Podcasts about Thursday Night Football

On this episode of Tiger-Cats Game Day, hosts Louie B and Mike Daly get you set for the Hamilton Tiger-Cats first road matchup of the season when they travel to Winnipeg to take on the Winnipeg Blue Bombers in Thursday Night Football.

A dominant nine-goal first quarter from the Crows took the bite and the bark from the Dogs in a cruisy 57-point win on Thursday Night Football.See omnystudio.com/listener for privacy information.

Microplastics and Stroke Risk: What a Landmark 2024 Study Found Inside Human Arteries In 2024, a team of Italian researchers published a study in the New England Journal of Medicine that stopped the cardiovascular science community in its tracks. They found microplastics, tiny synthetic fragments embedded inside the carotid artery plaque of more than half the patients they examined. And the patients who had them faced more than four and a half times the risk of a serious cardiovascular event compared to those who didn’t. This isn’t a distant, theoretical risk. These are living people who had already been identified as having carotid artery disease, and plastics were found inside their arterial walls. For stroke survivors and those at elevated risk of stroke, this study raises important questions that the medical system has not yet caught up with. What the Research Found The study by Marfella et al., published in the New England Journal of Medicine (2024), enrolled 304 patients who were undergoing carotid endarterectomy, a surgical procedure to remove plaque from the carotid arteries. Researchers analysed the excised plaque for the presence of microplastics and nanoplastics. Their findings: 58% of patients had detectable levels of polyethylene, polyvinyl chloride (PVC), or polystyrene in their arterial plaque. This was not contamination from the surgical procedure; it was already there. Over a 34-month follow-up period, patients with microplastics in their plaque had a 4.53 times higher risk of a combined endpoint: non-fatal myocardial infarction, non-fatal stroke, or death from any cause. Inflammatory markers were significantly elevated in the microplastics-positive group. IL-18 and TNF-alpha proteins associated with systemic vascular inflammation were markedly higher in plaque samples that contained plastics. This suggests the mechanism is not simply physical obstruction, but an inflammatory cascade triggered by the presence of synthetic material in arterial tissue. What This Means for Stroke Survivors The carotid arteries are the primary conduits supplying oxygenated blood to the brain. Plaque accumulation in these vessels is one of the leading causes of ischaemic stroke, and carotid artery disease is a condition many stroke survivors are already living with. “The patients with microplastics in their plaque had a 4.53 times higher risk of stroke, heart attack, or death over the 34-month follow-up. That’s not a marginal finding. That’s a signal the research community needed to take seriously.” The NEJM study doesn’t yet tell us whether removing microplastic exposure after the fact reduces risk. It doesn’t confirm that healthy individuals with no existing carotid disease are accumulating plastics at the same rate. And it cannot tell us which plastic sources are most responsible because we’re exposed to microplastics through drinking water, food packaging, air, and a dozen other vectors simultaneously. But what it does tell us clearly and with high statistical significance is that microplastics in arterial plaque are associated with dramatically worse cardiovascular outcomes. What the Research Does Not Yet Tell Us Science at the frontier moves in one direction at a time. This study establishes association, not causation. It cannot yet answer: Whether people without existing carotid disease are accumulating microplastics at comparable rates. Whether reducing exposure actively reverses or slows plaque-associated risk. Which types of microplastics are most biologically harmful? Whether there will be a clinical screening tool for this in the near future. These are the questions the next generation of research will need to answer. In the meantime, it’s reasonable to act on what we do know. Practical Steps to Reduce Exposure No clinical screening currently exists for microplastics in arterial plaque. There is no blood test, no imaging, no biomarker that your GP can order today. What you can do is reduce your ongoing exposure, particularly through food and water contact with plastics. Evidence-informed steps worth discussing with your treating team: Use glass, stainless steel, or ceramic containers rather than plastic for food and drink storage. Avoid microwaving food in plastic containers; heat accelerates the leaching of plastic particles. Filter your drinking water; some filters (carbon block and reverse osmosis) reduce microplastic levels significantly. Reduce consumption of highly processed foods in plastic packaging. Bring this study to your vascular neurologist, cardiologist, or GP and ask whether it’s relevant to your personal risk profile. This is not a recommendation to take a supplement or start a treatment. It’s an invitation to have an informed conversation with the people responsible for your care using the best available evidence. If you found this useful, my book walks through the science of stroke recovery in the same evidence-first, no-hype way. Find it at recoveryafterstroke.com/book. Want to go deeper and support the channel? Join the community at patreon.com/recoveryafterstroke. The post Plastics in Your Arteries: The Stroke Risk Study You Must Know appeared first on Recovery After Stroke.

Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.

Chronic inflammation is silently driving some of the most common diseases today — and most people have no idea it's happening. In this episode, Nurse Doza breaks down five hidden triggers: poor sleep, refined grains, low vitamin D, omega-3 deficiency, and digestive issues — and exactly what you can start doing about each one today. FEATURED PRODUCT Liver Boost – MSW Nutrition Chronic inflammation doesn't just live in your joints or your gut — your liver is at the center of it all. The liver filters inflammatory byproducts, processes environmental toxins, manages hormones, and supports fat digestion. When it's overburdened, your inflammatory load goes up. Liver Boost from MSW Nutrition is formulated with N-acetyl-L-cysteine (NAC), milk thistle, and selenium to support liver detoxification, protect your antioxidant defenses, and ease the total burden your body is carrying — making it a natural complement to everything discussed in this episode.

Buffalo Bills reporter Sal Capaccio stops by The Sports Bar to share the latests out of Bills OTAs.

Vinnie Dombroski of Sponge joins us, Eli Zaret in studio with a Pistons post-mortem, Rolling Stone's Greatest Punk Albums, Jason Biggs gets hot & dumps wife, and Meghan Markle delivers an AI speech in Geneva. Eli Zaret drops by the studio to recap the Detroit Pistons Game 7 loss to the Cleveland Cavaliers, Netflix steals TNF, hot takes on Ronda Rousey vs Gina Carano, discuss the floundering Detroit Tigers, preview the Detroit Lions 2026 season schedule, Tom Brady's modeling career, the WNBA's odd marketing strategy of eliminating Caitlin Clark, Cal Raleigh's superstitions, and more. Trudi Jasina's into the show. Mojo in the Morning had to be educated by Bark Nation over a joke. There is still time to donate to Thomas Markle. Jason Biggs and his wife have divorced… because he lost weight. Pete Davidson is an absentee father and terrible with money. Brad Pitt's children hate him and won't use his last name. Rolling Stone with their list of The 100 Greatest Punk Albums of All Time. Luigi Mangione has some evidence scrubbed in his case. Chicks still dig him. Wade Wilson, the Deadpool Killer, thinks he's hot. Every prison inmate in California needs an iPad. Zach Galifianakis tends to a garden these days. Vinnie Dombroski and Sponge will be rocking Rock & Brews in Royal Oak on THURSDAY, 5/21. Vinnie joins us using technology. Meghan Markle blabbed away in Geneva, Switzerland to 40 people. People Magazine continues to shill for that beast. RIP Mark Fuhrman. Eddie Kramer and Rick Beato collab. We remember the great Red's Tube Bar calls. Merch is for sale! Buy it. Or don't. But do. If you'd like to help support the show… consider subscribing to our YouTube Channel, Facebook, Instagram and Twitter (Drew Lane, Marc Fellhauer, Trudi Daniels, Jim Bentley, BranDon, and Roberto).

This episode of the Everyday Epigenetics: Raw. Real. Relatable. podcast takes a hard look at one of the biggest trends in the wellness world: detox culture. Susan Robbins shares a raw and deeply honest perspective on the fear-based messaging surrounding parasites, mold, heavy metals, cleanses, and “toxic overload,” while explaining what true detoxification actually looks like inside the body. From harsh protocols and supplement overload to the nervous system's role in health, this conversation challenges the idea that more detoxing always equals better wellness.Susan also dives into the genetics behind detox pathways, including MTHFR, COMT, PEMT, GST genes, inflammation markers, bile flow, and histamine responses. She explains why personalized health matters, why one-size-fits-all detox programs can backfire, and how stress, sleep, nutrition, circadian rhythm, and emotional safety often play a much bigger role in how the body functions than another cleanse ever will. This episode is a reminder that the body already knows how to detox when it has the right support, nourishment, and stability.In this episode:Why the detox industry often profits from fearThe difference between true toxic overload and depletionHow the body naturally detoxifies through the liver, kidneys, gut, skin, and lymphatic systemWhy harsh cleanses can create more stress on the bodyThe truth about parasite cleanses, binders, colonics, and juice detoxesHow chronic stress impacts detox pathways and hormone balanceWhy genetics like MTHFR, COMT, GST, PEMT, IL6, and TNF-alpha matter in personalized healthThe connection between histamine, sulfur pathways, glutathione, and detox symptomsHow nervous system regulation impacts healing and detoxificationWhy lifestyle rhythms, sleep, meal timing, and stress management matter more than most people realizeHow Susan uses epigenetics and PH360 health types to personalize detox supportThe importance of building resilience instead of living in fear around healthRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/05/18/episode124/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

The NFL Schedule dropped this past Thursday so we officially have a week-to-week breakdown to go over for the 2026 Bills season! Josh & Luka are back to give their initial thoughts about everything that is this Bills schedule as we sit here in mid-May. How we feeling about the New Highmark Stadium opener being on Thursday Night Football in week 2? Is opening the season at the Houston Texans actually a good thing? What is up with the Bills ending up on both Thanksgiving night hosting the Chiefs AND being on the road to take on the Broncos Christmas night?? All that & more on this week's Bills Chat Podcast!

Can Stroke Recovery Happen Years Later? The Griffith University Etanercept Trial Answers If you caught my recent video about UCLA's discovery of the first stroke rehabilitation drug that rebuilds brain connections in mice, you know the incredible excitement it generated. If you missed it, the link is in the description below. It's definitely worth a watch. Because of the huge response and the many messages from stroke survivors asking for more real recovery options, I wanted to take a deeper look at another breakthrough: The Griffith University study on using a drug called etanercept to help stroke survivors, not just weeks after a stroke, but even years later. And trust me, the results are eye-opening. Today, I'll walk you through what the study found, how it was set up, what it means for all of us, and where things are heading next. What Was the Study About? Researchers at Griffith University in Australia asked a bold and important question: Can etanercept help stroke survivors still living with chronic pain and movement problems, even many years after their stroke? They weren't looking for tiny improvements – they wanted to see fast, meaningful, life-changing results. This study wasn't designed for people who have just left the hospital. It was for survivors who had had their strokes at least six months ago, with some having had strokes over 15 years earlier. Why Did They Do It? Chronic post-stroke pain, or CPSP, is one of the most devastating outcomes of a stroke. It's not just muscle pain. It's deep nerve pain, constant, burning pain that regular medications like oxycodone or pregabalin often can't touch. Researchers now understand that this ongoing pain is often caused by inflammation in the brain, specifically driven by a chemical called TNF-alpha. Etanercept is a drug that's been used safely for over 20 years to treat arthritis and autoimmune conditions because it blocks TNF-alpha. The Griffith team wanted to test whether using etanercept to block brain inflammation could unlock recovery, even years after a stroke. How Was the Trial Set Up? This wasn't a casual or loose experiment – it was a carefully designed, professional clinical trial. Here's how it worked: 26 stroke survivors participated. Ages ranged from 30 to 80 years old. Strokes had occurred 6 months to 15 years earlier. Every participant had moderate to severe daily pain (rated between 4 and 8 out of 10). All had hemiparesis, or weakness on one side of the body. Participants were randomly assigned to one of two groups: One group received etanercept injections. The other group received placebo injections (just sterile saltwater). Each person received two treatments: One on Day 1 Another on Day 14 The injections were given near the neck in the perispinal space, allowing the drug to travel quickly to the brain. What Were They Measuring? The researchers focused on solid, measurable outcomes: Pain levels – using a 0–100 scale combined with a faces pain chart. Shoulder movement – measuring how far participants could lift their weaker arm. Sensation – testing for improvements in feeling hot, cold, and pressure. Cognition and fatigue – although big changes weren't expected here. Participants were monitored closely for 30 days after their first injection. What Happened? Here's what the trial revealed: Pain Relief 70% of the participants in the etanercept group experienced significant pain improvements. Pain levels dropped by an average of 24 points out of 100. 3 out of 10 participants experienced near-complete pain relief — often within 30 to 60 minutes of their first treatment! Meanwhile, the placebo group showed almost no change. Mobility Gains 9 out of 10 participants in the etanercept group regained more shoulder movement. 6 regained at least 60 degrees of motion. 3 participants fully regained 180 degrees — meaning full overhead shoulder motion. Sensory Improvements Many participants began to feel heat, cold, and pressure better on their affected side — a strong sign that nerve function was returning. Side Effects Only one major side effect was reported: one participant developed shingles and had to withdraw from the study. No other serious adverse events were recorded. What Does It Mean? If these results hold up in larger, longer studies: Stroke survivors could have a real option for reducing chronic pain and restoring lost movement. It could dramatically lower reliance on heavy opioid medications. Most excitingly, it shows that the brain may still be capable of healing years after a stroke — if inflammation is correctly targeted. However, it's important to remember: This was a small trial. Etanercept is not yet officially approved for stroke recovery. And the treatment doesn't work for everyone. But it's a huge, hopeful step forward. A Word About Dr. Tobinick It's important to acknowledge someone who helped make all this possible: Dr. Edward Tobinick. Dr. Tobinick was the first to use perispinal etanercept for stroke survivors back in the early 2000s. He was featured on 60 Minutes Australia in 2011, showing stunning recoveries that few thought were possible. Despite facing skepticism, lack of pharmaceutical company support, and high treatment costs, Dr. Tobinick kept pushing forward. Without his work, many stroke survivors wouldn't even know this therapy existed. You can find the link to that original 60 Minutes interview in the description. What's Next? Because of all the interest from our community, I'm reaching out to researchers at the Florey Institute in Australia. They’re currently working on new therapies for stroke recovery, and I'll update you on: Where their research stands What new options might become available And how close we are to real-world treatments for stroke survivors Stay tuned, as soon as I hear back, I'll share everything with you. Want to Dive Deeper? If you’d like to read the full Griffith University study, the link is in the description. The brilliant researchers behind this study include: Dr. Stephen J. Ralph Dr. Andrew Weissenberger Dr. Ventzislav Bonev Dr. Adrienne Goodman-Jones, and others from Griffith University and partner institutions. They deserve real recognition for pushing this research forward. Final Thoughts If you found this article helpful, Please subscribe, comment, and share this post with someone who might need hope today. And if you're listening on Spotify or Apple Podcasts, please leave a review. It helps more stroke survivors find this channel and this growing community. The post Etanercept and Stroke Recovery: Breakthrough Griffith Trial Results You Need to Hear appeared first on Recovery After Stroke.

The NFL dropped the full 2026 schedule and the rest advantages, short weeks, and brutal road stretches are already telling a story. We're breaking down the biggest winners and losers from a pure scheduling luck standpoint — who's set up for a run and who's already playing from behind.  Sign up for PrizePicks with code: HMA and get $50 in lineups instantly when you play your first $5+ lineup! https://link.prizepicks.com/LME0/DAMON  For advertising opportunities: contact@hogmedia.co  Support the show by becoming a member: https://www.youtube.com/channel/UCcs13VXhiObJg6jGDw2xbZg/join All Damon Bruce Plus content is available on your favorite podcast platform: https://pod.link/1681177856.  #49ers #NFLScheduleRelease #SanFrancisco49ers #NFLSchedule2026 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The 49ers got their 2026 schedule and there's a lot to unpack. We're going game by game — from the NFL's first ever game in Australia to a Sunday Night Football showdown in Mexico City to a late December home game against Kansas City. Who do they have rest advantages over? Where are the traps? Is the bye week placement a win? Full breakdown right here. S ign up for PrizePicks with code: HMA and get $50 in lineups instantly when you play your first $5+ lineup! https://link.prizepicks.com/LME0/DAMON  For advertising opportunities: contact@hogmedia.co  Support the show by becoming a member: https://www.youtube.com/channel/UCcs13VXhiObJg6jGDw2xbZg/join  All Damon Bruce Plus content is available on your favorite podcast platform: https://pod.link/1681177856. #49ers #NFLScheduleRelease #SanFrancisco49ers #NFLSchedule2026 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Maren Hamilton ran global social at The North Face — building and executing a strategy for 5.5 million followers, integrating athletes and creators, and navigating every platform shift from the follow graph to the discovery graph. Then she left to help build Popfly, the creator platform built specifically for the outdoor industry. In this conversation, Maren shares the playbook she developed at TNF for running brand social at scale, including how to say no to the hundreds of internal requests that flood every social team, why the outdoor buying journey is fundamentally different from fashion and beauty, and what brands still get wrong about TikTok, Threads, and Facebook. Plus: Why Head of Social to CMO is now a real career path, what makes a creator pitch actually land with a brand, and the Adidas sub-two-hour marathon moment that might be the greatest brand activation of the decade. Second Nature is supported by Popfly. If you want to support our podcast - and discover a platform that we believe is one of the best tools for connecting brands and creators, follow these links: Popfly for Creators/Athletes: https://popf.ly/secondnaturecreators Popfly for Brands: https://popf.ly/secondnaturebrands Show Notes:  Maren Hamilton: https://www.marenhamilton.com/ Popfly: https://popf.ly/secondnaturebrands TNF Instagram: https://www.instagram.com/thenorthface DBo on X: https://x.com/dylanbo TikTok: https://www.tiktok.com Gnara on TikTok: https://www.tiktok.com/@gnara_apparel?lang=en Taylor Hoekstra: https://www.linkedin.com/in/taylorhoekstra/ Popfly Storefront: https://app.popfly.com/@superridertv/storefront Alpaka: https://www.alpaka.com Camp Chef: https://www.campchef.com Backcountry: https://www.backcountry.com BPC - Brand, Product, Content: Halfdays x HOKA: https://www.halfdays.com/pages/hoka-x-halfdays Keen x 18 East: https://www.keenfootwear.com/collections/keen-x-eighteen-east Gnarly Nutrition x DBo: https://www.youtube.com/watch?v=qPtESorSIso Supercommunicators (Book): https://amzn.to/3RcJ7W6 Supercommunicators (Podcast Episode): https://open.spotify.com/episode/3jqbbLEHbZyEJ2kMqNskkz Adidas Pro Evo 3: https://www.adidas.com/us/adizero-adios-pro-evo-3-shoes/KH7678.html Join us on LinkedIn: https://www.linkedin.com/company/second-nature-media Meet us on Slack: https://www.launchpass.com/second-nature Follow us on Instagram: https://www.instagram.com/secondnature.media Subscribe to our newsletter: https://www.secondnature.media Subscribe to the YouTube channel: https://www.youtube.com/@secondnaturemedia

Full Show Broadcast. Buffalo Bills Greg Rousseau & Matthew Fairburn on the show. Gene reacts to the Sabres game 5 loss & the Bills 2026-27 schedule. Timmy has his take. Gene shares shots & last call.

Gene gets you all set for Sabres & Canadiens "pivotal game 5." Happy NFL Schedule Release Day. Gene has your leaks as he attempts to paste the entire Bills schedule together.

Gene has schedule leaks: The Buffalo Bill play week 1 in Houston. Plus other not officially announced games.

The 49ers are heading to Australia to open the season against the Rams on Thursday Night Football, and this matchup could set the tone for the 2026 season. Wayne Breezie breaks down the travel, pressure, playoff implications, and why this game means way more than people realize.

(00:48) Full 2026 NFL Schedule release - Thursday, 8pm (37:40) Cowboys will host Eagles on Thanksgiving (Week 13, 4:25PM, FOX) (41:37) SNF Opener: Cowboys at Giants, Sunday September 13 (48:30) MNF Opener: Broncos vs Chiefs, Monday September 14 (50:50) Bills open new stadium in Week 2 on TNF vs LionsSee omnystudio.com/listener for privacy information.

In this episode of Next in Media, Mike Shields sits down with Alan Moss, VP of Global Advertising Sales at Amazon Ads, to talk about Amazon's rapid transformation into a full-funnel advertising powerhouse. Alan walks through how he joined Amazon mid-COVID in 2020 and within a few years helped land an 11-year NFL deal, launch Prime Video ads, and close an NBA partnership that made Prime Video a year-round sports network.  He and Mike dig into what's working in the upfront market, why Amazon sees retail media and streaming as one unified full-funnel business, and how Amazon DSP's partnerships with Netflix, Disney, Roku, and others now reach 90% of household audiences. They also get into the growing role of Twitch and creators as a mid-funnel marketing lever, and why Alan believes the future is AI agents — not just for creative optimization, but for full campaign orchestration. Key Highlights

Tim Schneider shares his take of the day & Gene lines up shots.

Full Show Broadcast features. Matt Parrino on the Buffalo Bills. Owen Parker from WGR-550 previews Sabres & Canadiens game 4 tonight in Montreal. Timmy shares his hot take, Gene has shots & last call is for you.

Full Hour 1. Gene talks the Sabres & Canadiens game 4 tonight. Buffalo made some lineup changes. The Buffalo Bills open New Highmark stadium when they host the Detroit Lions in week 2 on Thursday Night Football. Matt Parrino stops in to go over the latest Bills news.

Matt Parrino, who covers the Bills for the Syracuse Post Standard & The Shout Podcasts stops in. The Bills will open New Highmark Stadium in week 2 vs the Detroit Lions on Thursday Night Football. Matt also dishes on Bills rookie mini camp, free agent signings, the latest news & the Sabres.

Gene starts the show off discussing the Sabres must win game 4 tonight in Montreal. Buffalo made some line-up changes. The Buffalo Bills will open New Highmark Stadium in week 2 vs the Detroit Lions on Thursday Night Football. How good are the Lions? Who will Buffalo play in week 1?

In this episode of The Jonathan Wier Show, Jonathan and co-host Cody Akins tackle the upcoming NFL schedule release (Thursday, May 14th at 7 PM CT) and debate which team they want the Chiefs to open against. Cody wants the Jets for an easy motivational win, but Jonathan argues for the Seahawks — repossess their banner on banner night and give Kenneth Walker his revenge game. The conversation pivots to a bigger problem: the NFL is becoming the world's biggest mall. With games now scattered across Netflix, Peacock, Prime, Paramount+, YouTube, and Netflix again, Jonathan argues the league is sacrificing its big-box-store accessibility for greed. He doesn't mind games on different days — but the fragmentation across paid services is going to cost them casual fans. The guys then debate the Star Fox 64 remake for Switch 2. Cody is genuinely excited (and hopeful it signals an Ocarina of Time remake for Zelda's 40th anniversary). Jonathan sees it as another nostalgia trap — Nintendo knows aging millennials will buy it no matter how much they complain, the same playbook George Lucas ran with the Star Wars Special Editions in the '90s. They close on tech policy: Utah trying to ban VPNs (unenforceable and ignores how cellular IPs work), and Meta rolling out AI age verification because kids are bypassing checks with mustaches, hats, haircuts, and makeup. Jonathan's takeaway — parents need to stop delegating parenting to the government. Talk to your kids. Block sites on your router. Do the work.

Rich and the guys react to the Oklahoma City Thunder's Game 1 win over the Lakers and weigh in on the NBA's ongoing flopping problem. ‘Thursday Night Football' Analyst Andrew Whitworth and Rich discuss the NFL's upcoming schedule release, why Cincinnati Bengals fans (and Joe Burrow) should be excited by the team's offseason moves, and the Rams drafting QB Ty Simpson despite having Matthew Stafford still playing at an MVP level. Rich reacts to a proposal by the American Football Coaches Association that would eliminate CFB conference championship games and more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Can you decrease inflammation naturally, without stopping medication?In this in-depth masterclass, Dr. Isabelle Amigues, double board-certified rheumatologist and metastatic breast cancer survivor, explains the science behind the nervous system and inflammation connection.You'll learn:• The relationship between the immune system and the autonomic nervous system• What the inflammatory reflex is• How vagus nerve stimulation lowers TNF, IL-6, and inflammatory cytokines• Why FDA-approved vagus nerve devices are changing autoimmune treatment• Practical, science-backed techniques to lower inflammation naturally• How breathing, cold exposure, and mindful movement activate the parasympathetic systemThis is not “instead of medication.”This is about expanding the toolbox.If you have rheumatoid arthritis, lupus, gout, or any inflammatory condition — this conversation will change how you think about healing.Hope, driven by science.

Sleep and weight gain are directly connected. Poor sleep disrupts hormones, raises blood sugar, tanks testosterone and estrogen, causes fatty liver, and wrecks your gut. If you've been doing everything right and the scale won't move, your sleep could be the missing link. FEATURED PRODUCT Chill by MSW Nutrition is a powdered drink mix formulated to support your body's natural calming chemistry — exactly what's needed when chronic stress and cortisol overload are stealing your sleep. Featuring GABA, L-Theanine, myo-Inositol, Taurine, and Magnesium, Chill helps balance neurotransmitters, quiet the nervous system, and promote the deep, restorative sleep your hormones, metabolism, and weight depend on — all five mechanisms discussed in this episode.

Join Professor Iain McInnes and Professor Rieke Alten for the latest episode of Discussing RA on The Immune-Mediated Inflammatory Disease Forum. In this episode, they will review a paper by Smolen et al. provides an update of the EULAR RA management recommendations addressing the most recent insights; and by Narváez et al. developed evidence-informed, profile-based recommendations to guide treatment selection after inadequate response to a first TNFi in RA, combining evidence and expert consensus.

Episode Show NotesWe've been taught to believe that more exercise equals better health, stronger bodies, and faster results. This episode challenges that belief in a big way. Susan breaks down how pushing harder and training longer can actually backfire, leading to chronic inflammation, disrupted recovery, and even long-term health consequences that often go unnoticed.This conversation goes deeper than surface-level fitness advice. It connects the dots between genetics, lifestyle, and training patterns to show why two people can follow the exact same workout plan and experience completely different outcomes. From inflammatory gene responses to stress hormone regulation and recovery capacity, your body has a unique threshold, and ignoring it can quietly work against you.Susan also walks through how overtraining shows up beneath the surface, even when you feel “fine.” Blood markers, nervous system dysregulation, sleep disruption, and metabolic shifts all play a role in whether your body is adapting or breaking down. The goal isn't to stop moving, it's to train with precision, honoring your body's rhythms, recovery needs, and individual design.By the end of this episode, you'll have a new lens on exercise, one that prioritizes alignment over intensity, and sustainability over burnout. Because real progress doesn't come from doing more. It comes from doing what actually works for your body.In this episode:Why too much exercise can trigger chronic inflammation and slow recoveryHow genetics influence your response to stress, training, and inflammationThe role of stress hormones like cortisol in overtraining and burnoutKey gene variants (like COMT, IL-6, TNF-alpha) and what they mean for your bodyHow different health types respond to exercise, and why personalization mattersThe hidden signs of overtraining, even when you feel “healthy”Blood markers to watch for (fasting insulin, triglycerides, CRP, glucose)How chronobiology (timing) impacts performance and recoveryWhy recovery, not intensity, is where real progress happensHow to train smarter by aligning with your body's natural capacityRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/04/27/episode121/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

In this episode, Cheryl sits down with Brad Pitzele to unpack a long and complicated health journey that began with early autoimmune symptoms and escalated into psoriatic arthritis, debilitating fatigue, and eventually melanoma linked to immunosuppressive treatment. Frustrated by a system that offered only escalating medications and limited answers, Brad began an intense period of self-experimentation and research. His turning point came after a Lyme disease diagnosis, one that helped connect years of seemingly unrelated symptoms. This ultimately pushed him deeper into understanding the root causes of chronic illness, especially the role of mitochondrial dysfunction and inflammation. From there, the conversation shifts into the tools that helped Brad reclaim his health, including exercise with oxygen therapy (EWOT) and red and near-infrared light therapy. He explains how both approaches work at a cellular level to improve oxygen delivery, support mitochondrial function, and reduce inflammation. Thseare are all mechanisms that have implications for conditions like chronic fatigue, autoimmune disease, multiple sclerosis and even cardiovascular health. This episode is a deep dive into resilience, curiosity, and the power of continuing to search for answers when conventional paths fall short, offering both practical insight and hope for anyone navigating complex or unexplained health challenges. Connect with Brad at One Thousand Roads. Disclaimer: Links may contain affiliate links, which means we may get paid a commission at no additional cost to you if you purchase through this page. Read our full disclosure here. Takeaways Chronic symptoms do not always have clear answers and standard care often focuses on managing symptoms rather than addressing root causes Mitochondrial health plays a central role in energy, recovery, and overall resilience and when it is compromised nearly every system in the body is affected Inflammation and low oxygen levels go hand in hand, creating a cycle that can worsen chronic illness over time Exercise with oxygen therapy works by increasing oxygen delivery to tissues and may support energy production and reduce inflammation Red and near infrared light therapy may enhance mitochondrial function by increasing cellular demand for oxygen and boosting energy output Combining oxygen therapy with red light can create a complementary supply and demand effect at the cellular level Healing from complex or chronic conditions is rarely quick and consistent cumulative inputs over time matter more than short term fixes Self advocacy and curiosity are critical when navigating unexplained health issues or when conventional approaches fall short Small improvements over time can rebuild momentum and hope even before full recovery is achieved Simple inputs like oxygen, light, and movement can have powerful effects when applied consistently and strategically Watch on YouTube Disclaimer: Links may contain affiliate links, which means we may get paid a commission at no additional cost to you if you purchase through this page. Read our full disclosure here. CONNECT WITH CHERYL Shop all my healthy lifestyle favorites, lots of discounts!  21 Day Fat Loss Kickstart: Make Keto Easy, Take Diet Breaks and Still Lose Weight  Avaline Wines, Tested and Clean, Sugar Free Drinking Ketones Wild Pastures, Clean Meat to Your Doorstep 20% off for life  Clean Beauty 20% off first order DIY Lashes 10% off  NIRA at Home Laser for Wrinkles 10% off or current promo with code HealNourishGrow Instagram for daily stories with recipes, what I eat in a day and what’s going on in life Facebook YouTube  Pinterest TikTok Amazon Store The Shoe Fairy Competition Gear Getting Started with Keto Resources The Complete Beginners Guide to Keto Getting Started with Keto Podcast Episode Getting Started with Keto Resource Guide Episode Transcript Cheryl McColgan (00:00)Hey everyone, I’m Cheryl McColgan and today I am joined by Brad Pitzley and we are going to talk about some of his health history. He has a really interesting background with some challenging diseases and scenarios that he went through. And you know, like many of the guests on the HealNursery podcast, he just has a health journey that he wants to share with people and kind of what ended up actually helping him. Because so often people go down these roads with different conditions and they just have a lot of trouble finding out number one what it is, number two if there’s anything that can help them feel better or how to treat it. And so I think Brad’s going to have a lot of really interesting things to share with us today. So Brad, if you could just maybe start by, I don’t know how far in the way back machine you want to go, but kind of just, you know, give us a little bit about your health journey. And as we go along, I’m sure I’ll have some kind of questions to fill in for everyone. Brad Pitzele (00:50)Yeah, I had weird health things going on since grade school. I was diagnosed with psoriasis, but then I had other weird things that just kind of came and went. We’d go to the doctor, they’d give it a label. It would last for a while. There was no treatment for said label and then it would kind of just disappear and then I’d move on with life and then a year or six months or whatever, something else might pop up. But it really kind of started to come to a head. Um, probably around 2010 or 11, I started to develop autoimmune arthritis, what was considered psoriatic arthritis, which is, it’s basically like rheumatoid arthritis, but it’s what you get with psoriasis. Um, and they started to test all sorts of different drugs on me. The first sets didn’t work. Then they put me on, um, some immune suppressive drugs. They gave me relief for like maybe six months and they’d start wearing off and they would double the dose and they’re. I was kind of worse off when it wore off and then it would kind of bring me up a little bit. And then was kind of like I was taking a stair step into, you know, into a worse and worse place. And I was on those drugs for probably about two years. And then I developed melanoma. And that’s one of the side effects of the drugs is it’s got a high risk of cancer and specifically melanoma. So that was kind of a, a jumping off point for me. I, during that period, I also started to develop weird other symptoms. Like I started to get stiffness in the back of my legs. had tremendous brain fog and energy issues. had pain in my feet and I would take this back to the rheumatologist and I’d be like, this is, is this part of the, this disease? assume. he was like, no, that’s not part of the disease. And I was kind of shocked and like, well, it feels like part of the disease. It’s kind of, you know, it’s just. Cheryl McColgan (02:38)All right. Brad Pitzele (02:41)another symptom of whatever’s going on with me. But he didn’t really acknowledge that. And then when I got cancer, I went back to him and I was like, Hey, you know, I’m really afraid I’m like, if I keep taking these drugs, more risk of cancer. I don’t take these drugs. I, you know, I die, cripple crumpled up in a ball in the corner, so to speak. And he was kind of like, no, I don’t think that’s going to happen. Yeah. I think we’re just going to try another drug in the, the, the same category. And that was like, just started having alarm bells in my head. Just started shouting at me. was like, either path feels like it’s very bad. And I was a, I had a young children at the time. I was a relatively new father and that was even more scary. I was kind of the single income in the household. And I just started like, I’m like, what happens if these things happen to me to not just me, but my family. and that’s kind of when I started jumping off and like doing my own research and trying to figure out what I call a third path for because neither of those really made sense to me. Cheryl McColgan (03:40)those both sound like not very good options. I’m just kind of curious when you were going back to the doctor with these things, kind of two questions here actually. One, and I think I already know the answer, but one, were drugs the only answer that this doctor was able to give to you? And secondly, I think having the cancer being a known side effect of the drug is really interesting. you ever talk about what the mechanism there is or anything to know about that just for people with curiosity? Brad Pitzele (04:07)Yeah, so yeah, mostly it was drugs. He did also offer me injections of steroids into some of my joints. He was very skilled at it, because he said it was gonna be very painful. It wasn’t that painful, but steroids turn off your immune system. And it’s the same thing with some of the drugs I was on. One of them was a… I won’t call brand name, but it was a TNF inhibitor. TNF stands for tumor necrosis factor. And it’s basically in a component of our immune system. And so there was some research done and they found that if they turned off that component of your immune system, hey, the pain and symptoms go away. Unfortunately, as the name alludes to, it kills tumors. when you turn it, we all have cancer in our Cheryl McColgan (04:49)Yeah Brad Pitzele (04:52)body. Like right now as we speak, everyone has it. It’s just our immune system is able to kill it off and so it never really gains a foothold. But once you start tipping the balance of the scales, obviously, you know, it can run amok. And that’s what happened in my case. Cheryl McColgan (05:08)Yeah, very interesting. also it just brings up so many other questions that I’ll have to go down a rabbit hole after we’re done with our conversation. But so you had these things, you didn’t have good relief, you were still having symptoms, then you got cancer. And I assume obviously you had to get treated for that at that point. Was that really the turning point for you to just be like, I’ve got to find some other way to manage this? How did how did things go from there? Brad Pitzele (05:30)Yeah, it was, and I’m not gonna tell you it was a fast turn for me. It took me several years. But I mean, from there, I just started reading anything I could. I read books, I was out on the internet, I was in chat groups talking to other people who had similar symptoms, Facebook groups, Googling on PubMed, looking at research, so many rabbit holes I ran down. I was joking, I’m recovering engineer. ⁓ I got my undergraduate in mechanical engineering, so I’m very analytical by my nature, I suppose. Research didn’t scare me, and I just was reading anything I could. I wasn’t gonna… Cheryl McColgan (05:55)You Brad Pitzele (06:07)You know, wait for them to find something in the research and then try to translate it 20 years later. Like that does me no good. and I tried everything. I did a lot of self experimentation, everything from complete changes of diet, supplements, so many, mean, different modalities, all sorts of weird stuff. Sometimes my family looked at me pretty good side, I when they saw some of the stuff I was doing. but you know, when you’re, when you’re really desperate and. things are getting worse and worse. And particularly when you also feel this responsibility and obligation to your family, you just, it’s not even just about you. You’re like, what do I do? I like, I’m gonna disappoint all these people and life is not gonna be good for them. I just told myself, I’m not allowed. know, like this is absolutely not allowed. This is not gonna happen, but it kept happening for a few more years. And then, I ended up at a doctor’s office and he tried all sorts of things. Nothing was working. He was an MD, but he was non-insurance, so was integrative. And he was trying all sorts of alternate modalities on me. Even the things he was sure were gonna do anything, nothing was doing anything. He’s doing testing on me, nothing was popping. And then he suggested I do a Lyme disease test. I remember thinking, I’m like, doctor, I don’t have Lyme disease. I’m like, I’ve never been bitten by one of these ticks. I’ve never had that bullseye rash thing. I’m thinking to myself, I don’t have that. But I was kind of like, you know what? And it was expensive test at the time. It was like 500 bucks. Insurance didn’t pay. But I was like, you know what? I’m gonna pay the 500 bucks. I’m gonna do the test so he can see it’s negative and we can get him off this Lyme thing. We can get to the real deal because it’s not Lyme. And sure enough, it came back that I had Lyme disease and one of its co-infections called Bartonella, which is the infection that causes cat scratch disease as well. And I was so shocked. went back to him. was like, doc, what’s the chances this is a false positive? I don’t think I have it. And he was like, Brad, it’s a urine PCR, which means you have the DNA of those bacteria in your urine. What do you think is the chances it’s, it’s false positive? I’m like, got it. Cheryl McColgan (08:12)Not. Brad Pitzele (08:14)And that’s when it finally started to hit. ⁓ Cheryl McColgan (08:16)Well, just for people that aren’t familiar, I think everybody’s kind of heard of Lyme disease at some point, maybe Bartonella, but what did that kind of mean to you at the time? Like I’m sure once you got that diagnosis, you wanted to learn more about it. Were you thinking that that explained some of the things that you had up to this point or how did that mesh into the whole symptom profile? Brad Pitzele (08:36)Life disease is incredibly challenging. for a variety of reasons. One, it’s very difficult to get under control. There’s a lot of folks in America and across the world, quite frankly, suffering with it right now. The other reason it’s tough is there’s not a lot of doctors willing to treat it. There’s this whole stigma about it. What makes it particularly difficult is there’s this question on if it actually exists in some doctor’s head. It’s like the weirdest thing in the world. We know there’s this infectious agent, we know it infects humans, and yet when a human comes to the doctor and says, I’ve been infected by it, they’re like, are you sure? And so you kind of get, I think the term I hear often is medical gas lit. And on top of that, doctors, for legal reasons, often don’t want to touch it. So my doctor didn’t want to touch it. And he was like, look, you have to go to a Lyme specialist three hours away. I recommend him as best I can. And it was a long waiting list to get into this doctor’s office. And while I was waiting, just… I was relentless, you I just couldn’t sit here and let myself deal with all this. It was a three month wait. And so I just started reading voraciously on Lyme disease to your point. was reading all sorts of research. I was reading books on it, a lot of books on the, like the science and what was happening to your body mechanically. And it was actually pretty eye opening because when I started to read all these symptoms, I was like, I started to piece together all these pieces, the puzzle that happened to me in my childhood, ⁓ things that happened Cheryl McColgan (10:12)Mm. Brad Pitzele (10:13)more recently, things that the rheumatologist couldn’t explain, but now we’re clear as day what was going on. And so the jigsaw puzzle started to fall into place for me. So it was kind of an epiphany from that perspective, yeah. Cheryl McColgan (10:29)Yeah, that’s got to be the waiting had to be one of the hardest things, I’m sure. then once you finally got to him, did he because he was specialized in Lyme specifically, did he have any solutions for you? Or then was it somewhere that you still had to go to go down the road? Brad Pitzele (10:42)No. You know, the disappointing thing is, I ended up, the whole family was diagnosed with Lyme disease, not just me, my children and so forth. So we all carted in the car down three hours from, I live in Dallas area down in Austin. He had a lot of things to say to us. It was kind of stuff I’d already read. Most of it I’d already tried. know, supplements I’d already run through myself and like it became cost prohibited both the time and the visitation and we just didn’t get anywhere. So we probably visited him. five or six times and then I was like, okay, well this is not, know, and was, each time it was kind of clear, like his tools were somewhat limited. And so then it was time to kind of, while I was doing his stuff, I was also just actively experimenting. was, you know, was a, you know, a test dummy every set, every second of it, because again, you know, you just can’t wait, you know, come back in two months. You’re like, if this thing doesn’t work in a few weeks, I got to, I’ll keep doing it, but I’ll add other things. See where I go. Cheryl McColgan (11:46)Right, well, I’m sure once you knew that your whole family had this issue that probably made you want to solve it even more, not that it wasn’t enough for you to solve it for yourself, but now you’ve got other people in your family that you want to feel well, you know? Brad Pitzele (11:53)Yes. Absolutely, absolutely. was definitely set heavy on my mind. Just I didn’t want the kids to have to go down this path. Cheryl McColgan (12:06)So this kind of leads us into this whole backstory into the sign that’s behind your head right now, 1000 roads, because you kind of did that many roads to get here, right? And so what did you come across? I thought that was like one of the best business names I’ve ever seen, the way, knowing the backstory. But anyway, what was it that you found in the research or what led you to kind of, there’s a couple of things that did end up helping you, which is awesome, because I think now we’re going to share this with people because Brad Pitzele (12:16)Yeah, that’s right. you Thank you. Cheryl McColgan (12:35)Like you said, there’s plenty of people out there with Lyme disease. There’s plenty of people out there with unexplained illnesses or things that are affecting them. And, you know, there are some interesting tools that do work, worked in your case. So how did you end up finding what actually ended up working for you? Brad Pitzele (12:50)Well, I eventually started doing a lot of research on all sorts of things. And one thing that stuck with me was mitochondrial health. I hear more and more folks talking about it in recent years, which is great, but this is probably about a little 10, 12 years ago. It really wasn’t a well-spoken about area. the more I researched about mitochondrial health, the more I realized this is at the root of everything. So for your listeners, the mitochondria are this little organelle, this little subset inside all of your cells that produce the energy. And they’re extremely fragile. And when they get damaged or they’re not working efficiently, nothing works efficiently because everything takes energy, right? Us talking takes energy, thinking takes energy, moving our muscles, our organs working take energy, repair our immune system, all of it. And so often when you’re dealing with chronic health conditions, particularly when you’re dealing with an infectious agent or even cancers, they go after our mitochondria. because they kind of take the power down in the system and that gives them a leg up on our immune system and our defenses and it allows them to kind of I would call it just burrow deeper into our biology and you know shift the biology to be more favorable towards whatever that is. So for me it that was kind of an epiphany and I delved into a couple tools and the first one was something called exercise with oxygen therapy. also known as EWOT, E-W-O-T. No one was really talking about it. It was kind of the small little thing, not a lot of information out there. And then there was a second one, more folks have heard of today, which is red light therapy, and really red and near infrared light therapy. And they both work through mechanisms that help the mitochondria restore itself. Cheryl McColgan (14:45)Yeah, the exercise, I was looking at the photo on the website of the EWOT contraption and I’m kind of having a hard time conceptualizing. think what, and actually before we go into that, let’s address this other question that came up in my mind when I was looking at the contraption, because I’m like, okay, the thing that most people are probably somewhat familiar with nowadays is a hyperbaric oxygen chamber. And that is used in cancer treatment. think it was, Dr. Seyfried has this thing, and you might be familiar with him just like. through your mitochondrial research, but it’s called like a press pulse thing that they use with cancer patients. And it has to do with ketogenic diet, because you’re starving the cancer of sugar. And then also this hyperbaric oxygen therapy. That’s, that’s all just kind of a weird aside for people that are hearing this, it really has nothing to do with this conversation. But it’s interesting to look up. But for your thing, the hyperbaric works in one way. And I think people like you can visualize it, because you go in and you kind of just lay down. And that’s what it is. But this And when people go to the website, they’ll see it. It’s kind of, looks like a big balloon or a box. So guess I’m having trouble kind of conceptualizing how do you even use that or, how do you exercise with that? That’s a very long winded question, but hopefully we’ll get there. Brad Pitzele (15:47)Yeah. Sure. Well. Yeah, that’s great. So I think it’s two questions. What is it? How does it work sort of thing? Exercise with oxygen therapy at its principles really simple. It simply involves doing any sort of exercise, preferably something that gets your heart rate up, generally cardiovascular exercise, while wearing a mask and breathing near pure oxygen, so about 93 % oxygen. So to your point about how does the contraption or the EWATS system work, it works as, it’s like this, there’s actually a device called an oxygen concentrator that can produce an endless supply of oxygen. You plug it into the wall and you flip the switch and it takes the oxygen in your room, which is probably at like let’s say 21 % at sea level, and it purifies it to 93 % oxygen by separating out the other gases, the nitrogen and the argon. which is great, but these machines that you can plug into your wall, your home outlet, they produce only five or 10 liters of oxygen in a minute. And when you exercise, you can easily use 50 or 60 liters in a minute. So to get a 15 minute session in, you can easily use 900 plus liters of oxygen. And that machine’s only putting out at the best 10 liters of it. And so every minute. And so what we do is we take that machine and we fill a large reservoir to a thousand liters. So think of it as about six feet, five and a half, six feet squared. It looks like a big pillow. And we fill that thing with oxygen. Now to like dimensionalize this for folks, a thousand liters of oxygen is similar to the amount of oxygen you’ll breathe in an entire day. And we’ll fill this, this, you know, bloom, what we call a reservoir with oxygen. And then we’ll attach a hose with a mask on the end of it. Put the mask on and you just breathe out of that reservoir. of water. So again, in that 15 minutes, you can take in a whole day of oxygen. It’s really a massive amount. Now, how does it compare to hyperbaric oxygen? That’s a really good question. Hyperbaric oxygen, at its core, what you do is you get inside of a chamber, they pressurize it, and that forces more oxygen through your lung membrane and into your blood. Now, Once it gets past your lung membrane and into your blood, your, what happens in hyperbaric oxygen is it goes not just into your red blood cells, because if you look at your red blood cells right now, which are the parts of your blood that are designed to carry oxygen, they’re at capacity. Like you can put a little pulse oximeter on your finger and it’ll say 99 % or 100 % or 98%. And so there’s not room for more oxygen, but what hyperbaric does, and EWAT does the same thing, is it actually forces oxygen into your blood plasma. Now blood plasma is this clearish brown liquid, it’s effectively water plus plus, that all the red and white blood cells ride on. And so it can actually turn that into an oxygen carrying vehicle inside your blood, something that normally doesn’t carry very much oxygen. And that’s through a process called Henry’s Law, which goes beyond human biology. It’s really just a chemistry law that says, you take an insoluble gas and enforce it on top of an insoluble liquid, it’ll force the gas to go into solution. In this case, the gas is oxygen and the liquid is blood plasma. Now, in hyperbaric oxygen, the body tries to get back into balance. It notices there’s a surplus of oxygen in the blood. And so your body tries to regulate, go back to homeostasis by using something called vasoconstriction, which means your blood vessels constrict. They get smaller to allow less of that oxygen through. So your body is naturally fighting against delivering that oxygen. In spite of that, you deliver a large dose of oxygen to the tissues. In IWA, what we do is we come to the opposite. Instead of using pressure to force more oxygen into and through your lungs, we use exercise to pull it through. So when you start exercising, your body immediately recognizes that it needs more energy. And the gating factor in producing more energy is oxygen. We all in this Western world generally get enough food. It’s just we’re… When you’re exercising, there’s not enough oxygen. So when it notices this, you have all these physiological changes, right? You start breathing faster and deeper. Your lung membrane actually thins out to allow more oxygen to pass through. Your heart starts beating faster. Every beat is deeper. Your blood vessels actually dilate. They actually open up to allow larger blood flow through them. And then when you exercise, naturally, actually, your blood pressure goes up. And most of us think, no, high blood pressure is bad, but in exercise it’s actually really good because the more pressure inside your blood, that differential between the pressure in your circulatory system and the tissues is like a driving force that drives the oxygen out of the blood and into the tissues. we do EWAT, we’re taking advantage of all those physiological changes to allow us to take in oxygen very quickly and deliver it deeply into the tissues. in a 15 minute EWAT session, you could take in as much oxygen as you would in a hyperbaric session in 90 or more minutes. It’s really quite a large dose. Cheryl McColgan (21:09)Wow. then what about, so how does that affect the mitochondria? Does it just give them more energy and kind of helps them repair quicker? Or what’s the connection between mitochondrial health and the EY? Brad Pitzele (21:16)Thank This is actually the really fascinating part. And this is the thing that really got me more interested in it. EWAT was founded actually in the 1960s and 70s. There was this prolific inventor named Manfred von Arden. He was a German physicist and inventor. He invented the scanning electron microscope. He helped commercialize television technology in the 1930s. And he got interested in oxygen in 1960s and 70s because there was a gentleman named Warburg in the 1920s who had proven that he could take any cancerous cell, any regular cell and turn it into a cancerous cell simply by depriving it of oxygen. And the reverse was true. So Von Arden got interested in that, wanted to start experiment with oxygen, simply trying to reverse cancer. And along the way, what he discovered is something really powerful about our circulatory system, which is as we age, this thing we now refer to as inflammation happens inside our bodies, this slow, gradual increase in inflammation and that affects every part of our body including our circulatory system. But our circulatory system is actually kind of a weak link. At the very end of your circulatory system is your capillaries and they’re incredibly thin and they’re actually the component where the oxygen and the nutrients gets transferred from the circulatory system to the tissues. So you’ve got these really thin capillaries, thinner than a human hair, actually smaller than a red blood cell. In order for a red blood cell to get in a healthy capillary, it has to fold over like a taco to get in because it can’t fit in normal if it’s fully expanded. So there’s not a lot of room for error. And when you start having this inflammation, it causes blockages in the capillaries. So when that happens, you lose circulation downstream. You have what I call a brownout. All the cells on the other side of that inflammation are no longer getting red blood cells, they’re no longer getting oxygen. Luckily, our body does have a backup generator and that’s called anaerobic respiration. Anaerobic respiration is when they create energy without oxygen. But the problem with it is multi-fold. Number one, it only can produce about 5 % of the energy, it can produce what has oxygen. So immediately the cells are like powering down, they’re not able to do all of their essential functions. problem is it produces a massive amount of metabolic waste and free radicals and those things damage our mitochondria because our mitochondria are incredibly fragile as we spoke about earlier and they’re right at the heart of it wherever you’re producing energy you have some free radicals but now when you shift over to anaerobic all of a sudden you’re just spitting out all sorts of damaging chemicals if you will and it has no energy so it has no way to actually clear it and so it becomes I kind of call it’s like a doom loop, which is it starts with dysfunction the dysfunction causes more free radicals which causes more damage and dysfunction and Soon enough, you know, you’ve got these kind of almost zombie cells. They’re just having a hard time Doing anything and then when you do IWA what’s amazing is the oxygen because it’s Inside the plasma it can get through those blockages. So it immediately starts to feed those downstream cells the oxygen they’ve been starving but more importantly than that immediate fix if you will is they cause an anti-inflammatory effect and this was another like big aha in my healing journeys when I realized There’s plenty of research on this. Anywhere in your body you have inflammation, you have the hypoxia, which is the fancy medical term for oxygen starvation. So inflammation means local oxygen starvation. And anywhere you have oxygen starvation, you have inflammation. They go hand in hand. You can’t have one without the other. And so when we restore oxygen, even in the circulatory system, we can turn off that inflammation that’s happening in our capillaries, reestablish normal blood flow. So you get done doing your EWOT sessions. And Von Arden discovered this. had elderly people, he looked at their capillaries and their throughput, and he had them do just a couple sessions of EWOT, and they came back weeks later, and their microcirculation was still reestablished to more youthful levels. So he was able to open them back up where red blood cells were able to deliver oxygen. really at the root of it all is, you know, every chronic illness you can think of, it has inflammation. Right? mean, there’s not one Alzheimer’s, cancer, autoimmunity, the list goes on and on, name one and it has chronic inflammation. And there’s actually, there’s a gentleman, Arthur Guyton, he wrote the textbook, Medical Physiology, and every doctor any of us has ever gone to had to use that medical physiology book. when they went to medical school, it’s been the standard across the world for over 50 years. And he has this great quote where he says all disease at its root is lack of oxygen. And it’s really true because once the mitochondria break down and we start having inflammation, all the negative effects come from downstream from that. And so that was kind of my. Aha. Light bulb moment, which is if I can turn my mitochondria on it, and I can turn down the inflammation and eventually turn off the inflammation. then like my body will have energy to get ahead. can start to repair itself. It can start to detoxify the immune system. Then we’ll have energy to do everything it needs to do and help, you know, kind of kick on and start to fight a good battle, so to speak. Cheryl McColgan (26:58)Yeah, I mean, I want to go back to how this actually helped you and how you actually found one and all that stuff. But my brain is just going, the one thing that I keep coming to hearing your explanation, and that was an amazing explanation, by the way, for lay people, I can tell you’re an engineer or so. The system where you’re talking about going all the way to the capillaries, I heart disease is the number one killer, right? And we have, I think a lot of it is the chronic inflammation that you’re talking about, but. Obviously once that process is already done, you’re describing how the capillaries can’t get any red blood cells. So to me, it would make perfect sense that this might be not only did it help you in your disease process with Lyme disease and the arthritis and everything, but it seems like it would be pretty amazing for cardiovascular patients or people that don’t have good blood flow, like that on top of the mitochondrial benefit. Brad Pitzele (27:41)Hmm It’s actually, we are helping folks with everything from autoimmunity, cancer, Lyme, long COVID, chronic fatigue, Parkinson’s, heart disease, so many things, because if you can turn off the inflammation and you can give the body energy to heal, it will do just amazing things. That was kind of like the shocking thing to me when I first got into it. was like, wait a second. Like every time I was treating myself as a pin cushion and trying something new, I always had to the question like, what if this doesn’t work? and like what damage could I be doing? know, because there were things that were a little bit risky to be quite honest, where I found out risks, you know, a little bit too late for my liking. But this was one where was like, it’s oxygen. And like, so it was kind of shocking when I started looking at the benefits and I was like, this is kind of crazy that we’re talking about something as simple as oxygen with all these health benefits. But yeah, we’ve had folks with all sorts of different chronic cardiovascular conditions Cheryl McColgan (28:31)Right. Brad Pitzele (28:48)Now, there’s a lot of health benefits to it, but the other crazy thing about oxygen is there’s all these athletic performance benefits. And this is important because directly to your cardiovascular component, which is actually a lot of Olympic teams have used EWAT to improve their athletic performance. because athletic teams are very science driven, there’s some really good research on it showing it improves VO2 max, reduces recovery time. improves short-term memory, it improves power output, et cetera. And all of this is really due to being able to fuel our cells and our muscles more, and also helping clear out all that metabolic waste, because that metabolic waste primarily develops when you have a shortage of oxygen when you’re exercising. Cheryl McColgan (29:34)Amazing that something so simple could be so hugely beneficial. So once you finally saw this, you’re like, Werber knew this about cancer and this guy’s onto this exercise with oxygen thing. Like, well, how do you do it? Where do you get it? Like nobody’s ever seen this before. I think like you’re saying the athletic teams might have it and stuff, but I mean, I’ve certainly never been anywhere where I’ve seen like, hey, get EWOT therapy here. So how did you find it? Brad Pitzele (29:56)Yeah, it’s really, really kind of a rare thing. 15 years ago, it was incredibly rare. There really wasn’t anywhere to go. You could find it occasionally. You might find it in a chiropractor’s office here or there or some sort of recovery clinic. Nowadays, they’re more widespread. So there are places that do it, doctors, chiropractors. But for me, there were a couple of folks selling it, but they were… I didn’t have a whole lot of faith. There was no customer reviews. was no customers talking about it on chat. It was just them as the company and they, a lot of them spoke in superlatives and like marketing speak that it just didn’t make me feel really comfortable. And they were very expensive too. you know, they were maybe the cheapest was 5,000 and the most expensive one I saw was 25,000. and it was this kind of cross hatch of I didn’t have confidence and geez, that’s a lot of money for this next experiment when the last Cheryl McColgan (30:31)yeah. Brad Pitzele (30:49)26 behind me didn’t do anything or 57 or whatever it was. So that’s when I kind of decided, did a little bit more research and decided I was going to try to build my own. Cheryl McColgan (31:00)Yeah, was thinking that I was like, I was an engineer, the next thing would be like, can I just build this? So that’s what you did, obviously, right? Brad Pitzele (31:06)I did it out of necessity because I just didn’t have faith. I built my own. didn’t think it was, I’ll be honest, I didn’t think this was gonna be my solution. Nothing else was. And I started doing it and… You know, slowly but surely I started to walk out of that basement, that proverbial basement. I just kept taking steps up and up. At first it was subtle and then it was kind of all at once sort of thing where I was shocked. You know, was like things like, my gosh, my brain fog’s gone. I’m like focusing in a meeting or I just got down on the floor and played with the kids and I don’t need to lay in bed for two days in pain. And you know, slowly but surely I just felt better and better. And it wasn’t until I saw that same doctor again, and he was like, wow, you’re like a year later. And he was like, wow, you’re so much better. What did you do? And I told him, and he’s like, wow, would you consider selling them to my patients? And that was kind of the, you know, jumping off point where I was like, well, gosh, yeah, maybe we could help other people with this. Cheryl McColgan (32:04)Yeah, that’s awesome. I’m so glad, you know, it’s, it’s, it’s always an interesting thing on podcasts because sometimes you get, I think not on this particular podcast, but other ones, it’s like people that kind of are just selling stuff, you know, or snake oil things or whatever. But what I really love is when there are people that, you know, had their own health problem, they dive into the research, they try it all there, use themselves as an experiment as a pin cushion, as you said, and then they find something that actually works. And then they they make it so that they can share it with everybody else. don’t just keep it to yourself, because I’m sure it kind of felt like a miracle at the time if something finally worked for you. Brad Pitzele (32:41)You know, it really was. I was, because the hardest part is also when you’re in these groups and you’re talking to all these other folks and they’re like, oh, try this, nothing worked and then this worked. And you try that thing and it didn’t work. You you try 57 other different things, as I was saying, and you kind of just start losing any hope. You’re like, I don’t think, I think I’m just that case that there’s nothing that’s going to work. But yeah, when you do find it, it’s, yeah, it’s obviously life changing, even having hope and like, I always tell folks like when you’re really sick, it’s not about, you wanna get to 100%, like 100 % is amazing, it’s the dream we all have when we’re sick, but. more important than 100 % is like feeling better this week than last week or this month than last month because at some point when you’re in it, you just lose a lot of hope and it becomes kind of this like the spiral downward that you just don’t believe in anything and it just lowers you spiritually I just say. And having something to know like, hey, Yeah, it still kinda stinks, but like, remember a month ago it was worse, and so like, now you’re like, yeah, I can’t wait to see how I’m gonna be two months from now, you know, or where am gonna be by this summer sort of thing? Like, it was, it’s kinda the exact opposite. It’s kinda like this hope spiral, if you will. Cheryl McColgan (33:55)Yeah. Well, it’s kind of that’s something that I think it’s good to point out for people too, is that, you you mentioned there is all this research on this. There’s a lot of good science to back up mitochondrial health, that’s kind of mitochondrial health is kind of a long game. And it’s kind of something that you have to continually do not over, you know, just a few days and you’re going to feel so much better. It’s week after week, month after month, the more that you support your mitochondrial health, the more chance you have of really feeling better. So it’s not just this thing where you can try it for a week and you’re like, that doesn’t work. You have to keep up on it for a while, right? Brad Pitzele (34:24)Yeah. Yeah, you’re absolutely right in general speaking. mean, we have… people come to me and they ask like, how long am I going to have to do this for? I tell them is, I can’t say how long until you get to the top of the mountain, so to speak, but I find that most folks who get to the top of the mountain, they feel so good when they do it, they don’t ever want to stop. And some of those folks never really exercised, they hated it, but now they’re like, it’s like 15 minutes, I do it three or five times a week, and I feel amazing, so why wouldn’t I do it? And we talked about that capillary thinning, Cheryl McColgan (34:52)Mm-hmm. Brad Pitzele (34:58)That’s actually a chronic thing that happens to all of us in Western society. And so this is something that’s anti-aging at that very kind of cellular level. So I recommend it for folks, but. I guess for me when I was really sick, always say one of the hardest parts was the ceremony is this what they call them. Counting pills every night, doing this protocol, doing that protocol. You keep adding, like if there’s 10 more minutes in your day, you add 10 more minutes of some protocol that you’re hoping will make you feel better. And then you get to a point where you realize you’re spending six hours of your day, you know, just all you’re doing is these protocols and it just becomes overwhelming. like, even if I felt better, what’s the purpose of all I’m doing is going from from the sauna to the this and I’m doing this pill and I’m doing that. And that’s kind of the, what I found, one of the things I really loved about EWOD was it was something I could do consistently in my home, 15 minutes a day. And it helps with your mitochondrial health. It helps with detoxification. It helps with energy. So it’s like, multiple, it’s kind of multifaceted in the way it benefits you. relatively short period of time. Cheryl McColgan (36:07)Yeah, and you mentioned, and I want to be respectful of your time. know we’re kind of getting a little bit long here, but one of the other things when in respect to mitochondrial health is red light therapy. And there’s also a ton of great research on that. And so I kind of wasn’t surprised when I went to your website that that’s something that you also got into. I mean, I think that’s when you look at the number and the breadth of research on that, I think it’s pretty undeniable that it is good for people that serves a real purpose, that it does help the mitochondria. So at what point, Brad Pitzele (36:34)Yeah. Cheryl McColgan (36:35)after you found the EWAT, I’m assuming you kind of got on this mitochondrial health thing and then maybe stumbled into that stuff. that how it went or is there something else? Brad Pitzele (36:44)Yeah, I started looking at it early on, probably about six months after I was doing EWOT, four to six months right in there I’d say, I started doing Red Light. So you’re right, there’s like tens of thousands of peer-reviewed research studies out there and what it does. They work really interestingly together. Because we mentioned EWAT, when you do it, you increase the supply of oxygen massively, right? It’s a day of oxygen in 15 minutes. So you’re flooding your body with oxygen. And then if you do red light immediately afterwards, what it does is the way it primarily works is it increases oxygen demand in your mitochondria. So it forces the mitochondria to suck up more oxygen. And when they do that, they produce more energy. So any of the research you read on red light whether skin health collagen growth bone mental, brain health, me, athletic recovery performance, healing in general, it all comes from the same thing, is that it’s just forcing our mitochondria to suck up more oxygen and produce more energy. So if you compare those two, you compare them at the same time, you first drive a massive increase in supply of oxygen, and then you increase the mitochondrial demand for it, and so you get this kind of one-two punch. The interesting thing is why I think we need it in today’s society as well is we’re actually deficient on red and near infrared light. And the reason is, if you look at the sun, the sun is full spectrum. has everything from ultraviolet and the blues through the reds and the near infrareds. So when you go outside and it changes throughout the day, early and late in the day, you get more of those reds and near infrareds. And at high noon, you get more of the blues. unfortunately, or fortunately, however you want to look at it, over time as as ⁓ species, we’ve moved indoors and we started using indoor lighting primarily and we spend more and more time there. And then more recently, we’ve switched from incandescent to LED lighting. Now, LED lighting is very energy efficient and one of ways they make it incredibly energy efficient is they take out all the reds and the near infrareds that we experience as heat because obviously you don’t want your lighting to heat your room. You don’t want it to, everyone sees that as energy. waste and to that extent you’re trying to use it for lighting it can be. However, that puts us in a place where we spend a lot of time bathed in blue lights and not really getting enough of the reds and the other parts of the spectrum. Cheryl McColgan (39:27)Yeah, that’s another interesting rabbit hole for people to go down if they haven’t already is just the, you know, changing out some of the lighting in your home or using specific lighting for certain scenarios, like in your bedroom and towards night as you’re getting ready to go to sleep. But anyway, I just want to clarify one quick point there, because I’m envisioning, that was actually what I was envisioning when you started talking about the synergy between red light and the EWAT. So do you like do your EWAT with the red light panel like in front of you or do you just do it right after? Brad Pitzele (39:53)Yeah. I prefer to do it right after. The challenge with doing it right on you is to get the best benefit from red light. Red light works on something called a biphasic dose response, fancy science term, which just means the benefits over time look like a bell curve. So too little, you won’t get any benefit. There’s kind of like a just right where you get peak benefit. And then if you do more, it starts diminishing in benefit. It doesn’t harm. It’s just a waste of time, right? So you spent five more minutes to get less sort of thing. Cheryl McColgan (40:21)Mm-hmm. Brad Pitzele (40:22)with exercising in red light is one, I like to get as much skin exposure as possible so you’re hitting as many mitochondria as possible. And two is you’re moving. So sometimes you’re close to the light, sometimes you’re further away. And so you’re not really able to kind of measure that dose effectively to get inside that biphasic kind of peak zone. Cheryl McColgan (40:43)Okay, no, that makes a ton of sense. Although I still am going to put this out to you that, maybe you put at least on, you know, the little face mask while you’re exercising. I feel like you can attach it to the oxygen part, you know, and just put a red light around it. Maybe that’s a little too, maybe that’s a little too much. But anyway, well, Brad, this has been so wonderful. And I just appreciate you so much sharing your whole journey and then how you came to find this. Brad Pitzele (40:51)There you go. It makes yours waterproof. That’d be fun. Cheryl McColgan (41:09)If people want to connect with you online or learn more about EWOT and learn more about Red Light, where’s the best place that they can find you and connect with you? Brad Pitzele (41:17)Yeah, go to 1000roads.com slash Cheryl and we have a great offer for your listeners. They can check out. You can also ⁓ go to our YouTube channel. put out weekly videos. 1000roads, HQ is our channel. It’s all spelled out, O-N-E-T-H-O-U-S-A-N-D-R-O-A-D-S.com. Cheryl McColgan (41:25)Awesome. Okay, awesome, and all that will be in the show notes for everyone, so don’t feel like you have to write it down. But Brad, again, thank you so much for coming and sharing your knowledge today, and I really appreciate it. Brad Pitzele (41:46)Thank you so much, Cheryl.

On today's show, Pat, Darius Butler, AJ Hawk and the boys recap WrestleMania 42 as Pat is showing the effects from Saturday night after being brutalized by Jelly Roll, Cody Rhodes, and Randy Orton. They also cover the NBA and NHL Playoffs in full swing, and the NFL Draft being just a few days away. They are also joined by several great guests including ESPN Senior NFL Insider Adam Schefter; former CMO and BMO of the NFL, and current CEO of the PGA Tour, Brian Rolapp; Super Bowl Champion, 4x Pro Bowler, 3x All-Pro, Walter Payton Man of the Year, and analyst for Thursday Night Football on Prime, Andrew Whitworth; 11 year NBA veteran, NBA Champion, and current NBA analyst on ESPN, Iman Shumpert; and lastly, former NFL team doctor, and host of the Sports Injury Central podcast, Dr. David Chao. Make sure to subscribe to youtube.com/thepatmcafeeshow or watch on ESPN (12-2 EDT), ESPN's Youtube (12-3 EDT), or ESPN+. We appreciate the hell out of all of you, We'll be off tomorrow, but we'll be LIVE from the Draft Spectacular set in Pittsburgh on Wednesday. Cheers. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this week's episode we discuss some of the latest news around the MLB, including the Brewers and Phillies clinching playoff berths and highlight the struggles of the New York Mets that can cost them a chance at the postseason. Georgio also returns to recap the second week of the NFL season and dive into multiple Fantasy Football topics.Chapters:0:00 - Intro02:20 - MLB Updates06:15 - Thursday Night Football, Commanders @ Packers 15:43 - Week 2 Day Slate Recap56:10: Sunday Night Football, Falcons @ Vikings 59:25: Monday Night Football, Bucs @ Texans 1:08:37: Monday Night Football, Chargers @ Raiders 1:14:40 - Week 3 Predictions1:23:32 - Fantasy Football Talk1:30:55 - Week 3 Waiver Wire Targets 1:37:00 - Panic Levels After Week 21:40:15 - Podcast ParlayFollow us on TikTok here:https://www.tiktok.com/@figuresofsport?_t=zp-8xqbk0xjbbr&_r=1Follow us on Instagram here: https://www.instagram.com/figuresofsportmedia/All audio versions of the podcast are available here:https://linktr.ee/figuresofsport

Learn about the Forest Service Reorganization on the USDA's website.Learn more about KVMRx online and sign up to play on Skream Radio here.

This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure. Four years cancer-free. Dave breaks down the mechanistic basis for oncolytic virotherapy—why cancer cells can't mount antiviral defenses that healthy tissue can—and the regulatory tension between patient autonomy and FDA gatekeeping on experimental immunotherapies. This is either a triumph of DIY biohacking or a cautionary tale about biosafety; either way, oncolytic virotherapy is accelerating toward mainstream clinical use and forcing a reckoning about access to cutting-edge cancer immunology. Sources: -https://www.dana-farber.org/newsroom/news-releases/2026/virus-based-therapy-boosts-anti-cancer-immune-responses-to-brain-cancer -https://www.eurekalert.org/news-releases/1116087 -https://acgtfoundation.org/news/oncolytic-virus-therapy-for-cancer/ ***Spermidine is the Missing Link Between Fasting and Longevity*** A Nature Cell Biology study across yeast, flies, mice, and humans reveals that fasting triggers longevity exclusively through spermidine—blocking spermidine synthesis ablates every lifespan-extending benefit, cardioprotection, and anti-inflammatory outcome, even with identical caloric restriction. Dave explains why your intermittent fasting protocol is metabolically inert without spermidine, the specific foods highest in bioavailable spermidine (wheat germ, aged cheddar, shiitake mushrooms, fermented foods), and how to time supplementation for maximum autophagy activation. This is the most critical missing variable in fasting-focused biohacking that almost no one is tracking. Sources: -https://www.nature.com/articles/s41556-024-01468-x -https://pubmed.ncbi.nlm.nih.gov/39117797/ -https://oxfordhealthspan.com/blogs/aging-well/spermidine-and-healthy-aging-insights-from-a-2026-nature-review -https://www.glp-1.science/blog/spermidine-autophagy-supplement/ ***Hair Regrowth Breakthrough: SHH-Mimetic Peptides Replace Minoxidil*** Topical peptides mimicking sonic hedgehog signaling (the embryonic pathway that initiates hair follicles) activate dermal papilla stem cells and deliver 65% hair regrowth at 24 weeks versus 40% with minoxidil—with zero systemic absorption and zero cardiovascular risk. Dave covers why minoxidil's vasodilation mechanism is crude (and why it triggers tachycardia and hypertrichosis), how SHH-mimetic peptides directly target the actual biological lever (stem cell activation), and why this mechanistic upgrade should reshape hair loss treatment within 12 months. This is precision medicine applied to cosmetic optimization. Sources: -https://finance.yahoo.com/sectors/healthcare/articles/goodbye-minoxidil-clean-bio-hacking-150800494.html ***"Sardinemaxxing": $1.39 Per Can Delivers 370% B12, 982mg Omega-3s, 96% Selenium*** Canned sardines are experiencing a viral surge on TikTok (#sardinemaxxing: 90,000+ videos) because a single 100-gram serving packs 370% daily B12, 982mg omega-3s, 96% selenium, and 24% vitamin D—all for $1.39. Dave breaks down the nutrient density to cost ratio (superior to wild salmon, fish oil supplements, and selenium stacks), the anti-inflammatory mechanisms (B12 methylation support, selenium-dependent glutathione peroxidase, omega-3 IL-6/TNF-α reduction), and why this represents a biohacker's efficiency play: maximum micronutrition per dollar with zero processing overhead. The shift from complexity back to simplicity. Sources: -https://news.northeastern.edu/2026/04/08/what-is-sardinemaxxing/ ***Fluoride in Community Water Has No Effect on IQ or Cognition — Wisconsin Longitudinal Study*** A seven-decade Wisconsin study tracking 10,317 people from age 16 through 80 finds zero evidence that community water fluoridation (0.7 mg/L, the U.S. recommended level) reduces IQ, impairs cognition, or causes neurotoxicity at any life stage. Dave distinguishes between community-level fluoridation and high-endemic-fluoride regions (2–10 mg/L in parts of Asia), clarifies why the anti-fluoridation narrative became culturally dominant without robust U.S. epidemiological data, and examines why 17+ states reversed fluoridation policy based on flawed evidence transfer. This is a case study in how folklore—even with mechanistic rationale—can override data. Individual choice about fluoride exposure remains valid; cognitive toxicity at community water levels is not supported. Sources: -https://www.sciencenews.org/article/fluoride-drinking-water-iq-no-evidence -https://www.nbcnews.com/health/kids-health/fluoride-water-children-iq-brain-cognition-study-rfk-jr-rcna267328 -https://studyfinds.com/major-study-finds-no-link-between-fluoride-water-lower-iq/ -https://medicalxpress.com/news/2026-04-fluoride-kids-iq-decades-analysis.html -https://jamanetwork.com/journals/jamapediatrics/fullarticle/2828425 -https://ntp.niehs.nih.gov/research/assessments/noncancer/completed/fluoride This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immunotherapy breakthroughs, fasting optimization, cosmetic stem cell activation, nutrient density efficiency, and evidence-based policy reversals. Host Dave Asprey connects emerging clinical research, decade-long epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and distinguishing mechanistic wins from folklore-driven narratives. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: oncolytic virus therapy cancer, measles VSV immunotherapy, DIY biohacking immunotherapy, regulatory gatekeeping cancer treatment, spermidine fasting autophagy, spermidine longevity, intermittent fasting mechanism, wheat germ aged cheddar spermidine, SHH sonic hedgehog hair growth, dermal stem cell activation hair, minoxidil replacement peptide, hair regrowth mechanism, sardinemaxxing TikTok, sardines omega-3 B12 selenium, nutrient density cost ratio, nutrient bioavailability supplements, fluoride IQ study Wisconsin, community water fluoridation safety, fluoride high-exposure risk, anti-fluoridation evidence, biohacking news 2026, longevity research, mechanism-driven biohacking, performance optimization, healthspan extension Thank you to our sponsors! - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. -iRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com/DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Virologist Self-Cures Cancer 02:41 – Fasting & Spermidine 04:22 – Hair Loss: Beyond Minoxidil 06:08 – Sardines as a Supplement Stack 07:43 – Fluoride & IQ: The 70-Year Study 09:47 – Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Full show broadcast features Sal Capaccio & Chris Trapasso talking all things Buffalo Bills, NFL draft, NFL schedule nuggets, draft prospects, sneak peaks & so much more. Terrible Time Timmy has his take of the day. Gene passes out shots, plus last call is for you.

Fatty liver and insulin resistance form a dangerous loop driving diabetes, dementia, and colon cancer. Learn what causes this cycle, what happens when it keeps running, and how diet, fasting, the Mediterranean diet, and targeted supplements can break it for good. FEATURED PRODUCT The Good Poops Protocol — combining Liver Boost, Gut Powder, and Berberine Plus — directly targets both sides of the fatty liver and insulin resistance loop discussed in this episode. Liver Boost supports your liver's ability to process fats and manage detoxification, Berberine Plus has been shown to improve insulin sensitivity and lower pro-inflammatory cytokines, and Gut Powder addresses the digestive consequences — bloating, constipation, and gut dysfunction — that compound when this loop goes unchecked. Together, these three work on the liver, the blood sugar, and the gut simultaneously, which is exactly what this episode makes clear you need.

Dr. Jeffrey Bland, Founder and President of the Personalized Lifestyle Medicine Institute and President of Big Bold Health, is described as the “godfather of functional medicine.” He details the origins of functional medicine as a systems-biology, root-cause approach emphasizing diet, lifestyle, and supplements alongside conventional allopathic care, especially for chronic disease. Bland contrasts medication “number needed to treat” examples (statins and TNF-alpha blockers) with personalized lifestyle interventions, noting adherence challenges. He discusses GLP-1 weight-loss drugs as a major pharmacologic advance but raises concerns about long-term effects, discontinuation rates, side effects, and inadequate nutrition if food intake drops. Bland describes research on bitter compounds and gut “taste” receptors influencing GLP-1 and related hormones, links to Blue Zone diets, and introduces Big Bold Health's Himalayan Tartary Buckwheat and minimally processed, sustainably sourced fish oil products, the Omega-3 index, and targeted formulations with lutein/astaxanthin, plus ongoing clinical trials on immune aging and gene expression.

On this episode of The Jon Gordon Podcast, I sit down with Hall of Fame NFL athletic trainer and sports medicine expert Mike Ryan for an inspiring conversation that's filled with wisdom, stories from the NFL sidelines, and practical ways to stay healthy from his new book Foam Rolling made Easy.   Mike shares his unique journey—from his early days as an assistant with the New York Giants to becoming the youngest head athletic trainer in the NFL with the Jacksonville Jaguars, and later transitioning to his current role with NBC's Sunday Night Football. Along the way, Mike opens up about the leadership lessons he learned under pressure, the importance of clear communication, and the power of honesty in building trust with both players and coaches.   We delve into the mindset shifts required when stepping into a leadership role, the art of mentoring others to their own success, and the lasting impact of fostering a culture where team members can grow and thrive. Mike's commitment to making sports medicine simple and accessible shines through as he discusses his mission to help people move pain-free and live more active, fulfilling lives. He unpacks strategies for injury prevention, reveals how foam rolling can unlock your body's potential, and explains why taking care of ourselves matters—not just for elite athletes, but for anyone who wants to stay "stronger for longer."   Whether you're a leader, an athlete, or simply someone looking to invest in your health, this episode is packed with actionable advice and encouragement. Mike's passion is contagious, and his message is clear: no matter your age or where you're starting from, positive change and lifelong wellness are within your reach. About Mike, Mike Ryan is a sports medicine specialist, physical therapist and former 26-year National Football League (NFL) Head Athletic Trainer/Physical Therapist. He proudly served as President of the PFATS Research & Education Foundation for 14 years. Mike was recently inducted into the NFL Athletic Trainers Hall of Fame as a member of the Class of 2026. He's focused his career post-NFL career on teaching individuals the art of restoring pain-free joint movement without medicine. Mike's Personal Mission Statement is simple: To Enhance the Health of Others and Himself Mike is the currently the sideline Sports Medicine Analyst for both Sunday Night Football and Thursday Night Football. Mike's second book, Foam Rolling Made Easy, was released in January 2026. His athletic and extreme-sport resumes continue to grow: • Acrobatic plane Wing Walking • Competing in 3 of the last 4 three DekaFit World Championships • 6 Ironman triathlons in 5 countries • Great white shark diving in South Africa • Bungee jumping in New Zealand • Two Running with the Bulls in Spain • 2002 Duathlon World Championships • Ironman Triathlon World Championships Mr. Ryan attended Central Connecticut State University earning hisdegree in Athletic Training before earning hisPhysical Therapy degree from the University of Connecticut.  Here's a few additional resources for you… Do you feel called to share your story with the world? Check out Gordon Publishing  Follow me on Instagram: @JonGordon11 Check out my new revised release of my book, The Power of Positive Leadership here! Every week, I send out a free Positive Tip newsletter via email. It's advice for your life, work and team. You can sign up now here and catch up on past newsletters. Ready to lead with greater clarity, confidence, and purpose? The Certified Positive Leader Program is for anyone who wants to grow as a leader from the inside out. It's a self-paced experience built around my most impactful leadership principles with tools you can apply right away to improve your mindset, relationships, and results. You'll discover what it really means to lead with positivity… and how to do it every day. Learn more here! Do you feel called to do more? Would you like to impact more people as a leader, writer, speaker, coach and trainer? Get Jon Gordon Certified if you want to be mentored by me and my team to teach my proven frameworks principles, and programs for businesses, sports, education, healthcare!

Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided for informational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Dr. Deb Muth 57:54Your use of information from this broadcast is entirely at your own risk. By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.

Taylor Rooks is a two-time Emmy Award–nominated journalist and producer who currently hosts NBA on Prime Video and Thursday Night Football on Prime. In addition to being one of the most important voices in sports media, she's the founder of the Taylor Rooks Foundation—an organization that supports communities by providing school supplies to teachers, helping people pay their utilities during the holidays, and more. On this episode, Rooks dives into why she believes both hard work and luck are necessary for success, her favorite on-air looks she's worn over the years, and the ways she advocates for herself financially. 

The Hidden Causes of Autoimmune Disease (Dr. Arland Hill) — How to Reverse It: RWP6.  Dr. Arland Hill is a Functional Medicine Clinician and Author of "Platform Food, Function, Freedom.com."  Dr. Hill has an in depth conversation with Dr. Ben Weitz about Autoimmune Diseases. Dr. Arland Hill explains the primary reasons why there has been an increase in the rate of autoimmune diseases in the United States. The mass food production has significantly altered what is now classified as food as compared to that prior to the 1940's. The combination of drastic changes in our diet and increased toxin exposure in a post-industrialized society has contributed to the rise in autoimmune disease. An important variant is the effect of stress.  Stress breaks down the body's systems, which can create dysregulation in the immune system. This opens the door for leaky gut syndrome and can manifest in autoimmune issues. Environmental and food toxins coupled with increased stress levels can be the perfect breeding ground for autoimmune diseases to develop. However it is important to note that each of these individual factors can cause autoimmune disease to manifest on their own. Western medical doctors treat diseases by providing medications that suppress the immune system such as corticosteroids, chemotherapy agents and newer injectables.  TNF alpha blocking agents like Humira and Remicade block the immune system, which is needed to maintain homeostasis, fight off and prevent the disease processes from beginning.  These drugs have very serious side effects that include depressing the immune system and worsening the effects of infections and cancer. The Functional Medicine approach treats autoimmune diseases by looking at the underlying factors that lead to the immune system being deregulated. These factors can include disease processes such as leaky gut, food sensitivities, toxins, mold, heavy metals, nutritional deficiencies, infections, etc.  Functional Medicine looks at the best strategies for correcting this by identifying the cause and catalyst of those agents. Once you identify the cause and remove the factors that negatively affect the G.I. and immune system, a strategy to intervene can be formed. A nutritional strategy to repair and restore the gut is recommended. By reestablishing the mucosa tolerance and re-balancing the bacterial landscape, gut health is rebuilt and the immune system can function and respond unimpaired. The podcast will cover these topics in more depth and detail. You will learn more about how toxins behave. For example, how BPA and heavy metals found in plastics insert itself in the metabolic pathway and disrupt it by misplacing nutrients. You will also learn how to test for autoimmune disease and learn the role infections play in increasing our risk. More importantly, you will learn how to improve your health and nutritional deficiencies.   Dr. Arland Hill can be reached at Dr.ArlandHill.com   Dr. Ben Weitz is also available for nutrition consultation by calling his office at 310-395-3111.

Rich ponders what's next for Seahawks QB Sam Darnold after leading Seattle to a Super Bowl LX win. Sportscasting legend/Thursday Night Football announcer Al Michaels joins Rich in-studio where they debate the all-time best 1-yard line plays in Super Bowl history, revisit the turning point that propelled the Seahawks to the Super Bowl, recounts announcing John Madden's final game before he retired from TV, shares his fondest memories from calling the unforgettable Miracle on Ice USA vs Soviet Union 1980 Olympic hockey semifinal, and more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

"Yeah, your question was better." Al Michaels joins the show to discuss his greatest call of all-time, the upcoming Super Bowl, his season on Thursday Night Football, and cryptocurrency. Plus, the Pitch Clock has returned with tons of off-season moves over the last week, and Adnan Virk is here to break it all down as Chris and Jeremy battle it out in trivia. Learn more about your ad choices. Visit podcastchoices.com/adchoices

1.29.26, John Ourand from Puck News joins The Kevin Sheehan Show to discuss how the NFL Playoff ratings are affecting the networks and if Al Michaels will be returning to Thursday Night Football next season.

1.29.26 Hour 2, Kevin Sheehan gets more caller thoughts on which all time NFL coach would they pick to win a Super Bowl in one year with a good roster. John Ourand from Puck News joins The Kevin Sheehan Show to discuss how the NFL Playoff ratings are affecting the networks and if Al Michaels will be returning to Thursday Night Football next season. Kevin Sheehan talks about Myles Garrett sending cryptic posts on social media and the Browns hiring Todd Monken.

Rich weighs in on Tom Brady's reaction to Bill Belichick's Pro Football Hall of Fame snub. Thursday Night Football Analyst Andrew Whitworth and Rich discuss Bill Belichick shockingly not being inducted into the Pro Football Hall of Fame on his first ballot, Matthew Stafford and the Los Angeles Rams' next steps after their heartbreaking loss in the NFC Championship Game, the Chicago Bears' bright future with the Caleb Williams-Ben Johnson head coach/quarterback pairing, and explains why the Seattle Seahawks will “handle business” against the New England Patriots in Super Bowl LX. O'Shea Jackson Jr. stops by the studio ahead of taping the latest episode of the ‘No-Contest Wrestling' podcast. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Fantasy Football show for Dec 19, 2025. Semifinals are underway! TNF reactions and Week 16 matchup previews! Get advice for the tough start/sit decisions in your fantasy football lineups. Plus, injury updates and the Wheel of SHAME! Manage your redraft, keeper, and dynasty fantasy football teams with the #1 fantasy football podcast.(00:00) Intro(00:30) Thursday Night Recap(09:20) Footclan Friday(10:10) NFL News(20:05) Fantasy Forecast(20:30) Vikings at Giants(27:20) Buccaneers at Panthers(32:45) Jacksonville at Broncos(40:50) Falcons at Cardinals(45:00) Steelers at Lions(50:30) Raiders at Texans(54:25) Patriots at Ravens(58:35) 49ers at ColtsConnect with the show:Subscribe on YouTubeVisit us on the WebSupport the ShowFollow on XFollow on InstagramJoin our Discord Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Simms is back after spending last Thursday in the owner's box in Tampa living the high life. The Dolphins made the right call on benching Tua for Quinn Ewers at this point. Simms would be worried if he were a Bengals fan about Joe Burrow's comments. Plus, his best bets of the week including a big Thursday Night Football match between the Los Angeles Rams and Seattle Seahawks. Go to https://OmahaSteaks.com to get 50% off sitewide during their Sizzle All the Way Sale. And use code GODBLESS at checkout for an extra $35 off. Minimum purchase may apply. See site for details. A big thanks to our advertiser, Omaha Steaks! Learn more about your ad choices. Visit megaphone.fm/adchoicesSee omnystudio.com/listener for privacy information.

In his update, Stugotz informs everyone that the Chicago Bears are reportedly flirting with a move to Indiana, before talking about how his phone took an unexpected dive into his pool, sending him into full-blown panic mode. Meanwhile, Quinn Ewers is named the Dolphins' starter and wasted no time promoting his official merchandise (The Stugotz is strong in you, Quinn). Plus, the crew tries to make sense of tonight's Thursday Night Football matchup between two 11-3 teams, the Rams and the Seahawks, and what kind of game it really is. Learn more about your ad choices. Visit megaphone.fm/adchoicesSee omnystudio.com/listener for privacy information.