Podcasts about IND

⏱️ Capítulos do vídeo00:00 O plano econômico de Lula01:13 Contas públicas e dívida do Brasil03:38 Juros e inflação05:21 Planejamento de investimentos RC Wealth06:18 Impostos e reforma tributária08:25 Indústria e acesso ao crédito10:38 Infraestrutura e concessões12:10 Petrobras e preços dos combustíveis14:22 Conclusão

Este episódio abre a segunda temporada do ciclo de leituras do grupo CEPCOM (Crítica da Economia Política da Comunicação), da Universidade Federal de Alagoas (Ufal), voltado à formação da base da Economia Política da Comunicação com mestrandas e mestrandos.Aqui, apresenta e busca aplicar às pesquisas do primeiro terço do capítulo "As contradições da informação" (p. 25-41) do livro "Indústria Cultural: Informação e Capitalismo" (Bolaño, 2020).O texto foi apresentado por Marina Ferreira e Henrique Lemos (mestranda mestrando em Comunicação da Ufal), com comentários de Anderson Santos (professor dos mestrados em Comunicação da Uel e da Ufal), Vitória Rocha (mestranda em Comunicação da Ufal), Júlio Arantes (professor do mestrado em Comunicação da Ufal) e Lucas Gomes (estudante de Jornalismo da Ufal).Referência principalBOLAÑO, C. As contradições da Informação. In: BOLAÑO, C. Indústria Cultural: Informação e Capitalismo. São Paulo: Hucitec, 2000.Referências citadasBOLAÑO, C. O campo aberto. São Cristóvão: Edufs, 2016.Episódios do Jogando Dados: #01 Desinformação, #37 Indústria Cultural, Informação e Capitalismo

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Lloyd B. Klickstein is a physician-scientist who has spent more than 20 years at the intersection of drug discovery, healthy aging, and preventive medicine. Drawing on his experience in academic medicine, translational research, and biotechnology, Lloyd walks through the full arc of modern drug development. He explains how scientists identify an unmet medical need and decide which diseases and therapeutic targets are worth pursuing. From there, he takes us through the process of engineering a drug, testing it in animals, and navigating clinical trials and regulatory approval. Using bimagrumab as a case study, Lloyd explains the rationale for targeting myostatin and activin signaling to increase muscle mass and strength and describes how the antibody was engineered and screened. He then walks through what was learned from early clinical trials. Unexpected effects on fat mass and type 2 diabetes helped reshape bimagrumab's development as a potential treatment for obesity, including its use in combination with semaglutide. Along the way, Peter and Lloyd explore the differences among drug modalities, including biologics and small-molecule therapeutics. They discuss the roles of patents and capital allocation in drug development, along with the requirements for IND submission and GMP manufacturing. They also examine why developing a new drug takes so long and costs so much, and why identifying failures early is critical. At the end of the episode, the conversation turns to mTOR inhibition and geroprotection, as well as Lloyd's current work on a novel pharmacologic approach to cancer prevention. This episode provides a rare behind-the-scenes look at how new medicines are actually created and the scientific, regulatory, and economic decisions that determine which ideas ultimately make it to patients. We discuss: Lloyd's path from academic medicine to translational drug development [3:15]; Drug modalities, patents, and the economics of innovation [11:30]; Choosing sarcopenia as a target for drug development, and confronting the problem of measuring falls [23:00]; The rationale for bimagrumab: improving muscle mass and strength by targeting myostatin and activin signaling (and why follistatin failed) [36:45]; Engineering and screening the bimagrumab antibody, and the cost of developing a new drug [43:45]; From candidate antibodies to animal proof of concept (impressive muscle hypertrophy) [54:15]; Toxicology, capital allocation, and the path to an IND [1:02:45]; IND requirements, GMP manufacturing, and gray market peptides [1:14:45]; First in-human study design, patient selection, and protection of healthy volunteers [1:22:00]; Phase 1 dosing, pharmacodynamics, and global trial strategy [1:33:45]; Phase 2 lessons on muscle mass, function, and nutrition [1:43:30]; Bimagrumab's effects on fat mass and type 2 diabetes [1:50:45]; The BELIEVE trial of bimagrumab plus semaglutide [1:59:30]; Selective mTORC1 inhibition and the challenge of testing geroprotection [2:11:45]; A new pharmacologic approach to cancer prevention [2:15:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

A People's Climate is back for Season 2. Host Shilpi Chhotray takes you inside the fight for climate and environmental justice with organizers, legal experts, filmmakers, and movement leaders challenging the corporate and political forces blocking real change — from Big Oil and militarism to over-policing and the Supreme Court. This is essential listening for anyone serious about building a mass climate movement.New episodes every Saturday starting Oct 3, 2026.Guests this season include:LaTricea Adams - Founder and CEO of Young, Gifted & GreenBrea Baker - Writer, Activist and Author of ROOTED: The American Legacy of Land Theft & The Modern Movement for Black Land OwnershipDr. Hatem Bazian - Decolonial scholar, professor at UC Berkeley, author, and activistJohn Beard Jr. - Founder and CEO of the Port Arthur Community Action NetworkNalleli Cobo - Environmental Activist and Co-Founder of South Central Youth Leadership CoalitionKamau Franklin - Founder of Community Movement BuildersU.S. Representative Maxwell Alejandro Frost - Florida's 10th Congressional DistrictAbby Martin - Investigative journalist, Director of Earth's Greatest Enemy, and founder of The Empire FilesElie Mystal - Justice Correspondent for The NationSean Sherman - Chef and Founder of Indígena by Owamni and North American Traditional Indigenous Food SystemsAnd more to be announced.CreditsPresented by Counterstream Media and The NationPowered by Wildseeds FundHost: Shilpi ChhotrayExecutive Producer: Mindy Ramaker Engineer: Dennis MaxwellProject Manager: Asia SimmsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Will Anderson Jr. Called a TEAM MEETING for the Texans.. It's Been 2 Weeks; + With Nico Officiallly OUT for Texans.. What are the EXPECTATIONS Sun. @ IND! + "The NICK CALEY Game" Texans @ Colts Sunday in Week 3 Matchup

FOOTBALL FRIDAY #3 with The Drive! But.. LUCAS SPENCE, have a NIGHT! Also, It's Looking Like NO NICO for Stroud & Co. for 2nd Straight Week Sun. @ IND.. AND, The Drive's 1st hour dives into the October chasing Astros! Astros Playoff Hopes CHECK IN! 3 Games Remain for the 2026 'Stros

PREDICTION TIME! Clint, Ron The Show, & T-Mil Give their Texans/Colts Score for the Week 3 action in Indy! Who YOU got, Houston?! + The Milner Heater Continues with 3x3 Last Night on TNF! T-MIL'S BEST BETS! + Time for Diesel AKA Hunter Brown to Show that ACE Stuff! 'Stros Chasing Oct + With Nico Officiallly OUT for Texans.. What are the EXPECTATIONS Sun. @ IND; + According to our former NFL QB Stoerner, "The NICK CALEY Game" Texans @ Colts Sunday.. + Our Guy T-Mil Does NOT Seem Confident About his Aggies @ LSU! Sat. Slate! KEY MATCHUPS to Watch Sunday Texans @ Colts

Ranking Every Week 3 Running Back as a Sit or Start: https://youtu.be/vzeyeiWqd8QSign up for the BDGE Fantasy membership here: https://bdge.co/membership0:00 - it's rude to skip introductions0:23 - GB vs ATL2:58 - LAC vs BUF5:08 - CAR vs CLE8:20 - NYJ vs DET10:38 - IND vs HOU13:34 - JAC vs NE15:41 - KC vs MIA16:34 - NYG vs TEN18:26 - CIN vs PIT20:45 - SEA vs WAS22:00 - ARI vs SF24:03 - MIN vs TB26:34 - DAL vs BAL28:04 - LV vs NO29:18 - DEN vs LAR32:02 - PHI vs CHIsubscribe to the bdge dynasty channel: https://ytube.io/3pZklisten to the bdge dynasty podcast: https://bityl.co/NzJ1bdge nfl trivia youtube channel: https://ytube.io/3jmJjoin the BDGE discord: https://discord.gg/77BxrqCF6Fsubscribe to the BDGE podcast | https://linktr.ee/bdgefollow me on the socials | https://linktr.ee/nickercolanoContact▪️ business inquiries | business@bdge.co▪️ customer support/help | help@bdge.co▪️ fantasy questions can go in our discord | https://discord.gg/AvpY3QJTAythis video is about (Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

As terras raras estão no centro de disputas geopolíticas por causa de seu uso em áreas como economia digital, transição energética e indústria bélica. No Brasil, país que detém a segunda maior reserva global desses recursos, a exploração dos minerais críticos virou assunto eleitoral, sendo citada no plano de governo dos seis principais candidatos à Presidência. O sétimo Durma com Essa da temporada especial sobre as Eleições 2026 explica o que são as terras raras e minerais críticos, e ouve pesquisadoras da área para entender o que o Brasil pode fazer para fugir ao modelo extrativista reproduzido desde 1500. O episódio conta com a participação de Renata Albuquerque Ribeiro, pós-doutoranda do Grupo de Indústria e Competitividade, do IE-UFRJ (Instituto de Economia da Universidade Federal do Rio de Janeiro); e de Elaine Santos, socióloga e pesquisadora do Laboratório Nacional de Energia e Geologia, em Portugal. Apresentação: Marcelo Roubicek e Mariana Vick Roteiro: Marcelo Roubicek Edição de texto: Antonio Mammi Pesquisa: Victoria Rengel Edição de áudio: Brunno Bimbati Produção de arte: Yasmin Menezes Ilustração: Lua Lopes Distribuição: Paulo Cantalice e Pedro Bardini Learn more about your ad choices. Visit megaphone.fm/adchoices

Sign up for the BDGE Fantasy membership here: https://bdge.co/membership0:00 - it's rude to skip introductions0:57 - GB vs ATL3:06 - LAC vs BUF4:16 - CAR vs CLE6:24 - DET vs NYJ7:59 - IND vs HOU9:42 - JAC vs NE14:03 - MIA vs KC14:57 - NYG vs TEN17:37 - SEA vs WAS20:03 - CIN vs PIT24:01 - MIN vs TB25:58 - BAL vs DAL26:29 - LV vs NO30:02 - LAR vs DEN32:34 - PHI vs CHIsubscribe to the bdge dynasty channel: https://ytube.io/3pZklisten to the bdge dynasty podcast: https://bityl.co/NzJ1bdge nfl trivia youtube channel: https://ytube.io/3jmJjoin the BDGE discord: https://discord.gg/77BxrqCF6Fsubscribe to the BDGE podcast | https://linktr.ee/bdgefollow me on the socials | https://linktr.ee/nickercolanoContact▪️ business inquiries | business@bdge.co▪️ customer support/help | help@bdge.co▪️ fantasy questions can go in our discord | https://discord.gg/AvpY3QJTAythis video is about (bdge,nick ercolano,fantasypros,fantasy flock,fantasy footballers,bdge fantasy football,2026 fantasy football,2026 fantasy football rankings,2026 fantasy football mock draft,fantasy football tiers 2026,2026 fantasy football week 3,fantasy football week 3,week 3 fantasy football rankings,week 3 fantasy football,week 3 start sit,week 3 fantasy football start em sit em,fantasy football week 3 start em sit em,week 3 starts,starts and sits week 3,start sit week 3)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

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No programa de hoje do CoutoCast, eu, Eduardo Couto, te conto como o aquecimento global, mesmo que pequeno, pode afetar a Indústria Nacional.Antes de ouvir não esqueça de Assinar o Feed do Blog e receber todos os conteúdos ou o Feed do CoutoCast no seu agregador! Não esqueça de seguir o CoutoCast no Twitter e Instagram!

Siptah & Chancellor Bay. The last years of Dynasty 19 are murky, with hints of disorder and violence. At the centre of affairs, the courtier Bay directed policy and controlled access to King Siptah. Pharaoh himself was sickly, possibly disabled. The power-shift culminated in a rather dramatic break... Music: Keith Zizza and Luke Chaos. Logo image: Siptah, from his tomb KV47 (Davis 1908). Bibliography Bierbrier, M. (2011). Bye-Bye Bay. In M. Collier & S. Snape (Eds.), Ramesside studies in honour of K. A. Kitchen (pp. 19–21). Rutherford. Černý, J. (1966). A note on the chancellor Bay. Zeitschrift Für Ägyptische Sprache Und Altertumskunde, 93, 35--39. Cooney, K. M. (2022). The New Kingdom of Egypt Under the Ramesside Dynasty. In D. T. Potts, N. Moeller, & K. Radner (Eds.), The Oxford History of the Ancient Near East, Volume III: From the Hyksos to the Late Second Millennium BC (pp. 251--366). Oxford University Press. https://doi.org/10.1093/oso/9780190687601.003.0027 Dodson, A. (2011). Fade to grey: The chancellor Bay, Éminence Grise of the late Nineteenth Dynasty. In M. Collier & S. Snape (Eds.), Ramesside Studies in Honour of K. A. Kitchen (pp. 145--158). Rutherford. Dodson, A. (2016). Poisoned Legacy: The Decline and Fall of the Nineteenth Egyptian Dynasty (Revised edn). American University in Cairo Press. Dodson, A. (2025). Siptah's leg and other stories. In A. F. Morris & H. Vogel (Eds.), Disability in ancient Egypt and Egyptology: All our yesterdays (pp. 214--220). https://doi.org/10.4324/9781003440369-17 Drenkhahn, R. (1980). Die Elephantine-Stele des Sethnacht und ihr historischer Hintergrund. Harrassowitz. Galassi, F. M., Habicht, M. E., & Rühli, F. J. (2017). Poliomyelitis in ancient Egypt? Neurological Sciences, 38, 375. https://doi.org/10.1007/s10072-016-2720-9 Goedicke, H. (1979). “Irsu, The Kharu” in Papyrus Harris. Wiener Zeitschrift Für Die Kunde Des Morgenlandes, 71, 1--17. https://www.jstor.org/stable/23858901 Grandet, P. (2000). L'execution du chancelier Bay: O.IFAO 1864. Bulletin de l'Institut Français d'Archéologie Orientale, 100, 339--345. https://www.ifao.egnet.net/bifao/100/14/ Habicht, M. E., Varotto, E., Galassi, F. M., & Pate, F. D. (2022). The elusive disease of pharaoh Siptah (19th dynasty, ca. 1200 BC): Old problems and future perspectives. Neurological Sciences, 43, 747–748. https://doi.org/10.1007/s10072-021-05649-6 Johnson, K. (2012). Transition and Legitimation in Egypt's Nineteenth and Twentieth Dynasties: A Study of the Reigns of Siptah, Tausret, and Sethnakht [Unpublished PhD. Thesis, University of Memphis]. https://digitalcommons.memphis.edu/etd/498 Johnson, K. L., & Brand, P. (2013). Prince Seti-Merenptah, Chancellor Bay, and the Bark Shrine of Seti II at Karnak. Journal of Egyptian History, 6, 19--45. https://doi.org/10.1163/18741665-12340001 Kahn, D. (2010). Who is meddling in Egypt's affairs? The identity of the Asiatics in the Elephantine Stele of Sethnakhte and the historicity of the Medinet Habu Asiatic war reliefs. Journal of Ancient Egyptian Interconnections, 2(1), 14--23. http://jaei.library.arizona.edu Leprohon, R. J. (2013). The Great Name: Ancient Egyptian Royal Titulary. Society of Biblical Literature. Lesko, L. H. (1966). A little more evidence for the end of the Nineteenth Dynasty. Journal of the American Research Center in Egypt, 5, 29–32. https://www.jstor.org/stable/40000169 Safronov, A. (2013). New titles of the Great Chancellor Bay. Journal of Egyptian Archaeology, 99, 290--295. https://www.jstor.org/stable/24644942 Schneider, T. (2003). Siptah und Beja: Neubeurteilung einer historischen Konstellation. Zeitschrift Für Ägyptische Sprache Und Altertumskunde, 130, 134--146. Servajean, F. (2014). Mérenptah et la fin de la XIXe dynastie. Pygmalion. Learn more about your ad choices. Visit megaphone.fm/adchoices

National parks, nature reserves, marine sanctuaries and Indigenous Protected Areas protect different environments and operate under different rules. What makes an Indigenous Protected Area different, and how can you find out whether you are welcome to visit? - Los parques nacionales, las reservas naturales, los santuarios marinos y las Áreas Indígenas Protegidas resguardan entornos diferentes y se rigen por normas distintas. ¿Qué distingue a un Área Indígena Protegida y cómo se puede saber si se permite su visita?Escucha SBS Spanish | Australia en español:Por radio o internet todos los días a la 1:00 pm (AEST) en https://www.sbs.com.au/language/spanish/esTambién nos encuentras en Apple Podcasts, Spotify y YouTubeExplora nuestra extensa colección de podcasts en https://www.sbs.com.au/audio/collection/podcasts-in-spanishSíguenos en Facebook e Instagram

Join Rob Pizzola and Clive Bixby for Sunday Reset, LIVE immediately following Sunday Night Football, as they break down everything that happened across Week 2 of the NFL season. From the biggest performances and surprises to the games that changed how we view teams heading into the rest of the season, Rob and Clive react to all the action and separate what matters from what might just be noise. Then, they turn the page to Week 3 with an early look at the betting lines, identifying teams, matchups and numbers worth keeping an eye on before the market fully takes shape.

O município de Orleans pretende ampliar e aprimorar a coleta seletiva e a destinação de resíduos plásticos a partir de experiências já desenvolvidas em outras regiões de Santa Catarina. O tema foi abordado pelo prefeito Fernando Cruzetta, durante entrevista ao programa Cruz de Malta Notícias desta segunda-feira (21). Na semana passada, uma comitiva de Orleans esteve no Consórcio Intermunicipal do Médio Vale do Itajaí (CIMVI), em Timbó, para conhecer iniciativas relacionadas à gestão de resíduos sólidos, coleta seletiva e economia circular. Segundo Cruzetta, participaram da visita o deputado Volnei Weber, representantes da Federação Catarinense dos Catadores, empresários da região e integrantes do Sindicato das Indústrias de Plástico, entre outros setores.

C'est un fonds unique au monde : plus de 1 700 films tournés en Afrique, par des réalisateurs du continent, de la diaspora mais aussi des Français. Une collection créée en 1961 par le ministère français de la Coopération au lendemain des Indépendances, devenue la Cinémathèque Afrique et placée sous l'égide de l'Institut français qui assure la sauvegarde, la restauration et la circulation des films. Que raconte ce fonds patrimonial exceptionnel des relations entre la France et les pays d'Afrique anciennement colonisés ? Comment décoloniser les imaginaires ? À qui appartiennent les films de la Cinémathèque Afrique et la question de leur restitution peut-elle se poser dans les mêmes termes que celle des œuvres d'art ? Et comment mieux les faire circuler en Afrique ?   Autant de questions que pose le livre Réparer le visible, qui paraît cette semaine, une coédition Institut français et Marest éditions. Nous recevons la chercheuse, programmatrice de films et commissaire d'exposition franco-béninoise Farah Clémentine Dramani-Issifou qui dirige cet ouvrage collectif. Ainsi que Catherine Ruelle, l'une des grandes voix de RFI, notamment avec l'émission « Cinéma d'aujourd'hui, cinéma sans frontières » et co-autrice d'un rapport d'expertise de la Cinémathèque Afrique en 2023. Et Maxime Grember, auteur du podcast Cinéastes d'Afrique, produit par RFI en partenariat avec la Cinémathèque Afrique, et réalisé justement sur des films emblématiques du fonds.

Chris Welsh, Pat Fitzmaurice, and Andrew Erickson break down the biggest NFL Week 2 storylines, starting with Nico Collins’ hamstring injury, Jordan Mason landing on IR, Aaron Jones’ expanded opportunity, and the latest on Ladd McConkey and Zay Flowers. Then it’s on to the week’s biggest games: Vikings-Bears, Jaguars-Broncos, Seahawks-Cardinals, Colts-Chiefs, and Rams-Giants. The guys dig into Caleb Williams vs. Brian Flores, Trevor Lawrence and Bo Nix, Kenneth Walker, Jonathan Taylor, Matthew Stafford, Jackson Dart, Justin Jefferson, and more. Finally, the crew makes its bold Week 2 calls, including a potential Shedeur Sanders takeover in Cleveland, Bengals-Texans, and a Vikings upset pick before revealing the teams and players they’ll be watching most closely this weekend. Timestamps: (May be off due to ads) Intro - 0:00:00 Nico Collins - 0:00:40 Jordan Mason - 0:07:20 Zay Flowers & Ladd McConkey - 0:12:15 Polymarket - 0:14:55 MIN VS CHI - 0:15:57 JAX vs DEN - 0:20:55 SEA vs AZ - 0:28:38 IND vs KC - 0:33:10 LAR vs NYG - 0:37:01 Tailgate Jersey Giveaway - 0:42:28 Make The Call - 0:43:31 One Thing to Watch - 0:51:24See omnystudio.com/listener for privacy information.

In Dänemark wird ein CO2-Speicher unter dem Meer eingeweiht. Eine Schülerin hat eine App entwickelt, die Ehrenämter vermittelt. Und Dino-Kacke hat Forschern ein spannendes Geheimnis preisgegeben. Von Jana Magdanz.

Manufacturability challenges in biotech are becoming more complex as therapies become more potent, formats diversify, and timelines compress across the industry.On this episode, David Brühlmann sits down with Sigma Mostafa, Chief Scientific and Technology Officer at KBI Biopharma. Sigma brings deep expertise in early-stage CMC decision-making and has guided countless programs—from upstart startups to established pipelines—through the traps and trade-offs of process development. Her ground-floor perspective spans in silico modeling, innovative cell line engineering, and the gritty realities of tech transfer.Key topics discussed:Practical advice for startups on selecting robust cell lines and avoiding long-term lock-in to problematic platforms (03:07)Managing risks in process development, such as high oxygen demand and filter loading, before tech transfer to manufacturing (04:47)The value of pressure testing bioprocesses at scale and identifying potential failure modes, including filter clogging and narrow feeding windows (07:41)Balancing speed, robustness, and regulatory expectations when advancing new molecules (09:23)How fast-tracking from transfection to IND is changing timelines, and the associated risks of accelerated development (09:54)Trends and caution in applying AI and in silico tools to protein and process modeling, and the limits of digital solutions (12:01)What first-time founders need to get right, including early analysis of molecular issues and careful cell line selection (15:48)Shifting modality trends—growing numbers of ADCs/XDCs, more complexity, and the move toward smaller scale and more potent molecules (16:55)The overarching lesson: invest early in the areas you cannot change later—especially cell line and understanding of molecule challenges (18:23)Smart insight: Startup founders often wonder which fires to fight first. Sigma's advice: focus on deep molecular assessment and making informed, scalable cell line choices above all else. These are the “few things you cannot change later” and the investments that separate enduring programs from cautionary tales.This episode unpacks what that means in practice and where speed and robustness pull against each other. If it resonated, these conversations expand the picture: how to spot manufacturable candidates early, how in silico tools predict stability and aggregation before the lab, and which early CMC decisions quietly become permanent.Episodes 123 - 124: Manufacturability: Why Most Protein Candidates Fail (And How to Pick Winners Early) with Susan SharfsteinEpisodes 213 - 214: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe LicariEpisodes 231 - 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri KornmannEpisodes 103 - 104: One-Stop Shop vs. Specialist CDMO: A Scientist's Guide to CDMO Selection with Sigma MostafaConnect with Sigma Mostafa: Linkedin: https://www.linkedin.com/in/sigma-mostafa-79180817 KBI website: https://www.kbibiopharma.comFree 5-day email course, The CMC Failure Chain: the five recurring CMC mistakes that put your promising program at risk → Get it hereSupport the show

Dans cet épisode, je reçois Frédérik Lacharité, ancien programmeur devenu courtier hypothécaire, investisseur et animateur du podcast Indépendance financière et hypothèque.Nous discutons de son parcours vers l'indépendance financière, mais surtout de sujets qui reviennent souvent lorsqu'on possède une propriété et qu'on souhaite accélérer la croissance de son patrimoine.On parle notamment de Manœuvre Smith, de refinancement hypothécaire, d'utilisation de l'équité de sa propriété pour investir, de levier financier et des risques associés à ces stratégies.Frédérik explique aussi dans quelles situations un refinancement peut être pertinent, les erreurs qu'il voit régulièrement chez les propriétaires et les éléments à considérer avant de transformer une partie de sa dette hypothécaire en dette d'investissement.Nous abordons également plusieurs questions concrètes :Est-ce que la Manœuvre Smith convient à tout le monde?À quel moment est-il pertinent de refinancer sa propriété?Jusqu'où peut-on utiliser l'effet de levier sans prendre trop de risques?Faut-il prioriser le CELI et le REER avant d'investir avec de l'argent emprunté?Quelle place l'hypothèque peut-elle occuper dans une stratégie d'indépendance financière?Un échange très concret sur l'hypothèque, l'investissement et l'utilisation stratégique de la dette.Attention : les stratégies discutées dans cet épisode ne conviennent pas à toutes les situations. L'utilisation du levier financier comporte des risques et peut avoir des conséquences fiscales importantes. Faites vos propres vérifications et consultez les professionnels appropriés au besoin.

¡QUE RUEDE LA PELOTA!

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into a series of significant strides and strategic maneuvers reshaping the landscape of healthcare and drug development. Kicking things off, GlaxoSmithKline (GSK) has made headlines with its acquisition of Chimagen Biosciences' trispecific T cell engager technology, targeting multiple myeloma. This move, valued at up to $750 million, highlights GSK's strategic focus on expanding its oncology pipeline through cutting-edge immunotherapeutic approaches. Trispecific T cell engagers are an emerging class of biologics that bind to three different targets simultaneously, effectively arming the immune system to recognize and destroy cancer cells more efficiently. This acquisition not only strengthens GSK's position in the competitive oncology market but also addresses a significant need for more effective multiple myeloma treatments. In parallel, Curium has achieved a notable milestone with the FDA approval of Bexlutry, a radioligand therapy for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). This therapy utilizes radioactive isotopes attached to molecules that specifically target cancer cells, delivering radiation directly while minimizing harm to healthy tissue. The approval of Bexlutry is a crucial development in oncologic care, expanding treatment options for patients dealing with complex and heterogeneous tumors. It underscores the growing role of targeted radiotherapies in providing precision medicine solutions. On the financial front, Electra Therapeutics is gearing up for an initial public offering (IPO) to raise $325 million. The proceeds are intended to advance its late-stage clinical trials for severe hemophagocytic lymphohistiocytosis (SHLH), a rare autoimmune condition. This move reflects a broader trend among biotech companies turning to public markets to support niche therapeutic areas with high unmet needs and potential orphan drug status benefits. Turning to clinical advancements, Corbus Pharmaceuticals has reported encouraging Phase 1b data for CRB-913, which employs CB1 inverse agonism in combating obesity. By modulating endocannabinoid activity linked to appetite and energy balance, this approach offers a promising direction for managing metabolic disorders. Simultaneously, CSL Seqirus has shared Phase 3 results showcasing the superior efficacy of its MF59-adjuvanted cell-based quadrivalent influenza vaccine in older adults, highlighting ongoing innovations in vaccine technologies tailored for vulnerable populations. The FDA's regulatory landscape is also evolving with the launch of Operation Trialblazer. This initiative seeks to streamline early-phase U.S. clinical trials through expedited IND application processes, facilitating faster transitions from research to clinical applications and fostering innovation by reducing bureaucratic hurdles. Meanwhile, the FDA is preparing for potential psychedelic medicine approvals, ensuring robust oversight frameworks are in place as these therapies near market availability. Yet, as always in drug development, challenges persist. Novo Nordisk's decision to terminate its GLP-1 obesity drug partnership with Ascendis following unsatisfactory results exemplifies the inherent risks even promising preclinical data can present. Similarly, setbacks faced by Axoltis Pharma and Eli Lilly with their neurological and metabolic candidates reinforce the complexities of translating scientific hypotheses into viable therapies. Sanofi has taken significant strategic steps as well by divesting 20 older medicines and three manufacturing sites to Cheplapharm. This decision aligns with Sanofi's focus on innovation under CEO Paul Hudson's leadership and allows the company to reallocate resources towards groundbreaking therapies. In diagnostic advances, the FDA's approval of Telix's Pixclara marks a breakthrough for brain cancer imaging. Being the first FET-PET imaging drug approved for gliomas, Pixclara could significantly enhance diagnostic accuracy and treatment planning for these challenging tumors. These developments underscore a transformative period where scientific innovation is paired with strategic regulatory adjustments to navigate complex market dynamics. As companies continue adapting to these changes, their ability to innovate while addressing safety and efficacy concerns will be critical in advancing therapeutic frontiers and improving patient outcomes across diverse medical landscapes. As always, we'll be here at Pharma Daily to keep you informed on these pivotal changes shaping our industry's future. Thank you for tuning into today's episode of Pharma Daily. Keep innovating and stay informed!Support the show

Merci à notre commanditaire ProCafetière :  https://tinyurl.com/procafetiere-jerr Pour obtenir le Café Whats Up : https://procafetiere.ca/collections/cafe-vrac/products/espresso-whats-up-cafe-vrac Utilise le code JERR20 pour 20% de rabais sur le sac Whats Up ;) Merci à notre commanditaire Nettoyage DC Plus, pour plus d'info : https://www.facebook.com/NettoyageDCPlus/ https://nettoyagedcplus.ca/ Un énorme MERCI à mon ami Mathieu Bock-Côté pour être venu nous parler de l'élection la plus importante de notre histoire. Le sociologue dresse un portrait des cinq formations politiques qui se préparent à s'affronter lors de la prochaine campagne électorale : - Le bilan DÉSASTREUX de la CAQ - Les tentatives MÉDIOCRES du PLQ - Les Conservateurs qui jouent la carte de la révolte ANTI-FISCALE - Les PIÈGES à éviter pour le PQ - Québec solidaire arrivé au TERME de son parcours Une discussion percutante, des analyses franches et… disons que Mathieu ne leur a pas fait de cadeaux! Enregistré le 13 août 2026. Chapitre : 00:00 La CAQ et Christine Fréchette 24:30 Parti Québécois 38:07 Fling-Flang  44:43 Parti Libérale du Québec 53:00 Indépendance 1:02:00 Québéc Solidaire 1:04:23 Parti Conservateur du Québec 1:07:07 Élection de la dernière chance 1:11:05 Louis Morissette 1:21:00 Extrême-centre Pour suivre Mathieu Bock-Coté sur les RS : https://x.com/mbockcote https://www.facebook.com/mathieu.bockcote.7/ Pour lire les articles de Mathieu sur le Journal de Montréal : https://www.journaldemontreal.com/opinions/mathieu-bock-cote Pour devenir membre et supporter le Whats Up Podcast : https://www.patreon.com/whatsuppodcast  Merci les patreon !!  Site web officiel : https://jerrallain.ca Pour suivre Jerr sur Instagram :  https://www.instagram.com/jerr_allain/  Pour suivre Jerr sur facebook : https://www.facebook.com/JerrAllainofficiel Contact : jerr.production@gmail.com  Pour vous abonner à mon Infolettre :  http://eepurl.com/hvpnhj

Tausret, Siptah, Bay, and the case of Paneb. By 1210 BCE, the southern rebellion was dying down, but trouble was far from over. The courtier Bay appears on the scene, first as an agent of Sety II, then as a "kingmaker" in his own right. Tausret increases her power, becoming a regent figure (like Hatshepsut). The young ruler Siptah, physically enfeebled and of uncertain heritage, provides a veil of legitimacy for a new triumvirate. Meanwhile, in Deir el-Medina, the foremen/chiefs Hay and Paneb deal with serious allegations... [WARNING: Starting at 23:01, episode contains content that may not be suitable for all listeners] Logo image: Winged Ma'at in KV47, tomb of Siptah, by E. Harold Jones 1910 (MMA). Bibliography Aldred, C. (1963a). The Parentage of King Siptaḥ. The Journal of Egyptian Archaeology, 49, 41–48. https://doi.org/10.2307/3855698 Aldred, C. (1963b). Valley Tomb No. 56 at Thebes. The Journal of Egyptian Archaeology, 49, 176–178. https://doi.org/10.2307/3855714 Altenmüller, H. (1989). Untersuchungen zum Grab des Bai (KV13) im Tal der Könige von Theben. Göttinger Miszellen, 107, 43--54. Bartos, F. (2023). The Official Titles wb3 nswt ‘royal wb3' and wdpw nswt ‘royal wdpw' and the Function of their Holders in the New Kingdom. Beckerath, J. von. (1962). Queen Twosre as guardian of Siptaḥ. Journal of Egyptian Archaeology, 48, 70--74. Bierbrier, M. L. (2000). Paneb Rehabilitated? In R. J. Demarée & A. Egberts (Eds.), Deir el-Medina in the Third Millennium AD: A Tribute to Jac. J. Janssen (pp. 51--54). Černý, J. (1966). A note on the chancellor Bay. Zeitschrift Für Ägyptische Sprache Und Altertumskunde, 93, 35--39. Cooney, K. M. (2022). The New Kingdom of Egypt Under the Ramesside Dynasty. In D. T. Potts, N. Moeller, & K. Radner (Eds.), The Oxford History of the Ancient Near East, Volume III: From the Hyksos to the Late Second Millennium BC (pp. 251--366). https://doi.org/10.1093/oso/9780190687601.003.0027 Davies, B. G. (1997). Egyptian Historical Inscriptions of the Nineteenth Dynasty. Davis, T. M. (1908). The Tomb of Siphtah: The Monkey Tomb and the Gold Tomb. https://ia904605.us.archive.org/22/items/tombofsiphtahmon04davi/tombofsiphtahmon04davi.pdf Dodson, A. (2011). Fade to grey: The chancellor Bay, Éminence Grise of the late Nineteenth Dynasty. In M. Collier & S. Snape (Eds.), Ramesside Studies in Honour of K. A. Kitchen (pp. 145--158). Dodson, A. (2016). Poisoned Legacy: The Decline and Fall of the Nineteenth Egyptian Dynasty (Revised edn). Dodson, A. (2025). Siptah's leg and other stories. In A. F. Morris & H. Vogel (Eds.), Disability in ancient Egypt and Egyptology: All our yesterdays (pp. 214--220). https://doi.org/10.4324/9781003440369-17 Gardiner, A. (1958). Only One King Siptaḥ and Twosre Not His Wife. The Journal of Egyptian Archaeology, 44, 12–22. https://doi.org/10.2307/3855059 Gardiner, A. H. (1912). The Stele of Bilgai. Zeitschrift Für Ägyptische Sprache Und Altertumskunde, 50, 49--57. Johnson, K. (2012). Transition and Legitimation in Egypt's Nineteenth and Twentieth Dynasties: A Study of the Reigns of Siptah, Tausret, and Sethnakht [Unpublished PhD. Thesis, University of Memphis]. https://digitalcommons.memphis.edu/etd/498 Johnson, K. L., & Brand, P. (2013). Prince Seti-Merenptah, Chancellor Bay, and the Bark Shrine of Seti II at Karnak. Journal of Egyptian History, 6, 19--45. https://doi.org/10.1163/18741665-12340001 Safronov, A. (2013). New titles of the Great Chancellor Bay. Journal of Egyptian Archaeology, 99, 290--295. https://www.jstor.org/stable/24644942 Schneider, T. (2003). Siptah und Beja: Neubeurteilung einer historischen Konstellation. Zeitschrift Für Ägyptische Sprache Und Altertumskunde, 130, 134--146. Servajean, F. (2014). Mérenptah et la fin de la XIXe dynastie. Wilkinson, R. H. (Ed.). (2012). Tausret: Forgotten Queen and Pharaoh of Egypt. Learn more about your ad choices. Visit megaphone.fm/adchoices

Merci à Patrick Baronnet et à sa femme de nous avoir accueillis chez eux !Patrick et Brigitte vivent dans leur maison depuis plus de 50 ans et l'ont rendue 100 % autonome. Indépendants en électricité et en eau, ils ne paient plus aucune facture énergétique depuis 40 ans. Découvrez leur incroyable maison et les nombreux trésors qui s'y cachent !

U.S. Air Force Senior Master Sgt. Henry Hatfield and Airman 1st Class Joel McChesney discuss the traffic management office (TMO) with Senior Master Sgt. Leslie Kaiser at the 122nd Fighter Wing Fort Wayne, Ind., Feb. 28, 2025. TMO schedules and coordinates passenger and cargo travel and manages inbound and outbound military equipment, aircraft parts and base supplies (U.S. Air National Guard audio by Senior Master Sgt. Leslie Kaiser)

Join David Craig, Co-Founder, President, and CEO of Sarcomatrix Therapeutics, for a masterclass on disrupting the traditional pharmaceutical development playbook. Rare neuromuscular diseases have long been underserved—not due to a lack of scientific potential, but because legacy pharma cost structures fail to scale to small patient populations. Drawing on 30 years of drug development leadership at industry giants like Amgen, Gilead, and Portola, David shares how Sarcomatrix is testing a lean, hyper-disciplined operating model to translate university research into clinical-grade therapeutics without the typical overhead waste.

ALSO: Schools look for cost cuts amid rising diesel prices, TSA opens gate access for some non-travelers at IND airport, Trump promises $5,000 ‘dividend' to citizens, the impact of 9/11 on local news, and Center Grove soccer in the Zone Athlete of the Week.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Confira no Morning Show desta quarta-feira (09): O ministro Flávio Dino, do Supremo Tribunal Federal determinou nesta quarta-feira (09), a reintegração de Andrei Rodrigues ao cargo de diretor-Geral da Polícia Federal e de Leandro Almada da Costa à chefia da Diretoria de Inteligência Policial da corporação. A decisão atende a um pedido de Andrei Rodrigues dentro de um processo que já tramitava no STF. A medida suspende os efeitos da decisão anterior proferida por Mendonça, que havia decretado o afastamento preventivo dos dois delegados a pedido do Partido Novo. Segundo a análise da professora de direito da PUC - SP, Gabriela Zancaner, o Supremo Tribunal Federal está dividido em “duas alas” e que não vê uma saída fácil para o impasse. A professora ainda afirma que “os ministros envolvidos deveriam se afastar da pauta” e deixar que outros membros do Supremo toquem o caso Vorcaro. Um documento assinado por 151 personalidades da mídia e do mercado financeiro, chamado “Pela lei e pelo Brasil” exige a moralização do Supremo Tribunal Federal. Dentre os signatários estão André Lara Resende, Pérsio Arida e Luciano Huck. O ministro Alexandre de Moraes diminuiu em dois meses a pena de Débora Rodrigues dos Santos, conhecida como Débora do Batom pela realização de cursos de ressocialização e leitura de livros no cárcere. A juíza Dra. Jacqueline Valles avalia a decisão do ministro do STF Flávio Dino de reintegrar o delegado-geral da polícia federal Andrei Rodrigues e as manifestações de ex-ministros do Supremo. A juíza Valles ainda afirma que a Corte não está bem representada. Começa nesta quarta-feira (09) o prazo para a prestação de contas parcial dos candidatos nas eleições de 2026. Apenas os políticos que disputam a Presidência da República já gastaram R$ 74 milhões em campanhas no rádio, TV e em eventos de rua. O presidente do Supremo Tribunal Federal, Edson Fachin, suspendeu a sessão em plenário prevista para esta quarta-feira (09) em meio à crise institucional que tomou o Tribunal. Fachin também deu 72 horas para o ministro Mendonça explicar a exoneração de Andrei Rodrigues. O presidente da Confederação Nacional das Indústrias, Ricardo Alban, publicou uma nota pedindo por bom senso e responsabilidade na condução dos rumos do Brasil. O presidente da CNI afirma que a crise no STF não pode travar a economia brasileira. A pesquisa BTG/Nexus divulgada nesta terça-feira (08) aponta que para 52% dos brasileiros, a economia está ruim. Para 30% a economia está regular e para 16% a economia está ótima ou boa. O presidente Lula (PT) fez uma declaração nas redes sociais afirmando que o “o povo brasileiro merece explicações” e pediu a quebra de sigilo de todos os envolvidos no caso Master. Lula finalizou dizendo que “o Brasil merece saber a verdade”. A Ordem dos Advogados do Brasil no Distrito Federal (OAB-DF) abriu nesta terça-feira (08) um processo ético-disciplinar contra o escritório Barci e Barci Sociedade de Advogados, da família do ministro do Supremo Tribunal Federal (STF) Alexandre de Moraes. Segundo a OAB-DF, a abertura foi determinada pelo presidente da entidade, Paulo Maurício Siqueira (Poli), e anunciada durante uma sessão extraordinária do Conselho Pleno. Essas e outras notícias você confere no Morning Show.

✅ Soutiens LIMIT pour qu'on puisse rester un média Indépendant : https://fr.tipeee.com/limit/https://paypal.me/limitmediaDans cette vidéo on aborde le paradoxe de l'énergie chinoise, à la fois le plus grand pollueur et le plus avancé dans le monde sur les énergies renouvelables. La Chine est-elle vraiment la 1ère grande civilisation écologique, ou c'est un mirage ?Merci à Infomaniak de nous soutenir, vous pouvez profiter du code LIMIT50 pour leur offre via ce lien : https://www.infomaniak.com/fr/ksuite/myksuite?utm_source=youtube&utm_medium=social&utm_campaign=limit-media&utm_content=my-ksuite&utm_term=69d4d4192cafb

Between 1215 and 1211 BCE, Egypt was divided. A rebellion in the south, launched by Amen-messe "Born of Amun" disrupted the succession of Sety II, son of Merneptah. Records from this shadowy period hint at violence and corruption in Waset/Luxor, as the usurper took control and established a new regime. The impact of this conflict would have long-lasting ramifications for the 19th Dynasty... Music: Luke Chaos. Logo: An unnamed statue head from Karnak, probably depicting Sety II or Amenmesse (Metropolitan Museum of Art, public domain). Was Amenmesse the Viceroy Messuy? Below are scenes from Amada in Nubia, where Messuy carved scenes of himself before royal cartouches. Prof. Aidan Dodson suggests that the Viceroy has cobra/uraei on his forehead, though other scholars suggest this is mere weathering. What do you think? Photos (high-res) https://www.flickr.com/photos/184518985@N04/ Bibliography Brand, P. J. (2009). Usurped Cartouches of Merenptah at Karnak and Luxor. In P. J. Brand & L. Cooper (Eds.), Causing His Name to Live: Studies in Egyptian Epigraphy and History in Memory of William J. Murnane (pp. 29–48). Brill. http://history.memphis.edu/murnane/Brand.pdf Caminos, R. A. (1974). The new-kingdom temples of Buhen. Egypt Exploration Society. Černý, J. (1929). Papyrus Salt 124 (Brit. Mus. 10055). The Journal of Egyptian Archaeology, 15(3/4), 243–258. https://doi.org/10.2307/3854120 Cooney, K. M. (2022). The New Kingdom of Egypt Under the Ramesside Dynasty. In D. T. Potts, N. Moeller, & K. Radner (Eds.), The Oxford History of the Ancient Near East, Volume III: From the Hyksos to the Late Second Millennium BC (pp. 251--366). Oxford University Press. https://doi.org/10.1093/oso/9780190687601.003.0027 Dodson, A. (2016). Poisoned Legacy: The Decline and Fall of the Nineteenth Egyptian Dynasty (Revised edn). American University in Cairo Press. Hopper, R. W. (2010). The Monuments of Amenmesse and Seti II: A Historical Inquiry [Unpublished PhD. Thesis]. The University of Memphis. Iskander, S. (2002). The Reign of Merneptah [Unpublished PhD. Thesis]. New York University. Kitchen, K. A. (1987). The Titularies of the Ramesside Kings as Expression of their Ideal Kingship. Annales Du Service Des Antiquités de l'Égypte, 71, 131--141. https://archive.org/details/ASAE-71-1987 Krauss, R. (1976). Untersuchungen zu König Amenmesse (1. Teil). Studien Zur Altägyptischen Kultur, 4, 161--199. https://www.jstor.org/stable/25150008 Krauss, R. (1977). Untersuchungen zu König Amenmesse (2. Teil). Studien Zur Altägyptischen Kultur, 5, 131--174. https://www.jstor.org/stable/44324535 Krauss, R. (1997). Untersuchungen zu König Amenmesse: Nachträge. Studien Zur Altägyptischen Kultur, 24, 161--184. https://www.jstor.org/stable/25152736 Krauss, R. (2000). Moïse le pharaon (N. Baum, Trans.). Editions du Rocher. Lefébure, E. (1886). Les hypogées royaux de Thèbes (Band 1): Le tombeau de Séti Ier. Libraire de la Societe Asiatique. http://digi.ub.uni-heidelberg.de/diglit/lefebure1886bd1 Leprohon, R. J. (2013). The Great Name: Ancient Egyptian Royal Titulary. Society of Biblical Literature. Schneider, T. (2011). Conjectures About Amenmesse: Historical, Biographical, Chronological. In M. Collier & S. Snape (Eds.), Ramesside Studies in Honour of K. A. Kitchen (pp. 445--451). Rutherford. https://www.academia.edu/6374977/Conjectures_about_Amenmesse_Historical_Biographical_Chronological_in_Ramesside_Studies_Festschrift_Kenneth_A_Kitchen_Bolton_Rutherford_Press_2011_445_451 Servajean, F. (2014). Mérenptah et la fin de la XIXe dynastie. Pygmalion. Sourouzian, H. (2019). Catalogue de la statuaire royale de la XIXe dynastie. Institut français d'archéologie orientale. https://www.ifao.egnet.net/publications/catalogue/9782724707571/ Yurco, F. J. (1979). Amenmesse: Six statues at Karnak. Metropolitan Museum Journal, 14, 15--31. http://www.jstor.org/stable/pdfplus/1512735.pdf Learn more about your ad choices. Visit megaphone.fm/adchoices

Matriarch Movement Podcast — Season 6: Indigenous Voices of This Generation This episode, host Shayla Oulette Stonechild, sits down with Daniela Riojas — a medicine keeper, educator, musician, and artist whose roots stretch from the Coahuiltecan lands on the Texas-Mexico border to the Peruvian Amazon, where she trained under Shipibo and Ashaninka lineage holders and was initiated into ceremonial plant medicine work. Daniela is the founder of Indígena Medicina, creating sacred containers for healing rooted in Indigenous knowledge, plant medicine, and ceremony. Daniela and Shayla trace her path from growing up "siphoned" between two identities on the border, to activism in San Antonio, to the grief and long search that led her to her teachers in Peru. She opens up about her mother's passing and the ancestral womb work that initiated her deeper into her medicine path, what a dieta actually involves, and how Icaros - the songs of the plants - become a living technology for healing in ceremony. The conversation also turns practical: how to responsibly vet a ceremony facilitator amid the current plant-medicine boom, how she stays grounded through physical discipline and nutrition, and her advice for anyone trying to reconnect with lineage, land, or spirit when the elders and acces s aren't there. They close on matriarchy -Daniela's mother, her sisters, and the mentors who shaped how she leads with what she calls "heart-led advocacy." 01:11 — Guest introduction: Daniela Riojas, medicine keeper and founder of Indígena Medicina 02:31 — Daniela's roots: born in Eagle Pass, Texas, connected to the Coahuiltecan people 04:08 — Growing up "siphoned" between two identities on the Texas-Mexico border 05:31 — Activism in San Antonio and fighting for Indigenous voices in the story of the Alamo 07:00 — Shayla on fragmentation, residential schools, and reclaiming pride as a younger generation 08:00 — Daniela's advice for reconnecting to elders and spirit without direct access 12:39 — What a curandera is and how the term is used in her Peruvian lineage 15:21 — What a dieta actually involves — from 8 days to years-long processes 20:40 — Why she began dieting: her mother's passing and the womb work that followed 24:22 — Receiving the Icaros — the "songs of the plants" — as a form of coding technology 28:06 — How she holds the responsibility of space-holding without burning out 30:34 — Physical discipline and nutrition as grounding practices for ceremony work 34:19 — Navigating cultural appropriation and how to vet a ceremony facilitator 37:22 — Lateral violence and protocols for creating safety within community containers 41:47 — Daniela's mentorship for stepping into confidence, power, and self-expression 44:09 — Defining matriarchy: her mother, her sisters, and mentor Miriam Hosny 50:08 — Where to find Daniela: her website, Instagram, and upcoming European tour Follow Daniela Riojas at Intikhana for details on her mentorship, retreats, and upcoming tours. @danielariojas https://www.intikhana.com/ https://linktr.ee/danielariojas Learn more about your ad choices. Visit megaphone.fm/adchoices

O "Ulrich Responde" é uma série de vídeos onde analiso os recentes acontecimento da economia no Brasil e no Mundo e respondo perguntas enviadas por membros do canal e seguidores, abordando temas de economia, finanças e investimentos. Oferecemos uma análise profunda, trazendo informações para quem quer entender melhor a economia e tomar decisões financeiras mais informadas.Neste vídeo, comento os recentes desdobramentos políticos e institucionais no Brasil, a crise interna no STF com os atritos entre ministros e a repercussão do caso Banco Master. No cenário internacional, analiso a surpresa nos dados de emprego dos EUA (Non-Farm Payroll), a perspectiva para os juros pelo Federal Reserve, além dos movimentos na indústria de IA e a perda de competitividade na Europa. Para fechar, respondo às dúvidas enviadas pela comunidade sobre política, economia, investimentos e a movimentação recente das ações da OranjeBTC.00:00 - Evento em Buenos Aires e o debate de ideias na América Latina01:15 - A gravidade da crise institucional e política no Brasil03:00 - Escândalo Banco Master e o inquérito no STF05:15 - Reações na Corte e a repercussão política07:25 - Expectativa para as manifestações de 7 de Setembro08:26 - Payroll acima do esperado nos EUA e impacto nos juros do Fed10:15 - Reação dos mercados e preço do Bitcoin11:34 - Aquisição da Hugging Face pela Nvidia e avanço da Anthropic12:47 - Crise migratória em Ceuta e protestos na Espanha14:35 - Indústria alemã: semana de 40 horas e cortes na Volkswagen17:16 - Perguntas: Apoio libertário a candidaturas políticas18:18 - Perguntas: O sistema brasileiro já esteve pior?20:19 - Perguntas: Liberdade econômica e gastos: China vs. Brasil22:05 - OranjeBTC: Fato relevante, pressão vendedora e novo ETF23:58 - Perguntas: Ainda há esperança no Brasil?25:01 - Perguntas: Morar na Suíça ou nos Estados Unidos?26:01 - Perguntas: Avanço dos carros elétricos chineses e câmbio26:44 - Perguntas: Por onde começar um reboot do sistema?27:10 - Perguntas: Destinos para viver fora do Brasil28:13 - Considerações finais

✅ Soutiens LIMIT pour qu'on puisse rester un média Indépendant : https://fr.tipeee.com/limit/https://paypal.me/limitmediaL'été 2026 était-il un avant-goût de ce qui nous attend ?Canicules, sécheresse, méga-feux… Cet été, la France a été frappée par des événements climatiques exceptionnels. Mais sommes-nous réellement préparés à ce qui arrive ?Avec Ilian Moundib, expert en résilience climatique, nous revenons sur les conséquences de cet été sur notre santé, notre travail, notre agriculture, nos infrastructures et nos forêts.Car face au changement climatique, nous ne sommes pas tous égaux : selon l'endroit où l'on vit, son logement ou son métier, les risques peuvent être radicalement différents.Alors, qu'est-ce qui a réellement craqué cet été ? Et surtout, sommes-nous prêts pour la suite ?Lien du livre d'Ilian : https://www.ombres-blanches.fr/product/2434372/moundib-ilian-s-adapter-au-changement-climatique-fake-or-not

Neste episódio de O Tempo Virou, Giovanna Nader conversa com Daya Molina, estilista, pesquisadora, fundadora do coletivo Indígenas Moda BR e criadora da NALIMO, sobre o que a moda pode nos ensinar sobre clima, território e futuro. A partir de suas raízes Fulni-ô e Aymará e da convivência com gerações de mulheres costureiras e artesãs, Day fala sobre descolonizar a moda na prática e recuperar outros modos de criar, produzir e se relacionar com ostempos da natureza.a

Confira na edição do Jornal da Record desta segunda-feira (31): Jogadores do Vasco e do Vila Nova na mira da polícia, em operação que investiga tráfico e lavagem de dinheiro. Criminosos já usam programas caseiros para burlar sistemas de reconhecimento facial. Justiça decreta falência de grupo que controla refinaria envolvida em fraudes bilionárias. Ministro do Desenvolvimento, Indústria e Comércio do Brasil diz que EUA estão abertos para fechar um acordo comercial que substitua o tarifaço. TSE proíbe candidato Renan Santos de participar de debates e fazer propaganda nas redes. E o fim de uma era: Lionel Messi anuncia aposentadoria da seleção argentina.

No 3 em 1 desta segunda-feira (31), o destaque foi que o ministro do Supremo Tribunal Federal Dias Toffoli suspendeu a campanha digital do candidato à Presidência Renan Santos (Missão). A decisão proíbe o candidato de utilizar as redes sociais para fazer campanha e também barra sua participação em debates e sabatinas. Reportagem: André Anelli. Uma nova pesquisa BTG/Nexus aponta um crescimento significativo do candidato Augusto Cury (Avante), que alcançou dois dígitos ao registrar 11% das intenções de voto no primeiro turno. O levantamento também indica uma queda nos números de Flávio Bolsonaro (PL), sinalizando a migração de uma parcela do eleitorado. Em sabatina no 3 em 1, o candidato ao governo de Santa Catarina, Marcelo Brigadeiro (Missão) entrou em detalhes sobre quais são os seus planos para a gestão estadual caso vença a corrida. O candidato trouxe propostas para melhorias na infraestrutura estadual e na segurança pública e também na mitigação de problemas relacionados às mudanças climáticas. O Ministro do Supremo Tribunal Federal (STF) Dias Toffoli, estabeleceu um prazo de 24 horas para o candidato Renan Santos prestar esclarecimentos sobre perfis nas redes sociais. A pena prevê interferência da candidatura e multa diária de R$ 50 mil reais. Os ministros das Relações Exteriores, Mauro Vieira, e também do Desenvolvimento e Indústria, Márcio Elias Rosa, se reuniram com representantes dos Estados Unidos para tratar do tarifaço. Em nota, o governo afirmou que não concorda com o tratamento discriminatório e injusto por parte do governo norte-americano em relação aos produtos brasileiros. Reportagem: André Anelli. Aliados de Lula (PT) esperam que o atual presidente tenha um encontro reservado com o presidente norte-americano Donald Trump na assembléia geral da ONU, que ocorrerá em setembro. A expectativa é de que um encontro entre os líderes possa trazer avanços significativos nas tratativas com relação ao tarifaço. Reportagem: João Vitor Revedilho. A nova pesquisa realizada da AtlasIntel/Bloomberg revela um avanço significativo para o candidato Augusto Cury (Avante), que ocupa agora o terceiro lugar nas intenções de voto. O levantamento aponta que a candidatura ganha tração entre eleitores indecisos e aqueles que buscam alternativas à polarização política, alterando a dinâmica das alianças no cenário eleitoral. Tudo isso e muito mais você acompanha no 3 em 1. Learn more about your ad choices. Visit megaphone.fm/adchoices

Nvidia (NVDA) represents 18% of the S&P 500's (SPX) incoming growth and Micron (MU) represents 14%, says Liz Ann Sonders of Charles Schwab. She points to both stocks as a key signal that growth remains concentrated in the AI trade. Michael Townsend looks ahead to Jackson Hole and how Fed Chair Kevin Warsh will drop hints to the interest rate outlook. In D.C., Congress faces a contentious couple months as voters keep their eyes on midterm elections.

Convidadas: Stella Fontes, editora-assistente da editoria Empresas, e Adriana Mattos, repórter especial de Varejo, Indústria e Consumo, ambas do jornal Valor Econômico. A Braskem protocolou nesta segunda-feira (24) um pedido de recuperação extrajudicial para reestruturar cerca de R$ 56 bilhões em dívidas. Na semana passada duas importantes empresas do varejo nacional recorreram à recuperação judicial: a Casas Bahia, para reestruturar dívidas de R$ 17 bilhões, e a Marabraz, com um passivo de R$ 140 milhões. São empresas que se somam a outras grandes redes que buscaram recuperações judiciais ou extrajudiciais nos últimos anos: Tok&Stok, Grupo Pão de Açúcar, Grupo Dia, St. Marche, entre outros. São companhias que enfrentam um cenário econômico desafiador, de juros altos, menor oferta de crédito e mudança de comportamento do consumidor. Neste episódio, Natuza Nery conversa com duas jornalistas do jornal Valor Econômico para explicar este fenômeno. Primeiro, ela fala com Stella Fontes, que detalha o caso da Braskem e o contexto crítico para a companhia no setor petroquímico. Depois, quem participa é Adriana Mattos, que aprofunda a análise sobre o que as empresas de varejo têm feito para tentar escapar à crise do setor.

Confira os destaques do Jornal da Manhã desta terça-feira (25): O presidente Luiz Inácio Lula da Silva e o presidente da Turquia, Recep Tayyip Erdogan, conversaram por telefone nesta segunda-feira (24) sobre caminhos diplomáticos e soluções pacíficas para as guerras na Ucrânia e no Oriente Médio. Os dois lamentaram a continuidade dos conflitos e defenderam a intensificação do diálogo internacional em busca da paz. Lula e Erdogan também celebraram a ratificação do Acordo de Cooperação em Indústria de Defesa pelos parlamentos dos dois países. Lula manifestou interesse em ampliar investimentos e parcerias no setor, e ficou acertado o envio de uma delegação brasileira à Turquia. Reportagem: André Anelli. O senador e candidato à Presidência Flávio Bolsonaro (PL-RJ) se reuniu com empresários durante visita à Fiesp, em São Paulo, nesta segunda-feira (24), e voltou a criticar o presidente Lula. Flávio afirmou que Lula “faz mais mal para o Brasil do que a pandemia” e disse que o governo utiliza o STF para governar, o que, segundo ele, demonstra “fadiga da nossa democracia”. O senador também declarou que o Congresso atual foi feito para um presidente como Bolsonaro. Caso seja eleito, prometeu escolher ministros “honestos e competentes” para seu governo. Reportagem: Beatriz Manfredini. O candidato à Presidência da República Ronaldo Caiado (PSD) reagiu com bom humor, nesta segunda-feira (24), ao flagra de seu vice, Gilberto Kassab, cochilando na plateia durante o primeiro debate presidencial de 2026, transmitido pela Band, em São Paulo, neste domingo (23). Em uma publicação no X, o ex-governador de Goiás citou a soneca de Kassab, também presidente do PSD, ao afirmar que, caso assuma a Presidência, o povo brasileiro vai “dormir tranquilo igual ao Kassab” durante o debate. Reportagem: Misael Mainetti. O presidente Luiz Inácio Lula da Silva (PT) voltou a defender o fim da escala 6x1 nesta segunda-feira (24). O chefe do Executivo disse, nas redes sociais, que a redução na carga horária de trabalho deve proporcionar mais tempo de lazer para a população. Lula afirmou que há pessoas que “jogam contra os interesses dos trabalhadores e trabalhadoras do Brasil”, mas que o governo está mobilizado para a aprovação do fim da escala 6x1, sem redução do salário. O presidente também disse que o povo trabalhador, que movimenta o país, merece mais tempo para o lazer, para cuidar da saúde e para acompanhar o crescimento dos filhos, destacando a importância do tempo para a família. Reportagem: André Anelli. A Polícia Federal (PF) vai ter acesso a elementos reunidos pela Polícia Civil de São Paulo durante busca e apreensão no Instituto Conhecer Brasil (ICB), que é ligado à produtora do filme sobre a trajetória do ex-presidente Jair Bolsonaro. Os dados encontrados pela Polícia Civil de São Paulo vão ser analisados no inquérito aberto pelo Supremo Tribunal Federal (STF) para apurar a suspeita de que emendas parlamentares podem ter abastecido a produção “Dark Horse”. O compartilhamento do material foi autorizado pelo ministro Flávio Dino no dia 21 de agosto. Lucas Mehero e Thulio Nassa comentaram. Reportagem: Marco Viana. Ricardo Salles, candidato ao Senado de São Paulo pelo partido Novo, participa da sabatina da Jovem Pan News e fala sobre diferentes temas relacionados à sua candidatura e à atuação no Senado. Salles comenta a relação com o PL e afirma que é “muito difícil chamar o PL de partido da direita”, fala sobre suas prioridades para um eventual mandato, com destaque para a defesa de São Paulo e o reequilíbrio entre os Poderes, critica a decisão da Justiça Eleitoral de São Paulo sobre os adesivos com “Fora Lula” em um ônibus de campanha, avalia a questão do meio ambiente após ter sido ministro no governo Bolsonaro, critica a visão de Marina Silva sobre o tema e também comenta o fim da escala 6x1, afirmando que votaria contra o projeto da forma como está. Essas e outras notícias você acompanha no Jornal da Manhã. Learn more about your ad choices. Visit megaphone.fm/adchoices

Confira no Morning Show desta terça-feira (25): A Polícia Federal (PF) vai ter acesso a elementos reunidos pela Polícia Civil de São Paulo durante busca e apreensão no Instituto Conhecer Brasil (ICB), que é ligado à produtora do filme sobre a trajetória do ex-presidente Jair Bolsonaro. Os dados encontrados pela Polícia Civil de São Paulo vão ser analisados no inquérito aberto pelo Supremo Tribunal Federal (STF) para apurar a suspeita de que emendas parlamentares enviadas pelo deputado federal Mário Frias (PL), produtor do longa, podem ter abastecido a produção “Dark Horse”. O compartilhamento do material foi autorizado pelo ministro Flávio Dino no dia 21 de agosto. O Discord pediu à Autoridade Nacional de Proteção de Dados (ANPD) que autorize a retomada das transmissões de vídeo suspensas no Brasil desde o último dia 17. Em recurso protocolado nesta segunda-feira, a empresa questiona o alcance e os fundamentos da medida e propõe, como alternativa, um plano com metas, prazos e retomada gradual das ferramentas. A Agência Nacional de Proteção de Dados (ANPD) multou em R$ 153,7 milhões a ByteDance, dona do TikTok, por falhas no tratamento de dados pessoais de crianças e adolescentes. A decisão foi publicada no Diário Oficial da União nesta terça-feira (25). A agência também determinou a eliminação dos dados coletados de forma irregular e estabeleceu que a empresa apresente um plano de conformidade para reforçar a proteção de menores na plataforma. Um levantamento de dados revelou que municípios do Paraná gastaram mais de R$ 1 bilhão em shows e eventos entre 2021 e o primeiro semestre de 2026. Apenas seis das 399 cidades do estado não registraram despesas deste tipo. Entre as atrações que mais receberam estão: a dupla sertaneja Fernando e Sorocaba, Guilherme e Benuto e Ana Castela. A Polícia Militar realizou, na manhã desta segunda-feira (24), uma operação em Parada de Lucas e Vigário Geral, na Zona Norte do Rio. Mais de 200 policiais participam da ação, realizada dois dias após uma operação no Complexo de Israel, na mesma região. Moradores informaram que houve um intenso tiroteio na chegada das equipes. Segundo a corporação, o objetivo é conter disputas territoriais entre grupos criminosos e combater roubos de veículos e cargas, exploração ilegal de serviços e outras atividades criminosas. Um avião monomotor pegou fogo na manhã desta terça-feira (25) enquanto voava sobre área de mata no entorno de Belo Horizonte (MG). O piloto da aeronave se ejetou e sobreviveu utilizando um para-quedas, sem ferimentos. O governo do presidente Donald Trump prepara uma nova ofensiva na política migratória dos Estados Unidos que pode atingir até 200 mil estrangeiros. O plano prevê o cancelamento de vistos de turismo e de negócios de pessoas que entraram no país como visitantes temporários e, posteriormente, solicitaram asilo. A medida abrange os vistos B1 e B2, utilizados principalmente para viagens de negócios e de turismo. O ministro da Fazenda, Dario Durigan, afirmou que o governo federal estima que o salário mínimo será de R$ 1.741 em 2027. O valor constará no Projeto de Lei Orçamentária Anual, que será encaminhado ao Congresso Nacional até o dia 31 deste mês. Com a medida, o senador e candidato à Presidência Flávio Bolsonaro (PL) acionou o TSE alegando que se trata de um ato eleitoral. Em entrevista ao Sofá da Discórdia, o presidente da Federação das Indústrias do Estado de São Paulo, Paulo Skaf, fala sobre a PEC que prevê o fim da escala 6X1. O líder patronal afirma que a medida “é uma PEC Boca de Urna” para favorecer a reeleição do presidente Lula (PT) e defende que a duração da jornada de trabalho deve ser negociada entre funcionários e empresários. Aline Borguetti, uma piloto brasileira, fala sobre sua trajetória na aviação civil, onde chegou a pilotar o maior avião do mundo, superando preconceitos em uma profissão predominantemente masculina. Essas e outras notícias você confere no Morning Show.

No 3 em 1 desta quarta-feira (19), o destaque foi o ministro do Supremo Tribunal Federal Gilmar Mendes que afirmou que o impeachment de ministros do Supremo não passa de uma “bandeira eleitoral” e afirmou que a medida será difícil de implementar. Reportagem: Janaína Camelo. A investigação contra o filho do atual Presidente Lula (PT), Fábio Luís Lula da Silva, o Lulinha, gera preocupação no Palácio do Planalto e abastece a campanha do senador Flávio Bolsonaro (PL), que deve usar o caso para atacar o adversário na corrida eleitoral. Reportagem: Bruno Pinheiro. Os aliados do atual Presidente Lula (PT) avaliam os possíveis impactos da entrada de Pablo Marçal (PRTB) na corrida pelo Palácio do Planalto. A avaliação é de que o desgaste será pequeno para para a campanha do petista, mas pode pulverizar os votos do campo da direita e prejudicar a campanha do senador Flávio Bolsonaro (PL). Reportagem: João Vitor Revedilho. Em sabatina no 3 em 1, o candidato ao governo de Minas Gerais, Flávio Roscoe (PL), apresentou suas propostas para destravar a economia mineira, para a educação e infraestrutura no estado. Durante a entrevista, ocandidato também comentou sobre sua atuação como presidente da Federação das Indústrias de Minas Gerais (FIEMG) e a articulação de sua campanha com a campanha presidencial de Flávio Bolsonaro (PL). O ex-dono do Banco Master, Daniel Vorcaro deve prestar depoimento na próxima quinta-feira (20) para esclarecer o ele com ex-servidores do Banco Central e também sobre a contratação de influenciadores para difamarem a autoridade monetária e favorecer o Banco Master. Reportagem: Beatriz Souza. Em entrevista à Jovem Pan o atual governador de São Paulo e candidato à reeleição pelo Republicanos Tarcísio de Freitas afirmou que rechaça o que não faz sentido no Bolsonarismo, mas defendeu a relação com o ex-presidente Jair Bolsonaro (PL). Tarcísio reforçou que o que une os dois é o alinhamento quanto aos valores. O candidato ao Palácio do Planalto Romeu Zema (NOVO) criticou o endividamento da família brasileira na gestão do governo do atual presidente Lula (PT). Zema apontou o encarecimento no preço dos alimentos e afirmou que o cidadão está cada vez “mais pobre”. O Supremo Tribunal Federal adia a análise que definirá as regras do mandato-tampão para o governo do Rio de Janeiro. Com a saída do ex-governador Cláudio Castro no início de 2026 e a tramitação do processo na Corte, a decisão segue incerta às vésperas das eleições. Tudo isso e muito mais você acompanha no 3 em 1. Learn more about your ad choices. Visit megaphone.fm/adchoices

¡QUE RUEDE LA PELOTA!

What if the best way to unlock durable, broad-spectrum immunity is to rethink the very vessels delivering our vaccines?While much of the industry focuses on refining existing delivery systems, Christopher Locher is charting a new course—one inspired by nature's own couriers. Imagine a future where oral vaccines and modular, on-demand manufacturing aren't just possibilities, but standard practice.Christopher Locher, CEO and Co-founder of Versatope Therapeutics, brings decades of experience in drug discovery from Vertex Pharmaceuticals, Opsona Therapeutics, and Maxigen. In this episode, he shares his journey from high school science classrooms to the helm of a company pioneering recombinant extracellular transport vesicles—nanovesicles that promise to transform vaccine delivery and immunomodulation.Topics discussed:How basic scientific curiosity and the inspiration from teachers sparked Christopher's career in biotechnology (03:39)The unmet needs in vaccine development for infectious and parasitic diseases, especially in regions below the equator (04:17)Engineering nanovesicles as immunomodulators and drug delivery vehicles, using microbial bioreactors for production (06:38)Co-producing proteins and vesicles in a single process, and the flexibility of the platform (08:28)Key benefits of Versatope's platform, such as cost efficiency, stability, and commercial scalability compared to mammalian exosomes (09:53)Prospects for multi-specific vaccines and the future direction for scalable bioprocessing (11:47)Adapting manufacturing processes and overcoming logistical challenges—from COVID-related shutdowns to supply chain bottlenecks (12:21)Strategies for navigating evolving regulatory requirements with agencies like the FDA, and experience with fast IND allowance (14:53)Analytical and characterization challenges of complex nanovesicle-based products versus simpler platforms like antibodies (17:30)The vision for decentralized or local vaccine manufacturing, especially in resource-limited settings (19:12)Smart insight: Christopher Locher highlighted that the FDA allowed their IND submission for a universal influenza vaccine in less than a month after review—and notably, with no hold clinical questions—when it was submitted just before the Christmas holidays and allowed on January 19th, 2025. This rapid regulatory turn-around was made possible by a strong regulatory team and collaborative CDMO efforts, showcasing how innovative platforms and well-prepared submissions can accelerate early-stage clinical development in biotech.If Christopher's vesicle platform has you thinking about building a novel modality on an unconventional host, these four episodes go deeper on alternative production systems, microbial scale-up, and the CMC and cost decisions that get a first-in-class biologic to patients.Episodes 217 - 218: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi OsawaEpisodes 239 - 240: Continuous Microbial Manufacturing: From Genetic Instability to 40-Day E. coli Processes with Juergen MairhoferEpisodes 231 - 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri KornmannEpisodes 267 - 268: Why Affordable Insulin Is a Money Problem, Not a Science Problem with Eric MoyalConnect with Christopher Locher:Website: www.versatope.com LinkedIn: www.linkedin.com/in/christopher-locher-biotechSupport the show

Send us Fan MailThe full week of Journal Club in one place. Monday, the PLaNT trial of prophylactic CPAP for late preterm infants born by cesarean, with senior author Dr. Edgardo Szyld. Tuesday, whether parental holding during therapeutic hypothermia changes feeding and length of stay. Wednesday, the Connection Study, the first live biotherapeutic product tested under an IND, and what it means for probiotics returning to the NICU. Thursday, a handheld light probe that reads bowel through the skin to catch NEC before the X-ray does. Friday, Dr. Dinushan Kaluarachchi on the respiratory severity score and what its trajectory tells us.----First-in-human pilot study of broadband optical spectroscopy (BOS) as noninvasive surveillance for necrotizing enterocolitis (NEC). Dodd AC, Lehane AJ, Lee A, Hurlock A, Su Y, Ilahi I, Lautz TB, Backman V, Goldstein SD.J Pediatr Surg. 2026 May;61(5):162978. doi: 10.1016/j.jpedsurg.2026.162978. Epub 2026 Feb 3.PMID: 41643767Association of parental holding during therapeutic hypothermia and NICU outcomes for infants with hypoxic-ischemic encephalopathy. Nguyen TT, Glass HC, Chan N, Taketa E, Pineda R, Cornet MC, Miller MJ.J Perinatol. 2026 Jun 22. doi: 10.1038/s41372-026-02753-3. Online ahead of print.PMID: 42332041Live biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study. Neu J, Del Moral T, Guthrie SO, Hudak ML, Indrio F, Kim JH, Kronström A, Martin CR, Modi N, Rastad J, Schnitzer TJ, Singh R, Strömberg S, Szajewska H, Thuresson M, Caplan M.Pediatr Res. 2026 Feb 20. doi: 10.1038/s41390-026-04826-7. Online ahead of print.PMID: 41721054Prophylactic CPAP at Cesarean Birth in Late-Preterm Newborns: A Multicenter RCT. Shah BA, DeShea L, Schmölzer GM, Josephsen JB, Fabres J, Wetzel EA, Rykovich H, Thomas A, Law B, Garrido C, Szyld E.Pediatrics. 2026 Aug 1;158(2):e2025070998. doi: 10.1542/peds.2025-070998.PMID: 42457181 Clinical Trial.Association Between Delivery Room Continuous Positive Airway Pressure and Neonatal Outcomes in Late Preterm and Term Infants: A Systematic Review and Meta-Analysis. Chin Y, Hill M, Sett A, Thomas N, Razak A.J Paediatr Child Health. 2026 Jul 28. doi: 10.1111/jpc.70516. Online ahead of print.PMID: 42517258 Review.Bronchopulmonary Dysplasia Definition Based on Respiratory Severity Score. Kaluarachchi DC, Peebles PJ, Lasarev MR, Guthrie SO, Laughon MM.Pediatr Pulmonol. 2026 Jul;61(7):e71750. doi: 10.1002/ppul.71750.PMID: 42478108 Free PMC article. No abstract available.Respiratory severity score patterns by birth gestational age among a cohort of extremely preterm infants. Peebles PJ, Lasarev MR, Guthrie SO, Laughon MM, Keller RL, Kaluarachchi DC.J Perinatol. 2026 Jun 29. doi: 10.1038/s41372-026-02778-8. Online ahead of print.PMID: 42374145 No abstract available.Respiratory severity score as a predictor for need for tracheostomy in infants with severe bronchopulmonary dysplasia. Kaluarachchi NM, Afah Annah S, Lasarev MR, Peebles PJ, Kaluarachchi DC.J Perinatol. 2026 Jun 25. doi: 10.1038/s41372-026-02720-y. Online ahead of print.PMID: 42350618 No abstract available.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Send us Fan MailProbiotics left US NICUs after the FDA reclassified them, and NEC rates went up. This week Ben reviews the Connection Study, a 2,158 infant phase 3 trial of IBP-9414, a live biotherapeutic product containing Limosilactobacillus reuteri, run under an IND with the regulatory rigor probiotics never had. Neither primary endpoint reached significance, but all cause mortality fell 27%, and surgically confirmed NEC favored treatment after 14 days of dosing. The discussion may be the real story, including a kappa of 0.36 between radiologists reading the same NEC films. Ben and Daphna talk through what a regulated probiotic would mean for the babies waiting now.----Live biotherapeutic product IBP-9414 (L. reuteri) in very low birth weight infants: the Connection Study. Neu J, Del Moral T, Guthrie SO, Hudak ML, Indrio F, Kim JH, Kronström A, Martin CR, Modi N, Rastad J, Schnitzer TJ, Singh R, Strömberg S, Szajewska H, Thuresson M, Caplan M.Pediatr Res. 2026 Feb 20. doi: 10.1038/s41390-026-04826-7. Online ahead of print.PMID: 41721054Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Danny has returned and we catch up on the latest Kawhi Leonard scandal and why extensions like those for Dillon Brooks and Naji Marshall are far more to blame for the league's financial predicament than the dreaded Aprons. Then, we finish out our assessment of the summer leaguers for HOU, IND, MIA, MIN, NOP, NYK, ORL, and POR. 0:00 Kawhi Leonard / Clippers: Daktronics side deal and salary-cap circumvention  9:36 Phoenix Suns: Dillon Brooks extension  16:27 Dallas Mavericks: Naji Marshall extension  20:43 Golden State Warriors: Draymond Green and Gary Payton II  23:10 Philadelphia 76ers: Kentavious Caldwell-Pope signing, Johni Broome trade/Jabari Walker roster decision  24:43 Draft/roster updates: Jack Kayil, Tyler Nickel, Dillon Mitchell  25:39 Houston Rockets: Jae'Sean Tate, J.D. Davison, Chip Engelland  28:13 Cleveland Cavaliers: Mario Hezonja  30:21 Other signings: Lonnie Walker IV, Quenton Jackson, Braden Smith  31:51 Jamir Watkins: Torn ACL  32:10 Washington Wizards: Anthony Davis extension talks  33:58 NBA: No Abu Dhabi preseason games 35:13 Houston Rockets: Bruce Thornton (35:13), Tristen Newton (41:34), Quadir Copeland (41:34)  41:52 Indiana Pacers: Braden Smith (41:57), Taelon Peter (46:22), Jalen Slawson (46:26)  49:58 Miami Heat: Ryan Conwell (49:58), Trevor Keels (52:07), Tre Donaldson (53:43), Myron Gardner (54:06), Jahmir Young (54:11)  54:30 Minnesota Timberwolves: Isaiah Evans (54:30), Joan Beringer (57:06), Trey Kaufman-Renn (1:00:03), Zyon Pullin (1:01:02), Rocco Zikarsky (1:02:51)  1:05:26 New Orleans Pelicans: Jaron Pierre Jr. (1:05:26)  1:06:31 New York Knicks: Tyler Nickel (1:06:56), Jack Kayil (1:09:24), Mohamed Diawara (1:12:25), Pacôme Dadiet (1:13:36)  1:16:54 Orlando Magic: Izaiyah Nelson (1:16:54), Jase Richardson (1:18:56), Noah Penda (1:22:03)  1:27:00 Portland Trail Blazers: Yang Hansen (1:27:00) Join Dunc'd On Prime! It's the only place to get every episode with Nate & Danny, plus every pod with John Hollinger & Nate as well!Subscribe on YouTube to get Dunc'd On Clutch Calls, Real Video Scouts, and more.Or, sign up for our FREE mailing list to get Dan Feldman's Daily Duncs with all the major topics around the league twice a week. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Merneptah vs the Libyans. In 1221 BCE, Egypt faced a crisis. Tribal coalitions from the west, and some "Peoples of the Sea" were marching on the Nile Valley. They came in their thousands, armed and ready to settle. Caught by surprise, King Merneptah and his warriors hastened to the defence... Support the show and get early releases, ad-free episodes, bonus video content, and pictures/videos of animals I meet in Egypt and travelling www.patreon.com/egyptpodcast Music by Bettina Joy de Guzman; Luke Chaos; and Keith Zizza. Bibliography Cline, E. H. (2021). 1177 B.C. The Year Civilization Collapsed (Revised edn). Princeton University Press. D'Amato, R., & Salimbeti, Andrea. (2015). Sea Peoples of the Bronze Age Mediterranean c.1400 BC–1000 BC. Osprey. Darnell, J. C., & Manassa, C. M. (2007). Tutankhamun's armies: Battle and conquest during ancient Egypt's late eighteenth dynasty. John Wiley & Sons. Davies, B. G. (1997). Egyptian Historical Inscriptions of the Nineteenth Dynasty. Paul Aströms förlag. Dean, R. (2017). Warfare & Weaponry in Dynastic Egypt. Pen & Sword. Finné, M., Woodbridge, J., Labuhn, I., & Roberts, N. (2019). Holocene hydro-climatic variability in the Mediterranean: A synthetic multi-proxy reconstruction. The Holocene, 29, 847--863. https://journals.sagepub.com/doi/abs/10.1177/0959683619826634 Heagren, B. (2010). The Art of War in Pharaonic Egypt [Unpublished PhD. Thesis, The University of Auckland]. https://www.researchgate.net/publication/49463150_The_art_of_war_in_pharaonic_Egypt_an_analysis_of_the_tactical_logistic_and_operational_capabilities_of_the_Egyptian_army Healy, M. (1992). New Kingdom Egypt. Osprey Publishing. Kaniewski, D., Campo, E. V., Guiot, J., Burel, S. L., Otto, T., & Baeteman, C. (2013). Environmental Roots of the Late Bronze Age Crisis. PLOS ONE, 8(8), e71004. https://doi.org/10.1371/journal.pone.0071004 Kaniewski, D., Marriner, N., Bretschneider, J., Jans, G., Morhange, C., Cheddadi, R., Otto, T., Luce, F., & Van Campo, E. (2019). 300-year drought frames Late Bronze Age to Early Iron Age transition in the Near East: New palaeoecological data from Cyprus and Syria. Regional Environmental Change, 19, 2287--2297. https://doi.org/10.1007/s10113-018-01460-w Kitchen, K. A. (1975). Ramesside Inscriptions Historical and Biographical (Vols. 1–8). Blackwell. https://archive.org/details/KennethA.KitchenRamessideInscriptionsVol1 Kitchen, K. A. (1993a). Ramesside Inscriptions Translated and Annotated: Notes and Comments (Vols. 1–2). Blackwell. Kitchen, K. A. (1993b). Ramesside Inscriptions Translated and Annotated: Translations (Vols. 1–7). Blackwell. Kopanias, K. (2017). Mercenaries or refugees? The evidence from the inscriptions of Merenptah on the “Sea Peoples.” Journal of Greek Archaeology, 2, 119--133. https://www.ancientportsantiques.com/wp-content/uploads/Documents/AUTHORS/SeaPeoples/SeaPeoples-Kopanias2017.pdf Manassa, C. (2003). The Great Karnak Inscription of Merneptah: Grand Strategy in the 13th Century BC. The Yale Egyptological Seminar. Pollastrini, A. M. (2024). Helmets and Body Armour in New Kingdom Egypt. Bloomsbury Academic. https://doi.org/10.5040/9781350323520 Sabbahy, L. (2013). Depictional Study of Chariot Use in New Kingdom Egypt. In A. Veldmeijer & S. Ikram (Eds.), Chasing Chariots: Proceedings of the First International Chariot Conference (Cairo 2012) (pp. 191--202). Sidestone Press. Shaw, G. J. (2017). War and Trade with the Pharaohs: An Archaeological Study of Ancient Egypt's Foreign Relations. Pen & Sword. Shaw, I. (2019). Ancient Egyptian Warfare. Casemate. Snape, S. (2003a). The Emergence of Libya on the Horizon of Egypt. In D. O'Connor & S. Quirke (Eds.), Mysterious Lands (pp. 93--106). UCL Press. Snape, S. (2003b). Zawiyet Umm el-Rakham and Egyptian Foreign Trade in the Thirteenth Century BC. Sea Routes: Interconnections in the Mediterranean 16th-6th c. BC. https://www.academia.edu/107251529/Snape_ZUR_and_Egyptian_Foreign_Trade_Zawiyet_Umm_el_Rakham_and_Egyptian_foreign_trade_in_the_thirteenth_century_BC_ Snape, S. (2023). What was Zawiyet Umm el-Rakham for? Early Ramesside Strategy in the Libyan West. In F. Hoffmann & M. R. Abbas (Eds.), Perspectives on the Ramesside Military System (pp. 143--155). Zaphon. Spalinger, A. J. (2004). Review: Manassa, Colleen 2003. The Great Karnak inscription of Merneptah: Grand strategy in the 13th century BC. Journal of Egyptian Archaeology, 90(reviews supplement), 45--47. https://www.jstor.org/stable/3822286 Zutterman, C. (2003). The bow in the Ancient Near East, a re-evaluation of archery from the late 2nd millennium to the end of the Achaemenid empire. IrAnt, 38, 119--165. Learn more about your ad choices. Visit megaphone.fm/adchoices