measure of average lifespan in a given population
POPULARITY
Vitamin K2 (MK-7) and Coronary Artery Calcification: Insights from a 2-Year Trial: Nutritionist Leyla Muedin discusses a two-year randomized clinical trial in JAMA Cardiology from Maastricht University Medical Center reporting that daily vitamin K2 (menaquinone-7, MK-7) at 360 mcg slowed progression of coronary artery calcification (CAC) in 180 patients with confirmed atherosclerotic cardiovascular disease and baseline CAC 50–400 Agatston units. Compared with placebo, consistent MK-7 use was associated with 29% lower CAC progression and 42% less arterial calcium mass progression, though CAC still increased in both groups; stenosis increases were numerically lower with MK-7 but not statistically significant. Leyla notes many participants were on statins and were smokers, highlighting that statins can raise CAC by stabilizing soft plaque via calcification. The trial suggests MK-7 may slow calcification in newer plaques, may improve arterial elasticity via matrix GLA protein activation, is inexpensive and safe, but clinical event reduction remains unproven; Leyla suggests considering MK-7 (possibly 360 mcg) with vitamin D, magnesium, and dietary measures.
I'm 78 and had a hysterectomy. Is it safe for me to eat tofu or other soy foods?Mitopure joins L'Oreal to create a face cream with Urolithin A.Does taking hyaluronic acid orally cause water retention?Can you discuss ETA contained in New Zealand green mussels?What are your thoughts on using vibration devices to help osteoporosis?
World Cup!What did humans eat from the Ice Age to the Bronze Age?What supplements should I avoid while undergoing radiation therapy for prostate cancer?What is the treatment for sarcoidosis of the lung? Both my friend and his wife have it.
Dr. Hoffman continues his conversation with Nathan Jones, founder and CEO of Xlear, Inc.
Nathan Jones, founder and CEO of Xlear, Inc., reveals xylitol's role in supporting oral and nasal “gateway” microbiomes by selectively starving acid-producing Strep mutans rather than indiscriminately killing bacteria, and warns that harsh mouthwashes can disrupt beneficial oral bacteria linked to nitric oxide production and possibly blood pressure. Jones outlines Spry and Xlear products (gum, mints, toothpaste, mouthwash, dry-mouth “Rain,” and upcoming gummy candies, a new dental probiotic with added nutrients, and a direct-to-consumer oral bacteria test kit with pre/post tracking). He discusses diet, emphasizing sugar as a key driver of cavities and criticizing limited focus on sugar in a Surgeon General oral health report. In part two, Jones describes ongoing and planned legal actions against the FTC over shifting evidentiary standards and reputational damage, then reviews Xlear's allergy and respiratory approach via nasal hygiene, product tiers (regular, Max with quercetin, Rescue botanicals, and a decongestant), and a forthcoming ectoine-based spray to support mucus barrier integrity.
Dr. Hoffman continues his conversation with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health.
Nitric Oxide Explained: Vascular Health, Exercise Performance, and N1o1 with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He details NO as a ubiquitous messenger affecting blood flow, erectile function, cognition, exercise performance, endothelial dysfunction, and aging-related declines in NO production. Bryan explains why PDE5 inhibitors like Viagra prolong cyclic GMP signaling but don't fix NO deficiency, and why beet products often fail due to variable nitrate content and inadequate dosing. He outlines his NO lozenge approach that generates NO gas from sodium nitrite and magnesium ascorbate, plus a fermented beet powder drink (NOBeets), and emphasizes the role of oral bacteria (and harms of antiseptic mouthwash/fluoride) in nitrate conversion. They review published endpoints, including flow-mediated dilation, blood pressure effects, inflammation markers, triglycerides, stem cells, plaque regression, applications to Alzheimer's, glaucoma/microvascular disease, safety/dosing considerations, risks of arginine supplementation, and a dual-chamber topical NO serum developed from wound-healing experience.
Fourth week of June, what'd you miss in vet med?Anterra Capital closes $100M Fund IIIElanco launches VC armMerck backs Rejuvenate BioRoyal Canin researchers call for actionHeart+Paw Personalized Care PlansPayPal Ventures closes shopHelpful links:The Bird Bath substackPasspaw - Pet Travel Compliance Tools For Veterinary PracticesThe Bird Bath Terminal
Why aren't there more medical insurance plans that cover alternative medicine? Solutions for Long Covid; MK7 vitamin K slows arterial calcification; Keto diet shows promise for treatment of anorexia; It's not so much salt restriction—it's the dietary sodium/potassium ratio in hypertension; Study finds multivitamins don't keep you from getting Covid—but when you get it, it's milder; Incidence of social anxiety disorder is soaring among young people.
Should you stop taking glucosamine based on a new study linking it to Alzheimer's? What's behind the spate of “Tai Chi Walking” social media posts? Undereye “festoons”—what to do about them? Are antibiotics the only treatment for SIBO? Vaping after smoking hikes risk for lung cancer.
There's a difference between how long you live and how well you live. And watching someone you love lose their health changes everything about how you see that gap. I am reposting this episode of Your Journey to Joy Podcast. I get personal. I recorded this one on my dad's 92nd birthday — and if you've ever watched a parent's health decline, you know exactly the mix of emotions that comes with that.
In this Father's Day episode, Dr. Bud Marr hosts solo while co-host Bo Bonner travels through Europe, welcoming back an Uncommon Good "all-star": Joe Stopulos, host of the Man Up show on Iowa Catholic Radio. Both shows launched in 2016, and this episode marks an Iowa Catholic Radio mashup centered on one question — what does it mean to live a life well lived in light of eternity? The conversation grows out of Joe's recent loss of his father, who died after a fourteen-week battle with aggressive cancer. Joe shares the beauty found within that suffering: a death surrounded by family, the reception of communion and the sacrament of anointing, and a final afternoon of praying the Rosary and the Chaplet of Divine Mercy at his father's bedside. The discussion turns to the Church's teaching that we should never hasten death, and how that teaching preserved precious conversations, graces, and "teachable moments" that would otherwise have been lost. Highlights and themes include: The witness of service over selfishness — drawing on Joe's father, bookstore owner Lois Brookhart, Father Aquinas, and Blessed Pier Giorgio Frassati as everyday and saintly models Bishop Robert Barron's challenge that "your life is not about you" Memento mori and Ben Sasse's reflections on facing mortality Living the joy of the gospel without needing to be a scholar or apologist — the "little way" of St. Thérèse and the humble witness of Blessed Solanus Casey and St. John Henry Newman Balancing vocation, career, and intentional time with children Health span and stewardship of the body — referencing Peter Attia's Outlive — as a way to keep serving others well into old age Tim Carney's Family Unfriendly and resisting the "Instagram" sheen of family life The Uncommon Good is a production of Iowa Catholic Radio, exploring Catholic social teaching for everyday life. Thank you to Imogene Ingredients for helping to underwrite the show — learn more at imogeneingredients.com. Pray with us on air: the Rosary at 4:30 AM, 8:30 AM, 10:00 AM, and 2:57 PM, and the Chaplet of Divine Mercy and Rosary at 8:30 PM. You can also pray the Rosary anytime on the Iowa Catholic Radio app, available 24/7/365, and find upcoming diocesan events on our events page. We covet your time, talent, and treasure — there are opportunities throughout the year to volunteer and support the mission. Learn more at IowaCatholicRadio.com. #TheUncommonGood #IowaCatholicRadio #CatholicPodcast #Catholic #Catholicism #FathersDay #ALifeWellLived #MementoMori #DyingWell #Fatherhood #CatholicMen #ManUpShow #BishopBarron #JoyOfTheGospel #Frassati #SolanusCasey #JohnHenryNewman #CatholicSocialTeaching #FaithAndFamily #EndOfLifeCare #CatholicFaith #LiveInLightOfEternity #Healthspan #Outlive Iowa Catholic Radio Network Shows:Be Not Afraid with Fr. Fabian Moncada and Fr. Bruce RiebeBe Not Afraid in Spanish with Fr. Fabian MoncadaCatholic Women Now with Chris Magruder and Julie NelsonMaking It Personal with Bishop William JoensenMan Up! with Joe StopulosSunday Dive with Katie PatrizioThe Catholic Morning Show with Dr. Bo BonnerThe Daily Gospel Reflection with Fr. Nick SmithThe Uncommon Good with Bo Bonner and Dr. Bud MarrFaith and Family Finance with Gregory WaddleWant to support your favorite show? Click Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Smart Fitness and Food Radio | Ernährung, Training, Lebensmittel, Abnehmen, Muskelaufbau, Gesundheit
Diese Podcastfolge ist der zweite Teil unserer Roundtable-Session mit dem amerikanischen Bodybuilder, Buchautor und Dozenten Scott Stevenson sowie Stammgast Valentino Peluso. Diesmal steigen wir tief ins Thema ein, das immer mehr Menschen beschäftigt, je älter sie werden: Langlebigkeit. Nicht nur länger, sondern vor allen Dingen besser und fitter leben. Ihr erfahrt unter anderem: Warum wer konsequent Kraft- und Ausdauertraining kombiniert, körperlich bis zu 20 bis 30 Jahre jünger sein kann als der Altersdurchschnitt. Weshalb Greifkraft und VO2max zu den aussagekräftigsten Gesundheitsmarkern gehören, die wir haben. Was 90-Jährige in einer bekannten Studie durch simples Beinstrecker-Training zurückgewonnen haben, und warum das ein selbst verstärkender Prozess ist. Warum Krafttraining im Alter wichtiger wird als Ausdauer, und wie man beides sinnvoll kombiniert. Welche Rolle soziale Bindungen für die Langlebigkeit spielen, und warum das für Kraftsportler oft unterschätzt wird. Und schließlich die Frage, ab wann Longevity-Optimierung zu extrem wird, und wie man die gesunde Mitte zwischen maximalem Healthspan und echtem Lebensgenuss findet. Diese Folge ist der zweite Teil einer Doppelfolge. Den ersten Teil mit den Themen Diet Breaks, Recovery und Periodisierung findest du in der vorherigen Episode. Enjoy! Supplements: ► Maximal mögliche Rabatte mit dem Code "SMARTFITNESS" auf alle Supplements von www.esn.com & www.morenutrition.de und Kleidung von www.oace.de! Vielen Dank für den Support :-) Direkte Link zu meinen Social Media-Kanälen auf: ► Instagram ► YouTube ► TikTok ► Facebook Wenn dir die Show gefällt, dann schreib mit doch bitte eine Bewertung auf iTunes und abonniere die Show :) Hast du Ideen, Fragen oder Anregungen? Dann schreib mir einfach an info@smartfitnessandfood.de Hier findest du alle Links zu Scott: Instagram: https://www.instagram.com/fortitude_training/ Facebook: https://www.facebook.com/scott.stevenson.1884 Homepage: http://drscottstevenson.com/index.html Buch von Scott: https://www.amazon.com/Your-Own-Bodybuilding-Coach-Year-Round/dp/0990471810 Hier findet ihr alle Links zu Valentino: ► Hier geht's zum Instagramaccount von Valentino ► Hier geht's zur Homepage von Valentino ► YouTube Kanal von Valentino Wenn dir die Show gefällt, dann schreib mit doch bitte eine Bewertung auf iTunes und abonniere die Show :) Hast du Ideen, Fragen oder Anregungen? Dann schreib mir einfach an info@smartfitnessandfood.de
Sleep, Glymphatic Detox, and the Hidden Heart Risks of Sleep Apnea: Nutritionist Leyla Muedin explains how sleep supports brain “housekeeping” via the glymphatic system, a glial-lymphatic waste-clearance network most active during sleep that moves cerebrospinal fluid through brain spaces to remove metabolites and toxic proteins such as amyloid beta, with sleep deprivation linked to amyloid accumulation. She notes other clearance pathways, including meningeal lymphatic vessels, whose impaired function is associated with neurodegenerative disease and brain injury. Reviews of human studies suggest sleep influences glymphatic outcomes, though results are inconsistent and methods vary. She emphasizes that poor sleep is associated with dementia risk, depressive symptoms, cardiovascular events, mortality, and impaired glucose metabolism, and highlights lifestyle strategies that may improve sleep. She warns that untreated obstructive sleep apnea accelerates cardiovascular aging via intermittent hypoxia and inflammation, raising blood pressure and cardiovascular event risk, while treatment (e.g., CPAP) may halt or reverse damage.
What is still possible in midlife?Many of us reach our forties, fifties and sixties assuming that the major chapters of our lives have already been written. Careers are established, habits are set, and the opportunity for significant change may feel increasingly limited.Jeffrey Weiss challenges that assumption.At the age of 48, he ran his first 10-kilometre race. In the years that followed, he completed Ironman Arizona twice, finished a 72-mile ultramarathon, and embarked on a successful new chapter in his professional life that culminated in a multi-billion-dollar startup exit.In this conversation, we explore the power of healthspan, the value of audacious goals, how fitness can transform both body and mindset, and why it's never too late to embrace a new challenge.Jeffrey is the author of Racing Against Time: On Ironman, Ultramarathons, and the Quest for Transformation in Mid-Life.EnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountPartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
In this episode, Dr. Thomas Hemingway shares one of the Top Longevity Killers, Inflammaging, what it is and what you can do about it.He explains how you can reverse this and get your body, health and life back, so you aren't just defined by how many candles are on the birthday cake, but by how you feel-- younger, stronger, and sharper than before.Have a Listen and Share with a Friend!**Free PDF: "How to Optimize your Metabolism in 7 Easy Steps." Inside the PDF, we pull back the curtain on how to actually get your metabolism Super-charger and running better than ever before.*And, in my new Performance, and Longevity medical practice we specialize in turning back your biological age and OPTIMIZING HORMONES so you can feel a decade or more younger so you can do the things you want to do that you thought were no longer possible due to your age. Join the waitlist here!*Don't wait to Prioritize your health, Start Today with the Simple and Powerful Steps detailed in my Best-selling book, PREVENTABLE.*ACCESS my FREE workshop, "GET 10 Years Younger, Stronger, and Sharper" How to turn back your biological age 10-20 years so you can do the things you want to do that you no longer thought possible due to your age. Perform at your best and live your best life!Join my Free Masterclass on Midlife Hormones, "Why You Don't Feel like Yourself anymore and What to Do about it!"JET LAG Survival Guide. Free PDF!*GET DIRECT ACCESS to DR. HEMINGWAY in these AMAZING COURSES!**Free Resource: "The 7 lab tests your doctor likely is not checking and could be the key to why you don't feel your best." *Don't Forget to SHARE with a Friend and please drop a Review:) It means the world!Mahalo and Aloha andTo your health,
What may be the real driver of persistent musculoskeletal pain in menopause?What are your thoughts on hyperbaric oxygen for treating hard-to-heal wounds?Kudos to holistic veterinarians!My prostate is Swiss cheese now after so many biopsiesWhat's the latest on melatonin?
Is there any truth to some of the latest news that claims glucosamine supplements accelerate dementia and Alzheimer's?Some key points on methodology - what were they actually measuring?What does glucosamine have to do with hyperglycosylation?
Send us Fan MailThe Quiet Power of Legumes.What if the secret to a longer, healthier life isn't trendy, expensive, or Instagram-worthy — it's sitting in a can in your pantry right now? Today, I break down why legumes show up again and again in the diets of the world's longest-living people, and how to add them to your plate without overhauling your life.Calls to Action• Rate and subscribe to Project Weight Loss• Share this episode with someone who needs a gentle nudge toward sustainable habits• Try one of the three legume swaps this week and tag the showCitations & SourcesDarmadi-Blackberry, I., Wahlqvist, M. L., Kouris-Blazos, A., Steen, B., Lukito, W., Horie, Y., & Horie, K. (2004). Legumes: the most important dietary predictor of survival in older people of different ethnicities. Asia Pacific Journal of Clinical Nutrition, 13(2), 217–220.Buettner, D., & Skemp, S. (2016). Blue Zones: Lessons From the World's Longest Lived. American Journal of Lifestyle Medicine, 10(5), 318–321.Stanley, E. (Lord Derby). "Those who think they have no time for healthy eating will sooner or later have to find time for illness." (Widely attributed quote, often cited in health and wellness literature.)DisclaimerThis podcast is for informational and educational purposes only and is not intended as medical advice. Listeners with specific health conditions or dietary needs should consult their healthcare provider or a registered dietitian.Let's go, let's get it done.Get more information at: http://projectweightloss.org
In today's episode, AgingIN CEO Susan Ryan welcomes neuroscientist, audiologist, and educator Kelly Tremblay, PhD, for a conversation about healthy aging, brain health, and the science behind longevity. Susan and Dr. Kelly also preview the upcoming AgingIN Conference 2026 and its highly anticipated Longevity Summit, where participants will explore the importance of knowing the difference between lifespan and healthspan. Dr. Kelly explains how the World Health Organization Integrated Care for Older People (ICOPE) framework offers a practical roadmap for supporting older adults through a holistic focus on mobility, cognition, communication, mental well-being, and meaningful participation in daily life. The conversation also highlights emerging technologies, community-based solutions, leadership lessons, and the importance of breaking down silos to create an ecosystem that supports people as they age. Learn about the AgingINnovation 2026 annual conference here: https://aginginnovationconference.org
Dr. Hoffman continues his conversation with pediatrician and author Dr. Elizabeth Mumper.
Pandemic Policies, Vaccines, and Harms to Children: pediatrician and author Dr. Elizabeth Mumper discusses her book “Kids and COVID: Costly Mistakes That Must Never Happen Again.” Mumper argues parents should question authorities, citing early pandemic decisions such as lockdowns, masking, and a “one size fits all” vaccine strategy despite children's low risk from COVID. She supports the Great Barrington Declaration's focus on protecting high-risk groups and criticizes suppression of repurposed treatments like hydroxychloroquine and ivermectin. The discussion raises concerns about mRNA vaccine safety, biodistribution of lipid nanoparticles, underreporting to VAERS, loss of long-term control groups, myocarditis risk in young males, and claims of severe neurologic effects and “turbo cancers.” Mumper describes developmental, educational, and mental-health harms from masking and school closures, challenges vaccine mandates as violating informed consent, explains the cell danger response concept, and criticizes Paxlovid while favoring integrative approaches.
Dealing with the Latest Financial Trend: Spending Your Kids' Inheritance Episode 388 – Financial trends come and go, but the latest, “SKI,” or Spending Kids' Inheritance, is likely to have a lasting impact. Are you prepared? There are some ways to learn how to “SKI” without getting hurt. More SML Planning Minute Podcast Episodes Transcript of Podcast Episode 388 Hello, this is Bill Rainaldi, with another edition of Security Mutual's SML Planning Minute. In today's episode, dealing with the latest financial trend: spending your kids' inheritance. Have you heard of the latest movement in personal finance? It's called “SKI,” or “Spending Kids' Inheritance.” Not surprisingly, it can create conflict across generations. It wasn't that long ago that people commonly followed the same financial plan: save money during your high earning years, spend carefully during retirement, and leave a decent inheritance for your kids so that they can live a better life than you did. But according to a recent article in Kiplinger, those plans are changing. Rather than focusing on what they'll eventually leave behind, more people are trying to spend their money while they’re still here to enjoy it. Today, new retirees are spending more on experiences, including “bucket list” travel.[1] In many ways, it's simply recognizing that your health, longevity and energy levels are going to run out someday, and maybe it's best to experience some fun while you still have the chance. And it's having an effect on the travel industry. The trend has become noticeable enough that it's “beginning to reshape how affluent travelers are spending their money on luxury travel.”[2] It's understandable why this is happening. As we've documented in previous episodes, longevity is on the rise. But there's also evidence to suggest that healthspans aren't keeping up. Healthspan can be defined as the number of years a person lives a “healthy, active, disease-free life.”[3] Research by the World Health Organization indicates that there's a growing disparity between lifespan and healthspan. The average gap between lifespan and healthspan is estimated at approximately 12.5 years in the United States, which is 13 percent higher than it was in the year 2000. In other words, over time, people are gaining extra years of life faster than they are gaining years of good health.[4] Perhaps one other reason for the upswing in SKI is that a surprising number of heirs end up wasting their inheritance. According to a recent survey by Texas Tech University and the University of Alabama, a substantial portion of heirs spend all of their inheritance in the first year. By then, a full 42 percent had seen their net worth drop back to or below what it had been before the inheritance.[5] As one of the authors wrote, “This propensity to immediately spend the entire inheritance is high. In fact, it's higher than with ANY OTHER type of financial windfall (when controlling for windfall size).” There are certainly some risks built into the SKI trend. For one thing, if you're not careful, you could easily spend your own retirement savings too quickly and be forced to adjust to a lower standard of living. And so many people underestimate the eventual cost of health care and long-term care. Also, it's easy to let small upgrades in your lifestyle add up to a much bigger problem later on, a phenomenon known as “lifestyle creep.” Kiplinger goes on to suggest some ideas for how to SKI intelligently. First, you need to set a baseline. Not for what you want to spend, but for what you want to keep. This should help maintain some peace of mind for both you and your heirs.[6] Next, they suggest doing some extra budgeting when it comes to travel. Make travel a specific factor in your overall retirement plan. The author also feels that a bucket list trip doesn't have to be to an exotic place on the other side of the world. It just has to be meaningful. In the long run, a memorable shared experience while you're living can have a greater impact than a bigger inheritance.[7] And finally, maybe you can still make some gifts to your heirs from time to time. The belief is that a smaller financial gift, at the right time, can have an oversized impact. So can bringing some of your heirs along with you on some of your trips. The memory might end up being more important than the money.[8] An important question remains, however: how to deal with SKI? There's one potential solution they fail to mention: life insurance. It's there to provide that extra cushion. If you've got enough of it, you can feel free to spend a good chunk of your kids' inheritance without much guilt. It's as if you've addressed the inheritance part prior to your retirement spending. Purchasing life insurance, and early, can be one of those instances where you really can get the best of both worlds during your working years and in retirement. And as you probably realize, the older you get, the higher life insurance premiums become. So, the sooner you start, the better. Do you have enough life insurance that your heirs will be OK if you decide to go “Skiing?” Your Security Mutual Life insurance agent can help. Your Security Mutual Life insurance agent will augment or assemble your team and coordinate with your attorney and tax professional to review your situation and to determine the insurance plan that will best suit your needs and objectives. [1] Maddox, Choncé. “The SKI Travel Trend Is Reshaping Retirement Spending.” Kiplinger.com. https://www.kiplinger.com/personal-finance/travel/ski-retirement-travel-trend (accessed April 28, 2026). [2] Kompanik, Noreen. “The SKI trend that's reshaping travel.” GMtoday.com. https://www.gmtoday.com/travel/the-ski-trend-that-s-reshaping-travel/article_07ca7b72-0eb4-43fc-b8ec-e69fef82a694.html (accessed April 29, 2026). [3] Buckles, Susan. “The global divide between longer life and good health.” Mayoclinic.org. https://newsnetwork.mayoclinic.org/discussion/the-global-divide-between-longer-life-and-good-health/ (accessed April 28, 2026). [4] Borst, Heidi. “Longevity In The U.S.: The Gap Between Lifespan and Health Span.” Forbes.com. https://www.forbes.com/health/wellness/longevity-life-expectancy/ (accessed April 28, 2026). [5] Brin, Dinah Wisenberg. “Heirs Beware: 42% Spend Inheritance Within a Year, Study Finds.” Thinkadvisor.com. https://www.thinkadvisor.com/2026/04/07/heirs-beware-42-spend-inheritance-within-a-year-study-finds/ (accessed April 28, 2026). [6] Maddox, Choncé. “The SKI Travel Trend Is Reshaping Retirement Spending.” Kiplinger.com. https://www.kiplinger.com/personal-finance/travel/ski-retirement-travel-trend (accessed April 28, 2026). [7] Id. [8] Id. More SML Planning Minute Podcast Episodes This podcast is brought to you by Security Mutual Life Insurance Company of New York, The Company That Cares®. The content provided is intended for educational and informational purposes only. Information is provided in good faith. However, the Company makes no representation or warranty of any kind regarding the accuracy, reliability, or completeness of the information. The information presented is designed to provide general information regarding the subject matter covered. It is not to serve as legal, tax or other financial advice related to individual situations, because each individual's legal, tax and financial situation is different. Specific advice needs to be tailored to your situation. Therefore, please consult with your own attorney, tax professional and/or other advisors regarding your specific situation. To help reach your goals, you need a skilled professional by your side. Contact your local Security Mutual life insurance advisor today. As part of the planning process, he or she will coordinate with your other advisors as needed to help you achieve your financial goals and objectives. For more information, visit us at SMLNY.com/SMLPodcast. If you've enjoyed this podcast, tell your friends about it. And be sure to give us a five-star review. And check us out on LinkedIn, YouTube and Twitter. Thanks for listening, and we'll talk to you next time. Tax laws are complex and subject to change. The information presented is based on current interpretation of the laws. Neither Security Mutual nor its agents are permitted to provide tax or legal advice. The applicability of any strategy discussed is dependent upon the particular facts and circumstances. Results may vary, and products and services discussed may not be appropriate for all situations. Each person's needs, objectives and financial circumstances are different, and must be reviewed and analyzed independently. We encourage individuals to seek personalized advice from a qualified Security Mutual life insurance advisor regarding their personal needs, objectives, and financial circumstances. Insurance products are issued by Security Mutual Life Insurance Company of New York, Binghamton, New York. Product availability and features may vary by state. SubscribeApple PodcastsSpotifyAndroidPandoraby EmailTuneInDeezerRSSMore Subscribe Options
More than just a game—Knicks overcoming odds in game 4 comeback is a parable of resilience; A one and done lifetime cholesterol fix via gene modification; Will cataract surgery interfere with benefits of light exposure? Do amounts of vitamin A in various supplements taken together court the risk of toxicity? Smartphones and social media create real harm for adolescents; Experts determine the exact right amount of sleep down to the minute—but is it overreach?
Want a suitcase of antibiotics? Online “wellness” companies will oblige, but the disruption to your microbiome may last up to 8 years; What's the best form of curcumin? New push to promote nutrition instruction for doctors—is it enough? “Borderline anemia”—what could be the cause?
Perimenopause, Insulin Resistance, and Persistent Muscle & Joint Pain: A Functional Medicine Framework: Nutritionist Leyla Muedin discusses perimenopausal musculoskeletal symptoms—new or persistent joint pain, muscle aches, and tendon problems—and highlights a Clinician's Journal article by physical therapist Tara Moore proposing insulin resistance screening in perimenopausal musculoskeletal care. She explains that declining estradiol during the menopausal transition can worsen insulin signaling, increase visceral fat, and reduce insulin sensitivity, affecting skeletal muscle recovery and potentially contributing to tendinopathies and poor or short-lived responses to localized treatments like PT. The framework emphasizes assessing systemic metabolic contributors (e.g., sedentary behavior, high-carbohydrate nutrition patterns, PCOS, central weight gain, stress, sleep disruption) and addressing mediators such as inflammation and impaired glucose utilization. She suggests integrating metabolic risk assessment, sleep and stress strategies, resistance training, and interdisciplinary referrals, arguing that nutrition and supplementation—especially a low-carb approach—may improve recovery and pain outcomes.
Deprescribing thyroid and other meds in older adultsCan I safely take serrapeptase for longer than four weeks?I want to take nattokinase but isn't there a 'clot dislodging' risk?Could you discuss C. difficile and how to treat it?
I do stair climbing indoors in bad weather instead of walking outdoors. Is this worthwhile?The FDA no longer recommends use of radiation shields during X-ray procedures. What say you?I have a queasy stomach feeling, and my blood sugar is higher than usual. What are your thoughts?I've been using magnesium taurate to control palpitations and find I need more than usual.A comment about performance-enhancing drugs in professional sports
What if the true bottleneck to living longer isn't your heart—but your brain?In this episode of The Aging Well Podcast, Dr. Jeff Armstrong and co-host Corbin Bruton explore the emerging concept of neuro-longevity—the idea that preserving brain health is central to extending both lifespan and healthspan. Drawing on insights from recent conversations, including themes raised by Nawal Roy in Episode 398, this episode connects the dots between metabolism, mental health, sleep, and cutting-edge interventions.From the role of mitochondrial function and metabolic flexibility to the growing interest in ketogenic diets and psychedelics for neuroplasticity, this episode offers a grounded, science-forward look at what it takes to protect the aging brain in a modern world.Whether you're thinking about dementia prevention, optimizing cognitive performance, or simply staying sharp as you age, this is a conversation you don't want to miss.Please, support The Aging Well Podcast by hitting the ‘like' button, subscribing/following the podcast, sharing with a friend, and….Tip Jar! All donations support this podcast to keep it going. https://paypal.me/theagingwellpodcastBUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) and the new Copper Tripeptide (GHK-Cu) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastNutritional Biochemical Inc. (NBI) | Trusted supplement. NBI stands 100% behind the quality of their formulations and the science on which they're based. | Click the following link and use the discount code AGINGWELL for 10% off: https://shop.nbihealth.com/agingwellJigsaw Health | Trusted supplements. “It's fun to feel good.” | Click the following link and use the discount code AGINGWELL for 10% off: https://bit.ly/4ks3Y0OBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://www.oxfordhealthspan.com/AGINGWELLKneeMo | A smart device programmed to reduce your knee pain and keep you moving. | Click the following link and use the discount code AGINGWELL15 for 15% off: https://thekneemo.com/ref/agingwellProlon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastThrive25 | Your personal longevity advisor | https://www.thrive25.com/early-access?via=william-jeffreyFusionary Formulas | Combining Ayurvedic wisdom with Western science for optimal health support. | 15% off Code: AGINGWELL | https://fusionaryformulas.com?sca_ref=9678325.IHg5xYhdOzzke8ZrDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELL*We receive commission on these purchases. Thank you.
In this Q&A episode, I answer questions about how to train for varied competitive distances without getting pulled in too many directions, explain my compelling stance on avoiding coffee (and NSAIDs), and give a plug for Dr. Doug McGuff’s “Big 5” total-body workout—a simple, highly effective way to stay strong with just one workout per week. I also share thoughts on how corporations like Whole Foods Market and PF Chang’s continue to sell plenty of crap despite their healthy reputations, discuss the magic of Zone 1 walking for building awesome aerobic fitness, and explain one of the best ways to tell if you’re doing too much strength training. Hint: you shouldn’t be getting sore. These are practical, everyday insights you can use right away to simplify your training, improve your health, and avoid some common mistakes. TIMESTAMPS: Jack, age 60, asks about his running goals. He says he is confused about what Brad says the parameters should be. [01:11] Jack has another question about coffee. Is having that stimulant in the morning helpful for your overall well-being as an athlete? [07:38] Another listener asks: Should I take my high intensity interval training, my strength training like Dr. Doug McGruff's Big Five and a basically walking approach to races? [15:45] Some comments from YouTube include this with Brad's comment: How long should you sprint to achieve all the health benefits? Brad's answer: All your entire life. [17:56] Monica initiates a discussion on the industrial seed oils being used rather than butter in restaurants and even Whole Foods and P.F. Changs. [18:50] Anthony asks about building up aerobic fitness by walking. Brad's response is thatthe aerobic base is built at the lower exercise intensities where your body has sufficient oxygen to develop and fine tune your mitochondrial function [27:00] Chad experiences soreness after trying to complete body weight exercises every other day to failure. Brad answers: If you have recurring soreness from your strength training regimen, you are most certainly overdoing it. [30:48] Dr. Doug McGruff's book, Body by Science, has a great regimen of five big workouts to do once a week. [32:22] Chad is also asking about his schedule for training. You want to have ebbs and flows in your schedule such that you have built in downtime and you always respect the importance of intuition and adjusting on the fly. [37:37] LINKS: Brad Kearns.com BradNutrition.com - 20% OFF Your First Order! B.rad Superdrink – Hydrates 28% Faster than Water—Creatine-Charged Hydration for Next-Level Power, Focus, and Recovery NEW: B.rad Real Rad Gummies - Creatine + Nootropics for Focus, Motivation, Performance, and Recovery! B.rad Whey Protein Superfuel - The Best Protein on The Planet! Brad’s Shopping Page BornToWalkBook.com B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes - Save 10% Body by Science We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. Seriously, I won’t promote anything that I don't absolutely love and use in daily life: B.rad Nutrition: Premium quality, all-natural supplements for peak performance, recovery, and longevity; including the world's highest quality whey protein! Get 20% OFF your first order! Peluva: Comfortable, functional, stylish five-toe minimalist shoe to reawaken optimal foot function. Use code BRADPODCAST for 15% off! Jaspr Air Scrubber: Ultra high-performance air purifier - blows other air filters away! Save $200 on your unit with code BRAD. Get Stride: Advanced DNA, methylation profile, microbiome & blood at-home testing. Hit your stride the right way, with cutting-edge technology and customized programming. Save 10% with the code BRAD. Online educational courses: Numerous great offerings for an immersive home-study educational experience Primal Fitness Expert Certification: The most comprehensive online course on all aspects of traditional fitness programming and a total immersion fitness lifestyle. Save 25% on tuition with code BRAD! #bradpodcastSee omnystudio.com/listener for privacy information.
Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics, explains how membrane damage from free radicals and loss of mitochondrial transmembrane potential contribute to declining energy with age, noting studies in older adults showing improved energy output, fatigue, cognition, mood, and activity after NTFactor lipids, a protected phospholipid supplement balanced toward mitochondrial lipid composition. He describes evidence of lipid delivery using fluorescent-tagged lipids in sperm, with improved motility, and discusses applications including wound healing in veterans, removal of hydrophobic toxins via a concentration-driven “conveyor belt” process, and improved transport of nutrients like CoQ10. He details articles on normal aging, menopause-related changes supported by membranes, dementia risk linked to hearing loss, and rat studies showing delayed hearing loss with NTFactor, and mentions research on EMF sensitivity and planned schizophrenia trials.
Dr. Hoffman continues his conversation with Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics.
AI founders call for Congress to set guardrails against AI-accelerated bioweapon development; Deprescribing thyroid medication in seniors; Low-arginine/high lysine diets vs. herpes; Researchers test the “5 second rule” for dropped food; Long-term antidepressant use comes under new scrutiny.
The “Enhanced Games”, with no-holds-barred performance-enhancing drugs, yields scant advantages over “clean” contests; Does saturated fat increase insulin resistance? Can a heart attack victim avoid statin use with CoQ10? Omega-3 fish oil shows promise vs. type 2 diabetes; Motorized e-scooter use needs to be regulated NOW!
The Real Truth About Health Free 17 Day Live Online Conference Podcast
Single nutrients don't tell the full story. Learn how whole foods work synergistically to prevent chronic illness. #WholeFoods #PlantBasedHealing #NutritionScience
Nutritionist Leyla Muedin discusses research showing simple strength tests—grip strength and a five-rep sit-to-stand chair test—predict longevity in older women. In a University at Buffalo study of over 5,000 women ages 63–99 followed for eight years, stronger grip and faster chair-stand times were linked to lower mortality; every additional 7 kg of grip strength corresponded to a 12% reduction in death risk, and faster chair-stands were also associated with improved survival, even after adjusting for activity, cardiovascular fitness, and inflammation. She emphasizes prioritizing muscle-strengthening alongside aerobic exercise and suggests accessible resistance options (weights, bodyweight moves, or household items) with professional guidance as needed. She then cites UK Biobank data linking long-term statin use to declines in grip strength and appendicular lean mass, urging discussion with physicians and added vigilance, especially for those also using GLP-1 drugs that may reduce protein intake and muscle mass.
June 4, 2026 City Club event description: Join us for a conversation on the growing focus on healthspan and why Illinois is well positioned to lead this emerging field. As the conversation around aging shifts from simply living longer to living healthier for longer, this panel will explore the science, innovation and economic opportunity driving […]
Can topical B12 help relieve itching?The types of doctors to avoidGetting back to basicsA case study of lavender oil helping to relieve itchingYou say you're dairy sensitive but you use whey protein. Please explain.What are your thoughts on a lactose relief patch that is on offer?
Is high blood pressure genetic? Are we stuck having to take blood pressure meds?Could you please critique the study asserting fish oil supplements elevate the risk of atrial fibrillation?I've had strep throat three times in two months! What gives?I've had queasy reactions to protein added foods
Dr. Julie Chen, Chief Medical Officer at Radence, outlines the use of genomic precision medicine and advanced biomarkers and imaging technology for early detection and diagnosis of disease, with a focus on extending the health span, not just the lifespan, of their clients. This comprehensive membership-based model aggregates members' health data to create a 360° view of their health risks. AI is a critical tool for identifying trends in longitudinal data, enabling more accurate and personalized health monitoring for both those who are healthy and those recovering from an existing condition. Julie explains, "Our model is a membership-based model primarily because a lot of the leading-edge technology is not insurance-covered. And so we're able to then utilize what is necessary for the diagnosis and the management, and actionable steps for the members, without having to worry about what insurance will or will not cover." "Our members come through, and we actually aggregate all of their outside medical records and data because we want to see what their baseline health has been up to the point that they join us as a member. And then at that point, we actually get from the cellular level all the way up to the organ level and functionality level, we start to aggregate information about their genomics, so the blueprint of who they are health-wise." "The key focus here is really looking at the concept that longevity is a larger picture phrase that has been in this industry, used across the board for a lot of different things. That could encompass biohacking, to true evidence-based genomic precision medicine, to just trends of what people are using. So I think it's really important for your listeners to understand that longevity is theoretically in the category of what we're doing in that space, but the very important point is to really look at the space, as there are a lot of things on the market now." #Radence #GenomicMedicine #PrecisionMedicine #EarlyDetection #HealthSpan #Longevity #AIinHealthcare #PreventiveCare Radence.com Download the transcript here
Dr. Julie Chen, Chief Medical Officer at Radence, outlines the use of genomic precision medicine and advanced biomarkers and imaging technology for early detection and diagnosis of disease, with a focus on extending the health span, not just the lifespan, of their clients. This comprehensive membership-based model aggregates members' health data to create a 360° view of their health risks. AI is a critical tool for identifying trends in longitudinal data, enabling more accurate and personalized health monitoring for both those who are healthy and those recovering from an existing condition. Julie explains, "Our model is a membership-based model primarily because a lot of the leading-edge technology is not insurance-covered. And so we're able to then utilize what is necessary for the diagnosis and the management, and actionable steps for the members, without having to worry about what insurance will or will not cover." "Our members come through, and we actually aggregate all of their outside medical records and data because we want to see what their baseline health has been up to the point that they join us as a member. And then at that point, we actually get from the cellular level all the way up to the organ level and functionality level, we start to aggregate information about their genomics, so the blueprint of who they are health-wise." "The key focus here is really looking at the concept that longevity is a larger picture phrase that has been in this industry, used across the board for a lot of different things. That could encompass biohacking, to true evidence-based genomic precision medicine, to just trends of what people are using. So I think it's really important for your listeners to understand that longevity is theoretically in the category of what we're doing in that space, but the very important point is to really look at the space, as there are a lot of things on the market now." #Radence #GenomicMedicine #PrecisionMedicine #EarlyDetection #HealthSpan #Longevity #AIinHealthcare #PreventiveCare Radence.com Listen to the podcast here
In this episode, Emily Capodilupo sits down with gerontologist, leadership coach, and author of The Middlescence Manifesto Barbara Waxman to explore the powerful idea of “middlescence” — a transformative stage of life between young and late adulthood. Together, they unpack why midlife isn't a crisis, but an opportunity for reinvention, alignment, and growth. Listeners will learn how mindset, purpose, relationships, and joy directly impact an individual's healthspan and longevity. Emily and Barbara share the best strategy to use wearable data as a tool for self-awareness rather than self-judgment. This conversation is full of practical insights on flourishing at every age, redefining success, and building a life that feels both healthy and deeply meaningful.(00:33) Intro to Barbara Waxman(01:00) What is Middlescence? How To Redefine Midlife(03:20) Addressing This New Life Stage & Creating Change(06:22) Coaching People Through Midlife(08:15) Debunking The Concept of the Midlife Crisis(09:57) Key Lifestyle Shifts From a Life Coach(12:23) 7 Lifestyle Levers: Where People Start To Prepare for Middlescence(17:21) Reframing Longevity: Live Better, Not Just Longer(19:37) How Barbara Uses WHOOP Data In Her Practice(25:54) Lifestyle Considerations For A Healthy Life Beyond Longevity & Healthspan(34:51) How People in Their 20s, 30s, 40s,and 50s Can Increase LongevityFollow Barbara Waxman:WebsiteLinkedInSupport the showFollow WHOOP:Sign up for WHOOP Advanced LabsTrial WHOOP for Freewww.whoop.comInstagramTikTokYouTubeXFacebookLinkedInFollow Will Ahmed:InstagramXLinkedInFollow Kristen Holmes:InstagramLinkedInFollow Emily Capodilupo:LinkedIn
Dr. Hoffman continues his conversation with holistic practitioner Jane Jansen.
A Brand New Tool for Gut, Inflammation, and Brain Support: Holistic practitioner Jane Jansen details Essential Formulas' Dr. Ohhira's Postbiotic Fermented Food Concentrate, a non-GMO, gluten-free, dairy-free, capsule-free fermented paste in travel-friendly, non-refrigerated sachets. She explains the difference between probiotics and postbiotics, emphasizing that this concentrate delivers postbiotic metabolites (including short-chain fatty acids like butyrate, plus enzymes, amino acids, vitamins, peptides, and growth/repair factors) created via a five-year fermentation of 14 fruits, vegetables, mushrooms, and seaweeds; the paste contains no live probiotics because they are heat-killed. The discussion highlights use cases for people who don't tolerate fiber or probiotics (IBS, SIBO, Crohn's, ulcerative colitis), potential benefits for leaky gut, systemic inflammation, gut-brain/mitochondrial health, insulin resistance, children, and pets, and suggests it can complement Dr. Ohhira's capsules and may be taken less than daily.
Dr. Hoffman continues his conversation with integrative veterinarian Dr. Judy Morgan, DVM, CVA, CVCP, CVFT.
Naturally Healthy Pets: Whole-Food Diets, Microbiome Repair, and Integrative Therapies with integrative veterinarian Dr. Judy Morgan, DVM, CVA, CVCP, CVFT. She argues that pet ownership benefits human wellbeing and that pets concentrate household toxins, warning against routine pesticide-based flea/tick and other veterinary drugs due to environmental contamination and adverse events. She recommends species-appropriate whole-food diets (cats as obligate carnivores; dogs mostly meat) and criticizes ultra-processed pet foods, synthetic nutrient premixes, grains/legumes in kibble, and high-carb diets that fuel yeast and inflammation; she discusses safe calcium, zinc, and vitamin D sources. In part two, she describes veterinary acupuncture, chiropractic, and laser/red-light therapies with case examples, links skin/ear “allergies” to gut dysbiosis, uses microbiome testing, FMT capsules, and detox support, highlights omega-3s, PEA for pain, and CBD for seizures/anxiety, and outlines multi-layered natural flea/tick prevention. Intelligent Medicine listeners can get 50% off Dr. Judy authored books found on NaturallyHealthyPets.com. Just use the coupon code INTELLIGENT50.
Soon-to-arrive drugs promise to address elevated Lp(a); Best natural alternatives to repel mosquitoes and ticks; When cancer treatments cause osteoporosis; Organoids and computer simulations promise to reduce the toll of live animal experimentation; Land snails and pythons yield clues for new drug development; Shortfall in doctors accelerated by early retirement as physicians cite “hassle factor.”
A tale of 2 pneumonias—NASCAR racer Kyle Busch dead at 41 while Rudy Giuliani, age 81, survives critical care; Newly discovered evidence that Neanderthals were practicing dentistry—59,000 years ago! “Fatty 15”—does it measure up to the hype? Stem Wave—A shocking way to obtain pain relief; When to give antibiotics for a tick bite; Proposed ban on tobacco products for future generations of Brits aims to eradicate smoking.
What does it mean to age well? In 2026, the conversation has officially shifted from lifespan—how many years we live—to healthspan—how well we live those years. In this episode, host Michele Lawrence sits down with pioneering medical doctor and certified yoga therapist Dr. Baxter Bell to discuss the intersection of Western medicine and yoga.Baxter shares his personal evolution from working as a busy family physician in the 1990s to stepping onto the mat full-time as a global leader in the yoga therapy community. Together, they dive into the medical science behind why strength, flexibility, and balance are non-negotiable for longevity, how the practice of equanimity translates into a physical felt-sense during times of uncertainty, and the cutting-edge neuro-protective elements of yoga that help prevent Alzheimer's disease. Whether you are navigating your own mid-life transition or supporting clients through the second half of life, this episode offers a masterful blueprint for building a resilient mind and body.Key Takeaways & HighlightsThe Doctor's Pivot: Baxter discusses the professional and personal drivers that led him to transition away from full-time family medicine to pursue yoga as a primary path.Healthspan vs. Lifespan: Why modern longevity is about optimizing physical and mental vitality, and how yoga therapy targets the physical "Big 3" (Strength, Flexibility, and Balance) fundamentally differently than a standard gym workout.The Anatomy of Longevity: The direct medical connection between maintaining supple, mobile tissues and long-term biological longevity markers.Equanimity as Medicine: Moving equanimity out of the realm of philosophy and into a practice for individuals facing difficult medical diagnoses or age-related transitions.Neuro-Protection on the Mat: Clinical insights into how a dedicated yoga therapy practice acts as an effective, preventative intervention against cognitive decline and Alzheimer's disease.Connect with Dr. Baxter BellWebsite: BaxterBell.comDiscover: Explore Baxter's Winter 2026 workshop series, latest courses, and upcoming global retreats.Read: Yoga for Healthy Aging: A Guide to Lifelong Well-Being (Co-authored by Dr. Baxter Bell)Support the showConnect with Inner Peace Yoga TherapyEmail us: info@innerpeaceyogatherapy.comWebsiteInstagramFacebook
Registered dietitian nutritionist Leyla Muedin discusses the growing interest in biological age versus chronological age and explains that biological aging is modifiable through consistent lifestyle choices. She outlines common measurement tools and biomarkers, including epigenetic clocks (DNA methylation), telomere length, VO2 max, inflammatory markers, grip strength, and muscle mass, noting that genetics account for only about 25–40% of biological aging variation. Key interventions include regular aerobic and resistance exercise, protein-adequate nutrition to preserve muscle and prevent sarcopenia (with whey protein and leucine-rich foods noted), improved sleep, stress management, reducing processed foods and visceral fat, and lowering chronic inflammation (CRP, IL-6). She also reviews hormetic stressors such as sauna use and mentions red/near-infrared light and sun exposure without sunglasses. Leyla shares client examples showing biological age can worsen or improve, and encourages repeat testing after lifestyle changes.