POPULARITY
3 episodes with Elastin
2 episodes with Elastin
2 episodes with Elastin
2 episodes with Elastin
2 episodes with Elastin
2 episodes with Elastin
▶️ Connect with Richard on LinkedIn: https://www.linkedin.com/in/richardatherton-firsthuman/ This week, I sit down with Douglas Mulhall, author of the bestselling book Discovering the Nature of Longevity: Restoring the Heart and Body by Targeting Hidden Stress. Douglas has spent over 30 years creating products that are not only good for people but also the environment, with significant contributions in collaboration with European governments. We take a deep look at elastin, a major area of interest for Douglas. It's a vital protein key to your body's resilience. Elastin is in more than 30 organs. It's in your arteries. It's essential for everything in your body to expand and contract. We talk: Elastin defined The tragedy that spurred his quest The story of calcification How to reverse the hardening of our bodies Hope for a heart disease breakthrough Links: Discovering the Nature of Longevity - The Book Douglas' Website If you're curious about unlocking your body's potential, this episode is an absolute must-watch! Don't miss out—subscribe for more thought-provoking conversations about what it means to be human.
What does it take for a founder to break new ground in an industry full of barriers and taboos? This episode of The Angel Next Door Podcast features Colette Courtion, CEO and founder of JoyLux, whose personal experience ignited a mission to transform women's health with innovative, red light therapy solutions for intimate wellness.Colette shares how JoyLux was born from her own postpartum and perimenopausal struggles, leading her to bring a groundbreaking device to market—despite hurdles like FDA delays, social media restrictions, and the lack of investment in women's healthcare. She reveals what it was like to gain celebrity support from Halle Berry, as well as how the company weathered the pandemic and navigated tough challenges like rising tariffs and scaling internationally.This is a must-listen for anyone interested in entrepreneurship, women's health, and the power of combining personal passion with resilient leadership. Colette's story offers relatable lessons on perseverance and the importance of being bold in the pursuit of change.To get the latest from Colette Courtion, you can follow her below!https://www.linkedin.com/in/colettecourtion/ https://joylux.com/ Sign up for Marcia's newsletter to receive tips and the latest on Angel Investing!Website: www.marciadawood.comLearn more about the documentary Show Her the Money: www.showherthemoneymovie.comAnd don't forget to follow us wherever you are!Apple Podcasts: https://pod.link/1586445642.appleSpotify: https://pod.link/1586445642.spotifyLinkedIn: https://www.linkedin.com/company/angel-next-door-podcast/Instagram: https://www.instagram.com/theangelnextdoorpodcast/TikTok: https://www.tiktok.com/@marciadawood
Think collagen is the ultimate key to youthful skin and health? Think again. In this episode, Douglas Mulhall, author of *Discovering the Nature of Longevity,* breaks down why elastin might just be the unsung hero in anti-aging. From its role in keeping your skin supple and arteries flexible to cutting-edge nanoparticle therapies that restore it, we're diving deep into the science of staying young. We also explore how hidden stresses, toxic metals, and lifestyle choices impact elastin and what you can do to enhance your longevity. If you're serious about understanding what really keeps you young, this is an episode you can't miss! BUY ME A COFFEE LINK https://buymeacoffee.com/sensiblehippie If you like to be on the show or have guest suggestions please email me sensiblehippie@gmail.com https://www.instagram.com/sensiblehippie/ https://www.facebook.com/SensibleHippie https://lvnta.com/lv_IcTq5EmoFKaZfJhTiS USE DISCOUNT CODE: OHANA FOR 20% OFF Beginning music from Moments: Fugue Frenzy Intro music: PALA: Summertime Midtro: Cody Martin: Pemberley Outro music: The Moment: Adrian Walther End Music: Lunareh: At First Light End Song: Scarlett: Dare to Live Final Song: Lucy Domino: Me ✨ Join My Free Patreon! Sign up for free to enjoy ad-free episodes and access any content that couldn't make it onto YouTube due to policy restrictions. It's the best way to stay connected and never miss the full story!Patreon.com/WAKEUPWITHMIYA
In this episode, Dr. Joseph Hkeik and Bahar Etminan discuss advancements in aesthetic treatments, with a particular focus on Sofwave technology. The conversation delves into the importance of multimodal approaches to treatment, the role of collagen and elastin in maintaining skin health, and the ideal candidates for Sofwave therapy. Key themes include the significance of holistic beauty practices, the impact of hormones on skin ageing, and the comfort and experience of the treatment process. Dr. Hkeik highlights the importance of addressing underlying causes of skin and ageing concerns through a holistic approach to aesthetic medicine. He explains the effects of menopause on bone density and skin elasticity, the value of tailored treatments, and the necessity of treating the entire face rather than isolated areas. The episode also explores the integration of wellness into aesthetic practices, the rise of regenerative medicine, and the increasing interest in aesthetic treatments for men. This episode is in partnership with High Tech Medical. Takeaways Technology is a transformative tool in aesthetic treatments. Sofwave technology offers a non-invasive solution for skin tightening. Collagen and elastin are vital for youthful skin. Sofwave therapy is ideal for those with mild to moderate skin elasticity concerns. Holistic beauty approaches yield better long-term outcomes. Combination therapies enhance treatment effectiveness. Hormonal changes significantly impact skin health and appearance. Treatment comfort is critical for client satisfaction. Advances in technology are making aesthetic treatments more accessible. Aesthetic plans should be personalised and adaptable. Addressing root causes is essential in skin and ageing treatments. Menopause affects bone density and facial structure. Hormonal changes deteriorate skin elasticity. Tailored treatments deliver the most natural results. Treating the full face is more effective than addressing isolated areas. Aesthetic medicine requires artistic skill for achieving balance. Combining treatments boosts results and efficiency. More men are exploring aesthetic treatments. Integrating wellness and regenerative medicine represents the future of aesthetics. Chapters00:00 Exploring Multimodality in Aesthetic Treatments02:56 Understanding Sofwave Technology06:13 The Role of Collagen and Elastin in Skin Health09:08 Identifying Ideal Candidates for Sofwave Therapy11:58 Holistic Beauty and Combination Therapies15:06 The Impact of Hormones on Skin Ageing17:50 Comfort and Experience During Treatment24:21 Holistic Approaches to Aesthetic Medicine27:31 Understanding Ageing: Bone Density and Skin Changes29:08 The Importance of Tailored Treatments32:30 Spot Treatments vs. Full Face Treatments35:52 The Art of Facial Aesthetics38:37 Combining Treatments for Optimal Results40:06 Men and Aesthetic Treatments42:49 The Future of Regenerative Medicine47:35 Integrating Skin Wellness into Aesthetic Practices Watch the full episode here:https://youtu.be/SRvI6rOaxok See omnystudio.com/listener for privacy information.
What is the Elastic of Life? We're thrilled to welcome Douglas Mulhall, journalist, author, award-winning documentary filmmaker, and co-founder of Elastrin Therapeutics. Douglas shares the latest developments in elastin research and its potential role in reversing cardiovascular damage and treating aneurysms. Tune in to discover how this innovation may transform heart health and help people live longer, healthier lives. Don't miss this in-depth conversation on a revolutionary approach to cardiovascular care! ElastinTherapy #AneurysmTreatment #HeartHealth #HealthyAging #CardiovascularHealth #Longevity www.natureoflongevity.com Timeline 02:40 Elastin – the elastic of life 04:40 Elastin & Collagen are woven together 07:40 Elastin production stops at age 30 10:50 Aneurysm 13:20 Cross linking 15:00 Oxidative stress 16:20 Toxic metals & hardening of arteries 19:10 Chelation therapy 26:30 PGG 32:40 Neo Lastin 37:00 Elastin for wound healing 42:00 Reversing senescence The Yakking Show is brought to you by Peter Wright & Kathleen Beauvais contact us to be a guest on our show. https://TheYakkingShow.com peter@theyakkingshow.com kathleen@theyakkingshow.com Join our community today so you don't miss out on advance news of our next episodes. https://bit.ly/3JW9w46 Here are some of the tools we use to produce this podcast. Hostgator for website hosting. Podbean for podcast hosting Airtable for organizing our guest bookings and automations. Spikers Studio for video editing Clicking on some links on this site will let you buy products and services which may result in us receiving a commission, however, it will not affect the price you pay.
The discussion of collagen is often focused on beauty - hair, skin, and nails - but collagen is vitally important for all of the connective tissues in the body, as well as bone! On this episode of Vitality Radio Jared invites Richard Passwater back to the show and they focus on the role of silica in collagen production, and specifically how this pertains to joint and bone health. They explore how BioSil, a specific form of silica, enhances the body's ability to produce collagen and maintain healthy connective tissues. The conversation delves into the mechanisms of collagen turnover, the significance of cofactors, and the impact of movement on joint health. You'll learn also about the essential nutrients required for optimal collagen production, including vitamin C, iron, and protein. The discussion also contrasts BioSil with collagen supplements, highlighting their unique roles in the body. Products:BioSilNatural Factors Total Body CollagenVitamin CIron BisglycinateAdditional Information:#303: Collagen, How We Make It, Why We Need It, and How to Build More With SilicaThe Science Behind BioSilVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Dr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases. Sherif explains, "One of the hallmarks of aging is the loss of the extracellular matrix, which is composed of several proteins. Collagen is quite famous, but also elastin is the other major protein that is responsible for the elasticity of the different organs. For example, in our skin, the loss of elastin is associated with us looking older and having all the aging signs and wrinkles on the skin. If you imagine that there are other organs inside that we don't visually see, then you have also the blood vessels, the lungs, a lot of the connective tissue. The extracellular matrix proteins and elastin itself are also aging in the same way and have their own form of damage one way or another. All of this contributes to aging and aging-related diseases as well." "Another kind of disease is the category of rare diseases. In this case, we aim to target Williams syndrome, a rare disease characterized by a genetic partial deletion of around 26 genes. One of these genes is elastin itself, so some genetic material is still there, but there is not enough. We would like to try to push the elastin production up in Williams syndrome, and this would help rectify a lot of the disease issues, particularly when it comes to the cardiovascular system because Williams syndrome patients have quite a lot of issues with the cardiovascular system from birth and all through life." #ElastinBiosciences #Aging #AgingRelatedDiseases #Elastin #WilliamsSyndrome elastin-biosciences.com Download the transcript here
Dr. Sherif Idriss is the CEO of Elastin Biosciences, a company focused on targeting aging-related diseases by restoring elastin, a key protein in the extracellular matrix that provides elasticity and resilience to organs and tissues. They are developing small molecule therapies for diseases linked to elastin deficiency, including Williams syndrome and abdominal aortic aneurysm. As elastin degrades over time due to aging, it leads to loss of tissue structural integrity and function, contributing to numerous age-related diseases. Sherif explains, "One of the hallmarks of aging is the loss of the extracellular matrix, which is composed of several proteins. Collagen is quite famous, but also elastin is the other major protein that is responsible for the elasticity of the different organs. For example, in our skin, the loss of elastin is associated with us looking older and having all the aging signs and wrinkles on the skin. If you imagine that there are other organs inside that we don't visually see, then you have also the blood vessels, the lungs, a lot of the connective tissue. The extracellular matrix proteins and elastin itself are also aging in the same way and have their own form of damage one way or another. All of this contributes to aging and aging-related diseases as well." "Another kind of disease is the category of rare diseases. In this case, we aim to target Williams syndrome, a rare disease characterized by a genetic partial deletion of around 26 genes. One of these genes is elastin itself, so some genetic material is still there, but there is not enough. We would like to try to push the elastin production up in Williams syndrome, and this would help rectify a lot of the disease issues, particularly when it comes to the cardiovascular system because Williams syndrome patients have quite a lot of issues with the cardiovascular system from birth and all through life." #ElastinBiosciences #Aging #AgingRelatedDiseases #Elastin #WilliamsSyndrome elastin-biosciences.com Listen to the podcast here
Tired of hearing the same old explanations about worry lines and wrinkles? In this episode, we challenge conventional wisdom and dive into a fascinating, nature-based perspective on why these lines form. Forget about collagen and elastin for a moment. We'll explore how your forehead functions like a river system, and how understanding this can revolutionize your approach to facial care. Discover how Gua sha can revitalize this system and help smooth those worry lines. Join us as we unravel the secrets behind your forehead's unique landscape, and learn how to harness the power of Facial Gua sha for a more natural, holistic approach to anti-aging.
In this Mini Pause®, Jenna examines how and why the skin changes during peri and post-menopause and what you can do about it.TakeawaysPerimenopause and post-menopause is a time of massive skin changes.What can happen to the skin as estradiol declines during peri and post-menopause.How we can offset the changes we find troublesome.Chapters00:00 Introduction01:02 A Time Of Massive Skin Changes01:43 The Estrogen Factor02:16 Skin Density, Plumpness & Hydration04:09 What Are Collagen & Elastin?05:30 What Is Hyaluronic Acid?07:20 Argh:!Dehydration, Sensitivity, Crepey Skin, Itchy Skin, Pigmentation & Acne12:54 Skin 10114:33 The Layers Of The Skin17:20 15 Ways To Look After Your Skin During Peri & Post-MenopauseEpisode Resources:Read: 6 Ways To Tame Itchy Skin hereRead: How To Soothe Ichy Skin (including your va-jay-jay) hereRead: How To Have Fabulous Skin After The Age 40 hereListen: The Impact Of EDC's & Xenoestrogens On Menopause hereWatch: How Gut Health Affects Your Menopause Journey hereHappy Go Tummy® hereLotsaLocks® hereWomen On Fire® is sponsored by MenoMe®Follow MenoMe® on Instagram hereFollow MenoMe® on Facebook hereVisit the website hereSubscribe to the YouTube channel to watch the interviews here We're honoured you've joined Women On Fire® and hope you enjoyed this episode. If you did, we would be grateful if you would leave us a review wherever you listen to your podcasts or subscribe to our YouTube channel. That way, we can reach as many women as possible with Women On Fire®.Disclaimer: Our Mini Pauses® are for information purposes only. They come from a holistic vantage point and from collating (often conflicting) scientific data if it's available. They should not take the place of medical advice.menoverse, peri, menopause, postmenopause, midlife, millennopause, millennials, perimenopause, hormonal changes, symptoms, post-menopauseHosted by Ausha. See ausha.co/privacy-policy for more information.
Our diet is a key component that can add to our aging.Did you know that sugar can cause "Skin Sugar Sag"?In this episode, Dr. Saluja and Kane explore how sugar consumption can significantly impact skin health through a process known as glycation. This occurs when excess sugar molecules attach themselves to collagen and elastin, the proteins that keep skin firm and elastic. Over time, this reaction forms harmful new molecules known as Advanced Glycation End-products (AGEs). AGEs accumulate, leading to the breakdown of collagen and elastin, resulting in skin that appears less firm and more wrinkled—a phenomenon often referred to as "sugar sag." Reducing sugar intake can help mitigate this process, preserving skin's youthful appearance and maintaining its structural integrityThank you for your listenership!
Douglas Mulhall returns to talk about epigenetics which is the study of how the environment and other factors can change the way that genes are expressed. We learn about multi-generational epigenetics and discover that the nature versus nurture debate is not a debate at all. Douglas is a journalist, author and award-winning documentary filmmaker. He co-founded Elastrin Therapeutics, dedicated to reversing cardiovascular damage. He specializes in helping people live long healthy lives. https://natureoflongevity.com The Yakking Show is brought to you by Peter Wright & Kathleen Beauvais contact us to be a guest on our show. https://TheYakkingShow.com peter@theyakkingshow.com kathleen@theyakkingshow.com Join our community today so you don't miss out on advance news of our next episodes. https://bit.ly/3JW9w46 Timeline 01:40 What is Epigenetics? 04:50 Mult-generational epigenetics 08:30 Reversing epigenetic effects 09:30 DNA Methylation 12:30 Heavy Metals 16:40 Transhumanism 18:30 Perplexity & AI bots 20:50 Exercise 23:20 AI services for medical research 31:50 Elastin fibre 32:50 The Elastin clock 35:20 Epigenetics & Mental Health 39:12 Health tip – Learn about epigenetics 40:00 Contact Douglas Here are some of the tools we use to produce this podcast. Hostgator for website hosting. Podbean for podcast hosting Airtable for organizing our guest bookings and automations. Audio Pen for transcribing voice notes Clicking on some links on this site will let you buy products and services which may result in us receiving a commission, however, it will not affect the price you pay.
I get asked all the time what is the best thing for collagen so here are my tips tips across diet, nutrition, skincare products and treatments. Enjoy
Join us on The Yakking Show for an exclusive interview with Douglas Mulhall, journalist, author, and co-founder of Elastrin Therapeutics. Learn firsthand from an expert dedicated to reversing cardiovascular damage and promoting long, healthy lives. Discover valuable insights on improving cardiovascular health, achieving radiant skin, and reducing overall stress. Find out why our immune systems turn against us as we age. Don't miss out on this transformative discussion! #HealthTalk #CardiovascularHealth #Wellness www.natureoflongevity.com The Yakking Show is brought to you by Peter Wright & Kathleen Beauvais contact us to be a guest on our show. https://TheYakkingShow.com peter@theyakkingshow.com kathleen@theyakkingshow.com Join our community today so you don't miss out on advance news of our next episodes. https://bit.ly/3JW9w46 Timeline 01:40 Why focus on longevity? 03:40 Can we live to 100? 05:00 Our immune systems turn on us as we age 07:20 What is Elastin? 11:10 Aneurisms 17:00 Collagen 18:40 Elastin could reverse skin damage 20:00 Heavy metals 24:30 Calcium 26:40 Discovering the Nature of Longevity – book 29:50 Epigenetics 35:00 Contact Douglas Here are some of the tools we use to produce this podcast. Hostgator for website hosting. Podbean for podcast hosting Airtable for organizing our guest bookings and automations. Audio Pen for transcribing voice notes Clicking on some links on this site will let you buy products and services which may result in us receiving a commission, however, it will not affect the price you pay.
Introducing Sofwave, our latest breakthrough device at the forefront of skin transformation. Harnessing the power of ultrasound technology and radiofrequency energy, Sofwave tightens skin, boosts collagen and elastin, and enhances skin texture. This non-invasive solution offers zero downtime, allowing you to return to your workouts and makeup routine immediately. Suitable for all skin types, this revolutionary treatment is the key to a transformed body. Join us as our doctors, nurses, and aestheticians discuss this treatment and why they are so excited to add this to their practice. Tune in for our discussion with the team as they share their excitement about the benefits of Sofwave and what it can bring to patients.
Selamlar! Bu hafta menümüzde elastin konusu var. Kolajen gibi yapısal bir protein olan elastinin aslında oldukça önemli görevleri var. Tam da İngilizce'de underrated denen ve aslında gereğinden az değer gördüğünden bahsedebileceğimiz bir konu elastin.. Solunumdan cilt üzerindeki etkilerinde kadar geniş bir yelpazede değerlendirebileceğimiz bu konuya gelin biraz daha yakından bakalım. Keyifli dinlemeler! Elastin Bozuklukları | Makale | Türkiye Klinikleri (turkiyeklinikleri.com)
Die vielen Gesichter des Kollagens: Von Anti-Aging bis zur Unterstützung bei Gelenkschmerzen Kollagen ist eines der Mittel, das im Zusammenhang mit Anti-Aging, aber auch mit Beauty immer wieder auftaucht. Aber was ist Kollagen genau, wofür ist es gut, was hat es mit der Darmgesundheit zu tun? Kann man es auf natürlichem Weg zu sich nehmen oder braucht es tatsächlich eins der zahlreichen Nahrungsergänzungsmittel dazu? Diesen Fragen und noch weiteren gehe ich in dieser Folge nach. In dieser Folge gebe ich Antworten auf die Fragen
This episode dives deep into palmitoyl-pentapeptide-4 known as matrixyl. We go through skin anatomy and explore the various cells that create vital skin proteins like keratin, collagen, and elastin. Furthermore, we explore hyaluronic acid, what it does on the cellular level, how it's produced and by which cells, and how matrixyl stimulates its production. We finish the conversation with a compare and contrast session that details some of the hallmarks of skin aging along with the peptides that might be useful and why. Topics: 1. Introduction - Review of GHK-Cu peptides from previous episode (42) - Overview of matrixyl as a skin-supporting peptide - General use cases of each peptide for skin health and appearance 2. Comparing GHK-Cu and Matrixyl - GHK-Cu: - Suited for mature skin or skin in need of repair - Useful for both aging and inflammatory skin concerns - Matrixyl: - Targeted for fine lines and wrinkles - Differences in how they function within the body and their respective results 3. The Epidermis - Stratum Corneum: Outermost layer; dead, flattened keratinocytes filled with keratin; lipid matrix for hydration - Stratum Lucidum: Found in thicker skin regions; additional keratinocytes for protection - Stratum Granulosum: Active keratin production and accumulation in keratinocytes - Stratum Spinosum: Younger keratinocytes; Langerhans cells for immunity - Stratum Basale: Basal keratinocytes reproduction; melanocytes for melanin and Merkel cells for touch sensation 4. The Dermis - Papillary Dermis: Thin collagen and elastin fibers; blood and lymphatic vessels; Langerhans cells' immune defense pathway - Reticular Dermis: Denser collagen and elastin due to higher fibroblast concentration; sebaceous and sweat glands, hair follicles, mast cells 5. Matrixyl's Role in the Skin - Definition and breakdown of matrixyl as a palmitoyl pentapeptide-4 - Mechanism of action: How matrixyl functions in the skin - Penetration through the lipid matrix - Activation of fibroblasts to produce collagen and elastin - Stimulation of hyaluronic acid (HA) production 6. Aging and Skin - Impact of decreasing collagen and HA as one ages - Differences between the effects of reduced collagen and HA on the skin 7. Study on Matrixyl's Efficacy - Study overview: Double blind study on matrixyl's effects on periocular wrinkles - Results: Quantitative decreases in wrinkle depth, thickness, and rigidity over 28 days Thanks so much for tuning in! Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
This episode dives deep into the anatomy of the skin including it's cellular makeup and the important proteins and lipids produced by these skin cells. Then, we explore copper peptides, what they do to these fibroblasts and keratinocytes (skin cells). And, finally, we go through my n=1 experiment and examine how I make a skincare serum using GHK-Cu. This episode is where science meets peptides meets skincare! You won't want to miss it! Topics: 1. Introduction - Overview of the skincare discussion surrounding copper peptides. 2. Anatomy of the Skin - Brief description of the skin's multi-layered structure and its essential role. - Epidermis: Description of the outermost protective shield. - Stratum corneum: The outermost layer of the epidermis. - Stratum lucidum: Only found in the palms and soles. - Stratum granulosum: Maturing keratinocytes. - Stratum spinosum: Contains several layers of keratinocytes. - Stratum basale: Deepest layer with keratinocyte production. - Summary of the epidermis sublayers and their functions. - Dermis: Two distinct sublayers. - Papillary dermis: Uppermost layer, interlocking with the epidermis. - Reticular dermis: Dense, deep layer providing skin elasticity and strength. - Discussion on crucial skin components: - Keratin and keratinocyte-derived lipids: Their roles and importance. - Collagen: Its role in skin health and appearance. - Elastin: Essential for skin's elasticity and resilience. 3. Skin-Aging and Cosmetic Peptides - Delving into the aging process of the skin. - Aging effects: How they manifest and the science behind them. - Introduction to cosmetic peptides: Their increasing role in skincare. - Copper's significant role in skin health. - How copper stimulates dermal fibroblasts. - Copper's role in collagen and elastin production. - How copper stabilizes the dermal extracellular matrix. - A deeper dive into copper peptides: AHK-Cu and GHK-Cu. - Their general properties and amino acid structure. - The biological activities associated with these peptides. - AHK and GHK's specific roles in skin health and regeneration. - A comparison between AHK and GHK. 4. Personal Experimentation with Copper Peptides - A detailed example: Formulating a skincare product with 1% GHK-copper peptide serum. - Steps and ingredients to formulate the serum - pH compatibility 5. Conclusion - Consulting a licensed physician before beginning any skincare regimen. - Emphasizing the significance of personal experimentation and observation. Thanks so much for tuning in! Pre-Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
LPG-Ausbilderin Silvia Groser erklärt im Interview, warum mit zunehmendem Alter Falten entstehen und welche Rolle Kollagen, Hyaluronsäure und Elastin bei der Faltenbildung spielen. Sie informiert zudem darüber, was man gegen Falten tun kann und welche nicht-invasiven Methoden es gibt, um die Haut zu straffen. Dazu stellt sie die Behandlung endermologie® von LPG vor. Mehr dazu unter https://www.balancebeautytime.com/beauty/falten-reduzieren-ohne-op Diese Sendung enthält Produktplatzierungen.
In this episode of the "No Sitting on the Sideline Dad" podcast, we welcome Douglas Mulhall, a seasoned expert in the field of Environmental Health. With over 30 years of experience, Mulhall shares his unique insights into how our environment impacts our health and how our health, in turn, impacts the environment. One of the key topics we delve into is the issue of antimicrobial resistance, a significant environmental health concern. Mulhall explains how the overuse of drugs in humans and animals has led to microbes and viruses becoming resistant to therapies, posing a serious threat to global health. Inspired by his father's death from heart disease, Mulhall has developed a keen interest in the role of inflammation in heart disease. He sheds light on the function of elastin, a crucial protein in the human body that degrades over time and is not replaced, leading to an inflammatory response in the body. We also discuss the potential of new therapies to repair elastin, which could potentially reverse heart disease. While these therapies are still in the experimental stage, they hold promise for the future of heart disease treatment. Mulhall recommends a couple of tests that can be done to detect early signs of heart disease: the Carotid Intima-Media Thickness Test (CIMT) and the Coronary Artery Calcium (CAC) score. He also mentions a nutraceutical product called Nano BacTX, which has been on the market for 20 years and has been endorsed by several high-level cardiologists. Finally, we explore the benefits of a plant-based diet as a way to reduce inflammation in the body and potentially reverse heart disease. This episode is packed with valuable insights and practical advice, making it a must-listen for anyone interested in health and wellness. DOUGLAS MULHALL BOOKS BOOKS Website : www.natureoflongevity.com
Our Third Monday of the month is our ‘Oils A-Z' episode. This week our Leader practitioners will be sharing a deep dive into Lemon: the oil of Focus. Initial BOGO Tips: Neroli, besides supporting hormones, beautiful skin, and soothing mood, also helps with cramping pain: wonderful for menstrual and digestive support Davana is like a mood ring! Changing with each person's chemistry Brightening Gel is a high-end Vitamin C facial serum Diffuse Island Mist in Hot summer environments to help keep cool Lemon is no ordinary oil! Learn more about the Physical uses for cleansing with d-limonene: cuts through Gunk! Daily tonic in water, but also Try in shampoo, breaking up solid gunk, like stones, blood pressure support, And learn how lemon's ability to move & clear would help with pain and inflammation. Understand Dr. Mica's Analogy of Hormone imbalance with brain fog to a Louisiana Bayou- steamy, hot, boggy, and gunky- And how Lemon is the Empress Oil for this! How Lemon facilitates our Liver Actions with Phase II Detoxification Slows down the enzyme that breaks down our Skin's Elastin! (Only use at night) Supports the healthy balance of White & Red Blood cells = supporting our immune system Understand Why we say Lemon is the oil of uplifting, abundance, clearing, and movement of all stagnation This oil comes from the Pith/Peel/Pi - in Chinese Medicine, this clears Liver Qi stagnation. Supports our Ligaments & Tendons elasticity by easing Liver Qi stagnation Lemon on LV3 & GB 34 Learn how you can support an anxious indecisive “mama Hoohoo” state with Lemon!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.15.532834v1?rss=1 Authors: Howell, J. A., Gaouette, N., Lopez, M., Burke, S. P., Perkins, E., Bidwell, G. L. Abstract: Inflammatory processes are activated following ischemic strokes and lead to increased tissue damage for weeks following the ischemic insult, but there are no approved therapies that target this inflammation-induced secondary injury. Here, we report that SynB1-ELP-p50i, a novel protein inhibitor of the nuclear factor kappa B (NF-{kappa}B) inflammatory cascade bound to drug carrier elastin-like polypeptide (ELP), is able to enter both neurons and microglia, cross the blood-brain barrier, localize exclusively in the ischemic core and penumbra in Wistar-Kyoto and spontaneously hypertensive rats (SHRs), and reduce infarct volume in male SHRs. Additionally, in male SHRs, SynB1-ELP-p50i treatment improves survival for 14 days following stroke with no effects of toxicity or peripheral organ dysfunction. These results show high potential for ELP-delivered biologics for therapy of ischemic stroke and other central nervous system disorders and further support targeting inflammation in ischemic stroke. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Collagen và Elastin là gì và chúng có vai trò cụ thể gì đối với làn da? Để có một làn da khỏe mạnh và săn chắc thì việc bổ sung Collagen cũng như Elastin là điều vô cùng cần thiết. Đây là hai yếu tố rất quan trọng đối với làn da và được ví như bộ khung chống đỡ bên dưới da, giúp da luôn căng mịn và có tính đàn hồi. Collagen là gì? Collagen là dưỡng chất được biết đến nhiều trong vai trò làm đẹp cho da, giúp da duy trì được vẻ căng bóng, săn chắc đồng thời ngăn ngừa tình trạng lão hoá sớm trên da. Thực chất, cả Elastin và Collagen đều đóng những vai trò cực kỳ quan trọng trong việc duy trì sự khỏe mạnh của các bộ phận trong cơ thể. Tuy nhiên, bộ đôi protein này có phần thể hiện rõ hơn chức năng của mình đối với việc chăm sóc làn da, đặc biệt là công dụng tích cực đối với việc chống lão hóa da giúp duy trì sự căng mịn, đàn hồi, tươi sáng của làn da.#nguyenngocduy #hebora #heboracollagen #heboravnXem thêm: https://hebora.vn/collagen-va-elastin-la-gi.html Hosted on Acast. See acast.com/privacy for more information.
Có những cách bổ sung Elastin nào? Khi nhắc đến việc chăm sóc da, cải thiện tình trạng lão hoá, hầu hết mọi người chỉ nghĩ đến việc bổ sung Collagen mà vô tình quên mất Elastin cũng là một dưỡng chất quan trọng không kém, góp phần làm nên làm da săn chắc, tươi trẻ. Vậy Elastin là gì? Elastin là một chất có đóng vai trò rất quan trọng trong việc chống đỡ cấu trúc da cũng như làm tăng độ đàn hồi ở ra. Thực chất đây là một loại protein gần giống với collagen, được tìm thấy nhiều ở những mô liên kết. Chúng có tính đặc tính đàn hồi và có khả năng kết nối các tế bào lại với nhau từ đó giúp da căng bóng và săn chắc hơn. Tại sao phải bổ sung Elastin? Cùng với sự lão hoá tự nhiên của cơ thể, hàm lượng protein cũng theo đó giảm dần theo thời gian, kéo theo sự sụt giảm của Elastin và Collagen. Làm thế nào để tăng cường Elastin cho da? Bài viết sau đây sẽ hướng dẫn bạn các cách vừa đơn giản lại hiệu quả.#nguyenngocduy #hebora #heboracollagen #heboravnĐọc thêm: https://hebora.vn/cach-bo-sung-elastin.html Hosted on Acast. See acast.com/privacy for more information.
Richard Dawkins discusses the elasticity of elastin and prestissimo keyboard keys.
In this episode, we review the high-yield topic of Elastin from the Biochemistry section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbulletsIn this episode --- Send in a voice message: https://anchor.fm/medbulletsstep1/message
It's important to recognize your skin as the window to your body. What you do throughout each day will be reflected in the way your skin appears. Chris Gibson, a holistic health expert, and I discuss several considerations on the show today for helping our largest organ stay healthy.What you eat is just as important as what you put on your skin. Reducing your stress level is also paramount to having a glowing complexion. Consider taking time in nature or doing tai chi, meditation or yoga as ways to reduce stress.Collagen and Elastin are the new buzzwords today because these products give skin it's strength and elasticity which we lose with age. In addition to keeping our skin more supple, collagen peptides help with aging joints, bone strengthening and hair and nail growth.People who are having sleep problems will also show signs of skin aging as well as a lessening of the ability for the skin to repair itself at night due to the environmental stressors of the day.This show will help you examine areas in your daily life where you can make changes and protect the outer package we call our skin.Chris Gibson can be reached via the following links:ChrisGibsonLive on YouTubeSkin So Fabulous
Injectable and laser specialist Anh Bridgewater, PA-C has an uncanny ability to make each patient feel as if they are her only one. Find out which procedures Anh believes make the biggest difference for the face and the number one skin care product she would recommend to almost everyone. Like everyone at LJC, Anh's patients are her top priority. Her ability to coordinate and collaborate with both our plastic surgery and skin care teams makes her an excellent addition to the LJC team. Links Read more about Anh Bridgewater, PA-C https://www.ljcsc.com/about/meet-the-team/medical-spa-providers/anh-bridgewater-pa-c/ Follow Anh on Instagram @anhthebeautypa https://www.instagram.com/anhthebeautypa/ Take a screenshot of this podcast episode with your phone and show it at your consultation or appointment, or mention the promo code PODCAST to receive $25 off any service or product of $50 or more at La Jolla Cosmetic. La Jolla Cosmetic is located just off the I-5 San Diego Freeway at 9850 Genesee Ave, Suite 130 in the Ximed building on the Scripps Memorial Hospital campus. To learn more, go to https://www.ljcsc.com/ or follow the team on Instagram at @ljcsc https://www.instagram.com/ljcsc/ The La Jolla Cosmetic Podcast is a production of http://www.theaxis.io/ Special Guest: Anh Bridgewater.
From double chins to turkey necks, the neck can be a frustrating reminder that we can't always hide the effects of aging. Our skin is an amazing organ. Despite the daily environmental damage it takes during our youth, it holds up pretty well. But by the time we reach 30, the years of accumulated damage begin to affect this skin on a cellular level, and subtle visual and tactile changes start to show up. At first, skin under the chin looks okay, but feels a little loose. Then by our 40s, there begins to be a little visual sagging. And by 50, what the f#(&, where did that come from? Analogous to a rubber band that gets repeatedly overstretched, our skin ultimately loses its snap, and there is no other area on the body that undergoes the constant movement of the neck and jawline. As we get older, collagen, which is what gives our skin its structural support, begins to break down, and the skin thins out and deflates. Elastin, which are the elastic recoil fibers, breakdown and the skin loses its snap and the big hang begins. Dr. Grossman welcomes Dr. Andrew Ordon, world-renowned cosmetic surgeon and co-host of the Emmy award-winning talk show, The Doctors to discuss intricacies and benefits of getting rid of those double chins and turkey necks. Learn More About the Host of Beauty and the BS Dr. Peter Grossman Follow Dr. Grossman on Instagram @dr.petergrossman
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Core Pathways of Aging, published by johnswentworth on the LessWrong. Most overviews of aging suffer from multiple problems: They dump a bunch of findings with no high-level picture. Many of the claims they make are outdated, purely theoretical, and sometimes even outright disproven by existing work. They are usually written by working academics, who are shy about telling us when their peers' work is completely wrong. They are shy about making strong claims, since this would also implicitly mean denying some claims of the authors' peers. This post is a high-level brain-dump of my current best models of the core pathways of aging, as I currently understand them. I have no particular reason to avoid calling out claims I think are wrong/irrelevant, and I'm going to present high-level models without pages and pages of disclaimers and discussions about results which maybe disagree with them (but are probably just wrong/irrelevant). Epistemic status: I would be surprised if none of it turned out to be wrong, but there are multiple lines of evidence supporting most claims. It is not highly polished, and references are included only when I have them readily on hand. My ideal version of this piece would have more detailed references, more double-checking behind the claims, and more direct presentation of the data which backs up each claim. Unfortunately, that would take enough time and effort that I'm unlikely to actually get to it soon. So. here's what I could produce in a reasonable amount of time. Hopefully it will be wrong/unhelpful in ways orthogonal to how most overviews are wrong/unhelpful. Foundations First, let's recap a couple foundational principles. I'll go through these pretty quickly; see the linked posts for more info. Homeostasis and “Root Causes” in Aging: the vast majority of proteins, cells, etc, in the human body turn over on a timescale from days to months. At any given time, their level (e.g. protein concentration, cell count, etc) is in equilibrium on the turnover timescale - i.e. the rate of creation approximately equals the rate of removal. For any X with turnover much faster than aging (i.e. decades), if we see the level of X increase/decrease on the timescale of a human lifetime, then that is not due to permanent “accumulation of X” or “depletion of X”; it is due to increase/decrease in the rate of creation/removal of X. For instance: DNA damage is typically repaired on a timescale of hours or faster, depending on the type. If DNA damage levels increase with age, that is due to an increase in rate of damage or decrease in rate of repair, not permanent accumulation. Typical senescent cells turn over on a timescale of days to weeks. If the number of senescent cells increases with age, that is due to an increase in rate of senescent cell production or decrease in rate of removal, not permanent accumulation. Elastin is believed to not turn over at all in humans. So if we see elastin deposits increasing with age (e.g. in wrinkles), then that could be permanent accumulation. Furthermore: suppose we have a positive feedback cycle. Increasing A decreases the rate of production of B, so B decreases. But decreasing B decreases the rate of removal of A, so A increases. If both A and B individually turn over on a timescale of hours or faster then this feedback loop as a whole will also typically operate on a timescale of hours or faster - i.e. count/concentration of A will explode upward on roughly that timescale. More generally, a feedback loop will usually operate on the timescale of its slowest component, exactly like the rate-limiting step of a chemical reaction. Main upshot of all this: since aging involves changes on a timescale of decades, there must be some component which is out-of-equilibrium on a timescale of decades or longer (i.e. does not turn ove...
Does anyone else want the “aging process” to slow down? Me too! As much as I love the wisdom that comes with age, I don't love the fact that my body doesn't always feel like a young spring chicken anymore. Today's episode is all about slowing down the aging process with my good friend and entrusted colleague, Pete McCall. Pete is an author, coach, podcaster, and he just released his new book called Ageless Intensity...Slowing the Aging Process. He is one of the top fitness experts in media publications and an avid researcher. This episode will deliver some great tips and information on how you can feel vibrant, healthy, and well as you age gracefully. In this episode, “Slowing the Aging Process” Pete delivers great tips, hacks, and exercises to live your best life and defy age. Specifically, this is what we cover in today's episode: - Hacks to defy the aging process - Elastin, collagen, and fascia...research on slowing the aging process - Steady state workouts and how to effectively use them to help burn fat - 4 principles on ageless intensity - Top strength exercises for people who are “aging” - Final 5 tips to age gracefully Please share this episode with your family, friends, and colleagues, and please share on your social media. Tag us at... IG/Twitter: @ToddDurkin, @AllAboutFitnesspodcast Twitter: @PeteMc_fitness FB: @ToddDurkinFQ10 #AgelessIntensity --- 8:22 - Aging...what is it and why does it happen? Exercise creates new cells and helps slow down the aging process along with caloric intake. 10:20 - What are some of the hacks to defy gravity? Consistent exercise and HIT (High Intensity) training become a mechanism to slow the aging process. 14:16 - What has been your discovery in the research with Elastin, Collagen, and Fascia with slowing the aging process? Mixing it up the routine and adding in flexibility or bodyweight after a heavy training day. We need more yoga! 20:37 - How often do you recommend steady-state workouts? Sleep plays a big role. 27:17 - What technologies are you finding in your research that are things that combat aging or improve performance? Power training. Strength training. Kettlebells. Blood Flow restriction BFR training 33:72 - Ageless Intensity...give us a few key principles or thoughts. Metabolic fatigue. Mobility. Foundation movement patterns. Healthy Fats - HDL 40:57 - Top strength exercises. Hip thrust. Kettle Bell swings. Barbell RDL. 47:33 - One of the best things about COVID. Getting back outside into nature and going for good hikes 48:41 - Age gracefully, 5 tips to slow down the aging process. #1. Exercise slows the aging process #2. Hydration #3. Sleep - Quality vs Quantity #4. Get good fats and lean proteins #5. Recovery 59:02 - Wrap up….Get Pete's book! Ageless Intensity: Effective Workouts to Slow the Aging Process https://www.amazon.com/Ageless-Intensity-Effective-Workouts-Process/dp/1718200757/ref=sr_1_2?dchild=1&keywords=ageless+intensity&qid=1616015679&sr=8-2 --- About Pete McCall: Pete McCall is a personal trainer, author of Ageless Intensity: Effective Workouts to Slow the Aging Process and Smarter Workouts: The Science of Exercise Made Simple, international presenter and host of the All About Fitness podcast. Pete delivers education and content solutions for a variety of health and fitness organizations including the American Council on Exercise (ACE), the National Academy of Sports Medicine (NASM) and Core Health & Fitness. Frequently quoted as a fitness expert in media publications, Pete is a sought-after media resource for accurate, in-depth insights on how to get results from exercise. Based in Carlsbad, CA, Pete holds a master's degree in exercise science and health promotion, is a Certified Personal Trainer with ACE and NASM and a Certified Strength and Conditioning Specialist (CSCS) through the National Strength and Conditioning Association. In addition to his books, Pete has authored numerous articles for fitness trade publications, exercise-science blogs and is one of a few individuals who has written textbook chapters for ACE and NASM, the two largest fitness certification organizations. Currently, Pete is the Senior Master Trainer for StairMaster and Nautilus for Core Health and Fitness the parent company of Nautilus and StairMaster, a blogger and writer for ACE (the largest accredited non-profit personal trainer certification organization in the country where he previously worked as an exercise physiologist) and both a content creator and an online instructor for the NASM (the largest for-profit personal trainer certification organization). www.petemccallfitness.com Author: Smarter Workouts - The Science of Exercise Made Simple https://us.humankinetics.com/products/smarter-workouts Author: Ageless Intensity: Effective Workouts to Slow the Aging Process https://www.amazon.com/Ageless-Intensity-Effective-Workouts-Process/dp/1718200757/ref=sr_1_2?dchild=1&keywords=ageless+intensity&qid=1616015679&sr=8-2 Host of the All About Fitness podcast https://podcasts.apple.com/us/podcast/all-about-fitness/id1115101341?mt=2 --- November is IMPACT Month - We will have an array of events throughout the month to raise funds for the Durkin IMPACT Foundation and to CREATE IMPACT! #1. Todd Durkin's IMPACT SUMMIT (Nov 7-12th) Revitalizing the Fitness Industry in these Crazy Times…& Forging What's Next for our Industry!!! 5-Days, 10 Presentations… WHO: All Trainers, coaches, and fit-pros Sign-Up TODAY...It's completely FREE!!! Check out www.todddurkin.com for more details. #2. A Day of IMPACT at Fitness Quest 10, Saturday, November 20th! 9 am PST--TD led workout 11 am PST TD IMPACT AMPLIFIED Talk Be there... You can also give back and donate online - 100% proceeds go to the foundation to support college-bound athletes and families in need. Additionally, your donation is completely tax-deductible. https://todddurkin.com/impact-foundation/ --- Today's Podcast Episode is sponsored by CarnoSyn beta-alanine CarnoSyn® bet-alanine is an ingredient within the top pre & post-workout supplements and I use it every day. A minimum dose of 3.2g per day and up to 6.4g for faster results. Only CarnoSyn® beta-alanine is backed by over 55 scientific studies and contains zero banned substances. To see the full list of CarnoSyn® Verified brands and to purchase, visit https://www.carnosyn.com/td/ --- Are you a Trainer, Coach, or Fitness Business Owner seeking to make even more IMPACT in your business & life? You are only as good as the people you surround yourself with. Level up today with my “Best in Class” MASTERMIND program for fitness professionals. I invite you to connect, share, and grow with the top coaches, trainers, and entrepreneurs in the fitness industry. My MASTERMIND is for passionate and purpose-driven fitness professionals who want to create success & significance in their personal and professional lives. If that sounds like you, visit: ToddDurkinMastermind.com to enroll or apply today. If you do so within the next 24 hours, you will receive a FREE video of one of my recent “ALL MASTERMIND” coaching calls. There are so many lost souls right now that need “our” LIGHT. Let's make a difference together, one life at a time! --- Please keep your questions coming so I can highlight you on the podcast!! If you have a burning question and want to be featured on the IMPACT show, go to www.todddurkin.com/podcast, fill out the form, and submit your questions! --- Follow Todd… → Instagram & Twitter: @ToddDurkin → Youtube: https://www.youtube.com/user/ToddDurkinFQ10 → FB: @ToddDurkinFQ10 Don't forget that if you want more keys to unlock your potential and propel your success, you can order my book GET YOUR MIND RIGHT at www.todddurkin.com/getyourmindright or anywhere books are sold. Get Your Mind Right now available on AUDIO: https://christianaudio.com/get-your-mind-right-todd-durkin-audiobook-download Want more Motivation and Inspiration?? Sign up for my newsletter The TD Times that comes out on the 10th of every month full of great content www.todddurkin.com --- ABOUT: Todd Durkin is one of the leading coaches, trainers, and motivators in the world. It's no secret why some of the world's top athletes have trained with him for nearly two decades. He's a best-selling author, a motivational speaker, and owns the legendary Fitness Quest 10 in San Diego, CA, where he leads an amazing team of 42 teammates. Todd is a coach on the Netflix show “STRONG” that is must-watch TV. He is a previous Jack LaLanne Award winner, a 2-time Trainer of the Year, and he runs his Todd Durkin Mastermind group of top trainers and fitness pros around the globe, coaching them with business, leadership, marketing, training, and personal growth mentorship. Todd and his wife Melanie head up the Durkin IMPACT Foundation (501-c-3) that has raised over $250,000 since it started in 2013. 100% of all proceeds go back to kids and families in need. To learn more about Todd, visit www.ToddDurkin.com and www.FitnessQuest10.com. Join his fire-breathing dragons' community and receive regular motivational and inspirational emails. Visit www.ToddDurkin.com and opt-in to receive his value-rich content. Connect with Todd online in the following places: You can listen to Todd's podcast, The IMPACT Show, by going to www.todddurkin.com/podcast.
Faszien sind feine, dünne Bindegewebsfasern, die den gesamten Körper (Knochen, Gelenke, Organe, etc). wie eine Schutzhülle oder wie ein großes Spinnennetz umgibt oder stützt und zusammen hält. Hätten wir keine Faszien, würde der gesamte Körper zusammenfallen. Gesunde Faszien sind hochelastisch und können sich gut auseinander und zusammenziehen. Sie sind sehr dehnfähig. Sie behstehen u.a. aus Kollagen, Elastin, Wasser und diversen Klebstoffen. Diese Mischung sorgt dafür, dass wir uns gut bewegen können. Faszien speichern knapp ein Viertel des Körperwassers und versorgt damit unsere Zellen und Oragane. Das Fasziengewebe enthält auch Abwehr und Lymphzellen, somit sogar ein Teil des Immunsystems. Um die Faszien wieder zu lösen, wird oftmals eine Bewegungstherapie empfohlen. Wie zum BEsipiel Yoga, Pialtes, Massagen oder Übungen mit Faszienrollen. Aber auch mit einer gesunden Ernährung, kannst du dem Verkleben von Faszien vorbeugen. Kerstin spricht darüber, wie du durch deine Ernährung die Faszien elastisch und geschmeidig erhalten kannst.
Freie Radikale haben Auswirkungen auf unsere Haut und unsere Gesundheit. Sie sind die Hauptursache von Zellschäden und Falten, denn sie greifen die Hautzellen, die Faserproteine, Kollagen und Elastin an. Dadurch verliert die Haut an Stabilität und Elastizität. Die Haut kann keine Feuchtigkeit mehr speichern, trocknet aus und wird faltig. Wir können unsere Haut und unseren Organismus aber aktiv schützen! Neben den geeigneten Pflegeprodukten gehört eine gesunde und ausgewogene Ernährung dazu – für unsere innere Beauty! Und warum das so ist, erklärt uns heute Felicitas Riederle von Epi-Food. 1. Was sind Freie Radikale? 2. Welche Folgen haben Freie Radikale? 3. Haben Freie Radikale auch eine gute Seite? 4. Was machen Freie Radikale mit unserer Haut? 5. Wie kann ich meinen Körper vor Freien Radikalen schützen? 6. Was sind Antioxidantien? 7. Mit welchen Lebensmitteln kann ich Antioxidantien durch meine Ernährung aufnehmen? 8. Kann ich Antioxidantien durch Nahrungsergänzungsmittel aufnehmen? 9. Hast du ein besonderes Gericht, das du mit uns teilen möchtest? Wir wünschen dir super viel Spaß beim Zuhören und hoffen, dass du ein paar Tipps für dich mitnehmen & umsetzen kannst!
Hear how the Maldives will create a "floating city" in hopes of combating rising seas that could wipe the archipelago out, how Russia and the US race to get dramatic in space, the latest on the swarms of stinky and tasty (oh, really?!) cicadas in the eastern part of America and one Frenchman's secret, snotty ingredient for soap!
Mineralet kisel spiller en helt central rolle for vores bindevæv og dannelse af kollagen. Uden kisel ville vi mangle kollagen og elastin, men det ville ikke kun gå udover huden, også hår, negle, knogler, tarm og blodkar ville mangle denne byggesten. Rynkerne ville være vores mindste problem, men vores forfængelighed og stræben efter en hud uden rynker, kan vise sig at være gavnligt for os.
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Er ist mittlerweile gar nicht mehr wegzudenken aus unseren Supermärkten, dem kleinen Teegschäft in der Innenstadt und aus der Fitness- und Ernährungswelt, der Grüne Tee.Was macht ihn so gut für uns? Welche Vorteile bringt sein Verzehr mit sich? Und wie konsumiere ich ihn richtig und schöpfe seine komplette Vielfalt an Vorteilen für mich aus?Genau darum geht es in dieser Episode, an deren Ende du mehr über seine Wirkung und bewussten Verzehr weißt und vorallem ein Stück Genuss dieses tollen Getränks für dich mitnehmen kannst!Wenn du Fragen und Anregungen hast schreib mir gerne! Du findest mich wie immer bei Instagram unter @ninavoelpel :)
Increase Collagen & Elastin Naturally With This Face Yoga Massage Hi Friends, PLEASE NOTE: This is a live tutorial if you find it challenging to follow, please visit my YouTube Channel to follow the Tutorial Video. https://youtu.be/kwZWgrFMFew Welcome to this video, I learned this beautiful massage in my training and have found it so useful for my skin, including helping with the increase of collagen and elastin. This Face Yoga massage allows you to support your skin naturally. I hope you enjoy this beautiful face yoga massage that will help to increase your collagen and elastin naturally. Please do share if you like and don't forget to give me a thumbs up for more content like this video. Thank you for your continuous support and love; it means so much. x Connect with me on Instagram: https://www.instagram.com/lotusfloweryoga/ FREE 31 Days of Yoga Course - https://www.lotusfloweryoga.co.uk/31-days-of-yoga Short Guided Meditation To Start Your Day - https://youtu.be/3MtpxuLMcps Beginners Yoga At Home - https://youtu.be/mMIrNeEbhzM How To Do Pigeon Pose - https://youtu.be/Ls84pAf2MHw How To Do Cobra Pose - https://youtu.be/GpRa8-DjD_4 How To Do Downward Facing Dog Pose - https://youtu.be/qgsewQNvC_g How To Do Upward Facing Dog Pose - https://youtu.be/silZJTDWQfc Join my Full-length private group LIVE YOGA Class Streams: Wednesday: 7:00pm-8:00 pm (BST) Friday: 7:00pm-8:00 pm (BST) Sunday: 11:00am-12:00 pm (BST) You can book your place or join our memberships at: https://www.lotusfloweryoga.co.uk MY YOGA FAVOURITES: Meditation cushion - https://amzn.to/2QEQgvR Writing Journal - https://amzn.to/2YREqTB My Leggings In The Video - https://tidd.ly/2PZ6H5H Yoga Book Recommendation - https://amzn.to/2Z2fRTn Toe Sox - https://amzn.to/2BFvg3J Yoga Mat - https://amzn.to/37Wgl1i Yoga Blocks - https://amzn.to/31d7vL6 Yoga Strap - https://amzn.to/3hVOva7 Your Beginners Yoga Guide: - https://amzn.to/2ROKUzl My poetry book : - Grow From The Inside' - https://amzn.to/3a3HJKm Weighted Blankets - https://amzn.to/3hMC4wJ I recommend that you seek medical advice before attempting any of my Yoga sessions Together online live sessions because some sessions may not be suitable for your body. It’s, therefore, important not to attempt any form of yoga without first consulting your doctor. You take full responsibility for yourself and anything you may do within the session or later during practice. You must be mindful and careful about your body so that you know when a position or movement may be unsuitable for you. I recommend that you do some research before attempting any of the postures. Please take your doctor’s advice to confirm that you are healthy and well enough to do the yoga postures and movements demonstrated in this video before attempting anything shown in this video. The same goes for all other content provided by me, including my pre-recorded yoga videos and my live classes. By relying on this video or any content provided by Katya or Lotus Flower Yoga, you agree that you take full responsibility for your body and any consequences including injury that you may sustain as a result. This session should only be attempted after your doctor has assessed you. Not all exercises are suitable for everyone. Your doctor will advise you about which exercise you can or cannot do. I take no responsibility for your practice and any consequences. I hope you found this video helpful. Please hit “Like” if you liked the video and want more such videos. Note: This description may contain affiliate links to products that we use personally. If you click on these links, this channel may earn a small affiliate commission at no extra cost to you. Thank you! Your support is highly appreciated.
Die Faszien haben in den letzten Jahren erheblich an Beachtung gewonnen. In dieser Episode möchte ich dir unser größtes Sinnesorgan vorstellen und dir seine Wichtigkeit für unsere Gesundheit und Fitness näher bringen.Dabei gehe ich auf die Faszien an sich ein, auf für uns wichtige Stoffe die in ihnen produziert werden und das Training der Faszien.Wenn du Fragen und Anregungen hast oder gerne Übungen für das Faszientraining hättest schreib mir gerne! Du findest mich wie immer bei Instagram unter @ninavoelpel :)
Es gab viele die ein zweites Video wollten zum Thema Faszien. Und zwar auf die Frage welche Methoden es noch gibt um die Faszienverklebungen zu lösen und den Heilungsprozess zu unterstützen. Wenn Du das erste Video noch nicht gesehen hast dann klicke hier: https://www.youtube.com/watch?v=Aus58x9Mf_U&t Stell Dir vor Du gehst am Strand spazieren in Mallorca. Es ist eine Ruhe und Stille. Morgens früh vor Sonnenaufgang. Du möchtest den Strand gerne genießen. Am Wasser entlang gehen. Das Wasser spüren. Du schaust rechts und links Aber wo Du auch hinsiehst. Überall Plastik. Flaschen liegen auf dem Sand und werden zum Teil vom Wasser angespült. Der Strand gleicht eher einer Müllablage als einem Strand in dem man sich wohlfühlt. So sehen bei vielen die Faszien aus. Zugemüllt mit Stoffen die da nicht hingehören. Verklebungen und Knoten stören den normalen und gesunden Ablauf der Faszien. Was kann man denn noch machen um den Strand von Plastik zu befreien also die Faszienverklebungen zu lösen. Erstens: Trampolin -Schwingen. Wenn Du ein kleines Trampolin zuhause hast. Top. Was passiert beim auf und ab schwingen. Deine Faszien werden trainirt. Auch Deine Knorpel und Bandscheiben haben was davon. Sie werden wie ein frisches Quellwasser vitalisiert und mit Flüssigkeit versorgt. Deine Pumpe Dein Herz wird angeregt und die Körperpolizei Dein Immunsystem gestärkt. Zweitens: Um den Strand sauber zu machen und ein schöne Umgebung zu schaffen muss aufgeräumt werden. Dabei hilft Dir Entsäuern. Damit schaffst Du ein optimales Milieu für die Faszien. Sie fühlen sich wieder wohl in Deiner Haut. Denn sie lieben es wenn Du basisch isst. Viel Obst und Gemüse. Frische Sachen. Was Dich enorm unterstützt sind Basenbäder. Stell Dir vor Du bist voller Matsch. Dieser ist teilweise schon hart geworten und überall sind krustige Stellen auf Deinem Körper. Du möchtest ihn loswerden um wieder frisch und sauber auszusehen. Du stellst Dich in die Dusche. Drehst den Hahn auf und lässt das warme Wasser an Dir herunterlaufen. So nach und nach wäscht sich der Dreck runter. Du siehst wie sich das graue Wasser an Deinen Beinen nach unten schlengelt. Und das schaffst Du für Deinen Körper mit einem Basenbad. Ein Basenbad beschleunigt die Entsäuerung. Der Dreck sprich die Säuren werden schneller ausgeleitet und aus deiner Haut geleitet. Deshalb würde ich Dir Basenbäder empfehlen oder Fußbäder. Diese beschleunigen die Entsäuerung und helfen Dir unterstützend. Nicht nur Dein Fasziengewebe profitiert davon sondern Dein kompletter Körper. Nicht nur Dein Fasziengewebe kann wieder aufatmen auch Dein Organismus freut sich. Und Drittens. Stell Dir vor DU hast zwei Hunde. Den einen fütterst Du mit frischen gesunden Sachen und den anderen mit ungesunden, Sachen wie Milchprodukte, Süßigkeiten, Alkohol. Dem einen Hund wird es gut gehen. Er wird sich wohl fühlen, laufen und springen. Der andere Hund wird krank in der Ecke liegen, traurig und es wird ihm schlecht gehen. Du entscheidest wie Du deine Faszien ernährst und wie es ihnen geht. Man kann das Fsaziengewebe zusätzlich stärken indem man organisches Silizium und OPC einnimmt. Dadurch wird die Bildung von Kollagen und Elastin beschleunigt und das Fasziengewebe schneller regeneriert. Das organische Silizium sorgt dafür das die neu aufgebauten Faszien über eine optimale Stabilität und Elastizität verfügen. Und OPC schützt als starkes Antioxidans die Bindegewebszellen vor den zerstörerischen Auswirkungen freier Radikale. Ich verlinke Dir die Produkte mal hier unten Teile das Video gerne. Schreibt mal unten in die Kommentare was ihr noch so sehen wollt. Abonniere den Kanal. Ist völlig kostenlos. Und wir sehen uns im nächsten Video wieder . Alles gute Ciau. Das organische Silizium sorgt dafür das die neu aufgebauten Faszien über eine optimale Stabilität und Elastizität verfügen. https://amzn.to/2Kokb8A Und OPC schützt als starkes Antioxidans die Bindegewebszellen vor den zerstörerischen Auswirkungen freier Radikale http://opc.gesundheitnextlevel.de
Nose to tail beef is an important topic for those supporting local, sustainable, regenerative agriculture. I get lots of questions on it. Buying a large quantity of beef can be a daunting prospect. Sure, you know it’s going to help your local farmer. And you know your local farmer is working hard for you, the animals and the environment. But what do you do with all that meat? What are the different cuts and what makes them different? How does a side of beef get broken down? What should you expect? Nose to tail beef is what this episode is all about. Let me take a minute and say welcome to new listeners and welcome back to the veteran homestead-loving regulars who stop by the FarmCast for every episode. I appreciate you all so much. I’m so excited to share with you what’s going on at the farm this week. Today’s Show Homestead Life Updates Nose to Tail Beef Moroccan Seasoned Meatballs Homestead Life Updates Creamery You will not believe how quickly that roof is going up. After months and months and months of concrete blocks, in just a few weeks, Scott has those blocks nearly covered with a roof. He tells me once the decking is complete—within the week, he will be starting on the other roof over the barn and milking parlor. That needs to be completed to the same point before putting on the metal roofing. I love going out there and strolling around in the rooms, imagining when it will be complete. Animals Winter is coming upon us and it is cold today and will be even colder in the coming days. The animals are all healthy and ready for it. Thick winter coats cover all of them. Thunder had a cut on his cheek that he got from who knows where. It is healing nicely, though it looked quite scary when I first saw it. Blood was running down the side of his head and there was this huge puckered gash in his jaw. But again, he is healing just fine. The girls are grazing calmly each day and growing their calves. The first expected birthing of a calf will be Claire on the 31st of March and Buttercup right behind her about three days later. The donkeys, sheep and goats are also grazing along. I was outside yesterday taking a tour of the creamery and saw that one of the goat does was in the pasture adjacent to everyone else. She will find her way back to the rest of the herd whenever she feels the urge. Goats are just gonna be goats. Still no quail eggs. They don’t eat much so I guess it’s okay. I can’t wait until spring and I start hatching out eggs again. The quail are just fun. The boys are all still peacefully grazing out front. There are five of them that will eventually make their way to freezer camp. And that brings me to today’s topic. Nose to Tail Beef Nose to tail beef is an important topic to understand when purchasing from your local farmer. Often beef is offered to you in quantities such as quarters and halves. Perhaps you will even purchase a whole beef and share the costs with family and friends. I’ll get to the various cuts often offered in one of these large purchases, including the organ and variety meats. I want to start with a brief history of beef in North America, some basic terminology, muscle composition, the structure of meat, aging, and inspection and grading. I’ll end with the various cuts available in beef and which part of the animal from which it is cut. This may be a long podcast. And I think the information will be invaluable to you as you develop a relationship with your local farmer. History of Beef in North America People have been raising domesticated cattle for some 3,000 years. Christopher Columbus introduced domesticated cattle to the Americas in 1493, and soon after, cattle arrived in present-day Florida and Texas with the Spanish. Cattle have always had many uses: they carry heavy loads and pull carts and plows; supply milk, cheese, and butter; and provide a source for clothing, shelter, and food. Today, Americans prefer beef to all other meats. As I noted, domesticated cattle first arrived in the Americas in 1493. By 1500 European cookbooks began to specify cuts of beef and other meats. During the period of the mid-1800s through 1900 cattle ranching in the United States reached its peak. In 1906 the meat inspection act was passed by Congress. Finally, beef surpassed pork as the most popular meat in 1950. Terminology Cattle is a general term for domesticated bovine animals raised on a farm or ranch for their meat, milk, or hides or for use as draft animals. Further delineation of cattle is characterized by sex and age. Calves are young cattle of either sex. A male calf is known as a bull calf, and a female Is called a heifer calf. Bulls are mature, un-castrated male cattle used for breeding. Steers are male cattle that have been castrated before reaching sexual maturity, making them more docile and easier to maintain on a ranch or in a feedlot. Most beef that Americans eat comes from steers. Staggs are male cattle that have undergone castration after they have matured. Heifer calves grow into heifers and eventually become cows. Cows are mature female cattle, and are usually used as a source of milk. They have to have given birth at least once to earn the title of cow. Nutritional Make Up Beef, like other meats, is animal muscle containing various nutrients that form part of a healthful diet. Muscle Composition The three main components of muscle are water, protein, and fat. These nutrients appear in the following proportions in most meats: 75% water 20% protein 5% fat Muscle also contains vitamins, minerals, and very small, trace amounts of carbohydrates. Although most meats are about three-quarters water, the actual amount of water in meats varies depending on shrinkage. Shrinkage, or moisture loss, is the result of oxidation, which occurs during storage or aging or as a result of high temperatures and long cooking times. Oxidation causes meat to lose both water and weight. Protein is an essential nutrient that promotes growth, builds tissue, regulates body functions, and serves as an alternative to fats and carbohydrates as a source of energy. Most solid matter in meat is protein. When heat is applied to meat, the protein coagulates, or becomes firm. The degree of coagulation is one gauge for doneness. High heat can cause protein to lose moisture and become too firm, making the meat tough. Fat surrounds the muscle tissue as a fat and lies within it (marbling). The fat may be left on a piece of meat during cooking to keep the meat moist, but barding or larding are acceptable alternative methods for retaining juice if there is no fat. Marbling also contributes to the juiciness of meat and makes it more tender and flavorful. Regarding vitamins and minerals, meat is an important source of vitamins A and K as well as several B vitamins, including thiamine (B1), riboflavin (B2), niacin (B3), B6, and B12. Meat also adds minerals such as iron and phosphorus to the diet. Although carbohydrates are present only in very small amounts, they contribute to the appearance and flavor of meat that is prepared with a dry technique such as roasting, sautéing, or broiling. Structure of Meat Meat products consist of bones, muscle fibers, and connective tissue. Bones: bone color is an indication of an animals age. The redder the bone, the younger the animal. Older animals have white bones. Becoming familiar with the bone structure of an animal helps when learning the different cuts of meat and how to debone them. Muscle fibers: muscle fibers, or cells bundled together, make up the meat. The thickness of the fibers determines the texture or grain of the meat. Thick, tough fibers bound in large bundles make up coarsely textured meats, such as bottom round or brisket. Thinner, tender fibers in small bundles form finely grained meat, such as tenderloin. Connective tissue: connective tissue is a web of proteins that perform several functions. It covers individual muscle fibers, bundles them together, and attaches them to bones. Connective tissue helps determine the texture of meat and is tough in general. Some meats are higher in connective tissue than others. Frequently used muscles such as those in the leg or shoulder have more connective tissue and thus are tougher than those in the back (or loin). Meat from older animals is also tougher because as an animal ages, the connective tissue becomes more resistant to breaking down. Elastin and collagen—the two kinds of connective tissue—differ in their ability to break down during the cooking process. Elastin is a hard, yellow connective tissue prevalent in older animals because it will not break down during cooking, elastin must be cut away from the meat or physically tenderized to reduce its effects. By contrast, collagen, the soft, white connective tissue, really breaks down into water and gelatin with slow, moist cooking. Collagen also responds well to tenderizing. Aging Aging is the process by which naturally occurring enzymes (lactic acid) tenderize meat. After slaughter, chemical changes in the flesh of an animal cause rigor mortis, or a stiffening of the muscles. As rigor mortis disappears, the meat softens, or ripens, as a result of enzymatic action. This process takes up to several days for beef and must occur in a controlled, refrigerated environment so that the meat does not spoil. The result is flavorful, tender meat. There are three methods of aging meat under refrigeration. Today I will discuss dry aging as this is the method used by small, independent meatpackers. Dry aging involves hanging large, unpackaged cuts of meat in a controlled environment for two to six weeks. Temperature, humidity, and air flow must be carefully monitored to prevent spoilage. Two weeks is most common. Small, local meat processing facilities are limited by space and energy cost controls. Although costly, dry aging produces extremely flavorful meat with a highly desirable texture. However, shrinkage is a major drawback of this method, with some cuts of meat losing as much as 20% of their weight through loss of moisture. Meat aged by this method also can develop mold, which requires trimming—a further reduction in weight. Inspection and Grading Inspection and grading systems help producers, distributors, and consumers like you evaluate meat. Inspection—The Meat Inspection Act, passed in 1906, mandates the examination of all meat transported across state lines. This federal law guarantees that meat is wholesome and fit for consumption and that the animal for which it originated was not diseased; however, inspection is not a mark of quality. USDA/FSIS—The Food Safety and Inspection Service (FSIS), a public health agency within the United States department of agriculture (USDA), is responsible for conducting inspections. The FSIS checks meat to make sure that it is clean, safe, and properly packaged and labeled. Meat that satisfies inspection standards carries a USDA inspection stamp. Grading—unlike inspection, grading is completely voluntary. Grading measures meat quality, allowing a comparison of meat quality grading indicates tenderness, juiciness, and flavor of the meat. The USDA has eight quality grades that apply to beef. Prime is the highest quality, most expensive, with abundant marbling because of the young age of animals and feed practices. It is extremely juicy and flavorful. Choice is high-quality, very juicy and tender, in abundant supply, widely available to the public. The select grade is acceptable quality. It is a good buy, generally lean with little marbling, and less juicy and tender. Standard grade is lower quality. It is economical and lacking in marbling. Commercial grade is low quality. It is produced from older animals is economical and lacking tenderness. Utility, cutter, and canner are the lowest quality. This grade of meat is used primarily by canners and processors. Kobe Beef Up to now I have been speaking only of US beef grades. Now I will touch upon one other. Kobe Beef. Cattle raised in Kobe, Japan, are the source of a special grade of beef that is rich in flavor, has abundant marbling, and is extraordinarily tender. Kobe beef comes from the Wagyu breed of cattle and meets rigorous production standards. Wagyu cattle are famous for the extensive marbling of their meat, but this quality characteristic is not entirely the result of genetics. The daily routine and special diet of cattle raised for Kobe beef are quite unusual. The Wagyu cattle receive energizing massages with sake, the Japanese alcoholic rice beverage, and indulge in huge quantities of beer, making Kobe beef legendary and expensive. By USDA standards Kobe beef would receive the highest yield and quality grades. It’s marbling and rareness in the marketplace actually put it well above the prime grade. Once raised only in Kobe, Wagyu cattle now roam ranches in the United States and Australia, where land and feed are cheaper. Fabrication of the prized beef, however, takes place in Kobe, which earns it the name Kobe beef. Primal, Subprimal, and Fabricated Cuts Beef and other meats are available for purchase in various forms: carcasses; partial carcasses; and primal, subprimal, and fabricated cuts. The carcass is the whole animal after slaughter, without head, feet, hide, and entrails. It is typical to split a beef carcass into halves and then to cut each half into a front portion or forequarter and a rear portion or hind quarter. A side or a quarter of beef represents a partial carcass. There are two front quarters, right and left. The front quarter starts at the neck and ends where the ribs end, about halfway down the back of the carcass. The rear quarters pick up from there. Again, there are two, right side of spine and left side of spine. A primal cut is a large, primary piece of meat, sometimes called a wholesale cut. A subprimal cut is a basic cut made from a primal cut. A fabricated cut is the smaller portion taken from a subprimal cut, such as a roast, steak, and ground meat. Beef Carcass Forequarter Now think of the front quarter divided into four smaller pieces. From shoulder to mid back, there are four primal cuts that make up a forequarter of beef: Chuck (shoulder of the animal), primal rib (main rib section), brisket (breast and foreleg or shank), and short plate (directly below the ribs). Those four primal cuts are broken down into subprimals and finally a fabricated cut. Chuck The chuck comes from the animal’s shoulder. It includes part of the backbone and the first five rib bones as well as portions of arm bones and blade bones. The chuck makes up nearly 30% of the weight of the beef carcass. A fairly large portion of the chuck is connective tissue, which accounts for the toughness of this meat. However, chuck has a great deal of flavor when properly prepared. A moist technique or combination method such as stewing or braising is appropriate for this cut. The primal chuck yields various fabricated cuts: shoulder roast, chuck roast, chuck short ribs, cubed or tenderized steaks, stew meat, and ground chuck. Primal Rib This primal cut comprises about 10% of the carcass weight. It includes ribs six through 12 and some of the backbone. As it is not well exercised muscle, it is tender, owing its rich flavor to extensive marbling. Primal rib cuts benefit from dry cooking methods such as roasting, broiling, and grilling. Moist heat is the preferred method for short ribs. Fabricated cuts taken from the primal rib include rib roast, boneless ribeye, short ribs, and ribeye steaks. Rib roast, better known as prime rib, is an extremely popular meat dish. The word “prime,” however, does not represent a USDA grade; rather, it indicates that the rib roast makes up most of the primal cut. Brisket Located below the chuck, the brisket constitutes a single primal cut. This cut consists of the breast (brisket) of the animal, including the rib bones and Cartledge, and the breastbone. A combination technique such as braising is an excellent choice for beef brisket, which is very tough. Curing, another method of preparation for brisket, is the method used to produce corned beef. Fabricated cuts from this primal cut include boneless brisket and ground meat. Short Plate Short plate is the cut below the primal rib on a side of beef. It contains rib bones and Cartledge and the tip of the breastbone. Fabricated cuts from the short plate include ground beef, skirt steak, and short ribs. Moist cooking is appropriate for short ribs, which are quite meaty but also contain a large amount of connective tissue. Marination and grilling are excellent methods for skirt steak, which is sliced for fajitas. Foreshank The foreshank is considered a byproduct of the beef forequarter and may be attached to the chuck when purchased. The rich flavor of the four shank and its abundant collagen, which turns to gelatin with moist heat, make it a choice ingredient in stocks and soups. Fabricated cuts include stew meat and ground beef. Beef Hindquarter A beef hindquarter also yields four primal cuts: short loin, sirloin, round, and flank. The short loin, sirloin, and round are the rest of the spine divided roughly into thirds. The fourth portion, the flank is directly below the short loin and sirloin. The round primal cut is very large as it is essentially the hind leg. Short Loin The short loin is the first primal cut of the hindquarter, forming the front portion of the beef loin. It includes one rib and part of the backbone the yield of this primal cut is substantial and represents the most palatable and popular, as well as the most expensive, cuts of beef. Among these is the tenderloin, the most tender piece of beef. Fabricated cuts from the short loin include T-bone steaks, NY strip steaks, and tenderloin. These cuts are best cooked using dried methods. Broiling, roasting, and grilling. Sirloin Located next to the short loin, the sirloin contains a portion of both the backbone and the hip bone. The subprimal and fabricated cuts taken from the sirloin have good flavor and are quite tender, though not as tender as the short loin cuts. Fabricated cuts from the sirloin include top sirloin roasts and steaks and top and bottom sirloin butt roasts and steaks. The dry techniques of broiling, roasting, and grilling are best for these cuts. Round The round is the hind leg of the animal, including the round, shank, and tail bones. It is an extremely large cut, constituting approximately 24% of the carcass weight. Very flavorful and fairly tender, the round yields various subprimal and fabricated cuts, including top round, bottom round (eye of round and heel of round), knuckle, and shank. Dry cooking such as roasting is appropriate for top round, which is relatively tender. The top or bottom round benefits from combination cooking such as stewing or braising. Lots of ground beef from this area as well. Flank Beneath the loin and behind the short plate (forequarter) is the flank. The flank contains a good amount of fat and connective tissue, which makes it tough. Flank yields flank steak. Moist cooking techniques are best for flank cuts. One final note. When choosing to purchase a quarter, half, or whole beef, in addition to these cuts somewhere between 35% and 50% of the packaged fabricated cuts will be ground beef. Variety Meats Variety meats include internal organs, glands, and other meats that are removed during the processing of the carcass. Traditionally viewed as ethnic food items, variety meats have found their way onto American menus in limited quantities. High in protein, vitamins, and iron, variety meats are features of soups, stews, and other dishes. All the beef variety meats except kidney are muscle tissue. These meats are tough in general and require long, moist cooking to become tender. Kidneys are the only glance from beef served with much frequency. Heart Tough but lean, the heart lends itself to braising or stewing. Ground heart can be added to meatloaves or to casseroles calling for chopped meat. Be sure to remove veins and fibers before cooking. Liver Beef liver is dark in color and has a strong flavor. It should be broiled, braised, or panfried. It is often served with onions and is added to pies and puddings. Tongue The customary method for cooking tongue is simmering. After cooking, remove the skin and gristle. Cooked and chilled beef tongue is a favorite sliced meat for sandwiches. Smoking and curing are other methods of preparation before cooking. Oxtail Before cooking, oxtails need to be cut into sections at the joints. Oxtails are rich in gelatin and also contain tasty meat, both of which augment the texture and flavor of soups and stews. Kidney Beef kidney is somewhat tough and has a relatively strong flavor. Braising helps tenderize this variety meat, which is a key ingredient in steak and kidney pie. I’m currently working on a cookbook that will have at least one recipe for every cut of meat I’ve described in this podcast. One of the challenges when purchasing a quarter, half, or whole beef is what to do with all of those cuts of meat and variety meats. I hope to fill in that gap for you with my whole beef cookbook. You can be confident in being able to use all of the great grass-fed meat in which you invested. At the last farmers market, I brought Moroccan seasoned meatballs to give customers an opportunity to taste the quality of our lamb. Today’s recipe is in response to a direct request from several of my customers who read my newsletter and love the recipes. Moroccan Seasoned Meatballs Seasoned with a Moroccan-style blend of fresh mint, cinnamon, coriander and cumin and simmered in tomato sauce, these tender lamb meatballs make a flavorful change from their Italian-style cousins. Prep time: 20 minutes Cook time: 25 minutes Total time: 45 minutes What You Need Meatballs 1 lb ground lamb 1 egg, slightly beaten 1 clove garlic, very finely chopped 2 tablespoons bread crumbs 1 ½ tablespoons fresh mint leaves, finely chopped 1 tablespoon fresh parsley, finely chopped ½ teaspoon ground cinnamon ½ teaspoon ground coriander ½ teaspoon ground cumin 1 teaspoon salt ¼ teaspoon ground black pepper 2 tablespoons cooking oil Sauce 2 tablespoons cooking oil ½ cup onion, chopped 3 cloves garlic, very finely chopped 2 cups diced tomatoes, undrained ½ to 1 teaspoon cinnamon ½ to 1 teaspoon ground coriander Salt and pepper to taste What To Do Combine the lamb, egg, garlic, bread crumbs, mint, parsley, cinnamon, coriander, cumin, salt and pepper in a large bowl. Form the mixture into 16 to 18 meatballs about 1 ¼ inch in diameter. Heat the olive oil in a large, heavy skillet over medium-high heat. Add the meatballs and cook until lightly browned on all sides, about three minutes total. Transfer the meatballs to a plate, drain the excess fat from the pan and return it to the stove. To make the sauce, heat the olive oil over medium heat. Add the onion and sauté until soft and translucent, 3 to 4 minutes. Add the garlic and continue cooking until fragrant, one minute longer. Stir in the tomatoes. Add ½ teaspoon each of cinnamon and coriander and season to taste with salt and pepper. Cook for two minutes, then taste again and adjusted the spices as desired. Return the meatballs to the pan and turn several times to coat them with the sauce cover and simmer slowly until the meatballs are cooked through, 6 to 8 minutes. Transfer the meatballs and sauce to a serving dish, garnish with parsley and serve with steamed white rice. Enjoy!!! Final Thoughts That’s it for this podcast. The farmstead keeps on keeping on. The creamery gets closer and closer to completion with every passing day. The animals continue to thrive and enjoy their pasture-based existence. I hope you enjoyed the ins and outs of beef and you better understand the nose to tail beef option. It is the lifeblood of many local farmers. They invest a great deal of time and energy into a beef product you can trust. Look for my new Whole Beef Cookbook in the coming weeks. And do give the meatballs a try. I know, I know it’s lamb, not beef. But they are excellent just the same. If you enjoyed this podcast, please hop over to Apple Podcasts, SUBSCRIBE and give me a 5-star rating and review. Also, please share it with any friends or family who might be interested in this type of content. As always, I’m here to help you “taste the traditional touch.” Thank you so much for stopping by the homestead and until next time, may God fill your life with grace and peace. Recipe Link Moroccan Seasoned Meatballs To share your thoughts: Leave a comment on our Facebook Page Share this show on Twitter, Facebook and Instagram To help the show: PLEASE LEAVE A REVIEW for Peaceful Heart FarmCast on Apple Podcasts. Subscribe on iTunes, Stitcher Radio, Google Play Music, TuneIn or Spotify Donate on Patreon Website www.peacefulheartfarm.com Patreon www.patreon.com/peacefulheartfarm Facebook www.facebook.com/peacefulheartfarm Instagram www.instagram.com/peacefulheartfarm/
This month on Episode 6 of the Discover CircRes podcast, host Cindy St. Hilaire highlights five featured articles from the October 25 and November 8, 2019 issues of Circulation Research and talks with Coleen McNamara and Aditi Upadhye about their article, Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis. Article highlights: Omura, et al. ADAMTS8 in Pulmonary Hypertension. Rödel, et al. Blood Flow Suppresses CCM Phenotypes in Zebrafish Cai, et al. Proteomics Assessment of hPSC-CM Maturation Shin, et al. Leptin Causes Hypertension Via Carotid Body Trpm7 Lin , et al. Cellular Heterogeneity in Elastin Deposition Transcript Dr Cindy St. Hilaire: Hi. Welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire and I'm an assistant professor of medicine at the University of Pittsburgh. In this episode I'm going to share with you some highlights from recent articles that were published in the October 25th and our November 8th issues of Circulation Research. We're also going to have an in-depth conversation with doctors Coleen McNamara and Aditi Upadhye, who are the lead authors in one of the exciting discoveries from our October 25th issue. The first article I want to share with you is titled ADAMTS8 promotes the development of pulmonary arterial hypertension and right ventricular failure, a possible novel therapeutic target. The first author is Junichi Omura and the corresponding author is Hiroaki Shimokawa, and the work was conducted at Tohoku University, Sendai, Japan. Pulmonary hypertension is caused from the excessive proliferation of the vasculature in the lungs. It has contributions from smooth muscle cells, endothelial cells, inflammatory cells, and these cells proliferate and occlude the small vessels in the lungs. And this occlusion leads ultimately to failure of the right heart ventricle. Current therapies only treat the symptoms, not the underlying pathology. So there really is a big push right now to try to discover novel therapeutic targets. The authors of this study performed a gene expression screen, and in this screen, they compared pulmonary artery smooth muscle cells from pulmonary hypertension patients to those same cells from healthy controls. The research has found numerous differentially-expressed genes. However, they chose to focus on one called ADAMTS8. And they focused on this because the protein is expressed specifically in the lungs and heart tissues, and it was significantly upregulated in the patient's cells. So ADAMTS8 is a secreted zinc dependent protease, and this protease function makes it potentially a druggable target. So similar to human cells, ADAMTS8 was also found to be upregulated in the lungs of mice with pulmonary hypertension and a lack of vascular ADAMTS8 attenuated the disease symptoms. Conversely, overexpression of ADAMTS8 in pulmonary artery smooth muscle cells from both mice and humans prompted increased proliferation. They performed a high throughput screen to try and identify compounds that would suppress ADAMTS8 and pulmonary artery smooth muscle cell proliferation. And in this screen, they found mebendazole, which is a drug that is already in clinical use for parasitic worm infections. Thus, the study not only pins ADAMTS8 as a driver of pulmonary hypertension, but also suggests a potential existing drug might be useful for treating it. The next manuscript I want to share with you is titled Blood Flow Suppresses Vascular Anomalies In a Zebrafish Model of Cerebral Cavernous Malformations. The first author is Claudia Jasmin Rödel, and the corresponding author is Salim Abdelilah-Seyfried, and they are from the University of Potsdam in Potsdam, Germany. Vessel diameter and geometry as well as blood velocity and flow speed, all affect how the flow of blood impacts biomechanical forces that are received by the endothelial cells that line the lumen of vessels. Pathological changes in biomechanical signaling pathways or abnormal patterns of blood flow have been implicated in the etiology of various vascular diseases, and this manuscript is focusing on one: cerebral cavernous malformations, or CCMs. There are various genetic causes of CCMs, and this combined with several lines of evidence, point to a role for blood flow in CCM lesion development. Specifically, patients typically develop CCM lesions only in low perfused venous capillaries. Those are slow flow vessels. Rarely are high flow vessels affected. The authors want to answer the question, why do CCMs develop in low flow areas and more broadly, what is the role of hemodynamic forces in CCM pathology? To explore the role of blood flow and vascular remodeling, they use a zebrafish model. This is a great model to study this specific type of malformation, because the zebrafish itself is transparent and you can do an amazing way of imaging and I highly recommend that you go online and check out some of the videos that are supplemental figures for this paper. They're beautiful, they're neat, and you can really see the blood flow in these zebrafish models that they use. Okay, so which models did they use? They used ones that had normal levels of blood flow or normal speeds of blood flow, and then a zebrafish that is actually absent of any blood flow. Which is crazy that it can live for any amount of time. And so they use these zebrafish and looked at the lateral dorsal aorta, which is a high shear stress vascular bed. They found that blood flow induces a protective response in endothelial cells. This finding helps to explain why CCM patients never suffer from vascular anomalies within highly perfused blood vessels since these vessels are protected by the flow itself. The next paper I want to highlight is titled An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. The first author is Wenxuan Cai and the corresponding author is Ying Ge, and they are from the University of Wisconsin Madison in Madison, Wisconsin. Cardiomyocytes are the beating cells of the heart and they're very difficult to work with in culture as they don't proliferate very well. As such, scientists are moving to use human induced pluripotent STEM cells as means to create cardiomyocytes. So cardiomyocytes derived from human pluripotent stem cells are a valuable resource for drug discovery and screening and disease modeling. While useful, these pluripotent stem cell-derived cardiomyocytes remain immature compared to their natural adult counterparts, and this immaturity slightly reduces their utility. So there are now several methods that people use to promote maturation of cardiomyocytes, but currently there's no consensus on the best way to assess cardiomyocyte maturity, or rather, IPS cardiomyocyte maturity. In this manuscript, Cai and colleagues have established a straightforward yet comprehensive mass spectrometry approach to ensure cardiomyocyte maturity. This method combines analysis of a subset of intact proteins with an unbiased screen of digested peptide fragments. The team used the method to examine early and late stage maturation of cardiomyocytes derived from embryonic, as well as human induced pluripotent stem cell sources, validating their findings against cells from mouse hearts. For the intact protein analysis, sarcomeres were isolated from cell samples which enabled the identification of the major sarcomeric proteins, as well as any post-translational modifications on these proteins that can fine tune our assessment of maturity. The unbiased screen further identified both known and novel maturation markers. This study not only provides a handy tool for assessing IPS-derived cardiomyocyte maturity, but it also defines a set of maturity markers for cross reference in future studies. The next paper I want to discuss is titled Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7, Trpm7, Channel In the Carotid Body. The first author is Mi-Kyung Shin, and the corresponding author is Vsevolod Polotsky, and they are from the Johns Hopkins University in Baltimore, Maryland. Leptin is a hormone that is secreted from fatty tissue, and it's secreted in response to eating something fatty and delicious. Leptin signaling increases metabolism and blood pressure, and it also helps to reduce appetite. That is, if you don't eat the fatty food too fast. So, obese individuals can exhibit high levels of leptin, yet their metabolism and appetite may be unaltered, while hypertension may still develop. Leptin's effects on appetite metabolism are mediated via signaling in the brain, while its effects on blood pressure are thought to be mediated elsewhere. In this manuscript, the authors suspected that the carotid body has something to do with this. The carotid body is a cluster of cells in the neck that detect blood levels of oxygen and other substrates, and the carotid body cells can communicate the information to the brain via the carotid sinus nerve. The carotid body has abundant expression of leptin receptor, and moreover, leptin has been shown to increase carotid sinus nerve firing. So in this manuscript, the authors now show that infusions of leptin into mice increased hypertension in the animals only when the carotid sinus nerve was intact. They also showed that hypertension in these mice was dependent on the iron channel Trpm7, which is very abundant in the carotid body. Inhibition of Trpm7 prevented the leptin-induced hypertension. Together, these results begin to explain why obese individuals' leptin still induces hypertension when the hormone's other effects on appetite and metabolism are diminished. They suggest that inhibition of Trpm7 could perhaps be a way to treat the hypertension seen in obese individuals. The last paper I want to highlight before we move over to our interview is titled Heterogeneous Cellular Contributions to Elastic Laminae Formation and Arterial Wall Development. The first author is Chien-Jung Lin, and the corresponding author is Jessica Wagenseil from the Washington University in St. Louis. Elastin is the extracellular matrix protein that provides structure to both large and small arteries. Vascular smooth muscle cells are known to produce the layered elastic laminae found in elastic arteries. However, they synthesize very little elastin in more muscular arteries. Muscular arteries also have well-defined internal elastic laminae that separates the smooth muscle cells from the endothelial cells, but the source of the elastin in these muscular arteries is not well-defined. The goal of this study was to define the extent to which endothelial cells can contribute to elastin in the eternal elastic laminae of various arteries. To address this question, they created several new strains of mice in which elastin is deleted specifically in a smooth muscle or an endothelial cell. They found that smooth muscle cells and endothelial cells can both independently form an internal elastic lamina in elastic arteries. In muscular and resistance arteries, however, endothelial cells are the major source of elastin. Further, in the ascending aorta, it was noted that ill-formed internal elastic laminae was associated with neointimal formation, confirming that the internal elastic laminae is a critical physical barrier for smooth muscle cells and endothelial cells in large elastic arteries. This study provides new information about how smooth muscle cells and endothelial cells contribute to elastin production in the artery wall, and also how local elastic laminae defects may contribute to cardiovascular disease. I'm here with Dr Coleen McNamara and Aditi Upadhye, and we'll be discussing their paper titled Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. And this paper is was published in our October 25th edition of the journal. So thank you both so much for joining me today. Dr Coleen McNamara: Thank you for having us. Dr Aditi Upadhye: Thank you. Dr Cindy St. Hilaire: I'm really looking forward to learning more about this paper. First, I'm wondering if you could just please introduce yourselves and give us a little bit about your background. Dr Coleen McNamara: Well, I'm Coleen McNamara. I'm a physician scientist in the Cardiovascular Research Center at the University of Virginia in cardiovascular medicine. And my laboratory studies B cells and atherosclerosis predominantly. And that's the topic of Aditi's paper. Dr Aditi Upadhye: And I'm Aditi Upadhye. I'm a PhD student in Coleen's lab and my project in Coleen's lab has focused on the role of CXCR4 in B-1 cell IgM production in atherosclerosis. Dr Cindy St. Hilaire: If this is your project, you must be nearing the end of graduate school then. Dr Aditi Upadhye: Yes, very close. Dr Cindy St. Hilaire: Excellent. And congratulations on a beautiful paper. Dr Aditi Upadhye: Thank you so much. Dr Cindy St. Hilaire: So I was just reading the paper and I did see that you stated the objective of the paper, was that you wanted to characterize bone marrow IgM repertoire and determine whether CXCR4 regulated the B-1 cell production of this atheroprotective IgM. Could you maybe just give us a quick primer on what all those words mean? What is a B-1 cell, what is IgM, and what is this atheroprotectiveness, and why is this important to research? Dr Aditi Upadhye: Sure. So research over the past few decades has shown that the role of B cells in atherosclerosis is subset specific. So in mice there are two broad categories of B cells. B-1 and B-2. And B-2 cells are the ones you typically learn about in immunology classes. They're the ones that produce really high affinity class-switched antibodies in a T-cell dependent manner. And there is evidence that B-2 cells are atherogenic. So either through their ability to modulate T-cells through cytokine production, or through their production of IgG and IgE antibodies, they may have atherogenic capability. B-1 cells are very, very different. They produce what are called these natural IgM antibodies. So they're present even in germ-free mice that don't have any prior antigen exposure, exogenous antigen exposure. And the kind of paradigm in the field thus far had been that B-1 cells produce germline-encoded antibodies. So they don't acquire quite as much diversity as their B-2 cell counterparts do. And really importantly, it has been shown that B-1 cells are an atheroprotective cell subset, primarily through their ability to produce IgM. So our coauthor, Dr Joseph Witztum, previously demonstrated that B-1 cells produced IgM antibodies against oxidation specific epitopes that arise on oxidized LDL in atherosclerosis. But really the mechanisms that regulate IgM production and what these IgMs are targeted against is less known. And that's something that we were trying to get at with this paper. Dr Cindy St. Hilaire: One of the things you talked about in one of the earlier figures in your paper was that there's differences in the chemokine expression between these B cells that are in the spleen versus when they're in the bone marrow. And these differences are apparent at baseline, but also under hyperlipidemic conditions. Is there a cause or a consequence angle to asking this question about B-1 cells and atheroprotectiveness? Dr Aditi Upadhye: Yeah, I think so. One of the points of this paper is that B-1 cells are very heterogeneous and so they may be going to multiple locations, not just the bone marrow, which we focus on in our paper, but also the spleen, also the perivascular adipose tissue, are sites that we're also interested in looking at. So the fact that there is different chemokine ligand expression level on these different sites might guide them to these different places and might help with their function. Dr Cindy St. Hilaire: Yeah, and I guess that's a perfect segue for my next question. And it seems that the CXCR4 expression on the cells is really key to their proper migration and then the subsequent secretion of the IgM. Do we know what's happening to CXCR4 expression either as we age or as atherosclerosis progresses? Is there any evidence of environmental or behavioral or genetic angles that might predispose an individual to having more or less CXCR4 on their B cells? Dr Aditi Upadhye: That's a great question. So there are a lot of things that regulate chemokine receptor expression, including expression of the ligands too. I don't know that much about how CXCR4 expression changes with age or with atherosclerosis. At least in mice, it seems that CXCR4 doesn't change during hyperlipidemia. So for example, in C57 black 6 mice versus a ApoE knockout mice, either child fed or Western diet fed, CXCR4 doesn't seem to change on the one cell subsets. Dr Cindy St. Hilaire: Interesting. Maybe a future project then. Dr Aditi Upadhye: Yeah. Yeah. Dr Cindy St. Hilaire: So I found it really interesting, I think it was in figure five, I always like to try to pick out my favorite figures. My favorite figures of this paper are three, five, and seven. And so... Are those your favorite? But so I guess one of the things that I thought was interesting is that you made a mouse, a multiple knockout mouse that had ApoE knockout and it also was not able to make IgM antibodies. Is that correct? So when you took that mouse and then you looked at it, I think at 80 weeks of age, you could see differences in the atherosclerosis on these mice, but then you couldn't see it on kind of the standard model of what probably most atherosclerosis labs use. And that is a younger mouse that's put on a high fat diet for a shorter window of time. And so could you maybe talk about what that difference means, what your study shows, and then how do we move forward with studying the role of inflammation and atherosclerosis in younger versus older mice? Dr Aditi Upadhye: Yeah, that's a great question. And I think that every model has its caveats that, and that's something that we ran into when we were trying to show whether B-1 cell CXCR4 is important in atheroprotection. But I think what our findings suggest is that there is a very delicate balance between the amount of IgM that you have and the lipid burden that you have. And in any given model, these might be factors to consider when it comes to studying atherosclerosis. Just taking those factors into consideration when you're analyzing your atherosclerosis results. Dr Cindy St. Hilaire: Absolutely. Dr Coleen McNamara: One of the reasons we liked this 100-week-old, or the 80-week-old mouse is the one where if it doesn't have IgM, there's significantly more atherosclerosis even on a chow diet. And so that's a cholesterol of about 300 or 400, and then an 80 to a 100-week old mouse is about the equivalent of a 70-year-old person, which is sort of more akin to the human situation. And so in that setting, the IgMs matter, whereas it didn't look like the IgMs as Aditi said were really capable of blocking the oxidized lipids that were generated in younger mice that had cholesterols well over a thousand. So we felt like that that was really relevant, which is why we use that same model for when we did the single cell sorting and sequenced the antibody repertoire. Thinking that that would give us more insight into the role of age and modest hyperlipidemia, which is more the clinical scenario. Dr Cindy St. Hilaire: Do you think that has implications for how humans with familial hypercholesterolemia are treated versus someone with just a lower level but still elevated lipid profile? Dr Coleen McNamara: Yeah, I do, and I think that's really an important point, Cindy, because the vast majority of people that suffer from cardiovascular disease, have heart attacks, die of cardiovascular disease, are typically older people with modest cholesterol levels. Familial hypercholesterolemia, obviously in those patients, they get significant cardiovascular disease at young ages. But that's certainly in a relative sense, a much less common occurrence. So I think that the model and the mechanisms that we were looking at are more applicable than garden variety atherosclerosis. Dr Cindy St. Hilaire: Interesting. That's something I haven't really thought about. We always just kind of use these mice to model athero and try to do it in the quickest way possible to get the papers out. But it's really interesting. Dr Coleen McNamara: We use a lot of mouse models and we use young models with hypercholesterolemia in our laboratory as well. So I think that there's a real role for doing that. And a lot of people have really advanced the field with those types of models as well because they allow you to ask mechanistic questions. Dr Cindy St. Hilaire: One of the things you mentioned in the paper was the variability of the IgMs produced, that there's not just one IgM, there's different flavors, I guess is a way to put it. Can you maybe just talk about that a little bit, what that might mean? And then I have another follow-up question after that. Dr Aditi Upadhye: Sure. So B-1 cells, the B cell receptor, it's different on different B cells. And so that is made through a process called VDJ recombination. And the B cell receptor determines what your antibody is going to be specific for. There's a lot of different IgMs present within a given B cell repertoire because the differential combination of all these genes makes up the repertoire. Dr Cindy St. Hilaire: What is it about the IgM that makes it atheroprotective, what's it actually targeting? Dr Aditi Upadhye: That's a great question. So Dr Witztum and colleagues and others have shown that these IgMs target oxidation specific epitopes. And for example, one of them that we focus on in this paper is malondialdehyde-modified LDL. And so these IgMs can recognize MDA and either facilitate its clearance or prevent it from being bound to macrophages and prevent inflammatory processes within those macrophages downstream. Dr Cindy St. Hilaire: So essentially this IgM is kind of working to prevent foam cell formation? Dr Aditi Upadhye: Yes. Dr Cindy St. Hilaire: Excellent. Dr Coleen McNamara: So these are, these modified lipids are danger associated molecular patterns, as you've heard about before. So not only are these modified lipids taken up into the macrophage by scavenger receptors, which we know is an atherogenic, a process that leads to atherosclerosis, but they can also activate inflammatory pathways through toll-like receptors. Dr Cindy St. Hilaire: So in light of the variability, I guess what I'm wondering is, is there more variability in these IgMs based on atherosclerotic state or in humans, healthy or control, and then also how are these heterogeneous populations of cells, how does your finding coincide with the recent studies on clonal hematopoiesis? And I was wondering if you could talk a little bit about that. Actually, for people who don't know, the idea... I guess I should explain the idea of clonal hematopoiesis. So essentially there was a recent paper in Science by Ken Walsh, who's actually at UVA now, where they found that there's acquired mutations in hematopoietic stem cells, and as we age, those mutations can become enriched and therefore somewhat clonal, hence the term clonal hematopoiesis. So how does the variability of the B cell population kind of work with this clonal hematopoiesis theory? Dr Coleen McNamara: Well, it's interesting that you ask that because that's actually another direction within the lab. So we're collaborating with Dr Walsh and Jose Fuster, who was the first author on that Science paper. And we think, and in particular related to Aditi's work, that this particular subset of B cells has quite a propensity for clonality. And what she was actually able to show is, in terms of the B-1a cells within the peritoneal cavity, when their complementarity determining region three was sequenced, which is the main region responsible for recognizing the antigen-in 70% of the single cells that were sequenced, it was identical. So that actually is quite clonal. Dr Cindy St. Hilaire: Yeah. So essentially if it was random, you would expect those numbers to be much lower. Much more variable. Dr Coleen McNamara: Absolutely. But yet in the bone marrow, we saw much less of any given sequence being overrepresented. And in addition, there was evidence that there was modification in the antibody repertoire in adult life. Sort of suggesting and getting back to your earlier questions, that it actually may be atherogenic stimuli or hyperlipidemia that could be stimulating selection of other B cell clones. Dr Cindy St. Hilaire: Interesting. So we have a lot of chicken and egg questions to ask for the future. Dr Coleen McNamara: Yeah, exactly. And we're really getting into that space because we do think that the subtype of immune cell lends itself to clonal expansion. Dr Cindy St. Hilaire: I guess I want to end with one question about the translatability of some of your findings. So the last figure, figure seven, you show an inverse relationship between the level of CXCR4 on these B-1 cells with increasing plaque burden. And essentially I think the analysis you did suggests that it was actually very predictive, even more so than lipid levels. So is there base for this as a biomarker of sorts do you think moving forward? Dr Aditi Upadhye: Yeah, I think that's how we'd like to move forward in the lab is to look at how CXCR4 might be atheroprotective on these B-1 cells. And if we can find a good preclinical model to test that and see how it's atheroprotective in a more mechanistic way, that would be great. I think also that our ability to show that increasing CXCR4 on mouse B-1 cells and getting them to increase their localization to the bone marrow and increase IgM production, that also indicates that this could be feasible. But whether or not that can be atheroprotective is a question for the future. Dr Cindy St. Hilaire: That's great. Well thank you so much for taking the time speaking with me today. This was an amazing story with very cool implications for the future, and Aditi, I look forward to following your bright career in the future. Dr Aditi Upadhye: Thank you so much for the opportunity. Dr Coleen McNamara: Thank you. Dr Cindy St. Hilaire: Thank you. Well, that's it for our highlights from the October 25th and November 8th issues of Circulation Research. Thank you so much for listening. This podcast is produced by Rebecca McTavish, edited by Melissa Stoner, and supported by the Editorial team of Circulation Research. Some of the copy texts for the highlighted articles was provided by Ruth Williams, and I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your source for the most up to date and exciting discoveries in basic cardiovascular research.
In this episode, Kym and Dr. Christopher Park discuss facelifts, facial rejuvenation, neck lifts, and maintaining healthy facial skin. While the facelift has been considered the linchpin to everything plastic surgeons use, there are now many surgical and non-invasive procedures to lift, enhance, and tighten the face and neck. So, what is facial rejuvenation? Facial rejuvenation is a harmonious approach to looking at and enhancing the whole patient aesthetic from the hairline to the collarbone and then using 1 or a combination of procedures for an intended plastic surgery outcome. Dr. Park details many of the medical options that are available to plastic surgery, cosmetic, and reconstructive patients, plus the ins and outs and benefits of these choices. Please LIKE Plastikos on Facebook Key Takeaways 1. A facelift and facial rejuvenation are not the same things. 2. A facelift is a procedure that addresses the lower half to 2/3 of the face. 4. Facial rejuvenation is a term to mean Dr. Park is looking at the whole aesthetic from the hairline to the collarbone 4. Facial rejuvenation is not altering your looks but enhancing your looks. 5. Recovery time from a facelift or facial rejuvenation surgery will be 10-14 days. 6. Patients must be nicotine-free for weeks before plastic surgery. 7. Nicotine rapidly ages the skin by causing blood vessels to spasm. 8. Dr. Park wants a natural look result from a facelift or facial rejuvenation not a pulled tight or windswept look. 9. The Mid 50's is a great age to consider your first facial rejuvenation. 10. Facial rejuvenation can include surgical and non-surgical options like lasers, fillers, injectables, and chemical peels. 3 Most Common Skin Destroyers 1. Life and days living 2. The Sun 3. Smoking and nicotine Need A Consultation or Appointment with Dr. Park? To set up an appointment with The Park Clinic staff call 251.445.8888 or click here >>> Dr. Park Says: A facelift is one procedure and addresses the lower half to two-thirds of the face. - Dr. Christopher Park Facial rejuvenation is many procedures from the hairline down to the collarbone. - Dr. Christopher Park I'm going to evaluate the face and neck usually together a facelift almost always includes a neck lift unless it's a mini facelift. - Dr. Christopher Park These are not Hollywood facelifts. We won't make you look different like you're now in the Witness Protection Program. I'm just improving things. - Dr. Christopher Park It's not changing your look; it's enhancing your look. - Kym Anderson My goal is always natural facial rejuvenation essentially on average trying to take ten years off of your age. Not to make you look like a different person. - Dr. Christopher Park Traditionally people used to wait too long in my opinion late 60s early 70s and come in and they had a very dramatic change which was great except it was so dramatic everyone notices. - Dr. Christopher Park I think 55 is an excellent age to consider your first facial rejuvenation. - Dr. Christopher Park As we age our skin on the nose tends to thicken especially patients with rosacea. - Dr. Christopher Park I'm not trying to convince people to do more than they want to do, but people have no idea all these little things we can do. - Dr. Christopher Park The more sun damage you get, the more you damage the elastin and the collagen in your skin. Elastin is a protein that makes things tighten up, and it is damaged by the sun. Smoking magnifies skin issues all that I just said about the sun-times 100. We can help prevent damage; then you can help rebuild the skin with a good skincare regimen. Cervicofacial Rhytidectomy, It's a big word but what that means is - "cervico" means neck and then face. A face and neck together and rhytidectomy is essentially wrinkle removal. Gone are the days where a facelift is just removing some skin. We are going to do a deeper support system. Our goal is for you to hardly remember that we did anything with your face. We want you to look good, younger, rested, and better, and not anything weird. I require people to be completely nicotine free for six weeks before surgery and the longer, the better. And so that's nicotine-free. So even vaping, nicotine gum, and nicotine patches are bad.
Die 3 Hautschichten haben unterschiedliche Funktionen. Wie wird die Haut am besten versorgt.
In this episode Nurse Paula Young talks about what the Vampire Facial® (https://www.vampirefacial.com) procedure is and isn't and why it's one of the most sought after facial treatments by celebrities.
If you follow me on any of my social media platforms, you may know I LOVE the Rollga Foam Roller. Since I started using the Rollga, I have educated myself as to WHY we all need to use some sort of myofascial release tools (there are many, by the way!). My favorite so far, is the Rollga and the Helo by Rollga. These two tools have contours to help break up the fascia and releases any tension, pain, and tightness that I feel going on in my body. Now this episode is not all about the Rollga, it's about fascia. I wanted to educate you on how important this topic is, why we need to have fascial fitness. We all want to move better, feel better, and feel less stress in the body, am I right? Well, this is WHY we need to give myofascial release a try. What is fascia? Here is a little idea what you may hear in this episode:Fascia provides the protective sheath around our entire body as a whole and also surrounds each organ and muscle for protection from outside trauma. Our fascia also plays an important supportive role to the musculoskeletal system by enabling us to perform functional activities like going from sitting to standing and being able to walk, jump and run. When you have fascial adhesion and distortions, this can cause poor blood flow, weaker nerve impulses, limited flexibility and range of motion, and a host of other physical ailments.Why we need to move our fascia?1. When the fascia is tight, it can constrict the nerves and actually block off the nerve signal. 2. Have nagging pain in your body? So much pain, tightness, and discomfort is unnecessarily caused by distorted fascia. 3. Our body will feel younger. The condition of our skin can be affected by the state of our fascia. Not many people understand the impact of blood and fascia, and how it relates to the quality of our skin. Elastin and Collagen are two proteins which are essential to maintaining healthy, youthful skin. 4. Seriously, this will help those dimples, too! Believe it or not, even those pesky dents and dimples, that we all know as “cellulite” are also due to unhealthy fascia! Most people think cellulite is a fat issue, when in reality it is caused by distortions in your connective tissue - fascia!Okay, enough about that. Take a listen. I promise you will learn some good information! Want the Rollga or Helo? You can get it here: http://www.shareasale.com/r.cfm?B=1006306&U=698163&M=71881&urllink=Want more information about Dayna? Find her here:www.daynadetersfitness@gmail.com
If you follow me on any of my social media platforms, you may know I LOVE the Rollga Foam Roller. Since I started using the Rollga, I have educated myself as to WHY we all need to use some sort of myofascial release tools (there are many, by the way!). My favorite so far, is the Rollga and the Helo by Rollga. These two tools have contours to help break up the fascia and releases any tension, pain, and tightness that I feel going on in my body. Now this episode is not all about the Rollga, it's about fascia. I wanted to educate you on how important this topic is, why we need to have fascial fitness. We all want to move better, feel better, and feel less stress in the body, am I right? Well, this is WHY we need to give myofascial release a try. What is fascia? Here is a little idea what you may hear in this episode:Fascia provides the protective sheath around our entire body as a whole and also surrounds each organ and muscle for protection from outside trauma. Our fascia also plays an important supportive role to the musculoskeletal system by enabling us to perform functional activities like going from sitting to standing and being able to walk, jump and run. When you have fascial adhesion and distortions, this can cause poor blood flow, weaker nerve impulses, limited flexibility and range of motion, and a host of other physical ailments.Why we need to move our fascia?1. When the fascia is tight, it can constrict the nerves and actually block off the nerve signal. 2. Have nagging pain in your body? So much pain, tightness, and discomfort is unnecessarily caused by distorted fascia. 3. Our body will feel younger. The condition of our skin can be affected by the state of our fascia. Not many people understand the impact of blood and fascia, and how it relates to the quality of our skin. Elastin and Collagen are two proteins which are essential to maintaining healthy, youthful skin. 4. Seriously, this will help those dimples, too! Believe it or not, even those pesky dents and dimples, that we all know as “cellulite” are also due to unhealthy fascia! Most people think cellulite is a fat issue, when in reality it is caused by distortions in your connective tissue - fascia!Okay, enough about that. Take a listen. I promise you will learn some good information! Want the Rollga or Helo? You can get it here: http://www.shareasale.com/r.cfm?B=1006306&U=698163&M=71881&urllink=Want more information about Dayna? Find her here:www.daynadetersfitness@gmail.com
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 07/07
Ziel dieser Arbeit war es, mittels Licht- und Rasterelektronenmikroskopie sowie immunhistochemischen Methoden, die Morphologie der Hornhaut im tierartlichen Vergleich an Hand unserer Haussäugetiere detailliert zu beschreiben. Für die Untersuchungen wurden die Hornhäute von 28 Schweinen, 11 Rindern, 2 Ziegen, 6 Pferden, 4 Hunden und 5 Katzen verwendet. Speziesspezifische Besonderheiten wurden bildlich dokumentiert und zur Verdeutlichung tabellarisch dargestellt. Die Hornhaut unserer Haussäugetiere baut sich aus dem Hornhautepithel, dem Stroma, der Descemetschen Membran und dem Hornhautendothel auf. Eine Bowmansche Membran konnte nicht dargestellt werden. Die Fleischfresser besitzen verglichen mit den Huftieren eine deutlich dünnere Hornhaut. Insbesondere das dreischichtige Epithel (Stratum basale, Stratum intermedium und Stratum superficiale) besteht bei den Fleischfressern aus einer kleineren Anzahl an Zelllagen. Die Cytokeratine 1, 2 und 3, als Bestandteile des Zytoskeletts, konnten immunhistochemisch bei allen untersuchten Tierarten, insbesondere im Stratum superficiale des Hornhautepithels, nachgewiesen werden. Das vom Zentrum aus an Höhe abnehmende Hornhautepithel lässt unter dem Rasterelektronenmikroskop auf der Oberfläche der polygonalen Epithelzellen feine Membranausstülpungen erkennen, die sich beim Fleischfresser in Form von kurzen Microvilli darstellen. Das Pferd, Rind und Schwein weisen längere Microplicae auf, die bei der Ziege einzelne ringförmige Kringel bilden. Eine beim Pferd und bei den Wiederkäuern auch epithelial zu findende Pigmentierung, lässt sich im Stroma tierartenübergreifend im Bereich des Limbus erkennen. Mit Ausnahme des anterioren Bereichs weisen die im Stroma liegenden Keratozyten einen geordneten, parallelen Verlauf auf. Tierartliche Unterschiede liegen in der Ausbildung der Descemetschen Membran vor. Das Pferd besitzt die dickste Descemetsche Membran, wohingegen das Schwein die am schwächsten ausgebildete Membran vorweist. Endothelial produziertes Kollagen Typ VIII bildet einen Bestandteil der hexagonalen Gitterstruktur der Descemetschen Membran, wodurch die Elastizität der Hornhaut möglicherweise mitbestimmt wird. Der Nachweis von Elastin ist hingegen im Hornhautgewebe negativ verlaufen. Das einschichtige Hornhautendothel besteht aus Zellen von hexagonaler Form. Es konnte gezeigt werden, dass die Endothelzellen das Membranprotein AQP1 enthalten, das auch in den Keratozyten in tierartlicher Variation exprimiert wird. Hingegen kann das AQP5 ausschließlich im Hornhautepithel identifiziert werden. Durch APQ1 und APQ5 wird der für die Transparenz der Hornhaut wichtige relative Dehydratationszustand aufrecht erhalten. Mit Claudin-1 konnte im Hornhautepithel und -endothel ein tight junctions-bildendes Zellverbindungsprotein markiert werden. Mit Antikörpern gegen p63 sowie PCNA und PHH3 wurde untersucht, wie sich die Hornhaut erneuert. Die Ergebnisse machen deutlich, dass eine Zellerneuerung überwiegend epithelial stattfindet. Limbal befindet sich bei allen untersuchten Tierarten im Stratum basale ein Stammzellreservoir, das bei den Fleischfressern entlang des Hornhautepithels durch einzelne p63-positive Zellen ergänzt wird. Die mittels PCNA und PHH3 dargestellten mitotischen Zellen sind ebenfalls im Stratum basale lokalisiert.
Dr. Cate Shanahan hits the Q&A hard, offering interesting commentary on a variety of topics, especially those relating to hormones and longevity markers. Cate explains how one's level of elastin is a major predictor of lifespan. Elastin is typically considered an important component of healthy skin. Losing elastin and collagen (a form of elastin that is also a major element of healthy skin) cause wrinkles, an obvious sign of aging. Elastin, however, is present in other cells such as those in joints and arteries. Losing elastin accelerates aging (arteries become stiffer and less resilient; joints become creakier and less fluid) and hastens demise. Across species, the typical half-life of elastin is a lifespan predictor. For example, the half-life of elastin in a dog is 10 years whereas it's 75 years in humans. One develops a lifetime supply of elastin by age 20, which makes childhood and teen years critical for obtaining the optimal nutrition to fully realize elastin production potential. Pro-inflammatory lifestyle habits have a destructive effect upon elastin. On the other hand, consuming glycosaminoglycans, as found in bone broth and meat on the bone, can have a positive effect on elastin by helping maintain its structure (glucosamine supplements have been reported to serve this purpose too, but they are not as potent or comprehensive as the elastin supporting compounds found in whole food sources).A question comes in about hormone replacement therapy to combat aging and Cate comments about the proven effect of exogenous hormones to preserve elastin, which has distinct anti-aging effects. She also comments on its potential drawbacks, such as an elevation in triglycerides and blood pressure, as well as hot flashes from increased sensitivity to cortisol. Cate speculates that cheating nature will always have some repercussions to consider. While hormone manipulation could elevate peak performance potential, it could come with a consequent negative effect on longevity.
Yong Ho Bae and Richard Assoian discuss a signaling pathway that causes cells to stiffen their cytoskeletons and proliferate when placed on stiff substrates.
Elastin and Collegen. How to build more of it to look younger. and Q and A
Fakultät für Physik - Digitale Hochschulschriften der LMU - Teil 01/05
Molecular machines are at the ultimate limit of miniaturization. Living organisms provide a variety of examples for such molecular machines, but in order to utilize and to control them, they need to be interfaced with the macroscopic world. On the other h and, there are synthetic molecular machines. Some have been interfaced already but usually in high vacuum at very low temperatures, which is clearly not desirable for technical applications. In this thesis, AFM-based single molecule force spectroscopy (S M FS) was utilized to investigate the mechanical change in single synthetic molecules upon environmental changes (external stimuli) in liquid environment at room temperature. The molecules are either from theory or from bulk experiments supposed to be ab le to convert such an external stimulus into mechanical work, which is a prerequisite for molecular motors. Three different types of molecules and various external energy inputs were investigated which led to the realization of a light driven synthetic mo le cular machine: - Polyelectrolytes should, by OSF-theory, change their persistence length (and therefore the overall length at a constant force) with the Debye screening length of the solvent (which is manipulated by the salt concentration). Therefore, t he elasticity of the polyelectrolyte polyvinylamine, which could be covalently attached to the substrate and the AFM tip, was investigated in dependence on the salt concentration. It was found that the dependence of persistence length on salt concentr atio n is much smaller than expected from OSF-theory, which made this system less attractive for a molecular machine, but led to new theoretical insights. - The adhesive properties of polyelectrolytes onto charged solid supports in aqueous solution are a subj ect of current research in industry and academia. A manipulation of polymer – substrate adhesion, e. g. at an AFM tip, could lead to a molecular 'grab and release' device. Therefore, the desorption force of single polyvinylamine-molecules from solid suppo rts was investigated. Polyvinylamine was physisorbed to a glass substrate and covalently attached to the cantilever. Then, the charge-charge interaction was manipulated by variation in salt concentration and polymer charge. While this has not led t o a sin gle molecule device yet, it gave new insights into the desorption of polyelectrolytes from charged substrates. The measurements performed here revealed that van der Waals forces and other non-covalent chemical interactions such as hydrogen and coo rdinative bonds can by far outweigh the electrostatic coulomb force (namely at short distances), and are therefore a more promising candidate for the tuning of adhesion forces. - Elastin-based polypeptides have proven various kinds of energy conversion i n cross-linked bulk samples. The mechanism is based on a hydrophobic folding transition, which can be manipulated by temperature, salt, pH, electrochemistry, and/or by the composition (hydrophobicity) of the polymers. The difference between the folded and random state could be detected and investigated here at the level of individual polymer chains and characterized by the force-extension traces of the two polypeptides (GVGVP)nx251 and (GVGIP)nx260. Because of their different hydophobicity their folding t emperatu res lie above and below room temperature, respectively. With the polypeptide (GVGIP)nx260 the folded state was investigated extensively. All observations support the conjecture, that intermolecular aggregation dominates intramolecular aggregatio n. This i s further supported by the finding that neither a change in temperature nor the treatment with sodium dodecyl sulfate or guanidinium hydrochloride could force any of the two polypeptides from the folded to the random state or vice versa within a n experime nt, which in turn would be a prerequisite for a polypeptide based molecular motor. - The most successful approach to building an AFM-interfaced molecular machine was in taking advantage of reversible configurational changes in azobenzene poly mer molecul es upon irradiation with light. Azobenzene can be driven from a shorter 'cis' to a longer 'trans' configuration by illumination with l = 420 nm light and vice versa by l = 365 nm. In order to utilize azobenzene, a setup had to be developed and built, whic h allows for the coupling of light into the AFM experiment. Total internal reflection geometry was necessary to avoid any artifacts due to direct effects of the light on the cantilever. A polypeptide chain with multiple functional azobenzene units was cov alently fixed to both, a gold coated cantilever and a flint glass substrate. In the force-extension traces lengthening as well as shortening of the polyazopeptide was observed even under an applied external force. This is not only a proof of principle for the first single molecule motor interfaced to the macroscopic world, but also generates discussion concerning potential energy landscapes under external force.
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