Podcasts about all cause

In this episode of the Movement Logic Podcast, Sarah explores the commonly held belief that any amount of exercise is better than none. Using recent research, she discusses the benefits of minimal exercise on cardiovascular health and longevity but also highlights the limitations of this advice. She emphasizes the need for strength training and power exercises to meet the comprehensive physical needs of the body, especially as we age. Additionally, she discusses the socioeconomic barriers to regular exercise and suggests systemic changes to make meaningful physical activity more accessible to everyone.Sign up for the Wait List for our Bone Density Course!00:03 The Common Exercise Advice: Just Do Something02:01 Scientific Evidence Supporting Minimal Exercise06:58 Limitations of Minimal Exercise10:01 Strength Training and Its Importance16:35 Challenges and Practical Solutions for Exercise22:12 Conclusion and Final ThoughtsReferences:Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysisPhysical Activity, All-Cause and Cardiovascular Mortality, and Cardiovascular DiseaseAssociation of wearable device-measured vigorous intermittent lifestyle physical activity with mortalityResistance Training and Mortality Risk: A Systematic Review and Meta-AnalysisEffects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis

We're bringing back a listener favorite! And it's our first one of 2025! In today's episode, we are sharing three new nutrition studies. Are there really microplastics in gum, and if so, why? The foods that you can add to your diet that may counteract the effects of microplastics in the body. And, could weekend warriors be just as healthy as regular exercisers? You'll be surprised!    Studies Mentioned:   Chewing gums: Unintended sources of ingested microplastics in humans   Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective Association of Accelerometer‐Derived Physical Activity Pattern With the Risks of All‐Cause, Cardiovascular Disease, and Cancer Death   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions

We're bringing back a listener favorite! And it's our first one of 2025! In today's episode, we are sharing three new nutrition studies. Are there really microplastics in gum, and if so, why? The foods that you can add to your diet that may counteract the effects of microplastics in the body. And, could weekend warriors be just as healthy as regular exercisers? You'll be surprised!    Studies Mentioned:   Chewing gums: Unintended sources of ingested microplastics in humans   Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective Association of Accelerometer‐Derived Physical Activity Pattern With the Risks of All‐Cause, Cardiovascular Disease, and Cancer Death   Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions

Ohje, wir haben leider schlechte Neuigkeiten für alle, die sich schon auf den ein oder anderen Aperol oder Radler diesen Sommer gefreut haben. In dieser Folge haben wir uns die Empfehlungen der #WHO und #DGE angeschaut und diese besagen „nur 0 Promille sind risikofrei“. Die Gesundheitsmythen, dass ein Gläschen Rotwein zum Beispiel sogar gut für das Herzkreislaufsystem seien, sind überholt. Ganz im Gegenteil - rund 200 Krankheiten inklusive 7 Krebserkrankungen stehen in direktem Zusammenhang mit Alkoholkonsum!! Eine enorme Belastung für das Gesundheitssystem, aber eben vor allem für die Gesundheit. Das hat auch der noch aktuelle Gesundheitsminister Kar Lauterbach zuletzt in einem Podcast berichtet. Aber der möchte sich das Weintrinken (zumindest vorerst) nicht abgewöhnen… Instagram: AMS_Podcast Email: aufmessersschneidepodcast@gmail.com Liken nicht vergessen! Am 17.04. gehts mit spannenden Themen weiter. Quellen: Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults https://pubmed.ncbi.nlm.nih.gov/28818200/ ESC 2016 Abstracts Heberg et al. Low to moderate alcohole consumption ist not associated with a reduction in cardiovascular events – The danish nurses' cohort study; Golan et al. The effect of moderate wine intake on carotid atherosclerosis in type 2 diabetes; a 2-jear intervention study Genuss mit Folgen Nur eine Mini-Alkoholdosis schützt das Herz https://link.springer.com/article/10.1007/s15034-017-1216-x?utm_source Statistik Alkoholkonsum in Dtl. BGM https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/a/alkohol.html#:~:text=Durchschnittlich%20werden%20pro%20Kopf%20der,Tendenz%20im%20Alkoholkonsum%20zu%20registrieren. DGE Alkoholkonsum https://www.dge.de//fileadmin/Bilder/wissenschaft/referenzwerte/DGE-Position_Alkohol_EU_2024_10.pdf Alkoholkonsum Stiftung Gesundheitswissen https://www.stiftung-gesundheitswissen.de/alkohol/allgemeines https://pmc.ncbi.nlm.nih.gov/articles/PMC9677535/ Neudefinition von Alkohol WHO https://www.who.int/europe/de/news/item/02-10-2024-redefine-alcohol--who-s-urgent-call-for-europe-to-rethink-alcohol-s-place-in-society 
IARC Group 1 https://en.wikipedia.org/wiki/IARC_group_1 Direkte volkswirtschaftliche Kosten durch schädlichen Alkoholkonsum in Deutschland im Jahr 2022 https://de.statista.com/statistik/daten/studie/1458509/umfrage/direkte-volkswirtschaftliche-kosten-durch-schaedlichen-alkoholkonsum/ Behandlungsfälle Krankenhaus Alkohol https://de.statista.com/statistik/daten/studie/73745/umfrage/im-krankenhaus-behandelte-faelle-von-alkoholmissbrauch/ Alkohol führt zu vielen Gewalttaten https://www.aerzteblatt.de/archiv/alkoholbezogene-aggression-9444c5b4-1bae-4956-9cbe-fc3216d14b1b Umgang mit alkoholisierten Patienten https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1276795 Effect of alcohol consumption on diabetes mellitus: a systematic review https://pubmed.ncbi.nlm.nih.gov/14757619/ kognitive Reserve https://de.wikipedia.org/wiki/Kognitive_Reserve?utm_source= WHO Zu globalem Alkoholkonsum https://www.who.int/news-room/fact-sheets/detail/alcohol Resveratrol https://pmc.ncbi.nlm.nih.gov/articles/PMC6804046/ https://pmc-ncbi-nlm-nih-gov.translate.goog/articles/PMC2359620/?_x_tr_sl=en&_x_tr_tl=de&_x_tr_hl=de&_x_tr_pto=rq Suchtbeauftragte Landesärztekammer https://www.laekh.de/ueber-uns/ombudspersonen/drogen-und-suchtbeauftragte

This episode of Walk, Don't Run to the Doctor emphasizes the importance of building and maintaining a healthy microbiome for better health outcomes, disease prevention, and overall well-being. The microbiome, a complex population of microorganisms living in the gut, plays a significant role in protecting against cancer, regulating digestion, and supporting various metabolic and immune functions. A home-cooked diet, particularly a whole food omnivorous diet rich in fiber and fermented foods, helps to cultivate a resilient microbiome. Exercise, scant to moderate alcohol consumption (especially wine), and avoiding sugar, refined flours, and artificial sweeteners further enhance gut health. This episode also warns against overuse of antibiotics and reliance on probiotic supplements, advocating instead for a food-based approach through diet and lifestyle changes. Key Takeaways: Microbiome's Role in Health: The microbiome impacts everything from cancer prevention to appetite regulation, insulin sensitivity, immune function, and even brain health. Diet and Gut Health: A Mediterranean-style, omnivorous whole food, diet improves microbiome diversity and overall health, reducing risks for conditions like obesity, diabetes, and cancer. Fermented Foods: Incorporating fermented foods like yogurt, kefir, and kombucha supports a healthy microbiome and reduces cancer risk. Exercise and Lifestyle: Regular exercise promotes gut health and boosts immunity, while avoiding sugar, artificial sweeteners, and unnecessary antibiotics helps maintain microbiome balance. Natural Approach: The podcast recommends focusing on diet and lifestyle over probiotic or prebiotic supplements to build a resilient microbiome. For more insights and advice on reducing dependence on medications through lifestyle changes, make sure to subscribe to Walk, Don't Run to the Doctor. More references can be found at www.GreatMed.org Would you like Dr. Hassell to answer your question on the air?  Contact us! Phone/text: 503-773-0770 e-mail: info@GreatMed.org Write us a letter.  We love to hear from you.  This podcast is sponsored by our generous listeners.  Send questions, comments, and support to: 4804 NW Bethany Blvd., Suite I-2, #273 Portland OR 97229 References:           Zhang, X., et al. (2023). Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights form the BE GONE trial. The Lancet, 98:104873. https://doi.org/10.1016/j.ebiom.2023.104873            Diez-Ozaeta, I. & Astiazaran, O. (2021). Fermented foods: An update on evidence-based health benefits and future perspectives. Food Research International, 156. https://doi.org/10.1016/j.foodres.2022.111133            Perler, B., et al. (2023). The role of the gut microbiota in the relationship between diet and human health. Annual Reviews in Physiology, 85:449-68. https://doi.org/10.1146/annurev-physiol-031522-092054            DeVos, W., et al. (2022). Gut microbiome and health: mechanistic insights. Gut-BMJ, 71:1020-1032. doi: 10.1136/gutjnl-2021-326789            Kim, J., and Le, H. (2022). Potential role of the gut microbiome in colorectal cancer progression.  Frontiers in Immunology, 12: 807648. doi: 10.3389/immu.2021.807648            Pyo, Y., et al. (2024). Probiotic functions in fermented foods: Anti-viral, Immunomodulatory, and anti-cancer benefits. Foods, 13:2386. https://doi.org/10.3390/foods13152386            Zhang, K., et al. (2019) Fermented dairy foods intake and risk of  cancer. International Journal of Cancer, 144: 2099-2108.            Michels, K. B., et al. (2020). Yogurt consumption and colorectal cancer incidence and mortality in the Nurses' Health Study and the Health Professionals Follow-Up Study. The American journal of clinical nutrition, 112(6), 1566–1575. https://doi.org/10.1093/ajcn/nqaa244            Shams-White, M., et al. (2022). The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk: A Longitudinal Analysis in the NIH-AARP Diet and Health Study, Current Developments in Nutrition, Volume 6, Issue 6, nzac096,ISSN 2475-2991,https://doi.org/10.1093/cdn/nzac096.            Rad, A., et al. (2021). Postbiotics as promising tools for cancer adjuvant therapy. Advanced Pharmaceutical Bulletin, 11(1), 1-5. https://apb.tbzmed.ac.ir            Sharma, A., et al. Final results of a phase I/II study to investigate efficacy of a high potency multistrain probiotic on chemo induced diarrhea. ESMO, 29(8). Doi:10.1093/annonc/mdy424            Luceron-lucas-Torres, M., et al. Association between wine consumption and cancer: a systematic review and meta-analysis. Frontiers in Nutriition, 10:1197745. doi: 10.3389/fnut.2023.1197745            LeRoy, C., et al. (2020). Red  Wine Consumption  Associated with increased gut microbiota a-diversity in 3 independent cohorts. Gastroenterology, 158:270-272. https://doi.org/10.1053/j.gastro.2019.024            Duan, J., et al. (2021). The mechanisms of wine phenolic compounds for preclinical anticancer therapies. Food and Nutrition Research, 65:6507. http://dx.doi.org/10.29219/fnr:v65.6507            Zhao, L., et al. (2023). Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Liver Cancer and Chronic Liver Disease Mortality. JAMA, 330(6), 537–546. https://doi.org/10.1001/jama.2023.12618            Debras, C., et al. (2022). Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. PLoS medicine, 19(3), e1003950. https://doi.org/10.1371/journal.pmed.1003950            Zhang, J., et al. (2019). Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study. Gut.BMJ; 68:1971-1978. doi: 10.1136/gutnl-2019-318593

En lo último en salud y fitness edición de octubre 2024, damos un paseo por las últimas tendencias, investigaciones y noticias en el mundo de la salud y el fitness. Desde la ciencia detrás de ajustar la intensidad del ejercicio para mejorar la adherencia a los programas de entrenamiento, hasta los impactos de pasar mucho tiempo sentado y cómo la actividad física puede marcar la diferencia. También hablaremos sobre los beneficios de la creatina en combinación con el entrenamiento de resistencia y cómo ciertas frutas y verduras pueden ser tus mejores aliadas en la prevención de enfermedades crónicas. Atajos del Episodio 01:09 - Efecto del Autoajuste de Intensidad en el Ejercicio Según el Placer en la Asistencia a Sesiones de Ejercicio1 03:52 - ¿Cuál es la manera más efectiva de calentar antes de entrenar fuerza?2 06:07 - Pasar mucho tiempo sentado es dañino para la salud de personas sedentarias y no para las que tienen actividad física más regular3 10:24 - Un estudio más sobre la efectividad de la creatina4 13:35 - El impacto de las frutas y verduras en la prevención de enfermedades crónicas5   Referencias:  1.      Teixeira, D. S., Bastos, V., Andrade, A. J. & Palmeira…, A. L. Individualized pleasure-oriented exercise sessions, exercise frequency, and affective outcomes: a pragmatic randomized controlled trial. International Journal of … (2024). 2.      Souza, D., Silva, A. G., Vale, A., Pessoni, A. & Galvão…, L. Effect of warm-up protocols using lower and higher loads on multiple-set back squat volume-load. PeerJ (2024). 3.      Dai, W. & Albrecht, S. S. Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in US Adults With Diabetes. Diabetes Care (2024). 4.      Desai, I., Wewege, M. A. & Jones…, M. D. The Effect of Creatine Supplementation on Resistance Training–Based Changes to Body Composition: A Systematic Review and Meta-analysis. The Journal of … (2022). 5.      Zhang, Y., Tabung, F. K. & Smith-Warner…, S. A. High-quality fruit and vegetable characterized by cardiometabolic biomarkers and its relation to major chronic disease risk: results from three prospective US cohort …. The American Journal of … (2024).

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.  This issue will review: 1.     Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction 2.     Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure 3.     Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10) 4.     Diabetes, prediabetes, and brain aging: the role of healthy lifestyle 5.     Sitting Time and Its Interaction with Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes   For more information about each of ADA's science and medical journals, please visit www.diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

Try TrainerRoad risk-free!

Exercise is a key player in building a SuperLife and increasing longevity - it's extremely hard to live your happiest and healthiest life without a strong, functional body. That's why, in this episode of SuperLife, I'm going to give you an exercise protocol you can easily follow to increase your longevity.    I discuss the importance of cardiovascular health and muscle strength, exploring activities from walking and running to swimming, cycling, and even jumping rope. I also discuss the often-overlooked benefits of flexibility and balance, how to craft a well-rounded strength training regimen that targets all major muscle groups, and why we should all focus on Zone 2 cardio.    Don't forget… You can order now by heading to https://darinolien.com/fatal-conveniences-book or order now on Amazon.   Thank you to our sponsors: Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Barùkas: Go to www.barukas.com and use code DARINPOD10 for a 10% discount   Find more from Darin: Website: https://darinolien.com/ Instagram: https://www.instagram.com/Darinolien/ Book: https://darinolien.com/fatal-conveniences-book/ Down to Earth: https://darinolien.com/down-to-earth/      Resources:  Resistance Training Program Design: Westcott, W. L. Association Between Running, All-Cause and Cardiovascular Mortality: Lee, D. C., Pate, R. R., Lavie, C. J., Sui, X., Church, T. S., Blair, S. N. Yoga for Chronic Disease: Yoga Improves Quality of Life, Health, and Well-being: Cramer, H., Lauche, R., Langhorst, J., Dobos, G. Association Between Muscle-Strengthening Activities and Mortality Risk: Kraschnewski, J. L., Sciamanna, C. N., Ciccolo, J. T., Rovniak, L. S., Lehman, E. B., Ballentine, N. H., Desantis, J., Barber, C. A.

Between 2019 and 2021, pediatric mortality rates had the largest increases in at least half a century. Steven H. Woolf, MD, MPH, of Virginia Commonwealth University Center on Society and Health, joins JAMA Associate Editor Tracy A. Lieu, MD, MPH, to discuss how racial and ethnic disparities and specific causes have factored into these increases and what this means for policymakers and clinicians. Related Content: Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US Youth Injury Prevention Science and Firearm Injury in Pediatric Health

In this episode. we'll dive into an issue that's been causing quite a bit of unnecessary worry among us, especially as breast cancer survivors. We're constantly bombarded with alarming headlines claiming that another everyday habit or food is suddenly a health hazard. I'm here to break down those fears and offer some clarity. While it's crucial to stay informed, it's equally important to approach these headlines with a healthy dose of skepticism. I share my own frustration over how some studies are often exaggerated by the media, creating fear around lifestyle practices that are, more often than not, perfectly healthy. I delve into how to recognize these misleading headlines and the importance of looking beyond them. I stress the need to consider the actual data behind these studies – which, as it turns out, often isn't as conclusive as it's presented. I encourage my breast cancer community not to let these fear-mongering tactics detract from our health and wellness journey. Together, we can navigate through the sea of information with wisdom and grace, keeping our focus on thriving, not just surviving.   Referred to in this episode: Metabolic Health Coaching 5 brilliant graphs that teach correlation vs. causality Intermittent fasting linked to 91% increase in risk of death from heart disease, study says The intermittent fasting trend may pose risks to your heart Association of 8-Hour Time-Restricted Eating with All-Cause and Cause-Specific Mortality Data Books: The Obesity Code Fast Like a Girl Delay Don't Deny Follow me on Social Media:  Facebook Instagram Pinterest YouTube

V tomto podcaste budeme hovoriť o štúdii, ktorá sa pozerala na vplyv prerušovaného pôstu na kardiovaskulárne ochorenia, ako optimálne tepelne upravovať brokolicu a na fluór v doplnkoch výživy. Zdroje Association Between Time-Restricted Eating and All-Cause and Cause-Specific Mortality 8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death Scientists Reveal a Healthier Way to Cook Broccoli – But There's a Catch Fluoride in Drinking Water: A Scientific Review of EPA's Standards Fluoride Image by Andrea from Pixabay

In this 217th in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we talk about the state of the world through an evolutionary lens.In this episode, we discuss the Supreme Court, the First Amendment, Covid, censorship, DEI, the Rawlsian Veil of Ignorance, and affirmative action, in the context of Murthy v State of Missouri. We also talk about Goliath being a combination of emergence and collusion, and how facts are being used to support existing narratives, rather than stories being constructed using all of the facts. We discuss two explosive pieces of research that dropped this week—on the health risks of heat, and of intermittent fasting. And we briefly talk about why you should never cave to the mob (beaver edition).*****Our sponsors:Momentous: high-quality, science-backed, rigorously tested supplements. Go to livemomentous.com and use code DARKHORSE for 15% off.Moink: Grass-fed and grass-finished beef and lamb, pastured pork and chicken, and wild caught Alaskan salmon. Visit www.moinkbox.com/darkhorse to get a year's worth of hamburger free when you sign up. Seed: Start a new healthy habit today with Seed probiotics. Use code darkhorse at https://seed.com/darkhorse to get 25% off your first month of Seed's DS-01® Daily Synbiotic.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.com/Heather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://a.co/d/dunx3atCheck out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:Case File 23-411: Murthy v State of Missouri: https://www.supremecourt.gov/DocketPDF/23/23-411/299644/20240202144405984_2024-02-02%20-%20Murthy%20v.%20Missouri%20-%20Brief%20of%20Respondents%20-%20Final%20with%20Tables.pdfHypothesis about Goliath: https://twitter.com/alexandrosm/status/1770219558990938294Sunbathing for just ONE DAY is super bad for you (except it's not): https://www.dailymail.co.uk/wellness-us/body/article-13215737/sunbathing-heart-disease-risk-skin-cancer.htmlResearch Abstract: Associations Between Short-Term Outdoor Heat Measures and Markers of Immune Response and Inflammation: https://www.abstractsonline.com/pp8/#!/20343/presentation/484Research Abstract: Association Between Time-Restricted Eating and All-Cause and Cause-Specific Mortality: https://www.abstractsonline.com/pp8/#!/20343/presentation/379Never Cave to the Mob: https://naturalselections.substack.com/p/never-cave-to-the-mobSupport the show

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications:1. Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US AdultsGuest:Philip Lieberman, MD, Resident – Family Medicine Residency Program Jefferson Health – Abington 2. Association between changes in carbohydrate intake and long term weight changes: prospective cohort studyWalter C. Willett, M.D., Dr. P.H.Professor of Epidemiology and Nutrition at Harvard T.H. Chan School of Public Health, Professor of Medicine, Harvard Medical School3. Clinically Important Benefits and Harms of Monoclonal Antibodies Targeting Amyloid for the Treatment of Alzheimer Disease: A Systematic Review and Meta-AnalysisRichard Potter, MD, Resident – Family Medicine Residency Program Jefferson Health – AbingtonMedical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Let's delve into the latest walking research and trends, to find out if we need to tweak our routines! What does 4,000 steps a day get us? Can walking help us fight chronic conditions, such as high blood pressure and dementia? What does our walking ability say about our health? Then, we'll decide if we want to try retro walking or the popular 12-3-30 treadmill workouts! We'll also touch on how to simplify health goals to reduce overwhelm and increase results! LET'S TALK THE WALK! ***NEW*** Facebook Group for Our Community! Join here for support, motivation and fun! Wellness While Walking Facebook page Wellness While Walking on Instagram Wellness While Walking on Twitter Wellness While Walking website for show notes and other information wellnesswhilewalking@gmail.com Wellness While Walking on Threads   RESOURCES AND SOURCES (some links may be affiliate links) THE BENEFITS OF 3000 AND 4000 STEPS + RETRO WALKING + THE 12-3-30 TIKTOK REGIMEN + MORE! Wellness While Walking Episode 147. Walking for Fitness, Health, Weight Loss and More: What Does the Research Say, with Prof. Marie Murphy Patient Self-Assessment of Walking Ability and Fracture Risk in Older Australian Adults, jamanetwork.com Walking Fitness Can Predict Fracture Risk in Older Adults, worldhealth.net Your Walking Speed Reveals More About Your Health Than You Realize, goodmenproject.com Increasing Lifestyle Walking by 3000 Steps per Day Reduces Blood Pressure in Sedentary Older Adults with Hypertension, mdpi.com Walking for Seniors: Experts Share the Benefits and How to Get Started, care.com The Significant Health Benefits of Walking Backwards, cnn.com Backwards Walking, nordicwalkingeastanglia.co.uk Can TikTok's Walking Backward Trend Really Help You Improve Fitness and Lose Weight? healthline.com Walking Backward Has An Unexpected Effect On Your Health, healthdigest.com Ask Health: Is 12-3-30 Really a Good Workout? health.com What Experts Think of the 12-3-30 TikTok Treadmill Workout, healthline.com Why Walking Just 4,000 Steps a Day is All Your Brain Needs, Science Says, bestlifeonline.com The Association Between Daily Step Count and All-Cause and Cardiovascular Mortality, academic.oup.com Stay Active, Boost Brain Health: Exercise Linked to Larger Brain, neurosciencenews.com Stop the Clocks: Brisk Walking May Slow Biological Aging Process, Study Shows, sciencedaily.com     HOW TO RATE AND REVIEW WELLNESS WHILE WALKING How to Leave a Review on Apple Podcasts on Your iOS Device 1.   Open Apple Podcast App (purple app icon that says Podcasts). 2.   Go to the icons at the bottom of the screen and choose “search” 3.   Search for “Wellness While Walking” 4.   Click on the SHOW, not the episode. 5.   Scroll all the way down to “Ratings and Reviews” section 6.   Click on “Write a Review” (if you don't see that option, click on “See All” first) 7.   Then you will be able to rate the show on a five-star scale (5 is highest rating) and write a review! 8.   Thank you! I so appreciate this!   How to Leave a Review on Apple Podcasts on a Computer  1.   Visit Wellness While Walking page on Apple Podcasts in your web browser (search for Apple Podcasts or click here)  https://www.apple.com/apple-podcasts/ 2.   Click on “Listen on Apple Podcasts” or “Open the App” 3.   This will open Apple Podcasts and put in search bar at top left “Wellness While Walking” 4.   This should bring you to the show, not a particular episode – click on the show's artwork 5.   Scroll down until you see “Rating and Reviews” 6.   Click on “See All” all the way to the right, near the Ratings and Review Section and its bar chart 7.   To leave a written review, please click on “Write a Review” 8.   You'll be able to leave a review, along with a title for it, plus you'll be able to rate the show on the 5-star scale (with 5 being the highest rating) 9.   Thank you so very much!! OTHER APPS WHERE REVIEWS ARE POSSIBLE Spotify Castbox Podcast Addict Podchaser Podbean Overcast (if you star certain episodes, or every one, that will help others find the show)  Goodpods   HOW TO SHARE WELLNESS WHILE WALKING Tell a friend or family member about Wellness While Walking, maybe while you're walking together or lamenting not feeling 100% Follow up with a quick text with more info, as noted below! (My favorite is pod.link/walking because it works with all the apps!) Screenshot a favorite episode playing on your phone and share to social media or to a friend via text or email! Wellness While Walking on Apple – click the up arrow to share with a friend via text or email, or share to social media Wellness While Walking on Spotify -- click the up arrow to share with a friend via text or email, or share to social media Use this universal link for any podcast app: pod.link/walking – give it to friends or share on social media Tell your pal about the Wellness While Walking website Thanks for listening and now for sharing! : )       DISCLAIMER Neither I nor many of my podcast guests are doctors or healthcare professionals of any kind, and nothing on this podcast or associated content should be considered medical advice. The information provided by Wellness While Walking Podcast and associated material, by Whole Life Workshop and by Bermuda Road Wellness LLC is for informational and entertainment purposes only. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment, and before undertaking a new health care regimen, including walking.     Thanks for listening to Wellness While Walking, a walking podcast and a "best podcast for walking"!        

Why are syphilis cases on the rise? In this episode: what doctors need to know about syphilis transmission, how to treat syphilis, plus congenital syphilis. AMA's Vice President of Science, Medicine and Public Health, Andrea Garcia, JD, MPH, also shares the latest cancer statistics, why cancer cases are on the rise and tips to reduce the harmful effects of sitting. American Medical Association CXO Todd Unger hosts.

Schwere Mangelerscheinungen, erhöhtes Krebsrisiko und Depressionen: die Folge eines Vitamin D Mangels? Ob du im Winter Vitamin D supplementieren solltest und was es hier unbedingt zu beachten gibt, erfährst du in dieser Podcast Folge! Hier geht es zur Ernährungsberater Lizenz der KAF Akademie: https://kaf-akademie.de/produkt/ernaehrungsberater-lizenz/ Hier geht es zu Tim's neuem Buch "Dein Weg zum Personal Trainer": https://wegzumpersonaltrainer.de/ (Du übernimmst nur die Versand- und Logistikpauschale) Quellen: Ginde, A. A., Blatchford, P. J., Breese, K., Zarrabi, L., Linnebur, S. A., Wallace, J. I. & Schwartz, R. S. (2016). High-Dose monthly vitamin D for prevention of acute respiratory infection in older Long-Term Care residents: a randomized clinical trial. Journal of the American Geriatrics Society, 65(3), 496–503. https://doi.org/10.1111/jgs.14679 Garland, C. F., Gorham, E. D., Mohr, S. B., Grant, W. B., Giovannucci, E., Lipkin, M., Newmark, H. L., Holick, M. F. & Garland, F. C. (2007). Vitamin D and Prevention of breast Cancer: pooled analysis. The Journal of Steroid Biochemistry and Molecular Biology, 103(3–5), 708–711. https://doi.org/10.1016/j.jsbmb.2006.12.007 Harris, S. S., Pittas, A. G. & Palermo, N. J. (2012). A randomized, placebo‐controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes, Obesity and Metabolism, 14(9), 789–794. https://doi.org/10.1111/j.1463-1326.2012.01605.x The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in Type 2 diabetic patients. (2003). PubMed. https://pubmed.ncbi.nlm.nih.gov/12800453/ Dobnig, H. (2008). Independent association of low serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D levels with All-Cause and cardiovascular mortality. Archives of internal medicine, 168(12), 1340. https://doi.org/10.1001/archinte.168.12.1340 Biesalski, H. K., Grimm, P. & Nowitzki-Grimm, S. (2020). Taschenatlas Ernährung (8., vollständig überarbeitete Aufl.). Thieme. Rittenau, N. (2020). Vegan Klischee Ade! Wissenschaftliche Antworten auf kritische Fragen zu pflanzlicher Ernährung. Becker Joest Volk Verlag. Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung & Schweizerische Gesellschaft für Ernährung (Hrsg.). (2021). Referenzwerte für die Nährstoffzufuhr (2. Auflage, 7. aktualisierte Ausgabe). DGE.

Tania Elfersy is a transformative coach, speaker and award-winning author, specializing in midlife women's health. Tania has spent years researching what causes and what can relieve symptoms associated with perimenopause and menopause. She became free of her own physical and emotional symptoms naturally and simply, through insight alone.The Wiser WomanTania Elfersy (@4TheWiserWoman) / TwitterTania Elfersy | FacebookThe Wiser Woman CourseIf you are in a crisis or think you have an emergency, call your doctor or 911. If you're considering suicide, call 1-800-273-TALK to speak with a skilled trained counselor.RADICALLY GENUINE PODCASTRadically Genuine Podcast Website Twitter: Roger K. McFillin, Psy.D., ABPPInstagram @radgenpodTikTok @radgenpodRadGenPodcast@gmail.comADDITIONAL RESOURCES15:00 - What is Divine Intelligence? | by Dr. Jayne Gardner | Medium21:00 - Why Killer Whales (and Humans) Go Through Menopause - The Atlantic35:00 - Feminine Forever: Wilson, Robert A35:30 - ESTROGEN THERAPY—A WARNING | JAMA36:00 - Editorial: Cancer risk and estrogen use in the menopause36:30 - Estrogen Is Linked To Uterine Cancer - The New York Times37:30 - Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial38:30 - (2017) Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials39:00 - The 2017 hormone therapy position statement of The North American Menopause Society40:00 - Osteoporosis, bone health, menopause, HRT and the confusing messages of medicine41:00 - 2013 Global Consensus Statement on Menopausal Hormone Therapy43:00 - Association between menopausal hormone therapy and risk of neurodegenerative diseases: Implications for precision hormone therapy49:00 - "Sitting the Month": a new mom's experience in self-care and motherhood – Cold Tea Collective49:30 - Menopause Around the World

Does weight loss surgery make you thin? What percentage of people is it successful for? Are the side effects worth it and what are they exactly? This episode is a deep dive into bariatric surgery AKA "weight loss" surgery AKA stomach amputation. CW: There are mentions of the O Words, suicide rates and brief mention of calories. Episode show notes: http://www.fiercefatty.com/165 Support me on Ko-Fi and get the Size Diversity Resource Guide: https://ko-fi.com/fiercefatty/tiers Comparison of the Performance of Common Measures of Weight Regain After Bariatric Surgery for Association With Clinical Outcomes: https://jamanetwork.com/journals/jama/fullarticle/2707460 All-Cause and Cause-Specific Mortality Associated with Bariatric Surgery: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055056/#:~:text=findings%20have%20emerged.-,Bariatric%20surgical%20patients%20have%3A%201 Comparison of the Performance of Common Measures of Weight Regain After Bariatric Surgery for Association With Clinical Outcomes: https://jamanetwork.com/journals/jama/fullarticle/2707460 Body Image Disturbances and Weight Bias After Obesity Surgery: Semantic and Visual Evaluation in a Controlled Study, Findings from the BodyTalk Project: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012323/  Coping With "ob*sity" Stigma Affects Depressed Mood in African-American and White Candidates for Bariatric Surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670735/#R4 Death Rates and Causes of Death After Bariatric Surgery for Pennsylvania Residents, 1995 to 2004: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888907/ Depression, Anxiety, and Binge Eating Before and After Bariatric Surgery: Problems that Remain: https://www.scielo.br/j/abcd/a/tZXDCfc855KxdXcFKTbVtHR/?lang=en Diabetes after Bariatric Surgery: https://www.canadianjournalofdiabetes.com/article/S1499-2671(16)30072-7/fulltext Ethical questions about surgery raised by scientists: https://jamanetwork.com/journals/jama/article-abstract/196339 Late Relapse of Diabetes After Bariatric Surgery: Not Rare, but Not a Failure: https://diabetesjournals.org/care/article/43/3/534/35625/Late-Relapse-of-Diabetes-After-Bariatric-Surgery Long-Term Follow-up After Bariatric Surgery: A Systematic Review: https://jamanetwork.com/journals/jama/fullarticle/1900516 Long-Term Outcomes After Bariatric Surgery: a Systematic Review and Meta-analysis of Weight Loss at 10 or More Years for All Bariatric Procedures and a Single-Centre Review of 20-Year Outcomes After Adjustable Gastric Banding: https://link.springer.com/article/10.1007/s11695-018-3525-0 Mineral Malnutrition Following Bariatric Surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771134/#:~:text=Bariatric%20surgery%20exacerbates%20preexisting%20malnutrition,with%20micronutrient%20supplementation%20following%20surgery. Patient experiences of outcomes of bariatric surgery: a systematic review and qualitative synthesis: https://onlinelibrary.wiley.com/doi/10.1111/obr.12518 Prevalence of alcohol use disorders before and after bariatric surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682834/#:~:text=There%20is%20some%20evidence%20that Recent Experiences of Weight-based Stigmatization in a Weight Loss Surgery Population: Psychological and Behavioral Correlates: https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2008.457 Risk of suicide and non-fatal self-harm after bariatric surgery: results from two matched cohort studies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932484/ Risk of suicide and self-harm is increased after bariatric surgery - a systematic review and meta-analysis: https://link.springer.com/article/10.1007/s11695-018-3493-4 Substance Use after Bariatric Surgery: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789154/ Suicide rates after bariatric surgery: https://bariatrictimes.com/understanding-postoperative-suicide-self-injury/#:~:text=Based%20on%20their%20analysis%2C%20the,3.2%E2%80%935.1%2F10%2C000 Survival among high-risk patients after bariatric surgery: https://pubmed.ncbi.nlm.nih.gov/21666276/#:~:text=Results%3A%20Among%20patients%20who%20had,and%2015.2%25%20for%20nonsurgical%20controls. The Impact of Bariatric Surgery on Psychological Health: https://www.hindawi.com/journals/jobe/2013/837989/ Untold stories of living with a bariatric body: long-term experiences of weight-loss surgery: https://onlinelibrary.wiley.com/doi/10.1111/1467-9566.12999 “But Everything Is Supposed to Get Better After Surgery!” Understanding Postoperative Suicide and Self-Injury: https://bariatrictimes.com/understanding-postoperative-suicide-self-injury/ Long-term weight regain after gastric bypass: a 5-year prospective study: https://www.researchgate.net/publication/5459557_Long-term_Weight_Regain_after_Gastric_Bypass_A_5-year_Prospective_Study Anti-Diet by Christy Harrison: https://christyharrison.com/book-anti-diet-intuitive-eating-christy-harrison Ethical Questions About Surgery Raised By Scientists: https://jamanetwork.com/journals/jama/article-abstract/196339 Food Junk Science Blog: http://junkfoodscience.blogspot.com/2007/01/junkfood-science-weekend-special.html Suicide Rates: https://bariatrictimes.com/understanding-postoperative-suicide-self-injury/#:~:text=Based%20on%20their%20analysis%2C%20the,3.2%E2%80%935.1%2F10%2C000  Kaitlin Anderle Who Had Surgery: https://www.instagram.com/p/B9B7HwSh3RM/ Roxane Gay - What Fullness Is: https://gay.medium.com/the-body-that-understands-what-fullness-is-f2e40c40cd75 Lindo Bacon on Bariatric Surgery: https://www.lindobacon.com/HAESbook/pdf_files/HAES_Bariatric-Surgery.pdf Prevalence of alcohol use disorders before and after bariatric surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682834/#:~:text=There%20is%20some%20evidence%20that Mineral Malnutrition Following Bariatric Surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771134/#:~:text=Bariatric%20surgery%20exacerbates%20preexisting%20malnutrition,with%20micronutrient%20supplementation%20following%20surgery. Substance Use after Bariatric Surgery: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789154/ Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures: https://pubmed.ncbi.nlm.nih.gov/16234496/#:~:text=The%20rates%20of%2030%2Dday,001 All-Cause and Cause-Specific Mortality Associated with Bariatric Surgery: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055056/#:~:text=findings%20have%20emerged.-,Bariatric%20surgical%20patients%20have%3A%201 Survival among high-risk patients after bariatric surgery: https://pubmed.ncbi.nlm.nih.gov/21666276/#:~:text=Results%3A%20Among%20patients%20who%20had,and%2015.2%25%20for%20nonsurgical%20controls. Death Rates and Causes of Death After Bariatric Surgery for Pennsylvania Residents, 1995 to 2004: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888907/ No evidence that bariatric surgeries save healthcare costs or save lives: http://junkfoodscience.blogspot.com/2008/09/no-evidence-that-bariatric-surgeries.html Quote from Junkfood Science: http://junkfoodscience.blogspot.com/2007/02/rumor-versus-facts.html Accidents or Unintentional Injuries: https://www.cdc.gov/nchs/fastats/accidental-injury.htm Early Mortality Among Medicare Beneficiaries Undergoing Bariatric Surgical Procedures: https://jamanetwork.com/journals/jama/fullarticle/201707

Are you aware that your daily eating habits have a significant impact on your mortality risk? In this video, we will explore the latest research findings on the association between meal skipping, shorter meal intervals, and increased risk of all-cause and cardiovascular disease mortality among US adults.Reference: Sun, Yangbo et al. Meal Skipping and Shorter Meal Intervals Are Associated with Increased Risk of All-Cause and Cardiovascular Disease Mortality among US Adults. Journal of the Academy of Nutrition and Dietetics, Volume 123, Issue 3, 417 - 426.e3VISIT OUR STOREStore: https://www.selfelements.comFOLLOW USwww.selfprinciple.orgwww. youtube.com/selfprinciplewww.youtube.com/plantbasedkidneyhealthwww.instagram.com/seanhashmimd

We read new nutrition studies all the time. And we love it! But we recently realized that we never share the most exciting ones with you. So in today's episode we're covering 4 newly published studies that caught our attention—and we think they'll catch yours. Will taking a probiotic shrink your waist? Is exercise just as important for your mental health as counseling? Can chocolate and water help you live longer? Let's dive in.  References and links mentioned in the episode:  The Effect of Microbiome Therapies on Waist Circumference, a Measure of Central Obesity, in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials   Chocolate Consumption in Relation to All-Cause and Cause-Specific Mortality in Women: The Women's Health Initiative   Exercise more effective than medicines to manage mental health   Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality   Does Dehydration Cause High Blood Pressure?   Show Notes:  Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions

We read new nutrition studies all the time. And we love it! But we recently realized that we never share the most exciting ones with you. So in today's episode we're covering 4 newly published studies that caught our attention—and we think they'll catch yours. Will taking a probiotic shrink your waist? Is exercise just as important for your mental health as counseling? Can chocolate and water help you live longer? Let's dive in.  References and links mentioned in the episode:  The Effect of Microbiome Therapies on Waist Circumference, a Measure of Central Obesity, in Patients with Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials   Chocolate Consumption in Relation to All-Cause and Cause-Specific Mortality in Women: The Women's Health Initiative   Exercise more effective than medicines to manage mental health   Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality   Does Dehydration Cause High Blood Pressure?   Show Notes:  Thank you for listening to The Happy Eating Podcast. Tune in weekly on Thursdays for new episodes! For even more Happy Eating, head to our website!  https://www.happyeatingpodcast.com Learn More About Our Hosts:  Carolyn Williams PhD, RD: Instagram: https://www.instagram.com/realfoodreallife_rd/ Website: https://www.carolynwilliamsrd.com Facebook: https://www.facebook.com/RealFoodRealLifeRD/ Brierley Horton, MS, RD Instagram: https://www.instagram.com/brierleyhorton/ Got a question or comment for the pod? Please shoot us a message!  happyeatingpodcast@gmail.com Produced by Lester Nuby OE Productions

On this week's podcast, Drs. Baraki and Feigenbaum discuss the extreme exercise hypothesis. Sponsors: https://generalleathercraft.com/ www.bellsofsteel.us Use code "BBM23" for 10% off select items https://vuoriclothing.com/pages/pod_bbm_sp23 (get 20% off your first order) Got Pain? Contact Us: https://www.barbellmedicine.com/contact-us-coaching-inquiry/ References: The “Extreme Exercise Hypothesis”: Recent Findings and Cardiovascular Health Implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132728/ Effect of Sex and Sporting Discipline on LV Adaptation to Exercise https://pubmed.ncbi.nlm.nih.gov/27865722/ Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athlete's heart https://pubmed.ncbi.nlm.nih.gov/23474689/ The athlete's heart: a contemporary appraisal of the 'Morganroth hypothesis' https://pubmed.ncbi.nlm.nih.gov/18081368/ A comparison of cardiac structure and function between female powerlifters, fitness-oriented athletes, and sedentary controls https://pubmed.ncbi.nlm.nih.gov/32892422/ Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the ASPC Part I: Bioenergetics, contemporary physical activity recommendations, benefits, risks, extreme exercise regimens, potential maladaptations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586848/ Dose-response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands https://pubmed.ncbi.nlm.nih.gov/34855764/ Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification https://jamanetwork.com/journals/jamacardiology/fullarticle/2722746 A prospective randomised longitudinal MRI study of left ventricular adaptation to endurance and resistance exercise training in humans https://pubmed.ncbi.nlm.nih.gov/21969450/ Anabolic Androgenic Steroids Induce Reversible Left Ventricular Hypertrophy and Cardiac Dysfunction. Echocardiography Results of the HAARLEM Study https://pubmed.ncbi.nlm.nih.gov/36304014/ Myocardial Fibrosis in Athletes https://pubmed.ncbi.nlm.nih.gov/27720455/ For more of our stuff: App: https://tinyurl.com/muus5pfn Podcasts: goo.gl/X4H4z8 Website: www.barbellmedicine.com Instagram: @austin_barbellmedicine @jordan_barbellmedicine @leah_barbellmedicine @vanessa_barbellmedicine @untamedstrength @derek_barbellmedicine @hassan_barbellmedicine @charlie_barbellmedicine @alex_barbellmedicine @tomcampitelli @joe_barbellmedicine @rheece_barbellmedicine @cam_barbellmedicine @claire_barbellmedicine @ben_barbellmedicine @cassi.niemann @caleb_barbellmedicine Email: info@barbellmedicine.com Supplements/Templates/Seminars: www.barbellmedicine.com/shop/ Forum: forum.barbellmedicine.com/

Sjefredaktør Are Brean starter 2023 med et tilbakeblikk på de mest leste og mest delte artiklene i vårt eget og flere internasjonale medisinske tidsskrifter gjennom 2022. Ikke overraskende var artikler om covid-19 godt representert i toppen, sammen med artikler om overvekt og matvaner. I tillegg trekkes blant annet artikler om skytevåpen i USA frem, og en artikkel om søvnvaner og dødelighet. Flere av artiklene på de internasjonale topplistene kommer dessuten fra norske forskermiljøer.Tilbakemeldinger kan sendes til stetoskopet@tidsskriftet.no. Stetoskopet produseres av Synne Muggerud Sørensen, Sigurd Ziegler, Are Brean og Julie Didriksen ved Tidsskrift for Den norske legeforening. Ansvarlig redaktør er Are Brean. Jingle og lydteknikk: Håkon Braaten / Moderne media Coverillustrasjon: Stephen Lee Artikler nevnt: Tidsskriftets mest leste saker i 2022Vektreduserende medisiner – for hvem, hvordan, hvor lenge?Effekt av tre doser koronavaksine Estimating impact of food choices on life expectancy: A modeling study Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021 The Growing Influence of State Governments on Population Health in the United StatesNature's 10Global health nonsense Best of Annals 2022 Articles Firearm Purchasing During the COVID-19 Pandemic: Results From the 2021 National Firearms Survey Homicide Deaths Among Adult Cohabitants of Handgun Owners in California, 2004 to 2016: A Cohort Study Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality: A Large Prospective Cohort Study Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank: A Prospective Cohort StudyAssociation of sleep duration at age 50, 60, and 70 years with risk of multimorbidity in the UK: 25-year follow-up of the Whitehall II cohort study

Qui dit fin d'année dit remise de prix au Gala des grands crus et des piquettes du Pharmascope! Ne manquez pas cette 6ème édition du Gala dans lequel Nicolas, Sébastien et Isabelle dévoilent les gagnants de célèbres catégories comme Meilleur nom d'étude, Étude la plus disciplinée ou encore la catégorie Alimentaire. ** Veuillez noter que cet épisode ne rencontre pas les critères d'admissibilité pour l'octroi d'unités de formation continue ou de crédits Mainpro+ Ressources pertinentes en lien avec l'épisode La catégorie “meilleur nom d'étude”Tapper EB et coll. Pickle Juice Intervention for Cirrhotic Cramps Reduction: The PICCLES Randomized Controlled Trial. Am J Gastroenterol. 2022;117:895-901. La catégorie “alimentaire”Inoue-Choi M et coll. Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank : A Prospective Cohort Study. Ann Intern Med. 2022;175:1201-11. Jones C, Francis J. Direct Uptake of Nutrition and Caffeine Study (DUNCS): biscuit based comparative study. BMJ. 2022;379:e072839. Koyama T et coll. Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial. Am J Gastroenterol. 2022;117:1714-17. La catégorie “gastro-intestinale”Doğan İG et coll. Abdominal Massage in Functional Chronic Constipation: A Randomized Placebo-Controlled Trial. Phys Ther. 2022;102:pzac058. La catégorie “auto-prélèvement”Aasbø G et coll. HPV self-sampling among long-term non-attenders to cervical cancer screening in Norway: a pragmatic randomised controlled trial. Br J Cancer. 2022;127:1816-26. La catégorie “étude la plus disciplinée”Liu D et coll. Calorie Restriction with or without Time-Restricted Eating in Weight Loss. N Engl J Med. 2022;386:1495-504. La catégorie “orthographe”Weiand D, Lumb J. Misspelling of antimicrobials by healthcare professionals. BMJ. 2022;379:o2946.

Nå foreligger det mer forskning på de første smitteutbruddene av SARS-CoV-2, der man blant annet har kunnet påvise at tidlige zoonotiske varianter av viruset må ha eksistert på våtmarkeder i Wuhan i flere år før pandemiens utbrudd. En annen nylig publisert studie har sett på forekomsten av sekveler etter SARS-CoV-2-infeksjon hos barn. Kan man stole på resultatet av neseprøver som barn tar selv? Og beskytter briller mot smitte?Den hittil største kohortstudien av apekoppertilfeller er nettopp publisert, og der finnes mye nyttig informasjon for de som jobber klinisk med denne pasientgruppen.Antitrombotisk behandling etter gjennomgått hjerteinfarkt handler om å balansere risikoen for ny trombose på den ene siden og risikoen for blødning på den andre. Men er en av disse farligere enn den andre?I tillegg får du blant annet høre mer om abortsituasjonen i USA og i Sør-Amerika, om den globale kreftbyrden og tilknyttede risikofaktorer, og sammenhengen mellom tedrikking og dødelighet.Tilbakemeldinger kan sendes til stetoskopet@tidsskriftet.no. Stetoskopet produseres av Caroline Ulvin Johansson, Are Brean og Julie Didriksen ved Tidsskrift for Den norske legeforening. Ansvarlig redaktør er Are Brean. Jingle og lydteknikk: Håkon Braaten / Moderne media Coverillustrasjon: Stephen LeeArtikler nevnt:The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemicThe molecular epidemiology of multiple zoonotic origins of SARS-CoV-2Wildlife trade is likely the source of SARS-CoV-2Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and AdolescentsConcordance of SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents Covid-19: Study provides further evidence that mRNA vaccines are safe in pregnancy Safety of COVID-19 vaccines in pregnancy: a Canadian National Vaccine Safety (CANVAS) network cohort studyAssociation of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022Monkeypox — Past as Prologue ‘He has saved countless lives': US scientists on Fauci leaving NIH role Association of Ischemic and Bleeding Events With Mortality Among Patients in Sweden With Recent Acute Myocardial Infarction Receiving Antithrombotic Therapy | Acute Coronary Syndromes The best response to US criminalisation of abortion is decriminalisation elsewhere After Roe v Wade: US doctors are harassed, confused, and fearful, and maternal morbidity is increasing The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019Association Between Changes in Alcohol Consumption and Cancer RiskTea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank

In this bite-sized special bonus episode, we're exploring what the science says about the impact of eating eggs on our health.    Episode sources: Mousavi SM, Zargarzadeh N, Rigi S, Persad E, Pizarro AB, Hasani-Ranjbar S, Larijani B, Willett WC, Esmaillzadeh A. Egg Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2022 Apr 9:nmac040. doi: 10.1093/advances/nmac040. Epub ahead of print. PMID: 35396834. Zhao B, Gan L, Graubard BI, Männistö S, Albanes D, Huang J. Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality, and Systematic Review and Updated Meta-Analysis. Circulation. 2022 Apr 1. doi: 10.1161/CIRCULATIONAHA.121.057642. Epub ahead of print. PMID: 35360933. Yang PF, Wang CR, Hao FB, Peng Y, Wu JJ, Sun WP, Hu JJ, Zhong GC. Egg consumption and risks of all-cause and cause-specific mortality: a dose-response meta-analysis of prospective cohort studies. Nutr Rev. 2022 Feb 18:nuac002. doi: 10.1093/nutrit/nuac002. Epub ahead of print. PMID: 35178575.

Do you remember what was happening in 2021? That's right there was a massive "vaccine" campaign under the direction of our "wise" leaders in the National Government. Now we know there was a HUGE increase in ALL CAUSE in 2021. This comes from one of the most reliable sources on the planet, Life Insurance Companies. Join me today as we dig into this and lay the blame squarely where it belongs! --- Send in a voice message: https://podcasters.spotify.com/pod/show/seth-martin0/message

Wszechobecny cukier dodawany jest do żywności i napojów w ogromnych ilościach, czy na przestrzeni lat stają się one coraz słodsze? Czy można ustalić poglądy polityczne opierając się tylko na skanie mózgu? Jaką skuteczność mają grafolodzy dokonujący analiz kryminalistycznych? W 41. odcinku podkastu usłyszycie również o papierowych bateriach, sprawdzimy także ile czasu powinna wynosić optymalna aktywność fizyczna.Jeśli uznasz, że warto wspierać ten projekt to zapraszam do serwisu Patronite, każda dobrowolna wpłata od słuchaczy pozwoli mi na rozwój i doskonalenie tego podkastu, bardzo dziękuję za każde wsparcie!Zapraszam również na Facebooka, Twittera i Instagrama, każdy lajk i udostępnienie pomoże w szerszym dotarciu do słuchaczy, a to jest teraz moim głównym celem :) Na stronie Naukowo.net znajdziesz więcej interesujących artykułów naukowych, zachęcam również do dyskusji na tematy naukowe, dzieleniu się wiedzą i nowościami z naukowego świata na naszym serwerze Discord - https://discord.gg/mqsjM5THXrŹródła użyte przy tworzeniu odcinka:Russell C, Baker P, Grimes C, Lindberg R, Lawrence MA. Global trends in added sugars and non-nutritive sweetener use in the packaged food supply: drivers and implications for public health. Public Health Nutrition. 2022:1-39. doi: https://doi.org/10.1017/S1368980022001598Seo Eun Yang, James D Wilson, Zhong-Lin Lu, Skyler Cranmer, Functional connectivity signatures of political ideology, PNAS Nexus, Volume 1, Issue 3, July 2022, pgac066, https://doi.org/10.1093/pnasnexus/pgac066Poulin, A., Aeby, X. & Nyström, G. Water activated disposable paper battery. Sci Rep 12, 11919 (2022). https://doi.org/10.1038/s41598-022-15900-5R. Austin Hicklin, Linda Eisenhart, Nicole Richetelli, Meredith D. Miller, Peter Belcastro, Ted M. Burkes, Connie L. Parks, Michael A. Smith, JoAnn Buscaglia, Eugene M. Peters, Rebecca Schwartz Perlman, Jocelyn V. Abonamah, Brian A. Eckenrode. "Accuracy and reliability of forensic handwriting comparisons". https://doi.org/10.1073/pnas.2119944119Dong Hoon Lee, Leandro F.M. Rezende, Hee-Kyung Joh, NaNa Keum, Gerson Ferrari, Juan Pablo Rey-Lopez, Eric B. Rimm, Fred K. Tabung, Edward L. Giovannucci. "Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults". https://doi.org/10.1161/CIRCULATIONAHA.121.058162

Denis Rancourt, PhD will join us to talk about his landmark study into All-Cause mortality in the US, and what it tells us about the Covid Pandemic. Michael van Zanten will talk about how the church is changing in Canada. Show Resources All of my content is completely, 100%, viewer supported and funded. Thank you for your kindness to keep information like this coming.  Fear is the Virus t-shirts Donate at: www.lauralynn.tv Go Get Funding : https://bit.ly/2uZw7cD Patreon:  https://www.patreon.com/LauraLynnThompson E-Transfer to Email: lauralynnlive@gmail.com Twitter: @LauraLynnTT Facebook: Laura-Lynn Tyler Thompson Parler: @LauraLynnTT Bitchute Twitch Dlive Flote Rumble Mobcrush

FFR-guided PCI, ISCHEMIA trial challenged, QFR, and one of the most important studies of 2021 are discussed by John Mandrola, MD, in this week's podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I - FFR-Guided PCI - FFR-Guided PCI Falls Short vs CABG in Multivessel CAD: FAME 3 https://www.medscape.com/viewarticle/962274 - Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery https://www.nejm.org/doi/full/10.1056/NEJMoa2112299 - The fallacies of fractional flow reserve https://pubmed.ncbi.nlm.nih.gov/31889563/ II - ISCHEMIA-Trial Challenged - How Applicable is ISCHEMIA Trial to US Clinical Practice? https://www.medscape.com/viewarticle/962233 - Comparison of Patients Undergoing Percutaneous Coronary Intervention in Contemporary U.S. Practice With ISCHEMIA Trial Population https://www.jacc.org/doi/full/10.1016/j.jcin.2021.08.047 - The Glass Is at Least Half Full https://www.jacc.org/doi/10.1016/j.jcin.2021.08.054 - Initial Invasive or Conservative Strategy for Stable Coronary Disease https://www.nejm.org/doi/full/10.1056/nejmoa1915922 III - QFR - FAVOR III China: QFR-Guided PCI Shows Advantage Over Angiography https://www.medscape.com/viewarticle/962328 - Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial https://doi.org/10.1016/S0140-6736(21)02248-0 Features: - The MI–Mortality Mismatch: When Lowering MI Doesn't Extend Life https://www.medscape.com/viewarticle/962276 - Assessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2785560 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Un nouvel épisode du Pharmascope est disponible! Dans ce 79ème épisode, Nicolas, Sébastien et Isabelle, inspirés par une populaire série documentaire, abordent l'utilisation des thérapies hormonales en ménopause. Les objectifs pour cet épisode sont: Expliquer le concept d'hormones bio-identiquesDiscuter des bénéfices et des risques associés à l'hormonothérapie en ménopauseConseiller adéquatement une patiente sur la prise d'hormones dans le traitement de la ménopause Ressources pertinentes en lien avec l'épisode Série documentaire Loto-MénoProduit par KOTV, 2021. Disponible sur l'EXTRA d'ICI TOU.TV Revues systématiques portant sur l'efficacité et l'innocuité de l'hormonothérapieMaclennan AH et coll. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004;2004:CD002978. Gaudard AMIS et coll. Bioidentical hormones for women with vasomotor symptoms. Cochrane Database Syst Rev. 2016;(8):CD010407. Rubinow DR et coll. Efficacy of estradiol in perimenopausal depression: so much promise and so few answers. Depress Anxiety. 2015;32:539-49. Lethaby A et coll. Hormone replacement therapy for cognitive function in postmenopausal women. Cochrane Database Syst Rev. 2008;2008:CD003122. Boardman HMP et coll. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev. 2015;(3):CD002229. Marjoribanks J et coll. Long-term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2017;1:CD004143. Études WHIRossouw JE et coll. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321-33. Anderson GL et coll. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291:1701-12. Manson JE et coll. Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials. JAMA. 2017;318:927-38. Étude WISDOMVickers MR et coll. Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women. BMJ. 2007;335:239. Autres référencesHoibraaten E et coll. Increased risk of recurrent venous thromboembolism during hormone replacement therapy--results of the randomized, double-blind, placebo-controlled estrogen in venous thromboembolism trial (EVTET). Thromb Haemost. 2000;84:961-7. Rowe T. A Word About Bioidenticals. J Obstet Gynaecol Can. 2016;38:697-9. Plourde R, Tan R. L'hormonothérapie de remplacement. Quand, pour qui et comment? Le Médecin du Québec. 2020;55:41-6.

@fabiodominski Fonte: Zhao Y, Hu F, Feng Y, Yang X, Li Y, Guo C, Li Q, Tian G, Qie R, Han M, Huang S, Wu X, Zhang Y, Wu Y, Liu D, Zhang D, Cheng C, Zhang M, Yang Y, Shi X, Lu J, Hu D. Association of Cycling with Risk of All-Cause and Cardiovascular Disease Mortality: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies. Sports Med. 2021 Cepeda, M., Schoufour, J., Freak-Poli, R., Koolhaas, C. M., Dhana, K., Bramer, W. M., & Franco, O. H. (2017). Levels of ambient air pollution according to mode of transport: a systematic review. The Lancet Public Health, 2(1), e23-e34. Tainio, M., de Nazelle, A. J., Götschi, T., Kahlmeier, S., Rojas-Rueda, D., Nieuwenhuijsen, M. J., ... & Woodcock, J. (2016). Can air pollution negate the health benefits of cycling and walking?. Preventive medicine, 87, 233-236. De Hartog, J. J., Boogaard, H., Nijland, H., & Hoek, G. (2010). Do the health benefits of cycling outweigh the risks?. Environmental health perspectives, 118(8), 1109-1116. Alessio, Helaine M.1; Reiman, Timothy1; Kemper, Brett1; von Carlowitz, Winston1; Bailer, A. John2; Timmerman, Kyle L.1 Metabolic and Cardiovascular Responses to a Simulated Commute on an E-Bike, Translational Journal of the ACSM: Spring 2021 --- Support this podcast: https://anchor.fm/fabio-dominski/support

Elevated blood glucose is one of the earliest and most common indicators of worsening metabolic health, insulin resistance and cardiovascular disease. For our clients, fasting blood glucose and triglycerides are amongst the first things we test to get a snapshot view of metabolic health. We've now added HbA1C - a marker that offers a broader look at glycemic history - to our baseline blood panel, to better evaluate our clients. On this podcast, NBT Scientific Director Megan Hall talks about the HbA1C blood test: what it is, who needs it, and why you should care. Megan talks about the optimal reference range for this test, and when to become concerned about your result (hint: it's sooner than your doctor would have you believe). She also talks about exactly what to do if your A1C is out of range, and how a continuous glucose monitor can help you evaluate your body's response to different foods and other environmental factors. Here's the outline of this interview with Megan Hall: [00:00:48] HbA1C (aka glycated haemoglobin): a marker of your glycemic history. [00:02:27] Glucose to A1C conversion chart. [00:02:52] Megan's outline for this podcast. [00:03:04] Why you should care about HbA1C. [00:03:48] Optimal ranges for HbA1C: 5.0% to 5.4%. [00:04:33] Studies supporting optimal reference range: 1. Zhong, Guo-Chao, et al. "HbA 1c and Risks of All-Cause and Cause-Specific Death in Subjects without Known Diabetes: A Dose-Response Meta-Analysis of Prospective Cohort Studies." Scientific reports 6.1 (2016): 1-11; 2. Schöttker, Ben, et al. "HbA 1c levels in non-diabetic older adults–No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies." BMC medicine 14.1 (2016): 1-17; 3. Li, Fu-Rong, et al. "Glycated hemoglobin and all-cause and cause-specific mortality among adults with and without diabetes." The Journal of Clinical Endocrinology & Metabolism 104.8 (2019): 3345-3354; 4. Pai, Jennifer K., et al. "Hemoglobin a1c is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women." Journal of the American Heart Association 2.2 (2013): e000077. [00:06:12] Prediabetes range: 5.7% to 6.4% (above 6.4% is diabetes). [00:07:06] Only 12% of the population is metabolically healthy; Study: Araújo, Joana, Jianwen Cai, and June Stevens. "Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009–2016." Metabolic syndrome and related disorders 17.1 (2019): 46-52. [00:07:31] Limitations and caveats of the A1C blood marker. [00:08:05] Partial marker of mean glycemic exposure; Article: Bloomgarden, Zachary. "Beyond HbA1c." Journal of diabetes 9.12 (2017): 1052-1053. [00:08:53] Things that cause HbA1C to be falsely low or high. [00:10:14] Study: Virtue, Mark A., et al. "Relationship between GHb concentration and erythrocyte survival determined from breath carbon monoxide concentration." Diabetes Care 27.4 (2004): 931-935. [00:12:36] Racial and ethnic differences: Herman, William H., and Robert M. Cohen. "Racial and ethnic differences in the relationship between HbA1c and blood glucose: implications for the diagnosis of diabetes." The Journal of Clinical Endocrinology & Metabolism 97.4 (2012): 1067-1072. [00:12:42] Other markers of glycemic regulation. [00:12:55] Drawbacks of Glycomark. [00:14:08] Reticulocytes - helpful to calculate RBC lifespan. [00:14:40] Equation: RBC survival (days) = ~ 100 / [Retics (%) / RLS (days)] [00:15:44] Sign up for our group program to get a blood test + bloodsmart.ai report + 4 group coaching sessions + help videos. [00:16:44] Continuous Glucose Monitor (CGM). [00:17:26] Podcast: Continuous Glucose Monitoring to Prevent Disease and Increase Healthspan, with Kara Collier, RDN. [00:17:46] Get $50 off your Nutrisense membership when you support NBT on Patreon. [00:18:26] Studies demonstrating that HbA1C is not the perfect marker: 1. Cohen, Robert M., et al. "Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c." Blood, The Journal of the American Society of Hematology 112.10 (2008): 4284-4291; 2. Wright, Lorena Alarcon-Casas, and Irl B. Hirsch. "The challenge of the use of glycemic biomarkers in diabetes: reflecting on hemoglobin A1C, 1, 5-Anhydroglucitol, and the glycated proteins fructosamine and glycated albumin." Diabetes spectrum 25.3 (2012): 141-148; 3. Dubowitz, N., et al. "Aging is associated with increased HbA1c levels, independently of glucose levels and insulin resistance, and also with decreased HbA1c diagnostic specificity." Diabetic Medicine 31.8 (2014): 927-935. [00:18:58] What to do if your A1C is out of range: Diet, lifestyle, measure other markers, monitor blood glucose. [00:19:35] Cellular vs. acellular carbs. [00:22:25] Simon Marshall, PhD. on stress management: How to Manage Stress. [00:24:19] 4-quadrant model. [00:26:07] Retest after 2-3 months. [00:27:58] Join our group program.

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This issue will review: Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg Autonomous Artificial Intelligence for Diagnosing Diabetic Retinopathy in Youth Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality Effects of iGlarLixi up to 52 weeks in type 2 diabetes Comparative effectiveness and safety of SGLT2 inhibitors vs. GLP-1 receptor agonists in Older Adults Changes in Plant-Based Diet Indices and Subsequent Risk of Type 2 Diabetes   For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

Does weight loss surgery make you thin? What percentage of people is it successful for? Are the side effects worth it and what are they exactly? This episode is a deep dive into bariatric surgery AKA "weight loss" surgery AKA stomach amputation. CW: There are mentions of the O Words, suicide rates, and brief mention of calories. Episode show notes: http://www.fiercefatty.com/050 Let's continue the conversation in my free group! >> https://www.facebook.com/groups/fiercefattyfriends/   Long-term weight regain after gastric bypass: a 5-year prospective study: https://www.researchgate.net/publication/5459557_Long-term_Weight_Regain_after_Gastric_Bypass_A_5-year_Prospective_Study Anti-Diet by Christy Harrison: https://christyharrison.com/book-anti-diet-intuitive-eating-christy-harrison Ethical Questions About Surgery Raised By Scientists: https://jamanetwork.com/journals/jama/article-abstract/196339 Food Junk Science Blog: http://junkfoodscience.blogspot.com/2007/01/junkfood-science-weekend-special.html Suicide Rates: https://bariatrictimes.com/understanding-postoperative-suicide-self-injury/#:~:text=Based%20on%20their%20analysis%2C%20the,3.2%E2%80%935.1%2F10%2C000  Kaitlin Anderle Who Had Surgery: https://www.instagram.com/p/B9B7HwSh3RM/ Roxane Gay - What Fullness Is: https://gay.medium.com/the-body-that-understands-what-fullness-is-f2e40c40cd75 Lindo Bacon on Bariatric Surgery: https://www.lindobacon.com/HAESbook/pdf_files/HAES_Bariatric-Surgery.pdf Prevalence of alcohol use disorders before and after bariatric surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682834/#:~:text=There%20is%20some%20evidence%20that Mineral Malnutrition Following Bariatric Surgery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771134/#:~:text=Bariatric%20surgery%20exacerbates%20preexisting%20malnutrition,with%20micronutrient%20supplementation%20following%20surgery. Substance Use after Bariatric Surgery: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789154/ Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures: https://pubmed.ncbi.nlm.nih.gov/16234496/#:~:text=The%20rates%20of%2030%2Dday,001 All-Cause and Cause-Specific Mortality Associated with Bariatric Surgery: A Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055056/#:~:text=findings%20have%20emerged.-,Bariatric%20surgical%20patients%20have%3A%201 Survival among high-risk patients after bariatric surgery: https://pubmed.ncbi.nlm.nih.gov/21666276/#:~:text=Results%3A%20Among%20patients%20who%20had,and%2015.2%25%20for%20nonsurgical%20controls. Death Rates and Causes of Death After Bariatric Surgery for Pennsylvania Residents, 1995 to 2004: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888907/ No evidence that bariatric surgeries save healthcare costs or save lives: http://junkfoodscience.blogspot.com/2008/09/no-evidence-that-bariatric-surgeries.html Quote from Junkfood Science: http://junkfoodscience.blogspot.com/2007/02/rumor-versus-facts.html “Facts Risks of dying by car: According to the National Center for Health Statistics at the U.S. Centers for Disease Control and Prevention, your annual risk of dying from a motor-vehicle accident is 0.016%. Risks of dying from a bariatric surgery: The most objective mortality data available (on actual deaths among all those who had all types of bariatric surgeries at Medicare-approved centers from 1997 to 2002) found that the first year death rate after surgery was 4.6%. Risks of dying from obesity: Actual mortality rates according to body mass index among a 40-year study of 1.8 million people, found the very fattest 0.2% of women at age 35 had an annual risk of dying of 0.18% (compared to 0.13% for "normal" weight women). So, by having a bariatric surgery even the heaviest woman increases her risk of dying about 45-fold.”  

This likely to be part 1 of many on the topic. In this episode we seek to define what purpose is, why we need it, and how to go about starting to find yours. One of the suggested approaches is based on the concept that your individual personality is at the center of this journey. We've created a simple app, called Own My Life (http://ownmy.life/) to help identify your personality traits, give you some ideas on what those traits mean.References:Purpose in Life and Its Relationship to All-Cause Mortality and Cardiovascular Events - A Meta-Analysishttps://journals.lww.com/psychosomaticmedicine/Abstract/2016/02000/Purpose_in_Life_and_Its_Relationship_to_All_Cause.2.aspxFred Silverstone : Finding Purpose in Lifehttps://www.health.harvard.edu/staying-healthy/finding-purpose-in-lifeDan Pink: Drivehttps://www.goodreads.com/book/show/6452796-driveDan Gilbert: Happinesshttps://blog.ted.com/ten-years-later-dan-gilbert-on-life-after-the-surprising-science-of-happiness/Daniel Kahneman: Thinking Fast and Slowhttps://www.goodreads.com/book/show/11468377-thinking-fast-and-slowSHRM: Job Satisfactionhttps://www.shrm.org/ResourcesAndTools/business-solutions/Documents/2015-job-satisfaction-and-engagement-report.pdfThe Search for Purpose in Life: An Exploration of Purpose, the Search Process, and Purpose Anxietyhttps://repository.upenn.edu/mapp_capstone/60/?utm_source=repository.upenn.edu/mapp_capstone/60&utm_medium=PDF&utm_campaign=PDFCoverPages

This month on Episode 9 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the January 31 and February 14, 2020 issues of Circulation Research and talks with Dr Joe Miano and DrThomas Quertermous about their article Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway.   Article highlights:   Wang, et al. Multi-Omics Integration Study of AF   Heianza, et al. Antibiotics and Risk of Mortality   Dikalova, et al. Sirt3 Reduces Hypertension and Vascular Dysfunction   Hu, et al. Lipid Overload Acetylates Drp1 in the Heart Transcript Dr St. Hilaire: Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, and I'm from the Vascular Medicine Institute at the University of Pittsburgh. Today I'm going to share with you four articles that we selected from the January 31st and February 14th issues of Circulation Research. I'm also going to have a discussion with corresponding authors, Drs. Joe Miano and Thomas Quertermous about their study on the role of TCF21 and smooth muscle cell lineage specificity in coronary artery disease. So first, the highlights. The first article I'm sharing with you is titled, Integrative Omics Approach to Identifying Genes Associated with Atrial Fibrillation. First author is Biqi Wang, and the corresponding author is Honghuang Lin from Boston University School of Medicine in Boston, Massachusetts. Atrial fibrillation, or Afib, is the most common form of heart arrhythmia and in the US alone there's somewhere between three and six million individuals with this condition. AFib can be either idiopathic or inherited, and genome-wide association studies, or GWAS studies, have identified hundreds of genetic loci that are linked to AFib. However, these loci explained only a small percentage of inherited cases. This suggests that there are many more AF related genes yet to be discovered. To try and identify these elusive a-fibrillated loci, this study integrated data from previously performed transcriptome, epigenome and GWAS studies. The TWAS and EWAS, as the transcriptome and epigenome-wide studies are short-handedly called, was collected from more than 150 Afib patients, and over 2,000 control individuals. While existing GWAS data, that's genomic data, was collected from tens of thousands of AFib and control participants. By combining and analyzing the data from these TWAS, EWAS, AND GWAS studies, the team was able to identify an additional 1700 genes that were associated with AFib. Now this is compared to the original 206 loci that were identified by the GWAS studies alone. Many of these new genes are involved in cardiac development as well as the regulation of the heart and the muscle cells. The additional gene hunting power afforded by co-analyzing multiple Omics data is not only helpful for approaching AFib but is really setting a platform upon which future studies might be done to provide novel insights for numerous other diseases of complex ideology. The second article I will highlight is titled, Duration and Life-Stage of Antibiotic Use and Risks of All-Cause and Cause-Specific Mortality, a Prospective Cohort Study. The first author is Yoriko Heianza, and the corresponding author is Lu Qi from Tulane University in New Orleans, Louisiana. So microbiome is a word that is used to describe all of the microbes; the bacteria, the fungi, the protozoa, and the viruses that live on and also live inside the human body. And how our microbiome influences human health as well as disease state is a new and hot research topic. Alterations to the gut microbiome have been suggested to influence the risk of developing certain chronic diseases, including cancer and cardiovascular disease. There are many factors that influence the constituents of the gut microbiome; things such as your diet, your environment, your stress level, but another factor that can significantly alter the gut microbiome is the use of antibiotics. So there's preliminary evidence that suggests long-term antibiotic use may be linked to increased mortality in adult women, and now this study defined that link in more detail. The authors performed a large-scale population study of antibiotic use in middle aged and older women with a follow up period of 10 years. Over 37,000 women who were in middle age or in late age at the start of the study show that long durations of antibiotic use, which was defined as using antibiotics over two or more months, was associated with increased risk of all-cause mortality and of cardiovascular disease-related mortality in late adulthood, even after adjusting for risk factors such as age, lifestyle, diet and obesity. While no such association was apparent in middle-aged women, the risk for older women was more pronounced if they had also used antibiotics during middle life. And middle life is defined as between the age of 40 and 59 years of age. This suggests that risk of mortality due to antibiotic use may be cumulative. While antibiotics are unquestionably beneficial for saving lives, the link is not necessary causative, and the results indicate a potential risk may exist that could be factored into prescription decisions. Obviously, there's much more details that need to be worked out, but this is quite a provocative study. While antibiotics unquestionably saved lives and the link is not necessarily causative, the results indicate a potential risk may exist that could be factored into prescription decisions. Moving to a metabolism theme, the next article I want to share with you is titled, Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress. The first author is Anna Dikalova and the corresponding author is Sergey Dikalov, and the work was completed at Vanderbilt University. Hypertension affects about a third of the global adult population. That's a huge number of individuals. It's a risk factor for stroke, myocardial infarction and heart failure. Although blood pressure lowering treatments are widely available, hypertension remains uncontrolled in about 30% of patients who are on those treatments. A thorough understanding of the complex pathophysiology of the condition would facilitate the search for much needed alternate treatments for this third of patients with hypertension. To that end, these investigators studied the role of Sirt3, which is an enzyme that tends to be at the lower than usual levels in blood vessels of patients with hypertension. Sirt3 regulates metabolic and antioxidant functions, and alterations in either of these functions can contribute to cardiovascular disease and vascular dysfunction. The team showed that mice genetically engineered to over express Sirt3 had healthier blood vessels and lower blood pressure than control animals who were subjected to experimentally induced hypertension. By contrast, Sirt3 depletion was shown to cause vascular inflammation and increased signs of vascular aging in mice. The team also confirmed that humans with hypertension exhibit low levels of Sirt3; however, the mechanism causing Sirt3 to be low in certain people is not clear. These data suggest that boosting Sirt3 may be potential therapy for hypertension; however, of course, more studies must be conducted to thoroughly investigate this. The last article I want to share with you before we switch to our interview is titled, Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. The first author is Qingxun Hu and the corresponding author is Wang from the University of Washington School of Medicine in Seattle, Washington. In the heart, fat molecules are the main energy source. However, excessive lipids caused from diet induced dyslipidemia, AKA eating too much fat, can lead to cardiomyocyte dysfunction. It's known that lipid overload in the heart can cause increased activity of dynamin-related protein one, or Drp1. Drp1 is an enzyme that regulates mitochondrial fission, but exactly how Drp1 becomes activated due to lipid overload is entirely unclear. The authors of this paper confirmed that Drp1 activity and mitochondrial fission are abnormally increased in the hearts of mice fed a high-fat diet, and these mice also exhibit signs of heart dysfunction. They show similar effects in monkeys who were fed a high-fat diet. Interestingly, Drp1 mRNA was not altered in the hearts of mice. However, Drp1 protein acetylation was increased. So this suggests post-translational modifications are regulating its activity in dyslipidemia. The team went on to perform experiments on cultured rat cardiomyocytes, and they found that incubation with saturated fatty acid palmitate led to the acetylation of Drp1, and thus its activation. And this activation resulted in an excess of mitochondrial fission, which reduced cell viability. By contrast, mutation of Drp1 to prevent its acetylation protected the cells. Together, the results reveal the mechanism of how dyslipidemia can contribute to heart cell dysfunction. Further, this data suggests that Drp1 activity or acetylation state could be novel targets for treating obesity-related heart disease. Okay, we're now going to switch over to the interview portion of the podcast. I have with me Dr Thomas Quertermous, the William G Erwin Professor of Medicine and the Director of Research in the division of cardiovascular medicine at Stanford University. And Dr Joe Miano, Professor and Jay Harold Harrison Distinguished University Chair in vascular biology at the Medical College of Georgia at Augusta University. And today we're going to be discussing their manuscript titled Coronary Disease Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway. So welcome to both of you. Thank you for joining me. Dr Miano: Thank you. Dr Quertermous: Thank you. Dr St. Hilaire: So I'm going to start with you, Dr Quertermous. You've been taking a genomics approach to identify factors that contribute to coronary artery disease. And I'm wondering if you could just give us a brief summary of your work thus far and how it brought you to this current study? Dr Quertermous: Well, as you know, the classical risk factors for coronary artery disease and vascular disease in general really only contribute about 30% of the total risk and the remainder has not been studied, and not been investigated, and can't currently be targeted by therapeutics. So the goal is to try and better understand what are the molecular mechanisms in the blood vessel wall that must contribute the remainder of the risk. And so with the advent of genome-wide association studies and the identification of genes and loci, we've been able to begin to uncover the signaling pathways and mechanisms of disease risk. Dr St. Hilaire: And so the one we're most interested in today, this TCF21, you pulled that up out of one of your GWA studies, or how did we get to this? Dr Quertermous: Well, it's an interesting story. I first cloned that gene about 15 years ago when I was trying to understand vascular development, and it's a basic helix loop helix factor, and I was, well, a number of labs at that point in time were cloning this class of transcription factor to try and better understand developmental processes, and so it was one of a number of bHLH proteins that we cloned at the time. I did some work on it and then named it Pod-1 at that point in time, and then lost interest, and went away from it. And then I was involved in the cardiogram genome-wide association study for coronary artery disease, and I was sitting at my desk one night, and I was watching the hits coming in, you know, as we were doing the association, as we were doing the analysis, and I saw this gene, TCF21, and I thought, "Well, I don't really know what the heck that gene is." And so I was going back and forth between our data and a spreadsheet on the web, and I saw that I had published on this gene, and I was like, "Wow, I didn't even know that I had written a paper about this gene." And then it became clear that it was the bHLH factor I'd cloned some time ago. And then knowing what I knew about the development, that this gene is involved in early processes that lead to the formation of the coronary artery, and in particular the development of smooth muscle cells, then I became super interested, and I said, "Okay, my gene, I'm coming back to you. You and me are going to have a great future together." And that was really how I got started. Dr St. Hilaire: It re-found you. Dr Quertermous: It found me, I guess in this case, yes, and so I began then to work very seriously, because it's hard to try and understand mechanisms. And so we had a good starting point. We had a transcription factor so I could quickly identify the targets downstream of that, and I can link it into some cell biology that I already had some insights into. Dr St. Hilaire: That's a really neat story. I like that. It's kind of penicillin-esque. Dr Quertermous: Thank you. Dr St. Hilaire: Dr Miano, those of us familiar with smooth muscle cells appreciate that they are plastic, that they have this ability to kind of switch their phenotypes per se, and those of us familiar with that also then know about the myocardin and serum response factor pathway. But for our listeners who are less familiar with that, could you maybe give a brief background about what myocardin SRF pathway is and what smooth muscle cell phenotype modulation is? Dr Miano: Sure. I wish I could say, as my colleague said, that I cloned one of those factors, but I didn't. I've been interested in SRF since I was a graduate student actually. Actually went to Eric Olson's lab to look for what we affectionately called back then SmyoD, which stands for smooth muscle myo D. So at that time, we didn't understand what the factors were, even the signaling, that directed cells to become differentiated smooth muscle cells. So I went to Eric's lab looking for SmyoD. Of course I didn't find it. I found some other things. Worked a little bit on SRF, but it was actually Daiju Wong in 2000 or 2001 who in a Cell paper described an elegant a way of finding myocardin, what he called myocardin. So SRF myocardin is a transcriptional switch that is necessary and sufficient to make just about any cell a smooth muscle cell. So when myocardin is not present, then smooth muscle cells lose their differentiated state and they become another cell type, depending on who SRF talks to. And so how does a factor that binds a very discrete element like the CArG box, how does it confer cell identity or specific cell states? And it does so through its interaction with these cofactors, one of which is myocardin. And as this paper describes so elegantly, what Tom did in his lab, is that this TCF1 transcription factor, which is DNA binding, unlike myocardin, it does a similar thing in that it competes for SRF binding with myocardin, so it binds myocardin, prevents myocardin's ability to bind SRF, and thereby directs a new program of gene expression. Dr St. Hilaire: Interesting. So it's kind of helping to fine tune that transcriptional regulation. So I always think of smooth muscle cells, they're kind of always in a contractile state when they're healthy, and it's when they're in either unhealthy, or diseased, or a stress state that they're in that more proliferative-like state. And Dr Quertermous, your previous studies have shown that TCF21 is required for the De-differentiation, and proliferation, and migration of smooth muscle cells. However, there was one sentence in the paper that I was slightly confused on and I'm hoping that you can expand about the bigger role of TCF21. And what it said was that TCF21 expression is protective towards human coronary artery disease. And so the data in the paper show that TCF21 inhibits smooth muscle cell contractility. So can you maybe reconcile the bigger mutations or things you identified in the GWAS with the functional activities you're seeing that you presented in the paper, and maybe talk about the timeline in the continuum of atherosclerosis where TCF is maybe good or maybe bad? Dr Quertermous: So this paper is one of a duo of papers, honestly, that the other paper being published in Nature Medicine almost exactly the same time, and so that paper sort of described some of the aspects of TCF21 at a population level and shows that if you look at all of the single base pairs in the genome that regulate disease risk at 6q23.2 and also regulate expression, you can gain an idea of what's the directionality of the expression of TCF21. And those data suggests that the more TCF21 you have, the less your risk of developing coronary artery disease. And Joe and other scientists have worked for a long, long time to characterize this process and characterize the plasticity of this cell type. And note that one can switch the cell back and forth between being a contractile0differentiated cell to a de-differentiated cell, and elegant work by Gary Owens and a number of investigators have profiled the phenotype of the cells that the smooth muscle cell can become if it undergoes this differentiation process. It's not been able to know though up until this point in time whether that's a good process or a bad process. I mean, 15, 10 years ago we thought smooth muscle cells are proliferating, they're creating a space-occupying lesion, they're decreasing the lumen of the blood vessel, and that's got to be a bad thing. And in honesty, I think over the past three or four years, it's been increasingly clear that perhaps the smooth muscle cells are actually doing a good thing. They are stabilizing the lesion, they're creating the fibrous cap, and there's been some nice work correlating the number of smooth muscle cells in the plaque to the risk that that plaque is going to rupture. Dr St. Hilaire: Yeah, that was kind of my next question. Do you think there's more nuance to it's not just contractile, and synthetic? There's much more broader scope and it's not so much a good or a bad smooth muscle cell. Dr Quertermous: I think it depends on the circumstances I guess, but it's important that the smooth muscle cell be able to migrate into the plaque, and begin to produce matrix components which stabilize the plaque, and to form the fibrous cap, and I think if the smooth muscle cell remains in the media as a contractile cell, it's really not able to do those things, right? And so the human genetics data, looking at the directionality, the expression, the different alleles and their expression patterns, and what is the risk allele at? In this region of the genome, it's pretty clear that more TCF21 is good, and what TCF21 does is to promote this phenotypic modulation. And so that suggests that the process as a whole is good. Not just the gene, but what it does. It's really not possible that TCF21 does anything else in the blood vessel wall. It's primarily restricted to the smooth muscle cell. It's not expressed in macrophages, or endothelial cells, or the other cell types that we think are important in the pathophysiology of the disease process. So putting everything together, it looks for the most part, like this is a positive force in the blood vessel wall, this gene and this process. Dr St. Hilaire: Interesting. And speaking to the vessel wall, I thought one of the very cool and really key experiments in the paper was taking your mechanistic in vitro studies into the mouse, and Dr Miano, maybe you could tell us a little bit about how you were able to do that and mutate these smooth muscle specific CArG boxes in a mouse model. Dr Miano: Well, that's a really good question. Again, it's a history. We've wanted to edit CArG boxes, well, mutate back then, for a long, long time, but it wasn't until the CRISPR craze took a foothold that we really recognize now the power of harnessing that and doing the experiments we wanted to do for so long. And so we've previously published on a CArG box in the first intron of the calponin locus, and found that, to our surprise, that a subtle mutation in that element completely abolished expression of calponin into the smooth muscle. So Tom and I were working in parallel and unbeknownst to me, Tom was working on this SRF enhancer in the second intron, and we've known for quite a while that SRF is auto regulated by itself, and there's CArG boxes in it 5-prime promoter, and there's CArG boxes in the interior of the locus as well, including the one in the second intron that Tom describes in the paper here. And so what we've been doing is using CRISPR in the mouse to make these subtle edits in these CArG boxes around the SRF locus. And unlike the affirmation calponin model I just described, if we mutate the two proximal CArG boxes of SRF, we don't see a lot of change in SRF expression. That was really surprising to us, because studies from Bob Schwartz' lab in Houston two decades ago showed those were important, at least in an artificial reporter assay for the autoregulatory loop that he first described. So we moved interior to this CArG box that's really the focus of this paper, highly conserved, much more so than other CArG boxes, and we first deleted the region, which we often do with CRISPR, and found there was a decrease. But we'd like to do more subtle things with CRISPR, which is really the power of this new editing technology. And so we went in and made just, I think it was like four or five base substitutions to create a novel restriction cipher ease in genotyping. And we reported in the paper, you can see that, to compliment Tom's group's data, that in vivo, indeed, that CArG box by itself, nothing else altered within the locus, did cause a, I would call, a substantial decrease in expression of this important regulator. And so that was really our main contribution to this paper. Dr St. Hilaire: Yeah. I know the opportunities are endless, but also complicated and expensive, and I thought this was a beautiful addition to really confirming those mechanistic studies. So I think my next big question is, if TCF21 is,  so important and protective, and perhaps it's upregulation is beneficial, what is regulating it, and do we know how we can potentially modulate this? Dr Quertermous: That's a great question. That's a great question. And so we know a few things; we certainly know that platelet-derived growth factor stimulation of smooth muscle cells will upregulate TCF21, which is sort of surprising. I mean, it's not so surprising, I guess. So we've spent a little time working on that, and there's a micro RNA which regulates the expression level of TCF21, but we haven't spent a lot more time than that, honestly. We spent a lot more time downstream trying to figure out what's the mechanism by which TCF21 works to suppress the smooth muscle contractile phenotype and activate this more de-differentiated migratory phenotype that the smooth muscle cell adopts. So we've not gone upstream, but your question's a really, really good one. We certainly mapped where TCF21 binds across the genome and we've mapped the variation that regulates its expression, and so we've made progress in that direction, and as I said, identified things which are downstream. But we definitely need to spend more time upstream, and I think that's the area of this intersection of molecular science and genomic science, that there are not many groups that really spend much time up above the gene trying to understand. And so we've not spent enough time doing that, and I think that as a community we've not spent enough time doing that, because I think that's where the big payoff can come in terms of therapeutics. Dr St. Hilaire: To that end, I think I'll end with that question. What do you think is the best way that we could leverage your findings in the clinic? Would it be to focus more on the downstream or to try to identify these more upstream factors in TCF21? Dr Quertermous: Well, I think both open up opportunities, right? If we can understand how TCF21 works and what's downstream, and we can activate those processes and activities, then that's good. If we can figure out what's above TCF21, that would be good as well. The danger there is that TCF21 does a lot of things in a lot of different cells in the body. Dr St. Hilaire: So it'd be a little bit harder to focus onto a smooth muscle cell in a plaque than perhaps some of the downstream effects of TCF21? Dr Quertermous: Correct. Right. That's my worry. It's sort of like thinking about TGF beta and you wouldn't really want to try and manipulate TGF beta. Dr St. Hilaire: That's a whole another can of worms. Dr Quertermous: Yeah, it gets you into a lot of difficulties, I think. So we're really pretty focused downstream now and thinking that we can find specific opportunities there that are resident in that smooth muscle cell in the blood vessel that may not be active in other cell types. So that's really our thinking and that's the way we're going. Dr St. Hilaire: Wonderful. Well, thank you so much to both of you for joining me today. I learned a lot and I really thought this was a beautiful, complex, but well-done study, so thank you very much. Dr Miano: Thank you, Cindy. Dr Quertermous: Thank you so much for calming us down, I guess. Dr St. Hilaire: Well, that's it for our highlights from the January 31st and February 14th issues of Circulation Research. Thank you so much for listening. This podcast is produced by Rebecca McTavish, edited by Melissa Stoner, and supported by the Editorial team of Circulation Research. Some of the copy texts for the highlighted articles was provided by Ruth Williams. Thank you to our guests, Drs Thomas Quertermous and Joseph Miano. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your source for the most up-to-date and exciting discoveries in basic cardiovascular research.    

Interview with Sarah Larney, PhD, author of All-Cause and Cause-Specific Mortality Among People Using Extramedical Opioids: A Systematic Review and Meta-analysis

Interview with Sarah Larney, PhD, author of All-Cause and Cause-Specific Mortality Among People Using Extramedical Opioids: A Systematic Review and Meta-analysis

Interview with Benjamin D. Levine, author of Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification

Interview with Benjamin D. Levine, author of Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification

Jane Ferguson:                Hello, welcome to Getting Personal: Omics of the Heart, Episode 22. This is a podcast from Circulation: Genomic and Precision Medicine, and the AHA Council on Genomic and Precision Medicine. I am Jane Ferguson and it's November 2018.                                            Our first article comes from Carlos Vanoye, Alfred George and colleagues from Northwestern University Feinberg School of Medicine and is entitled, High Throughput Functional Evaluation of KCNQ1 Decrypts Variance of Unknown Significance.                                            So a major growing problem in clinical genomics is that following the identification of a variant that is potentially linked to a disease phenotype, without further interrogation, it's really hard to make sense of the functional significance of that variant. Right now, the large number of variants of unknown significance lead to confusion for patients and clinicians alike. To allow for accurate diagnoses and the best treatment plans, we need a way to be able to screen variants to assess their function in a fast and cost-effective manner.                                            In this paper, the authors decided to focus in the KCNQ1 gene, a cardiac ion channel, which can affect arrhythmias. They aim to assess whether a novel high-throughput functional evaluation strategy could identify functional mutations, as well as an in vitro electrophysiological approach. Which is effective, but expensive and time-consuming. Their approach capitalized on an existing automated electrophysiological recording platform that had originally had been developed for drug discovery essays.                                            They selected 78 variants in KCNQ1 and assessed their function using the High-Throughput platform, which coupled high efficiency, cell electroporation with automated plain or patch clamp recording. They compared the results to traditional electrophysiological essays and find a high rate of concordance between the two methods. Overall, they were able to reclassify over 65% of the variants tested, with far greater efficiency than traditional methods.                                            While this method will not work for all genes and phenotypes, the authors have demonstrated an efficient method for functional interrogation of variants. Which may greatly accelerate discovery and conditions such as Long QT or other congenital arrhythmias.                                            The next paper, Nocturnal Atrial Fibrillation Caused by Mutations in KCND2 Encoding Poor Forming Alpha Subunit of the Cardiac KV 4.2 Potassium Channel, comes from Max Drabkin, Ohad Birk, and colleagues at Soroka University Medical Center in Israel. This paper also focuses on cardiac ion channels and the role of mutations in atrial fibrillation.                                            In a family with early-onset peroxisomal AF across three generations, whole XM sequencing revealed a variant in KCND2 encoding the KV 4.2 Potassium Channel, which segregated consistent with autosomal dominant heredity. This variant resulted in a replacement of a conserved [inaudible] residue with an arginine. To investigate functional consequences of this novel variant, they conducted experiments in xenopos laevis oocytes and found that there is decreased voltage depended channel and activation and impaired formation of the KV 4.2 Homotetramer and the KV 4.2, KV 4.3 Heterotetramer.                                            Overall, this study shows that a novel mutation in a conserved Protein kinase C Phosphorylation site within the KV 4.2 Potassium Channel underlies the phenotypes observed in a family of peroxisomal atrial fibrillation. The targeting Atrial KV 4.2 might be an effective therapeutic avenue.                                            Next up, Michael Levin and Scott Damrauer and colleagues from the University of Pennsylvania published an article entitled, Genomic Risks Stratification Predicts All-Cause Mortality After Cardiac Catheterization.                                            They were interested in understanding the utility of polygenic risk scores for disease prediction. They constructed a genome Y genetic risk score for CAD and applied it to individuals from the Penn Medicine Bio-bank who had undergone Coronary angiography and genotyping.                                            They included over 139,000 variants for the 1,500 ancestry subjects who were included and classified them as high or low polygenic risk. Individuals who were classified as high polygenic risk were shown to have higher risk of All-Cause mortality than low polygenic risk individuals despite no differences in traditional risk factor profiles. This was particularly evident in individuals with high genetic risk but no evidence of angiographic CAD.                                            Adding the polygenic risk score to a traditional risk assessment model was able to improve prediction of five year All-Cause mortality. Highlighting the utility of a polygenic score and underscoring traditional risk factors do not yet fully capture mortality risk.                                            The next article entitled, "Bio-marker Glycoprotein Acetyls is Associated with the Risk of A Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients" comes from Johannes Kettunen, Scott Ritchie, Peter Würtz and colleagues from the University of Oulu Finland.                                            GlycA is a circulating biomarker that reflects the amount of Glycated proteins in the circulation. It has been associated with cardiovascular disease, Type 2 Diabetes, and all-cause mortality. In this paper, the authors used electronic health record data from over 11,000 adults from the finish general population previously included in the "FINRISK" and "Dilgom" studies and they tested for a associations between GlycA and 468 different health outcomes over an 8-12 year follow up. They report new associations between GlycA and multiple conditions including incident alcoholic liver disease, chronic renal failure, glomerular diseases, chronic obstructive pulmonary disease, inflammatory polyarthric disease and hypertension.                                            These associations held true even after adjusting for CRP suggesting that GlycA represents an independent biological contributor to inflammation and disease. Their findings highlight potential utility for GlycA as a biomarker of many diseases and underscore the importance future functional and mechanistic studies to understand how GlycA is linked to disease risk.                                            Our last original research article entitled, "Tissue Specific Differential Expression of Novel Jeans and Long Intergenic Non-coding RNAs in Humans with Extreme Response to Endotoxic glycemia comes from Jane Ferguson, Murdock Riley, and colleagues from Vanderbilt University, Columbia University, and the University of Pennsylvania. That first author is none other than me, so I'm not unbiased reader of this particular manuscript, but I'd like to tell you a little bit about it anyway.                                            We were interested in understanding the transcriptional changes that occur in tissues during acute inflammation. As part of the genetics of evoked responses to Niacin and Endotoxemia, or gene study, we recruited healthy individuals and performed an inpatient endotoxin challenge where we administered a low dose of LPS and looked at the systemic inflammatory response. Individuals vary greatly in the degree of their inflammatory response to LPS and we identified high and low responders, men and women, of African and European ancestry, who had responses in the top or bottom 10% for cytokines and fever.                                            We conducted RNA seek and adipose tissue in 25 individuals and CD-14 positive monosites for 15 individuals in pre and two or four hours post LPS samples. We found that the differences in transcriptional response between high or low responders are mostly explained by magnitude rather than discrete sets of genes.                                            So some core genes were altered similarly, in both groups, but overall the high responders mounted a large transcription of response to LPS or low responders rather than mounting an anti-inflammatory response actually just barely responded on the transcription level. We saw clear tissue specificity between manosites and adipose tissue we identified several long non-coding RNAs that were up or down regulated in response to LPS and validated these independent samples one of these link RNAs which we have now named Monosite LPs induced link RNA regulator vile six or Mahler Isle six, with highly regulated by LPs and monosites but not in adipose tissue.                                            We [inaudible] THP-1 monosites and find a significant effect on iOS six expression suggesting that this is a novel link RNA that regulates Isle six expression in manosites potentially through a cd-86 dependent pathway. Overall our data revealed tissue specific transcriptional of changes that correlate with clinical inflammatory responses and highlight the role of specifically incarnate and inflammatory response.                                            Next up is a research letter entitled "Reduced Sodium Current in Native Cardiomyocytes of a Regatta Syndrome Patient Associated with Beta Two Central Mutation" published by Constance Schmidt, Felix Wiedmann, Ibrahim El-Battrawy, Dierk Thomas, and co-authors from University Hospital Heidelberg. They obtained cardiomyocytes from a patient with Regatta Syndrome previous whole XM sequencing had implicated a variant in the Beta Two Syntrophin or "SNTB2" gene as potentially causal in this individual. Expression analysis showed lower SNTB2 expression and atrial tissue of the affected individual compared with controls.                                            They performed electrophysiology on the Microcytes and found reduced peak sodium density and reduced late sodium current. They co-express wild type or mutant SNTB2 in heck 293 T cells and [inaudible] with the cardiac sodium channel NAV-1.5 and found a significant effect on binding which adversely affected sodium currents. This study nicely demonstrates the functional effect of this SNTB2 mutation underlying Regatta Syndrome in this patient.                                            A second research letter comes from A.T. van den Hoven and Jolien Roos- Hesselink and colleagues from Erasmus University Medical Center in the Netherlands and is entitled "Aortic Dimensions and Clinical Outcome in Patients with SMAD three mutations, they were interested in understanding how the Aortic dilation comment individuals with SMAD three mutations compared to individuals with other syndrome and causes of Aortic dilation.                                            In 28 patients with SMAD three mutations, there were significant growth in the Sinotubular Junction the ascending Aorta on the diaphragm over an average of 10 years of follow up at reads far higher population averages but lower than might be seen in other syndromes, such as [inaudible]. Intensive management and preventive surgery and many of the patients prevented any mortality in this group.                                            Rounding out this issue is a clinical letter entitled "Concealed Arrhythmogenic  Right Ventricular Cardiomyopathy in Sudden unexplained Cardiac Death events from Jodie Ingles, Chris Semsarian, and colleagues from the University of Sydney, Australia. They report on for clinical cases where individuals presented in early adulthood with unexplained cardiac arrest, which was later found to be attributable to mutations in the PKP2 gene. PKP2 or, Plakophilin 2, encodes an integral component of the Desmosome, which is important and Cell-Cell adhesion. Further PKP2 is involved in transcriptional activation of genes controlling intracellular calcium cycling. This gene has been implicated arrhythmogenic right ventricular cardiomyopathy in individuals with cardiac structural abnormalities. These four cases where unrelated individuals were all fans to have loss of function variants and PKP2 underlying sudden cardiac death or events, despite structurally normal hearts. This prompts questions on the clinical management of such cases of concealed ARVC.                                            That's all from us for November, thanks to all of you out there listening. We'll be back in December for the final episode of 2018.                                            This podcast was brought to you by Circulation Genomic and Precision Medicine and the American Heart Association Council on Genomic and Precision Medicine. This program is copyright American Heart Association 2018.                                             

We launched the Blood Chemistry Calculator six months ago and have come to rely on it for our Elite Performance Program clients as an initial screening tool and measure of ongoing progress. With the input of 39 basic blood chemistry markers, the calculator uses a machine-learning algorithm to predict health status in 6 specific areas: immune balance, toxicity, metabolic health, nutrition, oxidative balance, and a general 5-year wellness score. On this podcast, Tommy and I are talking specifically about the Immune Balance Score, the domain that forecasts immune system health and inflammation from 13 out of the 39 input markers and one forecasted value (CRP). Tommy discusses these markers in detail, citing research that supports using them to predict health outcomes. He also shares ideas for next steps to improve functioning in the area of immune balance. You can now try some features of the Blood Chemistry Calculator for free by visiting bloodcalculator.com and clicking “Free Report”. Here’s the outline of this interview with Tommy Wood: [00:00:30] Florida Institute for Human & Machine Cognition (IHMC); Podcast: Optimal Diet and Movement for Healthspan, Amplified Intelligence and More with Ken Ford. [00:00:49] Blood Chemistry Calculator. [00:01:03] Peer Review. [00:02:32] Immune Balance Score. [00:04:00] Dashboard of Blood Chemistry Calculator scores (example). [00:04:08] Predicted Age Score. [00:05:12] Who is the calculator for? [00:06:09] Building a health coach referral network. [00:07:05] Podcast: How to Measure Hormones, with Mark Newman. [00:08:31] Combining 2+ reports for longitudinal tracking. [00:09:08] Markers that make up the Immune Balance Score. [00:10:49] Sensitivity and specificity. [00:13:40] All-cause mortality: dying from any cause. [00:17:05] Evaluating scientific research: PubMed + Google. [00:19:53] C-Reactive Protein (CRP) > 0.5 associated with 75% increase in all-cause mortality; Study: Li, Yunwei, et al. "Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: a meta-analysis." Atherosclerosis 259 (2017): 75-82. [00:21:10] Jeremy Powers; Podcast: National Cyclocross Champion Jeremy Powers on Racing, Training and the Ketogenic Diet. [00:22:30] Dr. Bryan Walsh - Timing of blood testing for athletes. [00:24:49] Albumin: less than 4 g/dL = increased risk of all-cause mortality; Studies: 1. Fulks, Michael, Robert L. Stout, and Vera F. Dolan. "Albumin and all-cause mortality risk in insurance applicants." J Insur Med 42.1 (2010): 11-17; 2. Proctor, Michael J., et al. "Systemic inflammation predicts all-cause mortality: a glasgow inflammation outcome study." PloS one 10.3 (2015): e0116206; 3. Lee, Won-Suk, et al. "Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations." (2018). [00:27:25] Gamma Gap (globulins): > 3 g/dL = increase in all-cause mortality; Studies: 1. Juraschek, Stephen P., et al. "The gamma gap and all-cause mortality." PloS one 10.12 (2015): e0143494; 2. Yang, Ming, et al. "The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians." Scientific reports 8.1 (2018): 1046. [00:29:58] Table that shows reference ranges, scores assigned. [00:30:39] Ferritin - iron overload vs. indicator of inflammation; >200 ng/mL = 50% increase risk of all-cause mortality; Study: Kadoglou, Nikolaos PE, et al. "The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing." PloS one 12.6 (2017): e0178994. [00:34:20] Iron overload podcast: Iron overload and the impact it can have on performance and health, with Dr. Tommy Wood; Blood donation. [00:34:37] Podcast: Rethinking Positive Thinking, with Gabriele Oettingen. [00:36:31] Hemoglobin - higher = more aerobic power; Lower = chronic inflammation or nutritional deficiency.   [00:37:27] Hemoglobin has U-shaped curve - increased all-cause mortality if too low or too high. Optimal: from 14.5 g/dL (13 for women) + 1.5-2 g/dL; Study: Fulks, Michael, Vera F. Dolan, and Robert L. Stout. "Hemoglobin Screening Independently Predicts All-Cause Mortality." (2015): 75-80. [00:39:02] Christopher Kelly’s combined report. [00:39:18] Fasting blood glucose: >100 mg/dL = higher all-cause mortality. Study: Bjørnholt, JØRGEN V., et al. "Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men." Diabetes care 22.1 (1999): 45-49. [00:40:57] Red Cell Distribution Width (RDW): ideal is below 12%; Study: Al-Kindi, Sadeer G., et al. "Red Cell Distribution Width Is Associated with All-Cause and Cardiovascular Mortality in Patients with Diabetes." BioMed research international 2017 (2017). [00:41:17] White Blood Cells. [00:41:28] Eosinophils >0.275 x10E3/uL= increased risk of 30-year all-cause mortality; Study: Hospers, Jeannette J., et al. "Eosinophilia is associated with increased all-cause mortality after a follow-up of 30 years in a general population sample." Epidemiology (2000): 261-268. [00:42:21] Ratios between markers. [00:43:20] Platelets - High is associated with increased risk of mortality after heart attack; Study: Tsai, Ming-Tsun, et al. "U-shaped mortality curve associated with platelet count among older people: a community-based cohort study." Blood 126.13 (2015): 1633-1635. [00:43:39] Lymphocyte:Monocyte ratio; Study: Xiang, Fangfang, et al. "Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study." Hemodialysis International 22.1 (2018): 82-92. [00:45:23] Where to go from here?   [00:45:40] Acute vs. chronic inflammation. [00:47:07] Antimicrobials: Monolaurin, Lauricidin, Selenomethionine; antibody testing. [00:47:40] Malcolm Kendrick Podcast: Why Cholesterol Levels Have No Effect on Cardiovascular Disease (And Things to Think about Instead). [00:48:51] bloodcalculator.com; Quest lab locator. [00:49:11] UK: Fibrhealth. [00:49:15] Australia: https://stephenanderson.com.au/nbt/; Podcast: How to Get Help and Feel Great in Australia Using Advanced Blood Interpretation, with Stephen Anderson.   [00:49:38] support@nourishbalancethrive.com