Podcasts about IND

Is chronic babesiosis finally getting the scientific attention it deserves?In this episode of Integrative Lyme Solutions, Dr. K sits down with Dr. Geoff Dow, CEO & President of Sixty Degrees Pharmaceuticals, to discuss a groundbreaking clinical trial targeting chronic babesiosis — a common and often overlooked Lyme co-infection. Originally developed for malaria prevention, the drug Tafenoquine (brand name Kodatef®) is now being studied for its potential to treat persistent Babesia infections and Lyme-related fatigue.They explore the science behind red blood cell parasites, how Babesia differs from malaria, why chronic babesiosis remains controversial, and what makes this new trial the first FDA-reviewed IND study focused on chronic disease. If you or a loved one struggle with Lyme-related fatigue, relapsing babesiosis, or limited treatment options, this conversation offers cautious optimism and a closer look at the future of targeted therapies.Key Takeaways:0:00 Introduction3:10 From Malaria Drug Development to Lyme Co-Infections6:45 How Babesia Infects Red Blood Cells and Causes Fatigue10:40 Why Chronic Babesiosis Is Still Controversial14:50 No FDA-Approved Drugs Specifically for Babesiosis18:30 New Clinical Trials for Chronic and Relapsing Babesiosis24:00 Measuring Fatigue as a Primary Endpoint in Chronic DiseaseResources Mentioned:Sixty Degrees Pharmaceuticals - https://www.sixtydegreespharma.comKodatef® (Tafenoquine) Information - Available via company website aboveMount Sinai (Clinical Trial Site) - https://www.mountsinai.orgYale Babesiosis Case Series (Referenced Study) - https://medicine.yale.eduMedical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. _______________________________The Karlfeldt Center offers the most cutting-edge and comprehensive Lyme therapies. To schedule a Free 15-Minute Discovery Call with a Lyme Literate Naturopathic Doctor at The Karlfeldt Center, call 208-338-8902 or email info@TheKarlfeldtCenter.comCheck out Dr. K's Ebook: Breaking Free From Lyme: A Comprehensive Guide to Healing and Recovery here: https://store.thekarlfeldtcenter.com/products/breaking-free-from-lymeUse the code LYMEPODCAST for a 100% off discount!

Sarah Elsie Baker is a Associate Professor and Head of Research at the Media Design School in Auckland, New Zealand. She is the author of Designing Gender: The Feminist Toolkit. In our conversation, Sarah reflects on why such a toolkit is necessary today and how it can be used to develop more critical, equitable, and reflective design practices.This episode is part of the list: Nueva Zelanda y diseño, Diseño feminista, Diseño con perspectiva de género, investigación en diseño and Government Design Finland, D&D in English. Even though the lists names are in Spanish, you might find episodes in English. In D&D in English all the episodes are in English. She recommends: Feminist is for everybody by bell hooksDesigning for Sex and Gender Equality by Isabel ProchnerFeminist Designer, On the personal and the political in design edited by Alison Place

Pirouette Pharma CEO Conor Cullinane returns to Inside Startup Investing to share the company's progress since its last Wefunder raise—spanning FDA engagement, IND planning, and major steps toward scalable manufacturing. Pirouette is building a disc-shaped, push-button delivery system for injectable medications—aiming to turn the “violent, error-prone” experience of legacy auto-injectors into something closer to the Staples Easy Button: push once, and the device handles the rest. Chris and Conor discuss why intimidation and usability are major barriers in today's injection landscape, how Pirouette is approaching OTC naloxone via a combination-product regulatory pathway, what a pharmacokinetic study looks like, and why Pirouette is investing in manufacturing capacity to support both commercialization and pharma partnerships.   Chapters  00:44 What Pirouette is building 03:42 Progress since last raise 06:26 FDA pathway explained 09:08 PK study + size/cost/timeline 13:07 Partnerships vs. standalone commercialization 16:15 Revenue timing + adoption expectations 20:12 Manufacturing scale plan 23:34 Founder “why” 26:07 Investor close

In this episode of the show, Jamie and Stu look back at Day 19 of the ICC Men's T20 World Cup, which saw the Black Caps of New Zealand take on the hosts of Sri Lanka. They also look ahead to a day with massive implications in Group 1 of the Super 8s, on which South Africa meets the West Indies and India & Zimbabwe look to bounce back after difficult losses. We start the show with a quick summary of Jamie's thoughts about England becoming the first side to qualify for the semi-finals, before diving deep into a big win for the Black Caps - and the nervy moments along the way. After being sent in to bat, Rachin Ravindra and Glenn Phillips were building a partnership, before a flurry of wickets from Chameera, Theekshana and Wellalage sent New Zealand spiralling from 75-2 to 84-6. Things were looking dicey for Black Caps fans, but after a slow start, Mitchell Santner and Cole McConchie - into the side in place of Jimmy Neesham - roared to the finish, taking 70 off the final 4 overs of the innings. Then, with ball in hand, Matt Henry gave New Zealand the perfect start, ripping through Pathum Nissanka, and he was backed up by 17 overs of spin that put the squeeze on Sri Lanka - highlighted by Rachin Ravindra's four-wicket haul. To round out the show, the boys look ahead to what shapes as a huge day for all the sides in Group 1. Will Keshav Maharaj be able to tame the batting power of the West Indies? And which of India or Zimbabwe will keep their World Cup dreams alive heading into the final Super 8 fixtures? We'll be back in your feed again tomorrow with the next instalment of our T20 World Cup coverage. Until then please take the time to give us a like, follow, share or subscribe on all our channels (@toporderpod on Twitter & Facebook, and @thetoporderpodcast on Instagram & YouTube) and a (5-Star!) review at your favourite podcast provider, or tell a friend to download. It really helps others find the show and is the best thing you can do to support us. You can also find all our written content, including our Hall of Fame series, at our website. You can also dip back into our guest episodes - including conversations with Mike Hesson, Shane Bond and Mike Hussey, current players such as Matt Henry, Sophie Devine and Ish Sodhi, coaches Gary Stead, Jeetan Patel and Luke Wright, as well as Barry Richards, Frankie Mackay, Bharat Sundaresan and many more fascinating people from all across the cricketing world. And if you'd like to reach out to us with feedback, questions or guest suggestions, get in touch at thetoporderpodcast@gmail.com. Thanks for listening. 0:00 Intro 1:00 England through to the semi finals 3:55 Black Caps v Sri Lanka 20:50 Day 19 Preview: SA v WI, Ind v Zim Learn more about your ad choices. Visit podcastchoices.com/adchoices

O presidente da Câmara, Hugo Motta (Republicanos-PB), confirmou que pretende votar a PEC que acaba com a jornada 6x1 até o mês de maio. No entanto, o otimismo político colide com os números alarmantes apresentados pela Confederação Nacional da Indústria (CNI).Segundo a entidade, a proposta, do jeito que está, pode elevar os custos das empresas em até R$ 178 bilhões anuais, gerando um impacto de 7% na folha de pagamentos e colocando em risco a competitividade do setor produtivo.Meio-Dia em Brasília traz as principais notícias e análises da política nacional direto   de Brasília.     Com apresentação de José Inácio Pilar e Wilson Lima, o programa aborda os temas mais quentes do cenário político e econômico do Brasil.     Com um olhar atento sobre política, notícias e economia, mantém o público bem informado.   Transmissão ao vivo de segunda a sexta-feira às 12h.   Apoie o jornalismo independente. Assine O Antagonista e Crusoé com 10% via Pix ou Google Pay:  https://assine.oantagonista.com.br/   Siga O Antagonista no X:  https://x.com/o_antagonista   Acompanhe O Antagonista no canal do WhatsApp. Boletins diários, conteúdos exclusivos em vídeo e muito mais.  https://whatsapp.com/channel/0029Va2SurQHLHQbI5yJN344  Leia mais em www.oantagonista.com.br | www.crusoe.com.br #Escala6x1 #HugoMotta #CNI #Indústria #Trabalho #EconomiaBrasil #Congresso #Populismo #Brasil #meiodiaembrasília #lula #politicabrasileira #politicabrasil

The chemicals industry remains locked into carbon-intensive, fossil-based manufacturing. Even engineered microbes like yeast or E. coli depend on expensive sugar feedstocks while generating significant waste. What if a photosynthetic organism could eliminate those constraints entirely—while commanding premium pricing as "ocean-derived"?On the Smart Biotech Scientist Podcast, Tim Corcoran, CEO and Co-Founder of Deep Blue Biotech, reveals how a recently discovered fast-growing marine cyanobacteria strain is unlocking carbon-neutral chemical production at costs below conventional fermentation. With his background spanning economics, operations, and innovation commercialization, Tim challenges conventional assumptions about synthetic biology scale-up, market entry strategy, and what actually separates successful biotechs from valley-of-death casualties.Key topics discussed:Tim Corcoran's background in commercial roles, his pivot to biotech, and the founding story of Deep Blue Biotech (03:41)Overview of cyanobacteria biology: photosynthetic efficiency and its legacy in Earth's atmosphere (07:22)What makes the discovered ocean-based strain unique—and its advantages in robustness, growth rate, and use in personal care (08:27)Commercial challenges and scientific limitations that have made cyanobacteria difficult to industrialize—plus recent breakthroughs (9:38)Comparison with legacy hosts such as E. coli, yeast, microalgae: efficiency, feedstocks, genetic tractability, and downstream processing(11:02)The significance of direct secretion for lowering production costs and reducing CO₂ footprint (14:38)Scale-up strategies with photobioreactors: modularity, light and CO₂ management, and future tech improvements (15:17)Commercial strategy: starting with high-value personal care hyaluronic acid, regulatory considerations, and the rationale for this approach (17:17)The importance of aligning scientific innovation with market needs and early customer discovery (20:31)Long-term vision: potential for cyanobacteria in sustainable production of commodity chemicals like biofuels and the impact on global emissions (22:04)Strategic insight:Deep Blue Biotech's "premium-first commercialization" mirrors Tesla's playbook: start with high-margin applications ($2,000/kg hyaluronic acid for personal care) to generate immediate revenue and prove the platform. These early profits fund continuous strain engineering and process optimization, progressively driving down cost-of-goods while improving volumetric productivity. Only after establishing economic viability at premium pricing does the company target large-volume commodity markets—sustainable fuels, industrial chemicals—where success requires demonstration of competitive economics at industrial scale.Discover how this photosynthetic organisms could decarbonize entire chemical supply chains while improving manufacturing economics. Part 2 reveals the strategic decisions separating synthetic biology winners from failures, photobioreactor infrastructure challenges, and why licensing beats building multiple facilities.If you're interested in other unconventional biological platforms reshaping biomanufacturing, don't miss:Episode 163-164: How Moss Enables Production of Unproducible Protein Therapeutics with Andreas SchaafEpisodes 141-142: How Microalgae Cuts Antibody Costs by 70% and Redefines Biomanufacturing with Muriel BardorConnOne bad CDMO decision can cost you two years and your Series A. If you're navigating tech transfer, CDMO selection, or IND prep, let's talk before it gets expensive. Two slots open this month.Support the show

Confira os destaques do Jornal da Manhã desta terça-feira (24): O presidente da Ucrânia, Volodymyr Zelensky, afirmou nesta segunda-feira (23) que o líder da Rússia, Vladimir Putin, já teria iniciado uma “Terceira Guerra Mundial”. Segundo Zelensky, há diferentes interpretações sobre o tema, mas a ofensiva russa representaria um conflito de escala global, com a principal questão sendo até onde Moscou pretende avançar e como impedir essa expansão. A depoente Ingrid Pikinskeni Morais Santos não retornou à sessão da CPMI do INSS após um intervalo na oitiva realizada no Senado Federal. Segundo nota da presidência da comissão, ela apresentou um mal-estar e foi avaliada pela equipe médica da Casa, o que levou à suspensão dos trabalhos. Ingrid é esposa e sócia de Cícero Marcelino de Souza Santos, apontado como operador e assessor do presidente da Confederação Nacional dos Agricultores Familiares, uma das entidades que estão sob investigação da CPMI. O governador de São Paulo, Tarcísio de Freitas (Republicanos), afirmou nesta segunda-feira (23) que o Instituto Butantan “forneceu esperança” ao Brasil durante a pandemia da Covid-19. A declaração foi feita durante cerimônia em comemoração aos 125 anos da instituição, realizada na Zona Oeste da capital paulista, na qual o governador destacou os avanços científicos e o papel estratégico do Butantan na saúde pública. O presidente em exercício e ministro do Desenvolvimento, Indústria, Comércio e Serviços, Geraldo Alckmin, afirmou nesta segunda-feira (23) que o Brasil foi o país mais beneficiado do mundo com as novas tarifas anunciadas pelo presidente dos Estados Unidos, Donald Trump. A declaração foi feita em São Paulo, durante evento na Fiesp, e se refere à tarifa global de 15% sobre produtos importados pelos EUA, que entra em vigor nesta terça-feira (24). O presidente da Ucrânia, Volodymyr Zelensky, fez um apelo direto ao ex-presidente dos Estados Unidos, Donald Trump, ao pedir que o líder norte-americano “permaneça ao nosso lado”. A declaração foi dada em entrevista à CNN Internacional, nesta segunda-feira (23), véspera do quarto aniversário da guerra no Leste Europeu. O Ministério da Justiça e Segurança Pública e a Interpol anunciaram nesta segunda-feira (23) a criação de uma força integrada sul-americana para combater organizações criminosas, com foco especial no tráfico internacional de drogas. O grupo atuará exclusivamente na América do Sul e será coordenado e financiado pelo Brasil, por meio da Polícia Federal e do próprio ministério. O relator da CPMI do INSS, o deputado Alfredo Gaspar (União Brasil-AL), afirmou que o banqueiro Daniel Vorcaro e representantes de bancos investigados devem prestar contas diretamente à comissão, em Brasília, sem qualquer tratamento diferenciado. Gaspar criticou a possibilidade de depoimentos fora da CPMI e disse ser contrário ao que chamou de “depoimento marmita”, reforçando que não pode haver distinção entre investigados VIPs e não VIPs. O ministro Gilmar Mendes, do Supremo Tribunal Federal, decidiu nesta segunda-feira (23) que verbas indenizatórias, conhecidas como “penduricalhos”, só podem ser pagas a membros do Poder Judiciário e do Ministério Público quando houver previsão expressa em lei aprovada pelo Congresso Nacional. A decisão também restringe a atuação do Conselho Nacional de Justiça e do Conselho Nacional do Ministério Público, que passam a poder apenas regulamentar benefícios já previstos em lei, com base de cálculo, percentual e teto claramente definidos. Essas e outras notícias você acompanha no Jornal da Manhã. Learn more about your ad choices. Visit megaphone.fm/adchoices

Stāsta Latvijas Nacionālā mākslas muzeja Kolekciju glabātāja Aija Zandersone; pārraides producente – Inta Zēgnere Pirmā pasaules kara gados Jāzepa Grosvalda bezrūpīgajai Eiropas pleiboja dzīvei tika pielikts punkts. Dažādie likteņa līkloči Grosvaldu aizdeva uz latviešu strēlnieku rindām, vēlāk – galveno artilērijas pārvaldi Petrogradā, kopējo kara gadu noskaņojumu rezumējot ar šo rindu: “Apnikusi šī dzīve, apnicis karš, apnikusi revolūcija – vai liktenis nebūtu tik laipns drusku palīdzēt?” Un liktenis palīdzēja. Pateicoties nejauši satiktam dienesta biedram, kurš devās uz apmācībām Francijā, un Jāzepa joka pēc izteiktajai vēlmei doties līdzi, viņam pavērās iespēja atkal nokļūt Eiropā. Francijā Grosvalds klausījās priekšlasījumus par tolaik karā lietotajām indīgajām gāzēm, piedalījās izmēģinājumos un ārpus tiem atkal centās pietuvoties savai pirmskara dzīvei. Kad mācības bija noslēgušās, viņš kopā ar biedriem nokļuva Londonā un bija skaidrs, ka atgriešanās revolūcijas plosītajā Krievijā nebija vēlama: “Mans nodoms te palikt un te kaut kur iestāties, esmu gatavs uz visu.” Grosvalds centās iestāties diplomātiskajā dienestā – dibināja kontaktus ar pareizajiem cilvēkiem, kādam izlūkdienesta darbiniekam tulkoja rakstus no avīzes “Līdums” par latviešu stāvokli un vēlmēm, taču bez skaidriem panākumiem. Angļu pavēlniecība Londonā palikušajiem krievu armijas virsniekiem lika izšķirties un kaut ko darīt, kā vienu no iespējām piedāvājot iestāties īpašā krievu kareivju nodaļā Mezopotāmijas frontē. Nedaudz pasvārstījies, bet labāku izeju nerazdams, Jāzeps Grosvalds pieņēma šo likteņa pavērsienu. Jau paredzot jauno iespaidu nozīmi, viņš iepirka krāsas un skiču grāmatiņas un pat ņēma bandžo stundas, kas palīdzētu tikt galā ar paredzamo garlaicību garajā kuģa ceļā. Saglabājis ticību “kā vienmēr, savai laimei, kas līdz šim vienmēr attaisnojusi visus lēmumus un soļus,” mākslinieks devās ceļā no Londonas uz Šerbūru Francijā, tad ar vilcienu cauri Francijas un Itālijas teritorijai līdz Taranto pilsētai Itālijas dienvidos, no kurienes ar tvaikoni pārcēlās uz Aleksandriju Ēģiptē. Tālākais ceļš veda uz Suecu un atkal tvaikonī pa Sarkano jūru, Indijas okeānu un Persijas līci. “Zīmēju visu laiku. Tu vari iedomāties, kādas jaunas senzācijas,” tā jau pēc piedzīvotā rakstīja Jāzeps. Ir saglabājušās vairākas skiču burtnīcas un daudzi akvareļgleznojumi, kurus skatot dažkārt aizmirstas, ka šis nav bijis viss labi situēta mākslinieka eksotisks atpūtas brauciens, bet gan karagājiens Britu impērijas armijas sastāvā ar noteiktu fizisku un arī emocionālu nastu. Neiedziļinoties militārās vēstures lappusēs un skatienu vēršot Grosvalda Austrumu realitātes vērojumā un atstātajās piezīmēs, līdz ar Grosvalda ceļu cauri Persijai pavērās arī jauna nodaļa Grosvalda daiļradē. Piedzīvojuma rezultātā radās Latvijas mākslas vēsturē unikālās piezīmes “Persijas ainas”, kurās atklājas latviešu mākslinieka skatījums uz vietējo tautu un kopienu sadzīvi, tradīcijām un pieredzēto skarbo realitāti. Un vienlaikus tie parāda neslēptu interesi un Grosvalda vērotāja aci. “Persijas ainas” iesākas, kad armijas korpuss bija nonācis mūsdienu Irākas un Irānas pierobežā, un noslēdzas Anzalī ostā, no kurienes tālākais ceļš veda uz Baku, kas bija šīs militārās misijas mērķis. Tās aptver gandrīz 900 km garu ceļu, kura lielākā daļa ieta kājām un ar kamieļu un ēzeļu palīdzību “šai zemē, kur dzelzceļa nepazīst.” No dzīvniekiem tieši kamieļi piesaistīja īpašu autora uzmanību: “Kādu dzīvnieka karikatūru gan daba izgudrojusi, radot šo ķēmīgo kupraino milzi ar strausa kaklu un pērtiķa galvu! Bet ar visu to acis, grotesko lūpu izteiksme un lepni atmestā galva bezkaunīgi atgādina cilvēku.” Asā vērotāja acs pievērsās gan nepierastajām ainavām (“Peizāži – sarkanbrūni kalni ar drupām un zilas grēdas fonā, sakumā atgādina Spāniju, bet tad pavisam savādi, groteski un persiski, ļoti spici jeb ļoti apaļi kalni bez veģetācijas, tikai ar melniem punktiem, maziem viršu krūmiņiem.”) gan Austrumu pilsētu centrālajam elementam – tirgum (“Katras orienta pilsētas centrs ir bazārs, plašu, velvjainu gaiteņu labirints, kas dod patvērumu no saules un kur no abām pusēm smaiļarku nišās sarindotas pārdotavas un amatnieku darbnīcas. Dienas laikā šī tirgotāju pilsēta uzsūc visus iedzīvotājus – tur satiekas, apmeklē cits citu, kārto darījumus.”) Pierakstītos iespaidus papildina tik pat izteiksmīgi zīmējumi, kuros atklājas pilsētu ikdiena, vietējie iedzīvotāji, tējnīcas, ubagi un bada cietēji, tirgus interjeri un kalnainā ainava. Tās ir kopumā reālistiskas ainas, tomēr ne bez zināmas romantizētas eksotikas. Vēlāk, jau atgriezies Eiropā, Grosvalds apkopoja Austrumu cikla zīmējumus un, ņemot talkā atmiņas, uzgleznoja trīs eļļas gleznas ar Austrumu motīviem. 1920. gada 28. janvārī Parīzē, Grand Palais zālē tika atklāta Neatkarīgo mākslinieku biedrības (Salon des Indépendant) izstāde, kur skatītāji varēja iepazīties ar šīm gleznām. Diemžēl, Jāzeps Grosvalds izstādes atklāšanā nepiedalījās. Vien dažas dienas vēlāk, 1920. gada 1. februārī spāņu gripas otrajā vilnī aprāvās jaunā mākslinieka dzīve.

NESTA EDIÇÃO. Lula e Modi fecham parceria em mineração, com foco em terras raras. Redata será um dos temas tratados por Lula com Trump. Indústria química é desafio para emissões na China. Grupo J&F entra com pedido para autoimportar gás natural da Argentina. ANP interdita unidade da Vibra Energia após explosão. Mudança no ICMS dos combustíveis em 2022 terá efeito duradouro na receita de estados. ***Locução gerada por IA

In the Best of Mully & Haugh this week, David Haugh and Ruthie Polinsky reacted to the Bears taking a step toward building a new stadium in Hammond, Ind.; Haugh and Polinsky debated whether the Bears are more likely to have the best offense in the NFL in 2026 or trade for Raiders star pass rusher Maxx Crosby this offseason; and sports business expert Marc Ganis joined the show to discuss the latest developments in the Bears' stadium saga.

Pour télécharger mes notes de lecture : https://robintyonnel.com/notes-de-lecture-feel-good-productivity/

Confira os destaques do Jornal da Manhã desta sexta-feira (20): O governador de São Paulo, Tarcísio de Freitas, comemorou publicamente o rebaixamento da escola de samba Acadêmicos de Niterói, que homenageou o presidente Luiz Inácio Lula da Silva durante o desfile do Grupo Especial do Carnaval do Rio de Janeiro. Em entrevista coletiva nesta quinta-feira (19), Tarcísio afirmou estar “muito feliz” com o resultado, classificando o rebaixamento como “muito bem-vindo”. Está em análise na Câmara dos Deputados o Projeto de Lei 7015/25, que torna obrigatória a divulgação semanal da agenda deliberativa do Plenário da Câmara por emissoras de rádio e televisão. A proposta determina a veiculação de mensagem institucional de utilidade pública com informações sobre datas, horários e temas das sessões de votação. O presidente em exercício e ministro da Indústria, Geraldo Alckmin, afirmou nesta quinta-feira (19) que os vinhos brasileiros contarão com mecanismos de proteção no acordo entre o Mercosul e a União Europeia. Segundo Alckmin, o tratado já prevê um capítulo específico sobre salvaguardas, que será regulamentado por decreto pelo presidente Luiz Inácio Lula da Silva. A declaração foi feita durante a Festa do Vinho, no Rio Grande do Sul, e busca tranquilizar produtores nacionais diante da maior concorrência com rótulos europeus. O presidente dos Estados Unidos, Donald Trump, afirmou que determinou ao Secretário da Guerra e a outros departamentos e agências federais a divulgação de documentos oficiais sobre vida alienígena, fenômenos aéreos não identificados (UAPs) e objetos voadores não identificados (OVNIs). A ordem foi anunciada após repercussão de uma entrevista do ex-presidente Barack Obama ao podcast de Brian Tyler Cohen, na qual Obama negou que eles estejam escondidos na chamada Área 51. O presidente da Unafisco Nacional, Kléber Cabral, foi intimado a depor à Polícia Federal nesta sexta-feira (20). A oitiva foi determinada por ordem do ministro Alexandre de Moraes, do Supremo Tribunal Federal. O projeto Antifacção continuará sob a relatoria do deputado Guilherme Derrite, após decisão do presidente da Câmara, Hugo Motta. A manutenção ocorre em meio a discussões políticas sobre a condução e os ajustes no texto. A Prefeitura de São Paulo e o governo de São Paulo enviaram um ofício conjunto ao governo federal com duras críticas à Enel, distribuidora de energia que atua na capital e na região metropolitana. O documento aponta falhas recorrentes no fornecimento e sinaliza um rompimento institucional com a concessionária. A Agência Nacional de Energia Elétrica (Aneel) já respondeu com um relatório técnico sobre o pedido de caducidade do contrato, e a distribuidora tem prazo até o dia 26 de fevereiro para apresentar suas considerações antes de uma decisão definitiva. O Plenário do Supremo Tribunal Federal (STF) anulou, por unanimidade, uma lei complementar municipal que instituía o “Programa Escola sem Partido” em Santa Cruz de Monte Castelo, no interior do Paraná. Os ministros seguiram o entendimento do Ministério Público Federal (MPF) de que a norma invade a competência privativa da União para legislar sobre diretrizes gerais da educação e representa uma forma de cerceamento da atividade docente. O julgamento ocorreu nesta quinta-feira (19). O primeiro-ministro do Reino Unido, Keir Starmer, recusou um pedido do presidente dos Estados Unidos, Donald Trump, para o uso de instalações militares britânicas em eventuais operações contra o Irã. Segundo o governo britânico, a autorização violaria o direito internacional. Essas e outras notícias você acompanha no Jornal da Manhã. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jornal da ONU, com Felipe de Carvalho:*Mulheres ucranianas chegam ao limite após quatro anos de guerra *Relator da ONU denuncia trabalho forçado em centros de fraude online *Indústria criativa pode perder até 24% das receitas globais por causa da IA*ONU pede renovação de compromissos com justiça social

Der er god fart på de danske boligpriser og bolighandler, om end de ekstrem prisstigninger er et mere isoleret storbyfænomen. Det kommer diskussionen om at omlægge boligskatter næppe til at ændre ved. Ind til videre har boligpriserne ikke rigtig påvirket resten af økonomien, men det kan ændre sig her i 2026.

O grupo CEPCOM (Crítica da Economia Política da Comunicação) da Universidade Federal de Alagoas (Ufal) inicia um novo formato do ciclo de leituras, voltado à formação da base da Economia Política da Comunicação com mestrandas e mestrandos.Este episódio discute o artigo "Indústria Cultural e capitalismo tardio: Origens da Economia Política da Comunicação no Brasil em Mercado Brasileiro de Televisão" (Bastos, 2020). O texto foi apresentado por Lucas Souza (mestrando em Comunicação da UEL); com comentários de Vitória Rocha (mestranda em Comunicação da Ufal), Anderson Santos (professor dos mestrados em Comunicação da UEL e da Ufal) e Júlio Arantes (professor da Ufal).ReferênciaBASTOS, M. D. Indústria Cultural e capitalismo tardio: Origens da Economia Política da Comunicação no Brasil em Mercado Brasileiro de Televisão. Chasqui, Quito, n. 142, p. 187-202, dez. 2019/mar. 2020. DOI: https://doi.org/10.16921/chasqui.v1i142.4121. Disponível em: https://revistachasqui.org/index.php/chasqui/article/view/4121. Acesso em: 20 fev. 2026.Referências citadasBOLAÑO, C. (Coord.). Economía política de la comunicación y la cultura en América Latina (1970 y 1980). Buenos Aires: CLACSO, 2022. Disponível em: https://biblioteca-repositorio.clacso.edu.ar/bitstream/CLACSO/170046/1/Economia-politica-comunicacion.pdf. Acesso em: 20 fev. 2026.REVISTA EPTIC. v. 27 n. 3 (2025): Perspectivas críticas de abordagem da Publicidade - A embalagem do Sistema 40 anos depois. Disponível em: https://periodicos.ufs.br/eptic/issue/view/1434. Acesso em: 20 fev. 2026.

U.S. Air Force Master Sgt. Natalie Sonner, sustainment flight chief, and Tech. Sgt. Christopher Wilkinson, fitness non-commissioned officer, both assigned to the 122nd Fighter Wing, Fort Wayne, Ind., discuss duties, responsibilities and training of the force support squadron, January 9, 2026. Sonner and Wilkinson share stories and experiences from their service in the U.S. Air Force. (U.S. Air National Guard audio by Tech. Sgt. Kathleen LaCorte)

In this episode, Peg Crowley-Nowick speaks with Joseph Elassal, MD, MBA, Chief Medical Officer of Ankyra Therapeutics, about the strategic, operational, and financial realities of leading clinical development from pre-IND through proof of concept and toward commercialization.   Drawing on experience across large pharma, biotech partnerships, and early-phase oncology, Joe shares a practical roadmap for new and aspiring CMOs. They discuss how to prioritize essential capabilities, including clinical operations, regulatory strategy, biostatistics, and pharmacovigilance, while determining the right time to introduce Medical Affairs. The conversation outlines how to scale teams at critical inflection points such as IND clearance, Phase 2 proof of concept, and advancement into Phase 3.   The episode also examines investor and board expectations, CRO selection, capital efficiency, cash runway management, and the performance metrics CMOs are ultimately judged on—from disciplined milestone execution to generating meaningful clinical data. This episode offers actionable insight for biotech founders, clinical development leaders, medical affairs professionals, and emerging CMOs navigating the path from early development to launch.

O projeto de lei que prevê a redução da jornada de trabalho tem gerado preocupação no setor produtivo de Santa Catarina. O tema foi debatido nesta semana pelo Conselho das Federações Empresariais de Santa Catarina (COFEM), que reúne as principais entidades representativas da economia do estado. Para as lideranças empresariais, por se tratar de uma mudança estrutural com impactos profundos na economia, no emprego e na competitividade do país, a proposta exige uma análise técnica detalhada, baseada em dados e estudos consistentes. Durante o encontro, representantes das entidades alertaram para o risco de o debate ser influenciado por interesses eleitorais, especialmente por ocorrer em ano de eleição, o que pode comprometer a busca por soluções sustentáveis e equilibradas. Santa Catarina registra uma das menores taxas de desocupação do país, com índice de 2,3% no terceiro trimestre de 2025, e já enfrenta dificuldades para preencher vagas em diversos setores. Dados setoriais indicam retração na oferta de profissionais, como no transporte rodoviário, que apresentou redução significativa no número de caminhoneiros na última década. O setor produtivo também aponta possíveis impactos econômicos da medida. Estudos da Confederação Nacional da Indústria (CNI) indicam que a migração para uma jornada semanal de 36 horas pode elevar em cerca de R$ 178 bilhões por ano os custos diretos da indústria. As entidades reforçam que não são contrárias ao debate sobre a jornada de trabalho, mas defendem que a discussão seja conduzida com profundidade técnica, diálogo e responsabilidade, distante de disputas eleitorais. O vice-presidente da Regional Sul da Federação das Indústrias de Santa Catarina (Fiesc), Edilson Zanatta, comentou o tema em entrevista ao programa Cruz de Malta Notícias, nesta quinta-feira (19). Ouça a entrevista completa:

Passando a Limpo: No Passando a Limpo desta quarta-feira (18), Igor Maciel e a bancada do programa conversam com o Vice-presidente da Associação Brasileira da Indústria de Hotéis de Pernambuco (ABIH-PE), Eduardo Cavalcanti, sobre a ocupação hoteleira em Pernambuco com o Carnaval 2026.

Au micro d'Audrey Déléris, c'est aujourd'hui Malak Tazi, Secrétaire Générale du Club Med, qui revient sur son parcours et ses choix de carrière.Née au Maroc, où elle effectue ses études secondaires, Malak arrive en France pour étudier le droit. Celle que ses proches a toujours appelée « l'avocate » a débuté sa carrière comme avocate en M&A et corporate finance chez UGGC, puis chez Brandford Griffith, avec un détachement à la Caisse des Dépôts, avant de rejoindre Olswang.En 2013, elle quitte le cabinet pour intégrer AREVA comme VP General Counsel Governance, Corporate, Securities and Finance. Elle poursuit ensuite au sein du groupe Korian, où elle devient Group General Counsel, Secrétaire générale et Board Secretary.Dans cet épisode, elle revient sur son parcours international, le passage du cabinet à l'entreprise et l'évolution stratégique du rôle de directeur juridique.Elle nous parle de l'intérêt d'être juriste et de son implication sur les sujets opérationnels. Malak nous a aussi parlé du marketing de la direction juridique, du Professeur Didier Martin, Claude Imauven, Président d'Orano, Christian Chautard, ex-Président de Korian. Indépendance, énergie positive et qualité sont les leitmotivs de Malak Tazi ! Bonne écoute !  Voici les références de ce podcast :  Le profil de Malak TAZILe podcast VEDD avec Olivier CATHERINE (SONEPAR) Ecoutez l'intégralité des épisodes de Voix d'entrepreneurs du droit by Fed Legal : https://podcast.ausha.co/voix-d-entrepreneurs-du-droit-by-fed-legal.....FED Group donne aussi de la voix :- Aux soignants, dans notre podcast "Voix des soignants"- Aux recruteurs, dans notre podcast "Voix de recruteurs".....Qui sommes-nous ?Fed Legal, est un cabinet de recrutement et de chasse de têtes, dans le secteur juridique et fiscal. Notre équipe d'experts accompagnent les professionnels du droit en leur proposant des opportunités de carrière. Nos domaines de compétences : cabinets d'avocats, directions juridiques, notariat, directions fiscales, conseils en propriété industrielle / ingénieurs brevets. Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Olivier Oddou et Rémy Bertholon reviennent tout juste du Paris Radio Show où ils ont interviewé des grands noms de la radio en France. Ils ont reçu entre autres Romain Laleix de l'Arcom, Jean-Éric Valli des Indés Radios, Bertrand Spinelli de Skyrock Public, Kevin Moignoux du SIRTI, Sylvain Delfau du SNRL et de l'association Les Locales, Régis Verbiguié de Radio Player France, Charles-Emmanuel Bon d'Ensemble pour le DAB+, et enfin Tristan Jurgenssen et Mourad Moqaddem de Fun Radio et RTL2.Ces prochaines semaines, vous allez retrouver ces interviews une à une au rythme d'un épisode toutes les dizaines de jours, et on commence dans l'épisode d'aujourd'hui avec Romain Laleix de l'Arcom.Livre blanc, diversité du paysage radio, difficultés de financement, déploiement du DAB+, équipement des voitures, règles de concentration, quotas de chansons françaises, élections : tous les sujets ont été élaborés avec Romain Laleix, Président du groupe Radio et Audio numérique à l'Arcom.Et avant cela, on fera comme à chaque épisode un tour de l'actu radio.....Animation / réalisation : Olivier OddouIntervenant : Rémy BertholonInvité : Romain Laleix - Membre de l'Arcom et Président du groupe Radio et Audio numériqueCrédits musicaux : Rob - It's a blast (BO du film 'Radiostars'), jingles produits par Pure Jingles [https://purejingles.com/]Voix off : Estelle Hubert [https://estellehubert.com]ContactPar mail : contact@vocast.fr [https://www.vocast.fr/contact.html]X : @DesOndesVocast [https://x.com/DesOndesVocast]

Olivier Oddou et Rémy Bertholon reviennent tout juste du Paris Radio Show où ils ont interviewé des grands noms de la radio en France. Ils ont reçu entre autres Romain Laleix de l'Arcom, Jean-Éric Valli des Indés Radios, Bertrand Spinelli de Skyrock Public, Kevin Moignoux du SIRTI, Sylvain Delfau du SNRL et de l'association Les Locales, Régis Verbiguié de Radio Player France, Charles-Emmanuel Bon d'Ensemble pour le DAB+, et enfin Tristan Jurgenssen et Mourad Moqaddem de Fun Radio et RTL2.Ces prochaines semaines, vous allez retrouver ces interviews une à une au rythme d'un épisode toutes les dizaines de jours, et on commence dans l'épisode d'aujourd'hui avec Romain Laleix de l'Arcom.Livre blanc, diversité du paysage radio, difficultés de financement, déploiement du DAB+, équipement des voitures, règles de concentration, quotas de chansons françaises, élections : tous les sujets ont été élaborés avec Romain Laleix, Président du groupe Radio et Audio numérique à l'Arcom.Et avant cela, on fera comme à chaque épisode un tour de l'actu radio.Animation / réalisation : Olivier OddouIntervenant : Rémy BertholonInvité : Romain Laleix - Membre de l'Arcom et Président du groupe Radio et Audio numériqueCrédits musicaux : Rob - It's a blast (BO du film 'Radiostars'), jingles produits par Pure JinglesVoix off : Estelle HubertContactPar mail : contact@vocast.frX : @DesOndesVocastHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Bon dia! Desperteu-vos que les campanes de Sant Joan fa estona que toquen i aquest és l'Infopòdcast de Valls d'aquest dimecres 18 de febrer. Comencem el nostre capítol informatiu explicant-vos que La Cambra de Comerç i Indústria de Valls i Vallsgenera presenten la tercera edició de la Fira de l'Ocupació de Valls i l'Alt Camp. L'esdeveniment tindrà lloc el dijous 16 d'abril, en horari de 9h a 13.30h i de 15h a 18.30h, al Pavelló Xavi Tondo i Volpini. Es tracta d'un espai que ofereix les sinèrgies necessàries entre el teixit empresarial en cerca de talent i les persones que busquen oportunitats laborals. A més de l'espai d'estands empresarials, l'esdeveniment comptarà amb un ampli dispositiu d'orientació i assessorament.Les empreses interessades poden inscriure's a la Fira a través de la pàgina web de la Cambra de Comerç de Valls o de Vallsgenera, fins al 10 d'abril. Anem a l'atenció comunitària. El proper dijous 19 de febrer es posarà en marxa la vuitena edició de l'Escola de Persones Cuidadores. Es tracta d'un espai de formació i suport adreçat a familiars i professionals que tenen cura de persones en situació de dependència. El programa inclou 12 sessions, que aniran a càrrec de diversos professionals de l'àmbit de la salut, social i esportiu, i tindran lloc els dijous de 15.15h a 17.15 h al Casal Cívic Municipal de Ca Xapes. L'Escola de Persones Cuidadores oferirà tallers pràctics, sessions informatives i espais d'intercanvi d'experiències per millorar el benestar físic i emocional de les persones cuidadores, així com eines per afrontar el dia a dia amb més seguretat i confiança.Seguim amb Carnaval. Aquest Dimecres de Cendra s'acaba al Carnaval amb el seguici fèretre de Sa Majestat el Rei Carnestoltes i la baixada de la Geganta Quaresma. La comitiva arrencarà, a les 19h, des de davant del local social de la Unió Anelles de la Flama, amb la cercavila de la Vella Quaresma. En el seu pas per la placeta de l'1 d'octubre, es recolliran les despulles del Carnestoltes, el qual serà cremat a la plaça del Blat. L'acte mantindrà la col·laboració de la Societat de Sant Antoni. Tot seguit, la Quaresma donarà 49 voltes sobre si mateixa per acabar amb la disbauxa i inaugurar el període de penitència. La geganta de la Vella Quaresma és un element nou, però basat en una tradició antiga que estava perduda en l'oblit. Per les festes de Carnaval de 1988, concretament el Dimecres de Cendra, la geganta va sortir per primera vegada al carrer després de l'enterro del rei Carnestoltes, acompanyada per un nombrós grup de timbalers. I acabem amb esports. El Patronat Municipal d'Esports informa que la propera sortida de Marxa Nòrdica està prevista pel diumenge 8 de març amb punt d'inici al poble de Lilla. Es tracta d'una ruta circular d'uns 9 quilòmetres que travessarà dues comarques, la Conca de Barberà i l'Alt Camp, fins arribar als 785 metres d'altitud del cim de la Cogulla de Miramar. Les inscripcions es poden tramitar a la pàgina web del Patronat. I això és tot per avui. L'Infopòdcast Valls és una coproducció de Ràdio Ciutat de Valls i La Xarxa de Comunicació Local. Moltes gràcies per la seva atenció i fins demà.

Émission du 17/02/2026 présentée par Amaury de Tonquédec avec Géraldine METIFEUX, Associée Gérante chez ALTER EGALEet Sonia Elmlinger, Co-Fondatrice et Directrice Générale de Lilycare.frOn cotise tous aujourd'hui pour financer les retraités actuels. Mais le jour où ce sera notre tour, notre pension sera-t-elle vraiment à la hauteur de ce que nous avons versé ?Salarié ou indépendant, comment mettre toutes les chances de son côté pour se constituer une retraite capable de couvrir ses besoins et préserver son niveau de vie ?Vos questions en live : Retraite, carrière internationale et PEAQuel est l'impact des enfants sur la retraite des femmes : avantage ou pénalité ?Quelles conséquences d'une carrière à l'étranger sur la retraite et que faut-il anticiper avant le départ et au retour ?Est-il pertinent d'investir sur des valeurs européennes ou françaises via un PEA ?Indépendant, prévoyance et allocation 2026En cotisant moins en tant qu'indépendant, comment compenser une retraite plus faible ?Comment bien choisir sa prévoyance en cas d'accident ou d'arrêt de travail (franchise, durée, niveau de couverture) ?Quelle allocation privilégier en 2026 : encore les actions ? Faut-il s'exposer aux marchés émergents ?Jeune actif : PER ou PEALe PER est-il surtout intéressant pour les hauts revenus ?Quand on débute, faut-il privilégier le PEA ou ouvrir aussi un PER ?Et bien sûr, les QUESTIONS CASH !

In this captivating episode, we welcome Aleksander Czeszkiewicz, the extraordinary Polish researcher and author who authored his groundbreaking debut book at the remarkable age of just 17.Join us as Aleksander opens up about his profound personal transformation—from a committed atheist rooted in science and empirical evidence, to someone awakened by extraordinary supernatural experiences. As a child, he encountered unexplained high strangeness, only to set those mysteries aside in pursuit of rational understanding. But recurring dreams filled with premonitions and intense déjà vu became impossible to dismiss, ultimately unlocking extraordinary abilities such as perceiving human auras and witnessing energy manifested in visible light.This profound shift reshaped his worldview, raising provocative questions: Was this a form of divine guidance propelling him toward his mission? Could these experiences be the key to reexamining our ancient past and the very foundations of modern science?In Déjà Vu: Has Everything Already Been?, Aleksander masterfully intertwines timeless ancient myths—from the fabled lost continent of Atlantis to parallel global flood narratives—with perplexing archaeological enigmas, including the Great Pyramids and other megalithic marvels that continue to defy conventional scientific explanation.Challenging the conventional linear model of human progress, he presents compelling evidence for a cyclical view of history: advanced golden ages that flourished and vanished, erased by cataclysmic events near the close of the last Ice Age around 9,600 BCE.Discover why Aleksander's work is generating worldwide attention — and why the past may be more alive than we ever imagined!Book (US):https://www.amazon.com/dp/B0BGN8VZ3DBook (UK):https://www.amazon.co.uk/dp/B0BGN8VZ3Dhttps://www.czeszkiewiczglobal.comhttps://www.youtube.com/@czeszkiewiczglobalhttps://www.facebook.com/czeszkiewiczglobalGear up and get freaky with official Let's Get Freaky merchandise! Our spooky-cool collection features hoodies, t-shirts, mugs, stickers, and more—perfect for showing your love of the paranormal while staying comfy and stylish. Dive into the full range now: http://tee.pub/lic/aQprv54kktwGot a mind-blowing paranormal encounter, cryptid sighting, UFO experience, or any high-strangeness story that still gives you chills? We want to hear it—and we want YOU on the show! Become a guest on Let's Get Freaky and share your true story with our growing freaky community. Drop us a line at: letsgetfreakypodcast@mail.com Or slide into our DMs on socials: Facebook, Instagram, X, TikTok, or YouTube → @tcletsgetfreakypodcast Everything you need in one place: https://linktr.ee/letsgetfreaky

Confira os destaques de Os Pingos nos Is desta segunda-feira (16):O Partido Novo anunciou que entrará com uma Ação de Investigação Judicial Eleitoral (AIJE) no TSE para pedir a inelegibilidade do presidente Luiz Inácio Lula da Silva (PT). A sigla alega que o desfile da escola de samba Acadêmicos de Niterói, na Marquês de Sapucaí, configurou abuso de poder político e econômico. O Partido dos Trabalhadores (PT) divulgou uma nota oficial nesta segunda-feira (16/02/2026) rebatendo as acusações da oposição sobre o desfile da Acadêmicos de Niterói. O partido sustenta que a homenagem a Luiz Inácio Lula da Silva foi uma "manifestação espontânea de liberdade de expressão artística" e que não há fundamentos jurídicos para falar em inelegibilidade. O senador Carlos Viana (Podemos-MG), presidente da CPMI do INSS, anunciou que pretende se reunir com o ministro André Mendonça (STF) logo após o Carnaval para tratar do Caso Master. Com o fim do recesso de Carnaval, o Congresso Nacional retoma as atividades com uma agenda focada em temas de alto apelo popular e segurança pública. O presidente da Câmara, Hugo Motta (Republicanos-PB), confirmou que o fim da escala 6x1 e a PEC da Segurança Pública são as prioridades imediatas. A Federação das Indústrias do Rio de Janeiro (Firjan) emitiu um alerta contundente sobre os impactos econômicos da proposta que visa extinguir a escala 6x1. Segundo o vice-presidente da entidade, Antônio Carlos Vilela, a mudança pode gerar um custo adicional de R$ 180 bilhões por ano para a economia brasileira. O ministro Alexandre de Moraes (STF) autorizou nesta segunda-feira (16) a visita do deputado federal Guilherme Derrite (PP-SP) ao ex-presidente Jair Bolsonaro (PL), agendada para o dia 25 de fevereiro.Você confere essas e outras notícias em Os Pingos nos Is.

Welcome to Automating Quality, the life sciences–focused show that bridges the gap between automation and quality management. In this episode, our host Philippe welcomes Paul Michel, Senior Consultant at SkillPad, with over 27 years of experience in the pharmaceutical and biopharmaceutical industries, including more than two decades in manufacturing. Paul specializes in GMP training, compliance readiness, and supporting organizations through the complexities of product development and commercial manufacturing. Together, they explore the realities of GxP compliance in biopharma manufacturing — from the scientific complexity of biologics and evolving regulatory expectations to the growing demand for specialized quality skills and the expanding role of CDMOs. The conversation highlights how automation, digital maturity, and strong quality foundations are becoming essential to sustain growth in this fast-evolving sector.   Key Takeaways 02:11 Why biologics manufacturing is fundamentally more complex than small molecule production 04:10 How living cell systems introduce variability and demand tight process control 05:29 Why scale-up in biomanufacturing is scientifically challenging and risk-prone 10:00 The role of ICH Q5 guidelines and comparability studies in biologics compliance 13:06 The growing demand for advanced quality skills in biologics and digital environments 17:18 How modern CDMOs enable faster development from DNA to IND through platform approaches 20:47 Why automation and digitalization are critical to closing the CDMO capacity gap   Contact Paul Michel on LinkedIn here: Paul Michel (He/Him) | LinkedIn Contact us at solabs-podcast@solabs.com for questions or feedback!

DON McLEAN MARKS THE 55TH ANNIVERSARY OF “AMERICAN PIE” AS THE SURF BALLROOM ANNOUNCES A 2027 LIFE SIZE BRONZE STATUE HONORING THE ICONIC SINGER SONGWRITERStatue will be installed at the legendary venue where Buddy Holly, Ritchie Valens and J.P. “The Big Bopper” Richardson played their final showCLEAR LAKE, Ia. (February 3, 2026) — Fifty five years after its release, Don McLean's “American Pie” remains one of the most enduring anthems in American music — a sweeping, eight minute epic that captured a nation in transition and immortalized the phrase “the day the music died.” Today, as “American Pie” turns 55 (1971–2026), McLean is celebrating the milestone on tour while also helping propel a new chapter of preservation at the Surf Ballroom & Museum in Clear Lake, Iowa.The Surf Ballroom — the National Historic Landmark where Buddy Holly, Ritchie Valens and J.P. “The Big Bopper” Richardson performed on February 2, 1959 as part of the Winter Dance Party tour — announced that a life size bronze statue honoring McLean will be erected on-site in 2027. The statue will stand as a permanent tribute to the songwriter whose work helped carry the story of that night into global cultural memory, bridging generations of listeners, historians and music fans.The new statue is inspired from an existing life size bronze portrait created by acclaimed sculptor Zenos Frudakis (Philadelphia). Originally completed in 1989, the portrait was featured on the cover of McLean's album ‘Classics'. Frudakis, an acclaimed portrait sculptor and lifelong friend of McLean, is known the world over for his statues of Muhammad Ali, Nina Simone, President Dwight D. Eisenhower, and many more. He is creating an entirely new statue for public display at the Surf, adding a new landmark for visitors to the historic ballroom and its adjacent museum experiences. The announcement comes on February 3 on the heels of the 2026 Winter Dance Party at the Surf — the anniversary of the 1959 plane crash that claimed the lives of Holly, Valens and Richardson — a date forever intertwined with McLean's songwriting.“The Buddy Holly Educational Foundation is thrilled that one of our most iconic ambassadors is being honored with a statue at The Surf Ballroom, the site of Buddy Holly's final performance,” said Rick French, chairman of The Buddy Holly Educational Foundation and a national trustee of the famed Rock and Roll Hall of Fame. “While American Pie was famously inspired by the plane crash that claimed the lives of Buddy, Ritchie Valens and J.P. Richardson on February 3, 1959 , it has stood for more than half a century as an anthem to the cultural shifts of our country and is as relevant today as it has ever been.”The Buddy Holly Educational Foundation (TBHEF) works to extend musical education — including songwriting, production, arranging, orchestration and performance — to new generations regardless of income or learning levels. The Foundation also supports emerging artists through mentoring and songwriting retreats, and its Ambassadors receive a replica of Buddy Holly's own Gibson J 45 to encourage new music in his memory.“To this day Don remains one of Maria Elena Holly's closest friends and she was overjoyed to learn a statue is being cast in his honor,” added Peter Bradley, Jr., vice chairman of The Buddy Holly Educational Foundation, who is working closely with McLean, his management team and Jeff Nichols at the Surf Ballroom to plan a blockbuster unveiling of the statue upon completion.First opened in 1933 (and rebuilt in 1948 after a fire), the Surf Ballroom continues to host concerts and special events year round and welcomes visitors to explore the site's museum offerings. In recent years, the Surf expanded its educational mission with new immersive experiences honoring the artists and cultural moments that shaped early rock 'n' roll — ensuring that the ‘Winter Dance Party' story is preserved not only as history, but as a living, visitable place.DON McLEAN 2026 TOUR DATES (SUBJECT TO CHANGE):Fri, Feb 06 — Lobero Theatre — Santa Barbara, Calif.Sat, Feb 07 — Saban Theatre — Beverly Hills, Calif.Fri, Mar 20 — Seminole Casino Hotel Immokalee — Immokalee, Fla.Sat, Mar 21 — Maxwell C. King Center for the Performing Arts — Melbourne, Fla.Sun, Mar 22 — Savannah Center — The Villages, Fla.Mon, Mar 23 — Nancy and David Bilheimer Capitol Theatre — Clearwater, Fla.Sat, May 16 — Honeywell Center — Wabash, Ind.Fri, May 22 — Edmond Town Hall — Newton, Ct.Thu, May 28 — Riviera Theatre — North Tonawanda, N.Y.Fri, May 29 — Caesars Circus Maximus Theater — Atlantic City, N.J.Sat, Jun 06 — Westgate Las Vegas Resort & Casino — Las Vegas, Nev.Sat, Aug 01 — Murphy Theatre — Wilmington, OhioSat, Aug 22 — Indiana State Fairgrounds & Event Center — Indianapolis, Ind.For tickets and the latest updates, visit DonMcLean.com.Click Here to Subscribe to The Adventures of Pipeman for PERKS, BONUS Content & FREE GIVEWAYS! Pipeman in the Pit is a music, festival, and interview segment of The Adventures of Pipeman Radio Show (#pipemanradio) and from The King of All Festivals while on The Pipeman Radio Tour.Pipeman in the Pit features all kinds of music and interviews with bands & music artists especially in the genres of Heavy Metal, Rock, Hard Rock, Classic Rock, Punk Rock, Goth, Industrial, Alternative, Thrash Metal & Indie Music. Pipeman in the Pit also features press coverage of events, concerts, & music festivals.Pipeman Productions is an artist management company that sponsors the show introducing new local & national talent showcasing new artists & indie artists.Then there is The Pipeman Radio Tour where Pipeman travels the country and world doing press coverage for Major Business Events, Conferences, Conventions, Music Festivals, Concerts, Award Shows, and Red Carpets. One of the top publicists in music has named Pipeman the “King of All Festivals.” So join the Pipeman as he brings “The Pipeman Radio Tour” to life right before your ears and eyes.Would you like to be a sponsor of the show?Would you like to have your business, products, services, merch, programs, books, music or any other professional or artistic endeavors promoted on the show?Would you like interviewed as a professional or music guest on The Adventures of Pipeman, Positively Pipeman and/or Pipeman in the Pit?Would you like to host your own Radio Show, Streaming TV Show, or Podcast?PipemanRadio Podcasts are heard on Pipeman Radio, Talk 4 Media, iHeartRadio, Pandora, Amazon Music, Audible, Spotify, Apple Podcasts, and over 100 other podcast outlets where you listen to Podcasts.The following are the different podcasts to Follow, Listen, Download, Subscribe:•The Adventures of Pipeman•Pipeman Radio•Pipeman in the Pit – Music Interviews & Festivals•Positively Pipeman – Empowerment, Inspiration, Motivation, Self-Help, Business, Spiritual & Health & WellnessClick Here to Subscribe for PERKS, BONUS Content & FREE GIVEWAYS!Follow @pipemanradio on all socials & Pipeman Radio Requests & Info at www.linktr.ee/pipemanradioStream The Adventures of Pipeman daily & live Mondays, Tuesdays, Wednesdays at 1PM ET on W4CY Radio & Talk 4 TV. Download, Rate & Review the Podcast at The Adventures of Pipeman, Pipeman Radio, Talk 4 Media, iHeartRadio, Apple Podcasts, YouTube & All Podcast Apps.

Illinois joins three other Democrat-led states in suing the White House over public health funding cuts. Amazon announces drone delivery coming to southwest suburbs. Portage, Ind., unveils its pitch for a Bears stadium, as northwest suburban residents and mayors rally to secure a stadium in Arlington Heights. In the Loop breaks down those stories and more in our Weekly News Recap with WTTW Chicago politics reporter Heather Cherone, Chicago Sun-Times federal courts reporter Jon Seidel and Capitol News Illinois state government and politics reporter Hannah Meisel. For a full archive of In the Loop interviews, head over to wbez.org/intheloop.

Confira os destaques do Jornal da Manhã desta sexta-feira (13): O ministro Dias Toffoli deixou oficialmente a relatoria do inquérito que investiga as fraudes bilionárias no Banco Master nesta quinta-feira (12). A decisão foi anunciada após uma reunião administrativa de emergência convocada pelo presidente da Corte, Edson Fachin, que contou com a participação de todos os dez ministros. Em nota conjunta, os magistrados negaram a existência de suspeição ou impedimento legal de Toffoli, reafirmando o apoio institucional ao colega, mas informaram que o próprio ministro solicitou a redistribuição dos processos para preservar os “altos interesses institucionais” do tribunal diante do desgaste causado pelas recentes revelações. Para falar sobre o assunto, a Jovem Pan entrevista Gustavo Sampaio, professor de direito constitucional. Nesta quinta-feira (12), o presidente dos Estados Unidos, Donald Trump, afirmou em um post na rede social Truth Social que as relações entre Washington e a Venezuela têm sido “extraordinárias”, elogiando o secretário de Estado Marco Rubio e outros representantes do governo pela condução da política externa naquele país. Trump destacou que o petróleo venezuelano está “começando a fluir” e que grandes quantias de recursos, que não eram vistas há muitos anos, devem ajudar o povo venezuelano em breve. O vice-presidente e ministro da Indústria, Geraldo Alckmin, afirmou nesta quinta-feira (12) que é contra o projeto de lei que prevê a quebra de patentes do Mounjaro e do Zepbound, duas marcas de canetas emagrecedoras. A renúncia de Chris Wormald, secretário de gabinete e um dos principais nomes do governo britânico, aprofundou a crise enfrentada pelo primeiro-ministro Keir Starmer após novas revelações ligadas ao caso Jeffrey Epstein. Wormald se tornou o terceiro integrante da equipe a deixar o cargo em poucos dias. A situação ganhou ainda mais pressão após o nome de Peter Mandelson aparecer em fotos e extratos bancários associados ao escândalo. A Justiça suspendeu liminarmente regras das escolas cívico-militares do estado de São Paulo, sob argumento de que há evidência de violação ao princípio da legalidade, ofensa ao princípio da gestão democrática do ensino e potencial discriminatório. A deputada federal Adriana Ventura (Novo-SP) iniciou a coleta de assinaturas na Câmara dos Deputados para viabilizar a tramitação de uma Proposta de Emenda à Constituição que prevê a obrigatoriedade de códigos formais de conduta e integridade no Judiciário brasileiro. A proposta pretende estabelecer diretrizes éticas para ministros do STF e de outros tribunais superiores, ampliando mecanismos de controle e transparência institucional. O Governo de São Paulo lançou um alerta à população sobre os riscos do consumo de bebidas alcoólicas adulteradas durante o Carnaval. A campanha reforça a importância de comprar apenas em estabelecimentos regularizados, verificar a procedência dos produtos e evitar itens de origem desconhecida. Segundo o Centro de Vigilância Sanitária de São Paulo, ações de fiscalização serão intensificadas em parceria com vigilâncias municipais, responsáveis pela inspeção de comércios e vendedores ambulantes. Nesta sexta-feira (13), primeira noite do Carnaval em São Paulo, a Mocidade Unida da Mooca, estreante no grupo especial, abre os desfiles a partir das 23h, enquanto a Barroca Zona Sul será a última a entrar no sambódromo, com início previsto para as 5h30 de sábado (14). Ao todo, serão sete escolas na sexta e mais sete no sábado; das 14 agremiações que participam neste fim de semana, duas serão rebaixadas após a apuração das notas marcada para as 16h de terça-feira (17). Essas e outras notícias você acompanha no Jornal da Manhã. Learn more about your ad choices. Visit megaphone.fm/adchoices

In the final hour, Leila Rahimi and Marshall Harris were joined by Portage, Ind. mayor Austin Bonta to discuss his city's pitch to lure the Bears to build a new stadium there. After that, Rahimi and Harris explained why the Chiefs' move from Missouri to Kansas can't be a model for the Bears to follow as they explore where to build a new stadium.

Leila Rahimi and Marshall Harris were joined by Portage, Ind. mayor Austin Bonta to discuss his city's pitch to lure the Bears to build a new stadium there.

Kevin Hincks turns to movers affecting markets under the surface. On the jobless claims, he notes the number as little changed from the month prior, suggesting a jobs market finding its footing. In D.C., Kevin explains why he doesn't see the U.S. House on reversing Canada tariffs "going anywhere." ======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Confira os destaques do Jornal da Manhã desta quinta-feira (12): O presidente do Supremo Tribunal Federal, Edson Fachin, deverá avaliar se há conflito de interesse na atuação do ministro Dias Toffoli em um processo relacionado ao Banco Master. A análise ocorre após a Polícia Federal encontrar menções ao magistrado no celular do empresário Daniel Vorcaro, dono da instituição financeira. O gabinete do ministro do STF Dias Toffoli divulgou nota pública esclarecendo sua participação societária na empresa Maridt e negando qualquer relação pessoal ou financeira com Daniel Vorcaro, dono do Banco Master, alvo de investigações da Polícia Federal. Segundo o comunicado, a empresa é familiar, tem declarações regulares aprovadas e a administração é feita por parentes, sem atuação direta do magistrado na gestão. O texto também afirma que Toffoli jamais recebeu valores dos citados e não possui vínculos com investigados ou gestores mencionados no caso. O vice-presidente e ministro do Desenvolvimento, Indústria, Comércio e Serviços, Geraldo Alckmin, afirmou que um grupo de trabalho criado no Senado poderá aprimorar salvaguardas relacionadas ao acordo comercial entre Mercosul e União Europeia. Segundo Alckmin, as discussões serão conduzidas com cautela e o tratado, de forma geral, tende a trazer benefícios econômicos ao Brasil. O senador Renan Calheiros (MDB-AL) afirmou que o MDB pode apoiar a reeleição do presidente Lula (PT) caso o partido fique com a vaga de vice na chapa presidencial. Segundo ele, há maioria interna favorável à aliança. Entre os nomes cotados estão o governador do Pará, Helder Barbalho, e o ministro dos Transportes, Renan Filho. A possível mudança na vice-presidência também gera incômodo no PSB, partido do atual vice, Geraldo Alckmin. Associações ligadas ao Carnaval de rua de São Paulo pediram a revisão dos locais e trajetos dos desfiles após registros de superlotação e riscos de tumulto em eventos recentes. Em resposta, a Prefeitura anunciou a ampliação das ações de segurança e medidas para reduzir aglomerações durante a folia de 2026. O presidente Lula (PT) confirmou que se reunirá com Donald Trump nos Estados Unidos, em março, durante viagem oficial que também inclui passagens por Índia e Coreia do Sul. Segundo Lula, o encontro na Casa Branca não terá temas proibidos e servirá para discutir a relação bilateral, incluindo a questão tarifária já parcialmente revertida pelo governo brasileiro. A nova rodada da pesquisa Genial/Quaest divulgada nesta quarta-feira (11) mostra o presidente Luiz Inácio Lula da Silva liderando todos os cenários testados para as eleições presidenciais de 2026, tanto em primeiro quanto em segundo turno. O levantamento indica variações entre 35% e 39% das intenções de voto no primeiro turno e entre 42% e 44% em simulações de segundo turno. O senador e pré-candidato à Presidência, Flávio Bolsonaro (PL-RJ), afirmou que pretende promover um “tesouraço” nas despesas públicas para reduzir a carga tributária, estimular investimentos e incentivar o empreendedorismo. Ao mesmo tempo, o parlamentar disse que pretende manter programas sociais voltados à população de baixa renda, como o Bolsa Família. O Tribunal de Justiça de São Paulo decidiu recorrer da decisão do ministro do Supremo Flávio Dino, que mandou suspender os “penduricalhos” ilegais no serviço público. O órgão afirma que o Congresso precisa definir as regras que valham em todo o país, antes da suspensão dos pagamentos adicionais. Campanhas da direita e da esquerda têm monitorado pontos considerados sensíveis na disputa pelo governo de São Paulo. A avaliação é que alguns temas como o sistema de pedagio Free Flow e a privatização da Sabesp podem ganhar holofotes ao longo do processo eleitoral e influenciar o debate entre os candidatos. Essas e outras notícias você acompanha no Jornal da Manhã. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ataque em escola e casa deixa 10 mortos e 25 feridos no Canadá. Integrantes do Judiciário veem risco de desfile com samba-enredo de Lula no Rio parar na Justiça Eleitoral, e Planalto teme desgaste político. Câmara aprova criação de universidades federais do Esporte e Indígena. Frente fria avança no Sul e mantém chuva em várias regiões do Brasil nesta quarta. Britney Spears vende os direitos de todas as músicas de sua carreira, diz site.

How do you build an organization that can absorb change, learn from failure, and keep patients at the center—even when the science is uncertain? Nelly Viseux shares lessons from over 20 years in biotech and a decade leading cell and gene therapy development.Nelly discusses how she structured a 100-person CMC organization at Regeneron to balance innovation with operational execution, why documenting your assumptions is critical to managing risk, and what it really takes to maintain resilience when you're literally holding patient lives in your hands.A few of Nelly's key takeaways:Resilience is adaptability—build organizations that absorb and anticipate change rather than resist itSeparate innovation from execution with intentional gates for when new approaches are ready to implementDocument your assumptions so you can revisit decisions effectively when circumstances changeFailure is a process problem, not a personal one—root cause analysis should improve systems, not assign blameData is the common language that aligns scientists, regulators, and stakeholdersEveryone is a leader in cell therapy—manufacturing and QC teams hold patient lives in their handsAbout Nelly ViseuxNelly Viseux is Vice President of Cell Therapies Development, Manufacturing, Supply & Quality at Regeneron, leading a 100-person organization supporting autologous cell therapy programs. She has over 20 years of biotechnology experience spanning large pharma (Shire, Biogen, Baxter) and startups, working across cell and gene therapies, biologics, and nanoparticles. Her accomplishments include building a Phase 1 cell therapy manufacturing facility that achieved 100% cGMP success and first IND submission within two years. She holds a Ph.D. in Biochemistry and Molecular Biology from University of Lille and is a member of the Society for Immunotherapy of Cancer and the American Society of Gene & Cell Therapy.About The FDA GroupThe FDA Group helps life science organizations rapidly access the industry's best consultants, contractors, and candidates. Our resources assist in every stage of the product lifecycle—from clinical development to commercialization—with a focus on staff augmentation, auditing, remediation, QMS, and other specialized project work in Quality Assurance, Regulatory Affairs, and Clinical Operations. Learn more: ⁠⁠https://www.thefdagroup.com/

Las radios comunitarias Indígenas son una herramienta para la memoria, para la defensa del territorio, para asegurar la existencia de las lenguas originarias, de la música y de la cultura. Por esta razón, en el marco del Día Mundial de la Radio, en Radio de Derechos Indígenas queremos celebrarlas y presentar a algunas de nuestras emisoras socias. Puedes escuchar, descargar y compartir este programa de forma gratuita. Música de introducción: - Burn Your Village to the Ground” de The Halluci Nation. Derechos de autor, propiedad de The Halluci Nation. Usada bajo su permiso. Música de fondo: - “Rebeldía” de Corroncha Son. Derechos de autor, propiedad de Corroncha Son. Usada bajo su permiso. - “Mi radio favorita” de Amador Marín Alavez “El indio Mixteco”. Derechos de autor, propiedad de Amador Marín Alavez. Voces: - Unión de Mujeres Aymaras del Abya Yala, Perú. - Radio Tsinaka, México. - Radio Comunitaria Naköj, Guatemala. - Radio Waira, Colombia. - Red de la Diversidad, Bolivia. - Radio Pedro Ignacio Muiba, Bolivia. - Radio Werken Kurruf, Chile. - Guadalupe Pastrana, nahua, Cultural Survival, México. Producción, guión y edición: - Guadalupe Pastrana, nahua, Cultural Survival, México. Imagen: - Cultural Survival. Esta es una producción de Radio de Derechos Indígenas. Nuestros programas son gratuitos para escuchar, descargar y difundir.

Le formulaire pour poster tes questions : https://tally.so/r/pbBbz1

Neste podcast, eu comento dois ou três links selecionados da curadoria diária que faço no Manual do Usuário. Recomendo que você dê uma olhada no arquivo de links para descobrir mais links. Inteligência artificial no Firefox: bom ou nem?, 0:12 Controles de IA estão chegando ao Firefox (em inglês). Indústria da IA não aceita “não” como resposta. Site esquisito da Mozilla (em inglês). Notícias rápidas, 9:53 Notepad++ foi comprometido por hackers patrocinados por governos (em inglês), 9:53 Google confirma que que compatibilidade com AirDrop chegará a mais celulares Android (em inglês), 11:08 pandoc para as pessoas, 12:24

An Amazon data center is set to break ground in Hobart, Ind., this spring. Hobart Mayor Josh Huddlestun says the company will pay the $47 million upfront which could be used for infrastructure improvements. But residents say they still have not received a site plan and are asking for independent environmental impact studies. In the Loop hears from Angelita Soriano, a Hobart resident, and Jen Walling, executive director for the Illinois Environmental Council, which is supporting legislation that would put guardrails on data centers' impact on the environment. For a full archive of In the Loop interviews, head over to wbez.org/intheloop.

Debate da Super Manhã: Resultado de um processo histórico marcado pela colonização, políticas públicas centralizadas e investimentos econômicos desiguais ao longo do tempo. A região Nordeste do Brasil, historicamente, enfrenta uma distribuição desigual de recursos quando se comparado a outras regiões do país. No debate desta terça-feira (3), a comunicadora Natalia Ribeiro conversa com os nossos convidados para falar sobre os entraves e os gargalos do desenvolvimento nordestino, o crescimento econômico da região e a concentração de renda e de pobreza no Nordeste. Participam o superintendente da Superintendência do Desenvolvimento do Nordeste (Sudene), Francisco Alexandre, a economista, conselheira do Conselho Federal de Economia e do Conselho Regional de Economia em Pernambuco (Corecon/PE); e professora de Economia da Unicap, Ana Cláudia Arruda, e o ex-senador, ex-ministro do Desenvolvimento, Indústria e Comércio Exterior e ex-presidente da Confederação Nacional da Indústria (CNI), Armando Monteiro Neto.

Le positionnement est un fondamental : c'est ce qui fait qu'on vous identifie, et c'est qui vous évite de partir dans tous les sens. J'ai demandé à une autre podcasteuse de nous donner sa recette secrète, je vous demande d'accueillir tout de suite Laurie Giacobi.Autres épisodes qui pourraient vous plaire : Construire ses valeurs de marque avec Anthony BourbonC'est quoi la plateforme de marque ?---------------Pour travailler avec moi vous pouvez :> Choisir une formationStratégie Persona : Comprenez vos clientsStratégie Emailing : Faites décoller votre base emailsStratégie Indépendante : Communiquez en ligne (liste d'attente)Stratégie Advocacy : Donnez les clés de LinkedIn à vos employés (à venir)> Réserver une heure de conseils personnalisés> Devenir partenaire du Podcast du Marketing---------------

On this episode of Conservation Ag Update, brought to you by Martin-Till, Leopold Conservation Award recipient Jim Hershey shares some of his latest conservation tips and tricks from his Elizabethtown, Pa., farm. Fellow no-tiller Joseph Kern describes how planting green has transformed his operation in Mariah Hill, Ind.

Explore the work of the Princeton, Indiana producer and engineer Robert Hosea Williams (also known as R. José Williams) best known for his work with Gil Scott-Heron. Williams was born in 1936 in Princeton, Indiana, the county seat of Gibson County in the state's far southwestern corner. While his career would eventually take him far from southern Indiana, his family's roots in the region ran deep.  His mother, Martha Alice Stewart, came from one of Gibson County's long-established Black families. Her father, Hosea Henry Stewart, was born in Lyles Station, Indiana, one of the most significant Black settlements in the state.  Founded in the 1840s by free Black landowners, Lyles Station grew into a self-sustaining farming community with its own school, churches, businesses, and railroad access. For decades, it served as a center of Black life in the region.  Gibson County was home to several early Black settlements, formed by free Black families migrating from the South in the early 19th century. These communities emphasized land ownership, education, spiritual life, and mutual support—values passed down across generations, even as many rural settlements declined in the 20th century due to flooding, economic change, and migration into towns like Princeton.  Williams' family left Princeton in the late 1940s, but the values of self-determination and cultural pride rooted in Gibson County found their way into Williams' production work, reflected in the socially conscious music he produced for artists like Gil Scott-Heron and Father's Children.  In the early 1970s, Williams established himself as a recording engineer and producer in the Washington, D.C. area, building a career that placed him at the center of the city's vibrant but often overlooked soul and R&B scene. In D.C., Williams founded Red, Black and Green Productions, named after the Pan-African flag. Under that banner, he worked with many R&B and funk musicians clustered around the nation's capital, including Father's Children, The Summits, and Dyson's Faces. In 1973, Williams came to the attention of poet and singer-songwriter Gil Scott-Heron, who had been teaching at Federal City College in D.C. Scott-Heron had gained national prominence with his 1971 recording The Revolution Will Not Be Televised. Along with his musical collaborator Brian Jackson, Scott-Heron secured Williams as producer and engineer for his classic 1974 release, Winter in America. Join us for music featuring the engineer and producer Robert Hosea Williams.

What if the chocolate industry's reliance on equatorial farms—and the deforestation that comes with it—could be eliminated entirely? Plant cell bioreactors are doing that, producing real cacao without a single tree. But this isn't just about chocolate. It's about fundamentally rethinking how we manufacture food at scale, and the bioprocessing innovations emerging from this shift have implications far beyond the food industry.Steven Lang, Head of R&D at California Cultured, spent two decades mastering mammalian cell culture at biopharma giants like Johnson & Johnson and Genentech. Then he made a radical pivot: applying those same bioprocessing principles to cultivate plant cells for food production. His mission? Prove that cellular agriculture extends far beyond the cultivated meat narrative, and that plant cell manufacturing offers a faster, more economical path to market.At California Cultured, Steven's team is scaling cacao and coffee production using innovative low-cost plastic bioreactors instead of expensive stainless steel vessels. They've engineered plant cell media formulations that operate at a fraction of typical bioprocessing costs. And they're preparing to launch their first commercial product—high-flavanol cocoa powder—in 2026.What you'll discover in this episode:Why cellular agriculture ≠ cultivated meat (07:16) – Steven's frustration with the narrow definition that's holding the industry back, and why plant cell culture deserves equal attentionPlant vs. animal cell culture fundamentals (09:26) – Technical comparison: totipotent plant cells, callus formation, adaptation to suspension culture, and how cacao cell lines are developed from explantsAchieving 30-40% pack cell volume in 7-day batches (11:14) – Process parameters: ambient temperature growth, low pH environments, minimal downstream processing, and maintaining product consistency without genetic modificationThe economics that change everything (14:38) – How plant cell media costs and simple raw material requirements create commodity-scale economicsThe Tesla model for biotech (15:58) – Strategic rationale for launching with premium high-flavanol cocoa powder first, then using that revenue runway to optimize for commodity pricingLow-cost bioreactor innovation (18:23) – Why plastic vessels beat stainless steel, contamination management in low-pH cultures, and scale-out strategy over traditional scale-upDecentralized biomanufacturing (23:10) – Converting underutilized office space into production facilities, onshoring food ingredient production, and what this means for emerging markets and supply chain resilienceThe bigger picture beyond cacao (24:23) – Four approved drugs already produced via plant cell culture, the expanding landscape of ingredients (saffron, ginseng, echinacea), and why stage-appropriate models matter for cellular agriculture's futureThe strategic insight:While the cultivated meat industry struggles with cost structures and consumer acceptance, plant cell manufacturing is quietly proving the business model. The lesson for bioprocessing professionals? Sometimes the fastest path to commercialization isn't the most obvious one, and the innovations happening in food manufacturing today could reshape how we think about bioproduction economics across industries.Here is the previous conversation with Steven Lang:Episodes 55-56: Cultivated Meat: A Promising Future or an Inevitable Bubble? with Steven LangConnect One bad CDMO decision can cost you two years and your Series A. If you're navigating tech transfer, CDMO selection, or IND prep, let's talk before it gets expensive. Two slots open this month.Support the show

Welcome back to "First Draft." Hosted by Mike Greenberg, Field Yates and Mel Kiper Jr., we're breaking down the rest of Mel's first Mock Draft of the 2026 Class. (0:00) Welcome to First Draft (1:00) Drake Maye & Sam Darnold's ascension (4:07) Recapping top-10 picks (5:00) No. 11: Dolphins select DE Keldric Faulk (8:22) No. 14: Ravens select WR Makai Lemon (13:34) No. 15: Buccaneers select TE Kenyon Sadiq (18:10) No. 16: Jets select QB Ty Simpson (via IND) (27:47) No. 19: Panthers select LB CJ Allen (30:58) No. 20: Cowboys select DE Akheem Mesidor (via GB) (34:30) Picks 21-24 (35:04) No. 25: Bears select DT Kayden McDonald (37:55) No. 26: Bills select WR Chris Brazzell II (41:23) No. 29: Rams select OT Monroe Freeling (46:27) Picks 30-32 (47:00) Final thoughts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Avec cet épisode, je vous propose un résumé du livre Company of One de Tom Jarvis, qui nous explique comment travailler seul ou avec une équipe très restreinte. J'ai adoré ce livre qui reflète par beaucoup de point la vie que je me suis choisie. Autres épisodes qui pourraient vous plaire : The One ThingLa semaine de 4 heures---------------Pour travailler avec moi vous pouvez :> Choisir une formation✓ Stratégie Persona : Comprenez vos clients✓ Stratégie Emailing : Faites décoller votre base emails✓ Stratégie Indépendante : Communiquez en ligne (liste d'attente)✓ Stratégie Advocacy : Donnez les clés de LinkedIn à vos employés (à venir)> Réserver une heure de conseils personnalisés> Devenir partenaire du Podcast du Marketing---------------

The America's Work Force Union Podcast welcomed Mike Leda, Business Manager of the International Brotherhood of Electrical Workers Local 153, to highlight the remarkable growth and evolution of his local in South Bend, Ind. Representing about 1,400 members across Northern Indiana and parts of Michigan, IBEW Local 153 has seen surging interest in the electrical trades and a booming apprenticeship program. On this episode of the America's Work Force Union Podcast, Richard Shavzin, 1st Vice President of the SAG-AFTRA Chicago Local and Executive Board member of the Illinois AFL-CIO, discussed artificial intelligence. The conversation covered the implications for union performers and the broader creative sector, potential job security risks, personal agency concerns and the rapidly evolving legal landscape as AI reshapes entertainment and media. Shavzin drew on his decades of industry experience and recent service on Governor Pritzker's AI task force, which he said put him in a vital role as an advocate for labor in the new age of technology.

Welcome back to "First Draft." Hosted by Mike Greenberg, Field Yates and Mel Kiper Jr., we're conducting a 2026 NFL end-of-regular-season Mock Draft. (0:00) Welcome to First Draft (1:00) Biggest surprise of Top-10 (3:46) No. 1: Raiders select QB Fernando Mendoza (6:53) No. 2: Jets select QB Dante Moore (10:07) No. 3: Cardinals select RB Jeremiyah Love (15:19) No. 4: Titans select LB Arvell Reese (17:24) No. 5: Giants select OT Francis Mauigoa (19:24) No. 6: Browns select WR Carnell Tate (25:00) No. 7: Commanders select Edge David Bailey (26:50) No. 8: Saints select Edge Rueben Bain Jr. (28:48) No. 9: Chiefs select WR Jordyn Tyson (30:11) No. 10: Bengals select S Caleb Downs (32:41) No. 11: Dolphins select CB Mansoor Delane (34:11) No. 12: Cowboys select Edge Keldric Faulk (36:39) No. 13: Rams select CB Jermod McCoy (via ATL) (40:49) No. 14: Ravens select WR Makai Lemon (42:21) No. 15: Buccaneers select LB Sonny Styles (43:43) No. 16: Jets select DT A'Mauri Washington (via IND) (44:59) No. 17: Lions select DE Akheem Mesidor (47:40) No. 18: Vikings select TE Kenyon Sadiq (49:03) Final thoughts! Learn more about your ad choices. Visit podcastchoices.com/adchoices