measure of average lifespan in a given population
POPULARITY
The benefits of kimchi for detoxing microplasticsWhat do you recommend my husband take to recover from Bell's Palsy? Follow-up on coronary artery inflammation question
The benefits of PilatesWhat does it mean that certain brands of nattokinase are "free of K2"?Should I avoid soy products due to my history of breast cancer?How can I choose the best fish oil? Is there a certain dose you recommend?Is there any other supplement I can take besides 5-HTP for mood? What about SAMe?Is there any relief for my friend with ulcerative colitis?
What happens when gut health, menopause, peptides, nutrition, and food policy all start converging? After seven years of conversations about the future of wellness, the trends are pointing toward a bigger shift: new tools may change how we approach healthspan, and yet the fundamentals still matter.Host Jenn Trepeck closes out The Next Frontier Files, the seven-episode miniseries retrospective from Salad With a Side of Fries as she reflects on year seven. She shares her own take on the next frontier in wellness, and explains how peptides and food policy fit into the future of healthspan. It is a big-picture reminder that the basics still matter most, no matter which new trend arrives next.What You Will Learn in This Episode:✅ Why convergence is the defining theme of year seven, with gut health, menopause, and peptides appearing together like never before.✅ How the GLP-1 boom is pushing fiber and micronutrients into the spotlight, and why muscle wasting is a risk of eating too little.✅ Which foundations, from nutrition and sleep to community, protect your healthspan when new biohacking tools arrive.✅ How a proposed reckoning with the food supply and processed foods could make quality nutrition more affordable.The Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into real-life wellness and weight loss, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Welcome to the year seven finale and a look at how wellness trends all converge at once04:15 Philip Pape begins year seven recap with precision medicine, genetics, and artificial intelligence joining forces07:19 Abby Sharp warns against the pathologizing of hunger and our bond with food11:51 Jared St. Clair discusses why gut health and microbiota transplant may explain more than digestion, including mental health13:06 Dr. Stan Pierce shares his perspective on Neuralink, brain-computer interfaces, and new funding for brain research that could change healthcare16:06 Hormones, menopause, thyroid, and peptides as five voices reach beyond their own topics19:14 Sarah Wragge predicts Fiber and micronutrients will take center stage as GLP-1 users risk bone density and muscle loss20:14 Dr. Diane Mueller discusses why aging gets blamed too often, and how community, connection, and cortisol shape healthspan24:38 Dr. Eric Osansky discusses the relationship between cortisol and stress management26:01 Molly McNamee says let's get back to basics: why foundations of health never go out of style as new trends keep cycling26:38 Jenn pulls together all the predictions as well as her own thoughts for the next frontier in wellnessKEY TAKEAWAYS:
Dr. Hoffman continues his conversation with Dr. Jeffrey Bland, founder of the Personalized Lifestyle Medicine Institute and Big Bold Health, about fish oil and omega-3 science.
Fish Oil, Full-Spectrum Omega-3s, and Immunometabolism with Dr. Jeffrey Bland: Dr. Ronald Hoffman interviews Dr. Jeffrey Bland, founder of the Personalized Lifestyle Medicine Institute and Big Bold Health, about fish oil and omega-3 science. Bland recounts becoming involved with commercial fish oil in 1980 while promoting MaxEPA amid the “fat is bad” era and discusses Greenland Inuit research showing high omega-3 blood levels and low heart disease. They contrast whole-food omega-3 intake with highly refined EPA/DHA products, highlighting additional constituents in minimally processed oils (vitamins A and D, astaxanthin) and precursor compounds related to specialized pro-resolving mediators. Bland describes Omega-3 Rejuvenate's Alaska line-caught sourcing and low-heat, chemical-free processing, and addresses concerns about mercury, microplastics, and vitamin A dosing. The conversation also covers PLMI's focus on immunometabolism, a CBC-derived SIRI marker, omega-3 insufficiency data from Fullscript, mitochondrial membrane support by DHA, and Bland's upcoming book, “The Nourished Gene.”
Dr. Hoffman continues his conversation with clinical pharmacist and nutritionist Jim LaValle about cardiovascular risk factors beyond total cholesterol.
Cholesterol Beyond the Basics: ApoB, Lp(a), Stress, and Aged Garlic Extract for Cardiovascular Risk: Dr. Ronald Hoffman interviews clinical pharmacist and nutritionist Jim LaValle about cardiovascular risk factors beyond total cholesterol, emphasizing that blood tests measure lipoprotein particles and subfractions rather than cholesterol itself. They discuss limitations of relying on surrogate markers, the role of lifestyle (diet, exercise, sleep, stress, glucose control), and advanced markers such as ApoB, Lp(a), oxidized LDL, and Lp-PLA2, noting that lowering Lp(a) or improving markers doesn't always improve outcomes. LaValle highlights ApoB as a key risk barometer, reviews evidence for aged garlic extract lowering ApoB, slowing coronary artery calcification, regressing vulnerable plaque, and improving vascular function, and supports combining supplements with appropriate medications. They address lean-mass hyper-responders on ketogenic diets, debate broad statin use in seniors, and cover stress/cortisol dysregulation, hormone effects, and appropriate use of GLP-1 drugs for weight and metabolic risk.
What if living longer and better has less to do with extreme diets and biohacks, and more to do with a few simple habits you already know you should be doing?In this episode of Owning Your Legacy, host Laurette Rondenet sits down with Dr. Avanti Kumar-Singh, MD, a physician, Ayurvedic expert, and author of The Longevity Formula and The Health Catalyst. During her emergency medicine training, Dr. Avanti was 20 pounds overweight, battling headaches and stomach problems, and every lab came back "normal." She went back to the Ayurvedic lifestyle she grew up with, one small change at a time, and has spent the past 20 years bringing 5,000 years of Ayurvedic wisdom together with Western medicine.Dr. Avanti makes the case that longevity is really about healthspan: reaching 95 or 100 while you are still active, sharp, independent, and connected to the people and work that matter to you. And she shows how to get there without overhauling your life.Inside the conversation:• Healthspan vs. lifespan: why the anti-aging conversation misses the point• The 12-12-12 framework: 12 minutes of morning sunlight, a 12-hour overnight fast, and 12 minutes of daily stress reduction• Why women's sweet spot for fasting is 12 to 14 hours, and how longer fasts can stress hormones• Rest is not sleep: micro-breaks, breathwork, and why stress management is inflammation management• Doshas at work and at home: using Vata, Pitta, and Kapha to understand your team, your partner, and yourself• Grounding, prana, and why a walk among trees feels so restorative• Her breast cancer journey, why she calls Ayurveda "protective, not just preventative," and learning to receive loveBooks & resources mentioned:• The Longevity Formula by Dr. Avanti Kumar-Singh• The Health Catalyst by Dr. Avanti Kumar-Singh• Dosha assessment and weekly articles: The Weekly Health Rx on Substack (avantikumarsingh.substack.com)• The Healing Catalyst PodcastConnect with Dr. Avanti at avantikumarsingh.com, on Instagram (@avantikumarsingh), and on LinkedIn. Follow Laurette Rondenet and subscribe to Owning Your Legacy for more candid conversations on purpose, leadership, and building what lasts.This episode is for educational purposes and is not medical advice. Talk with your physician before changing your fasting, diet, or health routine.If you enjoyed the episode please share it with others, and rate, review, and subscribe wherever you get your podcasts. To learn more about me and how I am Owning My Legacy, you can find me on Instagram @LauretteRondenet and online at lauretterondenet.com.
Welcome to "Thriving in Midlife" The Women's Guide to Wellness, Longevity & Hormones After 40. This is your trusted space to cut through the noise, ditch the overwhelm, and finally feel extraordinary in your body, mind, and life. Are you ready to stop pushing through life and start living it with intention, energy, and ease? Then let's get started. I'm your host, Kellie Lupsha, a high-performance health coach, who is delighted to be your guide to vitality.Testosterone is often discussed as a hormone connected primarily to men, libido, or sexual function. But what if there is a much bigger conversation we need to have about testosterone and women's health?In this conversation, we explore why testosterone may play an important role in the body, how it connects with other hormones, and why muscle and strength training deserve more attention during midlife.We also talk about testosterone testing, the difference between total and free testosterone, different delivery methods, and why individualized monitoring matters.Then we take the conversation a step further and explore peptides and growth hormone signaling as another pathway being discussed by some practitioners.What You'll Learn* Why Testosterone Matters for Women. We explore why testosterone deserves to be part of the broader conversation around women's health, including its relationship with the brain, muscles, bones, heart, energy, and overall well-being.*The Connection Between Muscle and Testosterone. Strength training is a major part of this conversation. We discuss how working larger muscle groups can create signals that support the body's natural hormone pathways and why every woman can find some form of resistance training that fits her abilities.* Why More Testosterone Is Not Always Better. More is not automatically better when it comes to hormones. We discuss the importance of individualized dosing, monitoring, and working with an appropriate healthcare professional when considering hormone therapy.* Total Testosterone vs. Free Testosterone. We break down the difference between total and free testosterone and why looking beyond one number may provide more context when evaluating how testosterone is being produced and utilized in the body.*Testosterone, Health Span, and Longevity. We connect the testosterone conversation to the bigger picture of health span versus lifespan and explore why maintaining strength, mobility, hormone balance, and overall health may matter as we move through midlife and beyond.Key Takeaways“The body is built by design, and it's beautiful by design.”“Muscle is the best bang for your buck when it comes to overall health and longevity.” -Kellie LupshaThe more testosterone we use, the stronger everything gets.”“Instead of looking for an outside source, get the muscle going and see what your body can make.” HeidiMy product recommendations My “Shop My” link: https://shopmy.us/shop/kellielupsha?tab=latest1️⃣ Take The Activated Woman Quiz: Why Do I Still Feel Off No Matter What I Try?Finally discover what's really going on. Take this personalized quiz to uncover the system driving your symptoms and the strategic shift your body needs to respond again.2️⃣ JOIN US IN THE ACTIVATED WOMEN'S CIRLE Offering a 14-day trial for only $11A Functional Wellness and Coaching Membership designed just for women over 40. The Activated Women's Circle is a monthly membership and supportive community where we combine science-backed protocols, natural healing tools, and expert coaching to help you finally get real answers and real results.
For most of us, the doctor only sees our blood pressure, weight and oxygen levels a few times a year, usually when something is already wrong. Is that really health care, or just sick care?In this episode of Experiencing Healthcare, Jamie Preston sits down with Your Health CEO Matt Staub to talk about remote patient monitoring (RPM). RPM is the subject of Matt's master's thesis and a program he championed from day one. He explains why Your Health invests in daily data when many fee-for-service systems hand out devices only after a crisis and take them back once things settle down. He also explains why he's proud to call himself "the most compliant patient in the practice."In this episode:How daily weigh-ins can catch fluid retention in heart failure patients before it turns into a hospital stayWhy the data matters as much to the patient as it does to the provider, and how it helps people build habits that stack on each otherWhy RPM should be tailored rather than one-size-fits-all, including when daily tracking can backfireWhat happens when a healthcare company holds its own workforce to the standard it asks of patients, with "grace with accountability"How healthier employees can mean lower insurance costs, stronger recruiting and happier teamsIf you lead a practice, run a business or care for an aging parent, this conversation will change what you think it means to stay healthy between appointments.
Deadline looms for ban on hemp-derived CBD/THC products—while legal pot proliferates; Scientists disclose IBD benefits of urolithin A; “Dry-fasting” is a new fad—is it healthy? Short “exercise snacks” to break up prolonged inactivity benefit attention and cognition; Kimchi and designer probiotics show promise for flushing out microplastics; LSD soon to be approved as a prescription for anxiety.
We take the keys away from older drivers—why not older doctors? Nearly 3 in 4 Americans battling this health problem—fatigue! What super-agers over 100 have in common—a hyper-vigilant immune system guarding against cancers and infections. How does “anabolic resistance” contribute to frailty—and what to do about it? Recurrent bouts of “burning sensations” on the face—diagnosis please?
This timely conversation explores the growing interest in peptides—short chains of amino acids that act as natural messengers, helping cells communicate and supporting important functions such as muscle health, metabolism, sleep, recovery, and healthy aging. The discussion examines how peptides occur naturally in the body and certain foods, how oral peptides move through digestion, how they differ from synthetic or injectable forms, and why peptide science is attracting so much attention. It also highlights the future of peptide research and the passion that ultimately led to the development of MAKE Wellness. Mimi Allen Biography Mimi is a San Diego native with a background in pharmaceutical sales, plant-based wellness, and longevity science. She started her career in dermatological pharmaceutical sales, where she developed a strong foundation in skincare, health, and aging, which ultimately sparked her passion for optimizing wellness from the inside out. She went on to gain hands on experience in the emerging CBD industry, further strengthening her dedication to natural, plant-derived wellness solutions. Today, Mimi is focused on MAKE Wellness, a company transforming the way we think about healthy aging, performance, and vitality through bioactive precision peptides derived from plants and food, designed to work in harmony with the body’s natural systems. Attracted to MAKE’s science backed innovation and leadership in a fast-growing category, Mimi joined the company after recognizing both the strength of the research and the potential of this new frontier in wellness. MAKE Wellness achieved $117 million in revenue in its first year, highlighting the strong demand for its groundbreaking approach. As a single mother of two sons, Mimi is deeply committed to supporting health-conscious adults, especially those 40 and older, who want to age well while preserving their energy, strength, mental clarity, appearance, and overall quality of life. She is passionate about sharing natural, science driven solutions that nourish the body from within and help people stay active and thriving for years to come. It’s all about HEALTHSPAN and not lifespan. Website: https://makewellness.com/mimi/Shopping/Share?promo=give10Support the show: http://www.cooleyfoundation.org/See omnystudio.com/listener for privacy information.
Jerry Hickey discusses Multivitamins, and Dr. Amanda zeroes in on Supplements for the Heart and Circulation .See omnystudio.com/listener for privacy information.
Sleep, Growth Hormone, and Autophagy: How Rest, Diet, and Fasting Support Metabolic Health and Longevity: Nutritionist Leyla Muedin discusses how deep, early non-REM sleep boosts growth hormone for muscle, bone, fat burning, and metabolic health, and reviews a Cell study in which UC Berkeley researchers mapped hypothalamic circuits and feedback through the locus coeruleus showing a tight balance between sleep, growth hormone release, and wakefulness, with implications for metabolic disease and neurodegeneration. She connects poor sleep to higher blood sugar, insulin, and cortisol, which can suppress growth hormone, and advises avoiding sweet post-workout foods (e.g., smoothies, bananas, fruit yogurt) that stimulate insulin and blunt growth hormone, recommending protein and fat instead. She then explains autophagy and mitophagy as cellular cleanup processes linked to longevity, noting autophagy peaks after 12 hours of fasting, highlighting roles in mitochondrial quality control, immunity, and neurodegenerative disease, and mentions interventions such as fasting, exercise, ketogenic diets, and investigational inducers like rapamycin and urolithin A.
Six years of experts. One question asked every single time, and a pile of predictions that either aged beautifully or fell apart on contact with reality. Some of the boldest claims came wrapped in credentials, while some of the quietest answers turned out to be the ones worth keeping. Year six was when the wellness conversation got loud enough that discernment became the real skill.On this episode of The Next Frontier Files, Jenn Trepeck plays back year six of the next frontier in wellness answers and hands-down verdicts. Fat cells that remember your old weight. Menopause research that still has not arrived. Peptide therapy sitting next to skin tanning in the same sentence. Artificial intelligence in medicine, and the guest who predicted the backlash a year before it happened. Plus a hydrogen claim about living into the thousands that deserves the raised eyebrow it gets.What You Will Learn in This Episode:✅ Why fat cell memory rewrites the RNA of your cells and makes weight maintenance harder after rapid loss, especially after GLP-1 drugs✅ How genetics and the microbiome shift with your environment, which is why one-size-fits-all advice keeps failing✅ What methylation risk scores and biological age testing could unlock as they move toward FDA approval✅ The difference between a wearable data point and the time, care, and listening that actually changes outcomesThe Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into real-life wellness and weight loss, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Jenn shares why seven years of wellness trends became a seven-part miniseries built from one rapid-fire question04:45 The year six theme arrives, exploring fat cell memory and being on the same team as your own body05:19 Professor Ferdinand von Meyenn on prevention, health span, and incentivizing care before disease07:38 Dr. Kathy Campbell on genetics and the microbiome as two universes of variables and complexity08:57 Hannah Went discusses the methylation risk scores and FDA approval09:33 Vince Sant on peptide therapy for joint health, muscle recovery, and where the claim drifts10:41 Zora Benhamou and Monica Packer discuss menopause research gap and gender neutral studies11:56 Ashley Fillmore feels like the future is bright, but hopes it will be more affordable for the average consumer13:01 Jenn Malecha shares a new frontier of functional medicine for pets16:23 Dr. Dana Stern on artificial intelligence and predictive health18:25 Dr. Andrea Nakayama feels the frontier is going to be wearables, but has thoughts about where she wishes it was going19:39 Greg the Hydrogen Man claims reversed aging and a device that does not exist yet21:58 Martin Pytela hopes that the HHS will find that drugs should be regulated separately from food23:44 Getting back to basics with real food, daily movement, consistency, and self-kindnessKEY TAKEAWAYS:
To start our new series about what it means to live in a world of ageing populations, David talks to geneticist Adam Rutherford about the benefits and pitfalls of increasing longevity. Are GLP-1s – drugs like Ozempic, Wegovy and Mounjaro – miracle cures that will extend human lifespans? What happens if longer lives do not coincide with better health? How far can life extension be pushed? And who wants to live forever anyway? Available now: a pair of new educational courses to accompany two of our series – The Great Essays and The Lives of the Philosophers. These courses are free for anyone who wants to use them and offer recall tests, extensive reading guides, discussion topics and essay questions for further reading, writing and exploration around the subjects of our podcasts. For use in schools, colleges or just in your spare time. To explore these courses simply go to https://ppfideas.com/courses Out now on PPF+: ‘Podcast University', a bonus episode to accompany the launch of our new educational courses in which David lays out the thinking behind them and his own ideas about the relationship between what he used to do as a university teacher and what we do now on PPF. To get this and all our bonus episodes plus ad-free listening – and to help support and keep freely available our educational work – subscribe to PPF+ now https://www.ppfideas.com/join-ppf-plus You can find out everything else you need to know about this podcast – who we are, what we do, plus upcoming events and full lists of all episodes including PPF+ bonus episodes on our website https://www.ppfideas.com Next time in An Ageing World: The Meaning of Death They can't harm you, if they can't find you! Use code ppf at the link below and get 60% off annual plans: https://incogni.com/ppf Learn more about your ad choices. Visit podcastchoices.com/adchoices
We may be living longer, but are we actually living healthier?In this episode of the NHA Today Podcast, Dr. Stephan Esser sits down with Charlyn Black, MD, ScD, physician, public health researcher, educator and co-author of Plant Powered Seniors, to explore the growing gap between lifespan and healthspan.Healthspan refers to the years of life spent in good health, rather than years marked by chronic disease, frequent medical care and declining function. Dr. Black explains that while lifespan has increased, the amount of time many people spend in poor health has also increased. In the United States, she points to recent data suggesting that this gap now exceeds 14 years.But aging does not have to mean simply accepting a steady decline in health.Dr. Black explains how our bodies and nutritional needs change as we get older, from changes in nutrient absorption and muscle response to hydration, appetite and caloric needs. She also shares how her own approach to nutrition and movement has evolved as she has aged and why even people who have followed a healthy lifestyle for years may benefit from making adjustments.The conversation also goes beyond individual choices. Drawing on her career in public health, Dr. Black discusses how our food environments, institutions and public policies can either support healthier choices or make them much harder. She argues that improving population health requires both personal action and environments that make healthy living easier.Above all, her message is an encouraging one: it is never too late to make a difference in your health. Whether you are already thriving or managing chronic conditions, changes in nutrition, movement and other lifestyle habits can still matter.In This EpisodeThe important difference between lifespan and healthspanWhy living longer does not necessarily mean living healthierHow nutrition needs and physical function change as we ageWhy a whole food, plant-powered diet may be especially valuable later in lifeThe role of movement in maintaining strength, mobility and independenceWhy sleep, social connection, stress management and avoiding risky substances matter for healthy agingWhy willpower alone is not enough to create healthier populationsHow our food environment influences the choices we makeSimple ways to begin improving your health at any agePlant Powered SeniorsDr. Black is a co-author of Plant Powered Seniors with registered dietitians Brenda Davis and Vesanto Melina. Written specifically for adults 50 and older, the book explores how nutritional needs change with age and how plant-powered nutrition and other healthy lifestyle habits can support better health throughout the later decades of life.Learn more and purchase Plant Powered Seniors:https://plant-poweredseniors.com/Connect with the National Health AssociationJoin the National Health Association:https://membership.healthscience.org/join-membership?Learn more about the NHA:https://healthscience.orgExplore upcoming NHA events:https://healthscience.org/events/If you enjoyed this episode, follow the NHA Today Podcast, leave a review and share it with someone who wants to spend more of their years living with health, strength and independence.
Ron Russell shares his 50-year journey with plant-based eating, starting when there were very few plant-based restaurant options in LA County. He describes the challenges of opening a small cafe that grew into a successful170-seat restaurant focused on healthy vegan options. Running the restaurant provided firsthand experience of how plant-based eating helped his customers overcome health issues, which deepened his understanding of the health benefits. Ron also stresses the significance of gratitude and happiness in longevity, sharing personal experiences with gratitude journaling and community connections. He also notes that happiness and joy appear to be common themes among centenarians in Blue Zones. Ron shares insights from his travels, the difference in lifestyle and stress between the US and other countries, and ways to stay socially connected as one ages.Key takeaways:cooking techniques and tips, focusing on ingredient quality and flavor balance - using good ingredients leads to good resultsimportance of properly cooking greens to preserve nutrients and flavorfocus on nutrient-dense foods like lentils, beans, and greens while limiting grain consumptionfour key areas for longevity: nutrition, fasting, movement and strength, and mind-body wellnesscreate balance when pursuing longevity goals: nutrition, fasting, movement, and mental health must work togetherRon's book Longevity Visa: Steps To Live 20+ Years Longer, Feel Younger, Live Healthier, and Reverse Aging, which contains resources and recipes focused on improving health habits, is available on Amazon and through his website longevityvisa.com. Follow Ron on Instagram @longevityvisa for more recipes and helpful tips. Visit ConfidenceThroughHealth.com to find discounts to some of our favorite products.Follow me via All In Health and Wellness on Facebook or Instagram.Find my books on Amazon: No More Sugar Coating: Finding Your Happiness in a Crowded World and Confidence Through Health: Live the Healthy Lifestyle God DesignedProduction credit: Social Media Cowboys
Dr. Hoffman continues his conversation with Dr. Nate Wood, MD, inaugural director of Culinary Medicine at Yale School of Medicine.
Teaching Nutrition to Doctors: Dr. Nate Wood, MD, inaugural director of Culinary Medicine at Yale School of Medicine, discusses the persistent lack of nutrition education in medical training. Wood defines culinary medicine as combining nutrition science, medicine, education, and culinary skills to help patients and trainees cook health-promoting food. He reviews diet's broad impact on chronic disease (cardiometabolic disease, dementia, cancer, mental health, MS), challenges in nutrition research, and Yale's approach emphasizing plant-forward, minimally processed foods while addressing controversies. Barriers to adoption include crowded curricula, lack of trained faculty, unclear competencies, and limited exam coverage, though nutrition is being added to Step exams. Wood describes free patient classes, community outreach, research showing culinary training boosts counseling confidence, GLP-1s as complementary to lifestyle change, and his upcoming book, “Food Figured Out,” due in 2027.
In this episode of the Science of Skin Podcast, Dr. Ted Lain talks with Dr. Rich Miller, professor of pathology at the University of Michigan and director of the Paul F. Glenn Center for Aging Research, about the science of slowing biological aging.Dr. Miller explains why lifespan and health span move together, not in opposition, and walks through decades of research using genetic mutants, calorie-restricted diets, and drugs like rapamycin, acarbose, canagliflozin, and 17 alpha-estradiol to extend lifespan in mice. The conversation covers how these interventions work through pathways like mTOR and glucose regulation, why some drugs affect males and females differently, and the surprising finding that many of these anti-aging effects hold up even when treatment starts in middle age rather than early in life.The two also discuss the challenge of translating mouse research to humans, Dr. Miller's work developing "aging rate indicators" that could make human drug trials for aging far more practical, and his call for more dermatology involvement in aging research — including his hope to see skin aging studied alongside the organs his lab has already examined. The episode closes with a candid take on supplement industry claims and what the current evidence actually supports for slowing aging today.⚠️ This content is for educational and informational purposes only and reflects the personal research findings and opinions of the speakers. It is not medical advice. The discussion involves animal studies and experimental research; consult a licensed healthcare provider for questions about your own health.If you enjoyed this episode, please leave a 5-star rating and share with a colleague — word of mouth helps our podcast grow!
MDs react to JAMA op-ed claiming autonomous AI will outperform doctors on routine medical tasks by 2030, spurring widespread layoffs: When even intravenous iron isn't enough to stave off anemia; “Emergency “ home medical kits draw ire of medical experts: Meta dinged $567 for teen addiction—why spending it for therapy of adolescents who are hooked on social media may be a waste of money; Adequate vitamin D minimizes post-op pain; When is a second prostate biopsy called for?
Cancer rise in younger adults may be explained by accelerated cellular aging; “Quadriceps activation failure” may explain common waking difficulty following successful knee replacement; Is “Calocurb” a good natural alternative to GLP-1 drugs? New study claims 4 to 6 servings of whole grains may be the key to heart health—but doubts arise due to its authorship in Iran, a hotbed of scientific research fraud; Splenda back in the crosshairs as new evidence points to genetic damage; Bright lights at night emerge as new heart disease risk factor.
What does it mean to be physically capable as we grow older?For Pilates coach and educator Peter Clerkin, it means developing the strength, cardiovascular fitness, balance, mobility and confidence to participate fully in life.A serious football injury at 15, followed by a long recovery and learning to walk again, changed Peter's relationship with movement. He later completed marathons and triathlons and built a career helping other people improve their physical capabilities.In this conversation, Peter explains why Pilates is only one part of a well-rounded physical life. He also discusses exercise after 40, the value of enjoyment and social connection, his decision to stop drinking alcohol and why our ambitions should not diminish as we grow older.--Bio: Peter Clerkin is an Irish Pilates teacher, coach and educator based in London. After graduating in Sport and Exercise Science, he coached soccer in Seattle before moving to London in 2013. Since then, he has completed more than 20,000 hours of teaching and coaching. Peter sees Pilates not as the complete answer, but as one part of a varied and active life. His approach to healthspan begins with what people want to keep doing, from travelling and playing sport to feeling confident trying something new. He is now developing Future Pilates.DISCLOSURE: This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our LIVE LONG SHOP for more details: Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifyEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
Over the past century, average lifespan in Western countries has grown by about 30 years. The years we spend in good health have not kept pace.In this episode of The Mind–Gut Conversation, Dr. Mayer is joined by Dr. Jamie Justice, Executive Vice President of the Health Domain at the XPRIZE Foundation and Executive Director of XPRIZE Healthspan, a $101 million, seven-year global competition to find therapies that restore muscle, cognitive, and immune function in older adults.They discuss the roughly 12-year gap between lifespan and healthspan, why research in worms, flies, mice, and non-human primates suggests aging may be modifiable, and how the XPRIZE competition model rewards teams for demonstrated results rather than proposals. Dr. Justice explains why she does not consider aging a disease, why lifestyle interventions and new therapies should be tested side by side, and what it would take to separate evidence from hype in the consumer longevity market.The conversation closes with the bigger questions: how long humans could realistically live, and how society needs to rethink purpose, work, and technology as more people live into their 80s, 90s, and beyond.Topics discussed include:• Why healthspan has not kept up with lifespan• How the XPRIZE Healthspan competition works• Why aging is a risk factor, not a disease• Lifestyle interventions vs. new longevity therapies• Evidence standards in the consumer longevity market• The limits of lifespan extension and what it means for societyThis is a practical, science-driven discussion for anyone interested in longevity, healthy aging, and the future of aging research.------------------------------This episode is sponsored by Mayer Nutrition, co-founded by Dr. Emeran Mayer. Polyphenols are the plant compounds found in berries, cocoa, green tea and olive oil, and most of their value comes from what happens in your gut: your microbes convert them into compounds your body can absorb and use. Mayer Nutrition makes food and nutrition products built on Dr. Mayer's research into the brain-gut-microbiome system.Save 10% with code MINDGUT. Learn more at mayernutrition.com.------------------------------Chapters:0:00 - Introduction3:37 - Why Has Interest in Longevity Surged?7:02 - Healthspan vs. Lifespan14:35 - Inside the XPRIZE Healthspan Competition24:26 - Lifestyle Interventions vs. New Therapies37:49 - Is Aging a Disease?48:30 - How Long Could Humans Live?56:01 - Closing Remarks
Over the past century, average lifespan in Western countries has grown by about 30 years. The years we spend in good health have not kept pace.In this episode of The Mind–Gut Conversation, Dr. Mayer is joined by Dr. Jamie Justice, Executive Vice President of the Health Domain at the XPRIZE Foundation and Executive Director of XPRIZE Healthspan, a $101 million, seven-year global competition to find therapies that restore muscle, cognitive, and immune function in older adults.They discuss the roughly 12-year gap between lifespan and healthspan, why research in worms, flies, mice, and non-human primates suggests aging may be modifiable, and how the XPRIZE competition model rewards teams for demonstrated results rather than proposals. Dr. Justice explains why she does not consider aging a disease, why lifestyle interventions and new therapies should be tested side by side, and what it would take to separate evidence from hype in the consumer longevity market.The conversation closes with the bigger questions: how long humans could realistically live, and how society needs to rethink purpose, work, and technology as more people live into their 80s, 90s, and beyond.Topics discussed include:• Why healthspan has not kept up with lifespan• How the XPRIZE Healthspan competition works• Why aging is a risk factor, not a disease• Lifestyle interventions vs. new longevity therapies• Evidence standards in the consumer longevity market• The limits of lifespan extension and what it means for societyThis is a practical, science-driven discussion for anyone interested in longevity, healthy aging, and the future of aging research.------------------------------This episode is sponsored by Mayer Nutrition, co-founded by Dr. Emeran Mayer. Polyphenols are the plant compounds found in berries, cocoa, green tea and olive oil, and most of their value comes from what happens in your gut: your microbes convert them into compounds your body can absorb and use. Mayer Nutrition makes food and nutrition products built on Dr. Mayer's research into the brain-gut-microbiome system.Save 10% with code MINDGUT. Learn more at mayernutrition.com.------------------------------Chapters:0:00 - Introduction3:37 - Why Has Interest in Longevity Surged?7:02 - Healthspan vs. Lifespan14:35 - Inside the XPRIZE Healthspan Competition24:26 - Lifestyle Interventions vs. New Therapies37:49 - Is Aging a Disease?48:30 - How Long Could Humans Live?56:01 - Closing Remarks
Concurrent Training for Healthy Aging and the Overlooked B12 Risk of Metformin: Nutritionist Leyla Muedin discusses how concurrent training—combining cardio and strength work—supports healthy aging by building endurance, preserving muscle, and maintaining independence and “healthspan.” She explains that aerobic exercise improves cardiorespiratory efficiency while resistance training preserves lean tissue and functional strength, and offers practical scheduling tips: place strength sessions on two non-consecutive days, add moderate cardio around them, separate hard sessions, prioritize recovery with rest days, sleep, and adequate protein, and avoid pairing heavy lifting with hard endurance work if explosive power is important. She then summarizes evidence that clinicians often fail to check vitamin B12 levels in diabetic patients on long-term metformin, despite guidelines; metformin can impair B12 absorption, leading to deficiency, anemia, and potentially reversible neuropathy, with higher risk in the elderly, high-dose users, vegans, and PPI users. She urges proactive B12 monitoring and supplementation, such as a multivitamin with at least 100 mcg B12.
As soon as I take my blood pressure meds, I get tired and lack energy for the rest of the day. What gives?I'm 77 and have Sjögren's syndrome. Can I take carnitine? How much should I take?Are there cardiac side effects to berberine? Both my husband and I take it for blood sugar.What types of protein are most helpful for osteoporosis and weight gain?The coronary artery inflammation controversy
Autonomous Artificial Intelligence (AI) and the future of medicineAre there any alternative ways to lower my blood pressure other than taking prescription medication?
On this week's episode of the WHOOP Podcast Science of Human Performance Series, WHOOP SVP of Research Algorithms and Data, Emily Capodilupo, sits down with WHOOP AVP Medical Director, Dr. Dan Henderson to discuss the key longevity habits to help you boost your healthspan and improve your WHOOP age. Emily and Dr. Henderson break down the difference between lifespan and healthspan, illustrating why decline with age isn't necessarily inevitable. The two break down how everyday choices around sleep, exercise, nutrition, stress, and social connection can compound over time to shape how we age. This episode clarifies the habits with the greatest impact on long-term health, why many popular longevity supplements may offer less benefit than advertised, and how biomarkers and blood testing can uncover hidden opportunities to improve both health and performance. Emily and Dr. Dan explain how WHOOP Advanced Labs and WHOOP Age can help people better understand their individual health and take practical steps today to extend their healthspan to feel better for years to come.(01:25) Healthspan vs. Lifespan(03:03) Is Aging Decline Inevitable? (04:51) The Habits and Biomarkers For Healthy Aging(08:55) The Lifestyle Choices That Reduce Biological Age(11:10) Does Stress Make You Age? (13:03) Important Health Benefits of Social Connection(14:17) What Supplements Should You Actually Be Taking? (19:30) What Lab Results Can Tell You About How You Age(28:42) Cardiac Health: Preventing Heart Health Risks(28:02) Weight Management and Insulin Resistance(32:00) How Sleep Impacts Aging(39:05) Root Cause Health Issues (And How To Avoid Them)(41:09) How To Lower Your WHOOP Age Support the showFollow WHOOP:Sign up for WHOOP Advanced LabsTrial WHOOP for Freewww.whoop.comInstagramTikTokYouTubeXFacebookLinkedInFollow Will Ahmed:InstagramXLinkedInFollow Kristen Holmes:InstagramLinkedInBuy Aligned by Dr. Kristen Holmes: Follow Emily Capodilupo:LinkedIn
Dr. Hoffman continues his conversation with functional medicine practitioner Robert Rountree, MD, medical director of Boulder Wellcare, in Boulder, Colorado, and long-time educator at the Institute for Functional Medicine.
Innate–Adaptive Balance and BWH 85 Beta-Glucan with Functional Medicine Physician Dr. Rob Rountree: He brings a nuanced view of immunity that rejects the simple “immune boosting” dimmer-switch model and emphasizes immune regulation and readiness. He reviews innate immunity as sentinel cells using pattern recognition receptors (e.g., macrophages) and explains how innate and adaptive systems interface, with innate signaling training adaptive responses; chronic inflammatory disease is framed as rooted in innate dysregulation. He reveals how immune responses can both protect and harm (candida, cytokine storm concerns during COVID) and why test-tube “stimulation” doesn't equal human effects. The focus is a purified brewer's yeast (Saccharomyces cerevisiae) beta-1,3/1,6-glucan (BWH 85, 85% purity), its triple-helix structure, receptors (Dectin-1, CR3), dosing (100–500 mg), evidence for improving vaccine response in elders, and potential relevance for autoimmunity, athletes, and cancer surveillance alongside lifestyle and key nutrients like vitamins A, C, D and zinc.
Hey everyone, and welcome to another episode of The Cultural Hall! I'm really excited about this one because we are finally solving a mystery. A couple of months ago, I told you all a story about DJing a wedding at a house that had some very unique door handles—exact replicas of the ones on the Salt Lake Temple. Well, the secret is out! It was the home of Brad and Marjorie Lowder (Marjorie is the youngest daughter of President Russell M. Nelson). I’ve been providing DJ services to the Daybreak community generally for ten years now, along with countless other spots across the state, but DJing that wedding at the Lowders’ house was an unforgettable highlight. Today, Brad and his twin brother Carris join me to talk about a brand new project they've started. After surviving a minor heart attack at 58 and losing his own dad at 67, Brad hit his 68th birthday and had a huge wake-up call. He did the math and realized he needed to make some serious lifestyle changes if he wants to be around to dance at his three-year-old granddaughter's wedding. To keep himself accountable, he and Carris launched a new podcast called Live Longer, Live Stronger. In this episode, we dive into: The Wake-Up Call: Brad's realization that he needed to overhaul his daily habits to make it to 93. Healthspan vs. Lifespan: Why it’s not just about adding years to your life, but making sure you have the mobility and health to actually enjoy them. Lessons from a Centenarian: The incredible example of longevity and purposeful living set by President Nelson, from his habit of always taking the stairs to his focus on daily movement. The Power of Purpose: Why simple things like serving others, staying connected with family, and having a reason to get out of bed are the true secrets to aging well. No Snake Oil: Why their new show isn’t about selling supplements or being preachy—it’s just a couple of guys sharing what they are learning along the way. This conversation is a fantastic reminder that we only get one body, and it's up to us to be good stewards of it. Take a listen, and let me know what you think! The post Live Longer Live Stronger – 1068 appeared first on The Cultural Hall Podcast.
Dr. Hoffman continues his conversation with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Incorporated, maker of Dr. Ohhira's premium probiotic products.
Dr. Ross Pelton, Director of Science & Education for Essential Formulas Incorporated, maker of Dr. Ohhira's premium probiotic products, reveals how the gut microbiome affects metabolism, appetite, weight regulation, and overall health. He emphasizes the importance of microbiome diversity, supported by eating a wide variety of plant foods rich in fiber and polyphenols, and discusses how fermented foods and postbiotic metabolites help maintain a healthy gut environment. Pelton explains Dr. Ohhira's multi-year fermentation process and the idea that postbiotics may be key health regulators. He reviews studies suggesting benefits from Dr. Ohhira's probiotics for athletic performance markers, reduced fatigue, and improved bowel regularity, and notes research showing antibiotic-related losses in gut diversity can persist for years. He also mentions a higher-dose “Reset Challenge,” a postbiotic paste concentrate, and an ME-3 product aimed at increasing glutathione.
Show notes: (0:00) Intro (1:04) Dr. Srini Pillay's journey from South Africa to Harvard and brain research (4:50) Why the brain and body should be viewed as one connected system (9:32) Emotional suppression, vitality, and physical health (12:35) Why your brain needs periods of unfocused thinking (15:40) Mindsets linked to inflammation, health, and longevity (18:24) Burnout, vitality, and discovering your ideal self (21:06) Autonomy, relationships, motivation, and living longer (23:16) Growth mindset and training your brain to see possibilities (25:30) How beliefs and expectations can change the brain (27:29) Optimism, awe, connection, resilience, and self-transcendence (29:43) Changing your identity to improve creativity and problem-solving (31:37) Visualization and the science behind the law of attraction (35:30) Rewriting the story of your past (39:02) How hostility and stress may affect the body (41:50) The CIRCA method for calming stress and anxiety (46:12) Walking, napping, daydreaming, and doodling for better thinking (48:09) Why understanding your ideal self may be the most important step (48:57) Where to follow Dr. Srini Pillay and learn more (50:48) Outro Who is Dr. Srini Pillay? Dr. Srini Pillay is a Harvard-trained psychiatrist, brain researcher, author, executive coach, and technology entrepreneur whose work focuses on the connection between mindset, brain health, performance, and longevity. He completed his psychiatry residency at McLean Hospital and spent 17 years conducting brain-imaging research, while also directing programs focused on anxiety and panic disorders. He formerly served as an Assistant Professor of Psychiatry at Harvard Medical School. Today, Dr. Pillay is Chief Medical Officer and Co-Founder of Reulay, an AI-driven digital therapeutics company, and Founder and CEO of NeuroBusiness Group. His current work explores psychogenic longevity, including how thoughts, emotions, stress, and mindset may influence healthspan and well-being. He is also the author of Life Unlocked, Your Brain and Business, and Tinker Dabble Doodle Try, and has worked with leaders and organizations around the world. Connect with Dr. Srini: Website: https://drsrinipillay.com/ LinkedIn: https://www.linkedin.com/in/drsrinipillay IG: https://www.instagram.com/drsrinipillay/ FB: https://www.facebook.com/SriniPillayMD/ Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram
Paying attention to injuries may speed healing—could pain meds blunt the healing response? Fact check: “Everyone over 70 should take a statin”? Billy Joel's “brain surgery”; How to live past 100—get condemned to “death row”; Are vegans hotter than meat eaters? Promising lp(a) drug fails crucial test; Pain under the left rib cage—what are the possibilities?
Wobbly arms and shaky legs—could it be FND? Women who start hormones in the 50s have 23% lower dementia risk; How to prep for cataract surgery; Plant-based meat alternatives may deliver harmful mycotoxins; Keto diets outperform low-fat and Mediterranean diets for liver health, blood sugar; NY Times highlights magnesium for sleep; Even a single bout of antibiotics produces long-term harm to microbiome.
Could your heart, brain and kidneys all be aging at different rates?In this episode of Live Long, Peter Bowes talks with Paul Coletta, co-founder and CEO of Vero Bioscience, about the emerging science of organ-specific biological aging. Researchers at Stanford have been studying whether proteins in the blood can help estimate how quickly individual organs are aging and whether that information could reveal future health risks before disease develops.Paul explains how proteomics, machine learning and organ-age clocks work, and why an unexpected result from his own kidney-age test helped draw him into the field. The conversation also explores the limits of biological-age testing, the risk of over-testing and health anxiety, and whether knowing your “weakest link” can genuinely help guide lifestyle changes or preventive care.We also discuss healthspan, sleep, sunlight, self-experimentation, emerging longevity interventions and the difference between extending life and extending the number of healthy years we live.Context for this episodeThe personal health practices, supplement choices and off-label therapeutic protocols discussed by Paul Coletta in this episode represent his own monitored “N-of-1” experiments. They are shared strictly for informational and educational purposes and do not constitute medical advice or endorsement.Individual responses to supplements, medications and lifestyle interventions can vary, and what is appropriate for one person may not be suitable for another. Some interventions may also carry risks, interact with medications, or require medical monitoring.Always consult your primary care physician or another qualified healthcare professional before making significant changes to your diet or health practices, or before starting new supplements or medications.Support the podcast: We've brought together special offers and discounts on products that could help you live a longer, healthier life. When you buy through our partner links, you help support the Live Long podcast and keep our content free for everyone.Click here to start shopping with our sincere thanks. EnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
Nutritionist Leyla Muedin answers a listener question about taking many supplements with oolong tea, explaining that tea tannins can interfere with vitamin and mineral absorption; because oolong is partially oxidized, its tannin level falls between green and black tea, so she recommends taking supplements with water and separating them from tea or coffee by at least an hour (ideally 1.5–2 hours). She then reviews research in Nature Communications from USC on how gut signals via the vagus nerve may influence which food experiences become memories: in rats, nutrient-rich foods increased acetylcholine signaling to the hippocampus, supporting memory for food location, while sweetness without calories did not. Over time, high-fat/high-sugar diets weakened this gut–hippocampus communication and memory performance, with implications for obesity, diabetes/prediabetes, and cognitive decline, and possible future vagus-nerve-based approaches.
The body you'll live in 10, 20, or even 30 years from now is being built by the signals you send it today. Every workout, meal, night of sleep, stressful moment, and meaningful connection is part of an ongoing biological conversation—one that shapes your future strength, energy, metabolism, resilience, and ability to keep participating fully in the life you love.In this powerful episode, Dr. Thomas Hemingway reveals why you are always training your body for something, whether you realize it or not. You'll discover the seven essential signals influencing who you are becoming, why muscle and cardiovascular fitness function like retirement accounts for your future body, and how small, consistent choices can preserve possibility for decades to come. You'll also receive a simple seven-day experiment to begin changing your signals—without perfection, overwhelm, or another complicated health routine. Your future self is listening. What will you tell them today?Please SHARE with a Friend!**Free PDF: "How to get the Health and Life that you Want, by doing this now" Inside the PDF, we share how to partner with your biology instead of fighting it. These questions will help you change your signals, your biology and your life, one day at a time.*And, in my new Performance, and Longevity medical practice we specialize in turning back your biological age and OPTIMIZING HORMONES so you can feel a decade or more younger so you can do the things you want to do that you thought were no longer possible due to your age. Join the waitlist here!*Don't wait to Prioritize your health, Start Today with the Simple and Powerful Steps detailed in my Best-selling book, PREVENTABLE.*ACCESS my FREE workshop, "GET 10 Years Younger, Stronger, and Sharper" How to turn back your biological age 10-20 years so you can do the things you want to do that you no longer thought possible due to your age. Perform at your best and live your best life!Join my Free Masterclass on Midlife Hormones, "Why You Don't Feel like Yourself anymore and What to Do about it!"JET LAG Survival Guide. Free PDF!*GET DIRECT ACCESS to DR. HEMINGWAY in these AMAZING COURSES!**Free Resource: "The 7 lab tests your doctor likely is not checking and could be the key to why you don't feel your best." *Don't Forget to SHARE with a Friend and please drop a Review:) It means the world!Mahalo and Aloha andTo your health,
How can I find an integrative pediatrician in the NYC or Weehawken/Hoboken area?Can the xylitol in my nasal spray have an adverse impact on heart health?I chronically use Vaseline on my lips. Is this a concern?My 25-year-old daughter was diagnosed with lipedema stage one. Any advice?I had an Apo B test and am confused at the results. Could you elucidate?
Ultra-processed foods' impact on postpartum depression/psychosisWhich should my sister take, Jardiance or Dapagliflozen? I had aortic valve repair. Can I safely take N101?I suffer with trigeminal neuralgia after recent extensive dental work. What do you advise?What would be the optimal total testosterone level for an 84 year old male?
Is longevity becoming one of the next major growth industries in health and wellness?On this episode of The Travel Wins Podcast, I sit down with Scott Crosbie of Next Health Nashville to discuss his journey into the longevity business, what he has learned so far, the rapid growth surrounding health optimization, and why more people are becoming interested in taking a proactive approach to their health.Scott's journey into longevity became deeply personal after his mother's experience with dementia led him to explore health optimization and the possibilities surrounding living healthier for longer.We talk about the evolution of the longevity industry, the growing consumer interest in preventative health and healthspan, and what Scott has learned as an entrepreneur building Next Health's presence in Nashville.Our conversation comes at the perfect time.On Saturday, September 12, 2026, Scott and Kim Crosbie are helping host the Next Health Longevity Summit at the Conrad Nashville, bringing together leading voices in longevity, preventative medicine, performance and wellness.In this episode:• Scott Crosbie's journey into the longevity business• How a personal family experience changed his perspective on health• Why longevity and healthspan are attracting so much attention• The rapid growth of the longevity industry• Building Next Health in Nashville• Health optimization and preventative wellness• The business opportunities emerging around longevity• Why personal health data is becoming increasingly important• The future of longevity and personalized healthcare• The Next Health Longevity Summit in Nashville• Why business travelers should think differently about their long-term healthWhether you're an entrepreneur, executive, frequent business traveler or simply interested in living a healthier life, this conversation offers an interesting look inside one of today's fastest-evolving areas of health and wellness.
Dr. Hoffman continues his conversation with integrative medicine physician, board-certified internist, and researcher Dr. Jacob Teitelbaum about his new book, "Pain Relief in 4 Simple Steps."
Renowned integrative medicine physician, board-certified internist, and researcher Dr. Jacob Teitelbaum discusses his new book, "Pain Relief in 4 Simple Steps," and the growing chronic pain epidemic (one in four U.S. adults; about 7% debilitating). Teitelbaum argues most pain is treatable by addressing root causes and describes four biochemical pain types—muscle pain from low energy, inflammatory pain, neuropathic pain, and brain pain (microglial activation)—alongside structural, biophysical, and mind-body contributors. They discuss risks of NSAIDs and Tylenol, diet's role (processed foods, sugar, seed oils), and strategies such as an Energy Revitalization Drink Mix, SHINE protocol, curcumin with turmeric oils plus boswellia (Curamin), omega-3 support, magnesium, B12 issues with metformin/GLP drugs, lipoic acid for neuropathy and burning mouth syndrome, and migraine support with high-dose riboflavin and magnesium. He also cover CRPS treatments (including ketamine and bisphosphonates), low-dose naltrexone and PEA, compounded topical options, and pelvic pain/prostatitis approaches including quercetin and antibiotics like fosfomycin when appropriate.
New study attempts to resolve question over which has contributed more to our current obesity epidemic—diet or sedentary lifestyle? Pros/cons of CT scans vs. MRIs for investigating abdominal complaints; Fish oil rivals effectiveness of antibiotics for periodontal disease; The MIND diet vs. KetoFLEX Diet for fending off cognitive decline; Vitamin B3 helps relieve Raynaud's symptoms; After American Heart Association green lights coffee, new study shows high consumption can accelerate bone loss; High-dose vitamin D protects memory in light sleepers.
This Week In Startups is made possible by: Odoo - http://Odoo.com/twist Northwest Registered Agent - https://www.northwestregisteredagent.com/twistdomain Rippling - http://Rippling.ai/twist Today's show: Your doctor almost certainly isn't testing your insulin. Dr. Mark Hyman sits down with Jason to explain the broken system that Function is fixing, and what 100 million biomarkers say about how sick America actually is. Learn why insulin beats blood sugar as an early warning for TKTKTK. Why might "normal" lab ranges be unreliable? PLUS, how does an expert like Dr. Hyman feel about GLP-1s and psychedelics? Guests: Dr. Mark Hyman on X: https://x.com/drmarkhyman Function: https://www.functionhealth.com/ Relevant Links: The Dr. Hyman Show — https://podcasts.apple.com/us/podcast/the-dr-hyman-show/id1382804627 Function pricing — https://www.functionhealth.com/pricing Ezra — the full-body MRI company Function acquired https://ezra.com/ Galleri (GRAIL) — the multi-cancer early detection blood test — https://www.galleri.com/ Tufts / JACC study — the source of the "93% of Americans have metabolic dysfunction" — https://now.tufts.edu/2022/07/05/only-7-american-adults-have-good-cardiometabolic-health American College of Cardiology — https://www.acc.org/ Dr. Jorge Plutzky — https://www.health.harvard.edu/authors/jorge-plutzky-md OpenEvidence — https://www.openevidence.com/ Stanford Metabolic Psychiatry Clinic — https://med.stanford.edu/news/all-news/2022/11/metabolic-psychiatry.html Stanford Medicine on the ibogaine findings → https://med.stanford.edu/news/all-news/2024/01/ibogaine-ptsd.html Texas SB 2308 — the $50M state investment in ibogaine trials — https://www.texastribune.org/2026/03/31/texas-ibogaine-research-clinical-trials-psychedelics/ Timestamps: 0:00 What Function actually is 6:43 Healthspan vs. sick care 10:16 Odoo - The all-in-one business platform. Your first app is free! Get started today at https://Odoo.com/twist 11:32 A $300 vitamin D test vs. a $10 one 18:08 Should a 25-year-old get a whole-body MRI? 20:42 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.com/twistdomain 24:23 Why medicine is still running on paper 25:41 The study where the chatbot beat the doctors 27:02 micro1, doctors in the loop, and why AI still needs guardrails 28:50 Wearables, records, and the CD-ROM problem 30:07 Rippling - Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 32:51 The wearable that caught Jason's Covid 34:31 Alcohol, sugar, and why almost nobody tests your insulin 40:00 GLP-1s: Jason's 213-to-168 story 42:22 Microdosing GLP-1s, muscle loss, and "skinny fat" 48:48 Overdiagnosing mental illness: SSRIs, Adderall, and a lost decade 50:17 The biology underneath depression and anxiety 54:32 Psychedelics: ketamine, ibogaine, and the second revolution in psychiatry Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason's suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com
How we respond to stress and emotions can have a powerful impact on our relationships, health, and longevity. In this episode, I'm joined by psychologist and author Elisha Goldstein as we discuss making “Tiny Shifts” that help us recognize emotional patterns, regulate our nervous system, shift our perspective, and respond more intentionally. We talk about why emotional regulation is a skill we can practice, how small changes can create lasting impact, and simple tools for navigating stress, relationships, parenting, and everyday life. → Leave Us A Voice Message! Sponsored By: → Timeline | Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $79, when you subscribe at https://timeline.com/KELLY → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com → Fatty 15 | Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/KELLY15 and using code KELLY15 at checkout. Timestamps: → 00:00:00 - Introduction → 00:02:10 - Childhood, Self Worth & Psychology → 00:05:48 - Emotional Regulation & Leadership → 00:09:08 - Breaking Emotional Patterns → 00:15:18 - How to Recognize Emotional Triggers → 00:17:40 - Nervous System & Body Signals → 00:20:34 - Breaking the Overwhelm Loop → 00:25:24 - Shifting From Stress to Gratitude → 00:28:00 - Work Life Balance & Stress → 00:32:00 - How Relationships Shape Us → 00:38:18 - Nervous System Regulation Tools → 00:40:48 - Refocusing Your Thoughts → 00:43:10 - Emotional Regulation in Parenting → 00:48:28 - Stress, Healthspan & Longevity → 00:53:02 - Relationships & Longevity → 00:58:40 - Fear & Relationship Conflict → 01:04:36 - Modeling Healthy Emotions for Kids → 01:08:16 - Where to Find Elisha Goldstein Further Listening: → Why You Keep Overreacting + How to Regulate Your Nervous System | Jonny Miller Check Out Elisha Goldstein: → Website → Instagram → Tiny Shifts Book Check Out Kelly: → Instagram → Sweet Deal (Book) → Youtube → Facebook