education of X-linked conditions and how they impact females. This month, we are featuring Fragile X syndrome. Fragile X syndrome is a heritable X-linked disorder caused by an abnormality in the FMR1 gene. This gene makes the protein, FMRP, which plays a critical role in the development of nerve cells and the production of other cellular proteins. An issue in this FMR1 gene causes an absence or severe deficiency of the FMRP protein, resulting in a range of developmental problems and distinctive physical features. It typically results from a specific mutation, or alteration of DNA, that causes a CGG base repeat to occur over 200 times in the damaged FMR1 gene. Molecular genetic testing can be used to diagnose this condition by identifying the 200 CGG repeats in the FMR1 gene. Women with a fragile X premutation, or 55 to 200 repeats of the FMR1 gene, have an increased risk of having a child with fragile X syndrome.  Additionally, female fragile X premutation carriers may experience menstrual and menopausal abnormalities, infertility, diminished ovarian reserve, and chronic hypoestrogenism. Such chronic hypoestrogenism has been associated with impaired bone health and an increased risk of cardiovascular disease. Furthermore, female carriers of a fragile X premutation have been found to have neuropsychiatric issues including neuropathy, increased anxiety and depression, and tremor/ataxia syndrome. Some studies have also associated thyroid abnormalities and hypertension to fragile X syndrome in women.  Today, we are joined by Rebecca Kronk, PhD, MSN, CRNP, ANEF, FAAN, CNE. Dr. Rebecca Kronk joined Duquesne University School of Nursing as an Assistant Professor in August 2010, earned tenure in 2016 and was promoted to Full Professor in 2022. She is a board certified pediatric nurse practitioner. Dr. Kronk earned her MSN from the University of Pittsburgh School of Nursing and a PhD in Applied Development Psychology at the University of Pittsburgh, School of Education. Dr. Kronk was a fellow in the Maternal and Child Health Training program providing leadership and education in neurodevelopmental disabilities and autism (LEND) at the University of Pittsburgh. Dr. Kronk has been in the field of pediatric nursing for over 40 years and she is experienced in helping children and families with a range of developmental issues. She has enjoyed combining clinical work with teaching and research. The theoretical framework of her research has been based on the International Classification of Functioning, Disability, and Health published by the World Health Organization. Dr. Kronk has conducted several research studies on the sleep patterns of children with Fragile X syndrome and developmental functioning of children in the FXS gray zone alleles. Her ongoing research has focused on undergraduate educational interventions to promote learning in genetics and caring for people with disabilities. Carrier Connections is sponsored by Horizon Therapeutics, Sanofi, and Ultragenyx Pharmaceutical. For more information about our organization, check out rememberthegirls.org. National Fragile X Foundation Registry

Erst werden alle verklagt, dann machen alle Crypto Verwahrung und Starten ETFs.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.24.538123v1?rss=1 Authors: Hooshmandi, M., Sharma, V., Perez, C. T., Sood, R., Simbriger, K., Wong, C., Lister, K. C., Guzman, A. U., Bartley, T. D., Rocha, C., Maussion, G., Nadler, E., Roque, P. M., Gantois, I., Popic, J., Levesque, M., Kaufman, R. J., Avoli, M., Sanz, E., Nader, K., Hagerman, R. J., Durcan, T. M., Costa-Mattioli, M., Lacaille, J.-C., Martinez-Cerdeno, V., Gibson, J. R., Huber, K., Sonenberg, N., Gkogkas, C. G., Khoutorsky, A. Abstract: Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum disorder (ASD). However, the role of a major pathway controlling protein synthesis, the integrated stress response (ISR), in ASD remains poorly understood. Here, we demonstrate that the main arm of the ISR, eIF2 phosphorylation (p-eIF2), is suppressed in excitatory but not inhibitory neurons in a mouse model of fragile X syndrome (FXS; Fmr1-/y). We further show that the decrease in p-eIF2 is mediated via activation of the mTORC1. Genetic reduction of p-eIF2 only in excitatory neurons is sufficient to increase general protein synthesis and cause autism-like behavior. In Fmr1-/y mice, genetic restoration of p-eIF2 solely in excitatory neurons reverses elevated protein synthesis and rescues autism-related phenotypes. Thus, we reveal a previously unknown causal relationship between excitatory neuron-specific translational control via the ISR pathway, general protein synthesis and core phenotypes reminiscent of autism in a mouse model of FXS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.10.536251v1?rss=1 Authors: Kuruppath, P., Xue, L., Pouille, F., Jones, S. T., Schoppa, N. Abstract: Fragile X syndrome (FXS) is the single most common monogenetic cause of autism spectrum disorders in humans. FXS is caused by loss of expression of the Fragile X mental retardation protein (FMRP), an mRNA-binding protein encoded on the X chromosome involved in suppressing protein translation. Sensory processing deficits have been a major focus of studies of FXS in both humans and rodent models of FXS, but olfactory deficits remain poorly understood. Here we conducted experiments in wild-type and Fmr1 KO (Fmr1-/y) mice (males) that lack expression of the gene encoding FMRP to assess olfactory circuit and behavioral abnormalities. In patch-clamp recordings conducted in slices of the olfactory bulb, output mitral cells (MCs) in Fmr1 KO mice displayed greatly enhanced excitation, as evidenced by a much higher rate of occurrence of spontaneous network-level events known as long-lasting depolarizations (LLDs). The higher probability of LLDs did not appear to reflect changes in inhibitory connections onto MCs but rather enhanced spontaneous excitation of external tufted cells (eTCs) that provide feedforward excitation onto MCs within glomeruli. In addition, in a go/no-go operant discrimination paradigm, we found that Fmr1 KO mice displayed impaired discrimination of odors in difficult tasks that involved odor mixtures but not altered discrimination of monomolecular odors. We suggest that the higher excitability of MCs in Fmr1 KO mice may impair fine odor discrimination by broadening odor tuning curves of MCs and/or altering synchronized oscillations through changes in transient inhibition. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.530447v1?rss=1 Authors: Messaoudi, S., Stoufflet, J., Fouquet, C., Doulazmi, M., Allam, A., Paillard, T., Trembleau, A., Caille, I. Abstract: The Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability, and the first monogenic cause of Autism Spectrum Disorder. FXS is caused by the absence of the RNA-binding protein FMRP (Fragile X Mental Retardation Protein). Neuronal migration is an essential step of brain development allowing displacement of neurons from their germinal niches to their final integration site. The role of FMRP in tangential neuronal migration remains unexplored. We studied the consequences of FMRP absence on tangential migration, using the postnatal Rostral Migratory Stream (RMS) as an experimental system. In Fmr1-null RMS, neurons exhibit a slowed-down migration and an impaired trajectory, associated with defects of their centrosomal movement. Through RNA-interference-induced knock-down of Fmr1, we show that these migratory defects are cell-autonomous. Mutated neurons also display altered morphology as well as defects in their microtubule tyrosination distribution. Finally, we show that the FMRP mRNA target involved in these defects is MAP1B (Microtubule-Associated Protein 1B), whose knock-down rescues most migratory defects. Our results thus unveil a new neurodevelopmental role of FMRP, as a crucial actor of postnatal tangential migration, potentially important for the understanding of FXS pathophysiology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Tras la resaca Omega volvemos a la realidad de hacer el programa sin público. Y no sin estar un poco de bajona nos disponemos a charlar de esas películas que intentan cambiar dramáticamente el sentido de la narración con un girito al final. Muchas lo intentan, y algunas fracasan... como Renato haciendo FXs caseros. ¿Quieres saber de qué va eso? dale ya al play.

Staking könnte reguliert werden, liquid staking kommt zu FXS und ja, es gibt jetzt Bitcoin NFTs.

Shark, Wagmi and Stablino break down the week that's been.Nothing in the show is financial or any other type of advice.Theme music used under license.Mentioned on the show this week:OHM = Growth Coin!Grail token https://www.coingecko.com/en/coins/camelot-token Silo https://app.silo.finance/silo/0xc413dd03555f3eb29d834b482d386b2999dc2eb0Empire podcast https://youtu.be/ThSPmzIlZ8oDefi Llama launches DLNews https://www.dlnews.com/ - it's great!Berachain - Bong Bears NFT rip upwards 2.2ETH per Bitbear https://opensea.io/collection/berachain-bit-bears - rumors that Berachain launches this month Goblerinos - 1.5ETH floor https://opensea.io/collection/goblinarinos https://twitter.com/KlimaDAO/status/1622480779761836032 Klima https://twitter.com/KlimaDAO/status/1622480779761836032 Nice little bump in our Aura sitting at $510K https://debank.com/profile/0x8caf91a6bb38d55fb530dec0fab535fa78d98fad looks like our $6M in CVX has now been relocked https://debank.com/profile/0x2d643df5de4e9ba063760d475beaa62821c71681 BUT we are still sitting on $200K of unlocked FXS https://debank.com/profile/0xde7b85f52577b113181921a7aa8fc0c22e309475 Council in the discord https://youtu.be/mMKRm-JPZJ0OHM secondary market https://dune.com/spoysp/ohm-bonds-secondary-marketHoney Jar https://twitter.com/0xhoneyjar

In this episode, I speak with Rebecca, who discusses her career working with children, which led her to focusing on treatment and research of children on the autism spectrum. She discussed being influenced by her training in Philadelphia, which had a strong family systems component, and how working with the parents and children is a foundation for her Regulating Together work. She explains that the children are in a group where they learn affect regulation skills, while the parents are in another group, also learning affect regulation skills, how to coach the kids at home, and prevention and behavioral management skills. The skills the children learn are relaxation skills, identifying triggers and physical reactions, rating emotions, problem solving skills, mindfulness, radical acceptance and cognitive flexibility. She discussed how the caregiver training has a lot of focus on preventing the emotional dysregulation, as well as techniques for managing the dysregulation and behavior problems when they do occur. Additionally, the caregivers are encouraged to use the skills in order to regulate themselves, and how this helps with coregulation with their child. Rebecca discussed using CBT with a child with autism and modifications you might make since many autistic children can struggle with rigidity. She also remarked on how the group leaders have the ability to work with the children in vivo, at the end of the group where the kids earn time to play games. The group facilitators help the children implement the skills they learned if they become triggered during that time socializing. We discuss the research and how they found that the biggest gains were realized between five to ten weeks after the regulating together series was over, which highlights that the benefits of affect regulation and that a shift in behavior may take time to appear. We discussed other applications for the model and future potential research directions and a trial starting using a canine assisted version of the model. Rebecca explains that her and her team will be publishing their manual and are currently training clinicians in the use of this model. Rebecca C. Shaffer, PsyD, is a clinical psychologist and currently serves as an Associate Professor of Pediatrics at Cincinnati Children's Hospital with an affiliated appointment at the University of Cincinnati. Rebecca is the director of Psychological Services for the Cincinnati Fragile X Center, where she oversees the assessment and treatment of individuals with fragile X syndrome (FXS). Rebecca and her team have created an emotion dysregulation treatment program for children with ASD called Regulating Together. Regulating Together treats emotion dysregulation, especially with reactivity and irritability, in a group setting with concurrent caregiver training. She currently leads several research studies, as well as publications, focused on the development and efficacy of this program. She also serves as the primary investigator of the Simons Foundation Powering Autism Research (SPARK) study at Cincinnati Children's and other ASD-specific studies. Rebecca has had numerous publications and trains clinicians in Regulating Together throughout the country. To learn more about training in Regulating Together and the research behind it, check out the Shaffer Lab and contact by clicking here.

Primetime on the Big Game, Making of Super Bowl Ads w/ Rich Singer - BRT S04 EP04 (166) 1-22-2023                    What We Learned This Week One Sentence – What does the Client want to tell the customers, in 1 Sentence One Big Idea – One Main Idea, One Emotion, One Story, One Promise, One Call to Action (CTA) David Ogilvy is the Father of Modern Advertising, Ad Man from Madison Ave in NYC, Mad Men is based on his ad firm TV is Expensive. There is a tendency for clients to want to jam in too much into an ad. AD Agency starts working on Super Bowl ads in August of the previous year, it is a 6 month process.     Guest: Rich Singer  https://www.linkedin.com/in/richsinger/   Award-winning Creative Director/Copywriter with over a decade of experience. Brands include Nike, The NFL, ESPN, E*TRADE, Yahoo and GE. Portfolio: zackandrich.com     Notes: Seg. 1 The show madman is about an ad agency in New York City in the 1960s. It is based on the classic ad agency of Madison Avenue called Ogilvy and Mather. It was run by David Ogilvy. Ogilvy is considered the father of modern advertising. He talked about that ads needed One Big Idea. An idea that is unique, timeless and surprising. Ogilvie was a big believer in direct response advertising, bottom line when you sell products. He had many advertising tenants or Commandments. You can't bore people into reading your ad. Don't be cute, be clear. Clearly define the position of the ad, who it is for. Ad should be conversational, clear with no jargon, to not confuse customers. Use the language of the customer. Ad copy should have simple headlines, with short words, short sentences and short paragraphs. Michael Masterson of Agora Publishing took the one big idea and elaborated on it. He said all ad copy should be about One Idea. This makes the ad copy organized, easier to follow, and it flows better. One Idea with one emotion, telling one story, giving the customer one promise, and finally one action for the customer to take.   Clip from 12/2021 Hollywood / Marketing Show Hollywood, Storytelling & Evil Dead's Bruce Campbell Nostalgia in Hollywood Marketing MB on Sales and Storytelling, Mad Men TV Show Business Lessons from Westworld TV Show (on HBO). In the Mad Men (TV Show on AMC) episode from season 1 called ‘The Wheel', Don Draper compares a slide viewer to a carousel, and then a time machine. The slides are taking you back to a better time when everything was good. He talks of the power of nostalgia, and the emotions we carry for the past. The word nostalgia comes from two Greek words; nostos, meaning “to return home,” and algos, meaning “pain.” In modern times, defined as a feeling of pleasure, and also slight sadness when you think about things that happened in the past. When we yearn for the past, we want to re-capture the magic, the old emotion we once felt. Full Show: HERE   Seg 2 Rich Singer has a 20 year career in advertising, working for New York firms. He started in print ads, then radio, billboards, smaller TV ads and worked his way up to doing major TV ads and Super Bowl ads. When you first meet with a client to create an ad campaign what do you discuss? Try to determine what the client wants to say. Boil down the client message to one sentence. The ad needs to be clear. What the client wants to say, needs to be in one sentence. TV is expensive. There is a tendency for clients to want to jam in too much into an ad. They want to have multiple messages, when you need one message that can be laid out in one sentence. What is the objective of the ad? Is it a brand story, building the company brand. Is it an offer story, like a special sales package being run in all the stores. There are different levels to a sales funnel and your advertising has to match what level you believe your customers are on. Customers who are new to a brand, would need to see a different ad from a company that has a well established brand where customers already know what they're getting. The analogy Rich uses when talking with clients, is like a dog with a tennis ball. If you throw one tennis ball at a dog he catches that. If you throw two tennis balls at a dog he just stands there, because he doesn't know what to do. This is what customers feel like if you try to throw too many messages at them in one ad. After the initial meeting with the client the creative team has typically 2 weeks to create a concept. Then you will check in with the client to discuss the overview of the concept, see if it is to the client's liking. Then typically you have 2 more weeks to work it out more. Meeting number 2, creative team would show the client a first draft of a script. Rich is a copywriter and creative who works with his partner who is an art Director. They run a team of six people total, broken into three teams of 2, each also consisting of a copywriter and an art Director.   Seg 3 Super Bowl ads ship to Network about 2 weeks before the big game. The process to create the Super Bowl ads started months before. Networks will approve the ad script, with lawyers also working on that process. Networks have the right to reject an ad from an agency. The last thing you want, and it's rare, is to send an ad for the Super Bowl to a Network and they rejected it. Agencies start working on Super Bowl ads in August of the previous year, and it is about a 6 month process. A client is spending $7 million with the net work to buy a 30 second spot during the Super Bowl. After the initial meeting, the creative team spends 3 to 4 weeks writing the first draft of the spot. In September Rich and his team would present the script or Scripts, could be three to the client. In the presentation will be Rich, his partner, his boss, meeting with the client team which could be 3 to 4 people. Rich and his team has created six Super Bowl ads. Ads are initially filmed in November, or about 2 1/2 months before the Super Bowl. Sometimes, though an ad could be filmed as late as New Year's. Many people plus lawyers review Scripts and there are multiple revisions throughout the process. The final script is put together before filming. Lawyers and clients are looped in throughout the process and approving the script. Once you have approved Scripts you go out and you hire a Director and a production team to make the commercial. The Director would then be responsible to create a treatment and may be a storyboard for the commercial. The ad agency has a producer who works with the production company and Director to get the process going. There's also a line producer who is on site during a commercial shoot keeping the process moving. At an actual commercial shoot there might be a production team that could be upwards of 100 people plus actors and extras who are in the ad. The agency will send 6 to 10 people, as well as the client probably has 3 to 7 people also at the shoot.   Seg 4 After a commercial is filmed goes into post production. This involves editing the commercial, possible re-shoots, and post edits. This is also where computer graphics and digital effects are added to an ad as well as music and sound. Special effects and computer graphics are very advanced where you can change backgrounds within an ad. Amount of special FXs all depends on the budget of the commercial. Rich has been involved in commercials filmed at multiple NFL stadiums where there could be as many as 100 extras to sit in a crowd. Usually when you create a Super Bowl, the agency and client are in agreement on what they're trying to accomplish. The most likely goal is brand buzz. You know you have a successful Super Bowl ad when it's a crowd pleaser, people are entertained, and they are talking about it the next day. The goal of any great Super Bowl ad is to be memorable and entertaining. Again clients are spending a lot of money, $10 million for this process. $7 million with the NFL and Network to air the ad, and a $3 million production cost. You're hiring actors, production teams, possibly celebrities and athletes. There is a lot involved in a 30 second ad. Rich said the script needs to be extremely tight. A 30 second ad would have 30 frames in it and every frame Hass to be thought out & timed, and accounted for in the script.     BRT Sales / Marketing: https://brt-show.libsyn.com/category/Sales-Marketing-Networking-HR   BRT Hollywood: HERE   BRT Business: HERE     Investing Topic: https://brt-show.libsyn.com/category/investing More - BRT Best of: https://brt-show.libsyn.com/category/Best+Of     Thanks for Listening. Please Subscribe to the BRT Podcast.    Business Roundtable with Matt Battaglia The show where Entrepreneurs, High Level Executives, Business Owners, and Investors come to share insight and ideas about the future of business. BRT 2.0 looks at the new trends in business, and how classic industries are evolving.  Common Topics Discussed: Business, Entrepreneurship, Investing, Stocks, Cannabis, Tech, Blockchain / Crypto, Real Estate, Legal, Sales, Charity, and more…  BRT Podcast Home Page: https://brt-show.libsyn.com/ ‘Best Of' BRT Podcast: Click Here BRT Podcast on Google: Click Here BRT Podcast on Spotify: Click Here                    More Info: https://www.economicknight.com/podcast-brt-home/ KFNX Info: https://1100kfnx.com/weekend-featured-shows/   Disclaimer: The views and opinions expressed in this program are those of the Hosts, Guests and Speakers, and do not necessarily reflect the views or positions of any entities they represent (or affiliates, members, managers, employees or partners), or any Station, Podcast Platform, Website or Social Media that this show may air on. All information provided is for educational and entertainment purposes. Nothing said on this program should be considered advice or recommendations in: business, legal, real estate, crypto, tax accounting, investment, etc. Always seek the advice of a professional in all business ventures, including but not limited to: investments, tax, loans, legal, accounting, real estate, crypto, contracts, sales, marketing, other business arrangements, etc.  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.03.522654v1?rss=1 Authors: Rahmatullah, N., Schmitt, L., DeStefano, L., Post, S., Chaudhari, G., Robledo, J., Pedapati, E., Erickson, C., Portera-Cailliau, C., Goel, A. Abstract: Attention deficit is one of the most prominent and disabling symptoms in Fragile X Syndrome (FXS). Hypersensitivity to sensory stimuli contributes to attention difficulties by overwhelming and/or distracting affected individuals, which disrupts activities of daily living at home and learning at school. We find that auditory or visual distractors selectively impair visual discrimination performance in both humans and mice with FXS, but not their typically developing controls. Vasoactive intestinal polypeptide (VIP) neurons were significantly modulated by incorrect responses in the post-stimulus period during early distractor trials in WT mice, consistent with their known role as error signals. Strikingly, however, VIP cells from Fmr1-/- mice showed little modulation in error trials, and this correlated with their poor performance on the distractor task. Thus, VIP interneurons and their reduced modulatory influence on pyramidal cells, could be a potential therapeutic target for attentional difficulties in FXS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Recently announced Ribbon integration with Google SIP Link provides significant enhancement to Google VoIP Services. Ribbon SBCs have been certified to work with Google SIP link. Gordan Eddy discusses the enhancements to Google SIP Link with Don Witt of The Channel Daily News, a TR publication. Gordan Eddy In addition to selecting their own telecom provider they are provided security, legacy connectivity for analog TDM lines, migration support from old PBX systems and continued support for those PBX systems that need to stay connected. Resiliency and failover are also provided. For channel partners, this provides a new combined offering that opens up additional sales opportunities for the Ribbon Channel. Listen in to learn more about the channel details. Google SIP Link requires a Google-certified SBC to act as a bridge between Google Voice and an organization's telecom provider. The session border controller provides multiple functions: Security – it acts as a voice-aware firewall, protecting the voice traffic itself and it prevents bad actors from entering the data network via the voice network Interoperability – Ribbon's SBCs can adjust key deployment parameters to best match your telecom provider's requirements, making SIP Link setup easy and trouble-free Legacy Connectivity – many organizations still have analog phones, elevator phones, door phones, and fax machines. Ribbon's hardware-based SBCs have analog ports (FXS and FXO) to keep these assets connected and available. Migration – organizations may have technical or business requirements that require the old PBX to stay connected for an extended period. Ribbon SBCs can provide SIP forking and simultaneous ringing so that both Google Voice and the legacy PBX share connectivity. Resiliency or Failover – Ribbon SBCs have multiple options to manage disruptions in service depending on the deployment model. These tools can keep your organization connected even if the unexpected happens. For more information, go to: https://ribboncommunications.com/solutions/enterprise-solutions/securing-communications-sip-trunks/google-voice-sip-link

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.08.519509v1?rss=1 Authors: Longo, F., Aryal, S., Anastasiades, P., Maltese, M., Baimel, C., Albanese, F., Tabor, J., Zhu, J., Oliveira, M. M., Gastaldo, D., Bagni, C., Santini, E., Tritsch, N. X., Carter, A. G., Klann, E. Abstract: Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted and repetitive behaviours (RRBs). Consistent with observations in humans, FXS model mice display distinct RRBs and hyperactivity that are consistent with dysfunctional cortico-striatal circuits, an area relatively unexplored in FXS. Using a multidisciplinary approach, we dissected the contribution of two populations of striatal medium spiny neurons (SPNs) in the expression of RRBs in FXS model mice. We found that dysregulated protein synthesis at cortico-striatal synapses is a molecular culprit of the synaptic and ASD-associated motor phenotypes displayed by FXS model mice. Cell-type-specific translational profiling of the FXS mouse striatum revealed differentially translated mRNAs, providing critical information concerning potential therapeutic targets. Our findings represent the first evidence of a cell-type specific impact of the loss of FMRP on translation and the sequence of neuronal events in the striatum that drive RRBs in FXS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Sam K. comes back to the pod to discuss the state of Frax, whats next on the building list. Fed master accounts, FrxETH, FXS, FPI and more.NEED LIQUIDITY? TRY FRAXSWAP TODAY! https://app.frax.finance/swap/main~~~~Follow FlywheelpodTwitter: https://twitter.com/flywheelpodTelegram: https://t.me/flywheelpod~~~~Listen to Flywheelpod Wherever You Listen to Podcasts:Spotify: https://open.spotify.com/show/34xXNO289naHrPB2h4uN4JApple Podcasts: https://podcasts.apple.com/us/podcast/flywheel/id1628697864~~~~Connect with DeFi Dave:Twitter: https://twitter.com/DeFiDave22~~~~Connect with KietTwitter: https://twitter.com/0xkapital_k~~~~Connect with Producer SamTwitter: https://twitter.com/traders_insightTelegram: https://t.me/ssmccul~~~~Not financial or tax advice. This channel is strictly educational and is not investment advice or a solicitation to buy or sell any assets or to make any financial decisions. This video is not tax advice. Talk to your accountant. Do your own research.Timeline

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.15.508178v1?rss=1 Authors: Mitchell, M., Cook, L. F., Shiers, S., Tavares-Ferreira, D., Akopian, A. N., Dussor, G., Price, T. J. Abstract: Fragile X Mental Retardation Protein (FMRP) regulates activity-dependent RNA localization and local translation to modulate synaptic plasticity throughout the CNS. Mutations in the FMR1 gene that hinder or ablate FMRP function cause Fragile X Syndrome (FXS), a disorder associated with sensory processing dysfunction. FXS pre-mutations are associated with increased FMRP expression and neurological impairments including sex dimorphic presentations of chronic pain. In mice, FMRP ablation causes dysregulated DRG neuron excitability and synaptic vesicle exocytosis, spinal circuit activity, and decreased translation-dependent nociceptive sensitization. Activity-dependent, local translation is a key mechanism for enhancing primary nociceptor excitability which promotes pain in animals and humans. These works indicate that FMRP likely regulates nociception and pain at the level of the primary nociceptor or spinal cord. Therefore, we sought to better understand FMRP expression in the human dorsal root ganglion (DRG) and spinal cord using immunostaining in organ donor tissues. We find that FMRP is highly expressed in DRG and spinal neuron subsets with substantia gelatinosa exhibiting the most abundant immunoreactivity in spinal synaptic fields. Here, it is expressed in nociceptor axons. FMRP puncta colocalized with Nav1.7 and TRPV1 receptor signals suggesting a pool of axoplasmic FMRP localizes to plasma membrane-associated loci in these branches. Interestingly, FMRP puncta exhibited notable colocalization with calcitonin gene-related peptide (CGRP) immunoreactivity selectively in female spinal cord. Our results support a regulatory role for FMRP in human nociceptor axons of the dorsal horn and implicate it in the sex dimorphic actions of CGRP signaling in nociceptive sensitization and chronic pain. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

HighLife Samples Uplifting Trance. With 5 different construction kits, this sample pack features high-quality Wav loops, MIDI files and synth presets to make your own trance music. Get ready to take your trance production skills to the next level with the Uplifting Trance Sample Pack. With five highly versatile construction kits and an overflowing amount of professional-sounding materials, you'll find everything you need to create long-lasting, high-quality trance tracks. This sample pack features Wav loops, of Drums, Bass, Synth, and Fxs. MIDI files and synth presets from Sylenth and Spires VSTi are also included. All these will help you to make your own trance music and take your tracks to the next level. For easy navigation, all folders and sounds are named with a key and bpm. What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and suitable for genres such as Trance, Psychedelic Trance, and Progressive Trance. Please note: To run the presets you will need Spire version v1.5 and Sylenth1 v3. 067 or higher.   Pack Content: 5 Construction Kits 44 Drum Loops 48 Fx 10 Bass Loops 28 Midi Files 26 Synth Loops 34 Spire Presets 29 Sylenth Presets

A long time coming, we are proud to present @athousanddetails at the helm of this month's ALT CAST. Gustavo Lima, aka A Thousand Details can be considered possibly as one of the most important rising artist of Portugal ́s techno scene. In the recent years this Porto based producer has established himself at the forefront of Portugal ́s next generation of techno DJs. With releases in different labels, his home is ATD Records, a self-release label with a 100% Made in Portugal concept. Known for fast paced, dark and somewhat distorted rhythms this energetic and charismatic Dj is huge fan of hardware synthesizers, FXs, drum machines, Eurorack and his studio is own sanctuary of creation. Gustavo place emphasis on all crevices of the electronic music spectrum, which is reflected on side projects doing ambient and drone music and the sets he pieces together from his sound collection. A Thousand Details has fast become recognized as a seasoned digger having the opportunity of playing throughout Portugal and at most of the major clubs in Porto such us GARE, Plano B as well as Neopop festival.

Let's take a look at my current portfolio suggestions. Remember, we are not traders. We are risk managers building a portfolio that is strong in both a down and up market. You need to look at the big picture in order to be a good investor. Make adjustments slowly over time. 30% ETH 5% BTC 5% FXS FPIS on chain only locked 5% stable coin risk assets - MKR, BTRFLY, Yearn?, Tribe, CRV/CVX? 5% Other: Aave, Uni, Graph, Lido 50% stable coins earning Yield Beginners: Gemini exchange FPI and Volt - coming soon! Advanced - On chain pools curve pools - stake crv? FXS staking options - Guni, afrax, other chains? (avalanche) Compound and Aave? Check gas prices here: https://www.blocknative.com/gas-estimator What I cover: 00:00 Intro 02:44 How much of your savings do you want in crypto? 04:19 Your own chain vs exchange 05:45 Portfolio targets 22:10 Beginner options coming soon 25:46 Advanced options 33:44 Outro ------------------------------------------------------- Join me on Discord: https://discord.gg/sc28FPVyv2 Youtube: https://www.youtube.com/channel/UCT4X1qiEPR0gsZYfze6JOyA Twitter: https://twitter.com/davelevine0com

DeFi Slate Stablecoin Yield Pool Is Live: Participate in the crypto revolution on Polygon offering tiny gas fees and outsized stablecoin returns with DeFi Slate by your side!Spotify | YouTube | iTunes DeFi Slate Fam:Stablecoin wars are here and they are in full force. The best yields in DeFi, the strongest designs, and everything in between.One of the OG stable coins in DeFi that has never had a 1% peg movement and has a considerable advantage over others in terms of Lindy effect (basically, its been around longer than some of the newer ones/has a better track record) is $FRAX.Frax Finance is a fractional reserve, two-token system with the $FXS token.The founder, Sam Kazemian joined us on this episode of DeFi By Design to explain the future of stable coins, curve/convex wars, new 4pool, his relationship with Do Kwon, and what his vision for the multi chain stablecoin world is.Its exciting and Frax has a chance to be THE decentralized stablecoin of DeFi.Listen closely, there’s some really good snippets in here.Cheers,- AndyP.S. We want to introduce you to DeFi Income. Your one-stop shop for earning passive yield through stablecoin staking. Earn high yields with little to no effort on your end. Let myself and our trusted team do the work for you!We offer non-custodial options through our partners at dHEDGE as well as custodial solutions through Trustology. We’ve spent hours with our legal team as well as thousands of $$$ to get this setup, check out our website here!🙌 Sponsor Spotlight: Zerion, the #1 place to invest in DeFi! Swap, earn, borrow, lend!🎙 DeFi by Design EP71: FRAX Stablecoin Strategy DebunkedTogether with: Degate, a Decentralized Layer 2 Exchange based on optimistic rollups. DeGate will offer secure order-book trading that is faster and cheaper than mainnet. Degate also offers a fast and efficient L1 - L2 Bridge, testnet is operating now. Try it HERE!DeFi Saver, is your hub for advanced DeFi management including automation and liquidation protection on Aave & MakerDAO. Join their discord to learn more about the community!DeversiFi is a layer 2 exchange providing deep order books so you can avoid gas costs and frustration, saving you time and money with every trade or swap. DeFi should be open to everyone, not just whales. Join their community on Discord now!QiDAO is one of the newer, most exciting DeFi primitives that introduces ZERO interest loans to DeFi. Their money market product along with their stable coin $MAI is available on Polygon, Avalanche, Fantom and Ethereum! Multichain MAXIS! Check it out, and get your first ZERO interest loan in DeFi! Join their community on Discord now!GoGo is building the world's first non-custodial, decentralized asset manager using NFT smart vaults and is allowing ANYONE to start yield farming on polygon with just a few clicks! So easy your grandma could do it! Join their community on Telegram now!Dhedge is a decentralized asset management protocol facilitating the future of co-investing & fund management. When you invest in top performing pools you earn rewards in DHT tokens! Join their community on Telegram now!🔥 Partner Project UpdatesPolygonHermez is an open-source ZK-Rollup optimized for secure, low-cost and usable token transfers on the wings of Ethereum. Check it out here!Notional Finance is a protocol on Ethereum that facilitates fixed-rate, fixed-term crypto asset lending and borrowing through a novel financial instrument called fCash.  Check it out here!Zerion is a DeFi dashboard AND mobile app that enables any smartphone holder, anywhere in the world, to build and manage their decentralized finance (DeFi) portfolio. Check it out here!Pangolin is a community-driven decentralized exchange with fast settlement, low transaction fees, and the best trading opportunities to maximize your yield. Check it out here!Make sure to check out the Pangolin Roadmap Q1 2022: HERE⚠️ DISCLAIMER: Investing into cryptocurrency and DeFi platforms comes with inherent risk including technical risk, human error, platform failure and more. At certain points throughout this post, we might get commission for promoting certain projects, if this is the case we will always make sure it is clear. We are strictly an educational content platform, nothing we offer is financial advice. We are not professionals or licensed advisors.Liked this post? Share with a friend :)🚨 Want to learn DeFi from Silicon Valley Investors & Entrepreneurs? Check out the DeFi Masterclass Here!🌐Check Us Out On Twitter!🚀Join the community on Telegram Channel to get our free V.1. yield farming guide!🎤Subscribe to our YouTube channel!👩‍💻Join the DeFi Slate DAO Discord Server!🖼 Interested in NFTs? Check out our new project NFT Slate!Last week in review:[ETH Denver Exclusive] Smart Contract Notifications w HAL.xyz🎙 DeFi by Design EP70: veTokenomics, DeFi Revival, & Sustainability with Balancer DAO[ETH Denver Exclusive] MEV Protection w CowSwapCheck out some previous interviews:DeFi Slate x Nate Hindman: AMMs & Bancor V2DeFi Slate x TheEther: A social governance experience for EthereumDeFi Slate x Jeff Jihoz: Web 3.0 Gaming Axie InfinityDeFi Slate x Nick Fett: Oracles, Tellor, and the future of DeFiRecent tweet This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit defislate.substack.com

Sam Kazemian is the founder of Frax, the fractional-algorithmic stablecoin protocol. After co-founding the decentralized Wikipedia startup Everipedia, Sam set out to pioneer the algorithmic stablecoin space. The FRAX stablecoin now has a market cap of over $2.6 billion, and the protocol's FXS governance token is up 300% in the last year.  In this episode, we explore the Stablecoin Wars, in which different protocols compete for liquidity and composability in DeFi. Sam brings a 1st-person perspective into the developments surrounding UST and the recently launched 4pool on Curve, which consists of stablecoins UST, FRAX, USDT, and USDC. A highlight of this conversation is Sam's parable of an archetypal central bank, in which he cruises through a number of salient takes on money markets and macroeconomics. There is a lot to learn about this Cambrian explosion of financial technology, and Sam is a great teacher. Stick around to find out why walked away from this conversation bullish on Frax. ------

Kevin Zhou, co-founder of Galois Capital, discusses a crazy week in the world of algorithmic stablecoins that saw USDN de-peg from the dollar and Terra unveil plans to create a new liquidity pool on Curve to strengthen UST. Show highlights: how USDN and Waves works what made USD de-peg why Kevin thinks algorithmic stablecoins fail so often what Kevin thinks about backing UST with BTC how 4pool works in the context of Curve Finance, 3pool, UST, Frax Finance, and Redacted Cartel why Kevin believes Anchor is the reason UST could de-peg what might happen to Terra and the crypto market writ large if UST were to de-peg why lowering yields on Anchor could depress LUNA's price by 8x how UST and LUNA redemptions work Thank you to our sponsors! Crypto.com: https://crypto.onelink.me/J9Lg/unconfirmedcardearnfeb2021     Coinchange: https://coinchange.io    OnJuno: https://onjuno.com/  Galaxis: https://galaxis.xyz/ Episode Links   Kevin Zhou LinkedIn: https://www.linkedin.com/in/kevin-zhou-82938324/  Galois Capital: https://twitter.com/Galois_Capital    UST Proposal https://agora.terra.money/t/ust-goes-interchain-the-4pool-and-redacted-cartel/5648 Why Terra would want to implement 4pool (in the context of the curve wars) https://twitter.com/CryptoHarry_/status/1510244225304117252  Do Kwon on trying to make DAI less relevant https://twitter.com/stablekwon/status/1511017532764803078  FXS price jump https://www.coindesk.com/markets/2022/04/04/frax-finances-fxs-jumps-as-terra-introduces-stablecoin-pool-4pool/  Galois Twitter threads https://twitter.com/Galois_Capital/status/1511455703642394628  https://twitter.com/Galois_Capital/status/1511198930951938049  UST vs LUNA market cap risk https://twitter.com/0xHamz/status/1506372692005593090  https://twitter.com/Galois_Capital/status/1511198930951938049  https://twitter.com/Galois_Capital/status/1507651829366145030  Why curve wars matter https://twitter.com/JackNiewold/status/1511484763630194699  Terraform Labs' CEO Do Kwon's appearance on Unchained https://www.youtube.com/watch?v=NMRbP_b4JXM  Anchor https://medium.com/@_0xfr/anchor-protocol-how-the-dev-team-rigged-liquidations-a188fb87a99f  USDN Recap of Waves x Alameda Drama https://thedefiant.io/waves-ftx-ponzi-accusations/  OG thread pointing out Waves market manipulation https://twitter.com/0xHamz/status/1509581295621451779  https://twitter.com/0xHamz/status/1502381061925261312  Waves founder blaming Alameda https://twitter.com/sasha35625/status/1510589983920656385 Governance proposal to kill Alameda's short ​​https://unchainedpodcast.us19.list-manage.com/track/click?u=0085a41334b3edf854fd51f9b&id=2fb7761d5b&e=3c1178619e  

Kevin Zhou, co-founder of Galois Capital, discusses a crazy week in the world of algorithmic stablecoins that saw USDN de-peg from the dollar and Terra unveil plans to create a new liquidity pool on Curve to strengthen UST. Show highlights: how USDN and Waves works what made USD de-peg why Kevin thinks algorithmic stablecoins fail so often what Kevin thinks about backing UST with BTC how 4pool works in the context of Curve Finance, 3pool, UST, Frax Finance, and Redacted Cartel why Kevin believes Anchor is the reason UST could de-peg what might happen to Terra and the crypto market writ large if UST were to de-peg why lowering yields on Anchor could depress LUNA's price by 8x how UST and LUNA redemptions work Thank you to our sponsors! Crypto.com: https://crypto.onelink.me/J9Lg/unconfirmedcardearnfeb2021     Coinchange: https://coinchange.io    OnJuno: https://onjuno.com/  Galaxis: https://galaxis.xyz/ Episode Links   Kevin Zhou LinkedIn: https://www.linkedin.com/in/kevin-zhou-82938324/  Galois Capital: https://twitter.com/Galois_Capital    UST Proposal https://agora.terra.money/t/ust-goes-interchain-the-4pool-and-redacted-cartel/5648 Why Terra would want to implement 4pool (in the context of the curve wars) https://twitter.com/CryptoHarry_/status/1510244225304117252  Do Kwon on trying to make DAI less relevant https://twitter.com/stablekwon/status/1511017532764803078  FXS price jump https://www.coindesk.com/markets/2022/04/04/frax-finances-fxs-jumps-as-terra-introduces-stablecoin-pool-4pool/  Galois Twitter threads https://twitter.com/Galois_Capital/status/1511455703642394628  https://twitter.com/Galois_Capital/status/1511198930951938049  UST vs LUNA market cap risk https://twitter.com/0xHamz/status/1506372692005593090  https://twitter.com/Galois_Capital/status/1511198930951938049  https://twitter.com/Galois_Capital/status/1507651829366145030  Why curve wars matter https://twitter.com/JackNiewold/status/1511484763630194699  Terraform Labs' CEO Do Kwon's appearance on Unchained https://www.youtube.com/watch?v=NMRbP_b4JXM  Anchor https://medium.com/@_0xfr/anchor-protocol-how-the-dev-team-rigged-liquidations-a188fb87a99f  USDN Recap of Waves x Alameda Drama https://thedefiant.io/waves-ftx-ponzi-accusations/  OG thread pointing out Waves market manipulation https://twitter.com/0xHamz/status/1509581295621451779  https://twitter.com/0xHamz/status/1502381061925261312  Waves founder blaming Alameda https://twitter.com/sasha35625/status/1510589983920656385 Governance proposal to kill Alameda's short ​​https://unchainedpodcast.us19.list-manage.com/track/click?u=0085a41334b3edf854fd51f9b&id=2fb7761d5b&e=3c1178619e  

Stable coins are for liquidity to use to buy inexpensive risk assets during a downturn. Prioritize safety: time, volatility and size. APY is secondary and only if safe. Portfolio distribution of Stable coins: GUSD 5% https://www.youtube.com/watch?v=aMwqbT26qbQ USDC 25% BUSD - Paxos ? DAI 50% +MKR RAI 5% -FLX FEI 5% ?Tribe Frax 5% ++FXS https://www.youtube.com/watch?v=MZ1iivVPMqA UST 5% -+LUNA https://www.youtube.com/watch?v=HalH-ltIGhk OHM - ? https://www.youtube.com/watch?v=MMcbKO8IiSE Great article on stable coins https://docsend.com/view/ajcbq2dd22yunxqn ------------------------------------------------------- What I cover: 00:00 Intro 00:44 Is it safe? 02:00 Types of stable coins 03:00 Fiat backed coins 09:14 Decentralized coins 14:41 Defi 2 coins 31:45 Final thoughts 33:05 Outro ------------------------------------------------------- Join me on Discord: https://discord.gg/sc28FPVyv2 Youtube: https://www.youtube.com/channel/UCT4X1qiEPR0gsZYfze6JOyA Twitter: https://twitter.com/davelevine0com

We are thrilled to welcome writer, producer, actor and special effects expert Elizabeth Piper and the cast of the Dark Offerings (Amazon) - Terry Alexander (Day of the Dead), Benjamin Frankenberg, Tina Nikolova, Paul Sheehan -  to the FNM family. We discuss the making of this innovative horror film, practical FXs and what it means to make a horror film in quarantine, only using video calls. We are also pleased to announce that no demons (that we know of) appeared on the Zoom call while recording.  Links: https://instagram.com/elizabethpipers  https://instagram.com/paulpsheehan https://instagram.com/thereallyrealtina https://instagram.com/inplaceoffallenstars https://instagram.com/gofortalex7 Sign up for the Friday Night Movie Newsletter for giveaways, curated episode playlists from the hosts and guests (including our mom), and at MOST one email per month (and probably fewer).  The Friday Night Movie Family supports the following organizations: NAACP Legal Defense Fund | Equal Justice Initiative | Asian American Journalists Association. Subscribe, rate and review us on your favorite podcast platform, including iTunes | Spotify | Stitcher | Google Play | Podbean | Overcast. Play along with Friday Night Movie at home! Read the FNM Glossary to learn the about our signature bits (e.g., Buy/Rent/Meh, I Told You Shows, Tradesies, etc.) and then head on over to our merch store your very own official FNM t-shirt.  Send us your recommendations and your tradesies! We'll watch them and report back on the show! Email us at pancake@pancake4table.com or tweet @FriNightMovie, @pancake4table, @chichiKgomez, and/or  @paperBKprincess.  Follow our creations and zany Instagram stories @frinightmovie and @pancake4table. Follow us on Letterboxd (@pancake4table) where we're rating every movie we've EVER watched.  Subscribe to our quarterly newsletter for exclusive giveaways and news! Theme music by What Does It Eat.  Subscribe and leave a review on IOS or Android at fridaynightmoviepod.com.

Everybody's favourite video! Portfolio recommendations, updates and where to put your money! No matter what I predict (or anyone else), you want your portfolio set up so that if the market goes up you make a lot of money but if it goes down you are in a position to buy stuff cheap. Recommendations: - Cash 20-30%: Most people think that's insane, but we aren't most people! This is liquid money that won't go down. Alternatively, you can look into Gemini exchange (GUSD) and earn 8% interest. - Stablecoins: DAI 50%, USDC 25%, RAI 10%, Frax 10% - Ethereum 10% Layer 2's and new layer 1's are higher risk and I'm not interested in them right now. I recommend being very careful if you want to get into them. But maybe they will be attractive to me someday. - Other risk tokens 10%: Looking for things with good fundamentals. Uniswap, MKR, FXS, Aave, Comp - Safe and boring: Real estate - 10-20% BRK.B 5-10% - Risk Stocks: counter trend ARKG Commodities (RIO, GOLD) TSLA? * I forgot to mention International stock ETF's because it got cut off on my printer! EWS, EWY, EPY ------------------------------------------------------- Join me on Discord: https://discord.gg/sc28FPVyv2 Podcast: https://open.spotify.com/show/3yoMRmyZyAKpGvKk97xiGX Twitter: https://twitter.com/davelevine0com ------------------------------------------------------- Timestamps: 0:00 Intro 1:03 Recommendations - Cash 3:45 Stable coins 6:23 Ethereum 10:16 Other risk tokens 13:34 Safe & boring 16:51 Risk Stocks 22:02 Outro

Dans cette #MinuteMarché, nous allons faire un tour sur le S&P500 et le DXY puis nous verrons le Bitcoin, le FTM et FXS!

Dans cette #MinuteMarché, c'est l'heure de revoir ses plans! On fera un tour sur le Bitcoin, l'ATOM, le CRV, le FXS et je vous expliquerai quels sont mes nouveaux plans pour les jours à venir! Si ce format vous à plu je vous invite à vous abonner et à activer les notifications sur les podcasts. Vous pouvez aussi me retrouver sur mes différents réseaux sociaux comme Twitter, Twitch et Discord. Si le trading est quelque chose qui vous intéresse, j'ai pour vous toute une formation entièrement gratuite disponible sur ma chaine Youtube "CaptainTrading". Merci d'avoir écouté ce podcast et Bon trading à tous!

'Modern Future Bass' by Big Sounds features 5 ready Construction Kits of modern Pop music. If you are producing Pop radio music, then this sample pack will help you to take your track to the next level. Inside, you'll find loops of drums, bass, synths, vocal chops and FXs including uplifters, downlifters, impacts, and ambiences. MIDI files are also included for each Construction Kit. You can edit the MIDI files and create brand new melodic ideas in minutes, assign your own favorite VSTi instrument or hardware of your choice, all of this without any audio limitation. Synth presets for Serum, Spire, and Sylenth1 are also included for each Construction Kit. Please Note: To run the VSTi presets you will need Sylenth1 v3.067, Spire v1.15.7 and Serum 1.309 or higher. What's more, everything you get is Royalty-Free. Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs. Product Details: 5 Construction Kits 47 Drum Loops 26 Synth Loops 4 Vocal Chops 24 MIDI Files 98 Stem Files 20 FXs 6 Serum VSTi Presets 4 Spire VSTi Presets 12 Sylenth1 VSTi Presets

Euphoric Trance vol.2 by HighLife Samples brings quality fresh uplifting euphoric Trance construction kits for trance producers who want to get instant inspiration for their music productions.  Inside this sample pack, you will find 5 construction kits, all kits include loops of Bass, Melodies, Pad Chords, Leads, Plucks chords, drums and FXs including uplifters, downlifters, impacts noises, and risers. Midi files are also included for each construction kit. You can edit the midi files and create brand new melodic ideas in minutes, assign your own favorite VSTi instrument or hardware of your choice, all this without any audio limitation.  All files are BPM and key scale labeled for easy navigation. Euphoric Trance vol.2 sample pack will help you to take your trance tracks to the next level. What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and suitable for genres such as Trance, Psychedelic Trance, and Progressive Trance. Pack Content: 5 Construction Kits 149 Files 34 Midi Files 32 Drum Loops 15 Fxs 46 Synth Loops 22 Bass Loops 14 Spire Presets (Bonus) 3 Sylenth Presets (Bonus) 100% Royalty Free

In this episode of the Ulysses Neuro Podcast, we celebrate Fragile X Awareness Day, which falls on the 22nd July in the US and other countries. We hear from Holly Roos, Community Services Director for the FRAXA Research Foundation, and her youngest child A. Holly is a mother of two children diagnosed with Fragile X Syndrome (FXS) and she shares her experience both as a mother and a carrier, discussing the challenges she has had to face from the very first day, sharing personal life stories and what kind of medical and educational support she had and how important it is to celebrate every single inchstone and milestone. A is 18 and lives in Illinois with Holly. A has just finished high school and is preparing to go to college soon. Holly and A share their experience of living with FXS, discussing the journey they have been on with Parker over the past two decades, and the challenges they have faced and overcome. FXS is a single gene disorder affecting 1 in 4,000 males and 1 in 8,000 females. It is the leading inherited cause of intellectual disability and it is caused by mutation of the FMR1 gene, which in turn reduces the production of the FMRP protein. FMRP is crucial for typical brain development as it controls expression of a number of other neurodevelopmental genes. Two main mutations have been identified: The full mutation giving rise to FXS, and a pre-mutation form in carriers whose children are of greater risk of having FXS. Carriers are also at risk themselves of a neurodegenerative disorder called Fragile X-associated Tremor/Ataxia Syndrome (FXTAS). Currently, despite the considerable progress in research in FXS, there is no cure or approved medication to treat the underlying causes of FXS and related conditions. This is in addition to the challenges faced by individuals with FXS and their families when it comes to diagnosis, support, and education.

TECH CLUBBERS PODCAST W/ A THOUSAND DETAILS Gustavo Lima aka A Thousand Details can be considered possibly as one of the most important rising artist of Portugal´s techno scene. In the recent years this Porto based producer has established himself at the forefront of Portugal´s next generation of techno DJs. With releases in different labels, his home is ATD Records, a self-release label with a 100% Made in Portugal concept. Dj is huge fan of hardware synthesizers, FXs, drum machines, Eurorack and his studio is own sanctuary of creation. ATD has fast become recognized as a seasoned digger having the opportunity of playing throughout Portugal and at most of the major clubs in Porto such us GARE, Plano B as well as Neopop festival. TRACKLIST: Kerrie - False Idols Lakej - Dispersion And Casuality [ Edit Select ] Jeroen Search - Ultra 002 [ STRGHTx ] Ecilo - Java Ancient Code [ Axis Records ] Ricardo Garduno - Misconception [ STRGHTx ] PEG - Mental Demolition [ Affekt Recordings ] PWCCA - Kattegat [ EartToGround ] Moddullar - Carbon ( Kwartz Remix ) [ Fautsection ] A Thousand Details – Prashmar [ ATD ] Alexander Johansson & Mattias Fridell – Nocord [ H-Productions ] James Ruskin - There Was a Time [ EPM Music ] Ritzi Lee – Order [ Mord ] A Thousand Details – Lassiter [ ATD ] Nicolas Volger - Internal Circuit ( Alarico Remix ) [ SYXT ] Skov Bowden – Effecter [ Truncate ] Gothsell - Crujido ( Mark Broom Remix ) [ Sleaze Records ] Blanka - Modern Regulations ( Rhythm Assembler aka MTD Remix ) [ made of CONCRETE ] Fireground – Dualism [ Tresor Records ] LokoDepo - 168a45 [ Raw Raw ] Measure Divide – Dreum [ Clergy ] Albert Chiovenda - Haters Gonna Hate ( Divide Remix ) [ ANAØH Records ] Greenbeam & Leon - Most Unnatural [ Bazovoe Techno ] Hakai - Ningen ( Phase Fatale Remix ) [ Megastructure ] Follow ATD here: Facebook: https://www.facebook.com/athousanddetails Instagram: https://www.instagram.com/athousanddetails/ Soundcloud: https://soundcloud.com/athousanddetails Beatport: https://www.beatport.com/artist/a-thousand-details/373425 Discogs: https://www.discogs.com/artist/4394372-A-Thousand-Details Contact: athousanddetails@gmail.com _____ Follow TECH CLUBBERS here: Web: https://www.techclubbers.com/ Facebook: https://www.facebook.com/TechClubbers/ Instagram: https://www.instagram.com/techclubbers/ Soundcloud: https://soundcloud.com/techclubbers Mixcloud: https://www.mixcloud.com/TechClubbersRadio/ Youtube: https://www.youtube.com/c/TechClubbers Contact: info@techclubbers.com

‘Euphoric Trance Free Sample Pack’ by HighLife Samples brings quality fresh Trance construction kits for trance producers who want to get instant inspiration for their music productions. Inside this sample pack, you will find 4 construction kits, All kits include all Bass Layers and Melody loops, Chords, Leads, Plucks and Pads,FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum loops. We Included also a folder with drum hits ok Kicks and Hi-Hats. Midi files are also included for each construction kit. You can edit the midi files and create brand new melodic ideas in minutes, assign your own favorite VSTi instrument or hardware of your choice, all this without any audio limitation. All files are BPM and key-labeled for easy navigation. What’s more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and suitable for genres such as Trance, Psychedelic Trance, and Progressive Trance. Product Details: 4 Construction Kits 10 Kick Drum 10 Hi-Hat 32 Midi Files 17 Bass Loops 29 Drum Loops 20 Fx 27 Lead Loops

April is Child Abuse and Child Sexual Abuse Awareness Month. Nichole Moehring and her family have weathered the storm of child sexual abuse three times. Her son who is diagnosed with autism and Fragile X Syndrome had a very different level of support and resources than when her neurotypical daughter as they sought justice against the perpetrator. In this episode, Nicole shares their story, and tells us about the agency they created, Voices of Change 2018, which has the mission to build access to safety, healing and justice for sexually abused children with disabilities through advocacy, education and collaboration.  It's an interview that will make you want to take action.Links:Voices of Change 2018: Here Child Abuse Prevention Resource Guide: HereVoices of Change 2018 IG Page: HereLinks for The Landscape PagesLink to The Landscape FB PageLink to The Landscape Instagram PageLink to sign up News LetterLink to The Landscape LinkedIn

Please welcome this week: A Thousand Details | Dj/producer from Porto, Portugal SC: @athousanddetails FB: https://www.facebook.com/athousanddetails IG: https://www.instagram.com/athousanddetails BC: https://athousanddetails.bandcamp.com/ TW: https://www.twitch.tv/athousanddetails/ Gustavo Lima, aka A Thousand Details can be considered possibly as one of the most important rising artist of Portugal´s techno scene. In the recent years this Porto based producer has established himself at the forefront of Portugal´s next generation of techno DJs. With releases in different labels, his home is ATD Records, a self-release label with a 100% Made in Portugal concept. Known for fast paced, dark and somewhat distorted rhythms this energetic and charismatic Dj is huge fan of hardware synthesizers, FXs, drum machines, Eurorack and his studio is own sanctuary of creation. Gustavo place emphasis on all crevices of the electronic music spectrum, which is reflected on side projects doing ambient and drone music and the sets he pieces together from his sound collection. A Thousand Details has fast become recognized as a seasoned digger having the opportunity of playing throughout Portugal and at most of the major clubs in Porto such us GARE, Plano B as well as Neopop festival. Note: Highly recommended his weekly podcast show called ATD Podcast. Thanks for listening and sharing! Next Friday podcast with Hellix @djhellix > Slono - Minimal 2b Rame & Asswann - ER404 Rene Wise & Rodhad - 190204 TE#RA - Patterns NWHR - Observatory Gotshell - Are You There Raimond Ford - Silent Light (Motor Mix) Bebhionn - Solar Irradiance Bernardo Hangar - Bet Tsol - Demorph (A Thousand Details Obscure Mix) Vegim - Wonder Boy Ruptura - Pain Tsol - Demorph (A Thousand Details Bench Work Mix) Alien Rain - Numbers Station Manuel Di Martino - Onde Mark Broom - Mapping Character 1 - Soul Voices II (Chlär Remix) Acclaim To The Gods - Colecrati Lumpitone Gryps - The Order Of The Seraphim Broken English Club - Lord of The Flies

In this episode, Bobby Ong, co-founder of CoinGecko is joined by Sam Kazemian, Founder at FRAX Finance. Bobby interviewed Sam on the background of FRAX, its fractional algorithmic stablecoin, problems with stablecoins, plans to increase FRAX adoption as well as proposed FRAX bond.[00:00:02] Intro[00:01:23] Introduction of FRAX[00:04:32] Use of FRAX Share token (FXS)[00:06:30] Idea of fractional algorithmic stablecoin [00:12:22] Thoughts on problems of stablecoins[00:18:19] Thoughts on market absorption for FRAX[00:23:29] Demand for FRAX[00:38:35] FRAX bond proposalQuotes from the episode:“Right now we only use USDC. The protocol starts at 100% collateralized. As it expands, it'll slowly test lower and lower collateral ratios. And so what that means is the FRAX stablecoin is only backed by USDC at the collateral ratio.” [00:02:32]“One of the main stories that I like to tell about how FRAX came to be after the whole Tether saga.” [00:07:24]“One of the things that's interesting that we're exploring, not finalized, we don't really know if this is what we'll release or anything, but we were thinking of having FRAX be backed by $1 of LP token value.” [00:30:21]LinksFRAX Finance - https://frax.finance/CoinGecko - https://www.coingecko.com/Frax (FRAX) on CoinGecko - https://www.coingecko.com/en/coins/fraxFrax Share (FXS) on CoinGecko - https://www.coingecko.com/en/coins/frax-shareSocial MediaFRAX Finance:https://twitter.com/fraxfinancehttps://t.me/fraxfinanceCoinGecko:https://twitter.com/coingeckohttps://t.me/coingecko

Chain Reaction Host Tom Shaughnessy hosts Sam Kazemian, the Founder of Frax Finance to discuss the project. This is the second in a series of podcasts on Algorithmic stablecoins. The trio discuss Frax’s creation, technicals around expansion/contraction of supply, competition, risks and much more including why Frax could be the most stable vs its competitors. Every Delphi Podcast is dropped first as a video interview for Delphi Digital Subscribers. Our members also have access to full interview transcripts. Join today to get our interviews, first. Thank you to our sponsor LVL, which is launching the first free Bitcoin exchange in North America. Users buy and sell Bitcoin with no trading fees or hidden spreads. Visit them at lvl.co/btcmedia - Show Notes (2:02) – (First Question) - Sam Kazemian's Background.(4:37) – Frax Finance Elevator Pitch.(10:39) – What is being used as Collateral in Frax.(15:50) – Frax Stablecoin vs FXS governance token.(18:23) – Relation between USDC and FXS / Insights about the process.(21:11) – Insights about the Value Capture.(23:34) – The growth process.(25:33) – Where is the Collateral pool kept.(28:48) – What happens when the price of FRAX goes sub $1.(33:18) – How do people earn more of the Governance Token / Rewards Walkthrough.(36:11) – How APY could offset Impermanent Loss.(38:21) – How the Supply of FXS could get absorbed.(39:27) – How many people are Time Locking their Stake.(42:04) – Once you use all the Yield Farming Rewards, What's next.(47:42) – The Dichotomy between ESD and Frax.(54:35) – Where to find Sam Kazemian. Music Attribution: Cosmos by From The Dust | https://soundcloud.com/ftdmusic Music promoted by https://www.free-stock-music.com Creative Commons Attribution 3.0 Unported License https://creativecommons.org/licenses/by/3.0/deed.en_US Resources: Sam’s Twitter: https://twitter.com/samkazemian Frax’s Website: https://frax.finance/ Tom’s Twitter: https://twitter.com/Shaughnessy119 Delphi Podcast Twitter: https://twitter.com/PodcastDelphi More Our Video interviews Can Be Viewed Here: https://www.youtube.com/channel/UC9Yy99ZlQIX9-PdG_xHj43Q Access Delphi’s Research Here: https://www.delphidigital.io/   Disclosures: This podcast is strictly informational and educational and is not investment advice or a solicitation to buy or sell any tokens or securities or to make any financial decisions. Do not trade or invest in any project, tokens, or securities based upon this podcast episode. The host may personally own tokens that are mentioned on the podcast. Lets Talk Bitcoin is a distribution partner for the Chain Reaction Podcast, and our current show features paid sponsorships which may be featured at the start, middle, and/or the end of the episode. These sponsorships are for informational purposes only and are not a solicitation to use any product or service. Delphi’s transparency page can be viewed here.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.12.379800v1?rss=1 Authors: Brighi, C., Salaris, F., Soloperto, A., Cordella, F., Ghirga, S., de Turris, V., Rosito, M., Porceddu, P. F., Reggiani, A., Rosa, A., Di Angelantonio, S. Abstract: Fragile X syndrome (FXS) is a neurodevelopmental disorder, characterized by intellectual disability and sensory deficits, caused by epigenetic silencing of the FMR1 gene and subsequent loss of its protein product, fragile X mental retardation protein (FMRP). Delays in synaptic and neuronal development in the cortex have been reported in FXS mouse models, however, the main goal of translating lab research into pharmacological treatments in clinical trials has been so far largely unsuccessful, leaving FXS a still incurable disease. Here, we generated 2D and 3D in vitro human FXS model systems based on isogenic FMR1 knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines. Phenotypical and functional characterization of cortical neurons derived from FMRP-deficient hiPSCs display altered gene expression and impaired differentiation when compared with the healthy counterpart. FXS cortical cultures show increased proliferation of GFAP positive cells, likely astrocytes, increased spontaneous network activity and depolarizing GABAergic transmission. Cortical brain organoid models show increased proliferation of glial cells, and bigger organoid size. Our findings demonstrate that FMRP is required to correctly support neuronal and glial cell proliferation, and to set the correct excitation/inhibition ratio in human brain development. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.25.311142v1?rss=1 Authors: Agastheeswaramoorthy, K., Sevilimedu, A. Abstract: Drug repositioning is emerging as an increasingly relevant option for rare disease therapy and management. Various methods for identifying suitable drug candidates have been tried and range from clinical symptomatic repurposing to data driven strategies which are based on the disease-specific gene or protein expression, modification, signalling and physiological perturbation profiles. The use of Artificial Intelligence (AI) and machine learning algorithms (ML) allows one to combine diverse data sets, and extract disease-specific data profiles which may not be intuitive or apparent from a subset of data. In this case study with Fragile X syndrome and autism, we have used multiple computational methodologies to extract profiles, which are then combined to arrive at a comprehensive signature (disease DEG). This DEG was then used to interrogate the large collection of drug-induced perturbation profiles present in public databases, to find appropriate small molecules to reverse or mimic the disease-profiles. We have labelled this pipeline Drug Repurposing using AI/ML tools - for Rare Diseases (DREAM-RD). We have shortlisted over 100 FDA approved drugs using the aforementioned pipeline, which may potentially be useful to ameliorate autistic phenotypes associated with FXS. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.22.301762v1?rss=1 Authors: Geoffroy, A., Habbas, K., Zambo, B., Schramm, L., Duchon, A., Flatter, E., Fouillen, L., Zumsteg, J., Heintz, D., Mandel, J.-L., Herault, Y., Moine, H. Abstract: Fragile X syndrome (FXS), the leading cause of familial intellectual disability, is an uncured disease caused by the absence or loss of function of the FMRP protein. FMRP is an RNA binding protein that controls the translation of specific proteins in neurons. A main target of FMRP in neurons is diacylglycerol kinase kappa (DGKk) and the loss of FMRP leads to a loss of DGK activity causing a diacylglycerol excess in the brain. Excessive diacylglycerol signaling could be a significant contributor to the pathomechanism of FXS. Here we tested the contribution of DAG-signaling in Fmr1-KO mouse model of FXS and we show that pioglitazone, a widely prescribed drug for type 2 diabetes, has ability to correct excessive DAG signaling in the brain and rescue behavioral alterations of the Fmr1-KO mouse. This study highlights the role of lipid signaling homeostasis in FXS and provides arguments to support the testing of pioglitazone for treatment of FXS. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.10.291062v1?rss=1 Authors: Bonnycastle, K., Kind, P. C., Cousin, M. A. Abstract: Synaptic vesicle (SV) recycling is essential for the maintenance of neurotransmission, with a number of neurodevelopmental disorders linked to defects in this process. Fragile X syndrome (FXS) results from a loss of fragile X mental retardation protein (FMRP) encoded by the FMR1 gene. FMRP is an established translation repressor, however it also has translation-independent presynaptic roles, including regulation of the trafficking and function of specific ion channels. Since defects in SV recycling are exacerbated during intense neuronal activity, we investigated whether these events were disproportionately affected by the absence of FMRP. We revealed that primary neuronal cultures from a Fmr1 knockout rat model display a specific defect in activity-dependent bulk endocytosis (ADBE). ADBE is dominant during intense neuronal activity, and this defect resulted in an inability of Fmr1 knockout neurons to sustain SV recycling during trains of high frequency stimulation. Using a molecular replacement strategy, we revealed that a human FMRP interaction mutant failed to correct ADBE dysfunction in knockout neurons. Therefore, FMRP performs a key role in sustaining neurotransmitter release via selective control of the endocytosis mode, ADBE. Copy rights belong to original authors. Visit the link for more info

The guys play with the sound FXs on the board. Make fun of Bald Bastards Mother in Law, Barfy makes fun of BB's Mother in-law/ Barfy's god mother, RIP to Bronson the dog, WE Need questions from our listeners for a event. and we talk about starting our own instagram page. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/batbb/message Support this podcast: https://anchor.fm/batbb/support

This week -- Basics of JOINTS!Our joints allow us to move! Learn how to move them…safer!-What are Joints?-How they Move-What are some common unsafe & contraindicated stretches and exercises?Need support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!A journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.05.238568v1?rss=1 Authors: Ding, Q., Wu, X., Li, X., Wang, H. Abstract: Fragile X syndrome (FXS) is caused by mutations in the FMR1 (fragile X mental retardation 1) gene. It is a significant form of heritable intellectual disability with comorbidity of other symptoms such as autism. Due to the lack of efficacious medication, repurposing the existing FDA-approved drugs may offer an opportunity to advance clinical intervention for FXS. Analysis of the whole-genome transcription signatures predicts new therapeutic action of vorinostat to correct pathological alterations associated with FXS. We further find that the administration of vorinostat restores object location memory and passive avoidance memory in the Fmr1 knockout (KO) mice. For the non-cognitive behavioral symptoms, vorinostat corrects the autism-associated alterations, including repetitive behavior and social interaction deficits. In the open field test, vorinostat dampens hyperactivity in the center area of the arena. Surprisingly, vorinostat does not affect the abnormally elevated protein synthesis in Fmr1 KO neurons, suggesting different outcomes from correcting behavioral symptoms and specific aspects of cellular pathology. Our data reveal the therapeutic effects of the FDA-approved drug vorinostat in a mouse model of FXS and advocate efficacy testing with human patients. Copy rights belong to original authors. Visit the link for more info

We all know how to get up & down from the floor, get in & out cars/chairs/beds, pick thing up & put them down, stand, sit, walk.How about how to do it safer so we can do it longer?1. ADLs2. 7 basic motions for all movement3. Joints & range of motion4. Muscle memory & best practices for safer movementIn the webcast, find out what's the probability of being impaired in at least 2 activities of daily living by the age of 65! You'll be glad you did!Has life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!Need support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comA journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.30.228874v1?rss=1 Authors: Kalmbach, B., Brager, D. H. Abstract: Axo-somatic K+ channels control action potential output in part by acting in concert with voltage-gated Na+ channels to set action potential threshold. Slowly inactivating, D-type K+ channels are enriched at the axo-somatic region of cortical pyramidal neurons of the prefrontal cortex where they regulate action potential firing. We previously demonstrated that D-type K+ channels are down regulated in extratelencephalic-projecting L5 neurons (ET) in the prefrontal cortex of the fmr1 knockout mouse model of Fragile X syndrome (FX mice), resulting in a hyperpolarized action potential threshold. To test whether K+ channel alterations are regulated in a cell autonomous manner in FXS, we used a viral-mediated approach to restore expression of Fragile X Mental Retardation Protein (FMRP) in a small population of prefrontal neurons in male FX mice. Outside-out voltage clamp recordings revealed a higher D-type K+ conductance in FMRP-positive ET neurons compared to nearby FMRP-negative ET neurons. FMRP did not affect either rapidly inactivating A-type or non-inactivating K+ conductance. ET neuron patches recorded with FMRP1-298, a truncated form of FMRP which lacks mRNA binding domains, included in the pipette solution had larger D-type K+ conductance compared to heat-inactivated controls. Viral expression of FMRP in FX mice depolarized action potential threshold to near wild type levels in ET neurons. These results suggest that FMRP influences the excitability of ET neurons in the mPFC by regulating somatic D-type K+ channels in a cell autonomous, protein-protein dependent manner. Copy rights belong to original authors. Visit the link for more info

I apologize the beginning is not loud enough!Walking is one of the easiest & safest ways to stay in shape. Doctors recommend it. We're all doing it during quarantine. Can it cause us injuries?Topics discussed today:• Not all pain is gain• Posture• Rhythm/Gait• When to see a Doctor• Tips to safer walkingHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!Need support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comA journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Can lack of sleep cause you to gain weight?Yes, it can cause 11 lbs…annually!This week we discuss:-Signs of sleep depravation-Sleep and weight loss-Sleep and exercise-Issues of possible concern-Tips to healthier sleepNeed support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!A journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Don't Forget to BYOW (Bring Your Own Water) and listen along!How do you know if you're dehydrated? Join us to learn why the key to weight loss is drinking water!Signs & risks of dehydrationWhat does water doHow water helps you lose weightTips to drink more waterNeed support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!A journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Have we gone on auto-pilot, not conscious of how we got to the end of the day? Or bottom of the bowl? This session we talk about:Mindless vs. Mindful eating Mindless eating triggersDisadvantages of Mindless EatingBenefits of mindful eatingTips to eat mindfullyNeed support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!A journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Today's Zoom meet up focused on Carbs:* Why we need carbs!* Carbs and blood sugar* Warnings about "low-carb" diets* Three types of carbs* How many carbs should we eat to lose weightNeed support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!A journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

SabotageWhy it's important to be aware of things that destroy our fitness & weight loss goalsWhy & how we experience sabotageMotivation & setting goalsNeed support on your wellness journey? Join us virtually on Zoom. Follow www.shalainefit.eventbrite.com for our next live discussion. Slideshow, articles and more at http://getfit.shalainefit.comHas life derailed your fitness goals? Health & Wellness is a journey of thousands of steps. It's a culmination of your time and effort! This channel is for beginners, seniors, group fitness professionals, and anyone interested in continued learning about their health, wellness, and fitness. I hope to inspire you to prioritize your health and live your best life by providing you with some whys & hows you might not have known. My goal is to provide interactive shows aimed to connect with your current journey with topics of interest and motivate you with knowledge, tips, and weekly challenges. I'm challenge you to be involved and present for the choices you make for your mind & body!A journey takes thousands of steps, congrats on taking one today!If you learned something from this video, please give it a like & follow my channel. Thank you!DISCLAIMER:The information, including but not limited to, text, graphics, video, images and other material provided ("Content") is for educational purposes only. Content is not intended in any way as a substitute for professional medical advice, diagnosis or treatment.Regardless of your current state of health, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding your current health condition, a medical condition or treatment before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read from Shalaine McLaughlin or Shalaine Fitness LLC ("FxS"). You agree that you are voluntarily participating in these activities and assume all risks of injury, illness, or death. FxS is not responsible for any loss of your personal property.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.26.062281v1?rss=1 Authors: Aryal, S., Longo, F., Klann, E. Abstract: Loss of the fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS). FMRP is widely thought to repress protein synthesis, but its translational targets and modes of control remain in dispute. We previously showed that genetic removal of p70 S6 kinase 1 (S6K1) corrects altered protein synthesis as well as synaptic and behavioral phenotypes in FXS mice. In this study, we examined the gene-specificity of altered mRNA translation in FXS model mice and the mechanism of rescue with genetic reduction of S6K1 by carrying out ribosome profiling and RNA-Seq on cortical lysates from wild-type, FXS, S6K1 knockout, and double knockout mice. We observed reduced ribosome footprint abundance in the majority of differentially translated genes in the cortices of FXS mice. We used molecular assays to discover evidence that the reduction in ribosome footprint abundance reflects an increased rate of ribosome translocation, which is captured as a decrease in the number of translating ribosomes at steady state, and is normalized by inhibition of S6K1. We also found that genetic removal of S6K1 prevented a positive-to-negative gradation of alterations in translation efficiencies (RF/mRNA) with coding sequence length across mRNAs in FXS mouse cortices. Our findings reveal the identities of dysregulated mRNAs and a molecular mechanism by which reduction of S6K1 prevents altered translation in FXS. Copy rights belong to original authors. Visit the link for more info

High Life Samples continues to bring you the most up to date sounds with a fourth volume in a much beloved series. Trance is an art form, and this pack is worthy of any true Trance producer! High Life Samples Art of Trance Vol.4 This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go. All kits include all Bass and Synth loops neatly separated as Dry and Wet, FXs including uplifters, risers, downsweeps, impacts, crashes and noise, and of course all Drum Hits and loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. We also give away all presets (Sylenth1, Spire and Serum) used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the synth preset’s you will Sylenth1 v3.03, Spire v1.1.14, Serum v1.214 or higher is required. Pack Content 877MB of Content 5x Construction Kits 58x Wet Synth Loops 54x Dry Synth Loops 33x Midi Files 13x Bass Dry Loops 11x Bass Wet Loops 21x Drum Hits 20x Drum Loops 19x Fx 25x Spire Preset’s 1x Sylenth Preset 1x Serum Preset

HighLife Samples is back with the third instalment of a much beloved series. This is Trance in its purest form! This is a trance sample pack worthy of any true Trance Artist! HighLife Samples Art of Trance Vol.3 This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go. All kits include all Bass Layers and Melody loops, Chords, Leads, Plucks and Pads, Pianos, FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum Hits and loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. We also give away all presets (Sylenth1, Spire and Massive) used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the synth presets you will Sylenth1 v3.03, Spire v1.1.14, NI Massive v1.4 or higher is required. Pack Content: 829MB of Content 5xConstruction Kits 159x Loops 35x Midi Files 35x Spire Presets 8x Sylenth 1 Presets 1x Massive Preset Kits Root Keys: C#, F#, A#, D# Tempo ranges: 132, 138, 140bpm

Big Sounds Future Bass 2K20 it’s a must have sample pack for Future Bass genre. This sample pack brings you a step closer to the modern future bass sound. Inside you will find 5 construction kits, all sounds and samples can work out of the box without to worry about processing them. All kits include Loops of Melodies, Bass, Chords, Leads, Pianos, FXs and vocal chops including FX’s, and of course all Drum Hits and Drum loops. As an extra bonus we included also the Stems files. Load the stems in your DAW to achieve quick structure/arrangement for every construction kit. Everything is clearly labelled and in key. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. You can find also synth presets from Serum and Spire vst’s. What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the presets you will need Serum v1.214, Spire v1.1.14 or higher is required. Pack Content: 1.80GB of content 5xConstruction Kits 83xLoops 76xStem Files 33xMidi Files 35x Shot Samples 14x Serum Presets 4x Spire Presets

This episode on the podcast today is all about Fragile X. Before we start, I just want to mention that there are a few other names out there for this and some of those are FRAXA syndrome, fraX syndrome, FXS, marker x syndrome, and martin bell syndrome. Throughout this episode, I will be referring to […]

Especial del miércoles. Diatriba sobre la esquina de la 67 con 7a, la Natalia, el epíteto grande, lo qué es ser un hombre, la menstruación, el Blade Runner, los vengadores, los FXs, el Guasón y la angustia de vivir hoy aquí y otro poco de estupideces. El de hoy está largo, escúchenlo hasta el final.

If you are into House, Tech House, Progressive House or Techno you will love this sample pack Melodic House is the new sample pack from Big Sounds Inside you will find Loops for Drums, Bass, Synths and Fxs. We include also Midi files plus the synth presets from Sylenth and Spire. All folders and sounds are clearly labelled with key and bpm and all loops are ready to drop into your next project. Everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the synth presets you will Sylenth1 v3.03, Spire v1.1.14 or higher is required. The Fx’s that you heard in the demo song are not included in the pack as they are part of the master chain. Pack Content: 5x Construction Kits 68x Loops 16x Midis 5x Spire Presets 15x Sylenth Presets Root keys: F, C#, D, G# Tempo: 124bpm

Big Sounds Future Pop Music Vol.2 it’s a must have sample pack if you want to archive the pop sound of today. This pack brings you a step closer to the modern pop. This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go. All kits include Loops of Melodies, Bass, Chords, Leads, Pianos, FXs and vocal chops including FX’s, and of course all Drum Hits and Drum loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. We also give away all Serum presets used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the presets you will need Serum v1.214 or higher is required. Pack Content: • 216 Files in Total • 5 x Construction Kits • 57 x Midi Files • 33 x Shot Samples • 25 x Serum Presets

On this episode, we speak with Danielle Deadwyler. She's a graduate of Spelman College. Danielle is a multidisciplinary performance artist, actor, and filmmaker. She's graced theatre stages, big screens and televisions screens with guest-star roles on BET's Being Mary Jane, OWN's Greenleaf, Tyler Perry's The Haves & The Have Nots and the upcoming Reckoning set to hit theaters this Fall. During this episode, we discuss her HBCU experience and discuss her artistry in depth. SHOW NOTES: Choosing Spelman [10:08] Choosing Acting [19:32] Atlanta's Evolving Entertainment Scene [32:50] Favorite Spelman Memories [49:02] Giving to Spelman [51:32] MORE INFO: Instagram: DanielleDeadwyler Facebook: Danielle Deadwyler Website: danielledeadwyler.com

Jennifer Murphy is a professional makeup artist working in Halifax, Nova Scotia. In 2011 she enrolled at The Blanche MacDonald Centre in Vancouver to complete their Global Makeup Program. The yearlong program was very thorough and covered every module from beauty makeup, airbrushing, all the way to special FXs and prosthetics. She finished the program with honours and made her way back to the east coast of Canada, the place she calls home.In 2013, she began working for MAC Cosmetics and couldn’t imagine a more wonderful opportunity! Working with amazing people and wonderful clients, her hands-on experience at MAC enabled her to meet the varied needs of her clients. The magic of a busy retail setting is that you encounter every different type of person, personality, skin tone, age, and lifestyle. It certainly helped her master her art and confirmed her passion for this industry.She believes that continual learning and staying with new trends in the industry helps create beautiful results for her clients. In 2017, she had the privilege of attending Mario Dedianovic’s Master Class in London, England, to learn his secrets in creating Kim Kardashian’s iconic beauty look. She also completed courses in Microblading with The Extension Academy and Eyelash Extensions with Misencil. It is her pleasure to help clients create their perfect look for every day or even their special day.

We continue the Art of Trance series with the HighLife Samples Art of Trance Vol.2 This pack brings you a step closer to learn how the pros making their Trance tracks. It is time for you to take your productions to the next level. This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go. All kits include both dry and wet Bass and Melody loops, Chords, Leads, Plucks and Pads, Pianos, FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum Hits and loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. We also give away all presets (Sylenth1, Spire, Massive) used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the synth presets you will Sylenth1 v3.03, Spire v1.1.14, NI Massive v1.4 or higher is required Pack Content: 803MB of unzip Content Tempo ranges: 136-140bpm 5x Construction Kits 62x Wet Loops 62x Dry Loops 29x Drum Hits 34x Drum Loops 29x Fx 53x Midi Files 2x Massive Presets 26x Spire Presets 10x Sylenth Presets Construction Kits Rootkeys: E, A#, C#, F, G#

When Missy Zolecki learned that she had a family history of Fragile X syndrome (FXS), she sought out carrier testing, thinking that she and her fiancé would not have children if she learned she was at risk for having a child with FXS. Fast forward 21 years later, Missy and her husband have been married 21 years and have three children, the oldest of whom is 18 years old and has Fragile X syndrome. Missy discusses how her religious faith influenced her decision making process around the option of IVF and Preimplantation Genetic Diagnosis (PGD), available only under a research protocol in 2000. She shares how she moved from anger at medical errors to appreciating the people and the opportunities that her son’s diagnosis of FXS has brought into her life. Missy explains how an accurate diagnosis of Fragile X—the leading genetic cause of autism—can be incredibly helpful in providing optimal care and education for children with Fragile X. She also shares her passion for women being offered preconceptual carrier testing for Fragile X for women, giving them choices and allowing them to make informed decisions. Links and Resources National Fragile X Foundation (NFXF) Connect with the National Fragile X Foundation on Social Media: NFXF on Twitter: @nfxfoundation NFXF on Instagram: @nfxfoundation NFXF on Facebook NFXF on YouTube Other Related Resources CDC recommendations and guidelines related to diagnosis and evaluation of ASD The CDC on Fragile X Check out other Patient Stories podcast episodes. Read other Patient Stories on the Grey Genetics Patient Stories Page Do you want to support Patient Stories? You can now make a donation online! Want to support Patient Stories in a non-monetary way? Leave us a review on iTunes, or share your favorite episodes on Social Media. Patient Stories on Twitter: @GreyGeneticsPod Patient Stories on Instagram: @patientstoriespodcast Are you looking for genetic counseling? Patient Stories is sponsored by Grey Genetics, an independent telehealth genetic counseling and consulting company. Book an appointment with a genetic counselor specialized in your area of concern. All genetic counseling appointments take place over secure, HIPAA-compliant video-conferencing or by phone. Looking for some guidance but not ready to book a genetic counseling appointment? You can also check out our new review services here.

‘Bass House Samples’ is the brand new sample pack by Big Sounds. Inspired by AC Slater Jauz and Twoloud to bring you a full of inspiration sample pack. Inside you will find 5 construction kits, all kits includes loops from bass, leads, drums, fx and vocals. You can find also midi files, presets from Serum and a folder with stems files for ultra-flexibility. As a bonus we include a folder with 40 vocal phrases that are suitable for Bass House Music. All folders are clearly labelled with key and bpm and all sounds are ready to drop into your next project. To import the serum presets you will need Serum v1.214 or higher. Everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: • 1.7GB of Content • 5 x Construction kits • 23 x Bass Loops • 25 x Drum Loops • 7 x Fxs • 8 x Lead Loops • 23 x MIDI Files • 23 x Serum Presets • 94 x Stem Files • 10 x Vocal Loops from Construction Kits • 40 x Vocal Phrases

We here at HighLife Samples pride ourselves in our art. And Trance in itself is an art form we have mastered well! This pack brings you a step closer to 138bpm perfection... It is time for you to become a true Trance Artist! HighLife Samples Art of Trance Vol.1 has been produced by talented producer TranceMaster. This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go. All kits include both dry and wet Bass and Melody loops, Chords, Leads, Plucks and Pads, Pianos, FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum Hits and loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. We also give away all presets (Sylenth1, Spire, Massive and Dune 3) used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Please note: To run the synth presets you will Sylenth1 v3.03, Spire v1.1.14, NI Massive v1.4 and Dune 3.02 or higher is required Pack Content: 1.14GB of unzip Content Tempo ranges: 138-140bpm 5x Construction Kits 173x Wet Loops 173x Dry Loops 26x Drum Hits 29x Drum Loops 57x Fx 53x Midi Files 4x Dune 3 Presets 5x Massive Presets 26x Spire Presets 10x Sylenth Presets

Divine Parables - The Example of the Denier Part 3 05/13/19

Deadbeat at Dawn Major cult classic alert!! Yeah, this may not be a "horror" movie but Deadbeat at Dawn is the real deal in the gore and practical FXs department! Part Deathwish, part martial arts, part sleazy splatter, this movie is 100% Bladejob Approved! Then it's on to another gore fest from 1988... SuperClash III, where the fellas talk about the infamous gusher between Kerry Von Erich and Jerry Lawler. This is a must see match for fans of 80s wrestling and one of the few times in that era a match was actually stopped for blood loss!Deadbeat at Dawn trailer https://www.youtube.com/watch?v=_Zu9NnkfGK4SuperClash III match (better quality version on WWE Network) https://www.youtube.com/watch?v=S3SpyLuztiYSupport Bladejob by donating to their Tip Jar: https://tips.pinecast.com/jar/bladejobFind out more at https://bladejob.pinecast.co

It’s all about energy, euphoria and catchy melodies. Three must have elements for Trance music. The brand new Power Energetic Trance sample pack by HighLife Samples has it all. With powerful energetic rolling basses, energetic plucks and memorable melodies, HighLife Samples Power Energetic Trance is a sample pack full of inspiration that you will definitely incorporate in your tracks! This pack offers the greatest tools and source of inspiration you have been missing! It will help you to add trance flavor in your tracks. With your purchase, you get 5 complete construction kits ready to go! All kits include both dry and wet Bass and Melody loops, Chords, Leads, Plucks and Pads, FXs including uplifters, downlifters, impacts, noises and sweeps, and of course all drum hits and drum loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. You can import the midi files inside your DAW, re-arrange the midis and come up with something unique. Everything is clearly labelled and in key. Kit’s tempo: 138-140bpm. We also give away all presets (Sylenth, Spire and Massive) used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: 5x Power Energetic Trance Kits 49x Dry Bass and Melody 49x Wet Bass and Melody 33x Drum Loops 28x Drum Hits 40x Fx’s 45x Midi Files 25x Spire Presets 3x Sylenth Presets 4x Massive Presets

Are you the kind of person who lives for the build up and explodes with a massive drop? Big Sounds has got you covered, and is always up to date with the current soundscape. Big Sounds presents EDM 2019 Big Drops. This is a pack that you definitely don't want to miss! Inside you will find 5 construction kits, offering the greatest tools and source of inspiration you have been missing. All kits include buildups, breakdowns, drops, fills and main Bass loops, Melodies, Chords, Leads, Plucks and FX, including uplifters, downlifters, impacts and noise, and of course all drum loops and the final mixdown. What's more, we have included the midi files for all melodic elements. All folders are clearly labelled with key and bpm and all sounds are ready to drop into your next project. Everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: • 5 x Fresh EDM Construction Kits • 22 x MIDI Files • 26 x Drum Loops • 55 x Melodic Loops (Chords, Bass, Leads) • 6 x Fxs

HighLife Samples is back with the fifth release of series Power Trance. This new trance sample pack is dedicated to Epic Trance. With powerful basses, energetic plucks, choirs and memorable epic melodies, HighLife Samples Power Epic Trance is a sample pack full of inspiration that you will definitely want to be add in your tracks! This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go! All kits include Bass, Melody loops, Pads, Choirs and Arps in 4-5 synths layers. FXs including uplifters, downlifters, risers, impacts, noise, and of course all drum hits and drum loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. We also give away all presets (Sylenth, Spire) used to create this sample pack. Each construction kits is clearly labelled and in key. For synth presets you will need Sylenth v3.0.3, Spire v1.1.12 What’s more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: 5xEpic Trance Construction Kits 7x Choirs 26x Drum Hits 32x Drum Loops 22x Fx 37x Midi Files 26x Spire Presets 1x Sylenth Preset 46x Synths Loops

David Cunningham Owens is Professor of Clinical Psychiatry at the University of Edinburgh and honorary consultant psychiatrist, the Royal Edinburgh Hospital. This talk revealed how the development of neuronal communication at synapses is altered in Fragile X Syndrome (FXS). It also examines how basic research into the role of genetics has led to the development of new medicines for treating FXS and hopefully will result in treatment possibilities for some forms of autism. This lecture is part of the Medical Detectives, a series of public lectures that show how keen detective work is still essential for 21st century doctors: http://www.ed.ac.uk/news/events/medical-detectives/ Recorded on 20 September 2012 in the Anatomy Lecture Theatre at the University of Edinburgh.

It’s time to up your game and send the crowds into a Euphoric state of mind! What better way to achieve this than with Highlife Samples new soundware pack, Power Euphoric Trance. With powerful rolling basses, energetic plucks and memorable melodies, HighLife Samples Power Euphoric Trance is a pack full of inspiration that you will definitely incorporate in your tracks! This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go! All kits include both dry and wet Bass and Melody loops, Chords, Leads, Plucks and Pads, Pianos, FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum Hits and drum loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. We also give away all presets (Sylenth, Spire and Massive) used to create our unique sounds! What’s more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: 5x Power Euphoric Trance Kits 48x Bass and Melodies Dry Loops 48x Bass and Melodies Wet Loops 26x Drum Loops 21xDrum Hits 28x Fxs 38x Midi Files 20x Spire Presets 4x Sylenth Presets 1x Massive Preset

Big Sounds is back with another top notch sample pack. This time we bring you a new EDM trend sample pack called Brazilian B-House. Inspired by artists such as, Tiesto, Sevenn, Alok, Ricci, Groove Delight and many more.This pack has just what you need and definitely don't want to miss! In it you will find 10 starter loop kits, offering the greatest tools and source of inspiration you have been missing. All kits include Drum Loops, Bass loops, Pluck and Lead Loops. With each kit, you also get the midi files for the Bass, Lead, and Pluck Loops.All starter kits sounds are clearly labelled with key and bpm and ready to drop into your next project. Everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want.Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: • 10 x Starter Loop Kits • 50 x Drum Loops • 10 x Midi Files of Bass Loops • 10 x Midi Files of Pluck, Lead Loops • 7 x Fxs • 10 x Bass Loops Wav • 10 x Pluck, Lead Loops Wav

Progressive Trance holds a special place in our hearts, and HighLife Samples is the Trailblazer when it comes to bringing you high quality and never before heard Sample Packs! With powerful rolling basses, hypnotic pads and energetic plucks, HighLife Samples Power Progressive Trance is the only pack you will need for the foreseeable future! This pack offers the greatest tools and source of inspiration you have been missing! With your purchase, you get 5 complete construction kits ready to go! All kits include both dry and wet Bass and Melody loops, Chords, Leads, Plucks and Acids, FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum Hits and Drum Loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. Everything is clearly labelled and in key. In each construction kits you will find also all presets (Sylenth, Spire and Massive) used to create all the melodic elements of chords, pads, plucks, bass! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. For Synth presets you will need Sylenth 3.0.3 & Spire 1.1.12, Massive v1.4 or higher is required) Pack Content: 5xConstruxction Kits 50xDry Loops of Bass and Melodies (Plucks, Chords, Piano, Bass, Synths) 50xWet Loops of Bass and Melodies (Plucks, Chords, Piano, Bass, Synths) 29xDrum Hits 33xFxs 42xMidi Files 21xSpire Presets 5xSylenth Presets 5xMassive Presets

HighLife Samples returns to where it all began and where many of you felt your first heart-beat skip! Trance is one of the oldest most loved EDM genres, and HighLife delivers the sounds that have become the staple in today's Trance scene! HighLife Samples Power Trance This pack offers the greatest tools and source of inspiration you have been missing! You will find 5 complete construction kits for your musical needs. All kits include both dry and wet Bass and Melody loops, Chords, Leads, Plucks and Acids, Vocal chops, FXs including uplifters, downlifters, impacts, sweeps and noise, and of course all Drum Hits and Drum loops. We have included all Instrumental Loops in midi form as well as wav for your own convenience and creative freedom. We also give away all presets (Sylenth and Spire) used to create our unique sounds! What's more, everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. Pack Content: • 5 x Construction Kits • 26 x Drum Loops • 53 x Dry Loops of Bass and Melodies • 53 x Wet Loops of Bass and Melodies • 23 x Drum Hits • 42 x Fx’s • 29 x Midi Files • 19 x Spire Presets • 10 x Sylenth Presets • 2 x Dry Vocal Loops • 2 x Wet Vocal Loops

Big Sounds is back with another top notch pack. Inspired from the world leading djs and festival arenas. This pack has just what you need you definitely don’t want to miss! Big Sounds EDM: Big Stage Festival. In it you will find 5 complete construction kits, offering the greatest tools and source of inspiration you have been missing. All kits include breakdowns, drops leads, Bass loops, Melodies, Chords, Leads, Plucks and FX, including mixed Fxs of, impacts and noise, Risers, Uplifters.Downlifters and of course all Drum loops. With each kit you get the wav files, midis and the Sylenth1 presets used to create our distinctive sounds! As a bonus we have included a folders of Drum Hits, from kicks and snares to claps and hi hats, toms PLUS a folder of Fxs of impacts, Risers, Uplifters & Downlifters. Everything you get is Royalty Free! Buy once and use in any of your projects in as many combinations as you want. Compatible with all DAWs and usable in more projects and genres than you can imagine. For synth presets is required Sylenth 3.0.3 Pack Content: • 5 x Construction Kits • 18 x Midi Files • 17 x Sylenth 1 Preset’s • 24 x Synth Loops (Chords, Drop Leads, Bass, Plucks) • 3 x Vocal Chop Loops • 20 x Drum Hits of Snares • 31 x Drum Loops • 20 x Drum Hits of Toms • 40 x Fx’s (Uplifters, Downlifters, Risers, Impacts) • 20 x Drum Hits of Kicks • 20 x Drum Hits of Hi-Hats

This is a special episode as it marks the 2nd anniversary of Loud Pipes!  Also this date is import in American history as it marks the 15th anniversary since 9/11, so the guys take a moment to remember all the lives lost on this day.Tonight the guys are going to give updates on past guest that have been on the show as well as some special guests calling into the show.Smith from Mortons custom cycleAlex Crookes from EatSleepRIDE - No major update on app, but they are heading to the "Tail of the Dragon"Lee Conn from MotusRecent appearance on Jay Leno's garageRichard Janis MotorcyclesDiscovery days coming up in SeptemberLooking forward to seeing them at Barber againNeville Lee 2 wheels 1 causeMatthew WilliamsNo major moto vlogging update.  He has fixed the Manga from issues on June mountain ride. Jim May - Mathews Fun MachinesFlying Fortress is in and they have a demo bike, stop by and take it for a rideCharlie Hearn - Motorcycle of CharlotteBMW has a Scrambler coming out soonBMW has a 310R coming out soonTriumph is talking about redoing the Street Triple to an 800 modelUral has a new special edition. The Gear Up SaharaZero had two new bikes release this year - DSR and FXS.  They also have a 10th Anniversary DSR.  There is talk that a redesign of bikes for 2018.MV Agusta updated their Brutale 800 this yearMorgan three wheelers announced an EV Model.  As will be bringing 4 wheel cars to America, but no date yet.Events:The Distinguished Gentleman's Ride - September 25th.  This event was started in 2012 and in 2015 the ride had over 37,000 participants in 410 cities in 79 countries which raised over $2.3M (US) for prostate cancer research.Indian Motorcycles in Gastonia is now hosting a Bikes, Cars, and Coffee on Saturday.  The first event was September 3rd.Deb Gasque (The Fashionista has an iron butt) - Joined the guys for the showWill be doing the 50CC at the end of September, leaving from Jacksonville, FL and riding to San Diego, CA in 50 hours.After completing the 50CC will take back road back to east coast and stop at Barber to visit with the guys.Kevin McKinney from Throttled PodcastAlso attending Barber and will meet up with the guysOne year anniversary show will be in a couple of weeksTed Ketler from Motorcycle Men Podcast - Called into the showAerin Shaw from Dr. Jekill and Mr. HydeRobert Rivera airbrush artistJocelyn Dorsey WBTV-2Roundtable Aaron Smith, road hogs, and vloggersEVENTSUpcoming events that one or more Loud Pipes! members plan to attend: 2017 Harley Milwaukee Eight demo rides.  September 17th and 18th (pre-open house event, no-sign up and will be first come first serve)12th Annual Barber Vintage Festival (October 7th-9th, 2016)   PATRON UPDATEWe are working on a new support level called the "Barber Shop" to coincide with our 2nd annual trip to the Barber Vintage Festival.  As of now we have set the support level at $10/month with a new logo t-shirt and some sort of annual Loud Pipes! swag.Help keep the show AD free and receive rewards for your contribution by visiting loudpipes.net/donate.  Patreon is our focus and is an ongoing support model.  There is also a link for one time donations and support of any size is greatly appreciated.Running time: 1 hour 11 minutes 05 secondsQuestions or comments: feedback@rdubstudios.com or the Feedback page

Wild City #090 comes from Karachi based electronic producer TMPST – a genre bending artist who’s been at the forefront of the Pakistani scene for some time. With the third edition of the (Pakistan focused) Border Movement Lounge in India taking place tonight at the Max Mueller Bhavan, we thought it’s about time that we featured another exclusive, carefully curated mixtape from our contemporaries in the west. Asfandyar Khan is the man behind the 2-step, garage inspired beats and synths of TMPST as well as a range of downtempo, often hauntingly composed ambient music he records under his own name. He’s been making music since 2010 and equipped with nothing other than a guitar, released his first album, titled ‘Snow Makes Things Perfect’. The musician’s affinity for bass and beat only became apparent in 2012 with the birth of his ‘post-dubstep’ and garage inspired outfit TMPST. Despite TMPST’s foray into the world of bass however, he never quite manages to let go of the ambient sounds that began his journey and that peculiar seepage is what makes his sound to interesting. His last EP ‘Serpentine’ sees garage influenced choppy female vocals combined with undulating, atmospheric basslines and deep, dub wubs cleverly juxtaposed against drawling, emotive synths. TMPST’s exclusive Wild City Mix begins with an original ambient track by Asfandyar Khan. Apart from some excellent tunes by the likes of Lapalux and DEFT, this mix also features a bunch of music from the region. That includes some unreleased sounds by Asfandyar’s FXS peers, including a particularly impressive, unnamed mix closer from its founder Dynoman. Mix #090 starts on a placid note and ends on a high, occupies a comfortable space between your headphones and the dancefloor. It’s made of versatile stuff. For a tracklist and further info, head over here: http://www.thewildcity.com/EN/music.xhtml/article/7820-wild-city-090-tmpst

The week we go insane breaking down season one of FX's The Strain and answer some pressing questions like, who is The Master? Who are those Vampire SWAT guys and what happens next with our very own Strain expert Brian. We also discuss The Marvel Comics reboot in 2015, the new Secret Wars and the season opener of Arrow and The Flash. 

Andrés Romario Manzano Rubio (Andruss), productor desde los 16 años junto con Jesús Gorocica Lopez (Jesser, Produciendo actualmente). Comenzando con generos como: French House, Electro y Experimental. en 2007 profesionalizan sus producciones ya con el "Trance" como gusto propio y lanzando Eps con diferentes disqueras: Magenta Recordings, Istmo Music (Dub Tech Rec. entre otras. En el 2009 comienza como Dj de la Escena Tech House y Electro, tocando en diferentes lugares como: La Santa, Casa Pompidou, Delorean Bar, entre otros Mezclando lo más fresco y bailable de la música haciendo mashups en vivo para prender a cualquiera, llevando a otro nivel y prender el Dancefloor. Actualmente trabaja en proyectos alterno al "Trance", creando sonidos French, Acid y Fxs,para así darle algo fresco y con estilo a la Escena Electrónica. Andruss (Dubstard), proyecto alterno de producciones y remixes para escenas nacionales del Dubstep, Electro & Trap. Andruss a recibido apoyo de Dj/Producers nacionales:HNBK, Dirty Ganesh, Andy Woldman e Internacionales como: Dash Berlin, Rank 1, Indecent Noise por mencionar algunos. Sello discográficos:|Get It On Records|Istmo Music|Magenta Rec.|Cloudland Music|Abstract Music| sus paginas oficiales: https://www.facebook.com/AndrussOfficial https://www.soundcloud.com/Andruss https://www.mixcloud.com/Andruss https://www.youtube.com/AndrussMusicOfficial https://www.twitter.com/AndrussMusic Contacto/Boking: andrussmusic@hotmail.com

David Cunningham Owens is Professor of Clinical Psychiatry at the University of Edinburgh and honorary consultant psychiatrist, the Royal Edinburgh Hospital. This talk revealed how the development of neuronal communication at synapses is altered in Fragile X Syndrome (FXS). It also examines how basic research into the role of genetics has led to the development of new medicines for treating FXS and hopefully will result in treatment possibilities for some forms of autism. This lecture is part of the Medical Detectives, a series of public lectures that show how keen detective work is still essential for 21st century doctors: http://www.ed.ac.uk/news/events/medical-detectives/ Recorded on 20 September 2012 in the Anatomy Lecture Theatre at the University of Edinburgh.

Professor Peter Kind is Professor of Developmental Neuroscience at the Centre for Integrative Physiology, the University of Edinburgh. Normal brain development depends upon brain cells (neurones) talking to each other at specialised sites called synapses. Disorders that affect this communication process include Fragile X Syndrome and Autism Spectrum Disorder. This talk will reveal how the development of neuronal communication at synapses is altered in Fragile X Syndrome (FXS). We will also examine how basic research into the role of genetics has led to the development of new medicines for treating FXS and hopefully will result in treatment possibilities for some forms of autism. This lecture is part of the Medical Detectives, a series of public lectures that show how keen detective work is still essential for 21st century doctors: http://www.ed.ac.uk/news/events/medical-detectives/ Recorded on Thursday 20 October 2011 in the Anatomy Lecture Theatre at the University of Edinburgh.

Join us as we speak with Vicki Sudhalter, PhD, about Individualized Education Plans. The Individualized Education Plan (IEP) is a very influential document in the academic life of any child with special needs. In this session we will discuss how to help create an IEP which addresses and helps to ameliorate behavioral challenges confronting children with fragile X syndrome (FXS). This presentation will address the importance of a child's IEP and the IEP writing and approval process, with an emphasis on the importance of including accommodations for hyperarousal as part of the IEP for any child with FXS.

Thatswecalltechno006-Vector Commander by Thatswecalltechno Podcast on MixcloudTracklist:1- Binary Code2- True Spirit3- 2 Mil Leagues Submarines4- Motherchip5- Ruins Of Society6- Dark Vader7- Space Cruiser8- Amnesia9- Ming F-2510-Deep Space11-Submarine12-Technological Impact13-Industrialaser14-Android15-Assimetric16-Movement17-High 818-Scanners19-El Diablo110:50 minutesAll tracks Created by Alex Strunz (Vector Commander) Analog Machines, Fxs, and voices of Alex StrunzDownload

We speak with the Foundation's Support Services Coordinator Jayne Dixon Weber about her holiday experiences with her FXS-diagnosed son Ian. She gives a few tips on how to deal with the holidays, which can also be applied to other situations. You can reach Jayne Dixon Weber at treatment@fragilex.org

Supplementary Materials:PDF of Powerpoint Presentation (download) This presentation is designed to give participants the skills and confidence to present the topic of FXS to their child’s classmates. Reaching out to students is a great way to provide a personal understanding of Fragile X along with facts about what is Fragile X. This understanding of fragile x and disabilities in general will help foster friendships and compassion. Holly Roos is the mother of 2 children, Parker & Allison both affected by Fragile X Syndrome. She is the founder and president of the Central IL Fragile X Resource Group and Board member of Advocates for Access in Peoria Heights, Illinois. In 2007 Holly was the winner of WEEK's 25 women in Leadership for her work in Fragile X. The National Fragile X Foundation recognized Holly’s outstanding contributions to the FX Community with the Education and Awareness Award at the 11th International Fragile X Conference.

Supplementary MaterialPDF of Powerpoint Presentation (download) Learn about Sensory Integration with Tracy Stackhouse, MA, OTR, and Sarah “Mouse” Scharfenaker, MA, CCC-SLP. They are co-founders and directors of Developmental Fragile X Resource Center in Denver, Colorado.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.21.053652v1?rss=1 Authors: Guthman, E. M., Svalina, M. N., Cea-Del Rio, C. A., Kushner, J. K., Baca, S. M., Restrepo, D., Huntsman, M. M. Abstract: Fragile X Syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, autism spectrum disorders (ASDs), and anxiety disorders. The disruption in the function of the FMR1 gene results in a range of alterations in cellular and synaptic function. Previous studies have identified dynamic alterations in inhibitory neurotransmission in early postnatal development in the amygdala of the mouse model of FXS. Yet little is known how these changes alter microcircuit development and plasticity in the lateral amygdala (LA). Using whole-cell patch clamp electrophysiology, we demonstrate that principal neurons (PNs) in the LA exhibit hyperexcitability with a concomitant increase in the synaptic strength of excitatory synapses in the BLA. Further, reduced feed-forward inhibition appears to enhance synaptic plasticity in the FXS amygdala. These results demonstrate that plasticity is enhanced in the amygdala of the juvenile Fmr1 KO mouse and that E/I imbalance may underpin anxiety disorders commonly seen in FXS and ASDs. Copy rights belong to original authors. Visit the link for more info