Podcasts about MTOR

STOP intermittent fasting if you think it automatically keeps you young. In this episode, you'll learn why short-term fasting results can mislead long-term aging outcomes, and how duration, frequency, refeeding, and protein intake determine whether fasting supports longevity or quietly accelerates decline. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Valter Longo, one of the world's leading longevity researchers with over 30 years of experience studying aging, nutrition, and disease prevention. Dr. Longo is the Director of the Longevity Institute at the University of Southern California's Leonard Davis School of Gerontology and the Director of the Longevity and Cancer Program at IFOM, the Italian Foundation for Cancer Research Institute of Molecular Oncology in Milan. He is the author of the bestselling book The Longevity Diet and was named one of TIME Magazine's 50 most influential people in health care for his research on fasting-mimicking diets. Together, Dave Asprey and Dr. Longo explain why many people focus too heavily on short-term effects and extrapolate them incorrectly across a lifetime. They break down how intermittent fasting differs biologically from multi-day fasting, why five-day fasting cycles trigger deeper cellular changes, and how insulin, IGF-1, mTOR, and growth hormone shape aging, regeneration, and disease risk over time. The conversation covers protein and amino acid intake, muscle preservation, frailty risk, and the tradeoffs between strength, function, and longevity. They explore ketosis, fasting-mimicking diets, stem cell activation, mitochondrial function, neuroplasticity, and why equilibrium and cycling matter more than constant restriction. Dave and Valter also discuss supplements, nootropics, creatine, carnivore-style eating, metabolism, sleep optimization, and how AI may eventually personalize fasting and nutrition based on individual biology rather than population averages. You'll learn: • Why short-term fasting benefits do not predict long-term longevity • How fasting duration changes gene expression and cellular regeneration • The difference between intermittent fasting and multi-day fasting • How protein and amino acids influence mTOR, IGF-1, and aging • Why muscle, strength, and longevity must be balanced, not maximized • When ketosis overlaps with fasting and when it does not • Why supplements can disrupt biological equilibrium • How AI could support future personalization in fasting and nutrition Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • BEYOND Conference 2026 | Register now with code DAVE300 for $300 off at https://beyondconference.com/• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.• Caldera + Lab | A small habit with big results. Go to https://CalderaLab.com/DAVE and use code DAVE for 20% off your first order.• Timeline | Go to https://timeline.com/Dave for 20% off.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: intermittent fasting longevity, fasting mimicking diet, fasting and aging science, biohacking fasting podcast, longevity fasting research, protein restriction longevity, amino acids aging, mTOR IGF-1 longevity, mitochondria aging science, neuroplasticity fasting, ketosis fasting science, metabolism longevity podcast, anti-aging fasting, functional medicine longevity, supplements fasting debate, nootropics brain optimization, muscle frailty aging, sleep optimization longevity, AI personalized nutrition, carnivore diet longevity debate, Dave Asprey fasting, Valter Longo longevity, longevity diet podcast, human performance aging Resources: • Learn More About Valter's Work At: https://valterlongo.com/ • Join My Fasting Challenge: https://daveasprey.com/#14-day • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 Introduction & Aging Fundamentals 4:36 Fasting Mimicking Diet Overview 7:03 Insulin, IGF-1 & mTOR 11:03 Body Fat & Fasting Frequency 17:08 The Protein Debate 20:22 Blue Zones & Centenarian Evidence 23:10 Amino Acids & Leucine 30:30 Growth Hormone & Longevity 34:01 Five-Day Fasting Benefits 40:55 Personalization & AI 42:29 Plant-Based Concerns 49:07 Fasting Risks & Limits 53:05 Supplements & Equilibrium 1:03:05 Ranking Longevity Pathways 1:05:05 Modern Environmental Challenges 1:16:21 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today's episode, Neil Iyengar, MD, moderated an OncLive Insights discussion about adverse effect management when using breast cancer therapies targeting the PI3K, AKT, and mTOR pathways. Dr Iyengar is an associate professor in the Department of Hematology and Medical Oncology and co-director of Breast Medical Oncology in the Department of Hematology and Medical Oncology at Emory University School of Medicine; as well as director of Survivorship Services at the Winship Cancer Institute of Emory University in Atlanta, Georgia. He was joined by Heather Moore, CPP, PharmD, a clinical pharmacist practitioner at the Duke Cancer Center Breast Clinic in Durham, North Carolina; and Sarah Donahue, MPH, NP, a nurse practitioner at the University of California San Francisco Health.  In our exclusive discussion, the experts highlighted the importance of early and comprehensive testing (using both tissue and liquid biopsies) for genetic alterations to guide treatment decisions. They also noted strategies for managing diarrhea, including patient education on diet, proactive use of loperamide, and regular monitoring. They also explained that hyperglycemia management should hinge on prophylactic use of metformin or SGLT2 inhibitors, dietary restrictions, and frequent glucose monitoring. Their conversation on rash management included insights about prophylactic antihistamines, patient education on skin care, and involving dermatology for severe cases. Overall, the experts spotlighted the importance of multidisciplinary collaboration and proactive patient education when treating patients with breast cancer.

In this paradigm-shifting episode of Beauty Bytes, I sit down with Dr. Rahul Mehta, the co-founder of Rapalogix Health and former head of R&D at SkinMedica. We dive deep into the future of cellular longevity and why the "do more, laser more, peel more" approach might actually be exhausting your fibroblasts.Dr. Mehta explains the science behind mTOR, the master regulator of our cell cycle, and how constantly keeping it in "growth mode" prevents our skin from repairing itself. We discuss his breakthrough molecule, RLX-201 (Re-!), which inhibits TORC1 to trigger repair pathways without the side effects of systemic rapamycin.We also cover the fascinating data showing how this technology made 56-year-old fibroblasts morphologically resemble 23-year-old cells, effectively reversing cellular aging rather than just masking it.

Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you'll learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports long-term longevity. This conversation reframes biohacking, anti-aging, and health from weight loss to muscle span, the length of time you live with strong, functional skeletal muscle. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Gabrielle Lyon, an accomplished physician and New York Times bestselling author of Forever Strong: A New, Science-Based Strategy for Aging Well, and author of the upcoming The Forever Strong Playbook, releasing January 27, 2026. Dr. Lyon pioneered the Muscle-Centric Medicine® approach, which places muscle at the center of disease prevention, metabolic health, and true vitality. She has trained elite athletes, military operatives, and public figures, while also living this philosophy at home as a mother of two with her husband, a retired Navy SEAL. Together, they break down why intermuscular fat may matter more than body fat percentage, how skeletal muscle drives insulin sensitivity and lowers inflammation, and why becoming physically stronger improves brain function and neuroplasticity. They explore protein needs across the lifespan, fasting, ketosis, carnivore-style nutrition, supplements, sleep optimization, and the real tradeoffs of GLP-1 drugs, including the risk of accelerated muscle loss if strength and protein are neglected. The conversation also covers mindset, hormesis, and why physical resilience creates emotional regulation and clearer decision-making in a world increasingly shaped by AI and convenience. This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, mitochondria, neuroplasticity, nootropics, metabolism, functional medicine, anti-aging strategies, supplements, and living Smarter Not Harder, ideally with a cup of Danger Coffee in hand. You'll Learn: • Why your glutes and skeletal muscle are critical drivers of longevity and brain health • Why intermuscular fat can matter more than body fat percentage for metabolic dysfunction • How strength training improves neuroplasticity, cognition, and emotional resilience • Why protein needs increase with age and why outdated limits can hold you back • What GLP-1 drugs get right, where they fail, and how to protect muscle span • Why progressive stimulus beats lifting heavy for long-term strength and injury prevention • How sleep optimization and recovery support mitochondria and human performance • How building muscle creates clarity, resilience, and better decision-making Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! Quantum Upgrade | Support your brain, energy, focus, sleep, and recovery with Quantum Upgrade, a 24/7 streaming quantum energy service designed to work continuously in the background. Try it free for 15 days with no credit card required: https://quantumupgrade.io/DAVE Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. KillSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com and use code DAVE for 20% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: muscle longevity organ, glutes brain health, strength training longevity podcast, muscle span aging, intermuscular fat metabolism, IMAT insulin resistance, skeletal muscle brain function, neuroplasticity strength training, protein intake aging, high protein diet longevity, metabolism muscle health, mitochondria muscle brain, muscle centric medicine podcast, gabrielle lyon podcast, forever strong playbook, women strength training longevity, GLP-1 muscle loss, sarcopenia aging prevention, resistance training brain health, sleep optimization muscle recovery, fasting ketosis muscle health, carnivore diet muscle metabolism, functional medicine muscle health, biohacking strength longevity, human performance muscle, anti-aging strength training, supplements muscle recovery, progressive stimulus training, blood flow restriction training, muscle resilience mindset Resources: • Get Gabrielle's NEW book Forever Strong: https://drgabriellelyon.com/forever-strong/ • Gabrielle's Website: https://drgabriellelyon.com/ • Follow Gabrielle's Instagram: https://www.instagram.com/drgabriellelyon/ • Gabrielles Youtube: https://www.youtube.com/@DrGabrielleLyon • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Introduction 1:01 – The Playbook vs Workbook 3:47 – Protein & Metabolic Health 6:21 – Mindset & Negativity 7:20 – Histamines & Hot Flashes 10:49 – Women & Strength Training 13:40 – Connective Tissue & EDS 16:15 – Muscle Span & Aging 19:41 – Training for Kids 21:55 – Pain Cave & Discomfort 25:25 – Emotional Regulation 29:46 – Resilience & Dating 32:11 – Building Friction & Discernment 35:47 – Self-Denial vs Awareness 41:03 – Mitochondria & Energy 42:46 – Bigger Booty, Bigger Brain 44:52 – Body Fat vs IMAT 49:01 – Measuring Muscle Health 52:08 – GLP-1s & Muscle Loss 56:12 – Protein Absorption Myths 59:30 – mTOR & Protein 1:01:29 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us a textThe AMP kinase pathway's role in cellular energy sensing, nutrient allocation, and its connections to health practices like fasting, exercise, and diet.TOPICS DISCUSSED:Cellular energy basics: ATP/ADP/AMP as energy currencies; AMP kinase activates on low ATP to conserve and redirect resources, like a budget manager.AMP kinase mechanics: Heterotrimeric enzyme phosphorylating 100+ substrates; localizes dynamically in cytosol, mitochondria, nucleus to integrate signals.Nutrient detection: Senses fatty acids in fasting/ketogenic states, boosting fat oxidation and mitochondria independent of energy drops.Fasting/exercise impacts: Elevate AMP kinase for mitophagy, better fuel switching; mimic historical scarcity absent under modern constant feeding.mTOR relationship: AMP kinase inhibits mTOR to stop growth in low energy states; feedback loop disrupted by abundance, promoting tissue buildup.Disease links: Low AMP kinase in obesity/diabetes reduces flexibility; activation prevents cancer but may aid tumor survival in therapy.Drugs/diets: Metformin and GLP-1s like Ozempic activate AMP kinase for glucose control/weight loss; ketogenic diets activate at intermediate levels for fat efficiency.ABOUT THE GUEST: Gregory Steinberg, PhD is a Professor of Medicine at McMaster University and co-directs the Centre for Metabolism, Obesity, and Diabetes Research, focusing on cellular energy sensors like AMP kinase.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code TRIKOMES for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.   Use code NAT10 for 10% off products at https://alchemiqlabs.com/   Episode Timestamps: Welcome and episode introduction ... 00:00:00 Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55 Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27 Explaining and balancing AMPK and mTOR for performance ... 00:13:03 Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18 Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04 Assessing recovery capacity and individualizing protocols ... 00:26:02 Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57 Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00 Differentiating bodybuilder vs. longevity approaches ... 00:34:44 Integrating peptides and support molecules into routines ... 00:40:44 Ketone esters and mitochondrial peptide interventions ... 00:41:20 Cautions on stacking and combining interventions ... 00:54:04 Lessons learned from overdoing interventions ... 01:05:02   Our Amazing Sponsors: Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.   BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.   Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

In episode 181 of the Fit Mother Project Podcast, Dr. Anthony Balduzzi kicks off a powerful new solo teaching series with a message that cuts straight to the core: after 40, muscle is not optional. It is the master regulator of aging, metabolism, hormones, and long-term independence - even for women.Dr. Balduzzi explains why aging is not about birthdays, but about muscle loss — and how strength training directly improves fat loss, insulin sensitivity, mitochondrial health, joint integrity, nervous system resilience, and even brain function. This episode reframes exercise from a “nice to have” into a foundational survival skill for modern life.If you want to feel stronger, leaner, more energized, and mentally sharp in 2026 and beyond, this episode will permanently change how you think about training — and why building muscle may be the single most important health decision you make this year.Rate & Review: If this episode resonated, please leave a 5-star rating and short review — it helps us reach more families.Join the Community: Visit www.fitmotherproject.com to train with us inside the programs.Next Week's Episode: Tune in next week for Part 2 — Why Insulin Sensitivity Changes Everything.Key TakeawaysMuscle is the master regulator of aging after 40Aging is driven by muscle loss, not chronological yearsStrength training improves fat loss by raising metabolic capacityMuscle acts as a glucose reservoir and improves insulin sensitivityMyokines released from muscle support healthy hormonesLow testosterone is epidemic — muscle is part of the solutionJoint pain often reflects muscle weakness, not joint damageGrip strength strongly predicts lifespan and independenceResistance training triggers mitochondrial biogenesisExercise activates longevity pathways: mTOR, AMPK, sirtuinsMuscle training strengthens the nervous system and brainProgressive resistance is essential for continued adaptationConsistency matters more than extreme intensityRecovery, sleep, and protein drive long-term gainsCreatine is a simple, safe, evidence-based support supplementBEAM Minerals—What a Difference!See what Beam Minerals can do for your health at beamminerals.com/fitfamily. Be sure to use the code FITFAMILY for 20% off your first order.Take an Adventure with FMP in 2026!Belize Service Trip — June 6-12, 2026. For information:

In episode 272 of the Fit Father Project Podcast, Dr. Anthony Balduzzi kicks off a powerful new solo teaching series with a message that cuts straight to the core: after 40, muscle is not optional. It is the master regulator of aging, metabolism, hormones, and long-term independence.Dr. Balduzzi explains why aging is not about birthdays, but about muscle loss — and how strength training directly improves fat loss, insulin sensitivity, mitochondrial health, joint integrity, nervous system resilience, and even brain function. This episode reframes exercise from a “nice to have” into a foundational survival skill for modern life.If you want to feel stronger, leaner, more energized, and mentally sharp in 2026 and beyond, this episode will permanently change how you think about training — and why building muscle may be the single most important health decision you make this year.Rate & Review: If this episode resonated, please leave a 5-star rating and short review — it helps us reach more families.Join the Community: Visit www.fitfatherproject.com to train with us inside the programs.Next Week's Episode: Tune in next week for Part 2 — Why Insulin Sensitivity Changes Everything.Key TakeawaysMuscle is the master regulator of aging after 40Aging is driven by muscle loss, not chronological yearsStrength training improves fat loss by raising metabolic capacityMuscle acts as a glucose reservoir and improves insulin sensitivityMyokines released from muscle support healthy hormonesLow testosterone is epidemic — muscle is part of the solutionJoint pain often reflects muscle weakness, not joint damageGrip strength strongly predicts lifespan and independenceResistance training triggers mitochondrial biogenesisExercise activates longevity pathways: mTOR, AMPK, sirtuinsMuscle training strengthens the nervous system and brainProgressive resistance is essential for continued adaptationConsistency matters more than extreme intensityRecovery, sleep, and protein drive long-term gainsCreatine is a simple, safe, evidence-based support supplementBEAM Minerals—What a Difference!See what Beam Minerals can do for your health at beamminerals.com/fitfamily. Be sure to use the code FITFAMILY for 20% off your first order.Take an Adventure with FFP in 2026!Fit Father Sedona Retreat — April 2026....

Send us a textHow agricultural practices influence the nutrient density of foods, particularly meat, and the importance of hidden compounds beyond standard nutrition labels.TOPICS DISCUSSED:Nutrient density profiling: Labs analyze thousands of compounds beyond macros and vitamins; this “dark matter” includes phytonutrients that may support health despite not being essential.Phytonutrients in foods: Plant secondary metabolites like polyphenols act as antioxidants and influence pathways like mTOR; animals convert plant compounds into bioactives humans access via meat.Red meat definition: Refers to meats high in myoglobin, including beef and lamb; most meats are red in wild forms, but human intervention affects color and classification.Ruminant animals: Animals like cows that have multi-chambered stomachs to digest plants; this metabolism differs from non-ruminants (e.g. chickens), affecting nutrient profiles in their meat.Grass-fed vs. grain-fed beef: Grass-fed has higher omega-3 fats and phytonutrients from diverse plants; studies show it improves human omega-6:3 ratios and biomarkers from grass-fed, pastured-raised animals.Farming practices & variations: Plant diversity boosts beef nutrients.Upcoming research: Long-term trials on effects of pasture-raised foods on human health; interactive dashboards for farmers to profile nutrients and inform policy.ABOUT THE GUEST: Stephan Van Vliet, PhD is an Assistant Professor in the Department of Nutrition, Dietetics, and Food Sciences at Utah State University, where he directs the Center for Human Nutrition Studies, focusing on linking food production systems to nutrient profiles and conducting clinical trials on health impacts.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Tuberous sclerosis complex is a rare genetic condition caused by changes in the TSC1 or TSC2 gene that over-activate a key growth-control pathway, known as mTOR. This leads to seizures that often don't respond to existing medicines and to noncancerous tumors in organs such as the brain, kidneys, lungs, and skin. In fact, more than 65 percent of people with TSC-related epilepsy still have seizures despite available treatments. Though mTOR inhibitors can help some patients, their benefits are limited because of side effects due to their lack of specificity. Aeovian Pharmaceuticals is developing an experimental therapy that precisely targets the overactive part of this pathway and avoids the part thought to cause many side effects. We spoke to Allison Hulme, CEO of Aeovian Pharmaceuticals, about tuberous sclerosis complex, the problems with existing therapies for seizures related to the condition, and the opportunity for its next-generation, selective mTOR inhibitors to treat tuberous sclerosis complex and beyond.

You're about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other and the science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, and anti aging without all the tribal thinking that can plague modern health conversations! Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dan Buettner for a rare co hosted podcast that explores where biohacking and Blue Zones philosophy clash and where they surprisingly align. Dan Buettner is a National Geographic Explorer, Emmy Award winning producer, and five time New York Times bestselling author. He is best known for identifying the Blue Zones, regions of the world where people live the longest and healthiest lives. His research has reshaped cities, healthcare systems, and insurance models across the United States, improving health outcomes for more than 10 million Americans. His Netflix series Live to 100: Secrets of the Blue Zones earned six Emmy nominations and won three. Dan is also an accomplished endurance athlete with three Guinness World Records in distance cycling. Together, Dave and Dan debate the true limits of human lifespan, whether longevity is driven more by environment or intervention, and how modern tools like AI, functional medicine, supplements, fasting, ketosis, and sleep optimization compare to walkable communities, movement, and purpose. They explore mitochondria, neuroplasticity, metabolism, brain optimization, and why Smarter Not Harder applies whether you follow a carnivore leaning diet, a bean based diet, or something in between. This episode gives you both sides of the longevity argument and lets you decide what fits your biology, values, and goals. You'll Learn: • Why Dan believes average human lifespan likely tops out in the mid 90s and how Blue Zones support longevity without chronic disease • Why Host Dave Asprey believes biohacking, AI, and modern science could push longevity toward 150, 180, or beyond • How environmental design hacks unconscious behavior more effectively than willpower • The overlooked role of light, darkness, and circadian rhythm in sleep optimization and human performance • How fasting and ketosis support longevity when used strategically instead of obsessively • Why mitochondria signaling may matter more than fixing every cell individually • How neuroplasticity and brain optimization influence aging and resilience • Where supplements and nootropics help and where simplicity wins • The real debate around carnivore diets, carbs, beans, metabolism, and longevity • Why community, purpose, and movement remain foundational even in advanced biohacking • How Danger Coffee fits into energy, focus, and Smarter Not Harder performance strategies Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! - BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. - Puori | Use code DAVE at http://puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity debate, biohacking vs blue zones, dave asprey dan buettner, human lifespan limits, how long can humans live, anti aging science, blue zones longevity, environment vs intervention longevity, human performance optimization, mitochondria signaling, aging clocks epigenetics, neuroplasticity aging, brain optimization longevity, sleep optimization circadian rhythm, fasting longevity science, intermittent fasting longevity, ketosis metabolism aging, AI longevity tools, AI exercise training, VO2 max lifespan, metabolism optimization, supplements longevity, nootropics brain health, carnivore diet longevity, beans vs meat longevity, protein mTOR aging, functional medicine longevity, community purpose lifespan, movement vs exercise longevity, light exposure circadian health, darkness sleep longevity, daveasprey biohacking, dan buettner blue zones, smarter not harder longevity, danger coffee performance Resources: • Dan's new podcast: https://danbuettner.com/podcast/ • Dan's website: https://danbuettner.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 2:50 – Introduction to Dan Buettner 4:59 – Light & Circadian Biology 7:21 – Aging Science & Interventions 13:18 – Community & Social Connection 15:16 – Biohacking Basics 19:04 – Movement & Exercise 21:20 – Diet & Nutrition Philosophy 31:06 – Dave's Daily Diet 33:49 – Salt & Hydration 41:07 – Marketing & Building Bulletproof 49:10 – Rapid Fire Round 55:00 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us a textCellular metabolism, mitochondrial health, and the roles of diet and environment in metabolic health, fetal & child development, and Alzheimer's.TOPICS DISCUSSED:Cellular growth vs. burning: Cells alternate between growing (using glucose for building blocks in low-oxygen environments) and burning (generating ATP in mitochondria with oxygen); dysregulation leads to metabolic issues.Key regulatory enzymes: PI3 kinase imports glucose, AMP kinase builds mitochondria, and mTOR drives cell division; their synchronization determines healthy modes, while desynchronization causes diseases.Fructose as a dose-dependent mitochondrial toxin: High fructose intake inhibits AMP kinase, reducing mitochondrial function and diverting energy to fat storage; it is dose-dependent, like alcohol, and unnecessary in the diet.Obesogens & endocrine disruptors: Chemicals like tributyltin (TBT) alter gene expression across generations, promoting obesity unrelated to calories; modern exposures increase reactive oxygen species (ROS), burdening cells.Fetal & neonatal development: Maternal diet, especially high sugar or formula feeding, can cause neonatal obesity and fatty liver; breastfeeding supports proper jaw development and oxygen intake.Brain metabolism & Alzheimer's: The brain's high energy needs make it vulnerable to mitochondrial issues and ROS; energy deficits from diet, stress, and toxins lead to synapse loss and inflammation, treatable via prevention.ROS & health: Mitochondria produce ROS as a byproduct of ATP generation; excess from diet or environment causes damage, but antioxidants and lifestyle can mitigate risks.PRACTICAL TAKEAWAYS:Limit added sugars in your diet to reduce mitochondrial stress and ROS, focusing on whole foods over ultra-processed items for better metabolic health.Prioritize breastfeeding for infants when possible to support proper physical development and reduce future metabolic risks.Incorporate regular exercise and social activities to manage stress and boost brain-protective factors like BDNF, aiding neurodegeneration prevention.Get adequate sleep to regulate cortisol and maintain cellular energy balance, helping prevent brain fog and chronic diseases.ABOUT THE GUEST: Robert Lustig, MD is a pediatric endocrinologist and Professor Emeritus at the University of California, San Francisco, with a background in neuroendocrinology and obesity research.*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

In this visionary episode of Beauty Bytes, I am saying goodbye to the "filler fatigue" of 2025 and unveiling my Top 10 Aesthetic Predictions for 2026. This isn't just about trends; I'm mapping out a paradigm shift toward hyper-personalization and regenerative medicine that will change how we treat aging forever. I explain why the era of overfilling is dead and how I am pivoting to "undetectable" results using micro-tox, strategic lifting, and collagen biostimulators. I also explore the cutting-edge future of AI diagnostics, where digital avatars will allow me to simulate your aging trajectory and show you treatment outcomes years in advance . We dive deep into the science of skin senescence, targeting "zombie cells" to restore resilience rather than just treating wrinkles . From turning on your body's mTOR cycles for cellular repair to the rise of collagen banking for Gen Z, I'm sharing exactly where the world of aesthetics is heading next year.

Muscle isn't just for movement: it's your body's largest metabolic organ.   In this episode, we explore the science behind FIT, the peptide that helps your body maintain and rebuild muscle by communicating directly with its repair systems. Learn how FIT inhibits myostatin, activates mTOR, and uses cofactors like vitamin D and magnesium to restore your body's ability to synthesize muscle.   We'll discuss how this peptide differs from supplements, what kind of changes to expect in the first weeks and months, and why protecting muscle is the single most effective strategy for metabolic health and longevity.   Hosted by Leanne Vogel.   Coaching and other supports available at: https://shop.healthfulpursuit.com/    Podcast Sponsors, links and offers available at: https://www.healthfulpursuit.com/podcast/  Bioactive Peptides: https://www.healthfulpursuit.com/make

Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠Today's episode is all about a peptide called Thymogen. Sometimes you'll see it spelled Thymagen, but I've always preferred “Thymogen” because it just rolls off the tongue. Either way, we're talking about a bioregulator peptide that works specifically on the immune system, and it's one that's been floating around research circles for a while… but I haven't gone deep on it until now.Most of you have heard me talk about Thymalin — and I love Thymalin. I've used it a lot, and in certain use cases I even like it more than Thymosin Alpha-1. But here's the key: Thymalin is broad-spectrum. It's like a full thymus “reset.” Thymogen is more targeted — especially for the “post-viral” use case, that lingering sickness, the recovery phase, or even as a proactive tool when colds and flus are making their rounds. And honestly, that's exactly why this episode matters right now, because I've been dealing with a little head cold myself after travel and lack of sleep.In this episode, I break down what Thymogen is (a synthetic dipeptide: L-glutamyl-L-tryptophan), why it's interesting from a longevity perspective, and what we know about its safety history in Russia. Then we get into the mechanisms: T-cell maturation, immune surveillance, neutrophil function, and even some of the signaling pathways it appears to influence like ERK, mTOR-related proteins, STAT1, and chromatin remodeling. I also explain why I see Thymogen as more of an immune modulator than a blunt “stimulator,” which matters a lot if you're dealing with inflammation or an overactive immune system.We'll talk practical benefits — fewer infections, better recovery, inflammation control, and why the animal data is intriguing when you look at lifespan and tumor incidence. Then I'll give you my straightforward protocol: 1–2 mg per day for 30–60 days, usually once or twice per year as a tune-up… and also how I'd deploy it if you're actively sick or dealing with something that just won't clear.Finally, I'll compare Thymogen vs Thymalin, and I'll explain how you can use them together: Thymalin as the foundation, Thymogen as the fine-tuning. And I'll even touch on when I'd consider stacking them with Thymosin Alpha-1 if you're trying to cover every base for immune protection.Before we jump in — thank you. Seriously. As we wrap up 2025, I've been overwhelmed with gratitude for the messages from people telling me they're getting real results. I don't exist without you guys. Also make sure you're on the email list (link in the description) so we can stay connected no matter what happens on social platforms. And if you want direct access to me, live calls, and real-time feedback on your protocols, check out the Axion Collective — it's the community I'm putting everything into.

BONUS Episode:Das ist eine besondere Modern Medicine Episode. Es ist meine erste Folge auf Englisch und damit ein Gespräch, das dir direkte Einblicke in die internationale Longevity Forschung gibt.Ich hatte die Ehre mit Prof. Matt Kaeberlein zu sprechen, ein US amerikanischer Biologe und einer der prägenden Forscher im Bereich der molekularen Alterungsmechanismen.Wir sprechen darüber, wie sinnvoll gängige Tests zur Bestimmung des biologischen Alters wirklich sind, warum mTOR als zentraler Stoffwechsel Schalter Alterungsprozesse mitsteuert und wie Ernährung, Kalorienrestriktion und Proteinzufuhr diese Signalwege beeinflussen.In dieser Folge erfährst du:

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You'll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and nutrient sensing interact to determine biological age, disease risk, and long term human performance. This is not surface level biohacking. It is a deep dive into the mechanisms that actually control aging, metabolism, muscle preservation, and brain optimization, and why most anti aging strategies fail when they ignore these foundations. This all-time classic episode from 2024, has host Dave Asprey joined by Mark Hyman, a practicing physician and one of the most respected leaders in functional medicine. Dr. Hyman is the founder and senior advisor of The UltraWellnessCenter, the founder and former head of strategy and innovation at the Cleveland Clinic Center for Functional Medicine, and a long time advocate for treating root causes instead of managing disease. With over 30 years of clinical experience, his work focuses on restoring mitochondrial health, optimizing metabolism, reversing chronic disease, and slowing biological aging using science backed interventions. Together, Dave and Mark dismantle common myths around protein, carnivore diets, ketosis, fasting, supplements, and longevity drugs. They explain why sugar accelerates aging faster than protein, how mTOR must cycle instead of staying suppressed, and why muscle, mitochondria, and metabolic flexibility matter more than calorie restriction. The conversation also covers nootropics, sleep optimization, neuroplasticity, AI driven diagnostics, and how functional medicine reframes aging as a reversible biological process rather than an inevitable decline. You'll learn: • How insulin and nutrient sensing control aging speed • Why mitochondria sit at the center of longevity and disease • The truth about mTOR, fasting, and protein intake • How ketosis and metabolic flexibility protect long term health • Where supplements and nootropics actually fit in brain optimization • Why functional medicine outperforms symptom based care • How AI and advanced testing are reshaping modern medicine Thank you to our sponsors! - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -OneSkin | Try OneSkin for 15% off with code DAVE at https://www.oneskin.co/DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity biohacking, functional medicine longevity, biological age reversal, mitochondria and aging, mTOR pathway aging, insulin resistance and aging, metabolic flexibility, fasting and longevity, ketosis and metabolism, protein intake and mTOR, muscle and longevity, inflammaging, chronic inflammation aging, mitochondrial dysfunction, nutrient sensing pathways, rapamycin longevity, metformin longevity debate, carnivore diet longevity, sugar and aging, brain optimization longevity, neuroplasticity and aging, sleep optimization biohacking, supplements for longevity, anti aging metabolism, human performance optimization, Dave Asprey longevity, Mark Hyman longevity Resources: • Mark's Website: https://drhyman.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction 4:49 - Aging as a Treatable Disease 7:50 - The Hallmarks of Aging 14:23 - Nutrient Sensing and Longevity Switches 17:37 - Time Restricted Eating and Autophagy 20:44 - The Four Longevity Pathways 21:49 - Metformin Debate 25:30 - Ozempic and Weight Loss 28:42 - Rapamycin and mTOR 36:23 - Meat, Protein, and Aging 39:46 - Protein Quality and Muscle Synthesis 45:50 - Protein Timing for Muscle Building 48:08 - Metabolic Flexibility 51:32 - Inflammaging 55:26 - Zombie Cells and Senescence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Omnia Performance Podcast, Fergus Crawley and Dr. Phil Price cut through the noise on concurrent training's interference effect. They unpack the science - from AMPK vs. mTOR signaling to why your training history matters - and deliver practical programming strategies for hybrid athletes. The bottom line? You can't optimize everything at once. Smart training means strategically consolidating stress and accepting the right compromises. Join The Wintering Training Plans and CoachingBook your FREE consultation callHybrid Training Guide (100% FREE)

Audio version of a White Board Series to help explain the content of the podcast.Here: https://youtu.be/wCWOM5Dyp2kShorts:https://youtu.be/G5I63MIC8OEhttps://youtu.be/9ZRk8aTGVVohttps://youtu.be/rcmSDgsylV8https://youtu.be/rcmSDgsylV8Episodes:https://youtu.be/gZdg9bX3Nuw?si=-WaqGnkF_xDXXbg8 https://youtu.be/ZPkb1Fp7EIc?si=5vP5z5ZnkycJcFFNhttps://youtu.be/wzqRFmHCdlM?si=No8JAquAkqTXlOyqhttps://youtu.be/1E53ZYehUCU?si=tGE4YQHmi08sOmfkhttps://youtu.be/NOVp4mIroug?si=Ys6ZJF9Gvnv83_tSDaylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autismFig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com00:00 Autistic Phenotype Core: Central, Peripheral, Enteric Nervous Systems03:40 Neurulation Introduction, Embryogenesis Recap, Neuroplate Formation07:20 Sonic Hedgehog Role, Proliferation, Motor/Interneurons, Thalamic Reticular Nucleus11:00 PTEN Pathway, mTOR, PIP Lipids, Cell Growth/Differentiation14:40 MTHFR (B9/Folate), Leukovorin, Methionine/Tryptophan Links18:20 Tryptophan as Aromatic Amino Acid, Maternal Serotonin, Neurite Overgrowth22:00 Brain Subdivision: Prosencephalon, Mesencephalon, Rhombencephalon Development26:00 Mesencephalon Anatomy: Substantia Nigra, Red Nucleus, Superior & Inferior Colliculi, Cranial Nerves30:00 Mesencephalon Functions: Motor Control, Sensory Integration, Attention Orienting, Autistic Phenotype TiesX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Exploring the Microbiome and Longevity with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist. He details the pivotal role of the gut in chronic disease, referencing the ancient insights of Hippocrates, and explores the concept of postbiotics. The conversation touches on the influence of gut health on various organ systems, the importance of diversity in the gut microbiome, and how lifestyle choices like diet, exercise, and sleep contribute to healthy aging. They also tackle cutting-edge topics such as the implications of GLP-1 medications, anabolic resistance, and the potential benefits of rapamycin for longevity.

Dr. Hoffman continues his conversation with Dr. Ross Pelton, Director of Science & Education for Essential Formulas Inc., which specializes in premium probiotic products. He's known as the Natural Pharmacist. 

In this episode, Dr. Jones is joined by Dr. Donald Layman, one of the world's top experts in protein metabolism. They discuss what happens to our muscles as we age, why leucine is a key amino acid for building and repairing muscle, and the amount of protein needed to stay strong and healthy.Dr. Layman also explains the differences between lifespan, longevity, and health span — and how muscle helps us stay active and independent as we age. You'll hear why muscle supports recovery from illness or injury, and why it's essential to protect it long before we reach old age.You'll learn why breakfast protein matters most, how to avoid age-related muscle loss, and what the research says about protein and kidney health, cancer risk, and living better for longer. This is your crash course in eating for muscle and aging better.

Are you doing all the right things—clean eating, daily workouts, supplements—yet feeling tired, inflamed, or stuck in a midlife plateau? On today's deep-dive episode of The Coach Debbie Potts Show, we unravel the hidden biology behind slow metabolism, stubborn fat gain, chronic fatigue, and the loss of muscle as we age. Coach Debbie Potts—FDN-P, FNTP, NASM-CPT, and certified PNOĒ Metabolic Analyst—guides you through the interconnected systems that determine how you age, burn fat, build muscle, and generate energy from the inside out. This is not your typical "eat less, move more" conversation. This is FutureYou Biology—the science of rebuilding metabolism, rewiring resilience, and restoring cellular safety so you can thrive, not struggle, in midlife. In This Episode, You'll Learn: PNOĒ Metabolic Testing — Your Real-Time Metabolic Blueprint How RER, VO₂ Max, FatMax, and ventilatory efficiency reveal whether your metabolism is stuck in sugar-burning mode or capable of efficient, flexible fat oxidation. AMPK — The Fat-Burning, Repair, and Longevity Switch Why Zone 2, fasting windows, cold exposure, and specific nutrients activate AMPK to improve mitochondria, reduce inflammation, and enhance metabolic flexibility. The Cell Danger Response (CDR) — When Mitochondria Hit the Brakes Based on Dr. Robert Naviaux's research, we explore why chronic stress, toxins, infections, or trauma push your mitochondria into "protection mode"—slowing metabolism, lowering energy, and blocking fat loss. The Vagus Nerve — The Hidden Root of Weight Loss Resistance If your nervous system doesn't feel safe, your metabolism won't unlock. Learn how vagal tone affects digestion, hormones, inflammation, and fat-burning—and how to train the vagus for better metabolic outcomes. mTOR + Protein After 40 — How to Rebuild Muscle & Strength Why women and men after 40 need higher protein, targeted leucine, and heavy strength training to overcome anabolic resistance and maintain metabolic rate and longevity. Cortisol, Hormones & Aging The stress-metabolism connection: how elevated cortisol suppresses thyroid function, blocks fat burning, and accelerates aging—and how to fix the rhythm. The FutureYou™ Formula How AMPK, mTOR, the vagus nerve, and mitochondrial health integrate into a personalized, test-not-guess blueprint for metabolic harmony. Featured Framework: FutureYou™ Meal Method Protein-forward, leucine-optimized meals to turn on muscle protein synthesis, maintain metabolic health, and improve fat-burning—especially for midlife women and men. "Protein is the ignition switch for metabolism. Leucine is the spark plug." — Coach Debbie Takeaway Aging well isn't luck—it's strategy. When you retrain metabolism, restore cellular safety, and rebuild vagal resilience, your body becomes capable of fat-burning, muscle building, and long-lasting energy again. It's time to rewrite your midlife biology and create your FutureYou. Work With Coach Debbie Ready to stop guessing and start testing? Book your PNOĒ Metabolic Test or schedule a discovery call at:

BUFFALO, NY — December 3, 2025 — A new #essay was #published in Volume 17, Issue 11 of Aging-US on November 19, 2025, titled “On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. Blagosklonny.” In this work, Aleksei G. Golubev from the N.N. Petrov National Medical Research Center of Oncology reflects on the legacy of two influential Russian scientists, Vladimir M. Dilman and his son Mikhail V. Blagosklonny, who each introduced groundbreaking ideas about aging and cancer. Drawing from his own experience working in Dilman's lab, Golubev explores how their ideas remain deeply relevant to today's scientific understanding. The essay connects Dilman's “elevation theory” with Blagosklonny's “hyperfunction theory,” two frameworks that challenge the conventional view of aging as a process of decline. Instead, both propose that aging results from continued biological processes that once supported growth but eventually become harmful when left unchecked. Dilman believed that aging begins with reduced sensitivity in the hypothalamus, a brain region that regulates the body's balance. This desensitization disrupts metabolism and hormone levels, setting the stage for many chronic illnesses. Decades later, Blagosklonny expanded on this idea at the molecular level. Central to his theory is the mTOR protein complex, which regulates growth and metabolism and is now a major focus in aging research. Golubev also explores the historical and personal connections between the two scientists. Dilman, an endocrinologist trained in the Soviet Union, and Blagosklonny, a molecular biologist educated during the post-Soviet period, represent two generations shaped by a shared scientific tradition. “Dilman's scientific legacy is not as well recognized as it should be, partly due to bias in citation practices.” The essay also draws attention to a troubling trend in science: the tendency to overlook early contributions, especially from non-Western scholars. Many of Dilman's insights, such as the connection between high blood sugar, insulin resistance, and cancer, have since been validated by modern tools, yet his work is rarely cited. Golubev points out how citation practices, language barriers, and historical isolation have contributed to this lack of recognition. Finally, Golubev encourages the scientific community to look back and acknowledge the foundational work that shaped modern aging science. It also highlights the importance of cross-generational knowledge in moving science forward. By tracing the intellectual journey from hormonal regulation in the brain to molecular pathways in cells, this essay demonstrated the relevance of old ideas in a new biological era. DOI - https://doi.org/10.18632/aging.206338 Corresponding author - Aleksei G. Golubev - lxglbv@rambler.ru Abstract video - https://www.youtube.com/watch?v=LvrdghTKGws Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206338 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, gerontology, history of science, hyperfunction, mTOR, hypothalamus, cancer, metabolism, immunity To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR.In this episode, we discuss:• The ambitious Million Molecule Challenge and why it could revolutionize the field.• Surprising discoveries already made, including molecules that outperform rapamycin.• Ora's strategic pivot to radiation resistance, with applications for astronauts, pilots, and human health.• How their data-driven approach is uncovering interventions for resilience against toxins and other stresses.• The journey from worm models to potential clinical trials and what's next for the company.Learn how Ora is scaling drug discovery to tackle aging and age-related diseases.https://orabiomedical.com/https://x.com/OraBiomedical  / ora-biomedical-inc  This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps00:00 – Intro01:13 – Welcome & Disclosure02:40 – Ora Biomedical & the Longevity Mission04:04 – How the Wormbot Was Born06:43 – Matt's Perspective on the Wormbot09:22 – Automating Lifespan Experiments at Scale12:29 – The Million Molecule Challenge15:03 – Success Stories from the Challenge16:10 – A Better mTOR Inhibitor Than Rapamycin19:05 – Ora's Molecule Beats Rapamycin20:08 – 60% Lifespan Extension Discovery24:03 – Ivermectin & Surprising Findings24:55 – From Longevity to Anti-Parasite Drugs31:09 – Hot Take: Discovery vs. Mechanism35:22 – The Million Molecule Challenge Database40:45 – Radiation Resistance: A New Focus44:57 – Space Travel & Longevity Medicine49:18 – Testing Resilience to Toxins & Stress56:54 – What Thousands of Tests Reveal About Aging Pathways01:00:41 – False Positives vs. False Negatives in Screening01:04:45 – Skin Health & Anti-Aging Potential01:07:59 – What's Next for Ora BiomedicalDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

In this solo episode, the host discusses the effects of metformin, berberine, and dihydroberberine on exercise adaptation and longevity. While metformin is known for its longevity benefits and is popular in the biohacking community, it has been shown to significantly reduce exercise adaptations and VO2 max gains. Berberine, a supplement with similar effects to metformin, is easier to obtain but still has some negative effects on exercise and significant GI side effects. The episode introduces dihydroberberine (DHB), a compound with fewer GI issues and less impact on exercise adaptation, making it more suitable for athletes. The host explains the mechanisms behind these compounds, including their effects on AMPK and mTOR pathways, and offers practical advice on when to take DHB in relation to different types of exercise to maximize benefits and minimize drawbacks.     Links: Harvard longevity researcher known for NAD+ & aging research. Diabetes drug often discussed for longevity.Energy-sensing enzyme that promotes catabolic (fat-burning) pathways.   Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 00:14 "Metformin may blunt up to 50% of your VO₂ max gains — that's a massive hit for any athlete." 00:30 Metformin: the popular longevity drug 01:00 Berberine: the over-the-counter alternative 02:30 Understanding AMPK and mTOR 04:30 Metformin's mechanism and drawbacks 06:00 Berberine's mechanism and side effects 07:30 Dihydro berberine: the superior choice 10:30 DHB and exercise: timing and benefits 18:00 Comparing Metformin, berberine, and DHB — The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to  cutting through the noise and uncovering the most effective strategies for optimizing health,  longevity, and peak performance. This podcast dives deep into evidence-based approaches to  hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise  protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.   Beyond health science, we tackle the intersection of public health and politics, exposing how  policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect on social with Dr. Mike Hart: Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

Send us a textWe trace how a soil-derived drug led to the discovery of mTOR, why growth control sits at the core of aging biology, and where evidence ends for humans. Michael Hall's quiet breakthroughs explain fasting, autophagy, and rapamycin without the hype.To read more about this topic and for more science stories, visit our website swisinfo.ch. You can help other people to find our podcast by leaving us a five-star review.Journalist: Jessica Davis PlüssHost: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Cravings aren't just about weak will; they're biology doing exactly what billions of food dollars engineered them to do. We sit down with Sander Brus to unpack how sweetness hijacks reward circuits, why kids are showing up with adult metabolic diseases, and what happens when you flip the switch on sweet taste itself.Sander takes us from his diagnostics background into the heart of metabolic health, explaining how sweet taste receptors (T1R2/T1R3) live on the tongue and in the gut, where they act as glucose sensors. You'll hear how plant compounds like gymnemic acids can temporarily block those receptors, making soda taste like “nothing,” softening the dopamine surge, and even reducing post-meal glucose and insulin in some studies. We compare the behavioral punch of reducing perceived sweetness to the pharmacology of GLP‑1 agonists, and we dig into CGM experiments that show real-world spikes shrinking when sweetness is inhibited.We also zoom out to the food environment: why sugar is uniquely craved compared to seed oils or grains, how high fructose corn syrup supercharges palatability, and why noncaloric sweeteners may still nudge insulin through cephalic responses. Sander shares practical playbooks for using a mouth rinse to tame dessert triggers or a capsule 30 minutes before carb-heavy meals to blunt spikes. Along the way, we talk palate reset in 10–14 days, metabolic flexibility, insulin's role in aging pathways like mTOR, and the hope of nudging an industry to build foods that support healthspan rather than erode it.If you've ever wanted fewer cravings, steadier energy, and data-backed ways to quiet the glucose roller coaster, this conversation offers both science and tactics you can try today. Listen, share with someone navigating sugar struggles, and tell us your biggest craving scenario so we can tackle it in a future episode. And if you're finding value here, subscribe, leave a review, and help more people discover metabolic tools that actually work.https://nosuhealth.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

Part Two of my engaging chat with Dr. Sandeep Gupta as we delve into the world of longevity, exploring a multitude of strategies designed to extend not just lifespan but healthspan as well. From the basics of supplements to advanced therapies, Dr. Gupta details a comprehensive approach to living not only longer but better. What You'll Learn: Understanding Supplements and Lifestyle: Discover the intrinsic role supplements play as secondary to beneficial lifestyle habits, emphasising that no supplement can substitute a poor lifestyle. Intermittent Fasting and Diet Tips: Learn the benefits of intermittent fasting and the importance of balancing protein and fasting to optimise the mTOR pathway without over activating it. Advanced Interventions: Explore hormone replacement therapy's role in improving quality of life during menopause and andropausal stages, and how these therapies are evolving. Pharmaceutical Opportunities: Gain insights into the judicious use of medications such as semaglutide and manjaro for weight management and metabolic health. Heavy Metals and Detoxification: Understand the impacts of heavy metals in the body, how they can disrupt enzyme functions, and effective ways to manage and detoxify them. Challenges in Longevity Health: Recognise common anti-longevity habits, such as excessive alcohol consumption, and how they can hinder your overall quality of life. Key Takeaways: Supplements Can't Replace Lifestyle: Emphasising good sleep, stress management, and regular exercise as the foundation of good health. Dietary Balance is Crucial: The right balance between protein intake and fasting periods can prevent chronic activation of growth pathways detrimental to longevity. Hormonal Health is Vital: Balanced hormone levels play a crucial role in longevity and quality of life, particularly as we age. Innovative Medications: Certain medications, carefully selected and used, can support weight management and metabolic health, crucial elements in longevity. Impact of Toxins: Regular detoxification and maintaining mineral balance effectively counteract heavy metal toxicity, enhancing longevity prospects. Live Mindfully: Reducing alcohol intake and focusing on holistic happiness can profoundly impact longevity and overall health. Resources To delve deeper into integrative health approaches and longevity practices, consider exploring resources and studies on metabolic syndrome, holistic care interventions, and the benefits of nature exposure. Engage with Dr. Sandeep Gupta About Sandeep: https://linktr.ee/drsandeepgupta Clinic: https://www.lotusholisticmedicine.com.au/dr-sandeep-gupta/ https://www.facebook.com/drsgupta/ https://www.linkedin.com/in/drsandeepgupta/ https://www.instagram.com/drsandeepgupta/?hl=en https://www.youtube.com/c/drsandeepgupta https://x.com/drsandeepgupta Support the Podcast If you found this conversation valuable, consider subscribing and leaving a review on your preferred podcast platform. Your feedback helps us continue to bring you insightful discussions on important health topics. Join the conversation on living a vibrant, balanced life, rich in health and vitality that allows you to enjoy more years of joyful living. Share this episode with someone who might benefit from these insights—because understanding integrative health can make all the difference. 00:00 Introduction to Supplements and Longevity 00:44 The Role of Lifestyle in Longevity 03:05 Intermittent Fasting and Its Benefits 03:59 Balancing Protein and mTOR Pathway 06:24 Practical Tips for Intermittent Fasting 11:02 Advanced Interventions: Hormone Therapy 16:11 Bioidentical Hormone Replacement Therapy 22:07 The Impact of Hormones on Mental Health 23:07 Exploring Pharmaceutical Interventions 23:45 Understanding Cardiovascular Health 28:05 Metabolic Health and Weight Loss Drugs 33:54 Mitochondrial Support and NAD 38:40 Heavy Metals and Detoxification 42:34 Biggest Anti-Longevity HabitSee omnystudio.com/listener for privacy information.

In this special Q&A episode, Dr. Jason Fung joins TFM Coach Lisa and Community Mentor Patrice Michael to revisit The Cancer Code — five years after its release. Together, they explore how modern science is reframing cancer not as a disease of random genetic "bad luck," but as an evolutionary and metabolic condition deeply connected to insulin, diet, and lifestyle. Dr. Fung explains how hyperinsulinemia, obesity, and processed foods create fertile "soil" for cancer to grow — and how fasting and nutritional strategies can help restore metabolic balance. He also discusses the link between hormones and cancer risk, new non-radiation screening technologies, and how combining traditional treatments with metabolic interventions may shape the future of cancer care.

Do you ever feel like you're drowning in health advice that contradicts itself — and none of it seems to work anymore in midlife? Today, I'm joined by Jenn Trepeck, health coach and host of the Salad With a Side of Fries podcast, to talk about her brand-new book "Uncomplicating Wellness." We cover: Why midlife health gets so confusing and how outdated strategies fail us once estrogen declines The 6 pillars of her Bio Stack The secret power of Wellness Anchors: small daily habits that keep you grounded How to replace all-or-nothing thinking with a "progress over perfection" mindset The protein debate: mTOR and longevity vs muscle and strength   Jenn Trepeck is an Optimal Health Coach, award-winning podcast host of Salad with a Side of Fries, and author of Uncomplicating Wellness: 6 Simple Steps to Your Healthiest You. Her podcast has become a top-ranked health and wellness show, known for its blend of science-backed education and real-world humor. Jenn's philosophy - "wellness without the weirdness"- runs through everything she does, encouraging people to enjoy their food, understand their bodies, and make choices that feel sustainable. Book: Uncomplicating wellness https://asaladwithasideoffries.com/uncomplicating-wellness/ Group & 1:1 coaching - start with a complimentary curiosity call : https://asaladwithasideoffries.com/contact/ RHONDA PATRICK EPISODE ON PROTEIN: https://youtu.be/fvO8e-2y37k?si=pua3hgZcy2uIAgNR Contact Jenn Trepeck Website: https://asaladwithasideoffries.com/  Instagram: https://www.instagram.com/saladwithasideoffriespod/  Facebook: https://www.facebook.com/Saladwithasideoffriespodcast  Facebook group://m.facebook.com/groups/425796548337541/  LinkedIn: https://www.linkedin.com/in/jennifertrepeck/  YouTube: www.youtube.com/@jenntrepeck  Tik Tok: https://www.tiktok.com/@jenntrepeck  Podcast: https://asaladwithasideoffries.com/a-salad-with-a-side-of-fries/#latest-episodes Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here - https://vitaliskincare.com Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - http://oxfordhealthspan.com/discount/ZORA Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com - https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠     Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠   Biohacking Menopause Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠    For partnership inquiries: https://www.category3.ca/  Some episodes of Hack My Age are supported by partners whose products or services may be discussed during the show. The host may receive compensation or earn a minor commission if you purchase through affiliate links at no extra cost to you. All opinions shared are those of the host and guests, based on personal experience and research, and do not necessarily represent the views of any sponsor. Sponsorships do not imply medical endorsement or approval by any healthcare provider featured on this podcast.  

Feeling stuck on your midlife health journey? Set-up your free coaching session today: https://www.erintrier.com/coaching.In this episode, we explore the deeper layers of metabolic health, moving beyond the old narrative of weight management and calories in/calories out to uncover what's really happening inside the body. It's all about ENERGY and how our metabolism drives overall cellular function.I break down how our energy pathways (mTOR and AMPK) work, why nutrition and recovery are key to balance and how midlife hormonal shifts play a major role in our metabolism.This conversation is a guide for women ready to understand their physiology, reconnect with their energy and learn how to support their bodies through every season of life.Tune in to learn more about:- Metabolic health and how the body produces, stores and uses energy.- How hormonal changes in midlife deeply influence metabolism.- How the endocrine system is interconnected and no system functions alone.- Understanding the difference between mTOR (growth/build) and AMPK (repair/restore) energy pathways.Listen to today's message to better understand your body on a deeper level and discover how to optimize your energy from the inside out.Podcast mentioned about SYNC and the four legged chair: https://podcasts.apple.com/us/podcast/empowered-in-health/id1598678571?i=1000617139213If this episode resonated with you, please subscribe and leave a review on your favorite podcast platform. Sharing this episode with a friend can also help us reach more incredible women on their journey to better health.Thank you for being a part of our community and investing in your wellness journey!To stay connected, here's where you can find me online:Podcast IG: https://www.instagram.com/empoweredinhealth Coaching Business IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/erinktrier Book Free Coaching Call Here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.erintrier.com/coachingWebsite: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.erintrier.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (0:00) David Sinclair (0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of Aging; Epigenome & Genes (4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes (6:44) Physical Appearance & Aging (7:36) Sponsor: David (8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging (11:30) Rates of Puberty & Aging, Growth Hormone (12:37) Body Size & Longevity; Epigenetics (13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07) Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions (27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight Sleep (31:10) Iron & Senescent Cells; Personalize Medicine (32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic & Resistance Exercise (35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation (38:20) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Stell Dir vor, Du fährst seit Jahren mit angezogener Handbremse – und merkst es nicht mal. Genau das passiert gerade Millionen Menschen. Nicht mit dem Auto, sondern mit ihrem Körper.Der Grund? Eine winzige Zahl, die seit Jahrzehnten in Ernährungsrichtlinien steht: 0,8 Gramm Protein pro Kilo Körpergewicht. Das Problem: Diese Empfehlung wurde entwickelt, damit Du überlebst – nicht, damit Du gedeihen kannst.In dieser Folge erfährst Du:Warum die offiziellen Protein-Empfehlungen für aktive Menschen völlig unzureichend sind (und wie viel Du wirklich brauchst)Was Sarkopenie ist und warum sie schon ab 30 beginnt – und wie Protein Deine Versicherung gegen die „Disability-Schwelle“ istDie brutale Wahrheit über Proteinmangel: Warum der Durchschnitts-Esser jeden Tag 24 g zu wenig isst (und was das über Jahre bedeutet)Nieren, Krebs, mTOR: Alle wissenschaftlichen Antworten auf die heißesten Protein-Kontroversen5 konkrete Strategien, wie Du genug Protein mühelos in Deinen Alltag integrierstAm Ende der Folge weißt Du genau, wie viel Protein DU benötigst – und warum es eine der einfachsten Stellschrauben für ein starkes, gesundes Leben ist.Spoiler: Es sind nicht 0,8 Gramm. Es sind mindestens doppelt so viel.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Marks neues Buch:Looking Good Naked: Die GesamtausgabeErwähnte Tools & Apps:Yazio Pro – Ernährungs-Tracking-App (von Mark genutzt)Erwähnte Experten & Interviews:Dr. Peter Attia – Podcast-Interview mit Luke Van Loon (2024) über Proteinbedarf und Sarkopenie, Interview-Serie über Protein (2025) Teil 1, Teil 2Luke Van Loon – Proteinforscher, Konzept der „Disability-Schwelle“David Allison – Adipositas-Forscher, „Überleben vs. Gedeihen“-Konzept + LinkedIn-Post zu Protein-SicherheitDr. Rhonda Patrick – Ernährungsforscherin, mTOR und Studienbedingungen bei MäusenDr. Malte Rubach – Ernährungswissenschaftler (Folge #499 bei Fitness mit M.A.R.K.)Wissenschaftliche Konzepte (im Podcast erklärt):Stickstoffbilanzstudien (1950er/60er)Aminosäurenoxidation (moderne Messmethode)Sarkopenie und anabole ResistenzmTOR-Signalweg und LeucinGLP-1-Agonisten (Ozempic, Wegovy)LiteraturverzeichnisEine Übersicht der zugrunde liegenden wissenschaftlichen Studien findest Du hier.____________Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

Are you feeling stuck, inflamed, or frustrated that nothing seems to work anymore — even the so-called “miracle” GLP-1 medications? In this episode, Coach Debbie Potts explains why your metabolism probably isn't broken… it's misunderstood. Discover how PNOĒ Metabolic Testing and a Functional Health Investigation can reveal what's really driving your fatigue, weight gain, and burnout — and how to rebuild your metabolism naturally through The WHOLESTIC Method™ and your personalized FutureYou plan. You'll learn: What your breath can reveal about fat vs. carb metabolism How the Cell Danger Response shuts down energy production Why mitochondrial health is the key to longevity and vitality How sympathetic dominance and poor vagal tone block fat loss The balance between AMPK and mTOR for optimal aging Why VO₂ Max is one of the best predictors of longevity How to rebuild your health from the inside out — starting with drainage, detox, and nervous-system repair Why you can't out-supplement poor lifestyle habits or out-exercise a poor diet Debbie also shares how her clients use testing, not guessing, to identify their personal metabolic roadblocks — and how stacking consistent “base hits” with the Eight Elements of The WHOLESTIC Method™ leads to long-term transformation. Because aging isn't the enemy — unawareness is. ✨ Test your metabolism. Rebuild your energy. Redefine your Future You.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Rhonda Patrick is a scientist, health educator, and host of the FoundMyFitness podcast whose work explores the intersection of nutrition, aging, and disease prevention. In this episode, Rhonda joins Peter for part two of his deep dive on protein, continuing last week's discussion with David Allison and expanding the conversation to include creatine supplementation and sauna use. She discusses why the current RDA for protein is insufficient, how much more is needed to maintain muscle mass and prevent frailty, how activity level and aging influence protein requirements through mechanisms such as anabolic resistance, and how to determine optimal protein intake. The conversation also covers creatine's proven effects on strength, endurance, and performance; its overlooked benefits for cognition and brain health; and the optimal dosing for different populations. Rhonda closes with the science behind sauna use, including its cardiovascular and cognitive benefits, the role of heat shock proteins, and practical guidance on temperature and duration. We discuss: Why the current protein RDA is too low, and why maintaining sufficient amino acid intake is vital for muscle preservation and health [3:30]; The case for raising the protein RDA by at least 50% [9:45]; Anabolic resistance: why inactivity—more than aging—blunts the body's response to protein, and how resistance training restores it [14:00]; How sarcopenia develops, the profound effect of frailty on quality of life, and why it's crucial to build and maintain muscle early [20:00]; Finding the optimal protein dose [25:00]; Why aiming higher is smarter: the case for targeting 2g of protein per kg of body weight in the real world [32:15]; Protein needs for pregnant women and growing adolescents [37:30]; Why higher protein intake is crucial when trying to lose fat while preserving or gaining muscle [39:45]; GLP-1 drugs: protein needs, muscle preservation, dosing strategies, evidence of broader health impacts, and more [43:45]; How overweight individuals should calculate protein needs based on target body weight [50:45]; Unpacking a misunderstood topic: the relationship between protein intake, mTOR activation, and longevity [52:00]; Why it's unclear whether rapamycin is geroprotective in humans, and how misinterpreted animal data have fueled misconceptions about protein or mTOR activation being harmful [1:00:45]; The unmatched longevity benefits of exercise, its synergy with higher protein intake, and Peter's recommended protein intake [1:06:15]; How Rhonda became fascinated with creatine—a well-studied, safe, and effective supplement for improving exercise performance [1:09:00]; Creatine for the brain: how higher doses may enhance cognition under stress and support resilience against aging and disease [1:16:30]; Optimal creatine use: dosing for adults and teens, safe product selection, debunking kidney myths, and more [1:25:45]; Sauna: how deliberate heat exposure mimics exercise, boosts cardiovascular and brain health, and shows promise for improving mood and mental resilience [1:32:15]; The benefits of sauna for reducing risk of dementia, and why hotter may not be better [1:41:15]; The FoundMyFitness podcast [1:45:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this month's Fertility & Sterility: Unplugged, we take a look at articles from F&S's sister journals! Topics this month include: circadian rhythm and reproductive health (04:34), fertility treatment outcomes after bariatric surgery (13:49), interleukin-22 balance and pregnancy (26:35), and mTOR inhibitors for fertility preservation in breast cancer (39:45). Consider This: https://www.fertstert.org/news-do/chronofertility-integrating-multi-timescale-chronobiology-into-fertility-research-and F&S Reports: https://www.fertstertreports.org/article/S2666-3341(25)00097-2/fulltext F&S Science: https://www.fertstertscience.org/article/S2666-335X(25)00065-5/fulltext F&S Reviews: https://www.fertstertreviews.org/article/S2666-5719(25)00011-8/abstract View the sister journals at: https://www.fertstertreviews.org https://www.fertstertreports.org https://www.fertstertscience.org

Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You'll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alberto Villoldo, Ph.D.—medical anthropologist, neuroscientist, energy medicine pioneer, and founder of The Four Winds Society, the gold-standard school for modern shamans. He has spent 25+ years studying Amazonian and Andean healing traditions, led the Biological Self-Regulation Lab at San Francisco State University to explore psychosomatic medicine, and authored more than 25 bestselling books on neuroscience, functional medicine, and energy healing. Few people on earth bridge ancient biohacking and modern brain science at this level. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll learn: • How to grow a new brain every 22 days using neuroplasticity and mitochondria support • Why plant medicines and NRF2 activators can turn on 1,100 healing genes in 24 hours • The surprising link between nootropics, psychedelics, serotonin, and endogenous DMT • How mindset, belief systems, and placebo/nocebo shape immune function and metabolism • Why RFK's chronic disease warning connects to viral evolution and immune collapse • The real reason carnivore diets work—and when they fail without gut repair • Peptides, GLP-1 agonists, and the future of functional medicine hacking • Why most people sabotage themselves and how to stop fighting your own biology This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NRF2 activation, Neurogenesis and hippocampus repair, Plant-based epigenetic triggers, Psychosomatic health, Serotonin to DMT conversion, Pineal gland methylation, Parasites and brain inflammation, Viral-driven evolution, GLP-1 agonists and longevity, Psilocybin lifespan extension, Autophagy and brain cleanup, Energetic medicine training, Functional peptides, BPC-157, Breathwork and CO2 tolerance, mTOR cycling, Cold exposure and dopamine, Mindset-driven immune function Thank you to our sponsors! • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. • Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. • Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. • fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Learn more from Alberto at: www.thefourwinds.com and www.albertovilloldo.net • Buy the book ‘Grow A New Brain': https://a.co/d/5lVhrVy • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction & Ayahuasca Story 3:15 — Shamanism Beyond Plant Medicine 6:53 — Losing Your Mind to Evolve 10:45 — The 22-Day New Brain Cycle 12:53 — Plant Communication & Direct Knowing 15:35 — Parasites, Liver Failure & Brain Damage 20:25 — Remote Healing & CIA Research 22:40 — Tryptophan, Turkey Farmers & Brain Chemistry 25:19 — Viruses as Evolutionary Drivers 30:30 — Psilocybin & Life Extension 35:25 — Healing with Mindset + Biology 38:52 — Spirit, Purpose & Growing Gods 43:49 — Plants, Protein & mTOR 49:07 — Training the Four Brains 51:16 — Cold Exposure: Pain vs Suffering 54:40 — Who Am I? Living the Question 55:25 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts. This episode covers: - Rapamycin's Reality Check: A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs. Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025 - Senolytics Get Precise: New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all. Source: Aging-US research stream – September 23, 2025 - AI Healthcare: Promise and Pause: The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain. Source: Crescendo.ai – September 23, 2025 - Medical Policy Meets Machine Logic: A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access. Source: KFF Health News policy rundown – September 25, 2025 - Longevity Headlines You Can Use: Forest bathing wins renewed praise for helping with blood pressure and stress. Northwestern's SuperAger project links strong social ties to resilient brain health. Human trials now test an antibody therapy to regrow lost teeth. Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025 Action steps for the week: Try fasting windows and smart protein clustering for mTOR modulation. Let AI help summarize your health data—but get decisions confirmed by your clinician. If you or your family touch Medicare, keep thorough documentation and demand human review. Soak in green spaces, reconnect socially, and watch for cutting-edge therapies. All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:18 — Rapamycin Hype Check 1:07 — Senolytics Leveled Up 2:41 — AI in Healthcare 3:11 — AI Between You and Your Doctor 5:50 — Three Longevity Angles 7:59 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, I explore intermittent fasting and time-restricted eating, highlighting the positive benefits for weight loss, metabolism, organ health, circadian rhythms and cellular repair. I explain a practical framework for designing a time-restricted eating window that aligns with your lifestyle, exercise schedule and social schedule. I also cover what breaks a fast, how to support fasting with tools like salt intake and post-meal walks, and the use of fasting-related supplements, including berberine and metformin. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Carbon: https://joincarbon.com/huberman LMNT: https://drinklmnt.com/huberman Joovv: https://joovv.com/huberman Timestamps (00:00) Intermittent Fasting, Time-Restricted Eating (TRE) (00:50) Diet, Weight Loss, Calories & Hormones (05:50) Body's Response to Eating vs Fasting, Fasting Duration (09:04) Sponsor: Carbon (10:50) Time-Restricted Feeding & Metabolic Benefits, Circadian Gene Rhythm (16:19) Optimal Meal Timing, Tool: Extend Sleep-Related Fasts (21:29) Sponsors: AG1 & LMNT (24:02) Eating Window Length, Tools: Adjusting TRE for Building Muscle, Regularity (26:55) Accelerate Transition to Fasting, Glucose Clearing, Tool: After-Meal Walk (28:36) Metformin, Berberine, Continuous Glucose Monitors; Cell Growth vs Repair, mTOR (31:46) Gut Microbiome; Transitioning to Intermittent Fasting & Individualization (34:03) Tool: 8-Hour Feeding Window & Weight Loss (35:25) Sponsor: Joovv (36:40) What Breaks a Fast?, Sugar; Tool: Using Salt to Support Fasting (39:42) Tool: Ideal Feeding Window Guidelines; Exercise & Social Considerations Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Grab my FREE 4 Part Video Series: GLP1s Uncovered: https://bit.ly/GLP1uncovered EP 224: Today I'm diving into one of my greatest passions, coffee. Not just for the flavor or daily ritual, but because the science behind it is incredibly compelling. Often misunderstood and unfairly demonized in wellness circles, coffee is, in my view, one of the most powerful herbal medicines we have. Its benefits span brain health, metabolism, mood, cardiovascular support, and more. I'll break down the latest research on caffeine metabolism, including the key differences between slow and fast metabolizers, and how your individual response can impact sleep, blood pressure, and overall well-being. If you've ever questioned your relationship with coffee, or felt guilt-tripped into giving it up, this episode brings the data, context, and clarity you need to make your own informed choice. Check Out Kion Coffee - To save 20%, go to getkion.com/drtyna Topics Discussed: → Is coffee bad for your adrenal glands? → What are the health benefits of black coffee? → What's the difference between fast and slow caffeine metabolizers? → Does coffee improve metabolism and brain function? Sponsored By: → Check Out Kion Coffee - To save 20%, go to getkion.com/drtyna On This Episode We Cover:  → 00:00:00 - Introduction  → 00:08:01 - My go-to coffee order → 00:09:57 - Signs of slow caffeine metabolism → 00:13:01 - Ideal timing, dose, and nutrients → 00:18:11 - Heart, gut, and brain benefits → 00:24:36 - Mood, AMPK, and mTOR support → 00:26:40 - Adrenals, liver, and longevity → 00:29:52 - Metabolism and coffee → 00:31:39 - Research on aging and mortality → 00:35:51 - Why I choose Kion coffee → 00:39:27 - Coffee and mitochondrial health → 00:41:41 - Gut impact and inflammation → 00:44:31 - Dose-dependent effects → 00:48:28 - Filtered vs. unfiltered coffee → 00:50:36 - Mold & pesticides  Further Listening:  → Heart Health Playlist 

Getting 50 grams of protein per meal may be the single most underrated biohacking protein strategy for muscle growth, metabolism, and longevity. In this episode, you'll discover why animal protein vs vegan is not a fair match biologically, how hitting the leucine threshold activates mTOR for longevity, and why muscle is the most overlooked organ of aging. This is must-listen content for anyone optimizing human performance, hacking metabolism, or reversing muscle loss with food. Host Dave Asprey is joined by Dr. Gabrielle Lyon, a pioneer in Muscle-Centric Medicine®, functional medicine expert, and top authority on clinical nutrition for longevity. Trained by protein researcher Dr. Donald Layman, she brings decades of expertise on how to use high-protein diets, amino acid science, and functional medicine to radically improve healthspan and brain optimization. Dr. Lyon works with everyone from special operators to aging patients, making her one of the most trusted voices in anti-aging diet strategies. Watch this channel on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn: • Why 50g of protein per meal matters more than total daily intake • How mTOR and longevity are misunderstood in mainstream nutrition • Why protein vs plant protein debates ignore hard biological data • How leucine thresholds determine muscle activation • Why fasting and protein cycling beats low-protein veganism • How ketosis and protein intake impact metabolic health • Why many on a vegan diet experience sleep issues, hormone crashes, and reduced resilience • How functional medicine podcasts like this one reveal the truth about aging and muscle loss • What happens clinically when patients switch to a high-protein diet • How to use supplements, nootropics, and protein hacks to enhance neuroplasticity, mitochondrial energy, and total body performance If you've ever asked “what's the best protein for muscle growth?” or “how does protein affect metabolism in aging?”, this episode gives you evidence-based answers from the front lines of clinical nutrition. This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you're tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won't hear anywhere else. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! 40 Years of Zen | Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. Resources: • Gabrielle's Website: https://drgabriellelyon.com/ • Gabrielle's IG: https://www.instagram.com/drgabriellelyon/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 Trailer • 0:51 Protein Controversy • 2:38 Leucine • 6:00 mTOR, Methionine, and Protein Synthesis • 9:00 Vegan vs. Carnivore • 16:00 Optimizing Protein Intake & Aging • 22:00 Carbohydrates, Hormones, and Female Health • 28:00 Environmental Impact & Food Sourcing • 34:00 Debunking Plant-Based Documentaries • 40:00 Key Takeaways & Closing Keywords: protein vs plant protein, 50 grams of protein, biohacking protein, mTOR and longevity, animal protein vs vegan, leucine threshold, Gabrielle Lyon, muscle-centric medicine, best protein for muscle growth, anti-aging diet, muscle as organ of longevity, fasting and protein, ketosis and protein, vegan diet risks, optimizing metabolism, high-protein diet, functional medicine podcast, Dave Asprey protein, aging and muscle loss, clinical nutrition for longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from his discussions with Paul Turek and Paula Amato on male and female fertility; Rachel Rubin on menopause and hormone replacement therapy; Brian Kennedy on the biology of aging; Tanuj Nakra and Suzan Obagi on facial aging and skin rejuvenation; and BJ Miller and Bridget Sumser on lessons we can learn from the dying about how to live. Peter highlights the most important insights from each episode and any behavioral changes he's made for himself or his patients as a result of these fascinating discussions. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #358 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Summary of episode topics [1:15]; Episodes on fertility with Paul Turek and Paula Amato: insights on all things male and female fertility [4:45]; How men can optimize fertility [20:15]; How women can optimize fertility [26:00]; Rachel Rubin episode: insights on women's sexual health, menopause, and HRT [31:45]; How women can prepare for menopause: proactive care, evidence-based HRT, and more [41:45]; Brian Kennedy episode: understanding aging, role of inflammation and mTOR, and current limitations of aging clocks and biomarkers [46:30]; Advice from Brian Kennedy on testing longevity interventions [56:45]; Tanuj Nakra/Suzan Obagi episode: causes of facial aging and practical strategies for prevention and treatment [57:30]; Skincare: making sense of the wide range of skin resurfacing treatments [1:06:45]; How to create a realistic, sustainable skincare routine [1:12:30]; The dangers of following unqualified aesthetic advice online and the importance of getting professional medical guidance for cosmetic treatments [1:18:00]; BJ Miller/Bridget Sumser episode: lessons about living from the dying [1:21:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, and director of the Center for Healthy Longevity at the National University of Singapore. In this episode, Brian shares insights from ongoing human aging studies, including clinical trials of rapamycin and how dosing strategies, timing, and exercise may influence outcomes. He presents two key models of aging—one as a linear accumulation of biological decline and the other as an exponential rise in mortality risk—and explains why traditional models of aging fall short. He also explains why most current aging biomarkers lack clinical utility and describes how his team is working to develop a more actionable biological clock. Additional topics include the potential of compounds like alpha-ketoglutarate, urolithin A, and NAD boosters, along with how lifestyle interventions—such as VO2 max training, strength building, and the use of GLP-1 and SGLT2 drugs—may contribute to longer, healthier lives. We discuss: Brian's journey from the Buck Institute to Singapore, and the global evolution of aging research [2:45]; Rethinking the biology of aging: why models like the hallmarks of aging fall short [9:45]; How inflammation and mTOR signaling may play a central, causal role in aging [14:15]; The biological role of mTOR in aging, and the potential of rapamycin to slow aging and enhance immune resilience [17:30]; Aging as a linear decline in resilience overlaid with non-linear health fluctuations [22:30]; Speculating on the future of longevity: slowing biological aging through noise reduction and reprogramming [33:30]; Evaluating the role of the epigenome in aging, and the limits of methylation clocks [39:00]; Balancing the quest for immortality with the urgent need to improve late-life healthspan [43:00]; Comparing the big 4 chronic diseases: which are the most inevitable and modifiable? [47:15]; Exploring potential benefits of rapamycin: how Brian is testing this and other interventions in humans [51:45]; Testing alpha-ketoglutarate (AKG) for healthspan benefits in aging [1:01:45]; Exploring urolithin A's potential to enhance mitochondrial health, reduce frailty, and slow aging [1:05:30]; The potential of sublingual NAD for longevity, and the combination of NAD and AKG for metabolic and exercise enhancement [1:09:00]; Other interventions that may promote longevity: spermidine, 17