Podcasts about cyp1a2

Coffee is the most consumed beverage on the planet—second only to water. But here's the catch: depending on how (and what) you drink, your morning cup could either boost your brain, metabolism, and longevity… or quietly wreck your gut, hormones, and sleep. In this powerhouse episode of The Dr. Josh Axe Show, Dr. Axe reveals the shocking truths about coffee—what mainstream health advice often gets wrong, how your genes impact your reaction to caffeine, and why choosing the right kind of coffee matters more than you think. Whether you're a lifelong coffee lover or just curious about its health effects, this episode is your ultimate guide to doing coffee the right way. What You'll Learn: Why coffee doesn't actually give you energy—and what it's really doing to your brain How your genetics (including the CYP1A2 gene) determine whether coffee is your medicine or your enemy The critical link between coffee, gut health, adrenal fatigue, and hormone imbalance The top 3 toxins lurking in most commercial coffee—and how to avoid them Why your timing matters: when to drink coffee for peak performance (and when to avoid it completely) The truth about mold, acidity, and how to choose coffee that heals, not harms The best alternatives to traditional coffee—including matcha, mushroom coffee, and herbal substitutes. You'll walk away knowing exactly how to personalize your coffee habits for better energy, sharper focus, and longer-lasting health. Plus, Dr. Axe sits down with coffee expert and Lifeboost founder Dr. Charles Livingston to uncover how the cleanest coffee in the world is made—and what to look for on the label to protect your body. If you drink coffee, this episode could change your health forever. Don't miss it. #coffee #draxe #drjoshaxe Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get: Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://www.ncausa.org/newsroom/nca-releases-atlas-of-american-coffee https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800839 https://pmc.ncbi.nlm.nih.gov/articles/PMC5445139/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2257922/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10262944 https://pmc.ncbi.nlm.nih.gov/articles/PMC9227174/ https://www.j-alz.com/content/coffee-consumption-habits-impact-risk-mild-cognitive-impairment-italian-longitudinal-study https://pmc.ncbi.nlm.nih.gov/articles/PMC10891742/ https://pubmed.ncbi.nlm.nih.gov/38802651/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/ https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.13065 https://pubmed.ncbi.nlm.nih.gov/38802651/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8778943/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2257922/ https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1188547/full https://pubmed.ncbi.nlm.nih.gov/18606630/ https://pubmed.ncbi.nlm.nih.gov/34538097/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9681499/ https://www.sciencedirect.com/science/article/abs/pii/S0278691515300831 https://www.sleepfoundation.org/nutrition/caffeine-and-sleep https://pmc.ncbi.nlm.nih.gov/articles/PMC7222172/ http://lifeboostcoffee.com/AXE ------  Ads:  Visit lifeboostcoffee.com/AXE, and as a first-time customer, enjoy a massive 58% discount on your first order.

Contributor: Jorge Chalit-Hernandez, OMS3 Educational Pearls: CYP enzymes are responsible for the metabolism of many medications, drugs, and other substances CYP3A4 is responsible for the majority Other common ones include CYP2D6 (antidepressants), CYP2E1 (alcohol), and CYP1A2 (cigarettes) CYP inducers lead to reduced concentrations of a particular medication CYP inhibitors effectively increase concentrations of certain medications in the body Examples of CYP inducers Phenobarbital Rifampin  Cigarettes St. John's Wort Examples of CYP inhibitors -azole antifungals like itraconazole and ketoconazole Bactrim (trimethoprim-sulfamethoxazole) Ritonavir (found in Paxlovid) Grapefruit juice Clinical relevance Drug-drug interactions happen frequently and often go unrecognized or underrecognized in patients with significant polypharmacy A study conducted on patients receiving Bactrim and other antibiotics found increased rates of anticoagulation in patients receiving Bactrim Currently, Paxlovid is prescribed to patients with COVID-19, many of whom have multiple comorbidities and are on multiple medications Paxlovid contains ritonavir, a powerful CYP inhibitor that can increase concentrations of many other medications A complete list of clinically relevant CYP inhibitors can be found on the FDA website: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers  References Glasheen JJ, Fugit RV, Prochazka AV. The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. J Gen Intern Med. 2005;20(7):653-656. doi:10.1111/j.1525-1497.2005.0136.x Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007;76(3):391-396. PAXLOVID™. Drug interactions. PAXLOVIDHCP. Accessed March 16, 2025. https://www.paxlovidhcp.com/drug-interactions Summarized & Edited by Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

In this episode of Daily Value, we look at the relationship between genetics, habitual caffeine intake, and cognitive performance, using insights from a recent study (PMID: 39648354) in the Journal of Psychopharmacology. Whether you're a "fast" or "slow" caffeine metabolizer could significantly influence how caffeine impacts your brain.Discussion Points:Gene-Caffeine Interactions: how variants in CYP1A2 and ADORA2A genes modulate caffeine metabolism and sensitivity, leading to differential effects on executive function and social cognition.Cognitive Domains: Why slow metabolizers consuming high caffeine outperform fast metabolizers in emotion recognition tasks, and why moderate caffeine enhances executive function in fast metabolizers.Practical Applications: Tailoring caffeine intake based on genetic predisposition to optimize focus, decision-making, and cognitive flexibility.https://pubmed.ncbi.nlm.nih.gov/39648354/Support the show

VROOM VROOM, BABY! Caffeine is THE most widely consumed psychoactive substance in the world, and it's one of the most commonly available ergogenic aids (i.e. substances that can improve athletic performance). In this episode we talk about the research behind caffeine and its effect on endurance performance, "fast" and "slow" metabolizers, dosing, timing, the placebo effect, caffeine's effect on heart rate, and more! Coach Elisabeth is the Founder and Head Coach at Running Explained, 6x marathoner, multi-certified coach, Boston Qualifier, and enthusiastic believer in your ability to turn the impossible into the possible. Whether you're a brand new runner or have been pounding the pavement for decades, she believes there is always more to learn about running and always more that running can teach us about life. C⁠⁠⁠⁠⁠rush your goals with a Running Explained training plan, masterclass, group coaching, or 1:1 coaching⁠⁠⁠⁠⁠, or learn from her meticulously researched ⁠⁠⁠⁠⁠Instagram posts on a wide variety of running-related topics⁠⁠⁠⁠⁠! References: Bangsbo, J., Jacobsen, K., Nordberg, N., Christensen, N. J., & Graham, T. (1992). Acute and habitual caffeine ingestion and metabolic responses to steady-state exercise. Journal of applied physiology (Bethesda, Md. : 1985), 72(4), 1297–1303. https://doi.org/10.1152/jappl.1992.72.4.1297 Barreto, G., Grecco, B., Merola, P., Reis, C. E. G., Gualano, B., & Saunders, B. (2021). Novel insights on caffeine supplementation, CYP1A2 genotype, physiological responses and exercise performance. European journal of applied physiology, 121(3), 749–769. https://doi.org/10.1007/s00421-020-04571-7 Beedie, C. J., Stuart, E. M., Coleman, D. A., & Foad, A. J. (2006). Placebo effects of caffeine on cycling performance. Medicine and science in sports and exercise, 38(12), 2159–2164. https://doi.org/10.1249/01.mss.0000233805.56315.a9 Collado-Mateo D, Lavín-Pérez AM, Merellano-Navarro E, Coso JD. Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis. Nutrients. 2020 Nov 24;12(12):3603. doi: 10.3390/nu12123603. PMID: 33255240; PMCID: PMC7760526. Glaister, M., Williams, B. H., Muniz-Pumares, D., Balsalobre-Fernández, C., & Foley, P. (2016). The Effects of Caffeine Supplementation on Physiological Responses to Submaximal Exercise in Endurance-Trained Men. PloS one, 11(8), e0161375. https://doi.org/10.1371/journal.pone.0161375 Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4 McClaran SR, Wetter TJ. Low doses of caffeine reduce heart rate during submaximal cycle ergometry. J Int Soc Sports Nutr. 2007 Oct 9;4:11. doi: 10.1186/1550-2783-4-11. PMID: 17925021; PMCID: PMC2164943.

In this week's episode we talk to researcher Dr. Bryan Saunders aboutHow caffeine affects the bodyHow genetics plays a role in your ability to metabolize caffeineCommon questions about using caffeine to improve performanceDr. Bryan Saunders is currently a researcher and lecturer at the Faculty of Medicine of the University of São Paulo in Brazil. He has also worked as an exercise physiologist for the São Paulo Cycling Federation, as well as a lecturer at the Poznań University of Physical Education in Poland. He completed his post-doctoral research at School of Physical Education and Sport at  University of São Paulo after completing his undergrad, master's and PhD in the UK. He is actively involved in researching sports nutrition, nutritional supplementation, exercise physiology and performance, as well as applied physiology and nutrition and placebo and nocebo effects.Please note that this podcast is created strictly for educational purposes and should never be used for medical diagnosis and treatment.***Keep up with Bryan Saunders:X: https://twitter.com/Bicycle_BryanBryan's Research: https://www.researchgate.net/profile/Bryan-Saunders-2More Reading:Novel insights on caffeine supplementation, CYP1A2 genotype, physiological responses and exercise performance: https://link.springer.com/article/10.1007/s00421-020-04571-7Placebo in sports nutrition: A proof of principle study involving caffeine supplementation: https://www.researchgate.net/publication/310790017_Placebo_in_sports_nutrition_A_proof-of-principle_study_involving_caffeine_supplementationCaffeine and Sports Performance, Louise Burke: https://www.researchgate.net/publication/23669680_Caffeine_and_sport_performanceCaffeine withdrawal and high-intensity endurance cycling performance: https://scholar.google.com.au/citations?view_op=view_citation&hl=en&user=4EW4oocAAAAJ&citation_for_view=4EW4oocAAAAJ:eQOLeE2rZwMC Mentioned:Hypohydration, Lewis James: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492205/MORE NR New customers save 10% off all products on our website with the code NEWPOD10 If you would like to work with our practitioners, click here: https://nutritional-revolution.com/work-with-us/ Save 20% on all supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off right away with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution Interested in blood testing? Use code NUTRITIONALREVOLUTION at InsideTracker for 20% off any test: store.insidetracker.com/nutritionalrevolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

Links Mentioned in the Episode:Muzykiewicz-Szymańska, A., Nowak, A., Wira, D., & Klimowicz, A. (2021). The Effect of Brewing Process Parameters on Antioxidant Activity and Caffeine Content in Infusions of Roasted and Unroasted Arabica Coffee Beans Originated from Different Countries. Molecules (Basel, Switzerland), 26(12), 3681. https://doi.org/10.3390/molecules26123681www.betterwithcarbo.com/guideIntroduction:Hello, hello! Happy Tuesday, and welcome back to another episode of the Inflamed in the Brain podcast. I'm your host, Krissy, and today's episode is a special one because we're diving deep into the world of coffee. I have a personal love affair with this magical brew—it's an integral part of my morning ritual, shared with my partner Arthur. Many significant conversations about life and goals have unfolded over a cup of coffee, making this episode particularly sentimental. So, grab your favorite brew, and let's explore the anti-inflammatory benefits coffee brings to the table.Understanding Free Radicals:Before we savor the aromatic details of coffee, let's unravel the mystery of free radicals and oxidative stress. Picture free radicals as trouble-making molecules in our bodies, seeking electrons from other molecules, making them unstable. These troublemakers enter our bodies through environmental factors like air pollutants, cigarette smoke, and more. The danger lies in their potential to cause cellular damage, contributing to inflammation, premature cell death, and diseases like hypertension, arthritis, and certain cancers.Main Points:Antioxidant Content of Coffee:Coffee, a true ally for fellow coffee lovers, boasts antioxidants like chlorogenic acids (CGAs), polyphenols, and flavonoids.Brewing methods and bean types influence antioxidant activity. Roasted beans in hot brews exhibit higher antioxidative properties, with origins impacting radical scavenging abilities.Incorporating coffee into your morning routine significantly enhances anti-inflammatory efforts, promoting a healthier you.Coffee's Impact on Inflammatory Markers:Antioxidants and polyphenols in coffee lower inflammatory markers like C-reactive protein (CRP).CGAs in coffee neutralize free radicals, reducing inflammation. Additionally, polyphenols inhibit pathways leading to inflammatory marker production.Coffee's CGAs help decrease the activity of nuclear factor-kappa B (NF-κB), a transcription factor responsible for expressing proinflammatory genes.Coffee's Impact on Gut Health:Coffee acts as a prebiotic, supporting beneficial bacteria in the gut. Chlorogenic acids break down into ferulic acid and caffeic acid, nurturing a healthy gut microbiome.Supporting your gut health with coffee contributes to a robust immune system and a fortified gastrointestinal barrier, preventing inflammation and leaky gut.How Much Coffee Should You Have:The FDA recommends up to 400 milligrams of caffeine, roughly four cups of coffee, as generally safe.Be mindful of your caffeine intake, considering factors like anxiety, sleep issues, and high blood pressure. Genetic variations, like those in the CYP1A2 gene, can influence how your body responds to coffee.Healthy Ways to Enjoy Coffee:Mindfully sweeten your coffee, avoiding excessive sugars that contribute to inflammation.Experiment with alternative sweeteners or enjoy your coffee with cream, milk, or oat milk for a naturally sweet touch.Consider the origin and cultivation methods ofFollow along: https://betterwithcarbo.com/ Instagram

As someone who's always had trouble focusing, Jack Savage was prescribed stimulants at the age of 5 until high blood pressure gave cause for serious concern. He quit cold turkey and started drinking lots of coffee. After 1-2 hours of ineffective energy, he'd crash or if he drank too much, he'd feel jittery and anxious. That's when he started researching biohacking, nutrition and functional mushrooms. Jack found that basically all mushrooms are magical, especially when combined with nootropics. This led him to the ingredients in Everyday Dose, which have allowed him to regain control of his life for the first time. It became his mission to help others also transform their lives by making everyday products healthier and upgrading the way we energize. In this episode Jack tells his story about how we went stimulants-free, how Ketamine works and how he created his coffee to be different from the rest.  Learn more about Everyday Dose here and use coupon code COACHTARA to get a special deal when purchasing mushroom products: https://www.everydaydose.com/COACHTARA Instagram: @everydaydose  IN THIS EPISODE YOU WILL DISCOVER: 00:03:18 - why Jack started Everyday Dose 00:10:00 - Jack explains what Ketamine does  00:13:00 - why Everyday Dose coffee is different  00:18:50 - what L-Theanine is good for 00:22:00 - the difference between fast metabolizer of caffeine and slow metabolizer 00:28:20 - what if you have a slow CYP1A2 gene 00:33:45 - mineral deficiency 00:38:50 - how Jack loves to make his coffee  

This week on ReInvent Healthcare, I emphasize the importance of understanding certain genetic variants and their impact on detoxification pathways. As well as certain tests you can suggest to your clients and foods that can help their detoxification pathways so they live a balanced lifestyle.IN THIS EPISODE:Defining Detoxification PathwaysDetoxification is a critical function, especially in today's world filled with environmental toxins, pesticides, and pollutants. The liver plays a crucial role in detoxification, and there are two phases of detoxification - Phase 1 and Phase 2. Understanding genetic SNPs (single nucleotide polymorphisms) and their role in the body's detox pathways give us valuable insights into individual variations and susceptibilities.Some Detoxification SNPs - There are several genetic SNPs related to detoxification pathways, such as CYP1A1, CYP1A2, CYP1B1, CYP3A4, CYP2C9, and others. These SNPs influence the detoxification of environmental toxins, caffeine, estrogen, prescription drugs, aflatoxin, and more. Understanding these SNPs allows us to identify potential imbalances in detox pathways and helps us make informed decisions for personalized wellness strategies.Importance of TestingTesting is essential to determine whether the detoxification SNPs are active and causing imbalances in the detox pathways. Organic acid tests and blood tests, such as liver function tests and methylation markers, can help identify potential issues. By combining genetic information with lab testing, we gain a comprehensive view of a person's detoxification capabilities. Understanding genetic SNPs and lab results helps us guide patients toward avoiding toxic exposures, environmental pollutants, and food additives that may burden their detox pathways.How To Support DetoxificationOnce genetic SNPs and active detox pathways are identified, our clients can be educated on avoiding toxic substances and making lifestyle changes. These changes may include using non-toxic household products, choosing organic food, avoiding food additives, and reducing exposure to common allergens. Additionally, incorporating certain detox-supporting herbs like artichoke leaf, burdock root, dandelion, and Hawthorn berry can be beneficial.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training. Check out our other episodes about Functional Food Facts here.

This week on ReInvent Healthcare, I bring back a talk I had about caffeine and estrogen. For those who have so many clients who are addicted to caffeine and are unwilling to lessen their caffeine intake, you can show them why it's important, by explaining this caffeine's effects on the estrogen metabolism and the inherent risks. Listen to the full episode to find out more.IN THIS EPISODE:Caffeine and Breast CancerCaffeine's effect on the body revolves around the enzyme CYP1A2 and its implications on breast cancer risk. The enzyme's had a significant role in detoxifying caffeine, accounting for approximately 90-95% of its clearance. Constant caffeine exposure may divert CYP1A2 from its detoxification function in estrogen metabolism to detecting caffeine, resulting in reduced capacity to detoxify and eliminate toxic estrogen metabolites. This diversion potentially leads to estrogen dominance, which can disrupt hormonal balance and increase the risk of breast and other hormone related cancers.Genetic variations in the CYP1A2 gene influence caffeine and estrogen metabolism. Individuals with specific genetic profiles may exhibit altered caffeine and estrogen metabolism, warranting a personalized approach in managing caffeine consumption and lifestyle choices. For individuals with genetic variations, caffeine should be reduced or eliminated to minimize potential health risks associated with estrogen imbalance and breast cancer.Caffeine's Effect on EstrogenProlonged caffeine exposure diverts CYP1A2 from its primary role in metabolizing estrogens, potentially leading to estrogen dominance, hormonal imbalances, and related health concerns. The intricate interplay between caffeine and estrogen levels underscores the importance of personalized lifestyle choices, particularly for individuals with specific genetic variations in the CYP1A2 gene.Chronic caffeine consumption is also linked to increased blood sugar levels, insomnia, acid reflux, and alterations in cortisol production, all of which can disrupt estrogen and progesterone balance. Surprisingly, caffeine's potential cross-reactivity with gluten potentially impacts susceptible individuals and further complicates estrogen-related health outcomes. The Gut Microbiome and EstrogenCertain bacteria in the gut are capable of metabolizing estrogen, specifically by producing an enzyme called β-glucuronidase. This enzyme has the ability to break down estrogen conjugates, which are inactive forms of estrogen, into active and bioavailable estrogen.The activity of β-glucuronidase can lead to increased levels of estrogen in the body, as the breakdown of conjugated estrogen allows for its reabsorption into circulation. This can potentially impact hormone balance and contribute to various estrogen-related conditions.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training. Watch the video version with charts and graphics here.

Diese Episode findest du auch im Videoformat unter www.epi-genes.com. Lutz Graumann ist Arzt für Sportmedizin, Ernährungsmedizin und Chirotherapie mit Fokus auf Leistungssteigerung. Er ist Direktor für Performance Medizin bei Tignum, Gründer von Sportmedizin Rosenheim und Quest Vitality und Teamarzt beim Deutschen Eishockeybund. Lutz gibt Ausbildungen in Functional und Fascial Training bei Blackroll und ist bestselling Autor mehrer Bücher. Sein Schwerpunkt liegt in der Förderung der individuellen Leistungsfähigkeit. Er integriert Sport- und Militärmedizin mit neuen Technologien, um datenbasierte personalisierte Bewegungs-, Ernährungs-, Erholungs- und Mindset-Strategien für den Spitzensport, für Spezialeinheiten und Kampfpiloten als auch für High-Performer aus der Wirtschaft und dem realen Leben zu entwickeln.   Lutz und ich kennen uns schon seit ca. 10 Jahren und ich fand seine Arbeit schon immer total begeisternd. Deshalb freute ich mich ganz besonders auf das Interview mit ihm und darüber seine Expertise zum Thema Schlaf und HRV zu teilen.  Inhalte: 4:35 min: Einstieg Schlaf, Eishockey Nationalmannschaft & WM  7:32 min: Schlafqualität von Athleten & Chronotypen 9:32 min: Dr. Michale Breus Chronotypen (Buch: The Power of when) und epigenetische Strategien 12:17 min: Melatonin, Koffein, Dosierung, B-Vitamine, Koffeinstoffwechsel, CYP1A2 14:32 min: Biohacking, Klangwelten, Bineurale Beats & Schlaf 17:32 min: HRV, autonomes Nervensystem & Flow 22:32 min: unterschiedliche HRV Marker & Atemfrequenz 24:12 min: HRV Messungen 28:17 min: Chest Strap, Ring, Validität & Trends 29:02 min: optische Signalgeber und Messmethode von Fitnesstracker und HRV Tracker 32:02 min: rmssd Messung, Maximilian Mooser und Algorithmen  39:21 min: High Frequency/Low Frequency Power Domäne 44:02 min: welche Messmethoden für wen? 47:42 min: HRV & Schwankungsbreiten 49:38 min: HRV & Schlaf  55:02 min: REM und Tiefschlafphasen 59:32 min: Lutzs Empfehlungen zur Optimierung der Schlafqualität 1:01:02 min: Nährstoffe und Pflanzenstoffe für den Schlaf  1:04:22 min: Das Phänomen Traum   Links: Sportmedizin Rosenheim: https://sportmedizin-rosenheim.de/ Bittium HRV Messung: https://www.bittium.com/medical/bittium-faros Buch Endlich richtig ausgeschlafen Vitality Sounds app oura.com Melatonin

For anyone looking to ignite their fat-burning metabolism, boost their energy, and transform how they look and feel, they must start taking care of their liver. Your liver is your body's master detoxifier. It performs over 500 key functions in your body every single day. After decades of wear and tear, our livers slow down and become sluggish. Fortunately, there's a simple, all-natural solution that I recommend. It's called Liver Health Formula. Liver Health Formula contains 12 powerful botanicals clinically proven to recharge and protect your liver at the cellular level. It helps restore your liver's detoxifying abilities. Try Liver Health Formula completely risk-free, and receive 5 FREE gifts when you order today. Just go to GetLiverHelp.com/Jockers to claim your risk-free supply of Liver Health Formula and all 5 bonus gifts.   Today's episode is proudly sponsored by Paleovalley Organic Supergreens, a delicious blend of 23 organic superfoods to energize your body! Paleovalley Organic Supergreens uses only the finest, most bioavailable superfoods helping your body absorb those valuable vitamins, minerals, antioxidants, and enzymes found in each delicious serving. Paleovalley Organic Supergreens is a certified organic, gut-friendly, and nutrient-rich drink you and your kids are sure to love! Hurry and grab yours from Paleovalley.com and be sure to use code JOCKERS at checkout for an extra 15% off!   Are your joints painful? Do you suffer from daily discomfort? As it stands today, chronic pain affects more Americans than DIABETES, HEART DISEASE, and CANCER combined.   In fact, chronic pain is THE NUMBER ONE reason Americans access the Healthcare system today. However, many people believe their only option for pain relief is found in drugstore options such as Ibuprofen, Advil, and Tylenol (to name a few). Tragically, most people are unaware that these pain meds do more HARM than good. Common side effects include Headaches, Liver and Kidney issues, High Blood Pressure, and in rare cases – even death. Not to mention, they are just masking your pain... Giving you temporary relief...   While this may sound all doom and gloom, I do have good news... There is an all-natural solution that addresses the root cause of your discomfort... A REAL solution that allows you to get back to being YOU!   And that solution is called Curcumin Gold made by my friends at Purality Health. Curcumin Gold contains Turmeric Curcumin Extract, Vegan Omega-3s, & Ginger Oil. These carefully selected ingredients support healthy joint function and address the root cause of inflammation within your body. Trust me when I say you won't find anything else on the market quite like this. In fact, my friends over at Purality Health have a patented formula that utilizes something called ‘MICELLE LIPOSOMAL' technology which delivers the nutrients into your bloodstream – proven to be 800% more efficient!   Even better, it's backed by a 180-day money-back guarantee. And today, we have a 30% OFF coupon for you! Visit puralityhealth.com and use the coupon "DRJ" to access 30% OFF today! Are you ready to increase your energy in the morning for increased mental clarity and vitality?  Get a great start to your day, without caffeine, using these five powerful strategies from Dr. Jockers that all work on a cellular level. And there's a bonus sixth tip too! Calming our mitochondria so that we can produce what we need to do on a daily basis, with sustained energy, is the name of the game here. It starts with getting moving and moves on to getting a healthy dose of sunlight (infrared and red light is key).    Exposing yourself to the natural vibrations of the earth (electromagnetic frequency) is next, and there's also cold exposure and hydration to explore as strategies to help quit that (perhaps) unnecessary cup of coffee first thing in the morning. Please join Dr. Jockers and feel alive in the mornings!   “Going out and taking a walk can be one of the most powerful things you do to improve your energy and keep it sustained so you have all day energy throughout the day." -Dr. David Jockers      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   In This Episode: Is Dr. Jockers against caffeine? What is the liver enzyme called CYP1A2 for? Caffeine as an adenosine receptor antagonist — what that means What happens when our mitochondria get hypermetabolic? Get Moving! What are the benefits of moving? The importance of sun exposure What can you do if it's cold or raining?  What does grounding mean? Is cold exposure stressful for your body?  Why does your energy go up after a cold shower? Starting with small doses of cold exposure Dehydrating overnight and then hydrating first thing in the morning  Using a pinch of salt to increase water absorption The importance of a good bowel movement Bonus Tip! Breath holding exercises   Resources: Claim your risk-free supply of Liver Health Formula and all 5 bonus gifts – GetLiverHelp.com/Jockers Paleovalley Organic Supergreens - use code JOCKERS at checkout for an extra 15% off Curcumin Gold -  Visit puralityhealth.com and use coupon "DRJ" to access 30% OFF today!     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ ● If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

Caffeine Dry Scoop: https://youtu.be/sylqJ0NEVJw Happened while filming this video: https://youtu.be/LKNfFm0QDXQ Music by Lifeformed: https://lifeformed.bandcamp.com References: The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A1 Receptor. https://www.mdpi.com/1422-0067/22/1/320 Caffeine Withdrawal. https://www.ncbi.nlm.nih.gov/books/NBK430790/ A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. https://pubmed.ncbi.nlm.nih.gov/15448977/ Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. https://pubmed.ncbi.nlm.nih.gov/20492310/ Coffee, CYP1A2 genotype, and risk of myocardial infarction. https://pubmed.ncbi.nlm.nih.gov/16522833/

Today, I am blessed to have here with me Jack Klauber. He is the Founder and CEO of Everyday Dose, a wellness-forward mushroom latte transforming morning routines. Jack regained control of his life for the first time, and now his mission is to create an accessible wellness program to help others. There are millions of stories like Jack. However, most people haven't yet decided how to break free. Everyday Dose will change that. Check out Everday Dose: https://club.everydaydose.com/ (use code: ketokamp) In this episode, Jack opens the show by revealing the inspiration behind Everyday Dose and how mushrooms have massively improved his health and wellbeing. Then, Jack explains how your coffee jitters could be genetic and why adding Everyday Dose products could be a game-changer for your morning. Everyday Dose combines mushrooms, collagen, and nootropics to activate dopamine, oxytocin, serotonin, and endorphins. Tune in as we chat about the benefits of lion's mane, chaga, and the Everyday Dose products.

Dr. Guillermo Escalante - The Science and Application of Fasted vs. Fed Cardio for Fat LossMy Instagram review of his slidesMy fasted cardio biasesDr. Escalante on IGMona Rosene, MS, RD - NAD, Muscle and Athletic Performance: Current Research and Future Needs sponsored by ChromaDexSupplementsConclusionsDr. Scott Forbes - This Will Blow Your Mind - Creatine and cognitionMore on creatine and cognition on the Flex Diet PodcastDr. Forbes on IGWendy Irlbeck, MS, RDN, LD, CISSN - Practical Applications for Fueling Today's Young AthletesMy takeawayWendy on IGAkihito Nishimura, MS - Citocoline - A Potent Brain Health Nutrient and Nootropic sponsored by Kyowa HakkoIs it beneficial in a healthier population?Is it beneficial in a younger population?Dr. Karen Hecht - Astaxanthin as a Dietary Tool for Exercise Training sponsored by AstraRealWhat it is and what it doesMy thoughtsDr. Helena Yardley - The Science of CannabidiolWhere the industry is headedCBD and pain reliefDosingDr. Kirk Escobar - The Evolutionary Inertia of Weight Loss and Body RecompositionChanges in RMR from the stone ageEfficiencyHow to overcome adaptationKatie Emerson, MS RD - nooLVL - A Non-stimulant Nootropic, sponsored by Nutrition 21Katie on IGDr. Jason Cholewa - Caffeine supplementation: What are the effects of CYP1A2 and ADORA2A genes, paraxanthine, and habitual caffeine consumption on resistance exercise and jumping performanceThe researchParaxanthine as a possible new supplementDr. Jason on IGISSN position stand on caffeineDr. Yala Stevens - The Effects of Citrus  Flavonoids on Exercise Performance: an RCT sponsored by Bio ActorSupplementDr. Mark Willems - Anthocyanin-Rich Supplementation: Potential for Sport and Exercise NutritionNew Zealand Black Current researchDr. Brandon Roberts - The Dose-Response Effects of Arachidonic Acid on Primary Human Skeletal MyoblastsFlex Diet Podcast with Dr. RobertsNSAID researchArachidonic acid as a supplementDr. Roberts on IGDr. Jonathan Mike - I Like Big Recovery and I Cannot Lie: Sports Supplements You Can't DenyDr. Mike on IGDr. Lonnie Lowery - Polyphenols as Potential Ergogenic and Body Composition ModulatorsMore than just caffeineDr. Lowery on IGDr. Adam Gonzalez - Citrulline and Resistance Exercise PerformanceTwo formsVasodilationTakeawayDr. Marcas Bamman - Convergence of Exercise Biology and Machine-Learning to Understand Response HeterogeneityPhysiology is a demand-based systemResponders and non-respondersFor a full list of references, check out the Flex Diet Podcast Episode 157 on my website.The Flex Diet Podcast is brought to you by the Flex Diet Certification. Go to https://flexdiet.com/ for 8 interventions on nutrition and recovery.  If you are outside the enrollment window, sign up for the waitlist and you'll be notified when the course opens again. 

Ropinirole (Requip) is a dopamine agonist that can be used in Parkinson's disease and Restless Legs Syndrome. Dopamine agonists like ropinirole can worsen psychiatric symptoms in some patients by causing hallucinations, and obsessive/compulsive symptoms. Nausea, vomiting, hypotension, and fatigue are the most common adverse effects of ropinirole. Ropinirole has drug interactions with antipsychotics and CYP1A2 inhibitors. I discuss these in greater detail in this podcast episode.

Caffeine: It's likely the most widely used mood- and performance-enhancing drug. However, have you ever noticed that some people are wired all day from one cup of coffee in the morning while others can drink it right before bed? The CYP1A2 enzyme is largely responsible for caffeine metabolism, and our genes may give some information about our individual response. Interested in harnessing the performance-enhancing benefits of caffeine? Mark Goodman, MD, recommends you start by eliminating regular caffeine consumption. Then you can reintroduce a small amount approximately 60 minutes before your workout to observe its effect on your performance.  Experiment with timing and dosage, and keep in mind that some individuals might experience a neutral or even negative effect, so it may take a few trials to find the best formula for you. To learn more about CrossFit Precision Care and how to get involved as a healthcare provider or patient visit care.crossfit.com. If you like this episode, please subscribe to Pursuing Health on iTunes and give it a rating or share your feedback on social media using the hashtag #PursuingHealth. I look forward to bringing you future episodes with inspiring individuals and ideas about health every week. Disclaimer: This podcast is for general information only, and does not provide medical advice.  I recommend that you seek assistance from your personal physician for any health conditions or concerns.

Do you experience jittery hands and light headedness from caffeine? It could be because you are a slow metabolizer of caffeine! How do you know? Getting your genetics tested will tell you directly what your body naturally gravitates toward. Caffeine can be correlated with anxiety and knowing how your CYP1A2 gene along with your COMT gene act, you are able to to tailor your lifestyle accordingly to avoid those side effects. Episode Links and resourcers Personal Instagram, @mrsaprilguilliams: https://bit.ly/3hj9jt1 Podcast Instagram, @betterhealthpodcast: https://bit.ly/3JWAqpX YouTube: https://bit.ly/3hwR7vW Interested in Genetic Testing? Click Here: https://bit.ly/3J1IK7I

Do you experience PMS? Maybe you just want to optimize your hormones? Then listen through this episode. April dives into three specific estrogens and the genes correlated with them. Knowing your genetics rather than guessing, you can then use epigentics (altering lifestyle to modify the expression of your genes) to change your estrogen production. We talk about the genes CYP1A1, CYP1A2 and CYP1B1 along with 2-hydroxy, 16-hydroxy and 4-hydroxy estrogens. How can you get your genetics tested? Head to: bit.ly/3J1IK7I Episode link and resources Personal Instagram, @mrsaprilguilliams: bit.ly/3hj9jt1 Podcast Instagram, @betterhealthpodcast: bit.ly/3JWAqpX YouTube: bit.ly/3hwR7vW

[Dr.Amp Podcast ตอนพิเศษ] เคล็ด(ไม่)ลับ เพื่อสุขภาพดีของหมอแอมป์ EP.1 การกินเพื่อสุขภาพของหมอแอมป์ ฟังเรื่องเล่า 9 เคล็ดลับการกินเพื่อสุขภาพของคุณหมอแอมป์ พร้อมที่มาของหลักการและวิธีคิดในการเลือกทานอาหารของคุณหมอ รวมถึงอาหารมื้อโปรดของคุณหมอว่ามีอะไรบ้างได้ที่ตอนนี้เลย แหล่งอ้างอิง 1. Kleinman RE, Hall S, Green H, Korzec-Ramirez D, Patton K, Pagano ME, Murphy JM. Diet, breakfast, and academic performance in children. Annals of Nutrition and Metabolism. 2002;46(Suppl. 1):24-30. 2. Shinohara M, Saitoh M, Nishizawa D, Ikeda K, Hirose S, Takanashi JI, Takita J, Kikuchi K, Kubota M, Yamanaka G, Shiihara T. ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus. Neurology. 2013 Apr 23;80(17):1571-6. 3. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H. Coffee, CYP1A2 genotype, and risk of myocardial infarction. Jama. 2006 Mar 8;295(10):1135-41. 4. Childs E, Hohoff C, Deckert J, Xu K, Badner J, De Wit H. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology. 2008 Nov;33(12):2791-800. 5. Rétey JV, Adam M, Khatami R, Luhmann UF, Jung HH, Berger W, Landolt HP. A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clinical Pharmacology & Therapeutics. 2007 May;81(5):692-8. 6. Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C→ A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. British journal of clinical pharmacology. 1999 Apr;47(4):445-9. 7. Koskinen L, Romanos J, Kaukinen K, Mustalahti K, Korponay-Szabo I, Barisani D, Bardella MT, Ziberna F, Vatta S, Széles G, Pocsai Z. Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations. Immunogenetics. 2009 Apr;61(4):247-56. 8. Monsuur AJ, de Bakker PI, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A, van Heel DA, Crusius JB, Wijmenga C. Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PloS one. 2008 May 28;3(5):e2270. 9. Pietzak MM, Schofield TC, McGinniss MJ, Nakamura RM. Stratifying risk for celiac disease in a large at-risk United States population by using HLA alleles. Clinical Gastroenterology and Hepatology. 2009 Sep 1;7(9):966-71. 10. Vatta S, Fabris A, Segat L, Not T, Crovella S. Tag–single nucleotide polymorphism–based human leukocyte antigen genotyping in celiac disease patients from northeastern Italy. Human immunology. 2011 Jun 1;72(6):499-502. แหล่งอ้างอิงเพิ่มเติม https://docs.google.com/document/d/1DGoUKC2JBkoIxoW6uLJqulYco_jkQKAPqmLNVS58qxE/edit?usp=sharing

On this episode, I discuss duloxetine pharmacology, adverse effects, and common drug interactions. Duloxetine is an SNRI that is used for depression, anxiety, and various pain syndromes like neuropathy and fibromyalgia. Duloxetine can inhibit CYP2D6 which can lead to higher concentrations of clozapine and propranolol and lower activity of tamoxifen. CYP1A2 inhibitors like ciprofloxacin can raise concentrations of duloxetine leading to an increased potential for adverse effects.

Paul DeJoe is a Co-Founder and COO of MUDWTR, a company that creates a coffee alternative aimed to optimize one's mind, body and ritual. Their product is made with organic ingredients used by cultures young and old for their health and performance benefits. The flagship product is an elixir consisting of masala chai, cacao, turmeric, cinnamon, sea salt and four mushrooms: chaga, reishi, lion's mane and cordyceps. It has 1/7th the caffeine of coffee, and is crafted to give energy, focus and immune benefits without the jitters, crash and dependency.   To find out more about MUDWTR, check out their website.     In this episode we discuss: How a mind-opening concert experience lead to the creation of MUDWTR The importance of ritual, and the equal importance of periodically evaluating our habits The challenge of competing with one of the most widely used addictive substances Creating a company culture that reduces anxiety and leaves space for 10x ideas to grow What it is. Why we want it. And how to encourage it.   Key Takeaways: It was refreshing to hear how MUDWTR built their employee benefits from a blank slate. How they intentionally consider what it is that they're trying to create, and experiment with the best way to create it—with curiosity, checking in on what's working and what's not, and adjusting as needed. I can't help but think what a gift it can be when there isn't a playbook to follow, when there isn't someone to copy from. It's a slippery slope, and a sticky trap, doing things the way you “should” be doing them. When we humbly, and vulnerably share with each other the obstacles in life we've personally wrestled with, it allows others to see us more clearly, and it helps break the unhealthy curated narratives we're constantly surrounded by. It's sharing that allows us to connect deeply and understand we aren't alone. As a leader, it's part of your job to ensure your employees aren't burning themselves out. We have created a culture that wears burnout, lack of sleep and “busy” as badges of honor. It's going to take intention to break that culture and replace it with balance. Your employees, and your company, will be better for it. As a leader it's up to you to lean in with curiosity, test and find creative ways to instill a culture of balance, and (equally important) to model that behavior yourself.   References: Follow MUDWTR on Instagram National Center for Biotechnology Information page for the CYP1A2 gene Trends With Benefits Atomic Habits: An Easy & Proven Way to Build Good Habits & Break Bad Ones by James Clear MUDWTR Co-Founder Shane Heath's interview in Thrive Global Frontiers in Psychology article on neuroplasticity The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity by Norman Doidge Multidisciplinary Association for Psychedelic Studies (MAPS) Eight Sleep Oura Ring Pachama Paul has graciously invited entrepreneurs to reach out for advice. You can email him here.   Connect & Share: If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading them!   If this episode resonated with you, I ask you to send it to a friend. Help bring even more visibility to these leaders that are using business as a force for good!   Subscribe to the Purpose and Profit newsletter to make sure you don't miss future episodes.   This podcast is for you, the listener. I'd love to hear what resonated with you, or if you have a suggestion on who would be a great guest for this show. Please send me a note at info@KathyVarol.com.

A 57-year-old male CEO, with problems with memory. Pt has borderline blood pressure.  Problems with memory started with taking a statin.  Pt also has issues with borderline blood sugar HGA1C is 5.8  and bloating.    Loses weight by avoiding fats and carbs   Patient's top objectives  1. Memory 2. Borderline blood sugar 3. Borderline blood pressure   Cardio Panel: ·       SLCO1B1(rs4149056) ·       ACE (rs4343) ·       AGT (rs699) ·       CYP1A2 (rs762551) ·       LIPC (rs1800588) ·        PPARD(rs2016520 Metabolic Panel ·       MC4R(rs17782313) ·       FTO (rs9939609)   Resources Nutrigenomics Case Study Events 2021  GMOTG Events Line-up PureGenomics Schedule a complimentary 1:1 Welcome to PureGenomics coaching session

The first body system we cover is gastrointestinal and famotidine is one of the H2 blockers we use for conditions like GERD. Find the book here: https://adbl.co/3wAZEmN and TonyPharmD YouTube Channel here: https://www.youtube.com/c/tonypharmd GI: -tidine (not -atadine or -ine) “to dine” Famotidine, (Pepcid), Nizatidine (Axid), Cimetidine (Tagamet) are H-2 receptor antagonists. Ranitidine (Zantac) is off the market. MOA: The stomach's parietal cells secrete stomach acid to lower pH. Histamine-2 will binds the receptors and stimulate them to produce acid. By blocking histamine-2 we can reduce the secreted stomach acid. Indications: Used for GERD and peptic ulcers, conditions of acid secretion disorders such as Zollinger-Ellison syndrome. Pharmacokinetics: The onset of action is a bit faster than PPIs which include omeprazole (Prilosec) and esomeprazole (Nexium), but not near as fast as an antacid which works right away, but the antacid only works for a few hours. Side Effects: Renal (kidney) dose adjustment and can raise serum creatinine as it is a potent inhibitor of tubular creatinine secretion, normally a marker of poor kidney function, though the patient has normal kidney function. Can antagonize testosterone which can lead to sexual dysfunction and gynecomastia (breasts in men). Spironolactone (Aldactone), an aldosterone antagonist, can similarly cause gynecomastia.   B12 deficiency along with proton pump inhibitors, decreased acid leads to malabsorption. Drug Interactions: Since ranitidine (Zantac) was pulled from the market patients might see cimetidine as an OTC alternative, but it does have many drug interactions. Can inhibit the enzymes CYP1A2 (theophylline, asthma), CYP 3A4 (verapamil, CCB), CYP 2C19 (citalopram, SSRI), decrease effects of CYP2D6 (carvedilol, 3rd generation beta blocker) Inhibits enzymes that break the drug down therefore you have more drug which equals toxicity. GMRINCE Neuro/Psych Atypical antipsychotic – aripiprazole (Abilify) Traditional Antiepileptics – carbamazepine (Tegretol), phenytoin (Dilantin) Parkinson's – pramipexole (Mirapex ER) SSRIs – citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac) Cardio Anticoagulant – warfarin (Coumadin) Antihypertensives – carvedilol (Coreg), a beta blocker, verapamil, a non-dihydropyridine calcium channel blocker Antiarrhythmic - amiodarone, risk of QTc prolongation Endocrine Antidiabetics – metformin (Glucophage), a biguanide or glipizide (Glucotrol XL), a sulfonylurea    

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.14.296467v1?rss=1 Authors: Connick, J. P., Reed, J. R., Cawley, G. F., Backes, W. L. Abstract: Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum-bound enzymes that rely on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electrons necessary for substrate metabolism. Although the HO-1 and P450 systems are interconnected due to their common electron donor, they generally have been studied separately. As the expression of both HO-1 and P450s are affected by xenobiotic exposure, changes in HO-1 expression can potentially affect P450 function, and conversely, changes in P450 expression can influence HO-1. The goal of this study was to examine interactions between the P450 and HO-1 systems. Using bioluminescence resonance energy transfer (BRET), HO-1 formed HO-1P450 complexes with CYP1A2, CYP1A1, and CYP2D6, but not all P450s. Studies then focused on the HO-1/CYP1A2 interaction. CYP1A2 formed a physical complex with HO-1 that was stable in the presence of POR. As expected, both HO-1 and CYP1A2 formed BRET-detectable complexes with POR. Whereas the PORCYP1A2 complex was readily disrupted by the addition of HO-1, the PORHO-1 complex was not significantly affected by the addition of CYP1A2. Interestingly, enzyme activities did not follow this pattern. Whereas BRET data suggested substantial inhibition of CYP1A2-mediated 7-ethoxyresorufin deethylation in the presence of HO-1, its activity was actually stimulated at subsaturating POR. In contrast, HO-1-mediated heme metabolism was inhibited at subsaturating POR. These results indicate that HO-1 and CYP1A2 form a stable complex and have mutual effects on the catalytic behavior of both proteins that cannot be explained by simple competition for POR. Copy rights belong to original authors. Visit the link for more info

Tizanidine is primarily broken down by CYP1A2. Ciprofloxacin can inhibit CYP1A2 and cause higher tizanidine concentrations. Tizanidine has a similar classification as clonidine. Pay attention to adverse effects like hypotension and bradycardia. When patients taking routine tizanidine stop taking it, there is potential for a discontinuation syndrome that may lead to rebound hypertension. Dry mouth and CNS depression are common adverse effects of tizanidine.

Valacyclovir can be used for various viral infections such as herpes virus and varicella. The primary clinical advantage of valacyclovir compared to acyclovir is that it is dosed less frequently. Valacyclovir may have some mild CYP1A2 inhibitory effect. I discuss the clinical relevance of this on this episode. GI upset can occur so I usually recommend to give it with food even though it may be given with or without food.

Caffeine is a commonly used supplement and is found in many food and beverages. I discuss caffeine pharmacology, adverse effects, and drug interactions. Caffeine can inhibit CYP1A2 and also be affected by CYP1A2 inhibitors. I discuss some examples in the podcast. It is critical to inquire about caffeine intake when patients are reporting insomnia. Caffeine has been associated with increases in pulse and blood pressure. Be sure to ask about caffeine intake when assessing these vital signs.

Intro- Where do Queens? Where do Queens do what they do? Where do they collaborate? Where their heart is lit up Queens make their space feel homey, no matter where the space is Warm, loving energy in the environment should match the energy inside Where do Queens heal? In intimate community with someone else Where do Queens express themselves? Everywhere. The minute you start stifling your expression, your voice, you’re dimming your light.  Where do Queens learn? In every aspect of our lives Seek out people to teach us who are further along than we are Again, community Where do Queens create? You’re always creating. The moment that you pick up the brush, or the pen, or the camera, then you’re expressing. But you’re always creating Live life like a sustainable farmer: rotate your fields. It saves the soil. Sometimes, a field needs to be burned and left for a while, so the soil can regenerate. So much is happening underneath the soil when it seems to just be dead When it’s ready, new seeds can be planted for harvest Let yourself die. Because the transformation is radical. Every time. Kara Ladd interview How has being a survivor of cancer impacted your life now, a few years out of treatment? COVID-19 diagnosis triggered the same parallels in Kara’s life when she was in cancer treatment Pre-cancer and post-cancer person Life is a repetition of the same themes so that we can learn each intricate layer What has your physical journey translated to in terms of your relationships? The relationship with myself changed the most I thought I knew myself pre-cancer and pre-trauma, but I realized that I was confined to a mold I created as a 13 year old. And the trauma forced me to embrace self-love and self-care on a whole new level. That then impacted every other relationship I had Shaped her health and spirituality and way of being You don’t have to go through trauma to have a profound shift in consciousness Find the miracle of just being in this human body The minutiae of life IS life How has living in STL and NY shaped your understanding of Queendom? Grounded and independent What does conscious dating look like as a nomad? Dating apps became a numbing tool. Once that was clear, she got off of them Strong sense of embodied love has catapulted her view of love Manifestation lists bring clarity about what and who you want Spiritual, conscious focus is at the top of the list What was the trigger that catapulted your career so quickly? Used to be so focused on forcing things to happen, now I allow them to flow Really getting comfortable in the empty space allowed others to be attracted in who could help me move forward  Taking a step back from “optimizing” and just listen to what my body feels and needs Alisa Vitti, “In the Flow” How to cycle your life with your body Magic and power come from rest Business cycle with the moon and with your hormonal cycle POWR  Plan (follicular phase) Open Up (Ovulation) Work (Luteal) Rest (Menstrual) What seeds do you want to plant with our audience to “Grow the Queendom?” Listen “Hector and The Search for Happiness”- listening is loving. It is an act of love.   Q&A : Why should I avoid coffee? https://www.floliving.com/3-reasons-why-women-cant-drink-coffee/ Caffeine causes cyst formation in the breast and ovaries Cafffeine is broken down by the enzyme CYP1A2 90% of the population only make a little bit of this enzyme, and can’t break down caffeine well. Caffeine increases infertility rates 3 cups of coffee a day consumed by women or men increases the risk of miscarraige by 74% Caffeine depletes the body of micronutrients that are essential for hormone balance What do I use to replace coffee? Dandelion root, my favorite brand is “Dandy Blend.” Send in your questions: queen@growthequeendom.com; IG and FB- @queendom.come.podcast Online video coaching with me through BEAM+Flow “Embodied Flow Sessions” (bodywork, feelings, hormone balancing, creative coaching)- beaming@beamandflow.com IG and FB: @beam.and.flow or @chloecofresi Moment of Flow “Burning Lights” by Chloé Cofresí   I have sailed across time to find you I live in you The flower that grows The seed never knew  Time warps the story Changes the players Cuts and punches Collapsed in the corner  On the bed In my life Breath comes in And I’m more than a player   The view is worth the time Breathe now She shadows me in Wisdom And I am lit   I walk with Time Make myself the honey trap  No one is gonna tell What’s mine to show I stand on a cracking city block But I feel Mi Tierra under my feet The salt from food trucks Is El Mar in my nose That’s not a train racing by It’s El Viento ripping through trees   The view is worth the time Breathe now She shadows me in Wisdom And I am lit   I cross this ocean  Flooded by their stories I’ve sailed across time Chased it, cursed it, mastered it Know Her Secret? Time is always and now Keep breathing, see all of now Stop breathing, see always   The view is worth the time Breathe now She shadows me in Wisdom And I am lit

Časovnica: [00:00:55] O projektu nadaljnjega izobraževanja o prehrani, vadbi in kritični presoji literature. Kultura pogovora preko socialnih omrežij ter epilog poizkusa svetovnega rekorda v mrtvem dvigu. [00:19:35] Inteligenca in kritično razmišljanje nista ista stvar. Zakaj pametni ljudje počnejo neumnosti. Zakaj je kritično razmišljanje ključ do dobrega življenja. [00:31:25] Kofein kot dopolnilo za izboljšanje zmogljivosti ter kako genotip vpliva na časovni vnos kofeina. [00:44:25] Vpliv mikrobiote in probiotikov na hujšanje. Visok vnos vlaknin in nižji vnos maščob za optimalno zdravje prebavil. [01:15:05] Zakaj vzdržljivostni športniki potrebujejo več beljakovin. [01:22:45] Zaključek.   Omenjeni članki: Zakaj pametni ljudje počnejo neumnosti: Why Do Smart People Do Foolish Things: https://www.scientificamerican.com/article/why-do-smart-people-do-foolish-things/ Vpliv genotipa na jemanje kofeina: Grgic et al. CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance. J Int Soc Sports Nutr 17, 21 (2020). https://doi.org/10.1186/s12970-020-00349-6 Mikrobiota in hujšanje: Fragiadakis. et al. (2020) ‘Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight', The American Journal of Clinical Nutrition. Oxford University Press, pp. 1–10. https://doi.org/710.1093/ajcn/nqaa046  Hjorth et al. (2018) ‘Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention', International Journal of Obesity. Nature Publishing Group, 42(3), pp. 580–583. https://doi.org/10.1038/ijo.2017.220 Višji vnos vlaknin in nižji vnos maščob za optimalno zdravje prebavil: O'Keefe et al. (2015) ‘Fat, fibre and cancer risk in African Americans and rural Africans.', Nature communications, 6(May 2014), p. 6342. https://doi.org/10.1038/ncomms7342 Le Leu et al. (2015) ‘Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: A randomised clinical trial', British Journal of Nutrition, 114(2), pp. 220–230. https://doi.org/10.1017/S0007114515001750 Meta-analize o učinkovitosti probioikov pri hujšanju: Mazloom et al. (2019) ‘Probiotics: How Effective Are They in the Fight against Obesity?', Nutrients, 11(2), p. 258. https://doi.org/10.3390/nu11020258 Mohammadi et al. (2019) ‘Effects of pro-/synbiotic supplementation on anthropometric and metabolic indices in overweight or obese children and adolescents: A systematic review and meta-analysis', Complementary Therapies in Medicine. Elsevier Ltd, 44, pp. 269–276. https://doi.org/10.1016/j.ctim.2019.05.008 Cao. et al. (2020) ‘Effect of probiotic and synbiotic formulations on anthropometrics and adiponectin in overweight and obese participants: A systematic review and meta-analysis of randomized controlled trials', Journal of King Saud University - Science. The Author(s). https://doi.org/10.1016/j.jksus.2020.01.011 Potrebe vzdržljivostnih športnikov po beljakovinah: Kato et al. (2016). Protein Requirements Are Elevated in Endurance Athletes after Exercise as Determined by the Indicator Amino Acid Oxidation Method. PloS one, 11(6), e0157406. https://doi.org/10.1371/journal.pone.0157406 Bandegan et al. (2019). Indicator Amino Acid Oxidation Protein Requirement Estimate in Endurance-Trained Men 24h Post-Exercise Exceeds both the EAR and Current Athlete Guidelines. American Journal of Physiology-Endocrinology and Metabolism, 316(5):E741-E748. https://doi.org/10.1152/ajpendo.00174.2018   Sledite nam: Nenadov instagram: @nenad.feelgood Matjažev instagram: @matjaz.feelgood Feelgood Skupnost na Facebooku: https://bit.ly/feelgoodskupnost Spletna stran: https://www.feel-good.si   Poslušate nas lahko na: Podbean: https://bit.ly/podbean-zdp Stitcher: https://bit.ly/stitcher-zdp Pocket Casts: https://bit.ly/pocket-zdp Podcast Addict: https://bit.ly/addict-zdp Castbox: https://bit.ly/castbox-zdp iTunes: https://bit.ly/itunes-zdp  

Wishing you could get a better night's sleep without waking up all itchy? When sleep is compromised (or nonexistent) night after night, it can feel like you'll never catch up. The cumulative effect of sleepless nights is maddening. Clients in my clinical practice often ask me “How can I sleep better?” The truth is, there's not one simple answer to that question. Ultimately you have to figure out what's causing the issue in the first place. But some supplemental aides like melatonin might be helpful for some. I've repeatedly seen studies mention lower nightly melatonin levels in those with eczema. And how the use of the supplement could be helpful! Let's dive in together to see if melatonin could be helpful for you. In this episode: What is melatonin and can it be helpful for someone struggling with itchy eczema? Melatonin production tends to be low in eczema patients Food sources of melatonin (more than just tart cherries) How to naturally boost melatonin production Thoughts on supplementing with melatonin to avoid waking up groggy Who shouldn't take melatonin Quotes: “33 to 87.1% of adults” and “83% of children with eczema” are dealing with some sort of sleep disturbance or difficulty staying asleep. Melatonin is broken down by your liver specifically in Phase 1 of liver detoxification by the CYP1A2 enzyme (along with some others) to get it out of your system.

#65: 9 Ways to Have More Energy, with Host Marisa MoonShort Summary:Are you ready to hear my top 9 ways to have more energy every day? I am throwing in a few bonus ways too. I made an infographic for this topic on my instagram @marisa_moon_ and the response was really awesome! I knew it was time to shape that into a podcast, and here we are... Join me inside my new facebook group: “The Foundation of Wellness - a Refreshing Diet & Lifestyle Chat”facebook.com/groups/FOWpodcastInfographic for this post: instagram.com/marisa_moon_For professional Inquiries contact - Marisa Moon, Certified Primal Health Coach: marisa@marisamoon.com;Disclaimer: Consult with your doctor or functional medicine practitioner before trying any of the remedies or dietary interventions mentioned in this episode. This information and recording is for informational and educational purposes only.#1 Eat adequate protein#2 Adopt a strict sleep routine#3 Eat your last meal at least 3 hours before bed#4 Practice daily intermittent fasts#5 Avoid Alcohol at least 2 Hours Before Bed#6 Avoid Caffeine after 1pm (or around 10-12 hours before bed)#7 Remove Foods that are Causing an Intolerance in your Body#8 Eat a Lunch made of Slow-Cooked Foods#9 Get Support for your Chronic Stress and or AnxietyBonus: Vitamin B-complet & B-12 (natural, not synthetic forms)Bonus: Molecular HydrogenBonus: Ketone Esters Resources:- Chris Kresser 5 Reasons You May Need More Protein: https://chriskresser.com/5-reasons-you-may-need-more-protein-even-on-a-paleo-diet/ - Desiccated Liver Capsules - https://www.vitalproteins.com/products/beef-liver-capsules - Spirulina tablets “Energy Bits” (20% off discount code: “FOWPodcast”): https://www.energybits.com/ - Algae/Spirulina Podcast Episode #51: https://www.spreaker.com/episode/18575992 - Sleep Podcast Episode #18 (2 of 2): https://www.spreaker.com/episode/15658158 - HCL with Pepsin Supplement (for low stomach acid) - https://store.chriskresser.com/products/betaine-hcl-pepsin - Intermittent Fasting Guide: marisamoon.com/iffreedom - Caffeine & Coffee Podcast Episode #26: https://www.spreaker.com/episode/16085892 - Caffeine Metabolism Genetic Testing: “CYP1A2” Gene- Elimination Diet Podcast Episodes #10 & #11: https://www.spreaker.com/episode/15595022 - Autoimmune Protocol “AIP” Diet: #54: https://www.spreaker.com/episode/18745536 - Dairy Intolerances Podcast Episode #30: https://www.spreaker.com/episode/16386645 - Hydrogen Tablets (rejuvenation H2 magnesium tablets) Drinkhrw.com (or Chicago company Hi-Vibe sells them)- Learn about Molecular Hydrogen in Podcast Episode #46: https://www.spreaker.com/episode/18264205 - Ketone Esters: https://ketoneaid.com - Explore Health Coaching with Marisa: marisamoon.com/consultation Marisa's site: https://www.marisamoon.com Facebook Group: facebook.com/groups/FOWpodcast Podcast Facebook Page: https://www.facebook.com/FoundationofWellnessPodcast Instagram: @foundationofwellness_podcast https://www.instagram.com/foundationofwellness_podcast @marisa_moon_ https://www.instagram.com/marisa_moon_ Intro/Exit Music  - "Ukulele Whistle" by Scott Holmes

On this episode "Acyclovir Pharmacology" I discuss the mechanism of action, important monitoring parameters, and drug interactions with acyclovir. I discuss why acyclovir has to be dosed so many times per day. Acyclovir can inhibit CYP1A2 which can impact a few drugs. I discuss a couple of those examples on this podcast episode. GI effects are one of the more common side effects of acyclovir. Rarely, neuropathy and nephropathy can be part of the adverse effect profile of acyclovir. I discuss this further on this episode.

Show Notes By Jacqueline Posada, MD, 4th-year resident in the department of psychiatry & behavioral sciences at George Washington University, Washington. In this episode, Lorenzo Norris, MD, host of the MDedge Psychcast, interviews Jonathan M. Meyer, MD, about prescribing clozapine and understanding barriers of use. Dr. Meyer is clinical professor of psychiatry, University of California, San Diego, and a psychopharmacology consultant with the California Department of State Hospitals. Overview of clozapine Clozapine is an effective medication for treatment-resistant schizophrenia and lethality/suicide. Clozapine is underused by clinicians for many reasons. Clinicians have less comfort with prescribing clozapine. Too few trainees are exposed during residency to prescribing clozapine. Using clozapine during training provides the knowledge and comfort necessary to prescribe it once out in practice. Fear of prescribing clozapine outweighs the benefits to patients who need it. Other barriers include monitoring burdens in confluence with systems issues. Indications for use Treatment-resistant schizophrenia is defined as an inadequate response to two antipsychotic trials, and treatment-resistant schizophrenia occurs in about 30% of patients with schizophrenia. People with treatment-resistant schizophrenia have a 5% chance of responding to other antipsychotic medications, while the response rate to clozapine is about 40%. In light of those statistics, getting patients with schizophrenia on clozapine should be a priority. Everyone benefits when a patient with treatment-resistant schizophrenia is started on clozapine. Clozapine treatment leads to decreased symptoms and suffering, improved quality of life, decreased suicidality and aggression, and lower hospitalization rates, which in turn, lead to decreased health care costs. Barriers to using clozapine Education is key to empowering physicians to start prescribing clozapine and overcoming the initial resistance to prescribing. SMI Adviser is a website sponsored by the American Psychiatric Association (APA) and the Substance Abuse and Mental Health Services Administration (SAMHSA) that provides access to education, data, and consultations for clinicians who treat serious mental illness. SAMHSA also has sponsored “centers of excellence” in New York state and the Netherlands that provide consultation and on-demand answers to questions about prescribing. The Clozapine Handbook, written by Dr. Meyer and Stephen M. Stahl, MD, PhD, is another centralized resource for prescribers. Dr. Meyer and Dr. Stahl wrote the handbook to educate and encourage clinicians to prescribe clozapine and improve patient outcomes.  Adverse events and monitoring Myocarditis: Rate of myocarditis ranges from 0.5% to 3% (most rates from Australia), an adverse event that happens primarily within the first 6 weeks of clozapine therapy. Symptoms suggesting myocarditis include fever and elevated troponin level more than twice the upper limit of normal. Clinicians can order a C-reactive protein test, which can help rule in myocarditis if troponins are elevated but not at twice the upper limit range. In the first 6 weeks of therapy, clinicians are encouraged to order a troponin test during the patients' weekly labs. Isolated fever does not mean myocarditis, because fever is a common side effect during titration, and clinicians can complete the fever work-up. Cigarette smoke can induce cytochrome P450 (CYP) enzyme, including CYP1A2. It is not necessary to have patients stop smoking when they start clozapine. Clinicians can adjust the clozapine dose based on response and clozapine level. Induction of CYP1A2 enzyme happens only when people smoke or burn the actual leaf of tobacco or marijuana. Vaping or e-cigarettes will not induce CYP1A2 and change clozapine levels. Threshold of response is 350 ng/mL, however levels that lead to response differ with each individual and will be influenced by smoking habits. Other common side effects include orthostasis, sedation, and sialorrhea. New technologies are available to reduce barriers of prescribing clozapine and to improve patient adherence to hematologic monitoring. Athelas is a company that manufactures a Food and Drug Administration–cleared point-of-care device to measure neutrophil count by way of a finger stick. Results are dispensed real time. Athelas also will take care of medication dispensing. A point-of-care device is in development for plasma clozapine levels with fingerstick, which will allow clinicians to make titration decisions in real time instead of 1 week after levels. The device already is available in Europe. Creating a system that allows for adherence Using case managers to improve clozapine adherence is cost effective when the amount saved from avoiding hospitalization is taken into account. Clozapine can lead to a functional recovery in terms of how a patient interacts with family, friends, and society at large. Clozapine has the ability to improve productivity leading to employment, which is another way the benefits of creating a system to improve clozapine adherence outweigh financial costs.   References Kane JM et al. Clinical guidance on the identification and management of treatment-resistant schizophrenia. J Clin Psychiatry. 2019 Mar 5;80(2): doi: 10.4088/JCP.18com12123. Suskind D et al. Clozapine response rates among people with treatment-resistant schizophrenia: Data from a systematic review and meta-analysis. Can J Psychiatry. 2017 Nov;62(11):772-7. doi: 10.1177/0706743717718167. Kelly DL et al. Addressing barriers to clozapine underutilization: A national effort. Psychiatr Serv. 2018 Feb 1;69(2):224-7. Bui HN et al. Evaluation of the performance of a point-of-care method for total and differential white blood cell count in clozapine users. Int J Lab Hematol. 2016 Dec;38(6):703-9.   Other resources SMI Adviser: Clozapine Center of Excellence, sponsored by the APA and SAMHSA. The Clozapine Handbook (Cambridge University Press, 2019). Clozapine and smoking cessation (NSW Health, Australia). Point of care neutrophil measurement. https://athelas.com/fda/. https://curesz.org/.   For more MDedge Podcasts, go to mdedge.com/podcasts   Email the show: podcasts@mdedge.com   Interact with us on Twitter: @MDedgePsych              

is a new book, by my fellow C-ISSN and CSCS Dr. Marc Bubbs. It was one of my best reads of the year for all things sports science. A few of my big takeaways include: – Endurance athletes seem to need more sleep than strength athletes, and both seriously suffer when sleep is anything less than 6 hours. – A temperature change in your fingertips is likely the first circadian cue you get at the beginning of the day (I could totally see a potential jet lag device that warms the fingers – I’ll take the royalty for that, please. ;) ). – Aerobic training for strength athletes could assist with their immune system strength. – Loading with probiotics for 2 weeks leading up to competition could give you an ergogenic edge. – Elite athletes on a subpar diet show the same blood biomarkers as those with pre-diabetes and a fructosamine blood test can be one of the best ways to measure this. – Top supplements proven to work in exercise science, with the strongest track history, are creatine, caffeine, nitrate precursors (e.g. beet), whey protein, beta-alanine, and sodium bicarbonate. – Athletes with the CC genotype of the CYP1A2 gene are actually hampered in performance in response to caffeine intake. – Eating carbs too far from a performance event (e.g. 60-75 minutes) results in hypoglycemia before the event vs. consuming them closer to the event (e.g. 20-45 minutes) – Fish oil can stimulate muscle building by stimulating mTOR pathways. Vitamin D and creatine are also very good for recovery, not just performance. Creatine can even be helpful for TBI/concussions. – High sugar intake is associated with lower heart rate variability (HRV). – Cold water immersion (CWI) beats cryotherapy for recovery, hands down. You can . But I also decided to get author Dr. Marc Bubbs on this podcast to take a deeper dive into he concepts above, and many others. He is a licensed Naturopathic Doctor, Performance Nutrition Lead for Canada Basketball Team, Speaker, and former Strength Coach. Marc also hosts the Dr. Bubbs Performance Podcast, connecting listeners with world-leading experts in human performance and health. Dr. Bubbs regularly presents at health, fitness and medical conferences across North America, UK and Europe and consults with professional teams in the NBA, NHL, and MLB teams. He practices in both Toronto, Canada and London, England. During our discussion, you'll discover: -How Marc gathers, curates and assimilates new information for his practice...8:45 Struggled as a young athlete with disease, etc. and discovered naturopathic medicine He realized that there wasn't much of a market for it (circa 2000) but he embraced it and became the best at it The more personal contact with the source of info, the better (there's nuance in conversation that doesn't make it into an academic paper) Vast resources available on the Internet (and they're all true, of course) -Current research on caffeine as an ergogenic aid...15:00 Study conducted by : Cycling time trial under 3 different conditions: 0 caffeine 2 mg caffeine 4 mg per kg of caffeine AC gene variants had no benefit AA gene variants had benefit at both 2 mg and 4 mg levels Athletes with the CC genotype of the CYP1A2 gene are actually hampered in performance in response to caffeine intake The sweet spot: 3-6 mg of caffeine per kg per day 23 and Me test will identify CYP 1A2 gene -How endurance and strength athletes differ regarding sleep needs...21:18 Endurance athletes fare better on the upper end of the sleep suggested amounts (8-10 hrs) They also suffer more on lack of sleep Greater volume of training More early morning sessions Sleep is #1 recovery tool some docs recommend It's one thing to acknowledge the need, quite another to actually get more sleep -The relationship between finger temperature and circadian rhythm...31:25 Fingertips are the first to sense changes in environment Possibility of warming hands to help body adjust its circadian rhythm while traveling -How aerobic training can help the immune system of endurance athletes... "Elite performance is incompatible with frequent illness." --Dr. Michael Gleason Maintaining an aerobic base supports innate immunity Aerobic training in the protocol of a strength athlete will improve immune system Consider incorporating aerobics if red flags of sickness or fatigue occur Could be a means of recovery Simply being well enough to train is a big part of the picture Don't forget fundamentals like washing hands Fingertips, webs and backs of hands are often missed -Probiotics as an ergogenic and performance enhancing tool...42:10 Study on Olympic athletes in 2008: 2/3 of those studied showed benefit in 2 key areas: Preventing upper respiratory tract infection Reversing upper respiratory tract infection Start 2 weeks before event Colostrum can be efficacious while performing in the heat Gut is a "black box" of the body; a key indicator in assessing overall health -Up and coming supplement research and diet strategies Marc is following...50:45 "Food first" approach Creatine, whey protein, caffeine are major players Nitrate precursors: beet root, arugula Endurance sports, struggle to lose weight: have the wrong approach Nicotinamide riboside Ketones for concussion recovery High rate of head trauma among teens Women's ice hockey is the highest risk Peptides -Why athletes on a subpar diet show the same blood biomarkers as those with pre-diabetes...56:10 Endurance athletes are more concerned with hypoglycemia, not hyperglycemia Study: 4 of 10 participants spend 70% of the time with blood glucose in pre-diabetic range Exercise is a stressor; contributes to raising blood glucose Over fueling more of a problem than we think Case study in Japan on two ultra-marathoners: one elite, the other sub-elite on a 100 mile race At wake-up: elite has glucose level of 90; sub-elite is 110 Sub-elite glucose level rises, then crashes around mile 70 Elite runner came through just fine Fructosamine measurements for blood glucose levels HA1c skews to more recent fueling in its readings 2-3 week window vs. 3 month on HA1c Measuring glycated albumin rather than glycated hemoglobin More expensive; used for a more acute picture -The best time to consume carbs before training...1:07:45 Dr. Mark Russell: Biggest drops in glucose came from those who had drinks 75 minutes before the game  did a study on maltodextrin vs. honey Maltodextrin had blood sugar drop of 19% Honey had blood sugar drop of 4% Time carb intake so that blood glucose spike takes place during the event Optimal overall carb intake for strength vs. endurance athletes: Strength: 4-7 g per kg per day Endurance: 6-10 g per kg "Training low" in team sports: low carb availability -Comparing the effectiveness of cold water immersion (CWI) to cryotherapy...1:22:40 -And much more... Resources from this episode: - - - - -Dr. Mark Russell: Episode sponsors: -: Building blocks for muscle recovery, reduced cravings, better cognition, immunity, and more. Get 10% off your order of Kion Aminos, and everything at the Kion site when you use discount code: "BGF10". -: After using the Joovv for close to 2 years, it's the only light therapy device I'd ever recommend. Give it a try: you won't be disappointed. Order using and receive a nice bonus gift with your order! -: Organic brands you love, for less. Your favorite organic food and products. Fast and free shipping to your doorstep. Receive 25% off your order when you use ! -: Quality is our Gimmick isn’t just our slogan, it’s a commitment we honor with every stitch we sew. 100% money back guarantee. Get 10% off your order, PLUS free shipping on any order over $99 when you use discount code: BENG. Do you have questions, thoughts or feedback for Dr. Bubbs or me? Leave your comments below and one of us will reply!  

On this episode, I discuss clozapine pharmacology. This drug has multiple mechanisms of action: Dopamine blockade, anticholinergic activity, and alpha blocking activity all contribute to the complexity of this drug. Smoking cessation can significantly increase the concentrations of clozapine. This is because smoking can induce CYP1A2. Listen to the podcast for more details on how this can impact our patients clinically. Clozapine has 5 boxed warnings. I discuss them all in this podcast. The most well-known boxed warning is for agranulocytosis. Because clozapine has alpha blocking activity, it can cause orthostasis. We need to monitor for this. Clozapine can cause QTc prolongation. Keep an eye out for other medications that the patient may be taking that can also cause this. Examples include: amiodarone, ondansetron, quinolones, and macrolides

In Episode 144 of Keto Talk, Jimmy and Dr. Will Cole dig into the subject of Functional Medicine and Dr. Cole explains to us exactly what tests every keto dieter should be running and what they mean to you. “It's rarely one thing that is the magic bullet. Normally it's a confluence of different factors. These labs allow us to find the pieces of the puzzle.” – Dr. Will Cole “You can take a shotgun approach with labs and do everything, or use them to really fine tune your health.” – Jimmy Moore The specific tests we talk about in this episode and the ranges you should be looking for: C-reactive protein Inflammation is one primary way disease genes get turned on, and it is generally destructive all over the body. C-reactive protein is an inflammatory protein that, while it is essential for cleaning up bad bacteria, in excess it can lead to accelerated aging, chronic disease, and damage to the telomeres. Optimal Range: < 0.5 mg/L Small dense LDL particles What you thought was “bad cholesterol” (LDL) isn’t all bad, and labelling it so is a simplistic and inaccurate view of cholesterol. LDL particles are proteins that carry cholesterol around in your body. Some of these particles are big and buoyant, while others are small and dense. It’s the small dense LDL particles that can cause damage, while the larger fluffier particles are essentially benign. Knowing your level of small dense LDL particles is much more instructive that simply knowing your total cholesterol, because it is the small dense LDLs – not the cholesterol itself – that indicate a riskfor heart attack and stroke (and thereby put you at risk for an earlier death). Optimal Range: < 200 nmol/L Homocysteine This protein in excess (especially when coupled with a B vitamin deficiency) has been linked to cognitive decline, which can drastically reduce quality as well as length of life. Optimal Range: < 7 Umol/L Hgb A1C This test tells you what your blood sugar has been, on average, for the past two to three months. When it is high, it can indicate pre-diabetes or diabetes, and an elevated A1C has been linked with higher rates of all-cause mortality in patients with diabetes. Optimal Range: < 5.3% Vitamin D This nutrient is responsible for hundreds of different genetic pathways in the body but because most people spend most of their day indoors and get little sun exposure, vitamin D deficiency is rampant. That’s too bad because this deficiency is linked to chronic disease, and optimal levels are linked to an actual preservation of telomeres, meaning you live longer and stay healthier! If that’s not a reason to get a little sunshine, I don’t know what is. Note that vitamin D should be paired with other fat soluble vitamins, like vitamin A and K2, for maximum absorption. Optimal Range: 50-60 ng/mL Fasting insulin When your body breaks down carbohydrates, and to a lesser extent, proteins into glucose, your blood sugar goes up. In response, your pancreas secretes insulin to send your blood sugar into your cells (for energy) and bring down the level in your blood. However, if insulin gets activated too often at too high levels, this has been linked to accelerated aging and telomere shortening. Optimal Range: < 3 ulU/mL C-peptide: Optimal Range: 0.8 to 3.1 ng/mL Fasting blood sugar: Optimal Range: 75 to 90 mg/dL Triglycerides: Optimal Range: < 100 mg/dL HDL: Optimal Range: 59 to 100 mg/dL Hormone testing: Urine and Saliva Other Nutrients: Selenium, Mg, Iron, MMA, Microbiome labs: We look to assess gut health, where around 80 percent of our immune system resides. Intestinal permeability lab: This blood test looks for antibodies against the proteins that govern your gut lining (occludin and zonulin), as well as bacterial toxins that can cause inflammation throughout the body, called lipopolysaccharides (LPS). Multiple autoimmune reactivity labs: This array shows us if your immune system is creating antibodies against many different parts of the body, such as the brain, thyroid, gut, and adrenal glands. The labs are not meant to diagnose an autoimmune disease, but to look for possible evidence of abnormal autoimmune-inflammation activity. Cross reactivity labs: Helpful for people who are gluten-sensitive and who have gone gluten-free and eat a clean diet, but still experience symptoms like digestive problems, fatigue, and neurological symptoms. In these cases, relatively healthy food proteins—such as gluten-free grains, eggs, dairy, chocolate, coffee, soy, and potatoes—may be mistaken by the immune system as gluten, triggering inflammation. To their immune system, it’s as if they have never gone gluten-free. 1. AHCY: This enzyme is responsible for breaking down the amino methionine by converting S-adenosylhomocysteinase into pro-inflammatory homocysteine. Mood disorders are common for those with a double mutation but typically do well with SAMe supplementation. 2. BHMT: The BHMT gene directs the enzyme responsible for the amino acid methionine, the building block in the choline oxidation process for optimal brain function. Changes in this gene are associated with ADHD. 3. CBS No, not the television network! It actually stands for the enzyme that makes the amino acid cystathionine. A mutation of this gene will lead a person to produce more sulfur end products and as a result will need to limit sulfur-rich foods such as legumes and dairy. These foods can increase ammonia levels and contribute to existing health problems. NOS and SUOX are two other genes that can increase sulfur and are linked to immune disorders like asthma. 4. COMT: This gene is responsible for creating a healthy balance of neurotransmitters and, in turn, a healthy brain. A double COMT gene change is associated with increased risk for anxiety, OCD, bipolar disorder, and ADHD. 5. MAO: The main role of the MAO gene is to clear out excess neurotransmitters like serotonin. When changes to this gene occur it can create an imbalance in neurotransmitters leading to increased rates of anxiety and depression. Those with an MAO mutation, as well as the MTHFR gene mutation, can have a higher rate of histamine intolerance. Because of this even healthy foods such as fermented foods, bone broth, and vinegar can increase inflammation. 6. MTHFR: This is not an acronym for a swear word guys, get your mind out of the gutter. The biggest thing I use DNA testing for is to assess methylation, a biochemical superhighway that help your gut, brain, hormones, and detox pathways function properly. This process happens a billion times every single second so if methylation isn’t functioning well, neither are you. Since I often deal with a variety of gut, brain, and hormonal problems in my clinic it is important to see if my patients methylation is working well. The MTHFR enzyme is responsible for converting folic acid into folate which acts as fuel to the methylation process. A1298C and C677T are the two main MTHFR mutation. When A1298C is altered it can lead to mood disorders due to its important role in neurotransmitter function. C677T changes can cause higher levels of inflammatory homocysteine. Both of these are linked to autism and autoimmune conditions like autoimmune thyroid issues. 7. MTR/MTRR: These are necessary for B12 production, another methyl donor. Those who have this mutation need higher intake of B12 because their body uses it faster than it produces it. Oftentimes people who have this genetic change can also be low in lithium which is needed for mood regulation. We can easily check lithium levels through testing blood and hair. 8. VDR VDR stands for vitamin D receptor. Every single cell in your body uses vitamin D. Other than your thyroid hormone, no other nutrient or hormone can claim that importance. It is responsible for over 200 different pathways in the body. Mutations in this gene make it really difficult to absorb vitamin D. It’s important to know if this is the case for you in order to supplement higher doses on a consistent basis to make sure you are getting enough of this vital nutrient. 9. Detox genes I also look for changes in your detox genes such as CYP1A2, also known as your caffeine gene. This can show just how well you can tolerate caffeine and whether or not it can be harmful or beneficial to your health.

Short Summary This episode is all about caffeine. Here we chat the good like improved circulation + better attention. We also chat about the confusing topics like memory, and the bad like interference with sleep + worsened anxiety. Think you're sensitive to this wonder drug? You'll learn how to genetically test to see if you're a fast or slow caffeine metabolizer. Finally, we share some caffeine rules like doctoring it up with healthy fats for steady energy as well as coffee alternatives like mushroom coffee and matcha green tea.For professional Inquiries contact - Jessica jessdogert@gmail.com or Marisa marisa@marisamoon.com Disclaimer: Consult with your doctor or functional medicine practitioner before trying any of the remedies or protocols mentioned in this episode. Jessica Dogert and Marisa Moon are not physicians or medical practitioners.Points of Discussion: Caffeine popularity- HALF of all Americans start their day with coffeeCaffeine benefits- reduced risks of melanoma, type 2 diabetes, heart disease, liver disease, Parkinson's disease, prostate cancer, Alzheimer's, stroke, depression, breast cancer, and memory lossThe cons of caffeineExcessive consumption can:- Worsen stress/anxiety- Interfere with sleep- Slow neurogenesis- Lead to adrenal fatigue syndrome (AFS)- Cause Stomach and GI upset- Contribute to Brain Fog- Lead to burn out- Worsen Long Term MemoryWhy does caffeine make us feel awake?- Adenosine 101Caffeine metabolism- Fast vs slow- CYP1A2 genetic testing (SmartDNA or 23andMe)Popular caffeine sources - Energy drinks, chocolate, weight loss supplements, etcCoffee's affect on our stomach and GI tractCoffee Half-LifeThree caffeine rules1. Drink 2 cups of water before caffeine in the AM2. Doctor up coffee or tea with healthy fats like grass-fed butter, ghee or coconut cream3. Nix caffeine at LEAST 6 hours before bedCoffee alternatives- Mushroom coffee and Matcha green teaWhy quality matters; commercial coffee industry's production practices- Always buy Organic and Arabica coffee beans. Try Bulletproof Brand Coffee Beans and Koin CoffeeDo you love caffeine? Do you tolerate it well? Or does it make you feel anxious and jittery? We want to know so shoot us an email because we'd love to hear from you!Intro/Exit Music - Ukulele Whistle by Scott Holmes

Last month the NBT team had a rare live meet-up at the Ancestral Health Symposium in Bozeman, Montana. While there, we had a chance to see many of our previous podcasts guests in person presenting their latest work. For this podcast, we passed the microphone around and shared our impressions of some of the talks we’d seen. Along the way, we covered all kind of topics, ranging from the performance benefits of caffeine to setting up an ice bath at home. Dr. Tommy Wood shared highlights from his AHS presentation, “The Athlete’s Gut,” explaining why 70% of endurance athletes have a gut problem. We also caught up with friends from Virta Health, who are on a mission to reverse Type 2 Diabetes in 100 Million People.   Here’s the outline of this conversation with Tommy, Megan, Clay, Zach, Josh, and Doug: [00:00:08] Ancestral Health Symposium 2018. [00:00:24] Swiss Water Decaf. [00:01:34] Association of coffee drinking with all-cause mortality; Studies: Loftfield, Erikka, et al. "Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank." JAMA internal medicine 178.8 (2018): 1086-1097. [00:02:55] Caffeine for improved performance; Studies: Astorino, Todd A., and Daniel W. Roberson. "Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: a systematic review." The Journal of Strength & Conditioning Research 24.1 (2010): 257-265; and Ganio, Matthew S., et al. "Effect of caffeine on sport-specific endurance performance: a systematic review." The Journal of Strength & Conditioning Research 23.1 (2009): 315-324. [00:03:09] Effect of CYP1A2 gene + caffeine; Studies: Guest, Nanci, et al. "Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes." Medicine and science in sports and exercise 50.8 (2018): 1570-1578; and Rahimi, Rahman. "The effect of CYP1A2 genotype on the ergogenic properties of caffeine during resistance exercise: a randomized, double-blind, placebo-controlled, crossover study." Irish Journal of Medical Science (1971-) (2018): 1-9. [00:03:39] Caffeine gene: CYP1A2; marker (SNP): rs762551; Click here to check your 23andMe results. AA: faster metabolizer of caffeine; AC: medium metabolizer; CC: slower metabolizer. [00:03:56] Podcast: How to Drop Your Cholesterol, with Dave Feldman. [00:04:23] Lean Mass Hyper-responders. [00:05:35] Podcast: Why Cholesterol Levels Have No Effect on Cardiovascular Disease (And Things to Think about Instead), with Dr. Malcolm Kendrick. [00:08:06] Inversion pattern. [00:10:56] Podcast: How Not to Die of Cardiovascular Disease, with Ivor Cummins. [00:11:14] Book:  Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health, by Ivor Cummins. [00:11:19] Podcast: The True Root Causes of Cardiovascular Disease, with Dr. Jeffry Gerber. [00:11:42] Peter Attia. [00:12:05] Dr. Tim Gerstmar Podcasts: How to Test and Predict Blood, Urine and Stool for Health, Longevity and Performance and Methylation and Environmental Pollutants. [00:12:15] AHS 2014 Talk: Methylation: How 1 Carbon Affects Your Brain, Your DNA and Everything - Tim Gerstmar, N.D. [00:13:06] Book: Antifragile; Nassim Taleb’s Lindy Effect. [00:14:22] Autoimmune Protocol (AIP) diet [00:17:48] Podcast: Optimal Diet and Movement for Healthspan, Amplified Intelligence and More, with Dr. Ken Ford. [00:17:55] Study: Fain, Elizabeth, and Cara Weatherford. "Comparative study of millennials' (age 20-34 years) grip and lateral pinch with the norms." Journal of Hand Therapy 29.4 (2016): 483-488. [00:19:01] Lucy Mailing. [00:19:54] Lactobacillus reuteri. [00:21:24] Age-related macular degeneration. [00:23:06] Podcast: How to Avoid Kidney Stones with Dr Lynda Frassetto. [00:15:30] Podcast: How to Have a Healthy Gut, with Dr. Michael Ruscio. [00:24:47] Podcast: Getting Stronger, with Todd Becker; hormesis. [00:25:36] Getting Stronger blog. [00:25:51] XPT Life. [00:27:18] Setting up a chest freezer cold bath. [00:29:07] Laird Hamilton and Gabby Reece. [00:31:12] Podcast: NBT People: Clay Higgins. [00:31:23] Podcast: How Oxidative Stress Impacts Performance and Healthspan. [00:31:46] Dr. Josh Turknett, Ancestral Health Symposium 2014 talk: Migraine as the Hypothalamic Distress Signal. [00:32:37] Mymigrainemiracle.com. [00:36:54] Strategy for avoiding migraines. [00:40:37] Book: The Migraine Miracle; mymigrainemiracle.com; Facebook group; The Miracle Moment Podcast, membership community. [00:41:54] Keto Blast. [00:42:49] Tommy's AHS 2018 talk: The Athlete's Gut. [00:45:47] Hadza studies: 1. Raichlen, David A., et al. "Physical activity patterns and biomarkers of cardiovascular disease risk in hunter‐gatherers." American Journal of Human Biology 29.2 (2017): e22919; 2. Pontzer, Herman, et al. "Energy expenditure and activity among Hadza hunter‐gatherers." American Journal of Human Biology 27.5 (2015): 628-637. [00:48:31] Effect of intense exercise on the gut; Study: van Wijck, Kim, et al. "Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention." American journal of physiology-gastrointestinal and liver physiology 303.2 (2012): G155-G168. [00:49:32] Paula Radcliffe. [0:49:59] Fueling for endurance events. [00:51:15] Protein intake after workouts; Study: Aragon, Alan Albert, and Brad Jon Schoenfeld. "Nutrient timing revisited: is there a post-exercise anabolic window?." Journal of the international society of sports nutrition 10.1 (2013): 5. [00:54:13] Exercise for health and longevity. [00:55:12] Polarized training; MAF pace, sprints. [00:56:53] Undereating; ancestral athletes. [00:59:30] Adding carbs back in. [01:01:09] Gut dysbiosis and pathogens. [01:02:02] Parasites on lettuce: Chierico, Del. "Detection and prevalence of protozoan parasites in ready-to-eat packaged salads on sale in Italy." Food microbiology (2017). [01:02:13] Sebastian Winter. [01:05:36] Gut microbiota of cyclists; Study: Petersen, Lauren M., et al. "Community characteristics of the gut microbiomes of competitive cyclists." Microbiome 5.1 (2017): 98. [01:05:48] Lauren Petersen Podcasts: The Athlete Microbiome Project: The Search for the Golden Microbiome and An Update on The Athlete Microbiome Project. [01:05:52] Methane dominant SIBO; Methanobrevibacter smithii. [01:07:02] Book: The Brave Athlete: Calm the F*ck Down and Rise to the Occasion, by Simon Marshall and Lesley Paterson (audible version here). [01:07:56] Podcast: How Busy Realtors Can Avoid Anxiety and Depression Without Prescriptions or the Help of a Doctor, with Doug Hilbert. [01:08:01] Podcast: How to Reverse Insulin Resistant Type Two Diabetes in 100 Million People in Less Than 10 Years with Jim McCarter. [01:10:11] Virta Health. [1:20:04] Pain as motivation to change. [01:24:00] www.virtahealth.com. Apply to Virta Health.