Podcasts about homa ir

Story at-a-glance When cells become insulin resistant, they struggle to use glucose for energy, forcing your body to convert excess glucose into fructose through the sorbitol pathway — a "backup plan" that prevents immediate crisis but causes long-term damage Modern diets high in refined sugars and seed oils (like soybean and corn oil), combined with exposure to environmental toxins and plastics, have led to an estimated 99% of Americans having some degree of insulin resistance The HOMA-IR blood test provides an early warning for insulin resistance, with scores above 1.0 indicating potential metabolic issues that should be addressed through lifestyle changes Contrary to popular belief, white rice may be healthier than brown rice for people with insulin resistance, as brown rice's fiber can feed harmful gut bacteria and its higher omega-6 content can promote inflammation Your body requires around 200 to 250 grams of carbohydrates daily, and severely restricting carbs can trigger stress hormones like cortisol that break down muscle tissue to create glucose

Story at-a-glance Research shows mangoes significantly improve insulin sensitivity in people with chronic low-grade inflammation by activating genes that enhance the body's natural antioxidant defenses A 12-week study found that consuming freeze-dried mango pulp daily led to reduced blood glucose levels in obese adults At the cellular level, mango polyphenols activate the AMPK signaling pathway — the cell's master metabolic switch — promoting fat breakdown while suppressing the formation of new fat cells Regular mango consumption demonstrates measurable benefits for insulin function, with study participants showing lower fasting insulin concentrations and improved HOMA-IR scores compared to control groups Mango polyphenols help reduce inflammation by decreasing proinflammatory cytokines, suggesting benefits for preventing obesity-related diseases

Ads for Ozempic, Wegovy, and Zepbound are all over our televisions (at least here in the US). But are these injectables really the key to losing weight and keeping it off? In this episode, I'm digging into all of the science surrounding these popular weight-loss drugs, including - the differences between each of them - how they work (and don't work) - the unwanted side effects that come from using these medications - natural ways to increase your body's production of GLP-1 ... and more! --- Show Notes: References: Coursework from Master's in Human Nutrition & Functional Medicine Program at the University of Western States Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Weight Loss Medications: GLP-1 Agonists and How They Work How Much Does Ozempic Cost? With & Without Insurance Zepbound vs. Ozempic: 5 Differences Between These Weekly Injections What Are Incretin Mimetics, and How Do They Affect Weight Loss, Blood Sugar, and Type 2 Diabetes? Strategies for minimizing muscle loss during use of incretin‐mimetic drugs for treatment of obesity The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity Anti-obesity effects of Yerba Mate (Ilex Paraguariensis): a randomized, double-blind, placebo-controlled clinical trial The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial) Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism --- 135: What You Should Know Before Starting Ozempic Sign up for a 1:1 Discovery Call Join the Compass Method DIY Program Jump inside my Rock the Bloat Minicourse Get my Core-Gi Workout Program with the exclusive listener discount! Join my Brain Rewiring Masterclass You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

In this insightful interview, PhD researcher Isabella Cooper dives deep into the science of ketosis and its impact on health. She discusses how it's not just about maintaining high levels of ketones but also about the quality and source of those ketones. Isabella highlights the importance of avoiding unhealthy fats and proteins like soybean oil, canola oil, and pea protein isolate while following a ketogenic diet. Discover the latest research findings on cycling in and out of ketosis and how it can influence your overall health. Learn about the molecular components that truly matter when optimizing your metabolic state and achieving sustainable health outcomes. Tune in to explore the fascinating world of metabolic health with Dr. Isabella Cooper and uncover practical tips for enhancing your ketogenic journey! *Experts Featured* Isabella Cooper, PhD University of Westminster https://www.foreveryounggroup.com/ https://www.facebook.com/bellamitochondria X: @I_mitochondria *Related Papers* _Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females_ https://www.mdpi.com/1422-0067/24/21/15621 _Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females_ https://www.mdpi.com/2227-9059/12/7/1553 *Resources* Metabolic Mind's Families & Peers page: https://www.metabolicmind.org/families-and-peers Clinician Directory: https://www.diagnosisdiet.com/directory Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#AlternativeTreatment#MedicalKeto#KetogenicTherapy #MetabolicHealth#Keto#Longevity

Episode 2495 - On this Friday's show Vinnie Tortorich speaks with Dr. Cate Shanahan about her new book about oxidative stress, the downside of working against nature, and more. https://vinnietortorich.com/2024/05/working-against-nature-dr-cate-shanahan-episode-2495 PLEASE SUPPORT OUR SPONSORS YOU CAN WATCH ALL THE PODCAST EPISODES ON YOUTUBE - Root Causes of Oxidative Stress Cate first noticed issues in pro basketball players. (2:30) What she found out was a symptom of metabolic problems. Dr. Shanahan was one of the early voices who emphasized the toxicity of seed oils. (6:00) She explains how she started paying attention to seed oils. Her background in biochemical engineering transitioned to medical school; however, her personal medical issues led her to a deep dive into health. Her book “Dark Calories” is available in Vinnie's Book Club . She explains the meaning behind the name. (13:00) Metabolic disease is rampant. Being “hangry” is a sign of insulin resistance, which is a stage of metabolic disease. New standards of testing need to happen; she's a big believer in using the HOMA-IR testing. They discuss oxidative stress and seed oils and how they are included in many things. (20:00) She defines what she has named as “The Hateful 8.” It's a similar effect of oxidation as cigarette smoking. Vinnie asks her about her list called the “Delightful Dozen.” (27:00) She hopes to get more doctors on board in expanding the message regarding various oils and the effects of oxidative stress. (35:00) Free radical particles are caused by oxidative stress; vegetable oils are “oxidative stress in a bottle.” (42:30) Empty calories from processed foods and sugars can cause them too. She also challenges the use of protein powders. (46:00) Respecting Nature and how it works is important; trying to “outsmart” nature is a dead-end game. (54:00) The energy model of insulin resistance has to do with your body not being able to use its body fat as fuel. (56:00) Her book “Dark Calories” provides information that can help you reduce cravings while you heal from insulin resistance. (57:00) Working Against Nature Vinnie asks Cate how can people do better. (59:00) She provides several practical food suggestions. “Root cause” knowledge will help you. They pivot to cholesterol. (1:04:00) Cholesterol is a nutrient—it is a building block of cells and hormones. The egg is the most complete package of nutrients you can get. There are plenty of untruths in the “Game Changers” film; they elaborate. (1:06:00) You need to know what is both good and bad about the medical system. The conversation on nutrition is the American College on Lifestyle Medicine, which is a Seventh-Day Adventist group promoting their religious stance on eating and lifestyle. (1:10:00) Vinnie asks Cate's take on GLP-1s. (1:14:00) She is against them for many reasons; the first one is that those drugs are working against Nature. Acute muscle loss is happening to patients on drugs like Ozempic; remember your heart is a muscle. She lists other concerns she has about them. There's a new NSNG® Foods promo code you can use! (53:00) The promo code ONLY works on the NSNG® Foods website, NOT on Amazon. Vinnie's new documentary "Dirty Keto" is out! Go to to get it at ! [the_ad id="20253"] PURCHASE BEYOND IMPOSSIBLE (2022) The documentary launched on January 11! Order it TODAY! This is Vinnie's third documentary in just over three years. Get it now on Apple TV (iTunes) and/or Amazon Video! Link to the film on Apple TV (iTunes):  Then, Share this link with friends, too! It's also now available on Amazon (the USA only for now)!  Visit my new Documentaries HQ to find my films everywhere: REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter!  

Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News Topic: J-shaped association between LDL cholesterol and cardiovascular events: A longitudinal primary prevention cohort of over 2.4 million people nationwide Show Notes: The Great Menopause Myth: The Truth on Mastering Midlife Hormonal Mayhem, Beating Uncomfortable Symptoms, and Aging to Thrive Paperback – September 10, 2024 Homeschoolcoffee.com They donate $1 from every bag of coffee to the Home School Legal Defense Association Chelation Therapy Nick Norwitz YouTube Channel Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases Questions:    Glucose Robert writes: Obi-Wan your our only hope. Have consistently high blood sugar on a full carnivore diet. Average readings around 100. After a 36 hour fast will often still be close to 100. Two days of fasting and the glucose will finally drop mid eighths and low ninetys. Post prandial readings are often in the low ninetys or high eighties. Which is always amusing since post workout readings are often 120 or higher. A little insulin goes a long way. Concerned about the AGE from constantly high blood sugar. This seems way beyond adaptive glucose sparing or the dawn effect. Signed, Mystified in New Mexico. (The details. Carnivore for four years. 99% of diet is fish, flesh and eggs. Cook in butter and lard. Only exogenous sugar is lactose in occasional yoghurt or coffee. 72 yo with around 15% fat and decent amount of lean muscle mass. Active, do weights and walk about 20 miles a week. O.K. sleep for my age. HbA1c 5.6, however HOMA-IR is 1.1. lipids are typically of a LMHR. Have used four different glucose meters over the years. Currently using two Keto-Mojos.)   Lowering Coronary Calcium Score Bret writes: Hello! Wondering if you know of any potential ways to lower your coronary calcium score. Personally, I'm 56 years old, and 44 of those years were spent consuming the standard American diet. (I've been strict Paleo since.) I'm sure that those 44 years produced 2 coronary calcium scores (3 yrs ago, and 2 yrs ago) that came in around 48 (total) and 47, respectively. Obviously, my goal is zero, but I'm not sure if there is any way to lower it. My functional med doctor recommended nattokinase, which I've been taking religiously, and it may (or may not) be the reason for the lowering of my score by 1 point over those 2 years. Anyway, I'm looking for any tips you may have for lowering my coronary calcium score, if they indeed exist. Thoughts? (Long time listener - thanks for all you do!) Bret   Trying to Understand Macro Nutrients Darren writes: Hi again from Tasmania. Just a brief question regarding protein. If I burn approximately 2500 cal a day, should that be made up of carbs and fat only? Because I assume that the 140 grams of protein I eat will be used for all of the processes it normally would do. How can protein be included in calories if it's not used for energy? I'm Not sure if this makes any sense. Love the podcast. Thanks Darren from taasie.   Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte drink mix packets and the new LMNT Sparkling electrolyte performance beverage! Click here to get your LMNT electrolytes Transcript: Coming soon! 

A recent analysis of NHANES data from 2021 found that 40% of US adults aged 18 to 44 are insulin-resistant (IR) based on HOMA-IR measurements. While obesity rates have increased considerably over the past 2 decades, this rapid increase in prevalence was not only associated with increased adiposity. Hypertension, dyslipidemia, and limited physical activity also increased insulin resistance. PCOS and IR are intimately tied, although not all PCOS patients will have clinical or biochemical evidence of IR. And remember this clinical pearl: IR is NOT included in the diagnostic criteria for PCOS. According to published estimates, insulin resistance may be found in 44% to 90% of people with PCOS (the widespread percentage is due to various testing modalities and PCOS phenotypes). Screening for IR is an important aspect of preventative health maintenance in PCOS patients, and all patients deemed high risk. In this episode, we will provide an evidence-based review of the various modalities for IR screening and diagnosis.

Lisa talks to Dr. Paul Kolodzik, the man behind metabolicmds.com, who discusses  fasting, weight loss, HOMA/IR and other factors for getting metabolically healthy.     WEBSITE: https://www.metabolicmds.com/     INSTAGRAM:  https://www.instagram.com/metabolicmds/     BOOK:  The Continuous Glucose Monitor Revolution: Lose Weight, Look Great, and Live Longer with Continuous Glucose Monitoring by Dr. Paul Kolodzik https://amzn.to/47cFEd6     EPISODE SPONSOR:  https://www.ralstonfamilyfarms.com/     EPISODE SPONSOR:  https://dogtalktv.com/     EPISODE SPONSOR:  https://marlsgate.com     EPISODE SPONSOR:  https://compoundingatcornerstone.com/       LISA'S LINKS:     Lisa Fischer Said Academy:  https://lisafischersaid.com/academy/     Website:  lisafischersaid.com     For more information on group intermittent fasting  coaching with Lisa, email fasting@lisafischersaid.com     For more information on one-on-one or group health coaching with Lisa, email healthcoaching@lisafischersaid.com     Podcast produced by clantoncreative.com

Welcome to this week's episode of Fast. Feast. Repeat. Intermittent Fasting for Life, with Gin Stephens and Sheri Bullock.To make a submission for the podcast, go to fastfeastrepeat.com/submit. We are a community-driven podcast, and we look forward to sharing your questions, success stories, non-scale victories, IF tweaks, motivational quotes (and more!) on each episode of the podcast. Resources used in today's episode:Beautycounter: https://www.beautycounter.com/sheribullock Check your insulin here: https://www.fastfeastrepeat.com/walkinlab HOMA/IR: https://thebloodcode.com/homa-ir-know/ NIH Potassium Fact Sheet: https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/ Feeding the Hungry Heart, Breaking Free from Compulsive Eating: https://amzn.to/46c8WbA Go to fastfeastrepeat.com to see Gin's and Sheri's favorite things, and to shop with us. Every purchase you make through links on our website help to support this podcast so we can keep bringing you episodes each week. Are you ready to take your intermittent fasting lifestyle to the next level? There's nothing better than community to help with that. In the Delay, Don't Deny community we all embrace the clean fast, and there's just the right support for you as you live your intermittent fasting lifestyle. Connect with both Gin and Sheri in the community, as well as thousands of other intermittent fasters who are there to support you along your journey. If you're new to intermittent fasting or recommitting to the IF lifestyle, join the 28-Day FAST Start group. After your fast start, join us for support in The 1st Year group. Need tips for long term maintenance? We have a place for that! There are many more useful spaces beyond these, and you can interact in as many as you like.Visit ginstephens.com/community to join us. An annual membership costs just over a dollar a week when you do the math. If you aren't ready to fully commit for a year, join for a month and you can cancel at any time. If you know you'll want to stay forever, we also have a lifetime membership option available. IF is free. You don't need to join our community to fast. But if you're looking for support from a community of like-minded IFers, we are here for you at ginstephens.com/community.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5913143/advertisement

Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here!   FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins!   THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's episode, Dr. Scott and Tommy discuss a research article on low carbohydrate intake and insulin resistance in healthy individuals. They emphasize personalized fasting and dietary choices, highlighting the importance of body composition and metabolic flexibility. They also stress the value of a supportive environment for fasting success and advise listeners to stay committed to their journey while making mindful food choices.   Show Transcript: www.thefastingforlife.com/blog   Nutrisense CGM LINK to Discount  - Get $30 off and one-month free dietician support with the PROMO CODE “FASTINGFORLIFE” www.nutrisense.io/fastingforlife Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here!   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them   Article Links: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061153/ https://pubmed.ncbi.nlm.nih.gov/33103448/ https://thebloodcode.com/homa-ir-know/ https://pubmed.ncbi.nlm.nih.gov/27126885/  

Approximately 93% of the population is affected by an issue that predicts heart disease about 10 years before you have elevated cholesterol—and very few people realize they have it.  This same condition is the precursor to several common chronic illnesses, and your doctor probably isn't testing for it.  The good news is, this condition is almost 100% treatable, preventable, and reversible if you know what to do.  In today's episode, you're going to learn what this epidemic is, why it's critical to your health, and what you can do to avoid being another statistic. Join me and weight loss, metabolism, and anti-aging specialist and board-certified nutritionist Jonny Bowden for an eye-opening conversation about how to safeguard your health, now and for years to come.  Full show notes: https://jjvirgin.com/jonny Learn more about Jonny Bowden: https://www.jonnybowden.com Subscribe to my podcast: http://subscribetojj.com Read my book, The Sugar Impact Diet: https://store.jjvirgin.com/collections/books/products/sugar-impact-diet-paperback-book Read The Great Cholesterol Myth: https://amzn.to/43XsVJa Read The 150 Healthiest Foods on Earth: https://amzn.to/3OOZogt Study: Metabolic Syndrome and Related Disorders, Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016: https://pubmed.ncbi.nlm.nih.gov/30484738/ HOMA-IR calculator: https://www.mdcalc.com/calc/3120/homa-ir-homeostatic-model-assessment-insulin-resistance DEXA scan: https://dexascan.com/ YourLabWork advanced lipid panel: https://yourlabwork.com/jj-virgin/ Find it under cholesterol tests/heart health YourLabWork fasting insulin test: https://yourlabwork.com/jj-virgin/ Find it under sugar metabolism & diabetes screening Study: Current Opinion in Clinical Nutrition and Metabolic Care: Sleep and Obesity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632337/ American Diabetes Association: https://diabetes.org/ Reignite WellnessTM All-in-One Shakes: https://store.jjvirgin.com/collections/shakes Catalina Crunch Keto Protein Cereal: https://amzn.to/47jLv0X Rockport Test calculator: https://www.sport-fitness-advisor.com/rockport-test-calculator.html Learn more about Blue Zones: https://www.bluezones.com/ Podcast: What Causes Obesity? with Dr. Richard Johnson: https://jjvirgin.com/main-podcast/what-causes-obesity-with-dr-richard-johnson-ep-490/ Get Jonny's 7 Uncommon Daily Habits to Turbocharge Weight Loss & Energy: https://rockwell-health.com/7habits

Insulin resistance can lead to numerous health issues, but how do you know if you have it? Find out about HOMA-IR, the best test for insulin resistance. In this podcast, I'm going to tell you about the best test for insulin resistance called the Homeostatic Model Assessment of Insulin Resistance, or HOMA-IR.

Dr. Fiona McCulloch discusses Managing a Healthy Menopause at the Functional Medicine Discussion Group meeting on April 27, 2023 with moderator Dr. Ben Weitz. [If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]    Podcast Highlights 5:35  Perimenopause usually starts around age 39 till 55 or so and this is when we start seeing irregular cycles and lots of symptoms and increases in chronic health risks.  Perimenopause is a time of fluctuation.  Women are born with all of the follicles in their ovaries for their entire life. the follicles house the eggs and each egg is housed by cells that make hormones.  Over the lifespan the pool of follicles decrease and when you get to the end of the reproductive years, there are far fewer follicles and hormones are released abnormally and inconsistently.  During a normal menstrual cycle the granulosis cells in the inner follicle make estrogen and when the egg comes out, it ovulated and the shell of the egg makes progesterone for two weeks.  During perimenopause we have follicles on their last legs and they make estrogen all the time but not in a normal pattern and there is almost no progesterone.  The adrenals do make small amounts of progesterone but the ovaries make massive amounts of progesterone.  Perimenopause is marked by wildly fluctuating wild estrogen levels up and down and pretty much no progesterone for the majority of the time. 10:37  Diagnosis of Perimenopause. The pituitary gland is involved with the complex control of ovulation.  When estrogen levels start to drop, the pituitary senses that and then sends FSH down to the ovary to make an egg and then you get increased estrogen.  When estrogen levels get irregular but generally higher, the brain will stop making FSH, so some measure FSH as a way to diagnose perimenopause. But FSH is not consistently low, so it is not a good way to diagnose perimenopause. The best way to diagnose perimenopause is not to test hormones but based on age and that the menstrual cycle gets shorter, irregular. Women will get insomnia, have mood changes, etc.  Testing can be useful for treatment but not for diagnosis.  Menopause is easy to diagnose, since it is diagnosed when it has been 12 months since the last period.  14:32  Stages of Perimenopause.  During the first stage of perimenopause, the cycles become shorter because there are less follicles and they make less anti-müllerian hormone, which slows them down from ovulating too early.  In the later stages of perimenopause we see highly unpredictable cycles and lots of heavy, long bleeding. Some of the common symptoms that may occur in menopause include hot flashes, insomnia, anxiety, depression, low libido, vaginal dryness, autoimmunity, insulin resistance, loss of bone density, increased cardiovascular risk, and increased Alzheimer's risk.    20:12  Hormone testing.  Different modalities of testing are more or less effective for different reasons. Serum or blood spot is the most common form of hormones testing and it is good at picking up topical estrogen, oral and vaginal hormones.  Topical progesterone is not seen very well in a serum test, but it is seen in a blood spot or in saliva testing.  Urine testing is good to look at the metabolites of estrogen and cortisol and Dr. McCulloch will typically use DUTCH testing.  But urine testing is not as good to monitor topical hormone replacement therapy or vaginal HRT, since this can end up in the urine directly.  Saliva is helpful to look at the diurnal rhythm of free cortisol and is good for picking up topical progesterone.  For saliva and blood spot testing she will use ZRT Labs. 24:28  Other labs that Dr. McCulloch will often order besides hormones include the following: 1. Lipids, 2. ApoB, 3. Homocysteine, 4. HOMA-IR, 5. HBA1C, 6. Glucose, 7. OGTT with insulin, 8.

Whey protein and dairy products tend to get negative press from integrative practitioners because of the "insulin-promoting" effects of whey. Interestingly, it is exactly this "insulin promoting" effect that creates positive post-parandial glucose changes in diabetic patients and likely contributes to the preservation of lean tissue in diabetic patients during dieting.  In this podcast we discuss an article by Memelink (2020) on the use of a Whey protein drink daily and after exercise in patients with type 2 diabetes and the impact the intervention had on HOMA-IR scores and lean tissue.  We also discuss an article by Smith (2020) and Miller (2021) and how these three articles contribute to our current understanding of using Whey protein in diabetic patients.  Memelink, R. G. et al. Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT. Nutrients 13, 64 (2020).   Miller, E. G. et al. Effects of whey protein plus vitamin D supplementation combined with progressive resistance training on glycaemic control, body composition, muscle function and cardiometabolic risk factors in middle‐aged and older overweight/obese adults with type 2 diabetes: A 24‐week randomized controlled trial. Diabetes Obes Metabolism 23, 938–949 (2021).   Smith, K., Davies, K. A. B., Stevenson, E. J. & West, D. J. The Clinical Application of Mealtime Whey Protein for the Treatment of Postprandial Hyperglycaemia for People With Type 2 Diabetes: A Long Whey to Go. Frontiers Nutrition 7, 587843 (2020).

In this episode you'll learn what a healthy blood insulin level is, and how to interpret your blood results.At Zivli, we advocate prevention before prescription and think it's wise to reverse risk factors before they become disease.To help you become aware of your risk factors for cardiometabolic diseases such as insulin resistance, diabetes, and heart disease, we've partnered with a lab to offer an at-home fasting insulin test, and a more comprehensive cardiometabolic panel.Our Cardiometabolic test kit measures fasting insulin, HDL-C, Triglycerides, Hemoglobin A1c, hsCRP, VLDL-C, LDL-C, and total cholesterol.To order one of these tests go to www.zivli.com/testing. You can also use blood work obtained from your doctor, but you may not have all the values discussed here.Highlights From This EpisodeWhy “normal” bloodwork numbers are not optimal. How to check your insulin levels at home. How to download a free health assessment tracker form. Optimal levels for fasting insulin, fasting glucose, glucose after a meal, hsCRP, Hemoglobin A1c, Triglycerides, VLDL, HDL, waist circumference, HOMA-IR, and Triglyceride/HDL ratio. How to calculate your HOMA-IR for insulin resistance.How to learn more about joining Zivli. Subscribe & ReviewSubscribing and leaving a rating and review are important factors in helping the Reshape Your Health Podcast and the YouTube Channel reach more people. If you haven't already subscribed, please do that today.We would also be grateful if you left a rating and review, too. In your listening app, scroll to the “Ratings and Reviews” section, then click “Write a Review” and let us know what you enjoy about our show. We appreciate you taking the time to show your support. Thank you!Resources From This Episode>> Join Zivli>> Book a Free Zivli Discovery Call>> Freebie: Weight Loss Mindset Audio Training>> Freebie: The Ultimate Food Guide>> Test Your Insulin At Home>> Health Assessment Tracker Form

Article: How the organized Left got Covid wrong, learned to love lockdowns and lost its mind: an autopsy https://thegrayzone.com/2022/03/31/left-covid-lockdowns-mind-autopsy/   EU Renews Digital COVID Pass Despite 99% Negative Public Feedback https://www.zerohedge.com/geopolitical/eu-renews-digital-covid-pass-despite-99-negative-public-feedback   Videos: 1. Psywars Documentary. – The Obama Clip (0:23) 2. Clare Daly her best speech so far . Ukraine (1:22) 3. Vitamin Authentication. Electronic pill that stays in your body & will become a 18bit Battery operated chip (1:00) 4. Is Klaus Schwab the Most Dangerous Man in the World? (15:07)  5. Kim Iversen: Inside The SECRET Bilderberg Meetings Between Spies, War Hawks And World Leaders (9:28) 6.  The great recycling LIE (what really happens to plastic) (10:44) 7.  New Rule: How the Left Was Lost | Real Time (HBO)  (8:30) HEALTH NEWS Grape consumption may offer benefits for symptomatic knee osteoarthritis Bad habits that lead to cancer, chronic disease corrected by simple lifestyle intervention The blueberry component pterostilbene has potent anti-myeloma activity Exercise makes the blood of obese people healthier People who go to bed late have less control over OCD symptoms Green tea-capsaicin-ginger combo linked to weight and metabolic improvements Grape consumption may offer benefits for symptomatic knee osteoarthritis Texas Woman's University, June 20, 2022 New research suggests that regular grape consumption may help alleviate pain associated with symptomatic osteoarthritis of the knee, and improve joint flexibility and overall mobility. Researchers attribute these potential benefits to the polyphenols found in grapes. The sixteen week clinical study, undertaken by Texas Woman's University, was designed to investigate the benefits of grape consumption on inflammation and osteoarthritis outcomes. 72 men and women with knee osteoarthritis (OA) were assigned to either consume grapes in the form of a whole grape freeze-dried powder, or a placebo powder. The study results showed that both men and women consuming a grape-enriched diet had a significant decrease in self-reported pain related to activity and an overall decrease in total knee symptoms. This beneficial effect was more pronounced in females. Additionally, age-related differences were observed: there was a 70% increase in very hard activity for those under 64 years of age consuming the grape powder, while those receiving the placebo reported a significant decrease in very hard activity. Participants over 65 years, whether consuming grapes or the placebo, reported a decline in moderate to hard activities. Evidence of increased cartilage metabolism was observed in men consuming the grape-enriched diet; they had higher levels of an important cartilage growth factor (IGF-1) than those on placebo. This protective effect was not observed in the females. T Bad habits that lead to cancer, chronic disease corrected by simple lifestyle intervention Northwestern University, June 19, 20122 Does this sound like someone you know? He or she spends too much time in front of screens, gets little exercise and eats a diet high in fat and low in fruits and vegetables. It likely sounds familiar because it describes a significant portion of the U.S. population. A new Northwestern Medicine study found that a lifestyle intervention could fully normalize these four unhealthy behaviors, which put people at risk of developing heart disease and common cancers, including breast, colon and prostate. “Our findings suggest that prevention of chronic disease through behavior change is feasible. They contradict the pessimistic assumption that it's not possible to motivate relatively healthy people to make large, long-lasting healthy lifestyle changes,” said lead author Bonnie Spring at Northwestern University Feinberg School of Medicine. With the help of a smartphone app, a wearable activity tracker, some social support from a coach and a small financial incentive, study participants made large improvements in their eating and activity habits. From a starting point of less than two servings of fruits and vegetables per day, they increased their intake by 6.5 servings per day. They decreased saturated fat intake by 3.6 percent to consume less than 8 percent of their calories from saturated fat. From a baseline of 4.5 hours per day of leisure screen time, they decreased screen time by almost three hours and increased their moderate to vigorous exercise by 25 minutes per day over a nine-month trial. Previous research has found that healthy behavior change usually reverts once financial incentives cease. But this study stopped offering the financial incentive after only 12 weeks, and participants still achieved positive results throughout the nine-month trial. The blueberry component pterostilbene has potent anti-myeloma activity  Tongji University (China), June 23, 2022 Investigators at Tongji University School of Medicine Zero  stated, “Multiple myeloma (MM) is an incurable hematologic malignancy because of its drug resistance. Pterostilbene (Pter) is found mainly in blueberries and grapes.” The effects of Pter and its exact pharmacologic mechanisms on chemoresistant myeloma are not known. Herein, we investigated the anti-myeloma activity of Pter in bortezomib-resistant cell line H929R and explored the related mechanism of action for the first time. We found that Pter inhibited proliferation of H929R cells and promoted apoptosis of the cells through a caspase-dependent pathway, loss of mitochondrial membrane potential, and activation of Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways. DNA damage and S-phase arrest might be involved in Pter-related toxicity in H929R cells.  The research concluded: “These data supported that Pter might be a promising natural compound for relapsed/refractory myeloma therapy, especially against myeloma resistant to bortezomib chemotherapy.” Exercise makes the blood of obese people healthier Exercise can reduce inflammation in obese people by changing the characteristics of their blood, according to new research published in The Journal of Physiology. University of Illinois, June 20, 2022 Many of the health problems linked to obesity are a result of chronic inflammation. Inflammation is a natural process in the body in response to harm, but in obese people it can become long term and this can lead to damage of healthy tissue. Certain blood cells are more likely to cause inflammation, and if these cells are made in the body in greater numbers than normal they can spread to organs in the body and cause them to malfunction. The blood cells responsible for causing inflammation are formed from stem cells within the body.  This new research is the first to show that exercise alters the characteristics of these blood forming stem cells and therefore reduces the number of blood cells likely to cause inflammation. These findings provide a new explanation of how exercise may improve health in adults with obesity. Young, lean adults and young, obese adults (who were otherwise healthy) were recruited for this study.  The exercise program consisted of three bicycling or treadmill running sessions per week with each session lasting approximately one hour. Blood was collected before and after the exercise training intervention to quantify blood-forming stem cells. The results of the study demonstrated that exercise reduced the number of blood-forming stem cells associated with the production of the type of blood cells responsible for inflammation. People who go to bed late have less control over OCD symptoms Binghamton University, June 24, 2022 A late bedtime is associated with lower perceived control of obsessive thoughts, according to new research from Binghamton University, State University of New York. Binghamton University Professor Meredith E. Coles monitored twenty individuals diagnosed with OCD and ten individuals endorsing subthreshold OCD symptoms during one week of sleep. Participants completed sleep diaries and daily ratings of perceived degree of control over obsessive thoughts and ritualized behaviors. The researchers found that previous night's bedtime significantly predicted participants' perceived ability to control their obsessive thoughts and compulsive behavior on the subsequent day. “We're really interested in how this kind of unusual timing of sleep might affect cognitive functioning,” said Schubert. “It might be that something about shifting the timing of your sleep might reduce your ability to control your thoughts and your behaviors, so it might make it more likely that you're going to have a hard time dismissing intrusive thoughts characteristic of obsessions, and it might make it more difficult for you to refrain from compulsive behaviors that are designed to reduce the anxiety caused by obsessive thoughts.” On average participants in the study went to bed around 12:30 at night. Patients who met criteria for delayed sleep phase disorder, about 40% of the sample, went to bed around 3 a.m. Green tea-capsaicin-ginger combo linked to weight and metabolic improvements Kashan University of Medical Sciences (Iran), June 24, 2022 Dietary supplements containing green tea, capsaicin and ginger extracts may lead to weight loss and improvements in BMI, says a new study. Data from the randomized double-blind placebo-controlled clinical trial involving 50 overweight women also produced beneficial changes in insulin levels, and measure of insulin resistance. “Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma [glutathione] levels,” wrote the scientists.  Women were assigned to consume daily supplements containing 500 mg green tea, 100 mg capsaicin, and 200 mg ginger extracts, while another 25 women were assigned to consume placebo. After eight weeks, the results showed that, in addition to the improvements in body weight and BMI, women receiving the extracts showed significant decreases in serum insulin concentrations (-2.6 µIU/mL) compared to the placebo (-0.6 µIU/mL). Insulin resistance, as measured by HOMA-IR, also improved compared to placebo, while levels of the antioxidant enzyme glutathione also improved in the women consuming the green tea, capsaicin and ginger supplements (+73.8 µmol/L), while levels decreased in the women receiving placebo (-28.3 µmol/L).

Video: 1. A Rockefeller Document: Resetting The US Food System – Control The Food – Control The People 2. Neil Oliver – ‘we're definitely moving towards a one world government' (3:45) 3.  Exclusive Klaus Schwab Tell All interview! – JP  (11:30) 4. A Rockefeller Document: Resetting The US Food System – Control The Food – Control The People (start @ 0:26 ) 5. New Rule: How the Left Was Lost | Real Time (HBO) HEALTH NEWS Grape consumption may offer benefits for symptomatic knee osteoarthritis Bad habits that lead to cancer, chronic disease corrected by simple lifestyle intervention The blueberry component pterostilbene has potent anti-myeloma activity Exercise makes the blood of obese people healthier People who go to bed late have less control over OCD symptoms Green tea-capsaicin-ginger combo linked to weight and metabolic improvements Grape consumption may offer benefits for symptomatic knee osteoarthritis Texas Woman's University, June 20, 2022 New research suggests that regular grape consumption may help alleviate pain associated with symptomatic osteoarthritis of the knee, and improve joint flexibility and overall mobility. Researchers attribute these potential benefits to the polyphenols found in grapes. The sixteen week clinical study, undertaken by Texas Woman's University, was designed to investigate the benefits of grape consumption on inflammation and osteoarthritis outcomes. 72 men and women with knee osteoarthritis (OA) were assigned to either consume grapes in the form of a whole grape freeze-dried powder, or a placebo powder. The study results showed that both men and women consuming a grape-enriched diet had a significant decrease in self-reported pain related to activity and an overall decrease in total knee symptoms. This beneficial effect was more pronounced in females. Additionally, age-related differences were observed: there was a 70% increase in very hard activity for those under 64 years of age consuming the grape powder, while those receiving the placebo reported a significant decrease in very hard activity. Participants over 65 years, whether consuming grapes or the placebo, reported a decline in moderate to hard activities. Evidence of increased cartilage metabolism was observed in men consuming the grape-enriched diet; they had higher levels of an important cartilage growth factor (IGF-1) than those on placebo. This protective effect was not observed in the females. T Bad habits that lead to cancer, chronic disease corrected by simple lifestyle intervention Northwestern University, June 19, 20122 Does this sound like someone you know? He or she spends too much time in front of screens, gets little exercise and eats a diet high in fat and low in fruits and vegetables. It likely sounds familiar because it describes a significant portion of the U.S. population. A new Northwestern Medicine study found that a lifestyle intervention could fully normalize these four unhealthy behaviors, which put people at risk of developing heart disease and common cancers, including breast, colon and prostate. “Our findings suggest that prevention of chronic disease through behavior change is feasible. They contradict the pessimistic assumption that it's not possible to motivate relatively healthy people to make large, long-lasting healthy lifestyle changes,” said lead author Bonnie Spring at Northwestern University Feinberg School of Medicine. With the help of a smartphone app, a wearable activity tracker, some social support from a coach and a small financial incentive, study participants made large improvements in their eating and activity habits. From a starting point of less than two servings of fruits and vegetables per day, they increased their intake by 6.5 servings per day. They decreased saturated fat intake by 3.6 percent to consume less than 8 percent of their calories from saturated fat. From a baseline of 4.5 hours per day of leisure screen time, they decreased screen time by almost three hours and increased their moderate to vigorous exercise by 25 minutes per day over a nine-month trial. Previous research has found that healthy behavior change usually reverts once financial incentives cease. But this study stopped offering the financial incentive after only 12 weeks, and participants still achieved positive results throughout the nine-month trial. The blueberry component pterostilbene has potent anti-myeloma activity  Tongji University (China), June 23, 2022 Investigators at Tongji University School of Medicine Zero  stated, “Multiple myeloma (MM) is an incurable hematologic malignancy because of its drug resistance. Pterostilbene (Pter) is found mainly in blueberries and grapes.” The effects of Pter and its exact pharmacologic mechanisms on chemoresistant myeloma are not known. Herein, we investigated the anti-myeloma activity of Pter in bortezomib-resistant cell line H929R and explored the related mechanism of action for the first time. We found that Pter inhibited proliferation of H929R cells and promoted apoptosis of the cells through a caspase-dependent pathway, loss of mitochondrial membrane potential, and activation of Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways. DNA damage and S-phase arrest might be involved in Pter-related toxicity in H929R cells.  The research concluded: “These data supported that Pter might be a promising natural compound for relapsed/refractory myeloma therapy, especially against myeloma resistant to bortezomib chemotherapy.” Exercise makes the blood of obese people healthier Exercise can reduce inflammation in obese people by changing the characteristics of their blood, according to new research published in The Journal of Physiology. University of Illinois, June 20, 2022 Many of the health problems linked to obesity are a result of chronic inflammation. Inflammation is a natural process in the body in response to harm, but in obese people it can become long term and this can lead to damage of healthy tissue. Certain blood cells are more likely to cause inflammation, and if these cells are made in the body in greater numbers than normal they can spread to organs in the body and cause them to malfunction. The blood cells responsible for causing inflammation are formed from stem cells within the body.  This new research is the first to show that exercise alters the characteristics of these blood forming stem cells and therefore reduces the number of blood cells likely to cause inflammation. These findings provide a new explanation of how exercise may improve health in adults with obesity. Young, lean adults and young, obese adults (who were otherwise healthy) were recruited for this study.  The exercise program consisted of three bicycling or treadmill running sessions per week with each session lasting approximately one hour. Blood was collected before and after the exercise training intervention to quantify blood-forming stem cells. The results of the study demonstrated that exercise reduced the number of blood-forming stem cells associated with the production of the type of blood cells responsible for inflammation. People who go to bed late have less control over OCD symptoms Binghamton University, June 24, 2022 A late bedtime is associated with lower perceived control of obsessive thoughts, according to new research from Binghamton University, State University of New York. Binghamton University Professor Meredith E. Coles monitored twenty individuals diagnosed with OCD and ten individuals endorsing subthreshold OCD symptoms during one week of sleep. Participants completed sleep diaries and daily ratings of perceived degree of control over obsessive thoughts and ritualized behaviors. The researchers found that previous night's bedtime significantly predicted participants' perceived ability to control their obsessive thoughts and compulsive behavior on the subsequent day. “We're really interested in how this kind of unusual timing of sleep might affect cognitive functioning,” said Schubert. “It might be that something about shifting the timing of your sleep might reduce your ability to control your thoughts and your behaviors, so it might make it more likely that you're going to have a hard time dismissing intrusive thoughts characteristic of obsessions, and it might make it more difficult for you to refrain from compulsive behaviors that are designed to reduce the anxiety caused by obsessive thoughts.” On average participants in the study went to bed around 12:30 at night. Patients who met criteria for delayed sleep phase disorder, about 40% of the sample, went to bed around 3 a.m. Green tea-capsaicin-ginger combo linked to weight and metabolic improvements Kashan University of Medical Sciences (Iran), June 24, 2022 Dietary supplements containing green tea, capsaicin and ginger extracts may lead to weight loss and improvements in BMI, says a new study. Data from the randomized double-blind placebo-controlled clinical trial involving 50 overweight women also produced beneficial changes in insulin levels, and measure of insulin resistance. “Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma [glutathione] levels,” wrote the scientists.  Women were assigned to consume daily supplements containing 500 mg green tea, 100 mg capsaicin, and 200 mg ginger extracts, while another 25 women were assigned to consume placebo. After eight weeks, the results showed that, in addition to the improvements in body weight and BMI, women receiving the extracts showed significant decreases in serum insulin concentrations (-2.6 µIU/mL) compared to the placebo (-0.6 µIU/mL). Insulin resistance, as measured by HOMA-IR, also improved compared to placebo, while levels of the antioxidant enzyme glutathione also improved in the women consuming the green tea, capsaicin and ginger supplements (+73.8 µmol/L), while levels decreased in the women receiving placebo (-28.3 µmol/L).

Insulin resistance is at the root cause of almost every lifestyle disease. It only makes sense to live a low-insulin lifestyle in order to reverse it. Dr. Alexandra Sowa is passionate about helping her patients reverse insulin resistance, and having a way to test for it at their fingertips. In this podcast episode, we discuss: Dr. Sowa's personal story and growing interest in insulin resistance What insulin resistance is, and why she developed home testing for it Why your doctor may not want to test for insulin resistance What is included in testing kits and how to interpret How to find your HOMA-IR score and start reversing insulin resistance Testing for Type 1 and Type 2 diabetes How to use berberine as a supplement to reduce blood sugar levels Learn more about Dr. Alexandra Sowa: Website: https://alexandrasowamd.com/ IG: @alexandrasowamd Get So Well: https://www.getsowell.com/ IG: @getsowell Get 10% off your testing kit HERE by using the code SHANA10! Follow me on: Instagram: @shana.hussin.rdn Facebook: Fast To Heal With Shana Hussin Website: https://www.fasttoheal.info/ ADDITIONAL LINKS: ENROLL IN FAST TRACK, my new monthly membership program for accountability. GRAB YOUR COPY of the Fast To Heal Recipe book with 85 low-carb, whole food recipes that are simple to prepare! GET YOUR FREE STARTING GUIDES that will set you well on your way toward a low-carb lifestyle of timed eating! SCHEDULE A PERSONALIZED SESSION if you are stuck in a rut, or suffer from a stubborn case of obesity, Type 2 diabetes, or metabolic illness. JUMPSTART your fasting and low-carb protocol by enrolling in my 10-Day Hormone Healing Jumpstart! ENROLL in Finding Nutritional PEACE, my highest level online self-paced course to reverse insulin resistance and chronic illness WATCH MY FREE MASTERCLASS to learn all about the methods I teach and how to start reversing your stubborn weight and health issues TODAY!

TODAY'S SPONSOR:SoWell, the at-home Fasting Insulin Test! Why Insulin? When you go to the doctor they test glucose and HbA1C, but not INSULIN! Over 50% of the population suffers from Insulin Resistance and it is at the root of diabetes, and many other chronic diseases. Even if you ask your doctor for a fasting insulin test, they often REFUSE! If you get it, your doctor might say that anything below 23 is "fine" but ideally, you may not feel well unless it's somewhere between 2-5. SoWell's at-home fasting insulin test also tests: fasting glucose, HbA1C, Thyroid Stimulating Hormone, Vitamin B12, HDL Cholesterol, LDL Cholesterol and Triglycerides!Use the code DANI10 to save 10% on this incredibly informative test!____________________TODAY'S GUEST:"Traditional medicine only allows time and room for medication management. There's no time for lifestyle and nutrition management." Dr. Alexandra Sowa is a duel board-certified physician of internal medicine, specializing in metabolic health, and clinical instructor of medicine at NYU Langone. Dr. Sowa has served as a health expert for national media outlets and print publications like SiriusXM, CBS News, NPR, the New York Times, U.S. News, World Report, and more. In addition to her private practice in NYC, she is the founder of SoWell Health, a consumer metabolic health company. SoWell Health's foundational product, The Weight Biology Kit, is the first at-home lab kit to test for insulin resistance and other metabolic factors that make up your weight biology. You can learn more about Dr. Sowa and SoWell at getsowell.com.On today's episode we talk all about: Dr. Sowa's disillusion with mainstream medicineWhy nutrition needs to be the core of any health and weight loss planThe number 1 marker that tells you how to create a personalized health plan and how to uncover and get to the root causes of diseaseThe problems with the mainstream medical system according to a doctorThe outdated dogma Dr. Sowa was taughtDoctors don't get education on how to interpret fasting insulin testingWhy is fasting insulin so importantWhat is Insulin Resistance and where we got it wrong in traditional medicineWhat are the ramifications of Insulin ResistanceBy the time your A1C is high or by the time the blood sugar is high, insulin has been creeping up for 20 yearsPCOS is a disease of Insulin Resistance Benefits of metformin on insulin sensitivityTraditional ranges of Insulin vs Functional (Ideal) Ranges of InsulinWhat the HOMA/IR score is and why it's so importantStrategies to improve Insulin SensitivityThe alarming amount of people who have Insulin Resistance____________________Thank you for listening to the show!You can find me on Instagram @daniellehamiltonhealth and on Facebook at Danielle Hamilton Health.My website is daniellehamiltonhealth.com. Be sure to sign up for my *brand new* weekly newsletter to get all the best tips, coupon codes, and to be the first to know about my upcoming programs!If you are liking the show, please head to Apple Podcasts or iTunes to leave the show a *5-star rating* & a quick review! It helps the show to grow and lets me know what you're liking!Thank you for subscribing, rating, reviewing, sharing and reposting the show! I appreciate each and every one of you!

Did you know that belly fat, weight gain, low energy, carb and sugar cravings, high blood sugar, high triglycerides, and high blood pressure are all underlying signs of insulin resistance?Watch this interview with Dr. Alexandra Sowa, founder of SoWell Health to learn why lowering insulin resistance is the key to unlock better health. When you lower insulin resistance, not only will weight loss become easier, but you'll also be improving your overall health profile and reducing your risk of diabetes, heart disease, and dementia.To find a doctor specialized in Obesity Medicine - American Board of Obesity Medicine: https://www.abom.org/ Here's what we cover in this episode:Normal and high fasting insulin scores. How elevated insulin elevates decades before glucose. What is a good HOMA-IR score and how to calculate it?Dr. Sowa's response when her clients come to her saying, "My doctor said I'm fine and to eat less and exercise more."How to get the Weight Biology Test so you can test your metabolic health at home including: fasting glucose, insulin, A1c, triglycerides, HDL, LDL, Thyroid Stimulating Hormone, and vitamin B12.CoachingIf you're ready to lose the weight for good, you've come to the right place!Join our online course and coaching program Zivli, to learn the science behind weight loss and habit change so you can lose weight, get healthy, and prevent disease.To learn more, go to https://www.zivli.com/join.Free Weight Loss ResourcesWeight Loss Masterclass to Lower Insulin Resistance & InflammationHow to Actually Reach Your Goals | Free Weight Loss Mindset TrainingThe Ultimate Food Guide | What to Eat to Burn FatConnect on Social>> Subscribe to My YouTube Channel>> Like My Facebook Page>> Follow Me on Instagram>> Connect on LinkedIn>> View My WebsiteConnect with Dr. Alexandra Sowa>> Follow on Instagram>> View Her Website Subscribe & Review in Apple PodcastsAre you subscribed to my podcast? If you're not, I want to encourage you to do that today. I don't want you to miss an episode. Click here to subscribe in Apple Podcasts.Now if you're feeling extra loving, I would be really grateful if you left me a review over on Apple Podcasts, too. Those reviews help other people find my podcast and they're also fun for me to go in and read. Just click here to review, select “Ratings and Reviews” and “Write a Review” and let me know what your favorite part of the podcast is. Thank you!

Today, I am thrilled and honored to be talking to Dr. Alexandra Sowa. Dr. Sowa is a dual board-certified physician of internal medicine, specializing in metabolic health, and clinical instructor of medicine at NYU Langone. She has served as a health expert for national media outlets and print publications like SiriusXM, CBS News, NPR, the New York Times, U.S. News, World Report, and more. In addition to her private practice in NYC, she is the founder of SoWell Health, a consumer metabolic health company.  Over the years, people kept complaining to Dr. Sowa about weight gain, decreased endurance, brain fog, and irregular periods, even when their doctors had told them they were healthy and their labs looked fine. When Dr. Sowa checked their labs, however, she would immediately see that they had metabolic syndrome, an underactive thyroid, a vitamin deficiency, and in 90% of the cases, insulin resistance too. During the turbulent period of the pandemic, Dr. Sowa finally had the time to sit and think about how she could help those patients. She came up with a unique solution and developed a home-testing kit to assess and address the symptoms of people's metabolic health issues. In this episode, we discuss the scope of metabolic health in the U.S., and Dr. Sowa explains how she came up with her Weight Biology Kit. We talk about the importance of making the right nutritional choices and improving your health by making better lifestyle decisions. We dive into the role of using technology to monitor health, the influence of alcohol, and using Naltrexone to overcome alcohol cravings. We also unpack the notions of cheat days and biohacking in the wellness space. Remember to check out Dr. Sowa's Weight Biology Kit, a point-of-care testing kit for insulin resistance. Stay tuned for more!  IN THIS EPISODE YOU WILL LEARN: How Dr. Sowa came up with her home-testing kit to address people's metabolic issues. Insulin is often the first biomarker to become dysregulated as people move towards insulin resistance. Dr. Sowa explains why insulin is a better predictor than blood sugar of where people are in terms of their metabolic health. Why do people with high insulin levels gain weight even if they are calorie-restricting and eating very little? How does nutrition impact metabolic health? The two most important things you can do to improve your health if you have elevated insulin, and you show signs of insulin resistance. Three lifestyle changes that, in addition to better nutrition, can be instrumental in helping improve fasting insulin and blood sugar levels. The disruptive role alcohol can play in your metabolic health. Some tips for overcoming alcohol cravings. Why is it best to avoid having cheat days? The benefits of journaling, as a motivator for changing behavior. The roles technology and biohacking can play in metabolic health. The eight areas that get tested in Dr. Sowa's core point-of-care home testing products. Dr. Sowa explains what the HOMA-IR score is. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia's website  Connect with Dr. Alexandra Sowa On her website On Instagram (@getsowell) On Instagram (@alexandrasowamd)

CoQ10 may help blood sugar management in people with MetS Kashan University of Medical Sciences (Iran), December 5, 2021 Daily supplements of coenzyme Q10 may produce beneficial effects on insulin and blood sugar management in people with metabolic syndrome, says a new study. Writing in the PubMed-listed European Journal of Nutrition , researchers from Kashan University of Medical Sciences in Iran report that CoQ10 supplementation was also associated with significant improvements in serum insulin levels, insulin resistance (measured using the homeostatic model assessment: HOMA-IR), and beta-cell function (homeostatic model assessment-beta cell function: HOMA-B). Results showed that participants in the CoQ10 group experienced significant improvements in insulin levels, HOMA-IR, and HOMA-B, while there was also a trend to improved levels of glutathione and reduced levels of malondialdehyde, a reactive carbonyl compound that is a marker of oxidative stress. (NEXT) Eucalyptus compound effective at treating lung damage  University of Melbourne & Monash University (Australia), December 4, 2021 University of Melbourne-led research has shown the flavonoid pinocembrin, derived from Australian eucalyptus trees, has strong anti-inflammatory properties and could be safe and effective at treating lung fibrosis in sheep, a large animal model for human lung disease. Pinocembrin, a flavonoid found in several different type of trees including pine trees and eucalyptus, has been reported to have antioxidant, anti-inflammatory, anti-microbial and anti-cancer properties. "We found that pinocembrin improved lung function, attenuated lung inflammation, and decreased overall pathology scores compared to damaged lungs that were untreated," Dr. Derseh said. "We saw striking anti-inflammatory effects and modest anti-fibrotic remodeling after four weeks of administering pinocembrin." "In lung fluid samples, inflammatory cells called neutrophils dropped from 7.4 percent of total cells to 3.7 percent in the pinocembrin-treated bleomycin-injured lung segments." (NEXT) Study links high cholesterol, cardiovascular disease to plastics University of California at Riverside, December 2, 2021 Plastics, part of modern life, are useful but can pose a significant challenge to the environment and may also constitute a health concern. Indeed, exposure to plastic-associated chemicals, such as base chemical bisphenol A and phthalate plasticizers, can increase the risk of human cardiovascular disease. What underlying mechanisms cause this, however, remain elusive. A team led by Changcheng Zhou, a biomedical scientist at the University of California, Riverside, now raises the hopes of solving the mystery. In a mouse study, the researchers found a phthalate—a chemical used to make plastics more durable—led to increased plasma cholesterol levels. (NEXT) Environmentally sustainable diet linked to health benefits Lund University (Sweden), December 9, 2021 A large population study from Lund University in Sweden has shown that more sustainable dietary habits are linked to health benefits, such as a reduced risk of premature death from cardiovascular disease and cancer. The study is published in The American Journal of Clinical Nutrition. "Our results indicate that dietary guidelines that are beneficial for both planetary health and personal health do exist," says Anna Stubbendorff, doctoral student at Lund University and first author of the study. The EAT-Lancet Commission report describes how the world must transform its food production and consumption if the Earth's already fragile environment and scarce resources are to suffice for 10 billion people in 2050. The report covered six different areas: climate impact, water use, biodiversity, phosphorus and nitrogen use and acidification. (NEXT) Move Over, Wheat! Rye Bread Is Better for Weight Loss Chalmers University (Sweden), December 2, 2021 New research from Chalmers University in Sweden found that dieters who consumed whole-grain rye lost more weight than those who went for refined wheat. In the 12-week-long study, 242 overweight or obese participants were randomly selected to eat either high fiber rye products or refined wheat products in addition to a hypocaloric diet. Those in the rye group lost an average of 6.4 lbs. and more body fat compared to those in the wheat group, who only lost 4 lbs. "Why rye?" On average, a slice of rye bread is relatively low in calories (around 83 calories) and packed with beneficial nutrients like, folate, iron, copper, niacin and vitamin B6. (NEXT) Vitamins C and E associated with decreased inflammation in diabetics Ahvaz Jundishapur University of Medical Sciences (Iran), December 30 2015. The Avicenna Journal of Phytomedicine published the finding of a trial conducted by Iranian researchers of anti-inflammatory effects of vitamin C and vitamin E in male diabetics. It is possible to control insulin resistance and diabetes by modulating inflammatory cytokines and adipokines using chemical drugs or supplementary micronutrients. (NEXT) What's really wrong with the mainstream media Robert Reich,   The Guardian, December 9, 2021 I'm often asked how I keep up with the news. Obviously, I avoid the unhinged rightwing outlets pushing misinformation, disinformation and poisonous lies. But I've also grown wary of the mainstream media – not because it peddles “fake news” but because of three more subtle biases. First, it often favors the status quo. Mainstream journalists wanting to appear serious about public policy rip into progressives for the costs of their proposals, but never ask self-styled “moderates” how they plan to cope with the costs of doing nothing or doing too little about the same problems. A Green New Deal might be expensive but doing nothing about the climate crisis will almost certainly cost far more. Medicare for All will cost a lot, but the price of doing nothing about America's cruel and dysfunctional healthcare system will soon be in the stratosphere. (NEXT) A massive 8-year effort finds that much cancer research can't be replicated SCIENCE NEWS, DECEMBER 7, 2021  After eight years, a project that tried to reproduce the results of key cancer biology studies has finally concluded. And its findings suggest that like research in the social sciences, cancer research has a replication problem. Researchers with the Reproducibility Project: Cancer Biology aimed to replicate 193 experiments from 53 top cancer papers published from 2010 to 2012. But only a quarter of those experiments were able to be reproduced, the team reports in two papers published December 7 in eLife. The researchers couldn't complete the majority of experiments because the team couldn't gather enough information from the original papers or their authors about methods used, or obtain the necessary materials needed to attempt replication. What's more, of the 50 experiments from 23 papers that were reproduced, effect sizes were, on average, 85 percent lower than those reported in the original experiments. Effect sizes indicate how big the effect found in a study is. For example, two studies might find that a certain chemical kills cancer cells, but the chemical kills 30 percent of cells in one experiment and 80 percent of cells in a different experiment. The first experiment has less than half the effect size seen in the second one. (NEXT) Bayer executive: mRNA shots are ‘gene therapy' marketed as ‘vaccines' to gain public trust ‘We probably would have had a 95% refusal rate' for these shots two years ago, but the pandemic and marketing of the injections as ‘vaccines' has made them popular with the public, said Stefan Oelrich. LIFESITE, Wed Nov 10, 2021 The president of Bayer's Pharmaceuticals Division told international “experts” during a globalist health conference that the mRNA COVID-19 shots are indeed “cell and gene therapy” marketed as “vaccines” to be palatable to the public. Stefan Oelrich, president of Bayer's Pharmaceuticals Division, made these comments at this year's World Health Summit, which took place in Berlin from October 24-26 and hosted 6,000 people from 120 countries. Oelrich told his fellow international “experts” from academia, politics, and the private sector that the novel mRNA COVID “vaccines” are actually “cell and gene therapy” that would have otherwise been rejected by the public if not for a “pandemic” and favorable marketing. (NEXT) VAERS Data Indicates the Covid Vaccines Have Killed At Least 140,000 Americans Vasko Kohlmayer.  American Thinker, December 9, 2021 To get an idea of just how dangerous the current Covid vaccines are, we only need to look at the numbers in the government-authorized VAERS database. If we, then, adjust our VEARS number for this variable, we will obtain the result of 140,616 (3,906 x 36). This would represent the number of Americans killed by the Covid vaccines in a period of fewer than 12 months starting in mid-December 2020 through November 26, 2021. Please keep in mind that the above is a very conservative estimate, which we have arrived at by assuming a 20 percent causality link in reported death entries in the VAERS database and the underreporting factor of 36. This, however, is likely a gross understatement of the actual situation. Using less conservative assumptions, many researchers have come up with a higher death toll. Steve Kirsch, Jessica Rose, and Mathew Crawford, for example, estimated in their paper that the vaccines have likely claimed 150,000 lives as of August 28, 2021. If we use the underreporting factor of 100 (one hundred) advocated by David A. Kessler, Ronald Kostoff, and the Department of Health and Human Services we would arrive at the figure of 390,600 deaths attributable to the vaccines. (NEXT) Vaccine Acquired Immune Deficiency Syndrome (VAIDS): 'We should anticipate seeing this immune erosion more widely' FRONTLINE NEWS, Dec 05, 2021 'If immune erosion occurs after two doses and just a few months, how can we exclude the possibility that effects of an untested "booster" will not erode more rapidly and to a greater extent?' A Lancet study comparing vaccinated and unvaccinated people in Sweden was conducted among 1.6 million individuals over nine months. It showed that protection against symptomatic COVID-19 declined with time, such that by six months, some of the more vulnerable vaccinated groups were at greater risk than their unvaccinated peers. Doctors are calling this phenomena in the repeatedly vaccinated “immune erosion” or “acquired immune deficiency”, accounting for elevated incidence of myocarditis and other post-vaccine illnesses that either affect them more rapidly, resulting in death, or more slowly, resulting in chronic illness. First, these vaccines “mis-train” the immune system to recognize only a small part of the virus (the spike protein). Variants that differ, even slightly, in this protein are able to escape the narrow spectrum of antibodies created by the vaccines. Second, the vaccines create “vaccine addicts,” meaning persons become dependent upon regular booster shots, because they have been “vaccinated” only against a tiny portion of a mutating virus. Australian Health Minister Dr. Kerry Chant has stated that COVID will be with us forever and people will “have to get used to” taking endless vaccines. “This will be a regular cycle of vaccination and revaccination.” Third, the vaccines do not prevent infection in the nose and upper airways, and vaccinated individuals have been shown to have much higher viral loads in these regions. This leads to the vaccinated becoming “super-spreaders” as they carry extremely high viral loads. In addition, the vaccinated become more clinically ill than the unvaccinated. Scotland reported that the infection fatality rate in the vaccinated is 3.3 times the unvaccinated, and the risk of death if hospitalized is 2.15 times the unvaccinated. Indefinite uncontrolled autoimmune response to the coronavirus spike protein may produce a wave of antibodies called anti-idiotype antibodies or Ab2s that continue to damage human bodies long after clearing either Sars-Cov-2 itself or those spike proteins that the shots cause the body's cells to produce, explained former New York Times reporter Alex Berenson. Spike protein antibodies may themselves produce a second wave of antibodies, called anti-idiotype antibodies or Ab2s. Those Ab2s may modulate the immune system's initial response by binding with and destroying the first wave of antibodies. “While some are concerned that blood IgG antibodies fall with time, I am not convinced that this is a relevant measure,” Yeadon continued. "Respiratory virus infection begins in the lungs and nasopharynx. Neither are protected by blood antibodies, which are molecules too large to diffuse into airways tissue. What protects against infection and initial viral replication is secretory IgA antibodies and T-cells in airways, neither of which have been studied in any efficacy trial. "The empirical data are very worrying. In most countries now, high fractions of the population have been vaccinated. If the Swedish study is a guide, we should anticipate seeing this immune erosion more widely. The most concerning aspect of that study is that those most in need of protection are those in whom immune erosion is most marked: the elderly, males, and those with comorbidities. "Some have used the results of this study to support the widespread use of so-called ‘booster' shots. It has to be said: No one has any safety data about such a plan. If immune erosion occurs after two doses and just a few months, how can we exclude the possibility that effects of an untested ‘booster' will not erode more rapidly and to a greater extent? And what then would be the response? A fourth injection. Madness. Yeadon concluded: "Europe is all but gone. The lights are going out. Austria and Germany now subject their unvaccinated to house arrest. In Greece, the unvaccinated are subject to escalating fines, non-payment of which is converted into prison time. In Lithuania, the unvaccinated are excluded from society. The booster campaigns are running full-pelt everywhere. “Someone, somewhere knows what's going to happen. Will immunity-erosion worsen more speedily and to a greater extent after this untested ‘booster'? The U.K. government has already said that the fourth injection is to take place a mere three months after the third. It's utter madness. Yet such is the hermetic control of media that nothing much emerges into the public consciousness.”

It's important to know how to test for insulin resistance. Check this out! HOMA-IR ➜ ➜ https://youtu.be/Fr7RkcHGxtk FREE COURSE ➜ ➜ https://courses.drberg.com/product/how-to-bulletproof-your-immune-system/ FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! ADD YOUR SUCCESS STORY HERE: https://bit.ly/3z9TviS Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

Watch to learn what is insulin resistance and why does it occur. This presentation covers what is insulin resistance, the link between insulin resistance and obesity, insulin resistance causes, insulin resistance symptoms, insulin resistance testing, insulin resistance diet, insulin resistance and intermittent fasting, insulin resistance treatment, including the best insulin resistance diet and intermittent fasting to reverse insulin resistance. Learn evidence-based information to reverse obesity and type 2 diabetes. See the below time stamps to find the information you're looking for quickly: How is obesity measured? - 5:15Maps of increasing obesity in America 1990 through 2019 - 7:29Why the rise in obesity and severe obesity since 1977? - 10:10Health conditions associated with obesity - 14:46The financial costs associated with obesity - 16:08What causes obesity...insulin or calories? - 17:31Brain insulin sensitivity - 20:40Visceral vs subcutaneous body fat - 24:00 Hypothalamus and hunger regulation - 27:12 Ghrelin hormone function - 28:25Satiety hormones - 31:31Body set point weight (working and not working)- 32:39Weight regain after weight loss explained - 38:44 How long your metabolism stays lower after weight loss - 42:56Best diet for long-term weight loss - 44:56Insulin and weight gain - 55:46What is insulin resistance? - 59:53Insulin resistance testing (fasting insulin and HOMA-IR tutorial) - 1:01:29Signs and symptoms of insulin resistance - 1:02:54The “Yellow Brick Road” of insulin resistance - 1:06:38What causes insulin resistance? - 1:08:43Adipocyte hypertrophy vs hyperplasia - 1:11:11Brief review of U.S. nutrition recommendations 1940 through now - 1:17:09Why tracking macronutrients is helpful for weight loss - 1:20:08How is insulin affected by different macronutrients? - 1:21:39Different types of carbohydrates explained - 1:22:27Why protein is important and good for weight loss - 1:22:48Diet induced thermogenesis explained - 1:30:52Which fats are good for you? (saturated vs unsaturated fat) - 1:33:20Omega-3 fatty acids (plant vs animal-based) - 1:37:05Are saturated fats good for you? - 1:38:37Saturated fats, cholesterol, and heart disease - 1:41:58Sugar and heart disease - 1:43:25Insulin resistance diet (eat lots of these!) - 1:46:11Insulin resistance diet (avoid or eat these less than daily) - 1:50:51Intermittent fasting and insulin resistance - 1:54:15Sleep and insulin resistance - 1:58:12Best exercise for insulin resistance - 1:59:13Mindset for losing weight - 2:05:42CoachingIf you're ready to lose the weight for good, you've come to the right place!Join my online course, Weight Loss for Health, to learn the science behind weight loss and habit change so you can lose weight, get healthy, and prevent disease. To learn more, go to https://www.weightlossforhealth.com/join.Connect on Social>> Subscribe to My YouTube Channel>> Like My Facebook Page>> Follow Me on Instagram>> Connect on LinkedIn>> View My Website

Welcome to another episode of the Fertility Confidence podcast. I am your host, Dr. Kelsey Duncan, naturopathic doctor, and the founder and creator of the Fertility Confidence method.  In today's episode, we are delving deeper into our discussion on Insulin, the overlooked and under-discussed hormone that does, in fact, have an impact on our fertility.  This is part two of this conversation focusing strongly on Insulin resistance, what we can do post-testing, and laying the foundations with our three most powerful tools - nutrition, movement, and sleep. I do want to preface this episode by stating that we are talking in general terms today, that it is important for you to talk to your healthcare provider first before starting any supplements or changes in your health routine. This episode will support you in taking some of these questions or info back to your practitioner that you are working with, or if you want to work with my team to help you understand, please reach out to us via the contact information shared in these show notes. Here are the main topics of today's episode: Refresh of Part One Lay the foundations Nutrition Movement Sleep and the hormone, Leptin Supplements and Vitamin D testing My sincerest thanks for pressing play today. Join our growing community of strong, hopeful women, each on their own fertility confidence journey; as well as those that are listening to gain the knowledge and understanding needed to support them via the Fertility Confidence Instagram @fertilityconfidencemethod or through our Facebook group Be Hormonally Confident with Dr.Kelsey.  If you could do me the honor of hitting the subscribe button, leaving a review, and sharing the podcast with a friend that needs to hear these conversations, I would be forever grateful. Curious about how you can work with me and my team? Book your free clarity call here.  Quotes “With insulin, nutrition, and movement, or our two most powerful tools.” “ To keep your hormones balanced you want lean proteins, healthy, fat, complex carbs” “Make sure you're actually having adequate portion sizes to reach your caloric requirements because too few calories will actually do more harm than good.” “ If you're having a fruit, or if you having a carb, pair it with a fat or protein to actually help your body digest that sugar more effectively. So we'll have less of those glucose-insulin spikes.” “ A study in 2014 found that women who spent three hours per week walking had a significant visceral and subcutaneous fat loss, as well as a significant reduction in fasting glucose HOMA IR. …so they lost weight, improved their blood pressure and their insulin resistance” “I found numerous studies done, more done in men than in women, but the consensus being that less than six hours of sleep per night greatly increased the risk of diabetes and insulin resistance. And the treatment of getting more sleep actually helped to improve insulin resistance.” “So if you have the nutrition, if you have the movement nailed down and you are sleeping consistently and well each and every night, Then we can talk about supplements, but I really want you to work on these foundational pieces first” “I really do hope people will start getting Vitamin D testing once a year at minimum, if not twice a year, I typically recommend testing twice a year in spring and right before winter” “To recap, you are going to eat whole foods, establish a nutrition plan with lots of lean protein, healthy fat veggies, complex carbs, some fruit, and a little bit of dairy. You are going to walk for a total of three or more hours every single week, you are going to prioritize your sleep because not getting enough sleep is not doing you any good in a wide variety of ways, but definitely, with your insulin resistance and your hormones, you're then going to talk to your healthcare provider and figure out if and what supplements may be right for you or your body and you're going to have your vitamin D tested”  

 Cardiovascular exercise (CV), and other such classifications of fitness endeavors, has extensive research to support the American College of Sports Medicine’s broad definition as “exercise medicine.” Current, established activity guidelines include recommending a minimum of 150 minutes of moderate-intensity exercise, or 75 minutes of high-intensity weekly exercise to maintain or improve cardiorespiratory fitness and health, while reducing the risk to non-communicable diseases – type 2 diabetes, cancer, osteoporosis, stroke, and more.The nomenclature of CV exercise has specific variations, such as endurance exercise, in the form of moderate-intensity, continuous training (MICT), and high-intensity interval exercise (HIIE) - referenced as high-intensity interval training (HIIT), and sprint interval training (SIT). HIIT involves alternating intervals at greater than 80% of maximum endurance capacity (VO2 Max) or 85% of your maximal heart rate (220-age), typically 1 to 4 minutes in duration – with lower intensity, active or passive recovery, while SIT uses short – full go – intervals, typically less than 30 seconds, with short, passive recovery.Writing in the March 2021 issue of Medicine & Science in Sports & Exercise – Effectiveness of HIIE versus MICT in Improving Cardiometabolic Risk Factors in Health and Disease: a Meta-Analysis - researchers from the Sports Medicine Department, Clinical Epidemiology and Applied Biometrics Department, and the Psychosomatic Medicine and Psychotherapy Department, University Hospital of Tubingen in Germany, used a meta-analysis (many similar studies) to investigate the clinical benefits distinguishing each exercise modality (HIIE and MICT) in health and disease. The data search began in January of 2018 and culminated in July of 2020.The seven key clinical endpoints of the literature analysis included: “physical fitness (VO2 max), endothelial function (flow-mediated dilation [FMD]), body composition (body mass index [BMI], body mass, and body fat), blood pressure (systolic and diastolic blood pressure), blood lipids (HDL, LDL, triglycerides, and total cholesterol), inflammation (C-reactive protein [CRP]), and insulin and glucose metabolism (fasting glucose, fasting insulin, glycated hemoglobin [HbA1c], and insulin resistance (HOMA-IR).”After a comprehensive analysis of the data, the researchers said, “overall, HIIE showed to be more effective in improving cardiovascular health and cardio- respiratory fitness, whereas MICT was superior in improving long-term glucose metabolism.”From an aging perspective, the data analysis determined that relative to endothelial function, which protects tissues from toxic substances, regulates the blood clotting mechanism, controls the transition of fluid and certain substances between the blood and tissues, and inflammatory control in tissues - it was determined that the HIIE had higher effects than did the MICT – the result of the “interval-like” exercise training programs inducing a, “higher shear stress, and promoting an increased nitric oxide release.” The Germans recommended that, “in the process of personalized training counseling, health-enhancing effects of exercise training may be improved by considering the individual risk profiles.”And, that risk stratification needs to start with your personal physician. For more information on this topic and more, go to maxwellnutrition.com.

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy. George Orwell and 1984: How Freedom Dies Orwell's final warning - Picture of the future The Efficacy of Olive Leaf Extract on Healing Herpes Simplex Virus: A Randomized Double-blind Study Lorestan University of Medical Sciences (Iran), January 29, 2021   Herpes simplex virus (HSV), as a common infection in healthy individuals, is treated symptomatically, but drug resistance and the side effects of drugs have drawn the attention of researchers to complementary medicine. Olive Leaf Extract (OLE) has antiviral effects that may treat HSV. The current study aimed to compare the clinical effects of OLE and Acyclovir on HSV-1. Methods This randomized double-blind clinical trial was conducted on 66 patients who had already been diagnosed with HSV-1. The participants were randomized into two groups, receiving 2% OLE cream or 5% acyclovir cream five times a day for six days. The symptoms were evaluated before, and three and six days after the interventions. Data were analyzed using the SPSS software through the Kolmogorov-Smirnov test, chi-squared, t-test, and repeated measures ANOVA. Results The results showed clinical symptoms decreased in both groups during the study and both medications were effective in the treatment of HSV-1. However, the OLE group experienced less bleeding (P=0.038), itching (P=0.002), and pain (P=0.001) on the third day as well as less irritation (P=0.012), itching (P=0.003) and color change (P=0.001) on the sixth day compared to the acyclovir group. The treatment course for participants in the OLE group was shorter than in the acyclovir group (P = 0.001). Conclusion The evidence from these trials suggests the OLE cream is superior in the healing of episodes of HSV-1 over the acyclovir cream. Future studies are recommended to investigate if OLE could be an adjunct to acyclovir treatment.   How vitamins, steroids and potential antivirals might affect SARS-CoV-2 Study indicates that some vitamins, steroids and antivirals could bind to the Spike protein, and may inhibit virus infectivity, whereas high cholesterol may enable the virus University of Bristol (UK), January 29, 2021   Evidence is emerging that vitamin D - and possibly vitamins K and A - might help combat COVID-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they - and other antiviral drugs - might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so might reduce SARS-CoV-2 infectivity. In contrast, cholesterol may increase infectivity, which could explain why having high cholesterol is considered a risk factor for serious disease. Recently, Bristol researchers showed that linoleic acid binds to a specific site in the viral spike protein, and that by doing so, it locks the spike into a closed, less infective form. Now, a research team has used computational methods to search for other compounds that might have the same effect, as potential treatments. They hope to prevent human cells becoming infected by preventing the viral spike protein from opening enough to interact with a human protein (ACE2). New anti-viral drugs can take years to design, develop and test, so the researchers looked through a library of approved drugs and vitamins to identify those which might bind to this recently discovered 'druggable pocket' inside the SARS-CoV-2 spike protein.  The team first studied the effects of linoleic acid on the spike, using computational simulations to show that it stabilizes the closed form. Further simulations showed that dexamethasone - which is an effective treatment for COVID-19 - might also bind to this site and help reduce viral infectivity in addition to its effects on the human immune system.  The team then conducted simulations to see which other compounds bind to the fatty acid site. This identified some drugs that have been found by experiments to be active against the virus, suggesting that this may be one mechanism by which they prevent viral replication such as, by locking the spike structure in the same way as linoleic acid. The findings suggested several drug candidates among available pharmaceuticals and dietary components, including some that have been found to slow SARS-CoV-2 reproduction in the laboratory. These have the potential to bind to the SARS-CoV-2 spike protein and may help to prevent cell entry.  The simulations also predicted that the fat-soluble vitamins D, K and A bind to the spike in the same way making the spike less able to infect cells.  Dr Deborah Shoemark, Senior Research Associate (Biomolecular Modelling) in the School of Biochemistry, who modelled the spike, explained: "Our findings help explain how some vitamins may play a more direct role in combatting COVID than their conventional support of the human immune system.  "Obesity is a major risk factor for severe COVID. Vitamin D is fat soluble and tends to accumulate in fatty tissue. This can lower the amount of vitamin D available to obese individuals. Countries in which some of these vitamin deficiencies are more common have also suffered badly during the course of the pandemic. Our research suggests that some essential vitamins and fatty acids including linoleic acid may contribute to impeding the spike/ACE2 interaction. Deficiency in any one of them may make it easier for the virus to infect." Pre-existing high cholesterol levels have been associated with increased risk for severe COVID-19. Reports that the SARS-CoV-2 spike protein binds cholesterol led the team to investigate whether it could bind at the fatty acid binding site. Their simulations indicate that it could bind, but that it may have a destabilising effect on the spike's locked conformation, and favour the open, more infective conformation. Dr Shoemark continued: "We know that the use of cholesterol lowering statins reduces the risk of developing severe COVID and shortens recovery time in less severe cases. Whether cholesterol de-stabilises the "benign", closed conformation or not, our results suggest that by directly interacting with the spike, the virus could sequester cholesterol to achieve the local concentrations required to facilitate cell entry and this may also account for the observed loss of circulating cholesterol post infection." Professor Adrian Mulholland, of Bristol's School of Chemistry, added: "Our simulations show how some molecules binding at the linoleic acid site affect the spike's dynamics and lock it closed. They also show that drugs and vitamins active against the virus may work in the same way. Targeting this site may be a route to new anti-viral drugs. A next step would be to look at effects of dietary supplements and test viral replication in cells." Alison Derbenwick Miller, Vice President, Oracle for Research, said: "It's incredibly exciting that researchers are gaining new insights into how SARS-CoV-2 interacts with human cells, which ultimately will lead to new ways to fight COVID-19. We are delighted that Oracle's high-performance cloud infrastructure is helping to advance this kind of world-changing research. Growing a globally-connected community of cloud-powered researchers is exactly what Oracle for Research is designed to do."     Researchers find melatonin is effective against polycystic kidney disease Concordia University (Canada), January 26, 2021 A hormone commonly associated with sleep-wake regulation has been found to reduce cysts in fruit flies, according to Concordia researchers. It's a finding that may affect the way we treat some kidney diseases and reduce the need for kidney transplants. In a new paper published in the journal Molecules, alum Cassandra Millet-Boureima(MSc 19) and Chiara Gamberi, affiliate assistant professor of biology, write that melatonin was found to reduce cysts in the renal tubules of fruit flies. These tubules are also found in more complex mammals, including humans, where they are called nephrons. This study, which builds on previous studies by Millet-Boureima and Gamberi, was co-authored by Roman Rozencwaig and Felix Polyak of BH Bioscience in Montreal. The researchers hope that their findings can be applied to treating people suffering from autosomal dominant polycystic kidney disease. ADPKD is a genetic chronic and progressive disease characterized by the growth of dozens of cysts in the nephrons. It is incurable and affects approximately 12.5 million worldwide. Similarities big and small Because nephrons in vertebrates are embedded in other tissue, the researchers experimented on Drosophila -- the common fruit fly. "Drosophila conserves many of the renal pathway components found in vertebrates and have anatomically isolated renal tubes," Gamberi explains. "With microdissection, we can isolate the tubules and conduct biochemical and molecular analysis." The researchers bred fruit flies bearing the Bicaudal C gene mutation. It is known to cause kidney cysts in all manner of living beings, from flies to frogs to mice to humans. Over 18 days, Millet-Boureima administered melatonin to 50 Drosophila and ethanol to a control group. She then dissected the flies and scored their cysts, a process yielding a cystic index. She found that the melatonin-treated flies had much fewer and smaller cysts than the control. Because Millet-Boureima was skilled at dissecting the insects and evaluating the recovered renal tubules, she was able to avoid bias in the count. She was also able to distinguish three separate sections of the Drosophila tubule, each with its own unique function, and assign the cysts to a particular section. After testing several compounds on the same family of cells, she observed different activities along the length of the tubule. The researchers realized that they could potentially develop targeted treatment depending on the location of the cysts in a patient's nephrons. "Biologically speaking, this has a lot of potential that we will obviously develop," Gamberi says. Helping without harming Though Gamberi says melatonin has not been previously used to treat PKD, she does think it holds some promise. PKD is a chronic disease, so treatment cannot include any toxic components. This rules out chemotherapy and tumour-killing antineoplastics used in oncology, for instance. However, melatonin is entirely non-toxic and shares certain properties with antineoplastics and anti-inflammatory agents. "We know from oncology that melatonin has two effects when it is administered with chemotherapy," Gamberi explains. "First, it acts as a drug adjuvant to the chemotherapy, making it work more effectively against cancer cells. Second, it appears to protect healthy cells from the toxicity of the chemotherapy. Basically, melatonin increases the specificity of the chemotherapy. We hope that it can have a similar positive effect when used with an anti-ADPKD drug like tolvaptan, which can damage the liver." The researchers are keen to share their findings as quickly as possible. "I hope there will be more research on the drugs we tested and that we get more results that will help the PKD community," Millet-Boureima says.     Gallic acid is a dual alpha/beta-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer  Saitama Medical Center (Japan), January 20, 2021   According to news reporting from Saitama, Japan, research stated, “Several plant-derived compounds have demonstrated efficacy in pre-clinical Alzheimer’s disease (AD) rodent models. Each of these compounds share a gallic acid (GA) moiety, and initial assays on this isolated molecule indicated that it might be responsible for the therapeutic benefits observed.”  Higher concentrations of GA are found in blueberry, blackberry, strawberry, plums, grapes, mango, cashew nut, hazelnut, walnut and tea.   The news correspondents obtained a quote from the research from Saitama Medical Center, “To test this hypothesis in a more physiologically relevant setting, we investigated the effect of GA in the mutant human amyloid beta-protein precursor/presenilin 1 (APP/PS1) transgenic AD mouse model. Beginning at 12 months, we orally administered GA (20 mg/kg) or vehicle once daily for 6 months to APP/PS1 mice that have accelerated Alzheimer-like pathology. At 18 months of age, GA therapy reversed impaired learning and memory as compared with vehicle, and did not alter behavior in nontransgenic littermates. GA-treated APP/PS1 mice had mitigated cerebral amyloidosis, including brain parenchymal and cerebral vascular beta-amyloid deposits, and decreased cerebral amyloid beta-proteins. Beneficial effects co-occurred with reduced amyloidogenic and elevated nonamyloidogenic APP processing. Furthermore, brain inflammation, gliosis, and oxidative stress were alleviated. We show that GA simultaneously elevates alpha- and reduces beta-secretase activity, inhibits neuroinflammation, and stabilizes brain oxidative stress in a pre-clinical mouse model of AD. We further demonstrate that GA increases abundance of a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10, Adam10) proprotein convertase furin and activates ADAM10, directly inhibits beta-site APP cleaving enzyme 1 (BACE1, Bace1) activity but does not alter Adam10 or Bace1 transcription. Thus, our data reveal novel post-translational mechanisms for GA.” According to the news reporters, the research concluded: “We suggest further examination of GA supplementation in humans will shed light on the exciting therapeutic potential of this molecule.” This research has been peer-reviewed.     Black cumin’s anti-inflammatory potential may have airways/asthma benefits: RCT   University College London, January 27, 2021   Supplements containing oil from black cumin (Nigella sativa) may improve asthma control and lung function, says a new study.   The seed and oil of Nigella sativa have been used extensively in traditional medicine in many Middle Eastern and Asian countries for the treatment of a range of conditions, including some immune and inflammatory disorders.   The new study, published in Phytotherapy Research , found that one gram per day of the oil for four weeks led to significant improvements in scores of asthma control and a “remarkable reduction of peripheral blood eosinophil count,” wrote the authors   “Eosinophil cell plays a major role in asthma inflammation, and blood eosinophil count is considered to be a vital biomarker in asthma trials. To our knowledge, this is the first [randomized, double-blind, placebo-controlled trial] that showed a significant reduction of blood eosinophilia by [Nigella sativa oil (NSO)] among asthmatic patients.”   Scientists from University College London (UK) and King Abdulaziz University (Saudi Arabia) recruited 80 asthmatics and randomly assigned them to one of two equal groups. The participants received either capsules containing 500 mg of NSO twice per day or placebo for four weeks.   Data from the 60 people who completed the study (10 dropouts in each group) indicated that the black cumin supplement was associated with significant improvements in mean score on the Asthma Control Test, compared to placebo.   Black cumin oil products are commercially available through brands such as Life Extension. Structure-function claims made on the products include: “Modulates key regulators of inflammation” In addition, the black cumin group also experienced a significant decrease in blood eosinophils: −50 versus 15 cells/microliter.   A non-statistically significant improvement in lung function, measured as forced expiratory volume in 1 second, was also associated with the black cumin supplements.   “The NSO supplementation appeared to be effective in enhancing the control of asthma symptoms with a trend in pulmonary function improvement,” wrote the researchers. “These findings may provide an evidence for the potential benefits of NSO supplementation in the clinical management of asthma. “Future studies should follow patients for a longer period and use additional outcomes to validate the benefits of NSO in asthma.”   LSD may offer viable treatment for certain mental disorders McGill University (Quebec), January 26, 2021 Researchers from McGill University have discovered, for the first time, one of the possible mechanisms that contributes to the ability of lysergic acid diethylamide (LSD) to increase social interaction. The findings, which could help unlock potential therapeutic applications in treating certain psychiatric diseases, including anxiety and alcohol use disorders, are published in the journal PNAS. Psychedelic drugs, including LSD, were popular in the 1970s and have been gaining popularity over the past decade, with reports of young professionals claiming to regularly take small non-hallucinogenic micro-doses of LSD to boost their productivity and creativity and to increase their empathy. The mechanism of action of LSD on the brain, however, has remained a mystery. Studies in mice provide clues To conduct their study, the researchers administered a low dose of LSD to mice over a period of seven days, resulting in an observable increase in the sociability of the mice. "This increased sociability occurs because the LSD activates the serotonin 5-HT2A receptors and the AMPA receptors -- which is a glutamate receptor, the main brain excitatory neurotransmitters -- in the prefrontal cortex and also activates a cellular protein called mTORC 1," explains Danilo De Gregorio, PharmD, PhD, who is a postdoctoral fellow in the Neurobiological Psychiatry Unit at McGill and the study's first author. "These three factors, taken together, promote social interaction in mice, which is the equivalent of empathy and social behaviour in humans."  The researchers note that the main outcome of their study is the ability to describe, at least in rodents, the underlying mechanism for the behavioural effect that results in LSD increasing feelings of empathy, including a greater connection to the world and sense of being part of a large community. "The fact that LSD binds the 5-HT2A receptor was previously known. The novelty of this research is to have identified that the prosocial effects of LSD activate the 5-HT2 receptors, which in-turn activate the excitatory synapses of the AMPA receptor as well as the protein complex mTORC1, which has been demonstrated to be dysregulated in diseases with social deficits such as autism spectrum disorder," as specified by Prof. Nahum Sonenberg, Professor at the Department of Biochemistry of McGill University, world renowned expert in the molecular biology of diseases and co-lead author of the study. Using the cutting-edge technique of optogenetics, a technique where genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals, the researchers observed that when the excitatory transmission in the prefrontal cortex is de-activated, the prosocial effect of LSD was nullified, highlighting the importance of this brain region on the modulation of the behavioural effects of LSD. Moving forward to apply the findings to humans Having found that LSD increases social interaction in mice, the researchers are hoping to continue their work and to test the ability of LSD to treat mutant mice displaying the behavioural deficits similar to those seen in human pathologies including autism spectrum disorders and social anxiety disorders. The hope is to eventually explore whether micro-doses of LSD or some novel derivates might have a similar effect in humans and whether it could also be a viable and safe therapeutic option.  "Social interaction is a fundamental characteristic of human behaviour," notes the co-lead author Dr. Gabriella Gobbi, Professor in the Department of Psychiatry at McGill and psychiatrist at the McGill University Health Centre. "These hallucinogenic compounds, which, at low doses, are able to increase sociability may help to better understand the pharmacology and neurobiology of social behavior and, ultimately, to develop and discover novel and safer drugs for mental disorders."   Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction   University of Naples (Italy), January 28, 2021   Studies from University of Naples Federico II Describe New Findings in Insulin Resistance (Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats)   A new study on Endocrine System Diseases and Conditions - Insulin Resistance is now available. According to news reporting originating in Naples, Italy, research stated, "Virgin olive oil is an essential component of the Mediterranean diet. Its antioxidant and anti-inflammatory properties are mainly linked to phenolic contents."   The news reporters obtained a quote from the research from the University of Naples Federico II, "This study aims to evaluate the beneficial effects of a polyphenol-rich virgin olive oil (HPCOO) or olive oil without polyphenols (WPOO) in rats fed high-fat diet (HFD). Male Sprague-Dawley rats were divided into four groups based on the different types of diet: (I) standard diet (STD); (II) HFD; (III) HFD containing WPOO, and (IV) HFD containing HPCOO. HPCOO and WPOO induced a significant improvement of HFD-induced impaired glucose homeostasis (by hyperglycemia, altered oral glucose tolerance, and HOMA-IR) and inflammatory status modulating pro-and anti-inflammatory cytokines (TNF-a, IL-1, and IL-10) and adipokines. Moreover, HPCOO and less extensively WPOO, limited HFD-induced liver oxidative and nitrosative stress and increased hepatic fatty acid oxidation. To study mitochondrial performance, oxidative capacity and energy efficiency were also evaluated in isolated liver mitochondria. HPCOO, but not WPOO, reduced H O release and aconitase activity by decreasing degree of coupling, which plays a major role in the control of mitochondrial reactive oxygen species emission."   According to the news reporters, the research concluded: "HPCOO limits HFD-induced insulin resistance, inflammation, and hepatic oxidative stress, preventing nonalcoholic fatty liver disease progression."   For more information on this research see: Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats.   

Who wants to hear all about PCOS and fertility??   Well you came to the right place! In this episode, Caitlin and Sophia dive in to the #1 most common cause of fertility struggles in women: PCOS   So… what is it?   PCOS is an endocrine problem, meaning it is a hormone imbalance. It used to be thought of as a gynecological problem, but as science has advanced we now know PCOS goes beyond female sex organs.   Dietitians like us actually cannot diagnose PCOS, though both Caitlin and Sophia often have women come to them for fertility help, and when we send them back to their doc for some testing it’s discovered that they DO have PCOS.   PCOS is diagnosed using certain criteria (Rotterdam Criteria), and it’s more of a culmination of signs and symptoms. The symptoms your doctors typically look for are:   Cystic ovaries - ovaries with multiple cysts diagnosed with ultrasound High androgens - Testosterone, DHEA-S, Androsterone, etc. elevated higher than normal for women Excess body hair Male pattern baldness Lack of/delayed ovulation - your cycles are very irregular and ovulation is rare or absent   Caitlin was a mere teen when she was diagnosed with PCOS, and when she innocently asked her doc what this meant, his cold reaction was “PCOS is the #1 reason women can’t get pregnant”. Which, by the way, is a HORRIBLE thing to say to anyone, let alone a teenager!   **If you only take one thing away from this episode, let it be know that PCOS is NOT an infertility diagnosis! If left untreated, PCOS can certainly impact fertility; but PCOS is very treatable! This diagnosis does not mean you will never be a mom!!!!!**   Treating the factors that influence PCOS greatly increase your chances of getting pregnant!   So, what if you simply suspect you may have PCOS?   Cycles longer than 35 days Acne Hair loss Body hair growth Difficulty losing weight Excess weight around your belly How does PCOS affect fertility?   If you’re ovulating every 28-30 days or so, you’ll have roughly 12 chances to get pregnant in a year. If you, someone with PCOS, only ovulates every 50-60 days, you will have far less chances to get pregnant in a given year.   Why does this occur?   Almost always, the root cause of PCOS has something to do with insulin resistance. In simple terms, this means your body doesn’t manage your blood sugar well. Insulin is a hormone that moves the sugar/fuel in your blood into your body’s tissues and cells. Insulin resistance is where your body stops listening to the message of insulin, requiring your body to crank up the volume on insulin to get the job done. This causes ovaries to get overstimulated, increasing testosterone and other male hormone levels; causing many of the symptoms of PCOS   Brains are greatly affected too. Your brain has glands that make hormones that control ovulation. In healthy bodies, your brain makes a surge of luteinizing hormone (LH) and follicle stimulating hormone (FSH) just before ovulation. In bodies with PCOS, these hormones kick into high gear far too frequently as your body tries and tries to ovulate. This is why it’s so helpful to get lab work done so we can address exactly what is happening with each of these hormones.   Brains also make a hormone called prolactin. When prolactin is at its best, it helps nursing moms make milk for their babies. Part of the overstimulation of the ovaries and brain that come with PCOS cause your brain to make too much prolactin. High prolactin is good if you’re nursing a baby because it also tells your ovaries not to ovulate, since your body is still sustaining the life of the baby you’re nursing. However, if you have PCOS and your prolactin is too high, this hormone holds off ovulation and makes it harder to become pregnant.   Estrogen is also higher in many women with PCOS. This, again, can be because your body is trying and trying to ovulate. Estrogen can also be too high due to excess body fat, a piece of the cruel cycle of PCOS. Estrogen being too high is particularly problematic when it comes to the hormonal rhythm of ovulation. When estrogen dominates other hormones (like progesterone), many of the symptoms of PMS/PCOS are amplified. Migraines, cramps, anxiety, heavy bleeding, etc. are all symptoms of high estrogen to progesterone.   The last noteworthy hormone of PCOS is cortisol, the stress hormone. This hormone causes blood sugar to rise and thwarts the function of insulin, making your body naturally more insulin resistant. This is great if you’re in the midst of a bloody battle; not so good if you’re overwhelmed by the daily stress of life. While we cannot change the stressors that occur in your life, we do help each of our patients manage stress and react to stress differently.   These hormones are why both Caitlin and Sophia both do functional hormone testing as a part of their practices! We want to target your specific symptoms and root causes! No two women are the same, and there is no way to say simply by looking at symptoms what each of your hormones are doing.   This is also why advice from medical professionals that sounds anything like “lose some weight” is so infuriating! It’s not only unhelpful, but it’s psychologically damaging. Remember, one of the symptoms of PCOS is excess weight in the midsection. So, it’s not helpful to be told the very symptoms you’re there to address is same as the treatment.   ** Cue Sophia rant about doctors telling women to lose weight **   Another great test to run is an insulin assay. This includes a 2 hour glucose tolerance test and measuring insulin markers like the Homa-IR test   These labs we all mentioned are tests that Caitlin and Sophia use all the time in our practices! However, this is not a comprehensive list of all the hormones and tests to look at with PCOS. Even if you have done all this testing, and you still can’t figure out what’s up; don’t give up! There are more stones to overturn and Sophia or Caitlin are poised and read to help you get some answers!   What could happen if you go to the OB/GYN and say you want to get pregnant with PCOS Get a full panel of labs on varying dates of your cycle Your doc might give you Metformin (glucophage) and are told to come back in a few months if you’re not pregnant Your doc might also give you Clomid (clomiphene) or letrozole to try and trigger ovulation   You might also be simply told to lose 10% of your bodyweight… which is not helpful, as we’ve established.   Stay tuned to next week’s episode where we talk about REAL LIFE SOLUTIONS to PCOS fertility struggles! Tune in and be amazed.

The Gary Null Show is here to inform you on the best news in health, healing, the environment. Multivitamin, mineral supplement linked to less-severe, shorter-lasting illness symptoms Oregon State University, August 18, 2020   Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo. The findings by Oregon State University researchers were published in the journal Nutrients. The research by scientists at OSU's Linus Pauling Institute involved 42 healthy people ages 55 to 75 and was designed to measure the supplement's effects on certain immune system indicators. It also looked at bloodstream levels of zinc and vitamins C and D while taking the supplement, as these micronutrients are important for proper immune function. The immune indicators, including white blood cells' ability to kill incoming pathogens, were unaltered in the group receiving the supplement.  The multivitamin group showedimproved vitamin C and zinc status in the blood. Most intriguingly, illness symptoms reported by this group were less severe and went away faster than those experienced by the placebo group.  The same percentage of participants in each group reported symptoms, but days of sickness in the supplement group averaged fewer than three compared to more than six for the placebo group.  "The observed illness differences were striking," said corresponding author Adrian Gombart, professor of biochemistry and biophysics in the OSU College of Science and a principal investigator at the Linus Pauling Institute. "While the study was limited to self-reported illness data and we did not design the study to answer this question, the observed differences suggest that additional larger studies designed for these outcomes are warranted - and, frankly, overdue." As people get older, the risk of vitamin and mineral deficiencies that contribute to age-related immune system deficiencies rises. Across the United States, Canada and Europe, research suggests more than one-third of older adults are deficient in at least one micronutrient, often more than one. "That likely contributes to a decline in the immune system, most often characterized by increased levels of inflammation, reduced innate immune function and reduced T-cell function," Gombart said. "Since multiple nutrients support immune function, older adults often benefit from multivitamin and mineral supplements. These are readily available, inexpensive and generally regarded as safe." The multivitamin supplement used in the study focused on vitamins and minerals typically thought to help immunity. It contained 700 micrograms of vitamin A; 400 international units of vitamin D; 45 milligrams of vitamin E; 6.6 milligrams of vitamin B6; 400 micrograms of folate; 9.6 micrograms of vitamin B12; 1,000 milligrams of vitamin C; 5 milligrams of iron; 0.9 milligrams of copper; 10 milligrams of zinc; and 110 micrograms of selenium. "Supplementation was associated with significantly increased circulating levels of zinc and vitamin C, and with illness symptoms that were less severe and shorter lasting," Gombart said. "This supports findings that stretch back decades, even to the days of Linus Pauling's work with vitamin C. Our results suggest more and better designed research studies are needed to explore the positive role multivitamin and mineral supplementation might play in bolstering the immune system of older adults."     Honey found to be a better treatment for upper respiratory tract infections than traditional remedies Oxford University, August 19, 2020 A trio of researchers at Oxford University has found that honey is a better treatment for upper respiratory tract infections (URTIs) than traditional remedies. In their paper published in BMJ Evidence-based Medicine, Hibatullah Abuelgasim, Charlotte Albury, and Joseph Lee describe their study of the results of multiple clinical trials that involved testing of treatments for upper respiratory tract infections (URTIs) and what they learned from the data. Over the past several years, the medical community has grown alarmed as bacteria have developed resistance to antibacterial agents. Some studies have found that over-prescription of such remedies is hastening the pace. Of particular concern are antibacterial prescriptions written for maladies that they are not likely to help, simply due to demands from patients. One such case is often URTIs, the vast majority of which are caused by viruses, not bacteria. Because of such cases, scientists have been looking for other remedies for these infections, and one therapy in particular has begun to stand out: honey. Anecdotal evidence has suggested that honey can be used to treat colds in general and coughs in particular—people have been using it as a therapy for thousands of years. In this new effort, the researchers looked at the results of multiple clinical trials testing the effectiveness of therapies against URTIs. In all, the team looked at data from 14 clinical trials involving 1,761 patients. In analyzing the data from all of the trials combined, the researchers found that the trials had included studies of virtually all of the traditional remedies such as over-the-counter cold and sinus medicines as well as antibiotics—and honey. They found that honey proved to be the best therapy among all of those tested. In addition to proving more effective in treating coughing (36 percent better at reducing the amount of coughing and 44 percent better at reducing coughing severity), it also led to a reduction in average duration of infection by two days. The researchers note that the reason honey works as a treatment for URTIs is because it contains hydrogen peroxide—a known bacteria killer—which also makes it useful as a topical treatment for cuts and scrapes. Honey is also of the right consistency—its thickness works to coat the mouth and throat, soothing irritation.   High intensity physical activity in early life could lead to stronger bones in adulthood University of Bristol (UK), August 17 2020   The research, which analysed data from 2,569 participants of the Children of the 90s health study, found that more time spent doing moderate-to-vigorous intensity physical activity (MVPA) from age 12 years was associated with stronger hips at age 25 years, whereas time spent in light intensity activity was less clearly associated with adult hip strength. Peak bone mass occurs in young adulthood and is considered to be a marker of the risk of fracture and osteoporosis in later life. Hip fractures make up a large proportion of the osteoporosis disease burden.  Researchers looked at data from healthy individuals who had physical activity measured up to 4 times using accelerometers worn as part of clinical assessments at age 12, 14, 16 and 25 years. This is a device that measures a person's movement for the whole time they wear it. Researchers also found evidence to suggest that adolescent MVPA was more important than MVPA in adulthood, and that MVPA in early adolescence may be more important than in later adolescence. There was also some evidence that higher impact activity (consistent with jumping; assessed once in a subsample in late adolescence using custom accelerometer) was related to stronger hips at age 25. Dr Ahmed Elhakeem, lead author and Senior Research Associate in Epidemiology, said: "The unique availability of repeated accelerometer assessments over many years beginning at age 12 within the Children of the 90s cohort, allowed us to describe the trajectory of time spent in different physical activity intensities through early life and to examine how this might relate to adult hip strength. The results highlight adolescence as a potentially important period for bone development through high intensity exercise, which could benefit future bone health and prevent osteoporosis in later life. We have also confirmed other studies showing that levels of MVPA decline through adolescence. Our findings show it is really important to support young people to remain active at this age"  Francesca Thompson, Clinical and Operations Director at the Royal Osteoporosis Society (ROS), said: "The ROS is working closely at the moment with Public Health England to review the importance of exercise for bone health in children. The findings from this study are welcome as they provide further evidence that children need to be doing moderate to vigorous intensity physical activity during their early adolescence to maximise bone strength in later life and reduce the risk of painful fractures. Supporting and encouraging young people to be more physically active needs to be a priority for bone as well as general health."   Magnesium supplementation associated with improved vitamin D status in postmenopausal women University of Granada (Spain), August 17, 2020   According to news originating from Granada, Spain,  the research stated, “Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D.” Our news editors obtained a quote from the research from University of Granada: “A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44-76 years of age were included. Two randomized groups-placebo and magnesium (500 mg/day)-were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography-tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects.” According to the news editors, the research concluded: “The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (* * p* * < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.”     High fructose diet in pregnancy impacts metabolism of offspring, study finds University of Otago (New Zealand), August 18, 2020   An increased level of fructose intake during pregnancy can cause significant changes in maternal metabolic function and milk composition and alter the metabolism of their offspring, researchers from the University of Otago, Wellington, have found. The research, which was led by Dr Clint Gray, a Research Fellow in the Department of Paediatrics and Child Health, found increasing the fructose in the diets of female guinea pigs led to highly significant and consistent changes in the free fatty acids circulating in the blood of their offspring. This was despite the offspring consuming no fructose themselves.  The research is published in the international journal Frontiers in Endocrinology.  First author, PhD student Erin Smith, says "previous research has shown poor quality nutrition during pregnancy can predispose offspring to long-term consequences, including the development of obesity, diabetes and cardiovascular disease later in life".  "However, there has been a lack of data examining the impact of increased fructose intake before and during pregnancy and subsequent adverse effects on lactation, foetal development and offspring metabolic function." The two experimental groups were fed either a control diet or a fructose diet prior to and during pregnancy. The fructose group was given supplementary fructose water to replicate increased sugar-sweetened beverage intake 60 days prior to mating and until the delivery of their offspring. Fructose made up 16.5 per cent of their diets, closely resembling the average human consumption of fructose/sugar in Western countries, which is estimated at about 14 per cent of average daily caloric intake.  "We found fructose had a significant impact on a pregnant females' metabolic status and the free fatty acid content of their milk. We also provide the first evidence that offspring born from fructose-fed mothers display a very specific pattern of increased free fatty acids and altered lipid metabolism that persists throughout early life." Ms Smith says it is well known that increased levels of circulating free fatty acids increases the risk of obesity, insulin resistance, type 2 diabetes and cardiovascular disease - with increased fatty acid synthesis shown to occur following fructose consumption. She says the evidence suggests suboptimal maternal diets, such as diets high in fructose and refined sugars, may be contributing to the rise in metabolic diseases in humans observed during the past 40 to 50 years. "Our study emphasises the importance of limiting added refined fructose, such as sugar-sweetened beverages, and striving for a more nutritionally balanced diet in women prior to and during pregnancy and lactation."       Sleep makes relearning faster and longer-lasting University of Lyon (France). August 14, 2020   Getting some sleep in between study sessions may make it easier to recall what you studied and relearn what you've forgotten, even 6 months later, according to new findings from Psychological Science, a journal of the Association for Psychological Science.   "Our results suggest that interleaving sleep between practice sessions leads to a twofold advantage, reducing the time spent relearning and ensuring a much better long-term retention than practice alone," explains psychological scientist Stephanie Mazza of the University of Lyon. "Previous research suggested that sleeping after learning is definitely a good strategy, but now we show that sleeping between two learning sessions greatly improves such a strategy."   While studies have shown that both repeated practice and sleep can help improve memory, there is little research investigating how repetition and sleep influence memory when they are combined. Mazza and colleagues hypothesized that sleeping in between study sessions might make the relearning process more efficient, reducing the effort needed to commit information to memory.   A total of 40 French adults were randomly assigned to either a "sleep" group or a "wake" group. At the first session, all participants were presented with 16 French-Swahili word pairs in random order. After studying a pair for 7 seconds, the Swahili word appeared and participants were prompted to type the French translation. The correct word pair was then shown for 4 seconds. Any words that were not correctly translated were presented again, until each word pair had been correctly translated.   Twelve hours after the initial session, the participants completed the recall task again, practicing the whole list of words until all 16 words were correctly translated.   Importantly, some participants completed the first session in the morning and the second session in the evening of the same day ("wake" group); others completed the first session in the evening, slept, and completed the second session the following morning ("sleep" group).   In the first session, the two groups showed no difference in how many words they could initially recall or in the number of trials they needed to be able to remember all 16 word pairs.   But after 12 hours, the data told another story: Participants who had slept between sessions recalled about 10 of the 16 words, on average, while those who hadn't slept recalled only about 7.5 words. And when it came to relearning, those who had slept needed only about 3 trials to be able to recall all 16 words, while those who had stayed awake needed about 6 trials.   Ultimately, both groups were able to learn all 16 word pairs, but sleeping in between sessions seemed to allow participants to do so in less time and with less effort.   "Memories that were not explicitly accessible at the beginning of relearning appeared to have been transformed by sleep in some way," says Mazza. "Such transformation allowed subjects to re-encode information faster and to save time during the relearning session."   The memory boost that participants got from sleeping between sessions seemed to last over time. Follow-up data showed that participants in the sleep group outperformed their peers on the recall test 1 week later. The sleep group showed very little forgetting, recalling about 15 word pairs, compared to the wake group, who were able to recall about 11 word pairs. This benefit was still noticeable 6 months later.   The benefits of sleep could not be ascribed to participants' sleep quality or sleepiness, or to their short-term or long-term memory capacity, as the two groups showed no differences on these measures.   The results suggest that alternating study sessions with sleep might be an easy and effective way to remember information over longer periods of time with less study, Mazza and colleagues conclude.       Meta-analysis adds evidence to chromium supplementation's glucose control benefits in diabetics Lorestan University of Medical Sciences (Iran), August 15, 2020   A systematic review and meta-analysis published on July 27, 2020 in Pharmacological Research found reductions in fasting plasma glucose, insulin, hemoglobin A1c (HbA1c, a marker of long term glucose control) and insulin resistance in men and women with type 2 diabetes who supplemented with the mineral chromium.  For their analysis, Omid Asbaghi of Lorestan University of Medical Sciences and colleagues selected 23 randomized, controlled trials that evaluated the effects of supplementing with chromium on various glycemic control indexes. Doses used in the studies ranged between 50 micrograms (mcg) and 1,000 mcg per day consumed from four to 25 weeks. Eleven of the trials evaluated a chromium dosage within a 400 to 600 mcg range.  Analysis of 22 trials that reported fasting plasma glucose levels concluded that chromium supplementation was associated with an average reduction of 19.0 milligrams per deciliter (mg/dL) in comparison with the placebo. Trials of at least 12 weeks duration were associated with a far greater average decrease of 58.74 mg/dL in association with chromium.  Of the 14 trials that reported insulin levels, levels declined by an average of 1.7784 µIU/mL among subjects who received chromium compared to the placebo, with trials that lasted 12 weeks or longer associated with a decrease of 3.47 µIU/mL.  For the 22 trials that reported HbA1c, supplementation with chromium was associated with an average decrease of 0.71%, which improved to a significant 1.70% reduction when trials of 12 weeks duration or more were examined. Homeostatic model assessment for insulin resistance (HOMA-IR) also decreased significantly among participants who received chromium.  The authors observed that chromium plays a role in carbohydrate and lipid metabolism and may enhance insulin sensitivity. Other nutrients that have been associated with a lower risk of type 2 diabetes include vitamins A, C, D and E, beta-carotene, calcium, magnesium, potassium and zinc. “Present systematic review and meta-analysis of all available published randomized trials up to 2020 found a significant reduction in all glycemic control indices such as fasting plasma glucose, insulin, HbA1c and HOMA-IR levels after chromium supplementation,” they wrote. “Furthermore, long term intervention contributed to greater reduction of all mentioned indices.” “The results of the current meta‐analysis study might support the use of chromium supplementation for the improvement of glycemic control indices in T2DM patients,” they concluded.       Mangiferin: The Health-Boosting Antioxidant in Mangos GreenMedInfo, August 12th 2020    Mangiferin, a polyphenol found in mango fruit and plant extracts, possesses potent antioxidant and anti-inflammatory properties. Mangiferin has been shown to have beneficial effects on gastrointestinal health, Type 2 diabetes and cardiovascular health, and may have anticancer properties Mango, a type of juicy stone fruit native to eastern Asia and India, is rich in omega-3 and omega-6 fatty acids, fiber, antioxidants, micronutrients and minerals, and a unique polyphenol called mangiferin.[i] While mango itself has long been touted for its health benefits, researchers are becoming increasingly interested in mangiferin, which can be found in the leaves, fruit, stone, kernel and stems of the mango plant.[ii] Studies show that mangiferin extracts may have beneficial effects on lifestyle-related disorders and degenerative diseases, and researchers are eager to understand and utilize this potent polyphenol. Antioxidant and Anti-Inflammatory Potential of Mangiferin Mangiferin is a powerful antioxidant that modulates glucose metabolism and shows enhanced antioxidant capabilities in both inflammatory and pro-inflammatory conditions.[iii] Mangiferin antioxidants have also been shown to protect against liver damage and lower peroxidation in human peripheral blood lymphocytes, and mangiferin may have radioprotective properties thanks to its ability to suppress free radicals in cells.[iv],[v] Additionally, mangiferin's anti-inflammatory benefits have been demonstrated in both the liver and heart, and researchers have discovered that mangiferin can protect against lipid peroxidation and oxidative stress by up-regulating the expression of Nrf2, a transcription factor responsible for the regulation of protective antioxidants and detoxification responses.[vi],[vii] Mangiferin's anti-inflammatory effects have also been demonstrated in the lungs, where it can improve acute lung injury by reducing systemic and pulmonary inflammationresponses.[viii] Overall, mangiferin's anti-inflammatory properties have been demonstrated to reduce both macro and microscopic damage in various organs and tissues, making it a potential preventative therapy for a variety of disorders.[ix] Many of the benefits of mangiferin come from these strong antioxidant and anti-inflammatory properties. Researched benefits of mangiferin include: Mangiferin Extract May Protect Against Diabetes More than 80% of all diabetes cases are Type 2, which is associated with a lowered ability to increase glucose utilization in skeletal muscle tissue and adipose tissue.[x] This decrease in glucose metabolism and increased insulin increases the risk for disorders like cardiovascular disease, fatty liver and renal diseases.[xi] In one study, researchers demonstrated that mangiferin extract significantly reduced kidney weight while enhancing enzymatic activity and protein expression after just nine weeks.[xii] Other studies have shown that mangiferin extract can also reduce low-density lipoprotein (LDL) cholesterol and improve oral-glucose tolerance after just 28 days.[xiii] Mangiferin Boosts Gastrointestinal Health Mangiferin has gastroprotective effects, leading researchers to believe it could be a useful therapeutic measure against gastric complications including diarrhea, abdominal pain, weight loss and anemia associated with Crohn's disease and ulcerative colitis.[xiv] These effects are likely due to mangiferin's antioxidant and anti-inflammatory properties, which both contribute to the development of gastrointestinal disorders.[xv] In other studies, researchers have found that mangiferin improves postoperative ileus, a short-term disturbance of gastrointestinal motility after surgery.[xvi] Mangiferin improves intestinal transit by reducing the intestinal inflammatory response and decreasing pro-inflammatory cytokine levels in the plasma, improving gastrointestinal transit in both normal and constipated subjects.[xvii],[xviii] Mangiferin Has Anticancer Properties Researchers believe that one root cause of carcinogenesis is oxidative stress and have long searched for natural, polyphenolic antioxidant compounds that could mediate oxidative damage in the body. One study found that mangiferin's antioxidant capabilities may stall the progression of carcinogenesis and induce apoptosis (cell death) on cancer cells.[xix] Mangiferin is demonstrated to have protective effects against several cancers, including breast, colon, neural, skin and cervical cancers, by lowering oxidative stress and suppressing DNA damage in cells in various studies.[xx] Mangiferin Has Immunomodulatory Properties Mangiferin's strong immunomodulatory characteristics come from its ability to both reduce oxidative stress in lymphocytes, neutrophils and macrophages, and also enhance the number and activity of immune cells in your body.[xxi],[xxii] Additionally, mangiferin inhibits lipid peroxidation, which researchers believe may account for the reduction of radiation-induced DNA damage to immune cells and explain mangiferin's strong immune-stimulating and anticancer effects.[xxiii] Mangiferin Protects Against Cardiovascular Disease Mangiferin may play a significant cardiovascular-protective role by decreasing fatty acids, cholesterol and triglycerides and decreasing the inflammatory process in heart tissue.[xxiv] Mangiferin treatment is also shown to increase enzymatic activity and reduce the formation of lipid peroxides, which researchers use as a marker for cardiovascular disease risk and vascular cognitive impairment disorders.[xxv] Given that mangiferin exhibits little to no toxicity and has anti-inflammatory and antioxidant benefits, there is strong evidence that mangiferin can be used as an alternative or preventive therapy against a variety of illnesses.[xxvi] However, it has a low water solubility and oral bioavailability and researchers must find an effective dosage and enhance its absorption rate before it can effectively be used in clinical settings.  

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - https://shop.drberg.com/veggie-solution-flavored-sweetened?utm_source=Podcast&utm_medium=AGM(Anchor) • Plain (Unflavored) - https://shop.drberg.com/veggie-solution-plain?utm_source=Podcast&utm_medium=AGM(Anchor) Take Dr. Berg's Free Keto Mini-Course! In this podcast, we're going to talk about pregnancy and diabetes. If you have pre-diabetes, insulin resistance, or you're a diabetic while pregnant, there are several things you need to know. What is insulin resistance? — This is a condition where your body is not able to absorb insulin. Your body has to make more insulin than it needs, and that excess insulin creates a lot of problems. Your blood sugars may be normal, but you have a big problem under the surface. HOMA-IR is a test you can take before you get pregnant to check and see if you have insulin resistance. Complications from having blood sugar problems while pregnant: • The baby is more likely to become a diabetic • There is a higher risk of a stillbirth • The mother may have a problem with fertility • The baby may have stunted growth • The baby may have birth defects • The baby may have pre-eclampsia Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast&utm_medium=Anchor TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast&utm_medium=Post&utm_campaign=Daily%20Post YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast&utm_medium=Anchor DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast&utm_medium=Anchor MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast&utm_medium=Anchor DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast&utm_medium=Anchor

We get a lot of questions from our clients about postprandial fatigue. Never heard of it? Well you’ve certainly familiar with the term “food coma” - and perhaps with the experience of being in one. What causes this phenomenon and why does it affect some people more than others? Is it normal to need a nap after lunch?  On this podcast I’m joined by NBT Scientific Director Megan Hall to talk about postprandial fatigue - the sleepiness, difficulty focusing, and even dizziness or nausea that strikes after consuming a meal. Megan talks about some of the biological processes behind the need for a post-meal snooze, and when to suspect a deeper pathology. She also offers practical tips to help you resolve your own postprandial fatigue. Thank you everyone who so generously supports this podcast on Patreon - without your support, we wouldn’t be able to keep this podcast independent and free of ads. So thank you. And just a reminder - as a Patreon supporter - not only do you have our eternal gratitude, but also... You get some awesome gifts - including 20-35% discounts on all supplements we recommend when working with clients, which saves many of our supporters $50-$100 a month over what they were previously paying on Amazon. So by supporting the podcast, they’re actually spending LESS money each month. In addition to that, you can also get access to our Office Hours, where Megan answers questions twice a week. You can submit all your own questions, as well as listen to all the replays, covering everything from krill oil to mitochondrial support. We’ve worked really hard to make sure that the bonuses you get are actually way more valuable than what you pay whatever level you choose to support us at. So if you’d like to support the podcast and get access to the discounts and Office Hours, just head over to NBT.link and sign up there. Here’s the outline of this interview with Megan Hall: [00:04:25] Common symptoms of postprandial fatigue. [00:05:46] Reactive hypoglycemia; Study: Johnson, Debra D., Kay E. Dorr, and Wendell M. Swenson. "Reactive hypoglycemia." JAMA 243.11 (1980): 1151-1155.  [00:06:35] Diagnosing reactive hypoglycemia; Study: CHALEW, STUART, et al. "Diagnosis of reactive hypoglycemia: pitfalls in the use of the oral glucose tolerance test." Southern Medical Journal 79.3 (1986): 285-287. [00:09:00] Symptoms and causes of hypoglycemia. [00:09:37] Increased insulin sensitivity; Studies: 1. Brun, J. F., et al. "Increased insulin sensitivity and basal insulin effectiveness in postprandial reactive hypoglycaemia." Acta Diabetologica 33.1 (1996): 1-6; 2. Vexiau, P., B. Legoff, and G. Cathelineau. "Insulin and cortisol secretion during OGTT in patients with reactive hypoglycaemia with or without clinical symptoms." Hormone and metabolic research 15.09 (1983): 419-421. [00:09:47] Hypocortisolism; Studies: 1. Meyer, Gesine, et al. "Nocturnal hypoglycemia identified by a continuous glucose monitoring system in patients with primary adrenal insufficiency (Addison's disease)." Diabetes Technology & Therapeutics 14.5 (2012): 386-388; 2. Christiansen, Jens Juel, et al. "Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure." The Journal of Clinical Endocrinology & Metabolism 92.9 (2007): 3553-3559. [00:10:05] Hypothyroidism; Studies: 1. Kalra, Sanjay, Ambika Gopalakrishnan Unnikrishnan, and Rakesh Sahay. "The hypoglycemic side of hypothyroidism." Indian Journal of Endocrinology and Metabolism 18.1 (2014): 1; 2. Yadav, Tek Chand, et al. "Recurrent hypoglycemia: An unusual finding of hypothyroidism." Thyroid Research and Practice 14.3 (2017): 127. [00:10:53] What to do about hypoglycemia. [00:13:09] Accelerated gastric emptying. [00:16:20] Reactive hypoglycemia after exercise. [00:18:51] Postprandial hyperglycemia; Study: Gerich, John E. "Clinical significance, pathogenesis, and management of postprandial hyperglycemia." Archives of internal medicine 163.11 (2003): 1306-1316. [00:20:38] Problems associated with hyperglycemia; Studies: 1. Ceriello, Antonio, et al. "Meal-induced oxidative stress and low-density lipoprotein oxidation in diabetes: the possible role of hyperglycemia." Metabolism 48.12 (1999): 1503-1508; 2. Ceriello, Antonio, et al. "Meal-generated oxidative stress in type 2 diabetic patients." Diabetes care 21.9 (1998): 1529-1533; 3. Cavalot, F. "Do data in the literature indicate that glycaemic variability is a clinical problem? Glycaemic variability and vascular complications of diabetes." Diabetes, Obesity and Metabolism 15.s2 (2013): 3-8; 4. Ceriello, Antonio, et al. "Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short-and long-term simvastatin treatment." Circulation 106.10 (2002): 1211-1218; 5. Tibaldi, Joseph. "Importance of postprandial glucose levels as a target for glycemic control in type 2 diabetes." Southern medical journal 102.1 (2009): 60-66. [00:21:24] Insulin resistance. [00:21:39] Video: PAH 2016 - A systems analysis approach to insulin resistance, with Dr. Tommy Wood. [00:23:02] What to do: Look at diet; 1. Krebs, Jeremy D., et al. "Improvements in glucose metabolism and insulin sensitivity with a low-carbohydrate diet in obese patients with type 2 diabetes." Journal of the American College of Nutrition 32.1 (2013): 11-17; 2. Lin, Po-Ju, and Katarina T. Borer. "Third exposure to a reduced carbohydrate meal lowers evening postprandial insulin and GIP responses and HOMA-IR estimate of insulin resistance." PloS one 11.10 (2016): e0165378; 3. MacDonald, Ian A. "A review of recent evidence relating to sugars, insulin resistance and diabetes." European journal of nutrition 55.2 (2016): 17-23; 4. Bradley, Una, et al. "Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial." Diabetes 58.12 (2009): 2741-2748. [00:28:46] Mediterranean diet; Study: Guasch-Ferré, Marta, et al. "Dietary polyphenols, Mediterranean diet, prediabetes, and type 2 diabetes: a narrative review of the evidence." Oxidative Medicine and Cellular Longevity 2017 (2017). [00:29:56] Endotoxemia and insulin resistance 1. Moreira, AP Boroni, and R. de Cássia Gonçalves Alfenas. "The influence of endotoxemia on the molecular mechanisms of insulin resistance." Nutrición hospitalaria 27.2 (2012): 382-390; 2. Cani, Patrice D., et al. "Metabolic endotoxemia initiates obesity and insulin resistance." Diabetes 56.7 (2007): 1761-1772. [00:30:24] Megan's outline for this podcast.  [00:31:19] When fatigue after a meal might be normal. [00:33:08] Article: Why a pandemic flu shot caused narcolepsy. [00:33:49] Both high fat and high carb meals can cause sleepiness; Study: Wells, Anita S., et al. "Effects of meals on objective and subjective measures of daytime sleepiness." Journal of applied physiology 84.2 (1998): 507-515. [00:33:56] Intestinal stimulation can cause sleepiness; Kukorelli, Tibor, and Gábor Juhász. "Electroencephalographic synchronization induced by stimulation of small intestine and splanchnic nerve in cats." Electroencephalography and clinical neurophysiology 41.5 (1976): 491-500. [00:34:20] Sleepiness after eating vs. just chewing; Study: MJ Harnish, SR Greenleaf, WC Orr, “A comparison of feeding to cephalic stimulation on postprandial sleepiness.” Physiology & behavior 64.1 (1998):93-96. [00:34:38] Cholecystokinin (CCK) may affect the alert centers in the brain; Study: Wells, Anita S., et al. "Influences of fat and carbohydrate on postprandial sleepiness, mood, and hormones." Physiology & behavior 61.5 (1997): 679-686. [00:37:13] Thermogenesis; Study: Zammit, Gary K., et al. "Postprandial sleep and thermogenesis in normal men." Physiology & behavior 52.2 (1992): 251-259. [00:37:40] Summary: How to fix the problem. [00:38:43] Nutrisense for continuous glucose monitoring (CGM). [00:46:29] Timing your walk with glucose peak; Study: Reynolds, Andrew N., and Bernard J. Venn. "The timing of activity after eating affects the glycaemic response of healthy adults: a randomised controlled trial." nutrients 10.11 (2018): 1743. [00:51:01] Support NBT on Patreon to access the forum.  

To learn more and apply to work one-on-one with Rachel, visit her website: https://www.killinitketo.com/ Join Rachel’s weekly newsletter: https://www.killinitketo.com/newsletter  In this episode, Rachel chats about the ‘best diet’ for body recomposition, why inches are not always equal to pounds in terms of fat loss, how long it takes to lose weight on keto, her thoughts on exogenous ketones, and an explanation for elevated blood glucose levels after a prolonged low-carb, keto diet. Top Takeaways: Rachel’s recommendations for diet to achieve optimal body recomposition. Rachel explains why losing pounds in body weight is not the same as losing inches off of body size. Why losing weight with a ketogenic diet (or any diet) will have varied results depending on individual start-points. Why exogenous ketones are not a “magic wand” for the ketogenic diet. Rachel discusses whether it is necessary to hit an exact ketone reading of 0.5 and if other ketone amounts can be useful. Rachel shares possible causes for why some people following a low-carb/keto lifestyle may experience elevated blood glucose levels. Show Notes: [1:00] Rachel announces the winners of the Redmond Life Giveaway! Please send an email to rachel@killinitketo.com with your full name, shipping address, and email. Congrats!! More giveaways to come in future episodes :) Robin OS Holistic Learner Ketocarnivoremama [2:30] Rachel’s recommendation for the best way to nourish your body with food to rebuild. She stresses the importance of choosing a diet you can adhere to long-term, gathering sufficient information to know if the diet is a good fit, and following what she calls the Whole Food Rule (Eating 80%-90% foods that either grew from the earth or once had a face). [4:20] Diet is not the only crucial component when it comes to changing the general composition of your body.  [7:30] Rachel explains the difference between scale weight loss and body size weight loss. [8:00] Proper scale use consists of taking a weekly average, not daily fluctuations. Check out this blog post for how to use the scale properly. [9:30] There is a popular saying that ‘muscle weighs more than fat,’ which is technically incorrect (i.e. 1 lb of margarine = 1 lb of butter) but as far as health goes, fat and muscle have different effects on physiology. [10:10] Muscle burns carbs and assists in all areas of fitness, whereas fat does not. [11:00] In my opinion, measuring inches lost (or noticing changes in how your clothing fits) is actually much more of a reliable measurement of progress than the scale. Body tape measurements are a great tool for this. [15:30] How long should it take to lose weight on keto? [15:40] Everyone’s body is different, which means the rate of weight loss is going to be different. Overall health, current body composition, activity level, and diet are some of many factors. [17:00] Initial weight loss due to water weight can cause dehydration and keto flu symptoms, so make sure to hydrate and get electrolytes! [18:10] Here’s what a few studies have shown in regard to losing weight on the ketogenic diet. [20:00] As you get closer to your goal weight, weight loss slows down. As your weight decreases, and you become a smaller person, your total daily caloric needs also decrease. This is known as metabolic adaptation or adaptive thermogenesis. - part of fat loss. Go here: Refeed and Diet Break Episode for more on adaptive thermogenesis. [21:00] Appropriate rates of weight loss on the scale and body size measurements. [23:00] Losing fat isn’t always reflected on the scale.  [23:00] Rachel’s thoughts on Exogenous Ketones? See: Episode with Ryan Lowery [24:40] Quality matters and they are not a magic weight loss or fat loss drink [25:00] Even if you read 0.2-0.4 ketones is that beneficial? Is it necessary to be above 0.5 to achieve the benefits? [26:10] Registering any level of ketones can be beneficial. Different levels may bring in different amounts of added benefits, such as mental focus and clarity. [28:00] What about people who are on keto for a while and experience elevated blood glucose levels? [28:30 ] Adaptive Glucose Sparing (aka physiological insulin resistance), in which the muscles learn to reject sugar as a fuel source.  [30:00] The Dawn Phenomenon, in which blood sugar is highest in the morning. [32:00] HOMA-IR: the homeostatic model assessment of insulin resistance, is your body maintaining its essential systems in balance or in equilibrium. What happens is insulin is working against glucose in an attempt to keep blood sugar levels stable, or in homeostasis. [33:00] Dr. Ted Naiman talks about HOMA-IR. [37:00] Rachel talks about the underrated effects of stress on blood glucose levels. [38:00] CGM and stress in this episode with Mike Mutzel [39:30] False reading on your glucose monitor may occur because of outside fragrances, dehydration, and environmental interference. Unexpected readings should be multiplied and averaged.   --- Join the FREE MetFLex Life Course: www.metflexandchill.com Rachel Gregory (@rachelgregory.cns) is a Board-Certified Nutrition Specialist, Strength and Conditioning Specialist, and Author of the best-selling book, 21-Day Ketogenic Diet Weight Loss Challenge. She received her Master’s Degree in Nutrition & Exercise Physiology from James Madison University and Bachelor’s Degree in Sports Medicine from the University of Miami. Rachel helps her clients transform their lives by starting with the physical (body), realizing the power of the mental (mindset), and ultimately gaining massive confidence that bleeds into every aspect of their lives (family, relationships, work, etc.).

Welcome to another episode of The Hormone Heartbeat Podcast! Today's episode in my fertility series is about PCOS and what it looks like for women who already have this diagnosis or they have learned from their fertility workup that PCOS may be leading to their fertility challenges. And my special guest today is Dr. Anne Hussain who is not only a PCOS "cyster" but a Naturopathic doctor with a focus on helping women navigate the complexities of PCOS and hormone health! Dr. Anne Hussain is a naturopathic doctor and period literacy advocate who helps women optimize their periods, hormones, and fertility. Her personal experience with polycystic ovarian syndrome and a thyroid disorder drives her passion to empower and educate women to practice self-awareness, self-compassion, and self-advocacy. Dr. Anne practices out of Aurora, Ontario, is a supervising clinician for the non-profit Naturopaths Without Borders - Thailand and sits on the board of directors for the Aurora Community Band and Toronto Vegetarian Association. She loves eating chocolate, drinking tea, spending time in nature, playing her saxophone, and talking about women's health. In today's episode: Dr. Anne's personal story and what lead her to do the work she does Birth control and informed choice The research involved in the diagnosis PCOS Rotterdam Criteria Insulin Resistance and testing PCOS Comorbidities Important PCOS lab tests What is a complete PCOS assessment and why it's important Homa-IR calculation and how to interpret it for women with PCOS How conception is about more than ovulation Miscarriage and how it can be thought of as a cardiovascular disease of the placenta PCOS dietary guidelines and recommendations Should women with PCOS reduce their carbs How self-compassion gets us out of guilt Top supplements for women with PCOS who are trying to conceive AMH levels as a diagnostic tool Mapping out the hormonal connection between The connection between PCOS, ovulation and appetite control Using ovulation predictor kits for women with PCOS Charting and PCOS Additional tips for fertility support and PCOS How to manage the mental-emotional aspect of PCOS What does professional help look like ***Special Gift for HHP Listeners from Dr. Anne Hussain, ND *** ---> PCOS CHECKLIST Connect with Guest: Dr. Anne Hussain, ND: Website: www.annehussain.com | Facebook: @drannehussain | Instagram: @dr.annehussain Connect with host: Dr. Antoinette Falco, ND Download your copy of Post-pill Guidebook . Website: www.antoinettefalco.com . Instagram: @drantoinettefalco Please send all inquiries and suggestions, including topics you'd like to see covered on the podcast to thehormoneheartbeatpodcast@gmail.com If you'd like to be a guest on the show and you think you'd be a good fit, please reach out!

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting or the use of Dr. Berg products. Consultants are available Monday through Friday from 8:30am to 9 pm EST. Saturday & Sunday 9 am to 5 pm EST. USA Only. Take Dr. Berg's Free Keto Mini-Course! Overview to Healthy Ketogenic Diet and Intermittent Fasting: http://bit.ly/2B61L8j http://bit.ly/2Ws2OIR http://bit.ly/2FWGIYK DATA: http://bit.ly/2ZQ2Tqq http://bit.ly/2IUIomQ Dr. Berg talks about the most important blood test which measures insulin resistance called HOMA-IR or Homeostatic Model Assessment. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. ABOUT DR. BERG: https://bit.ly/2FwSQQT DR. BERG'S STORY: https://bit.ly/2RwY5GP DR. BERG'S SHOP: https://bit.ly/2RN11yv DR. BERG'S VIDEO BLOG: https://bit.ly/2AZYyHt DR. BERG'S HEALTH COACHING TRAINING: https://bit.ly/2SZlH3o Follow us on FACEBOOK: https://www.messenger.com/t/drericberg TWITTER: https://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericberg123 Send a Message to Dr. Berg and his team: https://www.messenger.com/t/drericberg

In this episode of humanOS Radio, Dan speaks with Sander Kooijman. Sander is a post-doctoral researcher at Leiden University Medical Center, where he is investigating brown adipose tissue activation as a therapeutic target to attenuate obesity, type 2 diabetes, and atherosclerosis in humans. He and his colleagues recently published a paper examining how light exposure and environmental temperature affect measures of glucose and lipid metabolism in two large population-based European cohorts. It is well established that exposure to bright light at night is linked to metabolic perturbations. A number of studies have found positive associations between artificial light exposure in the evening and risk of type 2 diabetes. In particular, one experiment from Phyllis Zee's lab at Northwestern showed that just a single night of blue light exposure during sleep increased insulin resistance in healthy adults. But what about bright light during the day? Now that's a different story altogether. Observational evidence suggests that light exposure - particularly sun exposure - may in fact be beneficial for glucose metabolism. For example, a cohort study found that participants who received a lot of sunlight exposure during the day had a 30% lower risk of developing type 2 diabetes, compared to those who didn't get much sun. In the study discussed on this show, the researchers collected data from a combined cohort of more than 10,000 healthy middle-aged subjects enrolled in the Oxford Biobank study (OBB) and the Netherlands Epidemiology of Obesity study (NEO). Participants in these studies have provided body composition measurements (weight, body mass index, body fat percentage) as well as bloodwork (fasting glucose, insulin, fasting lipid concentrations, insulin resistance, etc). However, these studies do not assess temperature or light exposure. To capture the impact of these variables, Sander and his team very cleverly collected data on mean outdoor temperature and hours of bright sunlight (defined as global radiation >120 W/m2) from local weather stations. From this information, they were able to calculate mean outdoor temperature and bright sunlight duration during a 7-day and 30-day period before the date of blood sampling. Sure enough, increased bright sunlight exposure was found to be associated with lower fasting insulin (−1.27% per extra hour of bright sunlight), lower triglyceride levels (−1.28%), and reduced insulin resistance (HOMA-IR; −1.36%). After adjustment for bright sunlight, there was no association between outdoor temperature and measures of glucose and lipid metabolism, suggesting that it was indeed the light that was responsible here. But why? What mechanisms mediate this relationship? To find out why Sander thinks bright sunlight might enhance cardiometabolic health, and more about his fascinating work, check out the podcast!

PODCAST Ep26 - Full version of conversation with super well-researched Australian doctor Paul Mason @DrPaulMason - recorded in Boulder, Colorado. We covered: LDL-P, ApoB, Lipoprotein(a) / Lp(a), Oxidized LDL, Omega 6 Seed Oils, Gilbert's Syndrome, Antioxidants, Bilirubin, Glutathione, Carnitine versus Carnosine, Wheat Germ Agglutanin, GGT, CIMT, CAC, Glycation, Lectins, FODMAP, Magnesium, Selenium, CGM Continuous Glucose Monitors, Parkinson's Disease, and more! YOUTUBE VIDEO PODCAST HERE: https://youtu.be/pKtRa3JG-Gg TRANSCRIPT: https://thefatemperor.com/wp-content/uploads/2019/06/Dr.-Paul-Mason-Advanced-Cholesterol-Chat-and-Much-Much-More.pdf INDEX: 00:00:23 Some insights on the new cholesterol risk factor – Lipoprotein(a) or Lp(a) 00:05:10 Discussion of the role which Oxidised LDL or oxLDL has in heart disease 00:08:32 Glycation damage to LDL – a crucial part of the heart disease problem? 00:09:52 Omega 6 vegetable or seed oils add to the inflammatory cascade of destruction 00:11:17 Oxidized LDL receptors and their place in the system 00:12:33 Gilbert's Syndrome, Bilirubin and greatly reduced heart attack rates 00:14:50 Glycation, Antioxidants – Carnitine and Carnosine Distinction 00:18:27 The body's master antioxidant – Glutathione – and the Importance of GGT 00:22:08 Medical school training in nutrition – sadly lacking for doctors? 00:24:23 LDL-P, ApoB100, LDL Receptor activity – the bottom lines 00:29:24 Coronary Artery Calcification (CAC) versus Intimal Media Thickness (CIMT) 00:36:08 HbA1c and Fructosamine as risk factors 00:39:26 Continuous Glucose Monitors (CGM) and blood glucose fluctuations 00:42:05 Insulin measurements, HOMA IR and post-prandial spikes 00:45:58 CGM and problematic medications – rather fix root cause? 00:50:16 Let's look at Lectins – the taxing toxins from plant world foods 00:56:21 Parkinson's Disease and the Lectin Connection 00:59:46 Dr. Steven Gundry, poisonous beans, more lectins and the toxic ricin 01:04:27 FODMAP foods, GMO fun, WGA from wheats, lots of bad actors 01:08:07 Nuts! (and Magnesium, Selenium etc.) 01:11:20 Moving forward and emphasizing the core – Pareto-style

Graham Simpson, M.D. has been Rob Martin’s colleague for 33 years. They have worked together on numerous natural health and medicine projects. Dr. Simpson is triple board certified and he specializes in cardio-metabolic medicine. Today’s subject is Dr. Simpson’s book, the 4 Week Diabesity Cure. Among the topics is a discussion of a rarely administered test to measure insulin resistance…HOMA-IR. It’s the most important test very few patients know about…including doctors!

Neste episódio "O Doutor Saúde" nos revela 5 dicas que os exames laboratoriais nos trás dizendo se estamos envelhecendo mais rápido: RDW, leucograma, Homa IR, Ferritina e relação Triglicerídeos x HDL. Acesse a lista dos principais marcadores biológicos clikando neste link: http://seronni.com.br/lista-marcador-biologicoLink do grupo no Facebook: https://www.facebook.com/groups/doutorsaude/Cuide da sua saúde com as dicas mais atualizadas para quem quer muita informação em pouco tempo. Visite nosso site para conhecer os outros experts www.dicascurtas.com.br

Neste episódio "O Doutor Saúde" nos revela 5 dicas que os exames laboratoriais nos trás dizendo se estamos envelhecendo mais rápido: RDW, leucograma, Homa IR, Ferritina e relação Triglicerídeos x HDL. Acesse a lista dos principais marcadores biológicos clikando neste link: http://seronni.com.br/lista-marcador-biologicoLink do grupo no Facebook: https://www.facebook.com/groups/doutorsaude/Cuide da sua saúde com as dicas mais atualizadas para quem quer muita informação em pouco tempo. Visite nosso site para conhecer os outros experts www.dicascurtas.com.br

“How can I optimize my health and longevity?” “How can I live a long time and feel good doing it?” “What supplements should I take for peak performance?” “What should my ideal diet look like?” Honestly, without any data about your blood and biomarkers, you have no idea. This is because unless you know what your blood looks like under a microscope, there is no way for you to identify with 100% confidence what steps you should take to eat the right diet, to take the right supplements, to protect your health, to enhance your well-being, to perform at peak capacity, and perhaps most importantly, to live as long as possible with as high a quality of life as possible. Enter blood testing. Blood testing is the most important step you can take to identify and prevent life-threatening diseases before they happen to you. With your blood test results in hand, you can catch critical issues in your body before they manifest as heart disease, cancer, diabetes, or worse. Knowledge of exactly what is going on inside your body empowers you to implement a science-based disease-prevention program that can literally add decades of healthy years to your life. And if your goal is to not only stop disease, but to also perform at your peak physical and cognitive capacity, blood testing is absolutely crucial for identifying which diet, which supplements and which lifestyle steps you should take to optimize your specific and unique health parameters. But sadly, most annual medical check-ups that the average physician orders are simply routine, old-school blood tests that don't even test for the most important markers of disease risk, and that are simply designed to make sure you're “not dying”. They aren't designed to optimize longevity or to ensure your body is completely primed to perform at peak capacity. What most people don't realize is that you can skip your physician and simply manage the entire process for getting your blood work done yourself. And if you want to test absolutely every little thing that affects your organs, your energy, your hormones, your health and your longevity, then you've found the ultimate answer. I worked closely with WellnessFX, America's top laboratory for concierge blood testing and online access to all your blood testing results, to develop the and , which is the most complete blood testing package for men that money can buy.  This is by far the most comprehensive blood testing package I recommend and is designed for the high performer, biohacker or anti-aging enthusiast who wants access to the same type of executive health panel and screening that would normally cost tens of thousands of dollars at a longevity institute. The panel I discuss in today's podcast dives deep into overall metabolic functioning for optimal long-term health and longevity, and includes thyroid function, stress response, blood glucose regulation, sex hormone balance, heavy metals, inflammation, organs of detoxification (liver, kidneys, gallbladder, and lungs), proteins, electrolytes, blood oxygen and nutrient delivery, immune system status, vitamin D status and much, much more, including: 25-Hydroxy-Vitamin D Apolipoprotein A-1 Apolipoprotein B Blood Lead Blood Mercury Cardio IQ Lipoprotein Fractionation Ion Mobility Complete Blood Count w/ differential Complete Metabolic Panel Copper Cortisol Dehydroepiandrosterone Sulfate Ferritin, serum Fibrinogen Folate Free Fatty Acids Hemoglobin A1c Homocysteine High-sensitivity C-reactive protein IGF-1 (Growth hormone surrogate) Insulin Iron, TIBC Lipid Panel Lipoprotein (a) Luteinizing Hormone Omega 3 Fatty Acids RBC Magnesium Reverse T-3 Selenium SHBG (sex hormone binding globulin) T-3 Total T-3 Uptake T-4 (Thyroxine) T-3 Free T-4 Free Testosterone + Free Testosterone Thiamine Thyroglobulin Antibodies Thyroid Peroxidase AB TSH Uric Acid Vitamin A Vitamin B12 Zinc Estradiol As you can see, I've held nothing back and covered all bases with this customized blood panel. You will not find a test this comprehensive anywhere else, guaranteed. From identifying disease to optimizing longevity and anti-aging to maximizing performance, this test gives you absolutely everything you need. During this podcast, in which I cover my own results from my recent longevity panel, you'll discover: My own process of testing my blood. I had 19 tubes of blood drawn; you typically have 3-5 tubes drawn in a blood test. My motivation: What if you want the same type of blood test that would be tens of thousands of dollars at a longevity center? I wanted to advise myself with more precision than typical blood tests such as TSH. I designed a package with Wellness FX, for men and women. I do this on a quarterly basis; although once a year (or once per life) is sufficient for most people. First thing you see on the report: cardiovascular health. Basic lipid panel. Risk factors: Red (high caution); orange (pay attention); green (good to go). A lot of red doesn't necessarily mean a bad thing; all green doesn't necessarily mean all good either. My total cholesterol is red: 267. High cholesterol isn't a risk factor; it's when it becomes oxidized. My HDL levels are through the roof: 151. High level of HDL could mean your body is carrying a lot of metabolites to the liver due to constant inflammation. I tested all my inflammations, all very low. Question to ask: are you a lean mass hyper responder? Could have a higher LDLP particle count. High HDL, inflammation is low, not of concern. High cholesterol and high inflammation, be concerned. Below lipid panel you'll see LDL particles. I use the Thorne multivitamin. The chlorogenic acid you find in artichoke extract is efficacious in lowering APOB My peak LDL size has been climbing; ideally I want it above 222 1/2. My LDL particle count is actually low. Small low density lipoprotein low compared to peak LDL size. Overall I'm happy with my results. Look for increase in the size of my LDL particles. “How can I live a long time and feel good doing it?” Free fatty acids associated with diabetes and heart disease. Omega Index: two different fatty acids in your red blood cells. Arachidonic acid levels are normal; I feel like I could step up my Omega 6 fatty acid intake. (Sprinkle hemp seeds on your salad.) Metabolic health: Risk factors for diabetes and insulin resistance. You want your insulin levels relatively low. Wellness FX will give suggestions on how to lower insulin levels. My blood glucose level wasn't concerning, but a bit higher than normal. Homa IR score: Takes both glucose and insulin levels into account. A ratio of glucose vs. insulin. Thyroid health: You typically see only TSH. Mine has much more... My antibodies to thyroid are very low. Reverse T3 is very low; not concerned about stress. Free thyroxin index is normal. Thyroid peroxidase is a target of antibodies. I have low T3, T4, both total and free. My natural weight is 190-195; my actual weight is 175. I rarely eat until I'm full. Metabolic hormones: IGF is a bit low; I'll take colostrum for this. Cortisol: It's at 24; I want it between 2-20. If it's elevated on one snapshot, consider testing again. Cortisol metabolites. Dutch test for hormones. (link needed) Liver and Kidneys: High levels of creatinine; if you exercise prior to a lab test, the creatinine will be elevated. Blood urea nitrogen elevated. Forms when proteins break down. Elevates when people are a) dehydrated or b) exercised the day prior to the test. My liver values are of concern. ALT when elevated mildly not of concern; mine have raised each of the last 3 tests. Foods that are good for the liver. “What supplements should I take for peak performance?” Milk thistle Holy basil Dandelion root Non-alcoholic fatty liver disease. I may fall into this category. Metabolism Reset Diet by Dr. Allen Christianson (link needed) Something I do to sleep on int'l flights: an edible of marijuana. Metabolized by the liver; could have contributed to my high levels. Electrolytes Looking at Co2 and chloride levels. My Co2 has dropped. Bone health: More Vitamin D is not better; Above 80 you have increased risk of mortality. If calcium is abnormal, can be caused by abnormal albumin. The blood: You have two components of your blood: cellular (red, white, platelets) and liquid (plasma). My mean platelet volume is okay. My white blood cell count looks great. Either too little or too much can lead to mortality. Red blood cells: Look great. I spend time in the sauna which is great for blood production. My iron levels are fine. An extra steak or two per week wouldn't kill me. Floradix (link) Vitamins and minerals: Folic acid is essential for DNA synthesis. When folate is high, it could mean using a lousy multivitamin. Vitamin B12 is required for proper nerve function; mine is through the roof. Vitamin A is in perfect amount. Red blood cell magnesium the most precise way to measure magnesium in cells. Copper needed in trace amounts. Zinc important for nails, DNA synthesis, chronic disease management; too much causes bad breath, excessive sweating. Black ant extract is great for zinc. Resources from this episode: [pdf-embedder url="https://bengreenfieldfitness.com/wp-content/uploads/2018/09/Lab-Results-WellnessFX.pdf" title="Ben Greenfield Lab Results – WellnessFX"] - - - - - - - -Almsbio Glutathione with Q10 - - - - - - - - - - - - - Episode sponsors: - are the foundation of total human optimization. I highly recommend their toothpaste! Use my link and get 10% off your order. - Give the middle finger to aging. Use Kion Serum anywhere you’d like more vibrant, youthful skin and hair.   - It’s like having a personal trainer in your pocket. Inspiring music, inspiring trainers guiding your through your workout. Use my link and get 30% off a new membership. - Reclaim your inner-warrior. Have more energy. Boost your libido. Jet Pack is like a cup of coffee for your crotch. Enter code “ben” and get yourself 15% off your order at checkout. Do you have questions, thoughts or feedback for me about these lab results? Leave your comments below and I'll reply ASAP!

Several months ago, in , I commented about the book ", and said:  "I’ve just finished reading an advance copy of this book, written by my friend and former podcast guest, . At first, I figured it would be another “eggs, walnut and fish make you smarter” type of book, but instead, this manuscript took a deep, deep dive into specific genes that affect intelligence and how to pair them with food, mouthwatering recipes for everything from liver to avocado-salmon bowls, and some very good, step-by-step tips for optimizing your personal environment to enhance your cognition. It is a must read, with many pages folded over in my own copy." Max, a former podcast guest in the episode "" also created the documentary "". In the film, he explores the impact of our diets and lifestyles on brain health. Max is a also filmmaker, health and science journalist and author. He is the host of the podcast, The Genius Life. Lugavere has contributed to Medscape, Vice, Fast Company, CNN, and the Daily Beast, and appears regularly as a health and nutrition expert on the Dr. Oz Show, the Rachael Ray Show, and The Doctors. During our discussion, you'll discover: -Why a decrease in walking speed and pattern, and forgetfulness of kitchen recipes in Max's mother inspired his latest book... -Why Alzheimer's and Parkinson's disease drugs are so damaging... -The little-known but serious risks of MDMA and ecstasy... -Max's interesting perspective on dopamine and abstinence from hedonism... -Why Ben eats all the bones and cartilage and skin when he has chicken... -Why a specific population of Nigerians carry the genetic risk for Alzheimers but don't get Alzheimers... -The profound effect of ketones, fish oil and extra virgin olive oil on the brain... -How you can naturally increase blood glucose and ketones simultaneously... -The potential damage of using to much fish oil while excessively limiting omega 6 fatty acids consumption... -The actual percentage of saturated fats that you should eat... -When high HDL could be a bad thing... -Many people track blood glucose - but Max is a bigger fan of tracking Homa IR, and why that is... -A blood test that can predict Alzheimer's... -And much more... Resources from this episode: - - - - - - - - Episode Sponsors: - Stable energy, real food, no sugar crashes! Just a tasty punch of mouth-watering, chocolatey-salty-coconut goodness. - A better way to cook. Get your first 3 meals free using my link! - Get the Harry's trial set, a $13 value, for FREE when you use my link. - Use my link and get 30% off your order of the H2 tablets. And when you use code "ben" at checkout, you'll save an additional 10% off your entire order. Do you have questions, thoughts or feedback for Max or me? Leave your comments at http://bengreenfieldfitness.com/geniusfoods and one of us will reply!

Dr. Carolyn Lam:               Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center, and Duke-National University of Singapore.                                                 We know that excessive sedentary time is bad in terms of health outcomes, but does it matter how that sedentary time is accrued, whether in short or long bouts? Today's feature paper gives us some answers. More soon, right after the summary of this week's journal.                                                 The first original paper in this week's journal provides insights into the mechanisms underlying neointima formation in arterial restenosis. Co-first authors, Dr. Cheng and Shi, corresponding author Dr. Li from Wuhan University in China, and their colleagues, performed an elegant series of experiments in which they demonstrated that interferon regulatory factor 4, or IRF4, which is a member of a family of key, innate, immune regulators known to play a role in cardiometabolic disease, actually protects arteries against neointima formation.                                                 They further probed the mechanism underlying this protective effect and found that IRF4 promoted the expression of Krüppel-like factor 4 by directly binding to its promoter. Genetic over-expression of Krüppel-like factor 4 in smooth muscle cells reversed the neointima promoting effect of IRF4 ablation. Whereas, ablation of Krüppel-like factor 4 abolished the protective function of IRF4, thus indicating that the protective effects of IRF4 against neointima formation were Krüppel-like factor 4 dependent.                                                 These findings suggest that the previously undiscovered IRF4 Krüppel-like factor 4 axis plays an important role in vascular proliferative pathology and thus may be a promising therapeutic target for the treatment of arterial restenosis.                                                 The next paper highlights that high-spacial resolution in gene expression signatures can reveal new regulators, genetic pathways, and transcription factors that are active in well-defined regions of the heart.                                                 Now we know that traditional genome-wide transcriptome analysis has been disadvantaged by the fact that the signals are derived from tissue homogenates. Thus, the authors of this current paper, including Co-First authors Dr. Lacraz and Junker, corresponding author Dr. Van Rooij from University Medical Center Utrecht in the Netherlands used tomo-seq to obtain genome-wide gene expression signature with a high spacial resolution, spanning from the infarcted area to the remote areas to identify new regulators of cardiac remodeling.                                                 Using this technique, they identified SOX9 as a potent regulator of cardiac fibrosis. In vivo loss of SOX9 reduced the expression of many extracellular matrix genes, which coincided with a blended cardiac fibrotic response upon ischemic injury.                                                 These data therefore were able to unveil currently unknown relevance of SOX9 as a key regulator of cardiac fibrosis, thus underscoring that tomo-seq can be used to increase our mechanistic insights into cardiac remodeling, and to help guide the identification of novel therapeutic candidates.                                                 The next paper reports the primary results of the effect of ferric carboxymaltose on exercise capacity in patients with iron deficiency and chronic heart failure, or EFFECT-HF study, which is a randomized control trial of intravenous ferric carboxymaltose, compared to standard of care on the primary end point of change in peak Vo2 from baseline, to 24 weeks in patients with symptomatic, chronic heart failure with reduced ejection fraction and iron deficiency.                                                 In this report from Dr. van Veldhuisen from University Medical Center Groningen and colleagues, intravenous ferric carboxymaltose was shown to significantly increase serum ferritin and transferrin saturation. At 24 weeks, peak Vo2 had decreased in the control group, but was maintained in the group receiving intravenous ferric carboxymaltose.                                                 Although a favorable effect on peak Vo2 was observed with ferric carboxymaltose, compared to standard of care in the primary analysis, this effect was highly sensitive to the imputation strategy for peak Vo2 among patients who died.                                                 They also reported that patient's global assessment and functional class, as assessed by New York Heart Association, improved on ferric carboxymaltose compared to standard of care.                                                 Whether ferric carboxymaltose is associated with an improved outcome in these high risk patients, deserves further study.                                                 The final study provides important long term clinical data to guide lead management decisions in patients with cardiac implantable electronic devices.                                                 Dr. Pokorney from Duke University Medical Center in Durham, North Carolina, and colleagues, analyzed over 6,000 Medicare patients and found that device extraction was associated with a lower adjusted five year infection rate, compared with a cap and abandon strategy. There was a lower absolute five year mortality with extraction, but after adjustment there was no association between extraction and a lower five year mortality.                                                 In summary, therefore, elective lead extraction for non-infectious indications in this Medicare cohort had similar long term survival, but lower risk of device infections at five years, compared to capping and abandoning leads.                                                 Patient and provider preferences are critical to decision making when considering extraction versus capping and abandonment of leads.                                                 Well, that wraps it up for your summaries. Now for our feature discussion.                                                 For today's feature discussion, we are talking about sedentary time and a metabolic risk of having too much of it. But, today's paper is so interesting because it tells us that it's not just the total amount of sedentary time that may matter, but how we accrue the sedentary time. Very, very novel concept in my point of view and I'm so pleased to have the first and corresponding author of this paper, Dr. Keith Diaz from Columbia University Medical Center with us, as well as Associate Editor from Johns Hopkins, Dr. Wendy Post.                                                 So pleased to have you both. Keith, could we just dive right into it? Tell us what population you were looking at, and what you found. Dr. Keith Diaz:                    Sure, so we were studying a population of participants enrolled in the Hispanic Community Health Study, so it's a US populations of over 16,000 Hispanic adults. And essentially what we found was that sitting for prolonged bouts, so sitting for one, two hours at a time, was associated with poor glucose regulation. Dr. Carolyn Lam:               Well, yikes. I've actually been sitting for a few hours in a row right now, actually. I think these results are phenomenal, but could you maybe expand a little bit on the details, like how long is too long? And, how often a break needs to happen for you to see differences in the metabolic risk? Dr. Keith Diaz:                    It's a good question and, to be honest, we don't know. I think that's where the research needs to head, but right now it seems to be that taking a break every 30 to 60 minutes could be beneficial. I think that's what we've found thus far. Dr. Wendy Post:               Keith, we were really excited to get your paper in. I think everyone on the Associate Editorial Board was especially interested in it because we can all relate. As Carolyn said, she's been sitting for a long time and when we have these meetings we have two hour meetings at a time and maybe we need to start saying that in the middle we should all stand up and take a break. So we can all relate to this.                                                 But I think one the biggest questions that we had related to data itself, was the association between the total sedentary time and the sedentary bout duration. Maybe you can tell us a little bit more about those correlations in the interaction and tell us also how you also measure sedentary bout duration and total sedentary time in this observational cohort. Dr. Keith Diaz:                    Sure, so I'll start with that latter question. So, we measured sedentary time [inaudible 00:09:32] subjectively. So we actually used an activity monitor called an accelerometer to see how sedentary they are. And how we quantified sedentary bouts is we just looked at how long consecutively a person sat without moving. That was considered sedentary bout. In terms of correlation, what we found is that there are very closely linked. So, people who sit for long hours during the day for total volume, also sit in long bouts. And so what we wanted to do was try to figure out and piece apart, which one is more important? When we're trying to ... If we're thinking about guidelines and what we should be doing about our sedentary time, is it important to reduce our volume or interrupt our bouts? And so what we found is that they're not independent, and that they're in many ways synergistic. And that the association of prolonged sedentary bouts with glycemic biomarkers varied according to how much total volume you sit and vice-versa. Dr. Wendy Post:               Can you expand a little bit more on that? So tell us about the interaction that you found between sedentary bout duration and total sedentary time. Dr. Keith Diaz:                    Sure, so we did find that there was a specifically significant interaction between the two variables and so what we tried to do is actually categorize people as to whether they were high for both characteristics or high for just one of them. And so what we found was that those participants who are high for both, so they had high volume and sat in long bouts, they had the worst glucose regulation, and that those individuals that were high for just one of the characteristics had a little bit better glucose regulation. And so really what we thought the take home message was when thinking about how do we improve our sedentary behaviors is that it's targeting both. It's not sitting for large volumes during the day, but also making sure to take frequent breaks every 30 or 60 minutes. Dr. Wendy Post:               And tell us about the glucose measures that you included in your study. Dr. Keith Diaz:                    Yep, we had a couple glucose measures. One we had people do a two hour glucose tolerance test, so they took a glucose drink and then we measured their blood sugar levels two hours after having that drink. We also measured their H1Ac levels as well as their fasting glucose and fast to link insulin measures from which we can then derive measures of something called HOMA IR, which is a measure of insulin resistance. Dr. Wendy Post:               And the associations that you saw were primarily with the HOMO IR and the two hour glucose levels but less with the hemoglobin A1c? Dr. Keith Diaz:                    Correct. Dr. Wendy Post:               So it really appears to be that insulin resistance that's most affected by the total sedentary time and sedentary bout duration. Tell us about potential confounders and how you factored that into your analysis. Dr. Keith Diaz:                    Yeah, there was quite a number of potential confounders between this relationship of sedentary behavior and glycemic biomarkers. One of them in particular that we were concerned about most were things like body mass index or exercise or physical activity levels. And so we took a look at what we adjusted for those confounders how the relationship changed. And what we did find was that there was an attenuation and association between sedentary behavior and the glucose markers, but there was also ... were still statistically significant. So suggestive that maybe they're partly in the pathway of body mass index or exercise but they didn't make the relationship go away. I should add that we looked at a couple other confounders, we looked at things like inflammation, C-reactive protein, as well as whole bunch of other measures of cardiovascular risk factors. I'll stop there. Dr. Wendy Post:               And what about the fact that study is cross-sectional, are there any caveats related to the study design that you'd like to point out to the audience? Dr. Keith Diaz:                    Yeah, I think that's an important point, that this is cross-sectional, so by no means can we infer causality that sedentary behavior causes glucose dysregulation, it's just purely an association. So I think anyone listening to this podcast should keep that in mind when reading this paper or listening to this podcast. Dr. Wendy Post:               So if you were writing the next set of guidelines what would you recommend in terms of how you implement these findings into guidelines? Not to imply that we think that these cross-sectional observational data mean that we're ready to change guidelines but, if these were replicated in randomized trial or some other more objective data study design, how do you think we should use these results to change our behaviors? Dr. Keith Diaz:                    I think these guidelines point ... or, with the current guidelines are, sit less, move more, where the guidelines that came out from AHA in October of 2016. In part, they were not as specific because we don't have quite the quality of guidelines or data that we need for more qualitative guidelines, or quantitative guidelines. I think if we're able to replicate these data with [inaudible 00:14:10] or point us towards at least is, also, that we should be interrupting our sedentary bouts. And so what I'd like to see hopefully if we can replicate something I'd like guidelines that say every 30 minutes or every 60 minutes of sitting you should stand up and move. And hopefully with future studies that are coming out that we can make them even more specific and something along the lines of every 30, 60 minutes you stand up and walk for 5 minutes or you just stand up for 1 minute. That's where I'd like to see the science head and I think this study points us in the that direction of maybe we have to start thinking about breaking up our sedentary bouts. Dr. Carolyn Lam:               All right you guys, I don't know about you, but I am literally standing up right now while I'm listening to you both. This is so interesting and I love the way, Wendy, you reflected the robust discussions we had as team when we were working through this paper. Congratulations again, Keith, for just this remarkable paper. Actually, maybe I could just ask, Wendy, what do you think? What do you think our next steps that may need to get these kinds of recommendations, perhaps into guidelines? Dr. Wendy Post:               I think as was alluded to before, these are observational data so they're important for hypothesis generation, but really to have evidence that would lead to changes in guidelines maybe having a randomized trial, where obviously you can't have very hard outcomes, but randomized trials of some duration that could potentially lead to changes and important outcomes, would then maybe lead to changes in guidelines. But there isn't anything that we would lose from trying to implement these kinds of behavior, changes into our lifestyle since the downside and the risk is pretty low. So even if they don't make the strongest level of evidence at this point, I think we can still all be mindful of this and so.                                                 One thing that we've been trying to do in our preventive cardiology group at Hopkins is trying to implement walking meetings. In fact, I just had an email discussion with one of my colleagues about meeting tomorrow and she said, "Well, where do you want to meet?" And I said, "Well, why don't we go for a walk? The weather should be nice." And so I think if we're all mindful of trying to, not only increase our amount of physical activity, but trying to limit the sedentary bout duration by being creative and trying to change, sort of, long standing traditions of having meetings sitting in an office, then that could be helpful.                                                 So, just something for our audience to think about as well. Dr. Carolyn Lam:               That's brilliant. You know, the one thing that I was thinking, though, just thinking about the reception of these data in my country, in where I practice, in Asia. This was a purely Hispanic or Latino population. I suppose there is a perception that that population may be predisposed to cardiometabolic disease and so on, and so you know, what's the applicability to us in Asia? So, I'm really happy, particularly to hear how you've taken it on. I mean, it's a simple thing, why not, right? Just to be more active. There's surely can't be something wrong with that. What do you think of that? Dr. Wendy Post:               Totally, I think it's important to emphasize the unique nature of these data and that they come from a Hispanic study, which is a really important addition to our literature in epidemiology and cardiovascular disease and certainly there are significant differences in lifestyle among different communities within the United States and across the globe, as you've experienced having lived in different countries. And so, I think we need obtain more data about how there might be differences based on various traditions and different lifestyles, and try to target those who are at greatest risk. Dr. Carolyn Lam:               Keith, did you have anything to add to that? Dr. Keith Diaz:                    Yeah, I think Wendy is right on and certainly I don't think we have any reason to suspect that sedentary behavior acting differently in Hispanics versus other populations, and so I still think going forth with this notion that we all should be reducing our sedentary behaviors is important to highlight. Dr. Carolyn Lam:               Fantastic. Well, thank you both for a really wonderful discussion. This is really cool, I think a lot of people will be talking about this.                                                 Listeners, you've heard it first, though, in Circulation on the Run. Thank you for joining us today and don't forget to tune in next week.