Podcasts about Fasting

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. You'll Learn: Why microplastics accumulate inside lysosomes and what sulforaphane does to release them How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin What an in-house study revealed about how and where microplastics actually leave the body How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch How sulforaphane boosts BDNF and neuroplasticity at the cellular level What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox Resources: • For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:55 – Intro & Context 4:48 – Microplastics & Sulforaphane 12:39 – Broccoli Sprouts Formulation 15:20 – Lab Origin Story 26:01 – Reducing Toxin Exposure 37:06 – Estrogen, Hormones & Berberine 52:46 – Autism, ADHD & Brain Health 59:01 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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You're not imagining your fibromyalgia pain or symptoms. Discover common fibromyalgia causes and triggers, and learn how to find fibromyalgia relief by addressing the underlying issue.0:00 Introduction: Fibromyalgia explained 0:42 Fibromyalgia causes and triggers 1:45 Low vitamin D and fibromyalgia3:19 Mitochondrial damage and fibromyalgia symptoms5:00 What to do for fibromyalgia relief5:31 Fibromyalgia research and recovery7:58 Fixing low vitamin D 8:39 Magnesium deficiency and fibromyalgia symptoms 10:34 More fibromyalgia relief tips

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Matthew 6:16-18 - Jesus concludes the middle section of the sermon with a discussion of the last of 3 spiritual practices: fasting. Again, Jesus emphasizes the heart posture of the one who fasts, reminding us that the true purpose is to commune with God. Fasting—"a Christian's voluntary abstinence from food for spiritual purposes"—engages the whole person (body, spirit, desires and on and on) in a way that few other disciplines do. In this teaching we receive an invitation to fast as Jesus envisions, not to earn our favor with God, but to respond to His grace with our whole selves. A sermon by Cameron Heger. [Part 16 of our series “Jesus's Sermon on the Mount: The Good Life in the Kingdom of Grace”]

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Long before church history became filled with councils, creeds, and formal traditions, early Christians were already learning how to live as faithful followers of Jesus.In this episode of Kitchen Table Theology, Pastor Jeff Cranston and Tiffany introduce the Didache, one of the most important early Christian writings outside the New Testament. They explain how this ancient document helps us understand the worship, discipleship, church practices, and spiritual priorities of believers in the first generations of the church.Chapters:01:20 What Is the Didache?The Didache is one of the most important early Christian writings outside the New Testament. Its name means “teaching,” and its full title presents it as instruction passed from the Lord through the apostles to the Gentile church.03:00 Was the Didache Written by the Apostles?The Didache was likely not written directly by the apostles, but it was compiled very early in church history. It functions like an early church handbook for Christian living, worship, and church practice.05:30 How the Didache Was Lost and RediscoveredThe Didache was highly valued by early Christians, but it was not included in the New Testament canon because it was not apostolic Scripture. After disappearing for centuries, it was rediscovered in 1873.07:30 The Four Main Sections of the DidacheThe Didache is organized around four major themes: the way of life and the way of death, instructions for baptism, fasting, and communion, guidance for handling traveling teachers, and a final call to live ready for Christ's return.08:30 The Two Ways: Life and Death The Didache begins by presenting two paths, the way of life and the way of death. This theme echoes Scripture's call to choose the narrow way that leads to life, reminding believers that discipleship includes both right belief and faithful obedience.11:15 Baptism, Fasting, and Holy Preparation The Didache gives practical instructions for baptism in the name of the Father, Son, and Holy Spirit while allowing flexibility in how it is practiced. It also connects baptism with fasting, showing that the early church treated baptism with seriousness, reverence, and spiritual preparation.14:15 Communion, Worship, and Reconciliation The Didache presents simple instructions for communion and Sunday worship, including thanksgiving, confession of sin, and gathering together as the church. It also emphasizes reconciliation before worship, reminding believers that repentance and worship belong together.19:15 Living Ready for Christ's Return The Didache ends with a call to watchfulness and faithfulness in light of Christ's return. Though it is not Scripture, it remains a valuable witness to how early Christians practiced apostolic teaching through worship, holiness, repentance, hope, and faithful obedience.“It might be an ancient document, but its call to us is fresh. Follow Christ seriously, joyfully, and together.” - Pastor Jeff Cranston

Neil McClendon, Lead PastorGrand Parkway Baptist ChurchWhy New is Better Than BetterMatthew 9:14-171. Jesus came to be enjoyed, v. 15aQ. 1. What is the chief end of man?A. 1 Man's chief end is to glorify God, and to enjoy Him forever.Matthew 11:16-192. Fasting is an expression of lament and longing, v. 14-15Psalm 13Four questions to restore your perspective...a. What am I trusting in?b. What am I rejoicing over?c. What am I singing?d. What am I remembering?3. Jesus came to bring new not better, v. 16-17Romans 6:1-4Revelation 21:1-5Mental worship...1. Is your problem that you sin too much or that you don't enjoy God enough?2. Who or what do you most often turn to when you get tired of waiting on God?3. Who in your life is tired of your efforts to get better?4. What are you trusting in, rejoicing over, singing and remembering?5. Where do you need to replace better with new?Be sure to follow us:InstagramFacebookYoutube

What is the purpose of fasting, and why did Jesus expect His followers to practice it? In this message, Pastor Korey explores Matthew 6:16–18 and shows that fasting is far more than going without food—it is a physical expression of spiritual dependence. Looking at examples throughout Scripture, we see God's people fasting to seek wisdom, guidance, mercy, protection, and a deeper relationship with Him. Fasting reminds us that our greatest need is not what sustains our bodies, but the God who sustains our lives.

The weekly podcast of Empowerment Ministries Christian Center, led by Dr. Gregg S. Magee, Sr.

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Tara breaks down the top five hidden blocks to better body composition—low deep sleep and under‑recovery, poor insulin sensitivity, not enough muscle, overeating "healthy" fats, and the "I come last" mindset—plus practical fixes you can start using right away.   RESOURCES: Learn more about Tara here: http://taragarrison.com Instagram: @coachtaragarrison @higher.coaching Get 10% off Peluva minimalist shoe with coupon code COACHTARA here: http://peluva.com/coachtara   CHAPTERS: 00:00 – Solo intro: 5 biggest body comp blocks 00:45 – Sponsor: Peluva minimalist shoe ad 02:31 – Block #1: Under‑recovery and low deep sleep 07:00 – Fixing deep sleep: stress, nervous system, rituals 12:04 – Sleep environment: cool, dark, quiet room tweaks 13:31 – Night wakings, blood sugar drops, CGM insights 15:37 – Perimenopause, HRT and better sleep 21:40 – Block #2: Insulin resistance and labs that matter 27:33 – Fasting insulin ranges and getting more sensitive 34:23 – Block #3: Not enough muscle mass (why it matters) 41:31 – How to actually build more muscle and recover 41:57 – Block #4: "Eating healthy" but way too much fat 49:28 – Block #5: "I come last" mindset and boundaries 51:51 – Missing piece: fun, joy, play as real health    WORK WITH TARA: Are You Looking for Help on Your Wellness Journey? Here's how Tara can help you: TRY TARA'S APP FOR FREE: http://taragarrison.com/app INDIVIDUAL ONLINE COACHING: https://www.taragarrison.com/work-with-me CHECK OUT HIGHER RETREATS: https://www.taragarrison.com/retreats   SOCIAL MEDIA:  Instagram @coachtaragarrison TikTok @coachtaragarrison Facebook @coachtaragarrison Pinterest @coachtaragarrison   INSIDE OUT HEALTH PODCAST SPECIAL OFFERS: ☑️ Upgraded Formulas Hair Test Kit Special Offer: https://bit.ly/3YdMn4Z ☑️ Upgraded Formulas - Get 15% OFF Everything with Coupon Code INSIDEOUT15: https://upgradedformulas.com/INSIDEOUT15 ☑️ Rep Provisions: Vote for the future of food with your dollar! And enjoy a 15% discount while you're at it with Coupon Code COACHTARA: https://bit.ly/3dD4ZSv

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“Why did the Church end weekly fasting?” This question opens a discussion on the evolution of Church practices, alongside inquiries about the Church’s stance on jousting, the concept of limbo for infants, and the pastoral duties of priests. These topics reflect the diverse concerns and curiosities within the Catholic faith today. Join the Catholic Answers Live Club Newsletter Invite our apologists to speak at your parish! Visit Catholicanswersspeakers.com Questions Covered: 02:50 – Why Did the church kill off weekly fasting? 08:00 – I have heard the Church banned jousting. Does that mean we can't do that at Medieval Times? 13:27 – Is it acceptable for Catholics to believe in the limbo of the infants? 19:13 – How do I articulate the Catholic position that it is not faith alone that saves, without sounding like our works save us? 28:00 – Modeling Jesus in Dating Before Marriage 34:36 – I've been going through some ongoing stalking, hacking, and financial fraud. I thought I could go to the Church for help but they don't seem to be able to offer me support. What are the pastoral duties of a priest? I've been thinking of leaving the Catholic Church because of this. 43:54 – Why is it the norm in the US to receive communion in the hand and standing? Why did it change from what seems to be a more reverent posture? 48:09 – How can the Church hold up Mary and Joseph as an ideal marriage, when they did not consummate and therefore it would not have had a sacramental marriage? 51:23 – When should you leave your parish for another parish based on your priest teaching false things? My priest is very loving and kind, but is not on board with some doctrines and some sexual teaching of the Church?

Dr. Jason Fung is a Canadian nephrologist, New York Times bestselling author, and leading voice in the fields of intermittent fasting, insulin resistance, weight loss, and type 2 diabetes. He is best known for his books The Obesity Code, The Diabetes Code, The Complete Guide to Fasting, and The Hunger Code, where he challenges the traditional “calories in, calories out” model and argues that hormones, especially insulin, play a major role in fat storage, hunger, and metabolic health. Dr. Fung co-founded The Fasting Method and has helped popularize fasting as a practical tool for improving metabolic health and supporting sustainable weight loss. Today on the show we discuss: why losing body fat is more complicated than calories in versus calories out, how hormones like insulin and cortisol affect fat storage, why ultra-processed foods can drive hunger and cravings, how emotional eating and habit-based eating keep people stuck, why fasting works best when paired with better food choices, and the simple daily habits that can improve insulin control, including whole foods, fewer refined carbs, walking after meals, better sleep, and stress management and much more. Today's sponsor: Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to https://www.fatty15.com/DOUG and using code DOUG at checkout ⚠ WELLNESS DISCLAIMER ⚠ Please be advised; the topics related to health and mental health in my content are for informational, discussion, and entertainment purposes only. The content is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek the advice of your health or mental health professional or other qualified health provider with any questions you may have regarding your current condition. Never disregard professional advice or delay in seeking it because of something you have heard from your favorite creator, on social media, or shared within content you've consumed. If you are in crisis or you think you may have an emergency, call your doctor or 911 immediately. If you do not have a health professional who is able to assist you, use these resources to find help: Emergency Medical Services—911 If the situation is potentially life-threatening, get immediate emergency assistance by calling 911, available 24 hours a day. National Suicide Prevention Lifeline, 1-800-273-TALK (8255) or https://suicidepreventionlifeline.org. SAMHSA addiction and mental health treatment Referral Helpline, 1-877-SAMHSA7 (1-877-726-4727) and https://www.samhsa.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

GLP-1 medications are changing the conversation around weight loss, metabolism, and women's health. But are we asking the right questions about long-term health?In this solo episode, Dr. Mindy Pelz breaks down the science behind GLP-1 drugs like Ozempic, Wegovy, and Mounjaro, including what they do well, where concerns are emerging, and how fasting mimics many of the same metabolic benefits naturally.Dr. Mindy explores: • The connection between GLP-1 drugs and muscle loss • Why women over 40 need to think differently about metabolism • New research linking GLP-1s to declining bone density • How fasting impacts glucagon, ketones, and fat burning • The importance of protein, refeeding, and resistance training • Why metabolic flexibility matters more than rapid weight loss • Natural ways to stimulate your body's own GLP-1 productionThis episode is not about fear or shame. It's about helping you understand your options so you can make informed decisions for your body, your hormones, and your long-term health.For more resources related to today's episode, visit the podcast episode page: https://www.drmindypelz.com/ep341Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

Episodes Mentioned:The Frequency of Holy Spirit: https://youtu.be/8MjQyNXorJU?si=BJcE65kLDA-BWdLUHearing God Practically: https://youtu.be/6TSHXI79QEg?si=SnhL1_613FD5DlvDMissing God's Voice: https://youtu.be/t4To04ifTRU?si=FWLhVEaXUZr9nMC9Manifestation: https://youtu.be/Ap4wBQWVSSg?si=ojJhpT47J-5kympoGo Deeper on Topics From the Showhttp://www.novosnetwork.com/kairosDeep End Websitehttps://deependtv.com/Get Weekly UpdatesText "TAW" to 615-845-5977Taylor's Websitehttps://taylorawelch.com/Twitter: https://twitter.com/taylorawelchInstagram: https://www.instagram.com/@taylorawelchFacebook: https://www.facebook.com/taylorawelchprofileTikTok: https://www.tiktok.com/@taylorawelchFull Deep End Playlist: https://youtube.com/playlist?list=PLsJLC9JVAX745VhRtK7BsoBWKXF0yVrsB&si=YqkT8lg5eFell2o3Listen to The Deep EndApple Podcasts: https://podcasts.apple.com/us/podcast/the-deep-end-w-taylor-welch/id1500492987Spotify: https://open.spotify.com/show/3Pqrl9Xpuja6kSPjHUgxF4?si=0e673cd31d5d4217BIO:Taylor Welch is an investor & business consultant. His portfolio of companies have serviced over 50,000 individual small businesses in the last 5 years. He currently lives in Nashville Tennessee with his wife and 2 kidsCHAPTERS:1:30 Start4:15 Is God Real?15:22 Does God Care?21:25 Fasting and Disobedience30:05 Cost of Following God30:55 Giving Away the Companies33:24 Hearing God Audibly40:05 Suicidal Spiral Explained47:48 FTC Investigation Pressure52:43 Talking to God 59:29 Learning to Hear God1:03:44 Airport Test and Vision1:16:03 New Problems Following God1:24:03 Tribe Reputation Tension1:26:07 Why Spiritual Hunger Surges1:35:24 Counterfeit Revival1:39:03 Beyond "Fire Insurance"1:49:27 Messy Church And Microbiome1:52:28 Biosphere Trees Need Wind1:56:07 Negotiating With God1:58:32 Discipline And Trust2:07:13 God Trusts The Messy2:10:37 Tuning Your Appetite2:20:37 Blessing Through Correction2:26:10 Prayer

Some Christian authors describe fasting as the most feared and misunderstood discipline, and perhaps the least practiced in the Christian church. Why? What stops Christians from fasting?Listen in as James walks us through a definition of Christian fasting as well as why and how to engage in fasting as parents. Like all spiritual disciplines or ordinary means of God's grace, through fasting, Christians engage Scriptural patterns with the aim to become more like Jesus.1 Tim. 4:7-10. “[Discipline] yourself for godliness; for while bodily training is of some value, godliness is of value in every way, as it holds promise for the present life and also for the life to come . . . because we have our hope set on the living God, who is the Savior of all people, especially of those who believe.”“There is no virtue in fallen man by which he can make himself more godly; thereis, however, virtue in the divinely appointed means of grace. If we, by the powerof the Holy Spirit, mortify the deeds of the body (through fasting), we shall growin grace, but the glory of such change will be God's alone.” David Smith.John Calvin: “since fasting is a holy exercise both for the humbling ofmen and for their confession of humility why should we use it less thanthe ancients did in similar need?”

Most people pair apostles with prophets, pastors with teachers. Acts 13 verse 1 puts prophets and teachers in the same room — and uses them together to change the history of the church. Pastor Scott Ethridge and Carlos Renfroe dig into why that combination matters more than we've been taught. --- Connect With The Healing Place Website: www.thpshreveport.com  Questions or prayer requests: mediahub@thpshreveport.com Midweek Move is the podcast extension of The Healing Place, Shreveport, LA — where we examine the scriptures in context and ask: "What is happening here?" ___ 0:00 — Cold open: "Prophets and teachers together. Really?" 0:21 — Welcome + Acts 13 intro; why this chapter matters 1:12 — Acts 13:1–3 read aloud by Carlos; the unusual pairing of prophets and teachers 2:16 — Breaking down the leaders: Simeon called Niger, Lucius, Manaen (who grew up with Herod), Barnabas, Saul 3:36 — Manaen and Herod: same upbringing, completely different paths 4:05 — "They ministered to the Lord" — not to each other; what that distinction means 4:11 — Why prayer and fasting matters before major decisions 5:14 — Fasting as a denial of the flesh: "giving up something in the physical to receive something in the spiritual" 6:15 — The test that comes with fasting (the pork loin story) 7:40 — How a "no" during a fast becomes a supernatural response 8:01 — The church's posture toward the Holy Spirit's direction 9:07 — Acts 13:4–12: Barnabas and Saul sent out; they arrive at Salamis 9:43 — Sergius Paulus and Bar-Jesus (Elymas): a false prophet trying to block the true gospel 11:02 — Paul filled with the Spirit confronts Elymas — and why his response wasn't from the flesh 12:08 — Paul strikes Elymas blind; the proconsul believes 13:26 — "We never know who is listening" — the lesson from Paul's obedience 13:46 — Acts 13:13–52: preaching to the Jews first, then calling the Gentiles 14:21 — "Shaking the dust" — they're following Jesus, not the Law 14:40 — Persecution producing joy and the Holy Spirit 15:06 — The recurring theme: every attempt to stop the work of God multiplies it 15:50 — A real-world story from Nigeria: a non-believer refuses to denounce Christ after watching believers stand firm 16:36 — How God uses our response in difficulty, not just the difficulty itself 17:12 — Final thought: the Word of God grows and multiplies through what looks like opposition

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner. Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch. This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear. You'll Learn: Why everyone who is chronically sick has a low cortisol awakening response and what to do about it How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both The parasite epidemic in the U.S. and why standard testing misses most of it How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID Why synthetic B6 causes the very neuropathy it is supposed to fix, and what to take instead The cortisol, adrenaline, and blood pressure connection that explains "wired but tired" How progesterone stabilizes mast cells and why estrogen dominance fuels inflammation and reactivity Why Dave Asprey uses low-dose cortisol, dexamethasone, and modafinil as part of his daily performance stack The mold binders that actually work, and which popular ones can harm hypermobile people How nicotine at low doses blocks spike protein from ACE2 receptors and protects the brain What the MTHFR gene, methylation, and folic acid have to do with breast cancer, depression, and estrogen detox Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order. -Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it outDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Jessica Peatross, functional medicine, mast cell activation syndrome, histamine intolerance, long COVID brain fog, mold toxicity, chronic Lyme disease, parasite testing, low cortisol, cortisol awakening response, MTHFR methylation, B6 toxicity, P5P, folinic acid, estrogen dominance, progesterone therapy, spike protein reactivation, Epstein-Barr reactivation, POTS, wired but tired, Kill Bind Sweat, WellnessPlus, vaccine exemptions, mold binders, nicotine ACE2, adrenal insufficiency, RCCX gene Resources: • Go to https://drjessmd.com/ and use code ‘DRJESS' at checkout • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:33 – Releasing Medical License 03:21 – Chronic Illness Root Causes 05:00 – Hospital Nutrition 08:11 – Dave's Health History 10:22 – Parasites 20:02 – Nicotine 23:19 – Low Blood Pressure & Minerals 28:09 – B Vitamins & Methylation 33:45 – Autism & Genetics 40:13 – Toxic Mold 43:11 – ADHD Misdiagnosis 48:27 – Histamine & Mast Cells 50:56 – Long COVID & Spike Protein 58:56 – Cortisol 1:03:56 – Lyme Disease 1:09:58 – Mold Testing & Binders 1:16:37 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cancer care is evolving, and today's conversation with Martha Tettenborn dives into one of the most overlooked aspects of healing and prevention: metabolic health. Martha is a cancer survivor, author of Hacking Chemo, and currently works with Dietary Therapies, where she helps support patients using evidence-based nutritional and metabolic approaches alongside conventional cancer care. In this follow-up conversation, we move beyond Martha's personal story and explore what she's seeing firsthand in patients today. We discuss the growing connection between insulin resistance, blood sugar dysregulation, inflammation, and cancer progression — and why metabolic health deserves a much bigger place in the cancer conversation. Martha also shares practical insights into keto therapies, fasting during treatment, common mistakes patients make when trying these approaches on their own, and the importance of individualized care and professional guidance. This episode is not only valuable for those navigating cancer, but also for anyone struggling with fatigue, inflammation, insulin resistance, stubborn weight gain, or chronic metabolic dysfunction. So many of the foundational principles that support metabolic healing apply broadly to overall health and disease prevention. ✨ How Martha's perspective has evolved from cancer survivor to working directly with patients at Dietary Therapies ✨ Common metabolic patterns she is seeing in cancer patients today ✨ The connection between insulin resistance, blood sugar dysregulation, and cancer progression ✨ What people are misunderstanding about keto and fasting for cancer care ✨ Who may not be a good candidate for fasting during treatment ✨ The biggest mistakes people make when trying dietary therapies on their own ✨ How metabolic therapies can work alongside conventional oncology care ✨ Why nutrition and metabolic health are still often overlooked in cancer treatment ✨ Lifestyle habits and strategies that may support long-term healing and recurrence prevention ✨ Why metabolic health matters even for those who have never faced a cancer diagnosis LINKS & RESOURCES: Learn more about Martha's work through Dietary Therapies Get Martha's book Hacking Chemo READY TO IMPROVE YOUR METABOLIC HEALTH? ✨ My 90-Day COMPASS Reset begins Monday, June 1st! This guided reset is designed to help you stabilize blood sugar, improve energy, reduce inflammation, and begin healing your metabolism with sustainable strategies focused on meal timing, metabolic flexibility, circadian health, and nervous system support. The only requirement to join is being on the Feel Great System. Get started here: https://ufeelgreat.com/c/SHANAH

Ever look up and realise a whole month has vanished? This episode is about why that happens — and how to get more life out of the same amount of time. Most people think time speeds up because they're busy. Not quite. Time speeds up when your brain stops noticing. When your days are repetitive, distracted, and half-lived, your memory writes almost nothing down. That's why a week of scrolling disappears, while one difficult, vivid, meaningful afternoon can feel strangely rich. In this episode, I break down the psychology of time perception using examples from TikTok, procrastination, ADHD, novelty, and emotional reframing. The big idea: a full life isn't made from more hours. It's made from more moments that feel real. We talk about why discomfort often stretches time, why autopilot erases it, and how learning to stay with tension can make you calmer, sharper, and more alive. Add novelty on purpose: new places, new conversations, new experiences. Notice when you're escaping discomfort instead of living through it. Use memory as a metric: if nothing stands out, something needs to change. If time keeps slipping through your hands, this episode will help you hold it differently. UPGRADE to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Premium⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠:

Life moves faster than we realize. One day you blink, and years have passed. So what are we doing with the time God has given us?In this message, Pastor Brandon continues our Chasing Purpose series by looking at Solomon's final reflections in Ecclesiastes. After a life filled with wealth, influence, success, and regret, Solomon gives wisdom for how to live a life that actually matters.Through stories from the Dominican Republic, the Light Bearers Project, a powerful memorial service, and reflections on legacy, Pastor Brandon reminds us of three important truths: invest in the future, enjoy the season you are in, and keep God at the center of everything.If you want your life to leave a lasting impact, this message will encourage you to live with purpose, perspective, and eternity in mind.0:00 – YouTube Welcome from Pastor Brandon0:22 – Memorial Day Weekend Welcome0:44 – Opening Prayer1:11 – Pastor Brandon's Recent Trip Recap1:23 – Dominican Republic Trip + Solar Electricity Project1:46 – Country Music Awards + Travel Week2:10 – Brett Allen's Memorial2:54 – Ecclesiastes as Solomon's Final Speech3:21 – Dominican Republic Photos + Magdalena4:02 – Confronted by Poverty and Injustice4:34 – Why Missions Change Your Perspective4:56 – The Need for Electricity5:18 – Committing to Solar Power5:43 – The Three-Year Process6:10 – Out of Sight, Out of Mind6:54 – Returning to the Dominican Republic7:12 – Interviewing the Pastor7:41 – Why Electricity Matters8:07 – How Electricity Serves the Community8:32 – Praying and Fasting for Venture9:01 – Impact for the Next Two Decades9:11 – Home Visit Story9:47 – A Widow's Story in the Dominican Republic10:20 – How Electricity Helps Her Family10:38 – Compassion Sponsorship Story11:04 – Serving Hot Dogs to the Kids11:23 – Kids Saving Food for Their Parents12:08 – Food Storage and Electricity12:46 – The Weight of Her Story13:15 – Invitation to Give Toward the Project13:51 – Reflecting on Life and Legacy14:23 – Life Is Short14:58 – Solomon's Advice to the Next Generation15:27 – Ecclesiastes 9:1116:19 – Time and Chance Happen to Everyone17:11 – No One Knows Their Hour18:02 – Remembering Brett Allen18:51 – Life Can Be Gone Quickly19:25 – Country Music Awards Reflection20:22 – What Would Your Final Speech Say?20:53 – Three Things Solomon Tells Us to Do21:29 – Invest in the Future22:01 – Decisions Today Affect Tomorrow22:29 – Do Not Wait for Perfect Conditions22:58 – Sow Seeds for the Future23:49 – Brett Allen's Final Words24:56 – “Stay Here. Keep Working.”25:59 – The Value of Long-Term Friendship26:41 – Investing Early in Life27:36 – Investing in Apple Stock29:06 – Investing Your Life, Not Just Finances29:27 – Planting Venture Church29:59 – Airplane Conversation After the CMA Awards31:25 – The Impact of Venture in the Community32:10 – Why Investing in Kids Ministry Matters32:36 – Enjoy the Season You Are In33:07 – Remember God in Every Season33:49 – Advice for Your 20s34:45 – Enjoying the Empty Nest Season36:11 – Have Fun, But Remember God36:39 – Remember Your Creator37:37 – Life Has Meaning When God Is the Center38:09 – Solomon's Final Conclusion38:51 – Fear God and Keep His Commandments39:03 – Response Moment39:50 – Living with God at the Center40:42 – Commissioning Prayer41:30 – Leaving a Legacy42:17 – Closing Prayer43:51 – YouTube Outro

Pastor Zack Flipse preaches from Leviticus 11, “Food & Fasting.” —————————— More from Oostburg CRC Sermons: https://www.firstcrcoostburg.org/sermons Bible Study Resources: https://www.firstcrcoostburg.org/resources Original Music: https://open.spotify.com/album/4P7JbJlHzabPNW8GpdxKcB YouTube: https://www.youtube.com/channel/UCJSouYxM1rwWZ4cYAvTIqVA

I'm breaking down the exact nutrition principles I use to lose fat, get leaner, and stay consistent without going all-or-nothing. This episode covers calories, protein, meal timing, cravings, late-night snacking, and the small adjustments that compound into long-term results. Build the plan. Execute daily.CHAPTERS:00:00 Intro01:24 Goal of This Conversation08:18 The Truth About Calories In, Calories Out15:29 Start by Finding Maintenance19:06 Adjust Calories With Patience24:28 Avoid the All-or-Nothing Trap27:26 Meal Timing, Fasting, and What Matters Most36:54 Build Consistent Meals You Can Repeat40:22 Using Calorie Undulation With Intention46:28 How to Set Macros for a Cut47:05 Protein First for Fullness and Retention54:30 Fat Intake, Digestion, and Gut Health59:11 Use Carbs to Support Performance01:01:11 How to Stop Late-Night Snacking01:07:57 Go-To Meals That Make Dieting Easier01:10:53 How to Eat Out Without Losing Progress01:14:51 Small Changes That Drive Real ResultsORDER MY BOOK HERE: ⁠https://www.amazon.com/Go-One-More-Intentional-Life-Changing/dp/1637746210FOLLOW:Become a BPN member FOR FREE - Unlock 25% off FOR LIFE ⁠https://www.bareperformancenutrition.com/collections/performance-nutritionIG: ⁠instagram.com/nickbarefitness/⁠YT: ⁠youtube.com/@nickbarefitnessThis podcast is for informational purposes only and should not be considered legal [health or profession] advice. Bare Performance Nutrition (BPN) is not responsible for any losses, damages, or liabilities that may arise from the use of this podcast. This podcast is not intended to replace professional medical advice.This podcast may not be republished without the written consent of Bare Performance Nutrition (BPN)

In this month's spiritual formation conversation, we continue our series by reflecting on the practice of fasting and why it matters for our walk with Christ. Spiritual formation helps re-center our lives on Jesus when everything else competes for our attention. Fasting is more than just abstaining from food; it's intentionally setting something aside to create space to seek God. Looking at Jesus in the wilderness, we see how fasting prepares us to depend on God rather than comfort, control, or distraction. Alesia shares her experience fasting from social media and how it reduced anxiety, comparison, and noise while increasing presence and attentiveness to God. Brian shares his experience of fasting during a season of medical testing, and how it became a reminder of God's goodness and steadiness in uncertainty. Ultimately, fasting reveals what we rely on and invites us to re-center our lives on God. We encourage listeners to consider practicing fasting in some form this month as a way to step away from distractions and lean more fully into God's presence.  Episode Highlights:  Spiritual Discipline Fasting Living Less Distracted  Focusing on God  Foster Care Crisis   Find More on Hope Bridge: Visit Our Website  Follow us on Instagram Follow us on Facebook  

In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan, physically dominant and mentally sharp past 100. You don't need million-dollar lab work or intense weight training to reverse your biological age. Instead, these centenarians leverage five specific lifestyle protocols to naturally upgrade their biology. I explain the hard science behind how eating to 80% full shuts down the constant growth signaling that accelerates cellular aging. We'll also cover why the modern concept of retirement physically destroys your brain function within 2-3 years, and how specific social structures actually drop inflammatory chemicals in your body by up to 30%.Thank you to our sponsors!TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Intro00:47 – Okinawa's Origins01:28 – Hara Hachibu (80% Full)02:36 – Ikigai (Purpose)03:57 – Never Retire05:19 – Social Bonds (Moai)07:13 – Stress Resilience08:54 – The 5 HabitsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

EVEN MORE about this episode!What if the beauty industry has been teaching women to ignore the very signals their bodies are trying to send?In this episode, Julie Ryan and former international model Eva Hooft reveal the hidden links between trauma, chronic illness, gut health, and true healing.Eva shares the shocking reality behind the modeling industry—where perfection was demanded while her health quietly deteriorated. After years of severe gut issues, exhaustion, eating disorders, and feeling disconnected from herself, she realized her body wasn't failing her—it was desperately trying to communicate. What followed was a complete transformation that led her from the fashion world into holistic healing and somatic work.Together, Julie and Eva dive into the fascinating connections between trauma, parasites, inflammation, ancestral patterns, and the nervous system. They explore why many detox protocols can backfire, how emotional wounds may manifest physically, and why being told to “just live with it” can deeply impact healing. Packed with powerful insights, practical wellness tools, and inspiring stories of transformation, this episode offers hope for anyone who feels unheard, stuck, or exhausted from searching for answers.Guest Biography:Eva Hooft is a somatic & Detox Practitioner and works as a medical intuitive. Through her integrative approach—combining energetics, detoxification, mineral balancing, emotional release, somatics, astrology, energy healing, and more—Eva supports clients in addressing the root causes of physical and emotional imbalances.Episode Chapters:(0:00:00) - Introduction and Eva's Modeling Career(0:17:00) - Dark Reality of the Fashion Industry(0:24:00) - Discovering Root Causes of Illness(0:35:00) - Fasting, Detoxification, and Spiritual Connection(0:43:00) - Understanding Parasites and Heavy Metals(0:55:00) - Somatic Healing and Ancestral Trauma(1:06:00) - The Power of Words in Healing(1:15:00) - Practical Steps for Gentle Healing➡️ Subscribe to Ask Julie Ryan YouTube➡️ Julie's Intuitive Trainings✏️ Ask Julie a Question!

Prayer is essential for spiritual strength, yet many struggle with consistency. Through the examples of Paul and Silas praying with joy in prison, Anna's sacrificial devotion to prayer and fasting, and Epaphras wrestling in prayer for others, we learn three powerful approaches to prayer. Paul shows us how to maintain hope through prayer even in impossible circumstances. Anna demonstrates the discipline of consistent prayer and fasting over decades. Epaphras teaches us to intercede with strength for others, making common people uncommonly powerful through prayer.

Matthew 6:16-18Fasting should be SPIRITUALLY motivated, not SELFISHLY motivatedTypes of Biblical Fasts:-Normal-Partial-Absolute-Supernatural-Public-PrivateHow will fasting strengthen my faith?1. Fasting RENEWS your prayer life2.Fasting REDIRECTS you to God3. Fasting REMINDS you of God's power4. Fasting REFOCUSES your hunger

In this podcast, Pastor Victoria teaches out of Hebrews 5 about how to train your senses so that you can be a mature Christian, able to discern all things.Check out the full series on the book of Hebrews: https://youtube.com/playlist?list=PLGqHPNDG0wVfuvKbPz8yG_SbOOeXS7TBS&si=hRcPZR8AA9xEjV7ZLearn more about the Doctrine of Righteousness: https://youtube.com/playlist?list=PLGqHPNDG0wVez9IJ7G0VMgbo-gMW2KTU9&si=gMjppNXsar7v8xzNLearn more about Fasting and Prayer: https://youtube.com/playlist?list=PLGqHPNDG0wVfZeg5UzzNDnqxxIusutQuB&si=3krR4RJarv1xvQc8Learn more about overcoming the flesh: https://youtu.be/UnT0jOy7zH8?si=wBJyrXG0e1VzOsz8Check out our website to learn more about Arise Ministries: https://ariseministries.us Partner with us financially: https://ariseministries.us/give-1#532e4fd5-adcf-4c39-b82c-65615564f7ef CashApp @ariseGIVEVenmo @ariseGIVEFollow us on Instagram!

Light Therapy, 40Hz Gamma & Brainwave Entrainment: How BrainTap Resets Sleep, Clears Brain Fog, and Boosts Productivity by 26% Your brain is being starved of the one nutrient it needs most, and it is not a supplement, not a nootropic, not a fasting protocol. It is light, and a 40 hertz flicker delivered at the right frequency can break up amyloid plaque, reset your nervous system, and get you 26 percent more productive in a single session. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners Host Dave Asprey sits down with Dr. Patrick Porter, PhD, award-winning author, educator, entrepreneur, and founder of BrainTap, who has spent over 35 years at the forefront of neurotechnology helping millions of people achieve mental and emotional resilience through cutting-edge brain entrainment tools. Backed by 72 peer-reviewed studies and research conducted alongside Google, Microsoft, universities in Brazil, and veteran treatment programs, Dr. Porter is one of the most experienced and validated practitioners in applied neuroscience and brain optimization working today. Together, Dave and Dr. Porter break down exactly how flickering light and binaural sound delivered through the BrainTap headset feeds the brain through the electron transport chain, triggers nitric oxide release, boosts mitochondrial energy, and drives neuroplasticity through frequency following response. They cover how 40 hertz gamma light breaks up amyloid plaque and why that same frequency is linked to reversing dementia, how BrainTap reset the circadian rhythms of coal miners in under three weeks, how 490,000 students in Brazil raised their GPA using brain wave entrainment, and how AI now builds personalized 21-day brain training protocols from 3,000 available sessions. If you are serious about biohacking your brain, upgrading sleep optimization, and doing smarter not harder work on your mind, this episode delivers the science and the tools. You'll Learn: Why light is the most underrated nutrient for brain health and how BrainTap delivers it directly to every cell in your body How 40 hertz gamma frequency breaks up amyloid plaque, restores blood flow, and may reverse dementia and Alzheimer's progression Why binaural beats and isochronic tones trigger frequency following response and what that does to your focus, metabolism, and energy How three 10-minute BrainTap sessions per day produces 26 percent more work output according to studies with Google and Microsoft How BrainTap restored deep sleep and REM cycles in coal miners with destroyed circadian rhythms in under three weeks Why 90 percent of autistic children in one study began speaking after six weeks of pulsed light therapy targeting alpha wave production How AI inside BrainTap now generates personalized brain training protocols based on your specific stress, sleep, and performance goals Why the vagus nerve is the hidden target of BrainTap's ear lights and how triggering it drives parasympathetic recovery How SMR brain waves create the optimal state for focus and concentration and why elite athletes use this for both performance and academic results What the NeuroCheck system measures across nine parameters of the nervous system in five minutes and how it validates your biohacking results Thank you to our sponsors! - AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. - AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Patrick Porter, BrainTap, brainwave entrainment, light therapy, sound therapy, binaural beats, isochronic tones, 40 hertz gamma, gamma frequency, amyloid plaque, Alzheimer's prevention, dementia reversal, neuroplasticity, brain optimization, neurotechnology, frequency following response, SMR brain waves, alpha waves, delta waves, theta waves, vagus nerve, vagal stimulation, parasympathetic nervous system, nitric oxide, mitochondria, electron transport chain, sleep optimization, circadian rhythm reset, deep sleep, REM sleep, Oura Ring, HRV, cognitive performance, focus and concentration, productivity, nootropics, brain entrainment, photobiomodulation, red light therapy, near infrared light, biohacking, human performance, anti-aging, longevity, neurohacking, mental resilience, stress reduction, anxiety relief, autism therapy, pulsed light therapy, AI personalization, personalized wellness, meditation technology, Dave Asprey, Beyond Biohacking Conference, NeuroCheck, nervous system assessment, brain health, mental performance Resources: • Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:30 – Intro & Guest Welcome 01:45 – BrainTap: Light & the Brain 04:15 – 40Hz Gamma & Alzheimer's 05:55 – Sound & Binaural Beats 07:26 – Usage Protocol & Results 08:37 – Sleep & Circadian Reset 09:29 – AI-Personalized Sessions 10:47 – Conference Preview 12:19 – Vagus Nerve & Ear Lights 13:33 – Closing & Offer See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show. Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up. You'll Learn: Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one Thank you to our sponsors! - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity Resources: • Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:37 – Intro 03:57 – Pomegranates 10:03 – Discovering Urolithin A & Mitophagy 20:50 – Science vs. Pomegranate Supplements 25:24 – Topical Skincare Science 26:09 – L'Oreal Partnership & Skin Results 33:38 – 15 Clinical Studies & XPRIZE 43:50 – Nature Aging Immune Study 49:22 – Dosing & Daily Routine 51:29 – Future of Mitochondrial Health See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Andrea welcomes back metabolism scientist and women's health educator Liz for part two of this conversation on fasting, hormones, metabolism, perimenopause, and why women's health is far more nuanced than the internet makes it seem. They break down the truth about intermittent fasting, stress, muscle, nutrition, aging, and how to support your body without falling into fear based wellness advice. If you've been struggling with fatigue, weight changes, hormone shifts, or feeling overwhelmed by conflicting fitness advice, this episode will help you focus on what actually matters.Follow Dr. Alyssa Olenick @doclyssfitness Make Fit Simple is sponsored by KION Go to Getkion.com/simple for 20% off. Join my newsletter!  https://www.deliciouslyfitnhealthy.com/emlsFollow the Make Fit Simple Podcast@MakeFitSimplePodcastHave a suggestion for a topic click HEREHave a suggestion for a guest click HERENEW! Leave a question for Andrea HERE on SpeakPipe!Follow Andrea on Instagram@deliciouslyfitnhealthy@dfh.training.picsTraining & Coachinghttps://www.deliciouslyfitnhealthy.com/linksVisit Andrea's Websitewww.deliciouslyfitnhealthy.comProduced by Light On Creative Productions 

371: Dr. Molly Maloof joins me to discuss cortisol, burnout, fasting, women's metabolism, and why so many women may actually be overdoing wellness in the name of health. We break down how chronic stress, over-exercising, under-eating, and high cortisol can impact weight gain, hormones, metabolism, and overall well-being, along with who should and shouldn't fast, low-carb eating, intermittent fasting for gut health, boundaries, emotional health, human connection, and why learning to slow down may actually improve your health more than constantly pushing harder. Topics Discussed: → Cortisol, stress, & burnout → Fasting for women → Women's metabolism & biohacking → Over-exercising & under-eating → Weight gain & high cortisol → Intermittent fasting for gut health → Low-carb eating & metabolic flexibility → Boundaries, emotional health, & human connection → Burnout recovery & nervous system regulation → Exercise, muscle health, & longevity As always, if you have any questions for the show please email us at digestthispod@gmail.com. And if you like this show, please share it, rate it, review it and subscribe to it on your favorite podcast app.  Sponsored By:  → Timeline | Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $99, with the exact same science and formula. And my listeners can still get 20% off when you go to https://timeline.com/DIGEST  → Kasandrinos | Go to https://www.kasandrinos.com/digest and use code DIGEST for 25% off Timestamps:  → 00:00:00 - Introduction → 00:04:01 - Why Women Should Biohack Differently Than Men → 00:06:29 - Cortisol, Overtraining & Burnout → 00:09:30 - Fasting for Women: Who Should & Shouldn't Do It → 00:11:30 - High Cortisol, Stress & Fight-or-Flight Mode → 00:14:48 - Adaptogens, Recovery & Nervous System Support → 00:17:30 - Why Less Exercise Can Sometimes Help Weight Loss → 00:21:30 - Undereating, Metabolism & Thyroid Health → 00:26:15 - How to Start Intermittent Fasting Safely → 00:31:00 - Fasting for IBS, Gut Health & Metabolic Flexibility → 00:33:00 - Negative Thoughts, Stress & Emotional Health → 00:38:40 - Why Human Connection & Touch Matter for Health → 00:42:15 - Burnout, Recovery & Learning to Slow Down → 00:46:30 - Stress, Trauma & Obesity → 00:49:30 - Sugar Addiction, Food Cravings & Emotional Eating → 00:51:30 - Dr. Molly Maloof's Typical Day of Eating → 00:57:30 - Autoimmunity, Inflammation & Personalized NutritionFurther Listening: → “Intermittent Fasting” How To Do It, Different Types, Misconceptions, + Benefits | BOK Check Out Dr. Molly Maloof:  → Instagram - Dr. Molly Maloof → Sign up for Molly's Newsletter  Check Out Bethany: → Bethany's Instagram: @lilsipper → YouTube → Bethany's Website → Discounts & My Favorite Products → My Digestive Support Protein Powder → Gut Reset Book  → Get my Newsletters (Friday Finds) Produced by Drake Peterson Learn more about your ad choices. Visit megaphone.fm/adchoices

We're looking at some recent headlines — discussing why rising carbon dioxide is diluting nutrients in crops, whether overnight fasting and early breakfasts can actually help you control appetite and manage weight, and why cycle‑based diets aren't worth the hype.

What is God's real purpose for fasting? Find out with Nathan Jones and Vic Batista on the podcast, The Truth Will Set You Free!

Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity. Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. You'll Learn: Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle How oxytocin drives wound healing, immune function, and the placebo response Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love The top peptides for mitochondrial repair, brain optimization, and telomere biology Why Dave and Dr. Maloof believe we have already reached longevity escape velocity How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism How to build the adaptive capacity and bioenergetic reserves to bounce back from anything Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18 - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Molly Maloof, Adamo Bioscience, Stanford University, personalized medicine, functional medicine, healthspan, longevity, biohacking, human performance, anti-aging, regenerative medicine, longevity escape velocity, cell danger response, mitochondria, mitochondrial health, oxytocin, vasopressin, dopamine, serotonin, neurobiology of love, attachment theory, pair bonding, sex drive, hormone replacement therapy, testosterone, estrogen, menopause, andropause, libido, female sexual dysfunction, relationship biology, social health, isolation, community, co-regulation, trauma healing, psychedelics, MDMA, psilocybin, ibogaine, ayahuasca, hormetic stress, social hormesis, neurofeedback, 40 Years of Zen, breathwork, nervous system regulation, HPA axis, cortisol, mast cell activation, histamine, long COVID, mold exposure, phospholipid therapy, glutathione, vitamin C, BPC-157, TB500, SS31, epothilone, SELANK, SEMAX, BDNF, telomere biology, telomerase, peptides, GLP-1, placebo response, wound healing, metabolism, continuous glucose monitoring, gut health, AI, precision medicine, supplements, brain optimization, neuroplasticity Resources: • Grab Molly's Book The Spark Factor: https://www.amazon.com/Spark-Factor-Supercharging-Optimizing-Feeling/dp/0063207206 • Learn More About Dr. Molly's Work: https://drmolly.co/ • Visit Your Healthspan Journey: https://yourhealthspanjourney.mystrikingly.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:28 – Intro 01:39 – COVID Isolation & Its Effects 03:11 – Science of Love & Hormones 04:24 – Psychedelics & Love Chemistry 09:22 – Cell Danger Response 11:07 – AI, Tech & Human Connection 13:20 – Social Connection as Medicine 20:50 – Placebo, Care & Psychedelics 24:49 – Altered States & Healing Modalities 30:09 – Peptides & Longevity Drugs 35:44 – Mast Cell & Personal Health Challenges 43:46 – Regenerative Medicine & The Future 46:17 – Longevity Escape Velocity 50:05 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Fasting is not a switch — it's a sequence. Episode #258

Why Isn't Everyone Talking About Mitochondria? with Jennifer Scheinman Most people learned the word in 10th-grade biology and never thought about it again. That, argues registered dietitian and longevity expert Jennifer Scheinman, is exactly the problem. In this episode of Why Isn't Everyone Doing This?, Emily Fletcher sits down with Jennifer, a nutritionist with over 25 years of experience and a longevity expert at Timeline, the company behind the clinically studied Urolithin A supplement MitoPure, for a conversation that reframes everything from fatigue to aging to consciousness through the lens of your cells. Jennifer explains how the mitochondria work, why their decline accelerates in your 40s and 60s, and what you can actually do to slow that process. They cover the 12 biological hallmarks of aging, the cellular recycling system (mitophagy) that breaks down over time, why so many people can't produce Urolithin A on their own, and how to evaluate supplements in an industry the FDA doesn't fully regulate. They also connect it all to meditation, to stress, to perimenopause, and to the Greek myth of Persephone and the pomegranate. And at the very end: a fact about mitochondrial DNA that changes the way you think about your mother, your grandmother, and the feminine line you carry. In this episode, they explore: – What mitochondria are, what they do, and why they're more like a CEO than a powerhouse – The cellular recycling process (mitophagy) and why it slows with age – Zombie cells, inflammaging, and the 12 hallmarks of biological aging – Why aging isn't linear — and what the research says about the 40s and 60s – How meditation reduces the inflammation driving cellular decline – Urolithin A: what it is, how your gut should be making it, and why most people's isn't – How to read supplement labels and avoid "fairy dusting" and borrowed science – Timeline's clinical research: what the trials showed and how long results take – The topical MitoPure skincare line and UV-related skin aging – Why mitochondrial DNA is inherited exclusively through the maternal line – Persephone, pomegranates, 108 seeds, and the convergence of myth and molecule Key Moments: 00:00 — The question that opens the episode 03:00 — Mitochondria 101: what they really are 08:15 — Every cell except red blood cells runs on mitochondrial energy 10:00 — Mitophagy: your body's cellular cleanup crew 13:00 — Why aging accelerates in the 40s and again in the 60s 16:00 — Zombie cells and the inflammaging hallmark 19:00 — Meditation's effect on cellular inflammation — the Ziva link 25:00 — Fasting and perimenopause: what the science says for women 29:00 — How to evaluate supplements when labels aren't regulated 35:00 — Urolithin A: gut-made, often missing, and why it matters 40:00 — Why food alone won't get you there (6 cups of pomegranate juice a day) 44:00 — The clinical trials: muscle endurance at 2 months, strength at 4 months 53:00 — Urolithin A + exercise: a likely additive effect 58:00 — How Dr. Gabrielle Lyon first put this on Emily's radar 01:01:00 — The skincare line: bringing MitoPure topically 01:03:00 — Mitochondrial DNA and the matrilineal inheritance 01:05:00 — Persephone, pomegranates, and the place where science meets spirit About Jennifer Scheinman Jennifer Scheinman is a registered dietitian and nutritionist with over 25 years of experience. She is a longevity and nutrition expert at Timeline, the company behind MitoPure — a clinically researched Urolithin A supplement backed by over $50 million in human studies. Her mission is making the science of longevity accessible, practical, and connected to how you actually feel. Follow Jennifer: @jenscheinmanrdLearn more: https://timelinenutrition.com This episode is sponsored by Timeline. Support your mitochondrial health and get 20% off Mitopure at http://timeline.com/ziva. ✨ The Portal is open. If this conversation stirred something in you — around energy, consciousness, and what becomes possible when your body is resourced — you may be ready for what's next. The Portal is Ziva's newest immersive experience, with a VIP weekend for those who want to go further. If you feel the pull, follow it.

Join my Clubhouse App - https://ericrobertsfitness.com/clubhouse-page.html On today's episode I answer a ton of rapid-fire questions from a recent TikTok live — everything from stress eating and intermittent fasting to menopause weight gain, how many sets you actually need, and why losing a pound a week is better progress than you think. I break down what actually matters versus what social media has convinced you matters, and I don't sugarcoat any of it. Work With Me 1:1 Coaching - https://ericrobertsfitness.com/erf-1on1.html Free Calorie Calculator https://ericrobertsfitness.com/free-calorie-calculator/ 20% Off Legion Athletic Supplements Code “ERIC” HERE https://legionathletics.rfrl.co/qj2dy Youtube Channel https://www.youtube.com/@ericrobertsfitness Video Podcast: https://www.youtube.com/@EricRobertsFitnessPodcast

Most guys over 40 rely on coffee just to survive the day, completely unaware that they are pushing their brains into a frantic, high-stress state that actually destroys deep focus and accelerates cognitive decline. In this video, I reveal the science behind why caffeine is failing you and introduce you to a 4,000-year-old amino acid used by monks to achieve effortless, sustained attention. I'll walk you through the optimal 2:1 biohacking stack that flips your coffee from a nervous, jittery habit into a highly controlled focus weapon. You'll learn exactly how to dose it, when to take it, and how to stop the hidden lifestyle habits that are secretly sabotaging your nervous system, so you can reclaim the mental edge you had in your twenties and stay competitive.Thank you to our sponsors!-HeartMath | Go to https://www.heartmath.com/dave to save 15% off-The One Device | Use code DAVE for $10 off at theonedevice.com/dave-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Intro00:21 – Background & Credentials01:28 – How Caffeine Works03:01 – Alpha vs Beta Brainwaves04:06 – The Focus Amino Acid04:55 – What Is L-Theanine05:35 – Quality & Common Mistakes06:51 – Building the Stack08:37 – Lifestyle Foundations10:36 – Rules & GuidelinesConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Every diet you've ever tried has failed you for one reason: it never told you when to eat. Your body runs on two energy systems. One burns sugar. The other burns fat. Most people never spend a single day in the second one. Around eight to ten hours without food, the switch flips. Ketones flood your brain. Hunger quiets. Mental clarity hits. Healing turns on. This is what fasting expert Dr. Mindy Pelz has been teaching for over 25 years, and what her book Fast Like a Girl made impossible to ignore. For women, timing is everything. Day 1 to 10, fast longer and lift heavier. Day 11 to 15, testosterone surges and libido climbs. Day 16 to 19 is for deeper fasts. After day 20, progesterone needs you to back off and rest. Fast like a man during the back half of your cycle and you'll tank the very hormones keeping you calm and regular. Underneath all of it sits the hormonal hierarchy. Oxytocin at the top. Cortisol below it. Then insulin. Then sex hormones. When you feel safe and connected, the whole stack works. When you don't, nothing else matters. Connection isn't optional for women. It's biology. Dr. Mindy's books: Age Like a Girl How Menopause Rewires Your Brain for Mental Clarity, Increased Confidence, and Renewed Energy Eat Like a Girl: 100+ Delicious Recipes to Balance Hormones, Boost Energy, and Burn Fat Fast Like a Girl: A Woman's Guide to Using the Healing Power of Fasting to Burn Fat, Boost Energy, and Balance Hormones The Menopause Reset: Get Rid of Your Symptoms and Feel Like Your Younger Self Again The Reset Factor Kitchen: 101 Tasty Recipes to Eat Your Way to Wellness,Burn Belly Fat, and Maximize Your Energy The Reset Factor: 45 Days to TransformingYour Health by Repairing Your Gut In this episode you will: Learn the fasting cycle for women, Dr. Mindy's day-by-day framework that syncs your fasting window, workout intensity, and food choices to your menstrual cycle Uncover why your menstrual cycle is a monthly detox rather than a burden, and what an irregular or absent cycle is actually telling you about your body Discover why timing your eating matters more than what you eat, and how the ketogenic energy system unlocks fat burning, mental clarity, and steady energy Understand the hormonal hierarchy, how oxytocin, cortisol, insulin, and sex hormones stack on each other, and why female community and connection function as biological medicine Find out what long-term birth control does to the gut microbiome and the brain-ovary connection, and why so many women struggle with hormonal imbalances after coming off the pill For more information go to https://lewishowes.com/1928 For more Greatness text PODCAST to +1 (614) 350-3960 Follow The Daily Motivation for essential highlights from The School of Greatness More SOG episodes we think you'll love: Glucose Goddess Dr. Mary Claire Haver Dr. Mark Hyman TOPICS Dr. Mindy Pelz, intermittent fasting, ketogenic energy system, fasting cycle for women, hormonal hierarchy, menstrual cycle nutrition, cortisol and stress, birth control and microbiome, oxytocin and women's health, Fast Like a Girl Get more from Lewis! Get my New York Times Bestselling book, Make Money Easy!Get The Greatness Mindset audiobook on SpotifyText Lewis AIYouTubeInstagramWebsiteTiktokFacebookX Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper A randomized, double-blind crossover trial kept 29 healthy adults awake for 21 hours straight ... half the time on a single moderate dose of creatine (~14g), half the time on placebo ... and found the creatine group held on to up to 12% more cognitive performance across logic, reaction time, and language processing. Host Dave Asprey breaks down why sleep deprivation is just another form of brain energy stress, how creatine's phosphate-buffering mechanism stabilizes ATP in the prefrontal cortex under pressure, and why this changes how he thinks about red-eye flights and all-nighters. Vegetarians and women showed the largest effects ... your baseline diet sets your ceiling. Sources: https://pubmed.ncbi.nlm.nih.gov/42075005/ https://www.nutraingredients.com/Article/2026/04/21/single-dose-creatine-may-support-cognition-in-sleep-deprivation-study/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/ https://medicalxpress.com/news/2024-04-creatine-cognitive-deprivation.html Your Gum Is Dosing You With Thousands of Microplastics A pilot study tested 10 commercial gums ... five synthetic, five marketed as natural or plastic-free ... and found every single one shed hundreds to roughly 3,000 microplastic fragments per stick into saliva, with no meaningful difference between synthetic and "natural" varieties. Host Dave Asprey connects this to total toxic load management, explains why "natural" label claims mean nothing without polymer-free verification, and makes the case that even innocent daily habits contribute to the cumulative plastic burden most people aren't tracking. The takeaway isn't panic ... it's precision. Sources: https://www.acs.org/pressroom/presspacs/2025/march/chewing-gum-can-shed-microplastics-into-saliva-pilot-study-finds.html https://www.sciencedirect.com/science/article/pii/S2666911025000243 https://samueli.ucla.edu/bursting-your-bubble-chewing-gum-releases-microplastics-into-your-saliva-ucla-research-shows/ https://www.food-safety.com/articles/10285-study-shows-chewing-gum-releases-thousands-of-microplastics-whether-gum-is-synthetic-or-natural Irregular Bedtimes in Your 40s May Double Heart Attack Risk Finnish researchers followed 3,231 people from age 46 using objective accelerometer data and tracked cardiovascular outcomes for a decade ... finding that people with highly irregular bedtimes, especially combined with short sleep, had roughly double the risk of major cardiovascular events compared to those with consistent sleep timing. Host Dave Asprey explains why your vascular biology runs on a precise circadian schedule, why ambitious, otherwise-healthy people are most at risk of ignoring this lever, and why a 90-minute bedtime window ... protected even on weekends ... may be one of the cheapest cardiovascular interventions available. It'snot just how much you sleep. It's when. Sources: https://www.sciencedaily.com/releases/2026/05/260504154026.htm https://hsph.harvard.edu/topic/aging/ Scientists Decode the Plant Molecule That Kills Cancer Cells in the Lab UBC researchers published a chromosome-level genome map of Mitragyna parvifolia ... a kratom relative ... and used it to decode the full biosynthetic pathway for mitraphylline, a rare alkaloid that has shown real anti-tumor activity in cell and animal models but has never been producible at clinical scale. Host Dave Asprey explains why this is the same early chapter that vincristine and paclitaxel were in before becoming mainstream chemotherapy, draws a hard line between this pipeline story and influencer narratives about kratom as a cancer treatment, and breaks down what it actually means when researchers crack a plant's genetic recipe for a bioactive compound. Nature has been solving cancer for millions of years... we're finally learning to read it. Sources: https://academic.oup.com/plcell/article/37/9/koaf207/8237526 https://www.sciencedaily.com/releases/2026/05/260512213836.htm https://news.ok.ubc.ca/2025/10/14/researchers-reveal-how-plants-make-anti-tumour-drugs/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12217235/ Scientists Built an On/Off Switch for Sperm Production — No Hormones Cornell researchers used a small-molecule inhibitor called JQ1 to pharmacologically shut down sperm production in male mice for the duration of treatment, then stopped the drug and watched full fertility restore... with healthy offspring and no detectable genomic damage. Host Dave Asprey breaks down the BRDT mechanism that makes this work without touching testosterone or hormones, explains why this is a proof-of-concept rather than a near-market drug, and outlines the questions that need answering before this moves to humans: long-term testicular health, epigenetic marks in recovered sperm, and mood and testosterone interaction over time. The era of precision male reproductive biology is just beginning. Sources: https://pubmed.ncbi.nlm.nih.gov/41945432/ https://www.sciencedaily.com/releases/2026/04/260407193844.htm https://www.news-medical.net/news/20260407/Study-advances-safe-reversible-male-contraceptive-without-hormones.aspx https://www.independent.co.uk/news/science/breakthrough-male-birth-control-sperm-b2972841.html This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cognitive performance, toxic load management, circadian biology, plant-derived drug discovery, and the future of male reproductive medicine. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: creatine sleep deprivation cognition, brain energy ATP creatine, microplastics chewing gum, natural gum microplastics, toxic load biohacking, irregular bedtime heart attack risk, circadian rhythm cardiovascular, sleep timing heart health, mitraphylline cancer compound, kratom plant alkaloid drug discovery, oncolytic plant molecule, male birth control non-hormonal, sperm production reversible, BRDT JQ1 contraception, biohacking news 2026, longevity research, performance optimization, healthspanextension Thank you to our sponsors! - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:36 – Fluoride Correction 01:14 – Story 1: Creatine & Sleep Deprivation 03:21 – Story 2: Microplastics in Gum 04:53 – Story 3: Irregular Bedtimes & Heart Risk 06:31 – Story 4: Kratom Plant & Cancer Research 08:18 – Story 5: Male Contraception On/Off Switch 10:02 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you're over 50 and still doing cardio to stay healthy, you're wasting your time and may actually be making things worse. This episode breaks down the exact movements, supplements, and anti-aging strategies that build real strength, protect your bones, and extend your longevity without spending hours in the gym. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Will Harlow, a master's-level physiotherapist and founder of HT Physio, whose YouTube channel has amassed over 1.5 million subscribers by teaching people over 50 how to stay mobile, active, and independent without painkillers or surgery. Will graduated with a first-class degree from Brunel University, trained in both the NHS and professional sport, and has spent his career proving that what most doctors call "just aging" is actually optional. Together, Dave and Will dismantle the myths keeping older adults weak, injured, and overtrained. They get into why resistance training beats cardio for human performance and metabolism at every age, how anabolic resistance changes your protein needs after 50, which three compound movements deliver the biggest functional gains, and why your grip strength may be the most underrated biomarker you're ignoring. Dave also shares how he used biohacking, targeted supplements, and functional medicine principles to grow bones so dense his surgeon couldn't cut through them. They also dig into vestibular training, hydration, magnesium, Vitamin DAKE, and how tools like AI are now helping people identify movement problems before they become joint replacements. This is essential listening for anyone serious about longevity, anti-aging, biohacking, sleep optimization, supplements, smarter not harder training, human performance, and building a body that performs decades past its expiration date. You'll Learn: Why chronic cardio decreases bone density and muscle mass in people over 50 The 3-2-1 resistance training method that delivers 80% of results in 40 minutes a week How anabolic resistance changes protein requirements as you age and what to do about it The three compound movements every person over 50 should master first Why grip strength predicts overall health and how to train it How vestibular disorders silently destroy balance and confidence, and how to reverse them The supplement stack (Vitamin DAKE, magnesium glycinate, digestive enzymes) that supports bone, muscle, and metabolism Why 7,000 steps beats 10,000, and where that number actually came from How Dave used biohacking and functional medicine to grow bones that broke a surgeon's saw Why AI tools can now spot gait problems that lead to hip replacements years later Thank you to our sponsors! - Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Quantum Upgrade | Go to QuantumUpgrade.io/DAVE to claim your 15-day free trial - fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Will Harlow, HT Physio, Independence for Life, physiotherapy, physical therapy, over 50 fitness, resistance training, strength training, muscle mass, bone density, osteoporosis, goblet squat, Romanian deadlift, farmer's carry, compound movements, progressive overload, 3-2-1 method, exercise snacks, balance training, vestibular health, vestibular disorders, fall prevention, hip fracture, anabolic resistance, protein intake, muscle protein synthesis, grip strength, zone 2 cardio, overtraining, sarcopenia, frailty, mobility, functional movement, gait analysis, fascia, inflammaging, NLRP3, EGCG, green tea extract, luteolin, shockwave therapy, digestive enzymes, betaine HCL, stomach acid, magnesium glycinate, Vitamin K2, Vitamin DAKE, zinc, calcium, electrolytes, cortisol, testosterone, anti-aging, longevity, biohacking, supplements, human performance, metabolism, AI, Dave Asprey, 7000 steps, 10000 steps, pedometer, body weight training, resistance bands, home workout, senior fitness, healthy aging, biological age, heart rate variability, VO2 max, morning stiffness, hip pain, knee pain, back pain, fascia hydration, infant reflexes, vestibular training, eye tracking, sit to stand, bone density surgery, dense bones, UK healthcare, NHS, healthcare system Resources: • Preorder Will's Upcoming Book Independence for Life (5/26) at: https://www.penguinrandomhouse.com/books/804636/independence-for-life-by-will-harlow/ • Learn More About Will's Work: https://willharlow.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:36 – Intro 02:59 – Why Resistance Training Matters 03:38 – US vs. UK Health Culture 06:15 – Getting Started with Resistance Training 07:12 – Top 3 Movements Over 50 10:30 – Hip Mobility & Inflammation 12:19 – Hydration, Joints & Electrolytes 14:11 – Balance, Falls & Exercise Snacks 15:21 – Biological Age & Longevity 16:41 – Biohacking vs. Optimization 20:08 – Overtraining & the 3-2-1 Method 29:42 – Protein & Anabolic Resistance 33:57 – Energy, Fat & Cortisol 37:49 – Vestibular Health & Balance 50:07 – Gait & Movement Rehab 56:56 – Steps, VO2 Max & Wearables 57:25 – Book Promo 01:02:14 – 7,000 Steps 01:04:22 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.