Podcasts about Mendeley

Play Episode Listen Later Jan 12, 2021 54:30

0:00 Hello, everyone, welcome to the gut check project gut check project fans, KBMD health family, how are you doing? It is now time for episode number 47. I'm here with my awesome co host, Dr. Kenneth Brown. 0:13 What's up Episode 47. This is part two of our immunology. So this is I'm pretty excited. Because just this morning, you said you better check out Joe Rogan this morning because Dr. Mark Gordon is on there. And this dude was saying everything that we've been talking about, but I feel like we even have it to the next level. So we're talking to scientists that understand the whole concept of functional nutrition, functional things that I felt like he was saying, everything that we've been talking about now for quite a while like yours0:45 is no doubt the coolest thing is another thing that we'll we'll get to it in a moment. But it's it's all about eating right. having great nutrition, he used an incredible example of India, where Let's face it, a lot of people don't have the economic means that we do here in the United States. However, they're facing COVID, they have the same health issues that we do here, roughly, and they've got a large population. So when comparing apples to apples are talking about nutrition, and there's some specific things in that nutrition when you say,1:17 oh, and we're gonna get into that, in fact, I got an article here that we're gonna go over and I'll spoiler alert for you. But it's exactly what what what we're talking about right now. So we got some feedback. I apologize to everyone the last podcast we did, we were trying some unique things. And we didn't have such good sound quality, but that's what you get when your sponsor is lousy Lavalier comm so we had LousyLavalier.com Yeah, so we dropped them. And so I'm happy to announce that we got a new sponsor, which we did get a new sponsor, and this is awesome. It's actually a hot dog company. They're called diarrhea dogs. And their slogan is, we're not sure what's in the dog, but we know it will give you diarrhea. Yeah. who's who's betting our sponsor?2:05 The cool thing is, is it's a it's a host specific sponsor, so I'm looking for you to tell me how I2:11 know seriously, who in the company is? Is it Mike? is Mike getting sponsors for us, Mike, because I've already cashed a check. We got to keep talking about diarrhea dogs.2:18 It's, I can't this can't keep happening.2:20 We had lousy Lavalier as a sponsor, then we followed up with diarrhea dogs, yeah. Oh, my goodness,2:25 this is not working out.2:26 We're gonna have a little talk with Barry Weiss. How you been man?2:30 doing well, so we're into a brand new year now. What brief amount of time had a great vacation with the family? And it really just in time, right. I mean, there's, everything's kind of limited on what you can do. Yeah. But we it was, it's good to always have the older son come home spend time with him. We started building some furniture over the last couple weeks. So it's a great bonding experience with me and the boys. And of course, Maria is telling us what she wants us to look like. So trying hard to make it. Yeah. But you know, it's it's been a lot of fun. Mac is in the swing of basketball. And so life, normal life is starting to take on a new meaning. But it's it's good.3:09 Yeah. What about you? Well, for us, um, you know, the, the whole COVID lockdown, you start looking at your house a little bit. And so loida kind of convinced me that maybe we should start considering making a few little changes. And it started out with the master bath. And she's like, you know, shoot, can I do a few other things? I'm like, Yeah, absolutely. So I'm really busy with work and come back. And then you know, next thing I know, the builders or the contractors there and he's like, Look, okay, so this is what we've designed. Here's the plans, bla bla bla bla bla, and, you know, he's like, we're gonna buy the neighbor's house and we're gonna, you know, tear, tear this one down. But I mean, it was just I'm like, Whoa, we're doing a lot of work here. So I'm already in it. We're gonna be in this house for a long time. It's a great area. You notice everybody's moving to Texas. They definitely dragons bringing everybody down here. So following him. So at3:54 any point, did you have a spreadsheet that said, redo house or simply burn house?4:01 Well, then it's like one of those shows. Like once you see the plans, you're like, Oh, yeah, I want it to look like that. But you know, and oh, guess what I did today was that guess what I did? 30 seconds ago. Oh,4:12 I know what you did? Yeah, you got into crypto.4:15 So as we're setting up to do this show, we started having a conversation about cryptocurrency and Bitcoin and people have been telling me to get involved. So in a spur of the moment, while Eric was setting up the mics and everything I bought some Bitcoin Yeah, go Bitcoin.4:29 Yeah. And and we need to probably have a disclaimer that we know nothing about cryptocurrency. Oh, absolutely. Nothing nice. But yeah, it was really kind of cool to watch you do it.4:36 Yeah. So we've covered our sponsors. A little word with the person that's choosing them in the future. And so let's jump into the immune episode part two. So even if the audio is a little bit off on that last one, I encourage everyone to look at our last podcast, because I do a detailed explanation in or at least detailed for a simple country butt Dr. That's living in Texas for the innate immune system, and I actually rewatched it when we were getting the comments great information, audio bad. And at the very end, I go, so that covers the adaptive immune system. I'm like, No, I should have no it was the innate, we did not cover the adaptive yet. There's a reason why that's coming, because then we're going to lead into the vaccinations for COVID and things. Right. So that was the innate. But here's what's really cool. We're gonna talk about what Dr. Mark Gordon was talking about on Joe show. And it's super cool. Like we've been on top of this the whole time. It's been it's it's actually huge, huge news for everyone.5:36 I think a lot of people can learn a lot about what they can do just to protect themselves. And let's small preface, you don't have to just apply the knowledge that you'll pick up today to COVID. COVID actually can begin to fit into other viruses with this talk that we're going to have today.5:52 Yes. And specifically, this is not a COVID talk. We're not saying that at all. What we're saying is we're gonna talk about how to optimize a well running immune system. Yeah. And so when I talked to some of my colleagues and people discuss different things, Angie, and I were talking that she's like, have you looked at our Mendeley account? So Mendeley is where we put all our articles, and I just did a quick look. We have over 1000 articles regarding immune health and how to optimize it through nutrition and lifestyle. Yeah. So even that is science backed. Everything we're talking about here is completely science backed. In fact, one of the things I wanted to discuss because I think it's really cool is this article that just came out in 2020. It's called the antiviral functional foods and exercise, lifestyle prevention of Coronavirus. That's a very boring title. And those are the kinds of things that I read. And it was published in the Journal of nutrients. What's fascinating about this is that they discuss the things that other people are now just finally starting to talk about. Yeah, so I want to review this article really quick. Then I want to get back to the whiteboard. And hopefully sound a little bit better.7:06 We're gonna use headphones today.7:07 Yeah, we're gonna try and use headphones. I got a new mic attached to a hemorrhoid bander because I feel very comfortable holding hemorrhoid banders. Yeah, so that is dry tone right there. That is right there. 7:20 that's almost as good as the Bob Barker microphone from the remember the little skinny one that he had on7:28 the show? Yeah, when they tell you to go spay and neuter your dog.7:31 Yeah. spay and neuter your dog spin the wheel. Drive. I can't wait. I had a hard time of that. Anyway. Yeah. Yeah. Great show.7:37 So basically, on this article, it's really interesting. Not actually not interesting. For us. It was it just reiterated everything that we've kind of base talking about. What they looked into was functional foods. They called it functional foods, and physical exercise. So the exercise part was a brief part than 90% of the article was talking about functional foods, which they described as functional foods being polyphenols.8:02 Incredible.8:02 So the functional foods are polyphenols because of the various mechanisms that they do in the body. We got contacted by an author of the sirt diet. That's sirtuins. And he noticed that we've been talking about polyphenols and said, Wow, you guys are on that. So the whole thing about Adele's diet that she lost all that weight, that's called the sirtuin diet or the sirt diet. And then I've watched it on Dr. Oz. And I was like, there's something about polyphenols, polyphenols. And the reason why is you're gonna see on this whiteboard, how many different ways a functional food like a poly phenol can benefit you definitely. And so the cert diet just means that you turn on certain genes, it's an epigenetic thing. So really quick on the exercise. No big surprise, as it turns out, exercise is pretty good for you. Sure. So they looked at different aspects of it. And what it does do is it does activate natural killer cells, and will induce monocytes to become antigen presenting cells like dendritic cells. If you go I don't know what that is. We talked about that on the last episode. And we're going to get to it again here. So don't worry. That being said, super extreme exercise, which we have talked about this can actually lower your immune system. So many times when people train super hard, and we're talking about like, marathons and triathlons and marathon running. I've had so many patients that get very sick after they really train for something, they go all out, and then they get sick. And it's because I didn't even realize this, that you produce so many reactive oxygen species. This damages cells, which leads to inflammation, you're gonna hear this term over and over again. And then it actually adversely affects your white blood cells ability to fight off infections. Yeah. So the real idea is that regular exercise is really good for you. It gets rid of old immune cells that don't work very well. And you actually stimulate young healthy cells that can actually have a young, healthier immune system. It has been shown that highly conditioned athletes have a much better functioning innate immune system, as opposed to sedentary people. Yeah. So when we're sitting in a viral season, and if you're sedentary and you're overweight, and you got diabetes and high blood pressure, your immune system doesn't work as well. And there's reasons for this in this paper. So then they kind of went through that they're like, yeah, okay, so exercise is good. And then they go into 90% of the rest of the article is discussing polyphenols and the multiple areas that these functional foods benefit our immune system. Okay. And, oh, we're probably jumping ahead. What's a polyphenol?10:40 Oh, what is it polyphenol? Yeah, tell everybody what a polyphenol islittle compounds that are found. And fruits and vegetables. Generally they are what can be responsible for the coloration that's inside those fruits and vegetables. And they they're naturally occurring. Some of them are large, or small. But in essence, our bodies love them.10:59 Absolutely. So I always refer to them as mother nature's secret weapon. This particular article goes into great detail about how the flavonoids, terpenoids alkaloids in the polyphenols, so they can go into that are actually bio active, they can influence genes have peptide qualities, and are broken down by our microbiome into potent anti aging, anti inflammatory, anti cancer metabolites.11:25 Right. You know, I was thinking about this, how do we bring validation to this part of this study, or the I'm sorry, the discussion, I guess, whenever we're talking about this to people, because I started thinking about, if someone years ago when you were when you were young, and someone said, you probably need more calcium to make your bones strong, you didn't just go to the store and buy sack of calcium, you generally just started drinking more milk or something similar. Or if you were an athlete, and you knew that you needed to make sure that you didn't get cramps, you ate bananas, or ate spinach, all of that stuff, you didn't go and just buy the little element, those elements are naturally occurring in something that you're eating or drinking. That's essentially what we're trying to talk about with polyphenols is there are small little things in there that your body craves, just like your bones want calcium, the these are the vehicles, these are the foods that will deliver what your body wants to maintain health and keep you healthy 100%. And they mentioned how versatile polyphenols are.12:24 Oh yeah, meaning they function in many different ways. Number one, they can have potential influence on your gut barrier, where they improve the immune system of the gut barrier, the first portion of that, then they actually have epigenetic phenomenon. Most important is that your microbiome will break these things down to beneficial products. And that's going to be something that we've talked about post biotics before, I'm very excited. We've contacted this a PhD in Argentina, who has one of the most amazing articles describing the post biotic effect. And they actually demonstrate that the larger, more complex polyphenol is the best way to consume it. In other words, yeah, you don't want to take the one little molecule. So that's pretty much what they said about polyphenols, because we're gonna talk a lot more about that. And then it kind of like briefly go over Oh, and then there's vitamin D, which is pretty good for y'all. So vitamin D deserves its own show, because it's more like a hormone than it is like a vitamin here. And then they look at a couple other things like vitamin C and stuff, and they kind of gloss over it. And then they come back to the polyphenols. And they're like, and then they reference to the viruses. And they show how there's so much information out there about how these polyphenols actually influence the destruction of multiple viruses like influenza, Zika, virus, HSV, and Corona.13:45 And there's a mechanism to and there's13:47 a mechanism for each one of these. So the conclusion is, and this is, I hate to say Joe Rogan, for the third time in about first five minutes, it'll validate what we say. He's always said, why aren't we discussing ways to improve our immune system, prevent ourselves and do this, these guys end the whole article, and by the way, it's thick 20, some pages with references and everything they end it with the conclusion is, this is a pretty cheap and simple way to improve your immune system or optimize, get some exercise, eat some polyphenols and get a little sun. Yeah, that was the combination of it. All right. And and these people put a lot of work into that. And that that's a spoiler alert.14:31 I think I might have said though it's really, really important is that there's a lot of work. There's a lot of research, there's a lot to take in here. However the solution if you really think about it, it isn't that difficult to adhere to this to keep to keep people healthy. That's actually the coolest part. The summary of it all is polyphenol, sleep exercise. You're off to an incredible start just with that and don't i don't think you should shy away from Rogan at all. He supports tons of other podcasts gives huge mentions to other people. They're doing the same thing. When I heard Dr. Mark on this morning with him, I just I liked it because it not only was somebody else talking about the same subject, but he was doing it in such detail that we like to talk about it, that I encourage you, we're not the only ones who have this level of research and are seeing these kinds of results with people.15:22 Oh, it's so cool. And now because we're in these circles with these PhDs, I'm getting preliminary data on different studies where it's humans, where they're looking at what I'm going to talk about here. Yeah. So what I thought we could do is try and do round two, you put some headphones on, 15:37 I'm going to have to,15:38 I'm going to grab my Bob Barker mic right here. I'm going to turn this one15:46 that was kind of quiet. And now I'm going to come back like this. There he is. This is why we have headphones. This is15:52 why we have headphones. And now I'm going to switch the cameraprobably should have you looked at the computer to make sure that I'm in focus and everything. And now, let's do a recap of the last. And that's not a window of the last podcast that we did. This is a kind of quicker version of what we did. And this is to get everybody up to speed because when we talk about polyphenols, we need to make sure that you understand exactly what's going on and why there are functional food. So just to recap, the innate immune system is your response to any type of damage, whether that damage is through physical damage, whether that damage is through infection, whether that damage is through repeated poor diet choices, your body is going to try and repair itself. So let's walk through what happens. The first step, step one, let's just assume that you have an infection. If you have a virus or bacteria, what it will do is it will attack a cell. So that cell no matter what it is, sounds an alarm. And it notifies its neighbor, which is kind of its bodyguard, the mast cell. The mast cell then releases what is called braided cinan. This is really neat, because if you ever sprained an ankle or done anything, this is what's going on. The braided cinan send different proteins or cytokines to the blood vessel. First step is the blood vessel. And what it does is it actually normally the blood vessels have very tight seals, what it does is the blood vessels pull apart a little bit to allow fluid to come out. Well, the reason for that is is that you want the swelling to contain whatever's going on. You sprained an ankle, you go oh my gosh, look at my ankle, it's so swollen, well, it's there for a reason, because that fluid is trying to concentrate what your body needs in the same area. So the fluid starts coming out step to these braded cinan, and different other cytokines send up little flags, just like Velcro sticks. And these are called intercellular adhesion molecules. And what they do is they grab white blood cells that are swimming by so these white blood cells have these little hooks and they get hit and they stop and they go, Oh, what's going on all the fluids going out that way, I'm gonna go out that way. So then the white blood cells join this little party over here. This is what ends up causing redness, swelling and pain anytime you have any type of infection, anytime you have any type of injury. So now we have these white blood cells, what they do is they go, Oh, that mast cell told us to go that way. And so the white blood cells head over to what's going on. And then this allows your body to fight the intruder that's doing this. So that's step one. So now these white blood cells come around. You heard me say in that other study the antigen presenting cells. So one of these types of cells, which is a phagocyte, will actually first thing it does is it swallows the invader, bacteria, virus, fungus, whatever it is, swallows it, and the reason why does it it digests it, and then it breaks it apart and goes, Okay, this is what it looks like. So it puts wanted posters on its outside. So this guy said, I know what's attacking us now, this, this guy right here. So these antigen presenting cells, put it on the outside, and then they do something else. They release cytokines, specifically, multiple cytokines, but the important ones are TNF alpha, interleukin six, interleukin one, interleukin eight, and you're going to hear a lot more about this, because I'm talking to scientists all over the world. And people are now studying specifically how we can use functional foods to control this response. So TNF alpha, does a lot of things. It's a pro inflammatory cytokine. And so we know that TNF alpha is used in very expensive drugs block that for rheumatory arthritis for Crohn's disease for ulcerative colitis for all of that. So TNF alpha does something kind of interesting that I found unique is it actually goes to the hypothalamus and it increases your core body temperature. So when I say these are bad, they're really good for you in small amounts, it's when it becomes too much that it becomes bad. So TNF alpha hits the hypothalamus increases, and that's how you get fever, interleukin six, it goes to the bone marrow and increases the white blood cells. So this is why you have that achy feeling if you've ever had the flu, or if you're gonna get a vaccine, and you go, Oh, my gosh, I had a vaccine, that kind of hurt, I feel like I have a low level flu. It's because the bone marrow is producing more white blood cells. interleukin one goes to the liver to produce acute inflammatory reactance, which goes into something called the complement system. But that inflammation is what we measure in people. In fact, cardiologists use this all the time they look at C reactive protein, yeah, because when you have inflammation, the liver produces this. So people with coronary disease will have increased levels of that, and then interleukin eight.Fascinating, it basically produces more of those little Velcro hands. So then we come all the way back to the blood vessel. And now we've got dilation, fluid coming out. And every white blood cell that's coming through gets grabbed. So when you have the white blood cells producing here, you've got the fever, which increases the amount of blood flow heart rate is faster, everything. It's an phenomenal and just beautiful little system. Yeah, it is. And when it works great. It's exactly what we need. It's exactly what you need. In the acute phase. Definitely the innate immune system is here to protect you in the first phase. So now step three of the innate immune system out of you, but that's the antigen presenting cell, the one that we were talking about over here, sometimes they sometimes they get overwhelmed, and the virus actually wins. So the poor little guy dies. It's that's a good cartoon. Yeah, so the poor guy dies here. So the antigen presenting cell dies. So it leaves rubble, so it's comes out and the body even gets that. So reactive oxygen species are left behind, that's known as oxidative stress. That's good in small amounts, because that will kill other things around it. Assuming that this guy got overwhelmed when he dies. Maybe other cells are being overwhelmed, and then that oxidative stress will kill it. Yep. This is known as a reactive oxygen species or reactive nitrogen species. But when that goes on for a long time, that's what actually causes chronic disease, like heart disease, cancer, aging, this is actually why we age, reactive oxygen species, autoimmune disease, dementia and obesity. Nobody ever thought that you can become fat because you have low level chronic inflammation. And I've talked about this on other episodes. 22:56 Definitely.22:57 So final step here is the thing you didn't know about, which is the toll like receptors, right? Okay, so toll like receptors is just another layer of defense, where if these toll like receptors are actually activated, they do very specific things. For instance, the toll like receptor number seven, is very specific to release certain things to fight RNA viruses. You can go through these others, there are ones that are built to fight bacteria that are flageolets flageolets. Yeah, I think we're both saying that wrong, but that's okay. fragilities, flageilities. And they also do something that we have talked about before, I want to say we talked about it. On at least three episodes, I can think of the epigenetic phenomenon of nuclear factor Kappa beta NFKB. So when the toll like receptors turned on NFKB goes up. And NFKB is the one that we talked about with the broccoli episode, right? with David Roberts and john gilday. On Yeah, this is the one that actually has a what's called plio trophic phenomenon. So it affects many different things. So when NF Kappa beta is turned on, then you go through a huge surge of our old friends, TNF alpha, interleukin six, right? So he has more inflammation with inflammation, the common theme of inflammation, right? So inflammation, what does inflammation lead to? Oh, this dementia, autoimmune aging, cancer, heart attack na, so this innate immune system is here. The other thing that I did not mention was that when the toll like receptors get turned on, like this toll like receptor number seven, which is for viruses, one of the things that releases is interferons. interferons, actually, are molecules that directly destroy cells that have been infected with viruses. So if you were to get a virus, you breathe it in through your nose, let's say it goes to your lungs, a cell is being attacked, it can actually send a signal to a healthy cell says We're under attack, you need to be ready for this. And that's the little cell that waits with a gun at the door. So when the virus rings, the doorbell goes and shoots it. That's not proper technique and how you shoot it. We've25:21 seen actual footage of this going down at a microscopic level. So yeah,25:24 it's it's fascinating. Yeah, absolutely. It's like watching an old Western, just like oh, my gosh, and the. And it's totally true. Because the viruses that show up, they always wear black hats every time every time. Yeah. So that's a recap of very quick recap of what we talked about last episode. Yeah, I get it a little bit more detail. How's it? How's the sound quality?25:47 The sound is much better than last time.25:49 Okay, good. So hopefully, we'll continue with this. So how do we describe how functional foods work? Because our big thing last time was improve your immune system do this, but nobody talks about how, why?26:05 I've got a question for you. So when we look at this, and I think this is a reasonable question, you look at it, and we're talking about all the bad manifestations that happen. When there's too much TNF alpha, or aisle six or aisle one, we have too much row s, or I'm sorry, reactive oxygenation, species, ultimately, too much inflammation. But I needed all of this to happen. So, Dr. Brown, what is it that I'm missing? That would help me not have the system that I need? That keeps me alive and safe, run out of control? And basically, ultimately destroy me anyhow?26:42 Absolutely. So what we're talking about is how do you optimize? Yeah, well, running immune system. Definitely. One of the theories right now is that why do younger people not get sick with the current virus that's going around, is because they have a very good innate immune system. As we age, as I mentioned, as we age or you become sedentary, possibly, this happens. And so you go, Oh, well, I still don't get that. We'll imagine this. Imagine quietly, this attack happens, virus, bacteria, anything, and your innate immune system is kind of slow to react. And by the time it realizes, Oh, my gosh, something's going on. Many cells have been infected. Which means when these cytokines go up, it's a huge amount. If you have a really healthy innate immune system, you catch it at the first cell. Yep. So let's talk about functional foods. functional foods, functional foods, polyphenols, so I'm going to use these little brand. These little hexagons. Yeah. Demonstrate functional six added. Yes. Excited. Whatever you go.27:50 All right. Now hexagon, you're27:52 right. This is all based off of science. All based off of very detailed documented, I want to thank every PhD out there who goes through this kind of trouble and probably gets no recognition. Because this is Sony. And, you know, we're talking about so when Dr. Mark Gordon was on his show today, he didn't really understand why course it's an or why tumeric does this. Let's talk about that. Let's do that. All right, step one. So this will represent the different stages that it actually happens. Step one, intestinal gut health, intestinal gut health, that's your first barrier. Anything that comes in, you're going to make sure that you have a good healthy working gut, healthy work in gut. Step two. We know that it has potent antiviral activity. I mentioned earlier in the other article about how these functional foods can actually destroy viruses on contact.28:52 So we've got gut and the virus itself.28:54 antivirus itself step. If the virus makes it past that, inside the cell itself, is the M protease that allows the virus but bacteria do this also. It has to attach to the cell. Well, what does it do? It prevents it from attaching then, oh my gosh, this is a really tough virus and it made it through all these lines of defense already. Yeah. Well, as it turns out, bunch of foods polyphenols actually work zinc Ionafores and prevent the replication29:35 Hmm. Blocking replicase 29:37 replicase correct. Nice actually blocks the replication.29:42 So So right now we have four tags up and we're still on number one of the innate immune system. That's29:47 why it's so important to understand the innate immune system. Yes. And why nobody's talking about this. I'm going to keep going. Yeah, and this is not once again, this is not my opinion. Yeah. We've got 1000 articles to To show all of it, right? Okay, so now we got our friend, the mast cell over here and everything that I'm saying is not an on or off switch, it's the optimized way to do it. If your body needs it, these functional foods help it ramp it up. If it doesn't, it does it. Alright, so the mast cell that releases the braided cinans that go to the blood vessel, oh, the mast cell actually gets stabilized by functional foods, polyphenols, nice. So it doesn't overreact or under react, then it's almost like, really, truly Mother Nature's secret weapon, then the blood vessels which release the fluids, there's something called or I forgot what the actual enzyme is, but it actually attenuates the enzyme that creates the leakage. So it controls the amount of fluid that comes out. And in the same line, what it does is it actually controls the amount of the adhesion molecules, so all those little hooks that grab that, right, it actually does the optimum amount for that. Okay. So getting back, this is why Dr. Mark Gordon was like, Oh, we have shown that it helps with inflammation, I'm going to tell you exactly where it helps, right whole pathway. Okay, so we've now blocked the little adhesion molecules so that only the right amount of cells come out, only the right amount of cells come out. And remember, when I said that it monocytes become our antigen presenting cells, it helps them mature. Oh, it's like steroids for those guys.31:35 So it activates them. It's a growth hormone, right? So we're allowing these phagocytes to now do their role. And by having the right amount of polyphenols available, it's going to do it quicker.31:45 Exactly. So we're now heading to step two. So what does it do? Oh, yeah. It helps the antigen presenting cells, taking the vacuoles and put those different proteins on the outside quicker, because it's already made these more mature. And then we get to the real important part, it tells the antigen presenting cell, yo, be a little careful how many cytokines you send out. Hmm. So there's multiple studies looking at each one of these. And so I'll do this real quick. While you're32:19 putting those up there, I'll just add that Dr. Gordon spoke today specifically about how high circulating cytokines lead to insomnia and an inability to rest enough because it causes neural inflammation, which is just building on it. That's32:33 right. He did, he talked to specifically about that. And that's that brain gut connection and percent inflammation, that's what we always talk about. So as it turns out, it tells the antigen presenting cell, Hey, be careful what you do, then just to make sure as another safeguard, it specifically will control how much TNF alpha, how much interleukin six, how much interleukin one and how much interleukin eight is actually necessary. And these are all documented on specific studies. And I know that these are being done in humans right now, because I'm getting preliminary results. And they're showing very specific in vivo, meaning people that have this kind of situation, actually decrease these different cytokines. So it's not just a total decrease. It's the right amount. So if you need more white blood cells, then there's no reason to shut it off completely. Right. Like we just can't You can't be smarter than Mother Nature. Yeah, comes down to Okay, how am I sounding sound good. All right. Now, let's go to it's a lot better than last week. So so let's go to Step three, the antigen presenting cells that do this, also do another job, briefly, which we will get into in some other episode, or will bring a better person to do it. Some of those cells go to the lymph system, where they then activate the adaptive immune system where they form antibodies.33:56 Very, very important,33:58 relevant right now, because if everybody's running out getting a vaccine, that's what you're working on worthless unless you have this optimal.34:04 Yeah. 100%.34:06 So we won't get into that. But guess what functional foods polyphenols do?34:10 Oh, you don't even tell me that. They also work on that side. They also work on that. It's almost like your body wants polyphenols.34:16 It's almost like your body wants polyphenols. And of course, while we're at it, I mean, it's like it's almost like no, no, now he's just going overboard. No, no, I mean, it's, trust me, I read every article. It's like I feel like I'm making stuff up. Now. It helps produce interferons. It helps control the toll like receptors.34:43 So means you're just a side note. interferon if anybody's ever dealt with early stage, melanoma, I mean, there are various cancers that you actually had to end up getting injections for interferon.34:54 I did I really thought you're gonna go if anybody's ever dealt with herpes. Now I'm dead serious. Yeah, like Libya isn't interferon?35:02 Absolutely. It isn't interferon. I'm just saying I guess what I was going is, is that35:07 if you've ever dealt with herpes, you kind of looked at me like, no.35:11 That's how I felt.35:16 But this is true. So drugs do this. You're exactly right. chemo drugs and drugs like a cycle of beer. They're their interferons. Yeah, because they block viruses. So polyphenols help increase the amount of interference when it's necessary. Correct. And by blocking the toll like receptors and controlling that. They actually decrease nuclear factor Kappa beta nfkb. We had that talk with Brocelite. So polyphenols and sulforaphane block, NF Kappa beta. So35:46 I was making sure that you're making contact with the people in the room. Do you think I was I was waving over somewhere else?35:52 I thought you were having a hallucination. So all right, so we blocked NF Kappa beta, which ultimately we know does the most major thing inflammation. So we've been saying a long time that the Mediterranean diet is an anti aging, anti inflammatory diet. Yes. This is why when Adele did her sert diet, this is why it works. You decrease overall inflammation, definitely the whole process. And because, oh, I skipped a little step here. But one thing that we always talk about is the potent antioxidant effects.36:33 Yeah, I'm glad you're getting this part because we're going to augment this little section here, too.36:37 Yeah. So tell me what you got to say about antioxidant.36:39 What is it immediately takes me back because ROS is something that Joe botel and we've referenced her on the show multiple times. But when she was talking specifically about long endurance athletes and how they get injury, and how certain people who are high performance athletes get injured and have a difficult time recovering, it's often because they don't have good control of their RMS or reactive oxygenation species. you're pointing at something, but I'm not on camera. Oh, I am now. So there we go. I didn't know that. There's no red lights in here, by the way. But I find that to be a really big key aspect about rlms. And what polyphenols do because she specifically said to it to decrease healing time and increase optimal athletic performance, high polyphenol concentration, or normal amount is a must, and that our bodies are simply waiting on enough polyphenols to do this job.37:34 Yes. 100%. So now the final part here is more of a vague, you get a picture camera now to fix the camera. You can't take me by surprise anymore. I mean, we can hire Mike to find our to find our podcast sponsors, but we can't even hire a good audio visual guy.37:50 I don't think that hot dog company comes with that.37:56 Alright, so we get down to this last thing here, which is chronic disease. So what we talked about low level inflammation. This is how you can protect yourself against heart disease, cancer, aging, autoimmune dementia and obesity. And I put this one up as a general one, because we mentioned it a little bit, I want to talk about it right after this, about how large stable polyphenols I found an article that showed the more hydroxyl bonds on the outside, more beneficial is. That's why when we initially were developing Atrantil, and Dr. Bruce Burnett looked at this and said you picked the perfect poly phenol to be the most bioactive and most diverse.38:37 That's all he does. There's there's more points to do stuff. It's like more surfaces. It's more38:41 surface area. Exactly. And then in addition to that, we know that in all these articles, so if you're somebody you're like, Oh, I already take tumeric. I already take quercetin and that's awesome. Keep doing that. Yeah, keep doing that. But you have to understand something tumeric and quercetin don't get directly absorbed, they actually have to go to the microbiome where they get broken down into the metabolites. I've got articles to show what is the effective metabolite, of quercetin. So when Dr. Mark was talking about that, I want to tell him, that's awesome. But you better make sure that you have a good microbiome. So what this represents is the prebiotic ability of polyphenols to diversify your microbiome so that when you take these things, you're getting the appropriate we're gonna call them the appropriate metabolites. I call them post biotics, but we're gonna call him the appropriate metabolite.39:31 It's a honestly it's kind of like if, if you look at the way that he talked about ecgc, and, and tumeric, and trying to enforce it and etc. He broke all those down and talked about their beneficial natures as it pertains to inflammation. But what you're describing, if I can kind of put it into layman's terms, it's almost as if that is great. And you can get an Uber to have that delivered to somewhere and you hope it's a great car and you hope It gets you there comfortably. But in order for it to be effective and get there on time you want a private car you want the limousine. The limousine is the larger molecule, the all natural, larger parent molecule, if you will, kind of like what's in Atrantil and abbraccio to do that,40:17 exactly. So what you want to be able to do and what we're saying is not just supplements. Now, this is why you want to have a very colorful plate. That's why you want to have lots of fruits and vegetables. Yeah, continue to do that. Try to do every non GMO foods and vegetables. But when we're talking about polyphenols, very few things concentrate polyphenols, so when you're like, Oh, I heard Dr. Oz talked about reservatrol polyphenol. Oh, I heard someone so talk about Kirsten, polyphenol. Oh, but you know what? I drink green tea, polyphenol. Yeah. And they all get broken down. Here's what's fascinating. And I can't wait to do this. When we have Dr. Sylvia on her research is showing that you can produce quercetin egcg, which is green tea extract. You can produce the metabolites of curcumin and all these things from larger tannins. Yeah, that's what I mean, this is so fascinating, and your body knows how to do it. And you know what? I mean? Do me a favor, when you get done watching this, go to COVID? episode number two, because we did that in March. Yeah. And we were right, because we talked to scientists all the time. We're always doing this. So Sofia said, You know what, I'm gonna challenge you not to we will share the mic even though the You and I both been tested, like yesterday. Yeah, for COVID and we're negative, can you walk through and just explain what each one of these days does really quick, 41:30 I'm going to try Okay, so that a right there is going to prevent the virus itself that a if there's for the gut microbiome, that a I believe is going to prevent it from binding to that set of cells, that one is going to function as a zincionafor prevent or allowing zinc to go in and stop the replicates that is a mast cell that's going to help control the number of goodness gracious, I guess those little inflammatory markers that are going to go to the blood vessel braided cinans kind of There you go, and then be circulated which of course, we're going to regulate the amount of fluid that's going to leave the bloodstream and we're going to stop the amount of flags are gonna pop up as appropriate. Orders one, Oh, that one is a phagocytes, that's going to improve the the maturation of the phagocytes the one just below it is going to help the phagocytes since they are maturing more quickly, it's going to allow the them to display quicker and then it's going to regulate the number of cytokines which is TNF alpha, IL six, IL one and il eight. And I don't know if I'm gonna go through the mechanisms of those but that's okay. Oh, yeah, good, quick. TNF. Alpha is for the brain. IL six is for the bone and it's because of white blood cell maturation IL one is for infection and inflammatory things that come from the liver and i l eight, is what is going to basically start the cycle all over again, where the fluid is, is being summoned and redness, swelling and pain.42:55 Excellent. Stage three.42:56 Okay, that's the presenting. Yeah, it is. And that's where the cells dying, we get to oxygen a oxidative stress. Yeah, it says that. But we need to control our ros because it's not the RO S is bad. Too much ros, though, can lead to long term heart disease, cancer, aging, autoimmune dementia, obesity, and adaptive antibodies, we aren't going to go all the way through there. But essentially, aside from the innate immune system, we need help in the adaptive immune system as well.43:28 It would be fascinating to see what the antibody levels of people that are vaccinated if you're scientists out there on your on your cool study will supply you with some big polyphenols and see if people mount a better antibody response. If it lasts longer. These are all just fascinating questions. What's this?43:45 So when we get over here to TLR, we this is what is going to function as another flag zone, where we're going to signal the liver to then produce interferon, which functions to fight cancers and all kinds of different things like that. And then we have NF kb. We've talked about this extensively, whenever we had Brock elite on the show, both john and David was gonna say, Robert, but it's David Roberts on the show. And essentially, what we want to do is not have this gigantic burst of TNF alpha, and IL six because it's just going to turn into more inflammation. And again, Polly finos once again, aren't going to abandon you. They're still going to work even on that end. Okay.44:32 You're so much smarter than I thought you were. Nice job.44:36 I just remember a lot.44:38 Can you hear me on this one?44:39 Yeah, yeah, that was never good.44:41 You can probably take the headphones off now to show everybody. So did that make sense? I44:47 think it makes a lot of sense. I mean, it's a lot of information. Not everybody is going to just readily walk away, like we just did from it, but watch it several times. I think though, really what we're trying to show here is that We don't want to just say that we don't want to just say that polyphenols they'll work with with viral or bacterial infection. This is something that I wish more people would do you tell me that something works. Just explain how show me how how do you know that it's going to work? And I'm not saying that people don't have markers or blood enzymes or circulating things that they measure, they see things go down. That's important that lets you know that we're on the right track. But this kind of stuff, this kind of research that you've been sifting through with Angie, is just awesome. Because now it's almost like putting a name to the face. We can see how it's working. Exactly. So I think it's important. 45:41 And this doesn't just stop here because you know, Angie's episode, people, it's really being shared a lot. Oh, yeah, just people if you have pots or Ehlers danlos or CBOE or anything, people thousands of downloads on the podcast, by the way. Yeah. And she describes how when you have NF Kappa beta up, yeah, you're gonna have decreased acetylcholine when TNF alpha like this is all the balance in that. Yeah. The key is to see the colon whenever Yeah, but that's a whole separate conversation. This is strictly on the innate immune system, right. And so I find it fascinating. I find it fascinating that when I listen to another doctor talk about this, and I'm like that I very much like, very much like me, like, I'll listen to stuff and the patients will ask me, they're like, hey, do you know about this? And I'm like, I don't have the bandwidth and the time to do it. That's awesome, which is why I kind of tasked or I didn't task. She did it on her own, which is why Angie learned so much about dysautonomia, like I just don't have that in me right now or the time to do it. And she crushed it. Yeah. And one of the what we've been emailing, she's been emailed by so many people, she's gonna keep going, she's gonna end up writing a book and probably saving a lot of people. And so this is this is first step, innate immune system. I tell all my patients, let's exercise a little I don't care what you do, just get up off the couch and move around, right? Doesn't really matter what, don't eat highly processed foods, like high fructose corn syrup, soybean oil, anything, you're open in a package, read the label, because that breaks down that Mary, Mary Mary first step, which is gut health. All health begins and ends in the gut, definitely. And then get your polyphenols, get a little sun, get some sleep. Do you do that? That's better than what's better than most are doing.47:32 I mean, it really is. And it's, it seems complicated. And but in the end, the actionable items really aren't that complicated.47:41 I mean, when we're in some weird times, I mean, let's be honest, we're taping this episode. The day after we had that weird thing that happened last night or yesterday where47:51 you didn't get your change back at the store. I didn't47:53 get my change back. I'm still upset about that. The lady was clearly distracted, because apparently our government was overrun by48:02 Oh, yeah, that was a big deal. Yeah.48:05 And so these are stressful times. Yeah, we got to keep the inflammation down. There's nothing to cause inflammation. Yeah, don't, don't bring it upon yourself. Don't eat bad. Don't lose sleep, and make sure that you get your polyphenols.48:17 To my knowledge, polyphenols won't directly help bad politics, but maybe those politicians could use some more polyphenols and they wouldn't act so crazy.48:26 Oh my gosh, don't even get me started. Because what I want to do, and I believe that this will be the future we're gonna be sitting here 50 years from now we're gonna look the same because of the anti aging qualities of polyphenols. The 50 years from now we're gonna be like, wasn't that great that they put psilocybin in the water so that we all treat each other nice. You know? It's so you're just gonna pull up instead of Starbucks, you're gonna pull up to MDMA cafes? And I'm not kidding. Like the research on that is like, we're gonna go there also. Yeah, there. Somebody joined at baby bathwater Dr. Raven, I was reading his profile, really cool. And we're gonna I'm gonna try to bring him on here. But he's got a device called an Apollo device, which vibrates when you're not breathing appropriately, which means if and we're gonna do a whole episode on breath work, and we got our we just got all kinds of cool stuff to do. But you can't, you can't leave this hanging like, this is important. Look at all those. Look at all those one last time here. Let's just look at the amount of places.49:29 Places I'm just counting right now. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 19 20 looks like there's almost 20 things out there49:40 that I found in a guy like Bruce Burnett, sitting at home, he's like, there's 38 you're missing the critical ones. 38 on line one. I know. Well, this is this is what you get when you let a doctor try and try and try and describe this.49:54 Yeah, but seriously, I think the takeaway here is that we can put there's no Muscle behind the message there, it really does work. And this is not specific to any one virus or any one bacteria. This is what your body needs in order for your immune system to work efficiently just so happens, that it works really, really well for what a lot of people are concerned about.50:18 It does and you just came up with a whole new idea. But as we close this out I think I'm gonna attach this next time I do a hemorrhoid on a patient so we can hear50:27 the hemorrhoid. Be sure that requires some type of consent. But yeah, I think it's awesome.50:34 All right. So thank you, everyone, for listening to this. I hope that this is something that makes some sense, please share it, subscribe to the YouTube channel. Subscribe to the I guess all the other platforms, iTunes and Spotify and 50:52 we are honestly the run on Atrantil at the KBMD store has been kind of intense over the last two months. So number one, thanks for everyone for sharing all the information here recently we're doing all that we can to bring that part back online but we'll have an associated discount probably with this particular show. Just in general with with the immune system. Yeah, and as soon as that rolls out, then we'll make that available and all the show notes etc.51:15 Totally and thank you diarrhea dogs for this episode go to diarrhea dogs.com put in code Mike for a 98% discount.51:26 I can't wait to find out what people email in and say what's it diarrhea dogs.com.51:33 Remember, it's code Mike, for 98% discount.51:39 I think it's probably gonna do it for us. Thank you all for joining us on the gut check project please like and share and we will see y'all with 48 with some continuation on the immune system. Talk to you then51:49 bye bye. Thank you.

Season 2 Episode 3: Part 3 w/ Dr. James A Ankrum

Me Before Mom

Play Episode Listen Later Dec 1, 2020 58:40

Associate Professor of Biomedical Engineering at the University of Iowa, and brother-in-law to Bert, Dr. James A. Ankrum is back for the third and final interview on COVID-19 and coronavirus. In this week’s episode Dr. Ankrum is discussing the second (or third) wave of the virus, what we really need to understand about holiday gathering with its risks and the potential vaccines on the horizon in 2021.From this Episode:Dr. James A Ankrum, University of Iowa, Mendeley.com publications, Google Scholar publicationsstatnews.comBill Nye the Science Guy doing the mask test91-divoc.comWorld Health Organization COVID-19 informationMatriarch Digital Media produces this and other podcasts that understand, encourage and uplift women.

Season 2 Episode 2: Part 2 w/ Dr. James A Ankrum

Me Before Mom

Play Episode Listen Later Nov 17, 2020 35:28

Associate Professor of Biomedical Engineering at the University of Iowa, and brother-in-law to Bert, Dr. James A. Ankrum is back for more on COVID-19 and coronavirus. In this week’s episode Dr. Ankrum is breaking down masks, how to understand the models and charts, coronavirus testing, and transmission in kids and schools.From this Episode:Dr. James A Ankrum, University of Iowa, Mendeley.com publications, Google Scholar publicationsstatnews.comBill Nye the Science Guy doing the mask test91-divoc.comWorld Health Organization COVID-19 informationMatriarch Digital Media produces this and other podcasts that understand, encourage and uplift women.

Season 2 Episode 1: Part 1 w/ Dr. James A Ankrum

Me Before Mom

Play Episode Listen Later Nov 12, 2020 38:56

Associate Professor of Biomedical Engineering at the University of Iowa, and brother-in-law to Bert, Dr. James A. Ankrum is breaking down the science surrounding COVID-19 and coronavirus. Dr. Ankrum is explaining how to understand the information about vaccines, how clinical trials are performed, and the safety of vaccines being developed. Bert learns about Operation Warp Speed happening at the FDA, and the national security surrounding a stockpile of chicken eggs.For more information, check out Bert's website: https://bertmanderson.comFrom this Episode:Dr. James A Ankrum, University of Iowa, Mendeley.com publications, Google Scholar publicationsstatnews.comNational Library of Medicine pubmed.govFDA Operation Warp SpeedMatriarch Digital Media produces this and other podcasts that understand, encourage and uplift women.

High Fructose Corn Syrup: Avoiding It Can Save Your Life

workouts gymshark workout programs mendeley

Play Episode Listen Later Oct 22, 2020 47:11

Eric Rieger 0:00 All right, we are here at gut check project. Welcome KBMD health fans and family. We are on location in Conroe, Texas at Southern star brewery with my co host, Dr. Kenneth Brown. I'm Eric Rieger Dr. Brown. It's Episode 42. And this does not look like our set.Ken Brown 0:19 This is not our set. And this is very special. First of all, shout out to Southern Star Brewery, or letting us do this. Now we're here for a reason, a very special reason we are. This is going to be a really cool episode where we're going to talk about something really important and how it impacts the health and the future of everyone living in the United States. We're gonna talk about high fructose corn syrup. And there's a reason for that, because the next episode, oh, man, Eric Rieger 0:42 It's huge if we won't give it all away. But if you're tuning in for this episode, you're missing out. If you're not watching the one that comes right after this, we've got a special guest. And it's the whole reason that we're here in Conroe, Texas, Southern Star brewery just north of Houston, you can hear the sound in the background, the music's going crazy, but it's all worth it.Ken Brown 1:01 And the really cool thing is Southern Star Brewery, I just spoke with their brew masters, they do not use high fructose corn syrup. So we are in a perfect place to do that Eric Rieger 1:09 We are in a perfect place to do this. So Dr. Brown this particular episode, we're going to really get down to the meat and potatoes we normally don't do, quote unquote short episodes, even though we try to do that. But today, we have a topic that we really kind of discussed that we needed to cover before we had our special guest on. And this is an election cycle also. So of course, the next guest the next episode is definitely I would say political when you say it is definitely political, but also like minded, very like minded and really much very interested in your health. So let's get straight to it. high fructose corn syrup. That's what's on the table today. Why don't you kind of steer us where we're gonna go.Ken Brown 1:52 So we were planning on doing high fructose corn syrup, regardless. And then yesterday, a patient of mine sent me an article said, Hey, check this out. And an article just got published out of the University of Colorado, okay, where they looked at the lows. Yeah. And they, they were able to associate that symptoms, ADHD, aggressive behavior, and bipolar disease can actually be linked to high fructose corn syrup, not just Oh, if you drink this, this happens, scientists figured out that the reason why is that when you take in high fructose corn syrup, you are actually starving your brain. Your brain thinks it's starving, while your body's getting fat. And so because of that, your brain goes into what is called a foraging mode. It actually turns on remember when we talked about orexin and things like that when when you go into a forest? Yeah, guess what your brain is going Yo, we got to get some food here. Even though you're drinking mountain dews. And you're opening up, you know hohos and stuff and you are morbidly obese on the outside, your brain is starving for energy. And they're attributing that this could actually be the the reason why you have hyperactivity, creating ADHD, aggressive behavior, and bipolar disease. When you have foraging mentality, your brain tells you to go out and do something. So you end up with impulsivity, aggressiveness, and reactiveness. And I just want, there's no way a patient just sent me this article. It came out yesterday. And we were already planning on talking about this beautiful timing. So this is just one article. I mean, that just showed up yesterday. So that is, if you are interested in high fructose corn syrup, and you happen to be somebody who suffers from anxiety, ADHD, or impulsivity, listen,Eric Rieger 3:41 well, another thing to take away here is where do you find high fructose corn syrup? Oh, I don't know, almost everything that's processed with sodas, breads, treats. It is a sweetener, per se. And a lot of people have even told me I remember when I was younger, that it was just like sugar. Well, it's sweet. And that's pretty much where it ends. We've already talked about the dangers of just even sugar exposure. Believe it or not, it's worse. It's truly worse. We're gonna get into it today, but Coke's, Pepsi's sodas, if they're sweetened. And I mentioned breads and treats. But in sometimes you'll find high fructose corn syrup and things that you don't even perceive as sweet. Which is the problem Ken Brown 4:23 100% we're gonna get into that. Now, one of the things we do here on the gut check project is we want to bridge the gap. A lot of people always say, Oh, yeah, I've heard the same on high fructose corn syrup. And in this climate right now, it feels like everything could be politicized. Yes. And I feel like even bringing this up could turn into some sort of political argument. That's not what we do here. We're just gonna talk science. Let's, let's talk objective data. So I'm gonna throw this at you. You're better at the historical aspects of things. Let's just briefly go over how did we end up with high fructose corn syrup in everything.Eric Rieger 4:57 I think if I recall the story, somebody What correctly, we needed number one to have sugar or sweeteners available, we wanted to see if we we mass produced products that the shelf life could be extended. And in doing so we also had farmers that had grown a lot of corn. And so you have the I think it's the Corn Growers Association or corn refiners Association, CRA that essentially functions as a lobbying agency for corn growers. And what they found is they could compete in the sweeteners market by mass producing high fructose corn syrup. And this process was, I don't know if it was discovered accidentally or on purpose. But ultimately, it's a two step process, which one phase of it is somewhat, I guess, naturally occurring if you force it, but it's not a natural thing to have.Ken Brown 5:52 It sounds like you're describing a Labradoodle?Eric Rieger 5:54 sorta a Labradoodle of sugar.Ken Brown 6:00 Kind of natural, but it was forced. Yeah.Eric Rieger 6:02 It's kind of like a liger. You're not supposed to have them.Ken Brown 6:08 Did you ever see Dan Cummings? Chocolate squirrel doodle?Eric Rieger 6:13 Oh, the comedian.Ken Brown 6:15 He does a whole set on this exact topic. Yeah, mixing animals that shouldn't be missed. Anyways, off topic already, wow, are are super fast episode. on time, DeRay. A lot of the time. Everything you're saying is true. Let's just put a little historical context into it. So basically, since the 1920s, there have been farm subsidies. So the US government has said, okay, we need to help out. We've got a great depression going on, let's make sure we have enough food for everybody. And then, through a series of events, which I'm not an economist, but basically the 1960s. During the Nixon administration, there was a series of events like a couple bad harvest years, and then we made a bad decision to sell millions of tons of grains to the Soviet Union. And all of a sudden, we ended up with a shortage. This shortage, of course, led to the overcorrection, which happens in government at the federal level a lot. It's like driving down an icy road, you turn a little bit here and go well, and then you overcorrect and now you're spinning out of control. Yeah. So in the 1960s, they started this subsidies program where they were going to subsidize farmers and ultimately, the most abundant crops were wheat, corn and soy. Okay. So then this was started, because through a lot of different reasons, those were the ones that were subsidized the most. And then in 1996, it was discovered, oh, we've way over corrected, we've got way too much of this stuff. So the federal government put in new mandates, which then said, Okay, we're not going to subsidize this anymore. But since we were doing it for so long, everybody that was subsidized gets grandfathered in, at the rate that we've been doing. And since the major crops were corn, wheat and soybean, they got subsidized. And they were grandfathered in whether or not they grew, the crops paid did not grow anything Hey, did not grow. And guess who wasn't getting paid at all. The farmers that were growing fruits and vegetables, they got squeezed out immediately. So, so now you've got these farmers that are being paid with our tax dollars to make more of a grain that we don't even know what to do it.Eric Rieger 8:20 I know we're gonna get into it. But you're telling me that essentially, we have a food additive that is being subsidized. So now it's already somewhat less expensive for not only a producer of foods, but even the consumer to get its hands on now. Right? So we've reducing the threshold of normal people to get their hands on the substance. Surely, since we weren't doing that with fruits and vegetables, it must be better for us, right?Ken Brown 8:47 So what happened was, we have all this corn. And some Japanese scientists in the late 90s figured out that when you add a couple chemicals, natural enzymatic chemicals, you produce this high fructose corn syrup, since we're already subsidizing it. And it's really easy to make, then it's 70% cheaper than standard sugar cane or standard cane sugar. So automatically, you've got a 70% advantage. So then they realized oh my gosh, it's also two times as sweet as sugar. And look, it works as a food preservative. We just found the holy grail of the food industry. So it just exploded. And in fact, since then, or since it was discovered how to make high fructose corn syrup 1,000% increase in our consumption has taken place. It's ridiculous thousand percent. So our ancestors would normally take in. I don't remember the exact numbers let's but I think it's somewhere around 20 grams of sugar in a year.Eric Rieger 9:53 Now we're in a bit just just to categorize that's not including just fruits and stuff. You're talking about just raw sugar and and another Think just for context, today's standard is just try to consume less than 22 grams of sugar a day aKen Brown 10:08 day. So in other words, right now, without even trying, most of us are consuming what our ancestors did in a year, in a day. So you said, Surely it must be better for us. It's not and quit calling me surely I don't know how many times we've talked aboutEric Rieger 10:25 airplane.Ken Brown 10:28 Alright, so real briefly, we're gonna get a little sciency, then we're gonna do a quick deep dive and then come right back out. So just hang in there. But the whole point of this is we don't want to make it political. But it is impossible to not discuss some of the political aspects of it, because it's because of the subsidies that we're here on. Let's be clear, and if you identify as either right or left, believe me, both sides are involved. This is not exonerated either side whatsoever. All right. So why do you even care about fruit dose? Well, glucose, which is the sugar that we always talk about, right? table sugar is sucrose and glucose combined, and then all of a sudden we start throwing then it's fructose right about now a bunch of people are just going that's too many else's, like I agree with you. So let's focus on the one else. fructose. fructose is the only sugar which is metabolized in the liver, it does not need insulin to drive it into the cell. Glucose is used by every cell in your body, fructose goes straight to the liver, right. And it's when it goes to the liver, that it has to be broken down and then metabolized. That doesn't happen with that. So we've got this very cheap sugar that is metabolized in an unnatural way, right. And it's not used for energy. And we're going to come full circle here. But basically, we now know that fructose consumption has epidemiologically been connected directly to the diabesity epidemic that we have. And now I can tell you in a little bit on a cellular level, how it actually does that. But we've already mentioned that you said it lasts longer. So if you're going to go out, and you've got a granola bar or an apple, and you go Oh, the granola bar is healthy. That's nature made set it is that commercial showed hikers there and sure the commercial doesn't show somebody pulling an apple out of the backpack because an Apple has a shelf life, right? The granola bar can sit there forever, and it sits forever because they hide the sugars in it. Right? You don't even think of that now. And then we talk about other foods that are there. So when we're sitting there taking this for people that are like, Oh, I like this food better. I like this bread better. I don't know if you saw that, that an Ireland, they they won't allow subway to call in a sandwich. They can't call it.Eric Rieger 12:37 I don't think they can call it aKen Brown 12:38 brandy. They can't call it a bread because the sugar content is five times higher than what bread should be.Eric Rieger 12:43 Yeah. I mean, that's that's alarming. Like, it's not like, Oh, I can't believe they don't let us call us bread. Well, they can't call it bread because it's not bread. Yeah.Ken Brown 12:51 Um, the interesting thing is that it is actually extremely addictive because it is two times sweeter than sugar. So you condition your body to watch that sweetness. Sure. And then we can get into exactly why all this is going on. The irony of it all is that actually makes people hungry right? Now I just told you about an article where you have ADHD because your brain cells are starving. Sure. Now, we know that when you take this, what does that mean? Tell me one benefit, other than it's cheap, and you can sell more products, but you get no nutritional value out of it. And you actually cause damage as you take it. Like it's like if you start with that they wouldn't allow it to be made ever.Eric Rieger 13:34 I mean, quite honestly, it sounds to me like every advantage is somewhat sinister. It's it's there is no advantage about this. There's not a direct advantage that I'm aware of, for the person that's consuming it. And I think that's that's really what we need to be concerned about. Because we're consumers weKen Brown 13:51 Yeah, we do. And fortunately, we're consumers that are doing a podcast that a microbrewery that uses all natural ingredients, and they're very conscious about not doing that. We're consumers that are in the health field. Correct. And unfortunately, the burden of diabetes high blood pressure and death in the poorer socio economic areas is much higher than the general population. Yes. And then when you start reading about it, they consume they being people in poor social economic neighborhoods and in cities, they may not have access, they may not have the money nor access for healthy foods. I don't mean healthy. I mean just something that isn't fast food or in a packageEric Rieger 14:35 right and most fast food is going to be made with high fructose corn syrup and other additives don't don't get me wrong. There's others out there. It's not by itself, but we're talking specifically about high fructose corn syrup today. And you're you're correct. The subsidy has made it to where that's what is obtainable. That's what they can eat because it's cheaper for the producers to Make it because it's a subsidized product because it serves as commodity. It doesn't make sense. We are making it easier for taxpayers to subsidize people who don't have money to get sick and stay sick. And they have this anxiety. It's a horrific cycle. Because if they're trying to climb out of poverty, guess what? They don't feel normal. They're not thinking, like they should beKen Brown 15:21 that article that discuss the impulsivity. Yeah, that really got me thinking, right? I mean, we always blame we try and blame so many things on different aspects. Oh, we're obese because we're not getting enough exercise. And I can get into a whole different aspect of this where the Corn Growers Association hired scientists to put out public statements that basically said, high fructose corn syrup is really good for you. You're just not working out enough.Eric Rieger 15:49 Yeah, it's ridiculous.Ken Brown 15:50 And then we're looking at this, you're like, wait a minute, areas that have the highest burden of obesity, and have high blood pressure and diabetes, which lead to this huge cost burden in the United States have the highest consumption of high fructose corn syrup. Yet, there's people out there saying, Oh, it's not related. They're just not getting out there jogging enough. Now, that is, I'm going to give you cellular reasons why this is wrong. But if you don't care about it, and I know that we're going to talk some politics on the next episode, if you look at the pure numbers, since high fructose corn syrup came on the market, Eric Rieger 16:26 right. Ken Brown 16:27 And we're taking 1000 times more than we used to, it is estimated that right now, 60% of the adult population is overweight. The prevalence of insulin dependent type two diabetes, that means diabetes that didn't respond to medications, and you eventually have to go to insulin is 9.3% of the population. Pre diabetics is through the roof, they're estimated that about 30% of the US population right now is pre diabetic. It's sad. 60%. It's, it's sad. It's also really expensive. Yeah, I'm gonna put you on the spot. How much do you think the burden of this cost the US annually? Thank you for putting me on the spot. And I will say eleventy billion dollars, because I don't know the number that is very close to 327 billion, because it's, it's encompassing the health care costs of this, that's ridiculous. If we could fix one thing if we could fix obesity and diabetes. Sure, if you take out diabetes, just the causes, just the morbidity of obesity Sure, is like 192 billion. And if you look at diabetes, 327 billion, that includes loss of work when people get sick, and you know, all the other weird numbers they put in there. 320. Okay, so imagine if we could sit there and get roughly 527 billion off the tax records off of our tax burden. And all we got to do is take one food subsidies. So we're paying taxes that are now going and making peopleEric Rieger 17:56 sicker. And it's by it's by design, if you just step back and look atKen Brown 18:00 and then right now in 2021 of the hottest topics and always is every election year is healthcare. What do we do with health care? We need Medicare for All we need this. We need that. Now. How about taking one thing that we're already paying for his tax dollars, converting it to something that the European nation is actively trying to ban 100% they're out, they're gone. We don't want to do this. And then what's really sad is when you introduce high fructose corn syrup, and I'm not trying to pick on anybody, but it's a soda company that ends in Ola. Ah, Mmm hmm. It's couple of them. Yep. You pick which Ola you want. Alright, so they've so they've looked at this, and one of the older companies did a real big campaign paid for their own studies, and got it introduced in Mexico. And now Mexico is almost caught up to us and diabetes, and obesity. And somehow, same thing happened in China. I mean, China says, FU to everything whenever they want, but somehow one of the older companies got in there, if you want to learn about that watch Patriot Act, because Minaj Hassan did a whole thing on this where he was like, How in the world can we not negotiate with China, but the older company just went in and said, pow do it. And now they're running into the exact same problems. He showed different commercials that they're running. And they had they, they gave them articles which show the same thing. Coca Cola has their own research institute, and they come out with things that say high fructose corn syrup is actually good for you. And you just need to exercise more. exercise more.Eric Rieger 19:37 Yeah, I mean, it's ridiculous. If if you wanted to make certain that your bank was secure, it would be a bad idea or policy to get the robbers who are going to heist you later to check your security system, because that's exactly what's happening here. It doesn't make sense to take the data from somebody who is wanting to sell you what they're telling you is safe just on the other side. Yeah. They're the only ones who have the data that show that. Think about it. If you're hearing that high fructose corn syrup is okay for you, who is putting together study? And what did they study? Interesting? Is there a study? Or is it just a kind of a? We feel like it's, it's okay, was there actual data that showed a reproducible, less than 0.5 p value?Ken Brown 20:26 I went down a little journal searching rabbit hole, because I did that thing you're not supposed to do when you read the whole thing. And at the end was, there's no way that studies so I started going through our Mendeley account and stuff, and then it said unpublished data,Eric Rieger 20:41 so they don't believe in it.Ken Brown 20:43 So they brought a PhD to stand up and go, it's good for you. We did a study on that. Trust me, it's right there. Right there in my brain. didn't even get it published.Eric Rieger 20:53 Yeah. I mean, if you come home and your newspapers torn up and the trash is out, and you ask the dog, did he do it? And they go, No, he did it. The dog did it. It's the same thing. They did. The the study is not real. They're just saying it.Ken Brown 21:07 Yeah. That happened to me when I was a kid once and I yelled at our dog, it actually was a raccoon.Eric Rieger 21:12 couldn't believe he didn't call me up or dog saying no.Ken Brown 21:17 All right. So even if you're sitting here, and if one of those scientists is listening to this, and he's like, no, I looked at the data. It's there. That's fine. Let's back off all that. Let's back off speculation. I want to talk about an article that was just published about two weeks ago. The title of the article is the negative and detrimental effects of high fructose on the liver with special reference to metabolic disorders published in the Journal of diabetes and metabolic syndrome. It's a lot, we got to teach these guys how to write their name. Because I got tired Listen, just kind of reading through the title. But what I just I'm gonna just go over the key points to this. Yeah. And then you make your own conclusion about this. So what this article looks at is let's talk about the cellular mechanisms. This isn't speculation anymore. This isn't taught let's just look exactly what's going on on a cellular level. Okay. So what actually happens is, we may have to put the nerd glasses on, I always carry him around in case it gets too nerdy when you go, you need to back off,Eric Rieger 22:11 Clark.Ken Brown 22:12 so got the nerd glasses on. Basically, you already know that fructose is metabolized in the liver. So I'm going to go through a five step process, okay, have a two part reason why high fructose corn syrup is messing you up. Okay. Okay. So we know since it's metabolized by the liver, step one, the liver tries to metabolize all this fructose that it's getting in, and it quickly cannot do it. So the liver converts it to triglycerides, or fat that so you start having these fat depositions in your liver, step two, the fat starts accumulating, and we call this fatty liver disease, right, the fat starts accumulating, and as a result of this, fructose becomes harder to metabolize. So in other words, the fructose is going, Hey, I'm here, I need to be metabolized. And these fat cells are just going like, man, we don't know what to do. Sure, because we're not built to do this, right. So then you end up with this snowball effect. And then that fructose that's sitting around starts impairing other processes, one of them being something called a beta oxidation process, where if you're a medical student, they go, Oh, that's how you break down fat. So you impair the ability to break down fat. So you impair the ability to break it down. And what that means is, is that it can't metabolize fat, so it leads to fat just sitting there, and it starts creating other problems. So step three, is a decrease in ATP, adenosine triphosphate. That is the energy that our cells you, you have to have it, I'm going to throw it back to the article that my patients sent me yesterday. So what happens is you get a decrease in ATP, which is the energy for mitochondria, that's the powerhouse in the cell. When this happens, the body increases and expression of an enzyme which I'd never heard of, and nobody's ever taught me this. So it almost feels like a cover up called fructokinase C. Okay, fructokinase C. So when fruto kinase c starts ramping up to get rid of the fat, all this other thing, it actually destroys more ATP, as it turns out, fructokinase C is a bad thing for around in your body. Sure. So it actually starts breaking down what little ATP you're making. And then this increases something called uric acid, which leads to a very vicious cycle of the fat not being able to metabolize, and then more fat comes up and then you start decreasing the cellular energy and now you've produced uric acid. And this vicious cycle actually creates severe stress on the cell, which leads to reactive oxygen species. I don't know if you Remember a few episodes back we talked about how one of the leading causes of obesity is oxidative stress. Yeah.Eric Rieger 25:05 RsKen Brown 25:07 Rs right there. And then guess what's happening. There's this battle going on, fat is just showing up because they don't really care. The body's trying to get rid of that. ATP is being used to try and offset this fructokinase C. And then you've got a mitochondria that are sitting there going, yo, we have no energy here, right? I've got no energy. And the brain cells go we have no energy. I'm gonna go forage. impulsivity, ADHD bipolar. So not only are you actually putting on weight, but you're starving, like there isn't. There's it's a lose, lose lose situation. Right. Does that make sense? Can Can you summarize that really quick? Because I feel like I got a little too deep in the woods.Eric Rieger 25:50 Sure. I think while we have someone here, briefly announcing this behind. Not really announcing us behind this makes no, it makes no sense. It's even throwing me off. But I do think that I could somewhat summarize what we're talking about.Ken Brown 26:04 I, I'll tell you what, I've been listening to what he's saying. He's like, Listen, everybody, if you're, if you're if you're here. Now, I just learned a lot about high fructose corn syrup. I want everybody here in the audience, too. And so I love that, that he's actually doing that for us. Thank you. I mean, I like it when we make that big of a difference that quick.Eric Rieger 26:20 Yeah, everybody's on board now. Yeah. So I what I do, when I hear is they bring in high fructose corn syrup, we don't know how to metabolize it, or our cells don't know how to metabolize it is now giving us too much uric acid, which I actually made me think of. There's a close association between high fructose corn syrup consumption and gout.Ken Brown 26:38 Yes, exactly. Yeah, yeah. AndEric Rieger 26:41 beyond that, when your body doesn't know how to handle this, you're just going to keep storing fat. And when it didn't have the energy, because you're destroying adenosine triphosphate, where you can't break it down to ADP, your cells can't, then essentially, it's going to keep looking for food. While you keep packing on fat. You're going to keep looking for food. While you're packing on fat, consume more high fructose corn syrup, pack on fat, keep looking for food, because you're not feeding yourself. You're not gonna keep burning the brain because the brain needs what it's not getting.Ken Brown 27:13 Yeah. So now part two of this vicious little cycle that's just going on in the liver. So as it turns out, the liver in its attempt to get rid of the fructose just produces tons of this Fructokinace C. Oh, can I see that then floats around and goes to my special origin, the small intestine? Oh, yeah. Where What does it do it inactive. It makes the cells insulin resistant. So this made total sense to me where that study that we've talked about before I've talked about with my patients, where people that drink diet, cokes, have a higher propensity to develop diabetes right? Now that makes sense. They're taking in high fructose corn syrup, even if it is in the form of some artificial sweetener and things like that. I'm always always like, man, how's that happening? Well, bacteria break it down. And ultimately, you end up with fructose and the liver has to, you know, do this insulin resistance, the fructokinase c creates insulin resistance through a process called glute five, and all those other imacon get as nerdy as you want on this. Because I don't want it to be an opinion piece. I want it to be like, Look, this is what's happening. Sure level. So then fructokinase C gets into the small bow where data causes leaky gut.Eric Rieger 28:29 It just is a never ending cycle. I have not heard one of the redeeming qualities. You told me you were going to tell me about high fructose corn syrup.Ken Brown 28:36 I thought we were just gonna do the usual Oh, it looks like it's associated with this. And I found this article where they're like, no, it actually does this little tiny thing here that leads to this that leads to this that leads to this. So now, I mean, we always talk about how bacterial overgrowth can cause leaky gut or intestinal permeability. We talked about how glyphosate does it. Now, if you're taking in high fructose corn syrup, you're developing intestinal permeability, which allows the endotoxins to actually get absorbed directly, which then go to the brain. leaky gut, leaky brain. That's right. So one of the things that I always tell my patients, we want to avoid gluten, I want you to avoid products with glyphosate. I actually mistakenly have not been saying the most important thing to take out of your diet is high fructose corn syrup. I've been harping on certain molecules. Now I realize oh my gosh, this could be the root cause of a lot of the problems. Okay,Eric Rieger 29:31 so this is a this is an important intersection, I think right here. And I think it's it goes for everybody go it went for me. It's not your fault. It's not your fault. We weren't told that because we weren't meant to find out about it. This was something I mean, our own federal government does subsidize corn. And the corn refiners Association presses hard every year they they compete with the Archer Daniels Midland. It's Edra, who run the sugar lobby, they, they fight over who gets the sweetener lobby money. I mean, and then they they're strange bedfellows they work together in, in in advocating sweeteners in certain foods. But the moment it comes down to which sweetener is going to go into your food, trust me, they fight over that. And Archer Daniels Midland who represents and Cargill who represent lots of sugar cane growers, they fight with the corn refiners Association. And I hate to say it, but in this instance, I sided with sugar, because at least it's somewhat natural, and our bodies, at least know what to do with it.Ken Brown 30:37 So imagine if I'm producing this, and I'm selling this to a large corporation, I came up with a molecule. When you eat sugar. You need insulin to drive it into the cell, right? When you have insulin in your body, it gives you the sensation of being full. How does it do it? Because when insulin is there, a hormone called leptin. Yep, a hormone called leptin goes up and says, yo, we've had enough to eat. So if you're somebody that really struggles with your weight, and you're over there going, I'm trying I do not know. And people talk about sugar addictions. And yes, we know that sugar can have the same effects as cocaine and things like that high fructose corn syrup will, will do the exact same thing. Oh, icing on the cake, high fructose corn syrup, blunts the leptin response. Yeah,Eric Rieger 31:30 well, I mean, it's already blocking what insulin does? Yes. So it now you're giving me a sweetener that doesn't let me know that I've technically had enough food, even though it didn't give me any calories that I needed in the first place. Exactly.Ken Brown 31:43 And so you've got the situation where it is the perfect storm, if you're a corn grower, or if you manufacture high fructose corn syrup. Or if you are a manufacturer of something that is processed foods, right? Or if you're an insurance company, or a hospital, or anybody that benefits with the detriment of health. It's crazy. It's like you cannot, it's all it's almost like a biological weapon.Eric Rieger 32:13 pretend for a moment, you're a junk food manufacturer, I'm going to come to you and I'm going to tell you, okay, Listen, I've got an ingredient, it's going to replace that sugar that you're putting in your foods. And at first, you're like, Well, why would I want to do it, because it's going to give you a longer shelf life, it's going to keep people coming back, they're probably going to consume three to five times as much as they normally would. And on top of that, it's inexpensive, because the government is is paying down the cost. Sold right sold because you don't care about the person who's buying it, you're just wanting to sell it. That's what they've done to you. That's what they've done to the public.Ken Brown 32:52 If you eat any fast food, high fructose corn syrup, if you're opening a package, high fructose corn syrup,Eric Rieger 32:59 go to you know, the other day, we're talking about ketchup, and we need to give credit where credit's due. Okay, so Heinz 57, ketchup and see it and all the grocery stores. If you go and look in most shelves, now they actually offer a natural, or organic Heinz ketchup now. And if you look closely there, it says, advertises no high fructose corn syrup, it's regular sugar. There's a reason behind that because the word is getting out. And if you want more choices like that, then make the correct choice for yourself. So with this show, we want to arm you with the information. This isn't really a joke, look at a picture of people gathered on the streets hanging out in the 60s and 70s. Again, just simply compared to today, I won't tell you what you're looking at, just look at a group of people. And then look at a group of people today. It does not look the same. And you can't blame it on laziness. I wasn't wanting to say this to laziness, there have been lazy people around for generations for centuries. They're lazy people that existed back in the 70s that have way worked out or whatever else. We still didn't look like this. It doesn't make sense.Ken Brown 34:05 I think we just gave a pretty compelling argument of so much of it is not your fault, right? And I hear that from my patients. They're try and then even well intentioned people going well, I meeting mine, I don't want to I have not done the due diligence to look, but let's just pretend like it's a Lean Cuisine or something. The fact that it's got a shelf life probably means it's got some high fructose corn syrup. Yeah. And if it's got some high fructose corn syrup, all this stuff is happening to you. And at the very top, it's you're not going to get full, because you don't have a hormone that says you're full, and then it just starts dripping down. Oh, your brain is going to be starving. So you're going to be more anxious, you're going to have anxiety, you're going to have impulsivity, oh, and then all of a sudden, you're getting fatter, your liver can't process it. Now you've got intestinal permeability. And then the one thing that is my passion, that probably is the least relevant to everybody out there, it affects the microbiome, you decrease your microbial diversity. It's not. It's literally poison.Eric Rieger 35:09 It's poison. And I did challenge yourself. So you'll notice they're like, I don't mind giving these guys a shout out, Justin, Justin's little peanut butter chocolate.Ken Brown 35:19 Yeah.Eric Rieger 35:20 So what makes Justin's unique if you pay attention to it, they are made with real sugar. And so all of the different flavors of Justin's peanut if they have something sweetened, because they also have just like nut butters and things like that. But they're Almond Butter Cups, peanut butter cups, a walnut Butter Cups, or cashews, whatever it is, but they're all made with regular sugar. And then they may be slightly more expensive, but just go and compare that to your standard gas station candy aisle. I'm not gonna have to say any names. Just go look, the first ingredient is going to be high fructose corn syrup. It's cheaper, they don't care. And of course you want it. You want it because your brains been programmed to want it. That urge just make the leap and start fun. I'm not I'm not at this point. I'm saying avoid sugar, just pick the right time. And it will at least start allowing your body to react appropriately to the sweetener.Ken Brown 36:13 Absolutely, you can you can retrain, you can do this. We, I feel like I tilt at windmills, you know, the Don Quixote style, I feel like I tilt at various windmills. I just I don't know how I missed this. It's, it's like it. It's been camouflaged. Yeah, out there. And I'm like, that's the truth thing that we need to make our mantra here.Eric Rieger 36:36 Another thing to think of to kids, if you're making your kids lunch, check the bread. In our I purposefully went through the grocery store that we have close to our house here recently, and just checked all the different breads, there's a I think I counted, there was a 47 different kinds of breads and bread brands to, to mass produce bread brands had a line, not even all of the lines had a line that didn't have high fructose corn syrup. And like their wheat bread, for instance, the rest of them do,Ken Brown 37:10 don't buy that. Well. And then the other thing, they're catching on to this. So I started looking at labels. Also, it goes by a bunch of different names. Oh, almost made up names by the food industry, where they and I wrote them down someplace because I was like, so annoyed by it. It's like they when you look it up, you're like, Ah, that's high fructose corn syrup. And they call it like something else, like whatever. And other countries are starting to do this now where they'll name at different things. So it's like, okay, to avoid it, try not to open packages, refined foods, try and eat those whole foods on the outside of the grocery aisle where they really want you to walk in, go down that middle aisle, they want you to hit those cookies right away. Because that's it's cheap for the grocery store. They know that you're going to buy them it's hard to not buy it that go on the outside, get some whole food first. And then really try to because once you start that path, it's it's super, it's super hard. So I don't know, I it opened my eyes to be honest. I mean, one of the reasons why I love doing the show is that we I get the opportunity to take a few moments to look at something where I normally wouldn't. This is one of them.Eric Rieger 38:16 Yeah. And I love the show because we get to get into subject matter that just like you said, it's it's bringing something to your attention. I think that this is a topic that maybe I've kicked around with family members or friends but I even at times, I don't know how seriously I took it until I decided to do the research myself I my last soda, my last sugared high fructose corn syrup soda was several years ago, but that was buying. That was on purpose. It was by design, I wanted to stop consuming that stuff. It wasn't easy, but doing it, I feel better doing it. And I want I just really want everybody else to have the same opportunity, same information. There's no reason for us to keep in this crazy cycle. We only live once of feeling sick, not feeling our best. I want you to enjoy your life. There'sKen Brown 39:06 no reason to do this, the idea that on a federal level, we're paying taxes to produce this to make us sicker. I mean, if I were a politician, if I were in charge, I'd be like, subsidies are now shifted to fruits and vegetables, corn, you've had your run. No more grandfathered in subsidies. You can't just have excess corn you don't know what to do with. So you're gonna, you're gonna convert it to high fructose corn syrup. We're going to feed it to our animals. We're going to do this. I know that there's a role for it. I also know that it's, oh my gosh, I was trying to do some research on this. And I discovered a Netflix video called corn or something like that. Okay, this is this is wild. It was in Iowa. These guys from Boston, found out that they had relatives generations before and they wanted to see what it's like to farm corn. So they got a one acre plot and then they kind of lived in this little Iowa town. I'm about halfway through it, but it's really this is really awesome. So they planted their corn, and then weeds started coming up weeds. And the guy pulls it up. And it's hemp. Oh, wow. It's hemp. That's how much hemp is wants to grow. It's like I want to be here. Yeah. And then what do they do? Very good, glyphosate, whatever thing and they just kill everything in between the corn. And then all of a sudden, you're taking high fructose corn syrup, and you're adding glyphosate and chemicals and stuff to it. And so we're taking poison, I'm going to give you arsenic, and then you're going to mix it in gasoline and drink it.Eric Rieger 40:35 It's funny the same as getting gasoline, because they also make ethanol and all that excess corn. Hey, yeah. I mean, just, I don't know, this episode is a great, a great introduction for our next show.Ken Brown 40:48 Absolutely. That's the whole purpose of doing this, that we understand that, you know, this is a lot to be thrown at you. But just take a second to look at it. And look at least look at the various names are calledEric Rieger 40:58 One last thing I wanted to call back on a recent but previous episode, we had one two shows ago, I believe might have been three, where we talked about the increase in gi cancer in people. There is another study that we can't get to today, it's very, very in depth. Well, it's not just one size, there's several. But there's one that really ties together our current day food additives, including high fructose corn syrup and the increasing incidence of gi cancer. It's not a joke. It's not something that we're just trying to say, Oh, don't eat sugar to not get But no, in fact, eat real sugar. If you have to have a sweet tooth, the studyKen Brown 41:35 results were pretty simple. The equivalent of one can of soda a day resulted in increased cancer in mice.Eric Rieger 41:42 Yeah. It's It's not good to say it's and it's horrific that our that our government subsidizes it and you mentioned it earlier, you can change the name of how you see them the label, you know how hard it is to to put an all natural product and what it is on a box. It's actually good for you. The FDA is really hard on this.Ken Brown 42:02 Yeah. So in case your Eric's now holding up a box of atrantil no high fructose corn syrup, and I'll turn to no so no additives, no additives, so it'sEric Rieger 42:11 a little annoying. Well, regardless, I'm prettyKen Brown 42:13 pumped about our next show coming up.Eric Rieger 42:15 I am too so be certain to check out 42 right. This is 42 next one's gonna be 43. Thank you. Paul Rogers went on the road with us by the way. Yeah,Ken Brown 42:24 this is a special thanks once again to Southern Star All natural brewery. Southern Star here,Eric Rieger 42:33 the whole thing. But seriously, so Episode 42. I think it's gonna do it for today's show, or for thisKen Brown 42:38 particular show. Yeah, I'm proud of us in so many levels. This is the shortest show we've ever done. How manyEric Rieger 42:43 minutes is that? We're at like, 42. We're only 12 minutes over. Well, thank you so much. This Eric Rieger with my co host, Kenneth Brown. that's gonna do it for episode number 42. Be sure and check out the show notes. We've got information on getting in touch with Southern Star brewery as well as a think we may end up adding after we published some information on where we can find some of the studies specifically on high fructose corn syrup, and it's dangerous to you.Ken Brown 43:10 Yeah, absolutely. Thank you so much for tuning in and definitely tune into the next one.Eric Rieger 43:15 All right, see y'all then

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This episode covers the latest knew regarding Gym Shark, cool app Mendeley, carb cycling and the beginning of how to set up a perfect workout.

Gut Check Project #40 with Dr. Tom O'Bryan

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Play Episode Listen Later Sep 3, 2020 81:30

Eric Rieger 0:00 Hello It is now time for the gut check project KBMD health fans and those at the Ken Brown clinic. I'm here with my guest host, Dr. Kenneth Brown. We've got an incredible special guest with us here today Dr. Tom O'Brien joins the show. Like and share of course, Dr. Brown once you take it away and introduce our awesome guests. Ken Brown 0:19 Well, I'm so excited because Dr. Tom, you and I have been running in similar circles. And every time I bump into somebody including different lab companies, including different mindshare people, everybody's like, Hey, you and Dr. Tom need to hang out. I'm like, I keep missing him. I'll go on a summit and he'll be like before me or after me. And then I'm just like, Oh, this is awesome. So we finally got you, wrangled in, you've got so much stuff going on. You're an author, you're a doctor, you obviously do some incredible deep dives. And what I love about you is everything that I've seen you on a webinar on a summit is science backed and that's exactly what we do. So I'm just thrilled I I have no agenda for this. You got a ton of information. If we ended up talking about something that I need to learn about, I'm just going to peel off and say, Wait, explain that. And that's, that's for me. So I'm not trying to question you, but like, sure, where I've read some of your stuff. And it's pretty cool. We're talking the same stuff, fix your brain through your gut, that kind of thing. That's all about us. So, welcome. So excited. Dr. Tom O'Brian 1:18 Thank you. Thank you so much. And I'm thinking a place to start if I may. The Alzheimer's Association came out last year and said one out of three elders dies with Alzheimer's or another dementia. So that means between the three of us, one of us is going down in our brain function, and it ain't gonna be me. Ken Brown 1:42 It's gonna be Eric. It's gonna be Eric.Eric Rieger 1:43 This is unfair.Dr. Tom O'Brian 1:44 I feel like I understand. But that's a reality check. And with a reality check like that, whether we like it or nobody likes to talk about brain function, no one does. You know, we all know someone that had a heart attack and survived. They changed their diet, they started exercising, they lost 25 pounds, they look better than they've looked in years. Most of us know someone diagnosed with cancer that went through the recommended protocols. And they're doing better than they've done in years. No one knows anyone diagnosed with a brain deterioration disease that's doing good. It terrifies us. And so we avoid the topic. So I want to talk about first the reality check that our healthcare system is not quite working the way we want it to and more people are getting sicker, especially if we talk about the brain and kids with autism and the numbers are skyrocketing and all that, but how can we look at our health care if our bodies aren't working the way we want them to right now? What's the big picture view of that? How do I get a big picture and I want to suggest this concept because I have found that this works really well. When I moved from Chicago to Southern California in 2010 I needed a map. How do you get from Chicago to San Diego? You need a map, you know, and I may know how to get to Denver cuz you just get on I 80 in Chicago, it takes you to Denver, right? You know, I may or it actually doesn't, it takes you close and you have to go up and 94. But I don't know how to get to San Diego, you need a map. When your body is not working the way you want it to you need a map. You can't just look for a better form of vitamin C, or what brain nutrient Can I take to help my brain function better? We have to have the map and what is the map in healthcare. The map is understanding at a layman's level, how I got to where I am and if we don't. To understand how we got to where we are right now, we are just like a dog chasing its tail trying to get somewhere else. So the question about brain dysfunction, or the question about auto immunity is, why is the immune system attacking my own tissue? Why is my brain not functioning the way it's supposed to, and you have to do a deep dive. And you don't need to be a geek and know the science because there's lots of information out there now. But we have to be willing to be uncomfortable for a little bit of time in being overwhelmed with knowledge. And we take it just one step at a time. That's why the subtitle of my most recent book, you can fix your brain. The subtitle is just one hour a week to the best memory, productivity and sleep you've ever had. And it's not cutesy subtitle It is the only way to be successful at changing the direction your brains going. Because as you learn more and more about the things that you didn't know, you mean that little bit of mold on my shower curtain there, it secretes spores into the air every time I take a shower, and I'm inhaling those spores and they go right up to my brain. And the number one type of Alzheimer's of the five types is called inhalation Alzheimer's, meaning what you're inhaling is causing the inflammation in your brain killing off brain cells. Yes, change shower curtain, you know, or whatever the trigger is. People don't know what the trigger triggers are. So they don't know what to do and they're hoping for a magic pill. You need the map. How did I get to where I am, so you then can make the corrections over six months to a year that turn your health in a new direction.Eric Rieger 6:00 I agree with that. I think that with where you're where you're beginning here in our discussion, many of the things you listed there, there's a lot to unpack, but many of the things that you listed there are, I think some huge tenants that that we discussed here on the go check project. One of those is that gut brain access, Dr. Brown talks quite a bit about the relationship for brain health and how it begins really with systemic health, which obviously originates in the gut. And then you're talking about issues of, of nerves and obviously the brain is a bundle of nerves but neural health and so what is it specifically that we need to do to protect our bodies from I would assume you're getting to long term inflammation what what the caveats are there that are initiating those inflammatory responses? So is there something that you wanted to kind of peek at there were Ken Brown 6:51 Yeah, so love where you're going with this. I'm um, as a gastroenterologist what I'm seeing is an exponential growth of autoimmune disease, Crohn's all sort of colitis are those celiac disease. Those are the ones that I deal with. And we're seeing this huge exponential growth. What you're describing is one in three people getting Alzheimers, we are seeing that autism is increasing. there's a there's a common theme here. And it's this upward hockey stick that's going on with chronic diseases. I love everywhere you're going and you I'm my bandwidth is only so large, where I have to kind of focus on how do I improve your gut to improve your brain and now you're talking other aspects. I want to get into that, but I want to know more about the guy. I'm a real big fan of how I built this. So I want to know more about the guy, the doctor Tom, how did you end up deciding that you were going to go down this path? I've heard a lot of your lectures so I know that you're super smart. I know you're very well read, but I don't know you. So let's talk about you for a moment. Dr. Tom O'Brian 7:52 Sure, sure. When I began my medical education in chiropractic school, very first week, the very first week I knew absolutely nothing. You know, we're working on a cadaver. I've just seen a dead body for the first time learning how to work with cadavers and genetics classes. There was a sign Dr. Sheldon Deal. Mr. Arizona was coming on campus to give a talk on Wednesday night. My very first week. This was the first week of January 1978. And I thought I'll go listen to this guy, Mr. Arizona bodybuilder, he's going to be a healthy guy. So I go to the talk. He has a color television on a stand in the room and back then color televisions were pretty new. And so to see all those colors, you know, he had the television on but the volume offand he walked over to a desk opened his briefcase to pick out a bar man, an iPhone, walked up to the color Television holding the iPhone like a flashlight you know policeman holds a flashlight up Hi, walks up to the color television with this bar magnet, the picture turns upside down and walks away. It goes right side up and walks towards it goes upside down. walks away it goes. Right? In attic pollution does to your brain and your nervous system. It's called neurological switching. These are people that say right, when they mean left, they write the number three backwards. they they they just are confused. And it was the first evidence in my mind the first introduction to electromagnetic pollution Ken Brown 9:51 1978 he was talking about in 1978. That's crazy.Dr. Tom O'Brian 9:55 Yes, because he he was talking he was talking about batteries in a watch and because they were fairly new, and when you put a battery next year body and this was a watch that it can for sensitive people, not for everyone but for sensitive people. It can be the straw that breaks the camel's back. And it impacts on their neurological organization, and how their their brain and their nervous system functions. Nowadays, we take it for granted Of course, we wear watches with batteries, and we put ear pods and our years we put batteries next to our brain. And, you know, we're using headphones that are remote wireless, so more batteries next to the brain. You know, I'm a strong advocate that we never put a cell phone next to our head. You either use the speaker or you use a corded earphones so that you're not putting especially for children whose skulls are thinner and these electric magnetic waves penetrate through a thinner skull of a child. And now there are so many studies on that. That's why in the book, you can fix your brain. I talked about the pyramid of health. Remember, we're still looking for a map here. How did I get to where I am? So in a pyramid, we think there's three sides to a pyramid. No, there's four. There's also a base. So the base is structure. That's the home of chiropractic and osteopathy, and massage and pillows and orthotics in your shoes and is your car seat tilted back. So you're driving like this all the time. That's, that's structured the base, then there's the biochemistry, the one that we all know about. And that's what we eat and drink the air we breathe. Then there's the spiritual or emotional and then there's the electromagnetic. So whenever you have a health concern, you have to look at all four venues to see, where are the triggers that are contributing to my body not functioning the way it should. So that was my introduction in January of 1978, to healthcare. And from that, I started looking in the literature and I found some children living within a quarter mile of high power tension wires had higher incidences of leukemia. That was 1979. I think I found that first study. And by the early 80s, mid 80s, there are many studies coming out about high power tension wires, and people's health if they live near that. So that validated for me, that for some people, electromagnetic pollution was a problem. Not for everybody, but for some people. And the same is true about structure. For some people. That's the problem. For some people, it's stinking thinking, the emotional or spiritual side and You can see the studies on stress hormones inflaming or triggering type one diabetes and triggering autoimmune diseases was what we think that or how we respond to stress and the hormones we make that set that up. For some people. That's the trigger. It's all about finding the map. So my entire career has been based on always asking my first mentor, no, my second mentor. My second mentor was Dr. George Goodheart, the founder of applied kinesiology, the muscle testing that some doctors have seen. Practice night have hundreds and hundreds of hours with Dr. George and he would always every weekend in our seminars, and usually they were at the Marriott Hotel at the airport in Detroit. So people fly in from all over the world to listen to Dr. George and the the podium that he's stood on was a wood podium. And he would do this all the time. He would say, lift up his right knee and his right arm and go, Why doctor and slam his foot down really hard. So we all kind of jumped in our seats now, because that would stage would just like bounce a little bit. Why do they have what they have? Why is your patient complaining of dot dot dot? And he would consistently drill into us Why? So my entire career has been based on why is that happening? You know, for example, why is it? We've all heard that it takes 20 minutes before the hormones in your gut. Tell your brain that you've eaten enough? How come you don't feel full right away with the volume of food you take in? How come you have you eat a little bit more and they say, Oh, I'm really full. How come that messaging is delay. I don't really know. But doctor Ken , you might, you know, we could have some discussion about this. I just made this up. But I think it's because we have the same body as our ancestors thousands and thousands of years ago, bodies function exactly the same. And a primary concern for our ancestors was getting enough food. They didn't get three meals a day, they ate when they found food. So even when they're full, maybe they should eat a little bit more because they might not get it next time. And so they get an extra few 15-20 minutes of eating the berries or eating the nuts or a little more meat on a harvest they made because they might not get a meal for a day or two. And I'm just making it up as to why I've never seen anyone write about why that is that that happens. But that's that was my thought about it, but always why. So I've been asking why my entire career.Ken Brown 16:01 So the why this is really interesting. So the when was 1978? The How is these mentors that have come to you? And then the Why is how do I do this? So then the how I built this, where did you go from? Okay? I am learning a lot from these experts, I have decided to shift my career focus and put in you've put a ton of time into developing summits into writing books into I mean, your your website is just got blogs that are just stacks and stacks deep. So when did you make this decision to go, I'm going to really commit to this aspect. And I'm going to become a thought leader and a teacher about these kind of things. Because clearly, you're passionate. But the as, as a physician myself, it's finding that time it's saying I'm going to take this, this leap off this dock, say I'm going to commit to this. I feel so strongly about it that I'm willing to put myself out there.Dr. Tom O'Brian 17:01 My third mentor was Dr. Jeffrey Bland. Who I heard Dr. Bland first talk in Chicago in 1978. And he is the Science Guy. Ken Brown 17:15 78 was a big year for you.Dr. Tom O'Brian 17:16 It was a big year. It was a very big year, married in 77. Went to school graduate school in 78. met these incredible mentors. You know, I think my angels just guided me to these guys. It was unbelievable. And but Dr. bland would say now this doctor in the New England Journal of Medicine said this and oh here three years ago, in the British Medical Journal, they said this and right here last week in the Journal of American Medical Association, they've said this, do you see how these pieces come together? And Dr. bland has always been about asking why and understanding at a deeper level why things can occur from a science level. So Dr. Goodhart was all about clinicians and being a clinician and finding out how things work. And sometimes he made up the reasons because he wasn't as much of a science guy, as Dr. bland. so bland is talking why from the science goodheart is talking why from the results. And so what happened? Was I just with every patient, I just kept looking to see, why is that happening? Or if they're not getting the results that I think they should have gotten? Why is that not happening? What am I missing here? What am I missing? And so I kept I keep looking and looking and looking. I'm not content when they feel better. And I mean this with the greatest of respect, I don't really care how they feel. They don't come. They come to me because of how they feel. But they're really coming to me to have their bodies function better so they live a long and vital life and how they feel is transient. So whether I get them feeling better right away is secondary to identifying the mechanism behind why their body's not functioning properly, Ken Brown 19:11 love how you said that, so that how they feel is transient. And the first thing I thought of is how many people come to me. And they're on multiple anxiolytics and multiple antidepressants, right? And I read the notes from the other doctors and they're like patient reports of feeling less anxious. Plus, check. Beautiful, there it is. But now I'm dealing with side effects of eight different drugs. And so I like how you said that how you feel is transient. I need to know why. I love Dr. Tom O'Brian 19:38 Yeah, yeah, and of course, all of these drugs, the antidepressants, the anti anxiolytics. They're all approved and designed to be used for a short period of time. None of them are approved for the rest of your life. But they're given to people so they continue to feel less symptoms. Ken Brown 19:56 They're approved to be given for short periods of time, but the pharmaceutical and I'm not passing the pharmaceutical industry. Many of these drugs if you try and get off of them create a tremendous amount of their own side effects. So knowing that, so Eric Eric's former life, the way that he paid for his crna school was actually as a drug Rep. So he's got some pretty interesting stories about how to make sure that you move some product.Eric Rieger 20:19 Yeah, no comment, but I don't work there anymore. So that's probably the most important takeaway. No, but I do agree with that. And I do think Dr. Tom, one of the biggest issues that I never liked about certain aspects of pharmaceuticals, which were intended for short term, to become long term is they're missing a very, very important piece. Once I've taken this to alleviate whatever the symptom or the feel, as you put it, there's no exit strategy. There's no way for me to break this dependency that I've now formulated to make me now feel this new normal. And that's, that's something to fear. I would, I think, to engage long term with a pharmaceutical that's just simply going to function as a feeling band aid. is taking care of the issue.Dr. Tom O'Brian 21:02 You're absolutely right. You know, and we've got so many cases of people on high blood pressure medication or on antidepressants. And we always say at the very beginning, now look, here's what's going to happen. There are some side effects to the medications you're taking. And you may have heard some, but I'm just want to make sure you know, these are the potential side effects. But we're going to address why your body has high blood pressure right now. So it's great to be taking these medications. You absolutely take them when you need them, and you need them right now. But as we address the underlying why your need for those medications is likely to go down, which means you're going to stand up and you're going to start getting dizzy because your blood pressure is too low, because you've got too much medication now. So I want you to call your cardiologist or the doctor who put you on that medication as soon as you start noticing any symptoms like this, this, this or this and say, Hey, I'd like to come in, and you come in and you say, you know, I'm getting a little lightheaded when I stand up now, and I never did before, but I've changed my diet. I'm exercising, I think I need less medication. Can you monitor me and we meet down when you think it's appropriate and safe. But just gradually wean me down so that I don't have any complications as my body's getting healthier. And every doctor is willing to do that every doctor and if they're not find a new doctor to monitor your medications.Ken Brown 22:36 So I'll stop you right there. And this is more for teaching me and with your style of practice. You have somebody that comes in you know that they've got the diabesity triad or whatever. And you look at them you go Okay, we need to start someplace. Do you start diet do you start environmental toxin do you start sleep, because I think those are kind of the three pillars might leave least knowledgeable aspect of that is environmental toxin because it's just something that I've not gotten into yet. And when you mentioned the breathing in the spores, I'm like, Yeah, I've got a lot of patients that got really sick when they moved into an older home and they renovated and then they've never been right. Since I've definitely believe that mold has a big role, but it's just the amount of time. So when you look at this, I'm challenging you to say this is where I start first, where is it? Dr. Tom O'Brian 23:25 Really easy, really easy. There is a great program that's been developed called the living matrix. And the living matrix is a, I don't know 30-40 page questionnaires. And it's going to take you, Mrs. patient, it's going to take you a day or two to fill this out. You'll come back to it and fill out some more of it. Someone's going to say how is the health of your mother during your pregnant pregnancy with you? And he will say, Oh, I don't know my mother passed. That's all right. Call your aunts. Call your aunts and find out. Did mom take any medications during the pregnancy with me, you get as much information as you can, and when you have a completed living matrix, this is the computer model, the program sets it off into eight different categories. And it becomes obvious which categories are the most out of balance. And that's usually the place that you start. And we'll start with maybe two or three of those categories, depending on the individual. Some people, it's clear, their auto immunity happened within three months of their divorce, or within three months of being sexually abused. And it's clear, they've got to deal with that energy. And so that person needs to include in their protocol, a therapist that they feel really good working with about this particular topic, because that's not my category. But if it's not address, it's going to thwart the progress radically. Ken Brown 24:59 That is so interesting. That's that insult to injury that I have to have that discussion with so many patients where I have somebody that comes to see me and they're like, yeah, it's unfortunate. I went to this horrible divorce. And then I started bleeding out my rectum and then I diagnosed them with raging ulcerative colitis. So like, what is the bad luck? I'm like, I hate to attribute it to bad luck. I attribute it to a sequence of events. Dr. Tom O'Brian 25:22 Yeah, exactly. Right. I agree. Yeah, that is totally agree fully agree. And and the tool called the living matrix of every patient fills that out. I have lots of people, you know, we we did a docu series called betrayal, the autoimmune disease solution. They're not telling you is that out yet? Okay. It is it is. And we've actually had over 600,000 people watch it. When I make the living matrix available to people and I think probably four to 6000 people have filled it out. You know, it's great because it's hard to read until you understand how it works, but it gives you a lot of information. And all of our patients fill it out before I'll ever see them if they don't fill it out, or they fill it out halfway. I don't see them. If I if I see that it's only half done. I call my staff because I'm virtual now, you know, so I do virtual consultations. But as I'm looking at the results here, and I'm looking at the screen and living matrix, you know, if it's not filled out, I call my staff and I say rescheduled or they put the time and I'm not putting the time in until they do if they do it half ass, I'm not going to do it half ass, and so cancel them, and don't charge them just cancel them. And if they want to come back, do it right. You know, you just don't put up with that. And I talk on stage all the time to doctors. You can't put up with someone who's putting their toe in the water. They're either going to do a deep dive with you, whatever your skill set is or they're not and in our practice, we represent that our goal is to help them see the map of what's happened to them. And so if they can't, they can't see the map. If I don't know the history, it's not possible.Eric Rieger 27:16 Well, that's actually pretty, pretty impressive because in a different in a different way when we've had patients who've come through the clinic, and then we've, we've prepped them to, to scope and I'm addressing anesthesia and of course, Dr. Ken over here is discussing with them what to expect as they continue on their journey. Something I've heard him address is, it doesn't matter necessarily what led to where you are right now, whether it be your fault and all of them or none of them. But it is your responsibility to engage with the change that's going to make you better. And you've had that conversation with with plenty of patients and it really just doesn't matter what to this point we can identify the triggers, which of course helps finding the solution. But ultimately, there's going to be self responsibility for one's own health. And you've got to be able to commit to whatever that change happens to be. And I would say that really the the gut check project that this whole the whole reason for this podcast was, we felt that there are better solutions than just taking the old didactics from the pharmaceutical industry and antiquated medic medical school iidx to solve problems. Mother Nature has lots and lots and lots of tools that we don't all, you know, use which are free available. And if you just have the discipline to stick with it for your own interest, you'll find in most cases, a better health, healthy living style, I guess you could say, Dr. Tom O'Brian 28:48 well, you guys are in a unique situation that you have to do the tests to identify where they're currently at. You've got to be able to clearly say you've got ulcerative colitis, it's at this stage and it's in this area of your colon and Okay, so we need to calm down this fire, calm down this inflammation while we look to see where it came from. So you you guys have both areas that you have to address and I do this on stage a lot and you know doctors laugh at it, but I've had a number of people come back to me years later and thanked me that they implemented this. When I I tell patients that my favorite patients are the ones that say I've been to Mayo Clinic and they don't know what's wrong. And I'll say that's great. Congratulations. And they look at me kind of startled. You know, they heard I'm a nutcase. But Congratulations, that means you don't have a disease. Because if you've got a disease, Mayo Clinic would find it. You've got dysfunction, something's not functioning right. So the test we're going to do or not the same test that we're looking for disease, we're going to do functional tests. And I hope that we find some functional tests, and people will and sometimes their insurance won't pay for it. And then some patients will say, Well, I can't afford that. And I say, Okay. Oh, okay. And then I write down in their file. Patient refuses this recommended test due to finances? And please sign this. Well, why? Why would I sign that? Because you're asking me to work with one hand behind my back. And I'm going to do everything I can to be of service to you. I will do my very best, but I'm not responsible anymore. If a problem occurs that I miss something, because well, no, no, that's okay, Doc, I'll sign it. Okay. Or no, no, no, I'll do the test. I'll do the test. Okay, good. Because I've seen so many people that say I can afford it. And two months later, I see him in the shopping they've got a deep tan because they just spent three weeks in Mexico, on vacation. It's just a priority thing. And if someone really can't afford what they need, well, our services will always reduce our services for finances if it's true, but we need patients to take ownership and responsibility to be actively involved with us. as we're going through this process. Ken Brown 31:28 When you started this, you open with Alzheimer's and it's funny because I kind of do that with my patients where you said that one in three people will now develop Alzheimer's. And then you tell me Alzheimers Association says that Alzheimers Association, so and then you talk about a patient that cannot afford to do X, Y and Z but you see them with a deep tan. So I use the let's fix your gut to protect your brain later in life. Because I'm I personally and I try and teach my kids this. I've got a 15 year old, a 13 year old. And my wife and I are on the same page where I personally prefer to purchase memories, as opposed to things. So I'm perfectly willing to take us on a trip, have some incredible meals, have some great pictures that we'll revisit. And rather than purchase something else, and what I mean by that is what is that memory worth? That memory is worth so much more than that object to me. And then if you were to say that I'm going to take away all those memories, meaning I'm going to take away your life, that's the panic moment with me, that's when I want to sit there and say, I want you to change your diet, I want you to change your lifestyle, not even so much is it so much a physical thing. It's not so much so that you can have the Beachbody, it's not so much you can do this. It's so that we protect your brain later. It's so that the same concept of osteoporosis prevention in your 30s so that we're not dealing with it and you're 60 so you're not busting a hip in your late 60s. And then now thing, what you're talking about, it's so true that you, it's hard to get people to think big picture like that. But you've always done this. So 1978 you have these mentors that do this. When did you decide to really say I'm going to be part of the movement? And I'm going to develop this website? I'm going to spend, I mean, you've been prolific. You've written books, you lectured you do some crazy summits. Man, you're gluten summit. Some of the people you have on that are like my heroes. I mean, Alessio Fasano, I mean, I've been following that cat since you know, early on in his career and a lot of you get some some pretty heavy hitters. That's pretty impressive. How did you go from, I now need to make a difference. On a greater scale, I guess is what I'm saying. You've mentioned multiple stages and stuff like that. When did you go it's less from one to one it's more from one to many.Dr. Tom O'Brian 33:53 January 2013 my friend, I think our friend I believe, you know, JJ Virgin. I've known JJ for many, many years. And she used to call me or I'd see her and she said, I just went to this weekend seminar was fabulous. You know, they're talking about this marketing concept of how to get information out to people in sales. He she said, You should come and say, Oh, yeah, thanks. Thanks. And then she hired a consultant, Allie, and he called me and said, I just signed the contract and I'm working with Allie. I'm gonna learn how to do this at a bigger scale. Come do it with me. Yeah, how much? $10,000 it ain't happening here. It ain't happening. Right. And then JJ grew and she grew. She applied to Princeton. Ken Brown 34:45 JJ is pretty convincing. when she gets passionate predicaments. Dr. Tom O'Brian 34:49 Yeah. And then she called me and said, Look, I'm having a seminar. I'm having I'm hosting a seminar, you're going to be there. I'm going to hire somebody to come grab you by the nape of your neck and bring okay, okay. Okay, welcome. So this is January 2013, dropped my jaw to hear how the participants there would do one thing that they prepare a webinar or something. And they would have 200 people attend, or 400 people attend just drop my jaw of the impact factor that was magnified by learning how to use the internet. And so I made a declaration that weekend. I said, you know, I'm a geek, and I just read a lot of science and I know these guys are I've been in their seminars where I've seen them at symposiums. I'm going to interview a number of geeks from around the world. And I'm going to put it online. Would you everyone here in the audience helps support me in this by send out announcements. And they all said yes. So my first interview, you'll really appreciate this Dr. Ken. My very first interview ever was Professor Michael Marsh, and our the marsh Godfather, the Godfather, celiac Marsh one Marsh to Marsh three, the Godfather, and he and no one had ever interviewed him. He was 74 no one had ever interviewed and he took me by the arm and walked me around Oxford and said, Tom, that's, that's right, right where I stood, and that and I received my medical degree in 1962. So that's great professor or took me down in the bowels of the library from the 1800s and that's where he sat to study every day. And you know, so Marsh, the Godfather and Professor Fasano, Harvard and so many others from around the world. Umberto Volta chairs the celiac Society of Italy. And I interviewed all these people. And everyone who's a JJ's event, sent announcements out to their people. We had 118,000 people attend Luton summit in November of 2013. It was the first online. The first online health summit ever was the gluten summit. And we made it up. Ken Brown 37:25 And that was when 2000 what? Dr. Tom O'Brian 37:27 November 2013. Ken Brown 37:30 I mean, thousand of those people were still doing dial up. Yeah.Dr. Tom O'Brian 37:35 That's right, you know, and the weekend I came back from making that declaration, I mean, I was fired up. I get a message. And this guy emails me and says, Hi, my name is Bob Roth. I am the social media director for the University of Chicago celiac center, and I'm out in California. I'm wondering if you did have time for breakfast, and I said, You i'm sure so we had breakfast and Bob said, you know, Dr. O'Brien, everyone's University Chicago thinks you're a nutcase. You talk about you talk about gluten sensitivity outside of celiac disease. And but I watched one of your presentations was recorded, and you're just talking science. I said, Yes. You said, you're actually correct. And I said, I know. I know. He's and I said, Listen, Bob, I just made this declaration. I'm going to do this thing. I'm going to travel the world. I'm going to interview these guys. I know who to interview. And I'm going to interview them. We're going to put it together and we're going to do this thing online. Come join us. So Bob left the University of Chicago celiac center, and came to Southern California and was our social media person. And then we found a guy to who knew how to run this program I learned about in jjs weekend called InfusionSoft, which puts puts all the data together into one package and sends it online. And we hired Bobby from Tennessee. And we put on the gluten summit. And the next day, I mean, so many of my friends call him said, How did you do that? What did you do people like Deanna Minik and Mark Hyman and so many other my friends, how did you do that? And I said, Well, my friends helped me here. And they said, Oh, can can are my staff and we just made it up. When there was a problem. We made it up. And they said, can I talk to your staff. And I said, Sure. Then my staff came to me and said, Hey, Doc, they they want us to do this for them. We should start a company to do this. And I know man, that's not my thing. That's not my passion. You guys go ahead if you want to. That was the formation of health talks online which is hosted 10s of millions of people in the last seven years in different summits all over the world, they of course, that's where it came from.Eric Rieger 40:09 Sorry about that. I didn't mean to talk over you. But of course, you wanted to have people that were interested in what it was that you were offering. You also find some inspiration in the fact that there were that many like minded people who were essentially as you probably assumed, but now you confirm they're kind of starved for that information.Dr. Tom O'Brian 40:27 Oh, I knew I knew from the day I opened my practice about the frequency of weed related disorders outside of celiac disease. I knew it. The testing was just not accurate enough at the time to confirm it. But I put people on gluten free diets and they get better again and again and again. But it was a component of a treatment program, not just gluten free diet, but it was a prerequisite you have to do that. Sure, guys, I see that the battery on my computer's at 5%. I have to run into the other room and get the charger So I'm going to come right back to you. SoKen Brown 41:04 we're gonna love this. I love this conversation. So what's really cool about Dr. Tom is just how honest he's being. He's just like, Hey, I met this guy. He taught me something. I met this other guy. He taught me something, I met this, JJ comes up to me and says, Hey, come over and do this, and just pulls the trigger and says, I have a message that I interview out there. And the digital marketing era was really in full swing. Right then.Eric Rieger 41:30 the thing I felt the reason why I asked Darshan that last question was, to me it was it was eye opening, even when we met JJ is just seeing how many people were now gaining access to topics that simply were not being addressed when when we were young, or going through school, etc. And basically what I feel like Dr. Tom just illustrated here is technology has allowed us to take what has been either ignored or hidden messages out to the masses and then helping people where they couldn't find help before. Ken Brown 41:59 Yeah. Are you back with a Tom?Dr. Tom O'Brian 42:02 I'm back with you. And as, as, as you were talking about technology absolutely correct, you know, for years and years that they thought I was a nutcase because I would talk about wheat related disorders outside of celiac. And now we have the testing available that's very, very accurate 97 to 99%, sensitive and specific. And so with those kinds of tests, the test is called the wheat Zoomer, could you zoom in on problem? And with those kinds of testing, people see for themselves that their immune system is trying to protect them, whether they get sick when they eat it or not.Ken Brown 42:43 So you've said this three times now, which means that it has clearly been a part of your career you said they said I'm a nutcase. They said I'm a nutcase. They knew I was a nutcase. So you've stuck by this, but will you explain a little bit when you say that, they say I was a nutcase. That meant that as a chiropractor discussing these other aspects infringing on people's territory, was it that you were just so far ahead of the curve that nobody was discussing? I want to know why you feel why you Dr. Tom feels that other people viewed you as a nutcase?Dr. Tom O'Brian 43:20 Oh, it was obvious. It was spoken about. But the the point in that is, you know, when when you know, that science is on your side, but technology just hasn't caught up yet to confirm it. And you know, it's on your side, because you see the results again, and again, and again and again, and you keep seeing the results, but you the technology just hadn't caught up yet. Then either you go by the status quo, with all of these unexplained applications, and people Don't get well, they're the way they're supposed to, or are you willing to break new ground and say, you know, oh, no, as is negative, when they give up wheat, they feel so much better. Why don't you try it for three weeks, and let's see what happens. Well then, and they get better. Their their child's attention deficit gets better. And the teacher say the new drug, you've given your child's working really well. And it was just a gluten free diet. The other parents say, Oh, we, we didn't give them any drugs. So he's on a gluten free diet. And you see that again and again and again. I can't let what other people think of me get in the way of the service that I can do for my patients.Ken Brown 44:50 Because you took a really bold let's, let's dissect what you just set about that. You knew that certain people in health care, we're not saying the nicest things about you. And then you dove in when you said I don't want to treat a patient that just sticks their toe in the water, you dove into a digital marketing world where keyboard warriors love to play also. So you went from I know that some people are going to say not nice things, too, I'm going to embrace it on a level that nobody ever has. And I'm gonna teach online, which is a very, very bold thing, because not a lot of people have the guts to do that right. To be pushing the envelope. I mean, it's, you know, I mean, you talk about I've been talking about zonulin for years before we test it. And you said we'd Zoomer and that's how I got involved with vibrant wellness. I was like, Ah, you guys figured out how to check zonulin? Yes,Dr. Tom O'Brian 45:49 yes, yes.Ken Brown 45:51 Yeah. And when I talked to my colleagues, I mean, even when I talked to gastroenterologists, they looked at me like you're What are you? Are you one of those? nutjobs talking leaky gut. You're one of those weirdos talking gluten sensitivity. Um, you know, fortunately, I fortunately did not discover the internet early enough so I didn't have to put myself out there and have a successful career writing books and doing stuff like that. Fortunately, I still have to stick my finger in people's butts to make a living and occasionally interview somebody who's smarter than me that decided to put it out there on the internet and do things and do summit so that's a but it takes guts to do that. So are you there. Dr. Tom?Eric Rieger 46:35 Did he freezeDr. Tom O'Brian 46:37 sn Ken Brown 46:38 you froze there for a little bit.Eric Rieger 46:41 We can hear you. Okay. You guys go. How about that?Ken Brown 46:45 Okay. There we go. Okay, back now.Dr. Tom O'Brian 46:47 Okay. Yeah, sorry. Yeah, you're absolutely right. You know, you asked me why and how did I do this? A home that I have in every one of treatment rooms. Can Can you hear me? Okay?Ken Brown 47:13 Yeah, you're going in and out a little bit, but I think it's all right. Oh, we should go ahead and muscle through it. That's right.Dr. Tom O'Brian 47:19 Okay, okay. There's a poem that I when I read it I just resonated deep deep in my being. It's by George Bernard Shaw. This is the true joy in life, being used for purpose recognized as the Mighty One. The being a force of nature. Instead of a selfish, feverish little clod of ailments and grievances complaining The world will not devote itself to making you happy. I am of the opinion that my life belongs to the whole and it is my privilege to do for whatever I can, life is no brief candle to me. It's sort of a splendid torch that I have a hold up for the moment and want to make burn as brightly as possible before passing it on to future generations. So that's my creed.Ken Brown 48:18 I love it. I love it. It's awesome.Dr. Tom O'Brian 48:20 And and from that place, if you know about zonulin, and you know about leaky gut and you think a patient's got it and you don't address it, because of what our peers may think, in my mind, it's Shame on you. And I do that on stage with doctors all the time, who cares what your peers think? I'll give you an example of that one, and you'll appreciate this one 1986 Australia. gastroenterologist says, You know, I think that sometimes ulcers are caused by a batch said you are a nutcase. Everybody knows ulcers are caused by too much acid and you have to give antacids so what did this guy do? He does an endoscopy, puts a camera down into his stomach takes pictures of the healthy pink tissue of his stomach. And then he drinks a beaker of beaker of a bacteria called Helio backer pylori. waits for days until he's as sick as can be, does another endoscopy takes pictures of the many ulcers that are starting in his stomach, and then he takes the antibiotics to kill the bacteria waits about a week until he's feeling better, does another picture of the healing of the ulcers. Then he publishes that paper, then everybody knows he's a nutcase. But he proved the under shadow of a doubt sometimes, ulcers are caused by a bacteria and the World Health or I thought that was so important. They sent that paper to every medical society on the planet. Why? Because at that time, stomach cancer was the number one cancer killing people. And it often comes from a helium backdoor infection. So, this guy didn't care. You know, he didn't care. He done his work, and he still was kind of thought of as a weirdo out there. Dr. Barry Marshall. 21 years later, he wins a Nobel Prize in Physiology. And the Nobel committee says and this is the exact quote, who with tenacity, and a prepared mind challenged prevailing dogma and that's what every one of our patients needs.Ken Brown 50:49 a prepared mind. I like that exact word mind if you if you're tenacious, but you do your homework, you burn the midnight oil, the prepared mind with tenacity is an unstoppable force. That's awesome. That's love thatDr. Tom O'Brian 51:05 is just one hour a week. That's tenacity every Tuesday night after dinner every Sunday morning after services whenever it is, but every week, you're going to spend one hour learning more about reading the map of how you got to where you are just one hour a week. And in six months, you've changed the way you think you change the way you live your life. You challenge prevailing dogma, and your health is the benefit that you get from it.Eric Rieger 51:34 I love that. Ken Brown 51:35 I love it. IEric Rieger 51:36 mean, it's interesting that you use Marsh as that example, because when this guy sitting to the right of me developed Atrantil and went on to talk about why polyphenols are so incredibly important. I guess we're going on six years ago now. He used that example. And that it's okay to think outside of the box which is essentially what he was saying to challenge dogma is to go outside of this box that we have built around ourselves. If it weren't for someone venturing outside, we never would have made innovation. Ken Brown 52:08 And the beauty of the technology that has allowed you to have this stage where 600,000 people sign up for summon at one time, also allows us to share globally information in a way that we couldn't before. So when I sit there and meet with some of my colleagues, and they're like, oh, there's no science on that. I'm like, Oh, really, let me pull up my Mendeley account. Really, here's 8000 articles on what we're talking about. Why don't you start reading that and when in my world traditional medicine world especially in Texas, I think that different states a little more progressive, like California has always been a little more open to the functional medicine side but Texas, not so much coming around. But when the drug rep to my left over here when doctors say there's no science on that what they're saying is somebody is not brought me lunch with a detailed piece explaining what I'm supposed to say. That's really what I'm saying. And we're all really busy. And that is what it is. But it just happens to be just like you. You go, um, you know, I'm tenacious, but I'm armed with science, therefore, I can walk into this battlefield and hold down, even if they even if they call me crazy.Dr. Tom O'Brian 53:17 Yeah, cuz that's exactly right. Last week I did an interview for a neuro psychiatric psychiatry group. And the doctor who coordinated the interview, she said, you know, Dr. Brian, I heard you speak three years ago at our conference, and you yelled at us on stage. No one's ever yelled,at us on stage before your neuropsychiatrist they're the cream of the crop in their own mind. You know, they're legends in their own mind. Right. AndKen Brown 53:48 voices in their heads.Dr. Tom O'Brian 53:50 Yes, right. Good, catch. Good, good. But what I said to them if you aren't spending one hour a week, reading the current literature Cutting Edge literature in your field of expertise, shame on you. You're outdated, one hour a week. And nobody's got time for any of this. But if you don't do that you're outdated within a year. Yeah. And, and she thanked me. She said, You know, I took what you said to heart because it made sense. I didn't like how you said it, but I liked what you said. And the result is I've completely changed my practice in three years. Thank you so much. I really want to acknowledge you here on the microphone in front of all of my colleagues, that was such an excellent recommendation to us and i and i say that to everyone. Whether you're a general public, or a health care practitioner, one hour a week. That's what it takes to have 10 that's tenacity and then prepare your mind to challenge the way you think so that you can read the map of what's happened to your body so far,Eric Rieger 54:58 don't you one of the reasons why really enjoy doing our show is that I'm a better doctor because of it because I prepare for different things because I have to research a lot of stuff. When we talk about topics. You're the exact same way you have gone. You started with the gluten and the you went to the brain. You're looking at this now you've got different you've got the whole erm. Dr. Tom O'Brian 55:20 bottle immunityKen Brown 55:21 Yeah, but what's the name of the of the program again?Eric Rieger 55:25 betrayal, Ken Brown 55:26 betrayal, betrayal. Yeah, I was I was trying to think of that. So when you do that you automatically your passion will have you read this. So I'm going to ask for your help. Maybe it's not you. Maybe it's some other people that you meet, but we're running into something. So when I say my Mandalay account, I have a graduate student that I work with and she finds everything If you need anything, let me know just email me She will find it and get the articles and so we can sit there and look at some of this but I'm seeing something and I think that you're probably seeing it also and it is This weird it becomes down to a nerve, dysautonomia motility type situation that can be the underlying cause of a lot of gastrointestinal issues which then lead to neuro inflammation. And now we're getting to the vagus nerve and we're talking about this I've got some really sick people that come to me and they're they've all been to the Mayo Clinic they've all been to the Cleveland Clinic and they all have been told that it's functional this and that, that it's in their head and they all say you should start taking Prozac but these are really intelligent people really type a people that had very successful their attorneys or accountants and this and that. I'm seeing a trend here that the chronic disease is affecting the nerves that is it acetylcholine Do we need to start working on the you know, the, the vagus nerve, I don't know. But I it just feels like more and more people are showing up there. They're really trying what's your what's your take on that? Because if we can figure this out. That's it.Dr. Tom O'Brian 57:00 This is this is a PhD discussion that we're now getting into that is at the core of the answer to your question. Arguably the number one journal in the English language for children's health is the journal Pediatrics put out by the American Academy of Pediatrics. They published a policy statement, which means it's not an author, you know, if I were to get an article published in pediatrics as an author, I've scored top tier difficult journal to get into I've really scored but this is a policy statement. That means it came from the board of the Academy of the American Academy of Pediatrics, and they said the toxic substance Control Act failed miserably to protect our children and princes and adults. And it is The governing legislation at the federal level for all chemicals introduced into our environment. This was passed in 1976. It's still the regulating guidelines for all chemicals introduced into our environment. It the the guidelines are so cumbersome, that in 40 years, they've only regulated five chemicals or classes of chemicals in 40 years. Because the lobbyists were so successful in paying off the senators and the representatives to pass this legislation that has no teeth. The legislation says you have to show that the amount of whatever chemical a person is exposed to is toxic to them. When you pump gas and fill your tank with gas, can you sometimes smell the gas? Sure, of course. you're smelling benzene,Ken Brown 59:09 right? Oh, yes.Dr. Tom O'Brian 59:10 Benzene going up your olfactory nerves right into the brain triggering inflammation killing off brain cells right now. Right? It's killing brain cells. But there's no evidence that the amount of benzene it's inhaled while pumping gas is toxic to humans. There's no evidence you can't. There's no evidence that it causes a problem. But give me 30 years of smelling benzene once a week and how many millions of cells you've killed off. I'm warming up now. 2017. papers published that came out of Chicago 346 pregnant women and the eighth month of pregnancy They did urine analysis they measured Phthalates five Phthalates Phthalates are chemicals used to mold plastic. Most of us have heard of Bisphenol A or BPA Corona is one of the chemicals. They measured five chemicals. There are hundreds of chemicals but they just measured five. they categorize the results into quartiles, the lowest, the next, the third and the highest quartile. They then follow the offspring of those pregnancies for seven years. When the kids turned seven years old, they did Wechsler IQ tests on the official IQ test. There's not much in medicine, that's all or every This was every every child whose mother was in the highest quartile of Phthalates eats and urine and pregnancy compared to the children in the lowest quartile of Phthalates and urine and pregnancy. Every child in the highest score tile, their IQ was seven points lower than the kids in The lowest quartile of Phthalates seven points. That doesn't mean anything to anyone until you understand one point difference is noticeable. A seven point difference is a difference between a child working really hard getting straight A's, and a child working really hard, getting straight C's, right this kid in hell because his brain never developed properly. And then just go to Google and type in Phthalates and neurogenesis, nerve growth. Here come all the studies, how balades inhibit nerve growth. And you see this and you wonder why Autism is going up and attention deficit is going up. You see this and then you go back to the pediatrics article and you read that is 247 pounds of chemicals manufactured or imported into the US United States every day for every person in America 247 pounds, that's 27 trillion pounds a year, take the population of the US multiplied by 247 times 365 days, it's 27 trillion pounds.Every newborn child in America has at least 200 chemicals in their bloodstream at birth that aren't supposed to be there. Many of them are neurotoxins, brain time. You wonder why we're seeing this increase in disease. We all are walking sewage dumps, excuse me, but we are we all are because it's in the air. You if you sit in a room and you can see the sunlight coming through the window, sometimes the right time of day the angle and you see little dust in the air. That's what you're breathing. That dust is the family lychee From the plastic lines in the windows, they leach out family chemicals into the air for years. It's the scotch guard on the sofa, leaching out those chemicals into the air for years. It's the formaldehyde in the kitchen cabinets. If they're not solid wood, they're pressboard. They're soaked in formaldehyde, and the bathroom cabinets leaching out into the air for years. And we were exposed to all of this, all of that and we're walking sewage dumps. You wonder why degenerative diseases are going, why Alzheimer's and the number one type of Alzheimer's is inhalational Alzheimer's, it's what's your breathing. This is so overwhelming for people. When you get when you look at this map. When you see what's happening. It is so overwhelming. That's why you have to operate from the platform of one hour a week. Yes, because and so one week When you learn that the leftover chicken from dinner, you put it in a plastic storage container in the refrigerator. The next day the chickens got phalates in it from the plastic. When you learn that one week, you take that hour you go into my book and there's the three URLs to order glass storage containers, and you go to miles, kimball.com and Amazon, whatever the third was, Oh, I like those. And yours three round ones in two square ones and one for the eyes. You pay with your credit card, you hit send, it took an hour, you're done for the week. Like that. Never again, will you poison your family with minute amounts of foul aids from leftover food in a plastic storage container. Now, there's no evidence that the amount of families that leach out of plastic storage containers is toxic to humans. That's how they get away with that crap it is. That's how they've gotten away with it. And it's the it's the The indoor and just read the science indoor air pollution is much worse than outdoor air pollution in most areas of the country. Because we don't think about our homes we don't think about the formaldehyde, the benzene, trichloroethylene that we're inhaling, then you go to my book and there's the study with the graph that the study from NASA that shows to six inch house plants, and there's the list of all the house plants that do it to six inch house plants and a 10 by 10 room absorbs up to 70% of the toxic chemicals in the air.Ken Brown 1:05:37 warmer times. This is the front so now you're scaring the snot out of me, but now you're giving me a solution. So you're saying when your book can gotDr. Tom O'Brian 1:05:43 a Kleenex, hand him a Kleenex to get the snot and to six inch houseplants, and there's about 12 or 14 different types of houseplans six inch houseplants absorbable To 70% of the toxins in the air in a 10 by 10 room, they're absorbed through the leaves, they go down into the roots, the microbiome of the soil breaks that stuff down. They produce oxygen and put oxygen into the air to 10 by 10 to six inch houseplants for a 10. By 10 roomEric Rieger 1:06:17 solution.Ken Brown 1:06:18 Yeah, it's a solution I'm all about so and so your book is not just teaching people what to worry about, but you're like, this is the solution. So the one hour a week is I'm going to give you one hour a week solution. And if you continually do that, by the end, you're going to be a healthier person.Dr. Tom O'Brian 1:06:35 You know, everybody wants solutions. Nobody wants to hear about the problem. But there's no way you will have the tenacity to do this. And at a pace that you can do it and not be overwhelmed. That's why it's one hour a week understanding. You are going to be overwhelmed, but you're going to do bite sized pieces pieces of this. And in six months. You've got it. You've changed your life. Your husband Using the Tupperware containers to store nails in the garage, right? I mean, you've got all the the dishwasher, you'd never run the dishwasher during the day. Because the toxic chemicals that come out of the dishwashing detergent, when they get heated up to 160 - 170 degrees, they leach out of dishwashers are not airtight. They're watertight, they're not airtight, and those chemicals are in the air, you're sucking those fumes. You only run the dishwasher at night when everybody's sleeping. And you've got to learn all these little things because the paradigm that we've accepted the prevailing dogma that we've accepted about the way to live life and about our homes is killing us. It's slowly killing us. This is why your patients are coming in with more confusing results is because they're loaded full of all of these toxic chemicals. How many of us have been watching the chem trails? For years to say, Oh, that's really something you know that that's too bad. Yeah, I wonder what that stuff is. And we've never done anything about it. We're sucking the fumes of all those heavy metals that were being spewed into the air.Eric Rieger 1:08:12 Yeah, well, I do want to add something here. I know that we've been it didn't seem like until just looked. But we've been talking for a good while. And I need to also give you some praise since you were the first to utilize the digital internet to reach so many people. You also have one of the most kick ass URLs I've ever seen. Yeah, so what is it? We do? SoKen Brown 1:08:34 we haven't ever joked about this? I was like, how in the heck did that guy get that URL?Dr. Tom O'Brian 1:08:39 1996Eric Rieger 1:08:42 the URL to link up with this very Dr. Tom O'Brien is the doctor.com and I want to say that one more time the doctor.com but you have the Dr. Yeah, I'm sorry. Yeah, you're the Dr. calm. So Dr. Bri ER doctor abbreviated v dr.com. dr.com will connect you with Dr. Tom O'Brien. But you also also have two specific programs for our listeners. One is to do that with a / betrayal to get on to the train of exactly the training that you're talking about and the other one, and I'll put, I'll put this in show notes, everyone, but the other one is thedoctor.com/kickstart. And if you want to do a quick rundown on exactly what kickstart is, that way, everyone in our universe can hop over and learn a little bit more from that from that with from you. Just tell us a little about thedoctor.com/kickstart.Dr. Tom O'Brian 1:09:36 You bet that Thank you. The kickstart is a number of handouts for you. They're going to talk about how to detox your house, how to reduce electromagnetic pollution in your house. What are the house plants that will suck up toxins? There's there's a handout for the kitchen there's a handout for the bathroom. There's a handout for the bedroom, all a number of different handouts so that you've got Steps to implement right away and you take them at your own pace, you'll get the plastic storage containers out of there, order glass storage containers, things like that.Ken Brown 1:10:10 Dr. Tom, I want to interrupt you real quick because you've hit a nerve with me here this is I just don't have the I'm always I spent a lot more than just an hour a week. But I spent an hours a week looking at the stuff that I'm interested in. And I have a blind eye to what you're talking about. And what you just said is I'm going to give you solutions. You can put a handout up, you're just going to go do this, this and this, because I believe you and I, I don't want to read a whole book about why I should get rid of my plastic just Just tell me how to how to fix it. That's what I like. kickstart seems like a really cool program for that.Dr. Tom O'Brian 1:10:46 Oh, thank you very much. And if you were my patient, I'd be all over you. That you can't do that because it's wanting solutions that has gotten us into trouble. Oh, gotta understand. All of you. The map of what happensKen Brown 1:11:01 this where you start yelling at me like you did on stage.Dr. Tom O'Brian 1:11:06 Because if you don't understand that mold can be a huge problem for Mrs. patient. When you go on vacation for a week or two, when you come home, you have to open the windows to air the house out. Oh, yeah, you got mold. You have to have the house remediated, you have to have a professional come Well, I don't have a problem. When I'm here. I don't feel anything. It doesn't matter if you feel it or not. If you're inhaling it, it's going up to your brain. And it's the number one trigger for the development of Alzheimer's is in halation, Alzheimer's, it's what you're breathing. So if your brain ain't cooking the way it should be, it's cooking in the wrong direction, you're too much on fire. You have to identify where it's coming from so you can get all the house plants you want. But if you still got mold in your bathroom, well it's not too bad on the tiles there. You know, it's just on the grout in between the tile that's not too bad. We'll Put that on your tombstone. It wasn't too bad. You know, it's critically important that we change our paradigm so that we understand what our individual map is, what has gotten us to where we are, because that map is going to change, you're going to get better because you implement the things in the handouts. That's great, you're going to get better. But a year from now, two years from no

#Ep.17/2020 - Normalização, construtores e gerenciadores de referências

Plurissaberes

Play Episode Listen Later Jun 20, 2020 9:39

Neste episódio, a bibliotecária Juliana Lima traz alguns aspectos introdutórios sobre os construtores e gerenciadores de referências visando simplificar a normalização de trabalhos acadêmicos. Esse áudio faz parte de um dos módulos do minicurso 'Gerenciando referências com o Mendeley', ministrado a distância pela equipe de bibliotecárias e bibliotecários do Sistema de Bibliotecas da UFC. Ao lado de Edvander Pires e Izabel Lima, Juliana é Mendeley Advisor na UFC, e em junho deste ano foi reconhecida pelo seu trabalho no blog do próprio Mendeley como a Advisor do mês: https://blog.mendeley.com/2020/06/04/advisor-of-the-month-juliana-soares-lima

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#05 Programa Minuto da Biblioteca - Gerenciadores de referência

Minuto da Biblioteca

Play Episode Listen Later Jun 8, 2020 1:58

Conheça os principais gerenciadores de referência: Mendeley, EndNote e Zotero.

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COVID-19 Files: Ep. 6.0

Play Episode Listen Later May 28, 2020 48:48

Welcome, everyone. It is now time for COVID Episode 6.0. We have an incredible special guest this time, of course, I'm Eric Rieger with your host, Dr. Kenneth Brown. But today, we have Aubrey Levitt. She is the CEO of Postbiotics Plus. She's very much into research and an incredible entrepreneur certainly knows a lot of the people in the scientific community that have inspired Ken and I to dig deeper to look further. Without further ado, Ken would you like to say hello to Aubrey, and we'll get started.So you can imagine my excitement when I found somebody that was discussing postbiotics also. So Aubrey, thank you so much for coming in. Eric, do we have any...we need to shout out to our sponsors real quick? No, we don't have to do that. We just did that. You're all you're all here.So Aubrey Levitt. Oh my goodness. This is so cool. I felt like I was alone on an island discussing post biotics and then I have this little routine. I'm a very routine type person. I like to work out and go to the sauna. And I do a little mindfulness meditation. And then I just kind of scroll for the last little 10 minutes on podcasts and I just typed in postbiotics and I couldn't believe it. The CEO of postbiotics plus I'm like, not only does she know about it, she's an entrepreneur. She's smart. And she's got like, and then I went to your website, I'm like, she's got like six PhDs working for her like, holy cow, we have got to track this woman down. So I apologize that I stalked you. But thank you so much for coming on the show.No I was so happy about that. It's so nice to have somebody else on this island with me. Yeah, we put our stake in the ground like postbiotics and then echoes for a couple years, just looking back but no, it's very...So we're calling this COVID episode 6.0 because although we're gonna talk about the microbiome I want to let you in on something that you're doing. So congratulations to you and your desire to go through science first, hire these PhDs make something effective because you're going to change the world like I believe that we're helping to change the world. A article just came out this month, discussing the gut, the actual title is this gut microbiota and COVID-19 possible link and implications. And then another one just came out that said a comprehensive review on the effect of plant metabolites on Coronavirus. Plant metabolites means postbiotics and then somebody that we will get you in contact with is a PhD that we're working with her name is Silvia Molino, she did it to get her PhD. Her postdoctoral study is so cool. She actually looked at invitro digestion and fermentation of stable polyphenols. So she was able to do an in and of course, invitro means in a lab. So she was able to show the postbiotic effect once through digestion and then once the microbiome comes in contact with it. Absolutely brilliant and so cool. So COVID you're making a difference!Yeah. All across the board. No, yeah, I just want to say that one of the things that started this fascination for me was you just look at fermented foods, right, which are full of postbiotics and how much of a role they have played in every culture. And we may not have known why in the past, but when we're looking through the lens of the microbiome, we can see maybe a deeper into what's happening here. You know, I know people know probiotics and they know prebiotics of fiber. But when the probiotics eat the prebiotics, then this magic happens. And that's what's also happening in your gut, right if you have all those elements working.Yeah, totally.And I think why and what I've seen also why it directly relates to COVID is, you know, people are getting are at risk for secondary infections. And also people are getting antibiotics and whatnot. And that directly destroys the microbiome as we know, which leaves them vulnerable to being populated by whatever's there. And, and weakens them.If I'm knowing that kind of research and listening to the PhDs while y'all are constructing the studies, and or the clinical trials to find out what is actually going to work. What are some of the endpoint measures that you that some of your PhDs are examining? Is it because they're looking for what the bacteria will do with the things that you present like postbiotics, as you mentioned before, and how do you measure that, is it like short chain fatty acid stuff or what...We were looking specifically at one thing and just diversity overall, so we were looking at a point of injury. So the one because we wanted to kind of pare it down to. Okay, we know, we're researching the microbiome, and we're looking all these various things, but it's a complex ecosystem, right. And the one thing we do know is that when there is a lot of diversity that always correlates with health. And so we really pared it back to that of okay, but in our modern lifestyle, we have many, many things that affect that diversity and really, you know, strip it. So we looked at antibiotics first in our first study to say antibiotics is one of the harshest things that wipe out gut diversity and leave us susceptible in this window afterwards to either an opportunistic, you know, pathogen taking over or maybe just not recovering to the diversity that we had before. And so we did a study our initial study was to look at these antibiotics because think about it, also, people are coming in for maybe a sinusitis. So having their gut wiped out is a, you know, side effect that is not intended. It's a consequence that's not intended. So we gave them a fermented herbal product, which is full of postbiotics, because essentially, we put probiotic bacteria with the herbal components and it's breaking them down with we gave them that with some live probiotics as well. And we had a control group and we we took their stool samples to see if we are protecting their diversity. So right when they got the treatment, and then you know, all throughout the treatment and 10 days after, and we saw Yeah, so the endpoint was gut diversity is looking to see if the ecosystem was intact.I couldn't agree more and Brown we've talked about this in the past. And of course, we've seen this in the hospital. Oftentimes when people are given really powerful antibiotics and they come to the hospital. Unfortunately, the end result is often c diff, and it's exactly what it does. It goes through it wipes out all of the bacteria we and it tears down all c diff is all that's left in incredible diarrhea which persists forever so that you're certainly speaking I think that bringing up c diff is probably the most extreme version of lack of diversity because you wipe out everything but one particular bacteria that then populates so it's almost like having a neighborhood where only one family dominates and they decide what happens well c-diff kills people. It's very serious. I'm a huge as a, as a gastroenterologist, I reluctantly ever try to put anybody on antibiotics and I see So my research was in bacterial overgrowth SIBO, which is, which is a consequence of antibiotics all the time. My classic patient would be somebody that said, I got a sinusitis just like you said, five years ago, took this big round of antibiotics and I've never been right since. And that's that's the patient comes to me as a gastroenterologist.Yeah. And I was that patient because when I was a kid, I had antibiotics probably every week for years and then I had to go in and have two weeks straight of antibiotics, because I punctured a lung. And so they put you on IV antibiotics. And you know, ever since then it was just sort of this imbalance that couldn't get. I couldn't figure out how to right. And I didn't even know because that was sort of so early on. It was just this uphill battle that I wasn't aware of. So that was one of the things behind of like, you know, I could do everything perfect, but the moment too much stress would come on or whatever else would happen, I would fall back on my resiliency wasn't there, the normal resiliency that you would think you would have.So I could talk postbiotics all day, but now you just got me super intrigued about Aubrey Levitt. And how I built this, how does a woman this powerhouse CEO doing this? You just said you essentially had a very traumatic childhood, what was going on?Well, you know, it's a bit of a layered story, but it was I think it started also with this more, you know, trauma when I was a baby of someone had broken in and I actually had a memory of it, which is even weirder, you know, with a gun, but it put me on this hyper vigilant, very stressful response for years after where I was watching the window and the door couldn't sleep. And you know, this leads to an increase in illness where I was having strep throat probably every week. And I'm only putting these pieces together now actually looking backwards retrospectively, but you have these series of illnesses that which lead to pneumonia and then lead to puncturing a lung. And this is all pre second grade, you know, that happened in second grade. So you're on, you know, just a massive amounts of medication, and not compared to maybe some to what some other kids are having, but it was a lot for me at the time.I mean, I would argue that getting antibiotics that often could be one of the most traumatic things that somebody could do because you will never be able to rebuild this microbiome.Yeah, it becomes and then you only realize later how much it's really affecting you. It throws off your hormones, it throws off your immune system throws off, you know, all sorts of things that were just out of whack with without a real explanation. You know, you'd go to see these various doctors and they couldn't pinpoint what was the root cause.Wow, how are your parents through this whole process?You know, I don't think anybody thought anything of it at the time, right? They were actually very healthy and very conscious of all these things and did their best. But, you know, what are you going to do when your kid has 104 fever every other week? Right? I mean, you just don't really have a choice.Yeah. Wow. And that is wild. So I would, I would even couple that did on top of that. On top of the biodiversity that's being eliminated through long term antibiotics, you've also got, I mean, the stress of anxiety, which is obviously something that you're referencing, if you're staring at a door or window as a young kiddo, and it persists for days. I mean, the time to repair is constantly being thwarted by your body's vigilant state of trying to always be in fight or flight, there is no repair time. That's pretty wild.Yeah, and I don't think people realize how much stress wears on their, their immune system and their body and just like you're saying, it doesn't give you that rest and digest time to recover, which is very essential, you know, to bounce back. So. And I think also that got me very interested in like the gut brain response and how that vagus nerve talks between the two because you're just always reacting. Right?Okay, so we're both smiling because this is just right up Ken's ally. This is exactly whatI just think it's hilarious. This is the first time that we've actually talked. And you're literally mimicking everything that we say. We are a kindred spirit here. We've been on the same island...studying the same stuff.Yeah, exactly. And so, you know, even when we when I created this first product, I think one of the issues that I was finding is that okay, I would take these herbal remedies, I would, you know, eat these great foods, but I still wasn't able to digest them properly or really utilize them properly. And because I wasn't seeing the results I wanted and when I fermented these herbs, what what was very interesting is I actually even felt a focus and a mood difference right away, which is how I got into this post biotic work because I thought, wow, they're like, I think there's GABA or something in here that is different than what was in here when you started with the original product.So you felt it almost immediately.Yeah, I did, I did. And I felt the difference. And so then I went and tested and that there was GABA in it. And also too, if I was actually feeling that and because it was a small amount, I mean and I can't be sure that's just a assumption on my part, but that got me really interested. I started talking to these guys out of corp, you know, Ted Dinin, and they were studying this essentially how the gut communicates to the brain through the signaling molecules and these neurotransmitters that are released through this fermentation process, even if it's in your gut. And so I just went down this rabbit hole and ended up partnering with the scientists out of Memorial Sloan Kettering. Now he's at NYU, who, who was also interested in the same thing of these metabolites. And not only they also signal to the other bacteria in your gut, so there's just this constant communication going on between everything. Not not to get too in the weeds,No, totally because this perfect, this is the conversation I have with my patients all the time, is when pharmaceutical companies and I'm not putting them on blast, but when pharmaceutical companies try and do something they tend to focus on on a molecule that they can patent. And what we're learning is that the microbiome is way too complex, where we're at right now with our, with our research, so you can do these giant stool studies. And so I get all these people that come from functional medicine doctors with these, these gi DNA analysis, and they're like, Yeah, do something like that we can do the test, you don't really know how to manipulate 100 trillion bacteria. Exactly. And so what I tell everybody is, we do know that if you can diversify, they will figure it out. Meaning they when you have a proper diversification, a proper signaling mechanism where they will keep control of each other, and they send signals to your brain, we now know Eric and I did a whole episode just on the negative effects of short chain fatty acids, when they're out of proportion, meaning butyrate being real good. But yeah, if you have too much acetate, if you have too much propionic acid out of proportion, that crosses the blood brain barrier and creates that that gut brain situation. So it's all about just let your body let those microbiome, figure it out. We're not going to out think them.Yeah. And that's, that's also something that really excites me about this whole field is the ecosystem approach, I think is really an opportunity to look at medicine differently than how we've been looking in the at in the past, like this lock and key approach is doesn't work as you're saying. It's sort of the it's very complex, it requires more systems medicine approach of looking at how, if you touch this point, it affects this whole area around it. And I think it's also to me, the one area that's speaking to all different fields, you know, it's speaking to Western medicine, allopathic medicine, speaking to functional medicine, and it's kind of everybody because we don't know exactly what's happening here. But we all agree, it's important, and we all agree it matters. And that that hasn't really happened before. I mean, you guys are the you're the doctor, so maybe you could speak to that more but that's, that's what I see happening. And it's also saying we can't outsmart it. We have to work with it.Yeah. And that's where the whole, that's where I got really interested in the whole postbiotic thing because that's when I started doing. We started realizing that when, when you start decreasing the inflammatory response in the body by eating a different type of diet, I start asking why. And then that's when I started meeting scientists that said, Oh, it's because you're producing, urolithin or you're producing, you know, now a GABA. I didn't realize the GABA. So that's what's so fascinating. So I'm a doctor. And I imagine you've got what six or seven PhDs that you're in this postbiotic thing. What is how did you end up you were sick and then then you sort of jump forward and said, then I started this company. How did we get from there to here?Yeah, God, it's been a windy road. So I you know, I was a, how do I say this? So i i got obsessed with the science part because I always do have to measure and kind of look at...okay, starting with an idea of something that I may feel in myself or that matters to me, but I wanted to look at, okay, how can we measure this in a larger population? Like, it's not enough for me to I didn't want to go out there and just create a product and see what happens? And I guess Okay, so one step back, I do have a background in pharmaceutical advertising and marketing or whatnot. And so it started there. And I was working those jobs and I thought, okay, I, this is not what I'm going to look back 40 years from now and be happy with what I created. I wanted to go out there and solve a problem. And then once you create that solution, then I have to go back and measure and make sure it works. So that's what led me down the science path. And it just it wasn't necessarily the intention of starting a company. It was always coming from solving a problem and wanting to find the answer that didn't already exist. And if you're looking for an answer that doesn't already exist, then you have to test that answer multiple times before you go out there and offer it to somebody else. So, that's sort of the windy road there, I guess.Well, I'll tell you what that is, is that's you've when we you've said several times, allopathic and naturopathic boy, if there's ever anybody who I would not believe would somebody with a marketing background in pharmaceuticals that came up with a novel idea, usually its market first we'll worry about the science later. We're going to make cash on this thing. I've gotten a lot of flack for that. No, not flack at all. I'm giving you so much props you lead with science first. I mean, that is amazing. Especially because you come from a marketing background, holy cow.But to me the best marketing is truth and honesty. Right? And that speaks for itself. And so I was not interested in this...okay, you have this end product and you put a shiny package on it, and you hand it over somebody it's like how many of the layers can peel away so that you really have a clear understanding of where something starts and what the thought process is behind it and you and you just communicate that clearly at the end of it. And that's that's where I think things are going even on a marketing standpoint, but he you're just telling a clear story of why you did it and then what it is and why it works.I could not agree more I think the most stable marketing is knowing that your story is true, can be proven, can be reproducible. Generally, those who just flash in the pan the the charlatans are always revealed over time and then it's just it's just a trend or a fad that fades away but what you're doing is very much in line with what what drew me to work with Ken it's this is what I believe we'll figure out how to tell people about it later, but this is what's working and that made a lot of sense to me.And and even if it does, if it works the other way, do you is that something you really want to be a part of or like is that like I would lose interest over time. So doing it for me more than anything. And then I had to turn around and be like, okay, now how do I find a business story around that that other people get behind? Because I want to do the science for me, because that's what I need to move forward. So it really came from that place, read more than anything else. And to say, Okay, how do I get scientists that are smarter than me that are gonna think they're gonna challenge me? And then we're going to do the research around it and find some answers.There's so much similarity here. You being a CEO now, I had no business background, and now I'm in the throes of essentially, you know, I mean, it's a five year startup and I realized that Apple was a 20 year startup and Right, exactly 20 year startup and all this other stuff. So you you get that that side of it. I was super impressed with your team. I mean, you are just filled with PhDs and a couple MDs.Yeah, yeah, we got really lucky of and at this point, everybody's kind of donating their time. Like they've got on board out of passion. And that's what I think is even more exciting is that they believed in the process and we just kind of found scientists that were really obsessed with what they call this ecosystem science and looking at how these interactions happen in the microbiome. And I love the idea of ecosystem science that encompasses so much and it actually flies in the face of what Ken and I both kind of find challenging with, unfortunately, the pharmaceutical world which is just trying to find that one little bitty active molecule to try to solve all of the issues with that because it doesn't generally work that way. That being said, what are the goals with the company and utilizing ecosystem science? Where do y'all want to go? What what is what are some some pinnacle finish lines for y'all?Yeah, I mean, what's so there's two things that we have really exciting on the horizon and one we we are working now. We just talked to a doctor at Memorial Sloan Kettering and what the research they've done at Memorial Sloan Kettering is a cancer hospital. And they really looked at how diversity affects cancer patients. And that's been something that was, you know, a long term almost impossible thing for me and and the fact that we're actually pursuing being able to do that is exciting. And what they found is that so they did some FMT studies there. And they really found that if a patient comes in and they have higher diversity, then you know, when they go through their chemotherapy, and then their antibiotics and the most severe treatments, for the third, specifically working with bone marrow transplant patients, the patients who have the higher gut diversity do better. They surv...they're more likely to survive, it actually affects survival rate, and it reduces complications. And so this has sent them down the path of really looking into what can they do to protect the gut diversity and help these patients and so one of the questions they asked which I found fascinating is okay when you receive high doses of chemotherapy and antibiotics is there really anything you can do, or is your gut so destroyed at that point that it doesn't matter? And what they found was actually even a little bit helps these patients and helps their survival rate. And what that means is even if there's no intervention, so they may just happen to be someone who bounces back better than somebody else. And so, and they bounce back to a just slightly higher level than the other patients whose guts destroyed that slight increase in diversity, they do better. So that means even if they eat a better diet, they're potentially going to do better, which is to me huge because you can come in with something that is a more dietary or intervention and improve their outcomes. And so again...Very, very interesting and very congruent, Brown, with what, what you've been talking about even back to the inception of Atrantil. We, we have what we think are these incredible polyphenols this polyphenolic blend to feed bacteria. But, you know, the opposite needs to be true. Also, if if the correct bacteria aren't there to be fed in the right ratios, then we're just not going to have the byproducts, the postbiotics that we need for the body.Yeah. So Aubrey, so I'm sitting here listening to you, and I'm thinking, okay, so we talk about bio diversity and all this stuff. But the reality is, is that the bio diversity leads to this complex cascade of things that happen. Yes. And if I've got in my world, gastroenterology, I've got patients that have their colons taken out due to ulcerative colitis, due to cancer, due to different things. And we've actually talked, we've got one of my graduate students, actually, Angie will be very excited to know that you came on. I've got a graduate student that Eric and I work with carefully, and we started discussing this that well, what happens nobody's talking about If you don't have your microbiome, how can you make sure they have sufficient amounts of butyric acid? How can you make sure that there's urolithic come out there? How can you make sure that now Gaba and now we know that are they getting the appropriate amount of vitamin K, are they getting the glutathione things that we know that the bacteria break down, nobody's talking about that. And the ability to say, okay, during this acute process of getting chemotherapy, I would almost think that your particular product should be the protocol to ensure that there is something.Well, and that's what I think we got passionate about if there's nothing done to support the body to recover better when certain treatments or therapies are given and why not. So it's, you know, I mean, I think it brings me back a little bit to this COVID situation, what what's your best defense, your immune system, your own body, you know, and I think that no matter what you have, no matter what treatment you're given, your own body's going to be doing some of the legwork to get you back to where you want to be, or at least even to be able to handle the treatment better because a lot of these treatments are so harsh that they're also taking a toll on your own immune system or your own body in various ways. So, and we're not doing anything to help mitigate that or support the body as it's recovering. And that seems like an easy place to intervene and have because it's, it's gonna fall back on that on your body anyway.You know, I'm sitting there thinking about you as a young girl looking out the window, being hyper vigilant with the sympathetic nervous system, and then I'm thinking about a cancer patient that wakes up and goes, oh, shit, I have cancer. That thought sympathetic nervous system goes up. Exactly. Then a nurse comes in says, Remember you have chemo. Oh my God, I'm gonna have diarrhea, and nausea and vomiting. And I mean, you cannot think of a worse scenario, then and my, I mean, we've treated a ton of cancer, and the thought of the sympathetic nervous system going overboard the worries that are going on the financial stress, all this other stuff, it's very similar to the COVID situation. So similar,And that's our lifestyle these days, is this a high, heightened, stressful situation is we're constantly under stress. And so, and I think why, until you get something more severe, a lot of times, we're not thinking of what the effects of this are. But really the goal would be anytime you're sort of hitting a heightened stress, how do you balance that with also protecting yourself? And we're not really ingrained to think that way yet. You know, because it's having one round of antibiotics, we should be doing something to build ourselves back up to protect our gut microbiome. So that's why we looked into that in the study of like, how do you protect the diversity and make yourself and help yourself bounce back, right? Because that directly affects your immune system, which is suppressed during that medication and it's going to need to bounce back, you know, the microbiome helps with that. So that should be when you're in a stressful period when you get you know, because then we may not have it cascade into these larger problems, we start looking at it early. But then again, when you have the most extreme problem even then it helps you bounce back. And I, I just keep seeing this also vision in my head of the COVID situation of what happens when the whole world takes a break for a little bit. You saw how even like nature bounced back so quickly, right? Like the amount that we can all bounce back is actually incredible. If you just give a little bit of help...for a second.And I love how you're saying that because there's I have so many patients that when they they do something that let's say that they are...well, we've seen this. So Eric and I, we've we launched a program, Aubrey that we call the frontline program, because we believe so strongly that gut health, you cannot have a healthy immune system without a healthy gut. Because health begins there. And so we have launched a program where we're just giving away Atrantil because I know that it increases diversity. I know that it actually has anti pathogenic activity. I know this and we discussed it as a company, that we have a moral obligation to at least help the people that I'm with like I could, the thought that I could go to my hospital and find a nurse that maybe, you know, if somebody died, that maybe we could have just given them something to help, then that, that really that that drive starts getting me thinking about all the stuff that you're talking about, which is like, why can't we start doing protocols at a hospital that are essentially harmless, which is what you're talking about. There, the risk to benefit ratio, and it's insane the hurdles you have to go through. Like you had to find somebody at Memorial Sloan Kettering, you had to sit down, you had to go through meeting after meeting after meeting he had to then get passionate enough to go to the IRB to go to that. I mean, I've been there. And you're like, for God's sakes! Right. I mean, we're on the cardiac floor. The cardiac diet is pancakes and syrup and...Right, right. Yeah. I in and it's, it's kind of like Why not? You know, it's as you're saying it's why not do something that is going to do now it may help it may not in some situations, but why not?Yeah, we're going so far as we're giving away. I mean, we're losing a ton of money doing this just trying to make sure that if it does, if it can help, and we learned that it helps later, then I would look back at myself at this time and go you're a jerk for not at least trying to tell people. That's really great. That's really great.But it brings a question to my mind, Aubrey with your PhDs and we kind of set the stage here a little bit. So medicine in its early day was all it's all predicated. All the information we have is predicated on people doing experiments it's how we, we came to find everything and then ultimately which seemed like that we're at this intersection where innovation which might occur outside of, you know, the small little nucleus of companies or a handful of doctors is just summarily rejected until finally, over time, it's finally accepted because it happens to work for for someone else, or it's disproven and it doesn't work at all. But what inspires your PhDs to work with a company that's essentially helping challenge the status quo by using natural solutions? Because I know what works for Ken and I, it's because we see people smile and get real relief after trying for so long. So that's an easy one. But what is it about the PhD at that level who's like, you know what, I'm going to go to work today and keep challenging this because why?You know, that's great question. So I think a couple things I do think the microbiome has really opened the door to it's almost looking at it through the lens of the microbiome being complex, and not necessarily as much what the input is, because when you're looking at postbiotics, it kind of takes it one step away from like whether it starts as a natural product or not. I also think this next generation of scientists is they're very, the ones I'm meeting now are very interested in how can I make a difference? How can I not just stay in the lab? And how can I put something into the world and see that research be realized? And I think I happen to meet scientists that were passionate about, okay, this approach of taking the one missing bacteria, or this group of missing bacteria is not going to work. And they were willing to kind of stand on the edge and say that and my co founder who I work directly with, he did some research in Japan and you know, overseas, so I think it really opened up his eyes to hey, there are these things that have been studied for a long period of time that have been used with patients, but it just wasn't under a scientific rigor. So what happens if we look at that information and we start putting it under the lens that we look at other scientific remedies, what will we find? And it's more of just an openness to asking that question, and not really saying, okay, let's pick something more natural. It's more just like, okay, let's open our door to this wider range of things, whether it's natural or not. Let's look at what works.You know, I love how you say that. Let's open the door. Because what I've run into, which I'm sure you have run into, is what I I call cognitive dissonance. If somebody believes something, and they don't want to think about anything else, you described it as opening the door, just look outside and see and keep an open mind about that. That's really cool that you found people like that because when you get up a team, one thing that has been really neat about this whole COVID-19 issue is the collaboration of the scientists around the world. People are running with...people are just sharing data. And they're just saying, hey here, just what can you do with this? And this is, I think that the collaboration that's going on right now with you and your team is so cool, because this whole idea of opening the door and saying natural solutions and what is natural the most, you almost it has this implication that, oh, I'm going to try something unusual. And what you're saying is no, we're going to use our body and we're just going to feed it what it wants and allow the bacteria to do what they do, which is the most basic fundamental thing you can do for your health. I love that.And it's also not looking at the two extremes, right? I think, you know, just because something's natural doesn't mean it's healthy either. I think that's that's pretty clear as well, I you know, that there's, we can't jump to an extreme on either side of this. It's like okay, we can have a wider array of what we're looking at to support the body and then we test it and that's it. So what got the scientists I'm working with fully on board was our first study, we had a control group and we had results that were surprising to all of us because we went in saying, we don't know, maybe this could work. And then we got the results from the first study. So that's really what sealed the deal. Not not any kind of hope around it. Right?Yeah. Let me pin you down a little more. I know that Eric poked you a little bit here. But I'm going to take you one step further. So well, I want to know the because I'm, I'm much like you I'm into the science, but also own a company. And so I'm curious where Aubrey sees the business side of this. Where do you see that going? And you already said that science. You're correct. You're helping people. So morally, you're on the right place, but you also have to pay these six PhDs you also have and, and the beauty of having a successful company is that you can hire more people, more people can can can get insurance more people can, you know, there's nothing wrong with taking a beautiful scientific idea and turning it into a successful company.Yeah, yeah. And I and I tend to think of I prefer building a company where maybe there's a bigger hurdle upfront. And then hopefully, once you get over that, you're gonna have an easier time rather than sort of getting out the gate and meaning if you do the science, you get the credibility and you'll get people behind me and that could be your marketing that you go out the gate with. So what we're hoping is to get this next study done, which we hope we can get this study done with these cancer patients, which is more extreme scenario, right, and then we could put it as a medical food and that would be the hope and then you can also use it as an adjunct when these other medications are given because it's essentially 24% of medications affect your gut microbiome negatively, right. So really want to pay attention to when you're taking these medications, how do you protect it and I think also in these stressful situations, so the idea would be to get it as a medical food and then also take it when you take antibiotics and other things. And so it's not kind of it's when you need it right now like an ongoing every day sort of thing.Well, I see it as a not to have death by 1000 cuts, because I'm seeing going to my company, digestive health associates of Texas, I think that you have a relationship to Dr. Rogoff, one of my partners.Yep. Don't you?Yes, I do. He's a great guy. Yes.So we've got a Research Division that does pharmaceutical research. My background was in pharmaceutical research. That's how I went from that's how I discovered a a hole that they were missing and that a natural solution could fail. And that's very similar to what you did pharmaceutical marketing. Well, it would be really interesting that you got me thinking that I'm like, wow, we could easily do an inflammatory bowel disease study. And people that have had colectomies and see how they feel just a quality of life scale something super easy. Now you really got me thinking like, are they? Are they living their life with one hand tied behind their back? Because we took out their colons?Yeah, yeah. Yeah, no, that would be that would be very interesting to do. I would love to do that. And I think, you know, here's the other side of it if we find something really interesting in one of these studies too to be able to take a collection of metabolites to say to really look at what are what are the predominant ones that are sort of the this lever for the inflammatory or the immune response is is a way to go, you know, because I think we can dig even deeper into so my interest is not looking at okay, these bacteria are the ones that are responsible but which metabolites are responsible in which collection metabolites that can potentially trigger the system?Yeah, fascinating that you say that because I've met with scientists that are actually working for pharmaceutical companies trying to get the one metabolite. And they're trying to get the patent on that. And I just laugh because I'm like, so you get this so does it survive in the gastrointestinal tract? Does it is it the actual one that the bacteria can you have, like we talked about on our show, Eric, you can have too much of a good thing. Your everything has to be in balance. Eric frequently will hyperventilate when I work with him because he thinks that air is good for him, and he'll just do too much. He doesn't do that.One time I realized that shoes made my feet more comfortable. So I just I just covered myself in shoes. Really, really bizarre. Well, hey, I think that, undoubtedly and away from even just this, this, this COVID interview that it's obvious that we could find some synergy between efforts, but for everybody who's listening, anybody else who's interested in postbiotics plus, how can someone else become involved, get in touch with and possibly even help you find what your goals are as well?Yeah, I think the easiest way is the websites postbioticsplus.com and send an email through there and anybody that's interested in helping us move this research forward, that's that's sort of our biggest goal right now or yeah, that's that's the easiest way to do it. I think we're trying to do it in an organized way with a formal study and then we'll go from there, soWe will try our best to do that I have an ask of you though.What...oh noThere's gives and asks, I don't remember his name, but you've got some badass person at Baylor that's head of virology and micrology, microbiology on I saw that on your team on his page. I would love to get in touch...Oh Joseph. Yeah, okay. Okay. Yeah.You've got, I mean, from an academic standpoint, you've got a pretty heavy hitter page. That was a...We've got a good group.Yeah, I mean, like, I'm a I'm a nerd through and through. And so I was like, oh my gosh, look at this. Oh, yeah. And I start looking at the research. I'm like, oh my gosh.Yes, yes, we can. We can make that happen. We can make it, have you talk to him, so...Cool. Cool. That is awesome. Aubrey. For those of y'all who may not know she's the hardest working woman in postbiotics because we're talking on Memorial Day morning. So. Oh, yeah. Thank you so much for doing this. Yeah. Thank you so much for carving out time to visit with us. This was an incredible discovery of synergy between efforts and it's I mean, to me, it's just it's not only a relief, it's exciting to find somebody else who also realizes that there isn't just one solution and to find solutions, it takes a team effort and it's different thanNow we have a club. This is awesome. So so let's start a Facebook group and other things that clubs do I'm not much into social media, but okay, we'll try it. It'll just be awkward staring at each other. Secret handshake.How did this work again? Yeah. Awesome. Thank you guys for having me.I love the work you're doing. Thank you so much for everything Aubrey Levitt postbiotics plus. We're gonna try we're gonna stay in touch. We're going to collaborate like crazy. I've got some scientists you need to meet around the world, some crazy smart people doing very similar things. I'd like to meet some of your scientists, so on and so on. And I don't think that I think that maybe a collaboration between us could probably help out this crisis that we're going through right now eventually. Not in a not in an arrogant way. But yeah, I believe that you see it also that immunity starts in the gut. Yeah, can it can I say one last thing? I know we're, but there's a study. I mean, when you think of collaborating, there's a study. I think it's at Columbia right now that's looking at fiber and inulin, of how it can prevent secondary infections in this COVID thing, and I think there needs to be one in postbiotics of how we can look at.Well, the article that, that that that Sylvia did was really wild because she showed the increase in butyric acid, and it was tenfold. It was 100,000 fold, it was nuts, that I had no idea when you start looking at this where you can actually show this and then we start to I've got this, do you have a Mandalay account, the repository of literature? No.I'll hook you up with this. In fact, we probably team up I've got a I've got an enterprise level Mendeley account where you can just put literature, download literature and put it into files so that you you can search your what you want. So I could like go right now and type in postbiotic you know Sloan Kettering and your your stuff would pop up. It's really it's just it's just a way to collaborate with other scientists that I've really enjoyed so that we can do stuff like this.Great, great. Sounds good.Ladies and gentlemen, that's, that's COVID Episode 6.0 Aubrey Levitt postbioticsplus.com thank you so much for joining us and thanks to our sponsors atrantil.com of course ilovemytummy.com KBMD health and unrefinedbakery.com Aubrey, thank you so much. Ken-any last words?No, thank you so much for taking the time and and on Memorial Day you know not being out on a boat using proper social isolation taking the time to do a podcast. Thank you guys.Have a good one. Bye. Bye.Talk to you soon, bye.Oh, she she jumped out.

56. Readable lab notebook

Researchat.fm

Play Episode Listen Later May 4, 2020 78:51

クモについて詳しいゲストを迎え、フリーハンドで丸と直線を描くトレーニング、メールで進むかまいたちの夜、自作PC、論文管理の難しさ、趣味としてのポッドキャスト、コーディング環境とWet/Dryのデータ管理について話しました。Show notes Readable Lab NotebookのTipsを集めたいので、ご協力いただける方はtwitterにつぶやいていただくか(我々が検索可能な形であればうれしいです)、お便りコーナーから連絡いただけると助かります。そのうちまた紹介したいと思います。幻影旅団 HUNTER×HUNTER (Amazon) フリーハンドで丸と直線を書く…デザイナーの山中俊治さんによると、「今でもスケッチを描く前には、初心に返って、一枚の紙を楕円で埋めつくすことから始めます」とのことです。手塚治虫 (Wikipedia) かまいたちの夜ニワンゴ版…JavaとPHPで実装されていたニワンゴトップページ…Internet Archive (2009年)。懐かしい。ちなみにこの頃、ニコニコ動画は Youtube の上にコメントを表示するサービスでした。 Linux Ubuntu AMD Ryzen 7 3700X NVIDIA Tesla V100 32GB GTX 1070 Ti…このあたりがお値段も手頃で良い。 CUDA AWS 光るメモリ…どうだ明るくなったろう。光るキーボード…明るい！ LG 27 inch UltraFine 5K Display Apple Pro Display XDR MacBookProの車輪 MacBookProの脚液浸冷却サーバを丸ごと液体に浸して冷やす「液浸冷却システム」【FUJITSU JOURNAL】…解説があります。ドッキリに使えそう。 MOD PIT 02: The end results (水冷式)…見てると欲しくなりますよね。 EK’s ultimate CPU water block…格好いい。 TSUBAME フロリナート Zotero…論文のPDF管理ソフトのうちの一つ。Nakamuraさんが使っている。 Mendeley GoodNotes…iPadで手書きメモ Blue Microphones Yeti USBマイク Anchor Stand.fm click…Python用のコマンドラインツールを便利に作れるライブラリ jupyter notebook Docker elm…JavaScriptにコンパイルできる関数型プログラミング言語の一つ。リーダブルコード (Amazon) Plasmids 101: How to Name Your Plasmid in 3 Easy Steps…Addgeneにもドンピシャのブログがありました。ぜひ参考に。地球平面協会のウェブサイト…地球平面説は、ガリレオの時代の話が有名ですが、これは現代の話。ビハインド・ザ・カーブー地球平面説ー (Netflix)…地球は平面だと信じる人達を追ったドキュメンタリー。見終わるとモヤッとした気分になります。Nakamuraさん紹介でsohもおすすめ。殺人鬼との対話：テッド・バンディの場合 (Netflix)…多分これのことを言っていたんだと思うNetflix はこの手のサイコパス物が充実していて、他にはピザ配達人爆死事件の番組もおすすめ殺人犯の視聴率 (Netflix)…マナウスで大人気のテレビ番組司会者、ウォレス・ソウザ。彼とクルーは報道番組「カナル・リブレ」を通じて、犯罪撲滅のため日々戦っていた。しかしある日…… ハイパーハードボイルドグルメリポート…ヤバいところに行っヤバイ人と飯を食う番組。ディレクターの上出遼平さんのインタビューも面白い。書籍が出たそうです。 Editorial notes 光るPCはロマンだと思ってます (nakamura) 昼飯作っていて最初らへんの収録に乗り遅れました (soh) 次作るキーボードはめっちゃ光らせるって決めてる(coela) readable lab notebook ほしいなぁ(tadasu)

amazon netflix stand anchor pc ab wikipedia ipads e3 jp python aws 3m linux editorial notebook lg easy steps javascript macbook pro ubuntu cpu ek docker internet archive nakamura cuda gtx amd ryzen 8b e3 goodnotes readable zotero mendeley plasmids 3700x addgene

COVID-19 Files: Ep. 2

Play Episode Listen Later Mar 29, 2020 70:25

Okay, welcome KBMD health fans and gut check project fans, it's time for COVID installment number two. These are the code files where essentially, myself and Dr. Brown, a co host we're going to address the latest in research for coronavirus as it applies to healthcare and our community. Dr. Brown, how are you doing?You know I'm doing is I'm doing well considering the state of how a lot of people are probably struggling through this process. Once again, the COVID files I think you and I really enjoy joking around and stuff, but this is not something that I want to joke around with today. So the show right now we're becoming much more sciency than we've ever been. And it is because I want to make sure that anything we discuss has a reference to it. So let's begin by saying that this is a show and not intended to treat diagnose anyone. I'm a medical doctor. With the current state of anxiety I'm trying to sift through hundreds of articles being published daily because this is a global problem. And I am fortunate enough to have our secret weapon which this week I was on Dr. Chang Raun's in Darrel Hill summit with Dr. Hyman and some other incredible people, Dr. Pompa, Dr. O'Brien and all these people and I, I told them all that Angie Cook is our secret weapon. And then on the CBOE SOS summit yesterday with Chevonne Sarna, I let it drop again. So Angie, thank you so much for working hard and diligently with me to try and get through all of this literature. Cats out of the bag. She is a certified nutritionist and Rn one of the smartest people I've ever met, and she sent me this email right before we went on. Today the numbers are staggering and the stories of what our healthcare workers are facing is heartbreaking. Please be careful. So what we're going to talk about today is mind blowing, to be honest. And I'm just going to be honest. In the sense this is no, this is not opinion. This is not based off of anxiety, or based...this is strictly the science. And this is not the time that I want to, I want to be perceived as I mean, because one of the concerns Eric, you and I've talked about this, I want to shout everything that I've learned from the rooftops, but I don't want to come off as somebody that's saying that I want to try and make money off of this particular crisis. That's not at all what I'm trying to do here. What I'm trying to do is show you the science. So that being said, I've got so much new information. Last time on our COVID one files, we're going to say how we're going to talk about what you can do with lifestyle and supplements. We're still gonna do that. Absolutely. And I actually learned a lot from being on Chang Raun's summit. You can look that up. It's Raun, Chang Raun. Some of his experts are functional medicine experts that understand the supplements better than I do. And I took notes while I was there. And I was a panelist on that. And the stuff that I talked about was really well received by his panelists as well. So everything is a moving target right now. So this is going to be I'm calling it a mic dropping show. Because if I don't get too geeky, and that's your job, Eric makes sure that I don't go into the weeds and be a nerd because I am a nerd to the nth degree. Angie and I have been nerding out crazy, like hair, you know, like reading articles and your hair just stands up because you're like, oh my gosh, there's no way this is here. Nobody else is talking about this. So if I come across here, and you're like, I've never heard of this. I feel like this it's because you're not spending 12 hours a day with the...a beast like Angie and I. She's uploaded over 20,000 articles to our Mendeley account. So I remember Dave Asprey when I listened to one of his podcasts. He's like, let me log into my Mandalay. I'm like, I wonder if his Mendeley is as big as my Mendeley, which is a repository of journal articles. So I'm super excited to get into this show. So that's my initial thoughts. That was my ramble. And I will, I will have everything else will be scientific data from here on out.Well, let's go ahead and start there. So we last on episode one. Basically, we broke down the various aspects of what is coronavirus? How is it directly affecting and we even talked about the stresses on resources. But now on today's show, not only do we want to leave everyone kind of with an idea on what they can do to supplement their own diet and the day to day things that they could be doing to basically improve their immune system as well as basically weather the storm better. Well, let's get a little bit more into the science of what's been some of the more recent data that I know that you and Angie shared because we've we've had a lot of conversations between last show, you going and doing now virtual clinic, me going and having meetings on transitioning the ASC over to possibly new ICU rooms, which is something we've never had to do before. So I'll let you kind of take it away there.Yeah. So you know, this is this is daily. It's hourly changing, let's be honest, and this is a global problem. So there's so many studies coming in what I think that makes us a little bit unique on the gut check project, is what we're doing is we're looking at the the data being published right now. 2020, late March, everything's been published, but then because of trying to link it to the 2003 we are able to look at articles back then also, because the SARS COV-2 virus structurally is extremely similar to the SARS first virus the COV. So a lot of these articles are a transitioning like that, where you can say that this is this and then because of that the links allowed us to find other things. So, a lot of what I'm going to talk about is preprints, meaning that I have access to articles that aren't even in publication yet. But the scientists are so passionate about it, that they're just sending it out. A lot of it comes from China because they have the most experience. I believe that when we did our first COV files last week, I don't know what was their 160,000 cases, something like that. I don't remember.Yeah, they confirmed and that's that's a pretty important thing. So we talked about that last week to confirm just because we're increasing confirm number doesn't necessarily mean Doomsday. It's just that we're able to actually confirm that a number of people actually have it. However, it does become a data point that we need to reconcile with. And we will yeah, we can we can get into that. But I just want to tell you I just looked about an hour ago and right now, the confirmed cases are 577,495. Mm hmm. That has jumped a bunch. There has been 26,447 deaths. I'm getting a lot of emails from healthcare workers who, when these patients are funneled to one institution, like my hospital, that institution, those health care workers are putting themselves on the front line. They are, they are the heroes. They are defending all of us by taking care of this and I just want to say thank you to every healthcare worker that is working shiftwork, that is in hospital, because you are the frontline of this and many times you don't even know if the person you're treating has this extremely virulent virus virulent being very contagious. So thank you. Thank you. Thank you.Yeah, without question. Thank you. Now, I this is not a doomsday podcast at all. In fact, to the contrary, what this is going to be is a complete bright light on this whole viral pandemic. I feel like we have spent this whole time figuring or looking at data and piecing together things that will bring hope to everyone. And that's what this podcast is going to be: how do you actually protect yourself? This is based off science. This is based off a bench research. I understand that some doctors would say, well, we need a randomized placebo control trial. We are not in an era right now where we need to do that. I understand that that is ultimately what we want to do. But in this I just want to protect people with things that we know have been around a long time. It doesn't have a whole lot of downside. So I have a moral obligation to do this and to share it with everyone here.Definitely, without question.All right, so let's let's talk about transmission, some of the newest information that's been learned. So everybody if anybody's new to the show, if anybody's wondering like, Why in the world is gastroenterologist talking about COVID19? Well, everyone's talking about cobit 19. So, doesn't matter if you're human, you're talking about it, but it's actually specifically relevant to me. And some of the newest information is this is that we now realize that the virus can be passed both through droplets in your respiratory system, and it can infect your gastrointestinal system. As it turns out the h2 receptor that we believe the virus attaches to that most have agreed to that the highest concentration is in the stomach and the duodenum which is the first part of your small intestine. So if you are eating food, that somebody has cooked for you or that, or maybe you've well, somebody else has to have cooked it for you, and you eat it, the virus can then get into your body through your gut, we now realize that somewhere between 30 to 48% of the COVID19 cases are actually starting in the gut. And 85% of those present with anorexia, or they're just not hungry. What's fascinating is that when you and I were talking, and we were going over those numbers last week, I was like, why is that and then the very next day, articles have come out and it's made the news now, but we were talking about it last week, about how one of the early signs of this could be Anosmia, which is lack of smell, right? Ageusia which is lack of taste. So my theory is that those people that have that that precedes the symptoms by a long time, or not a long time, we don't really know but it certainly is one of the preceding symptoms. So when I'm walking into my hospital and they have to scan me and see if I have a fever, first question that I'm asking is, how's your sense of smell? Because that is now a screening tool. So keep that in mind. The letter there was a article published from my college, not my college, I went to but the American College of gastroenterology, which is the society that I belong to. There was a report from China reporting that cases with someone who had contact with her brother from Wu Han, so a woman shows up with a fever to a hospital. Her brother had come from Wu Han to stay with her. She gets a fever she shows up says my brother was in Wu Han. I've got this they do a CT on her. And she has the ground glass appearance of the classic COVID19Right.tested negative four times on the sputum. One of the doctors was savvy enough to go test her stool. They did an immediate polymerase chain reaction a PCR. Her stool is positive, her sputum was negative.So the sputum technically you're saying that they the margin, there was a she basically was a false negative, correct?She was a false negative on the swab that they did. They did a total once they got her diagnosed, they knew that they were dealing with COVID19. So then she became sort of a case study where they did like five more swabs on her all negative. So what we're what we're talking about here is that the gut so as a gastroenterologist, I'm telling everyone right now your gut is your first line of defense. And we need to protect that you can do all you can for barrier to avoid droplets to get it in your eyes, your nose and everything. But you still gotta eat and all these people that are ordering takeout and everything. somebody's preparing your food That's a route of admission. And then this is not to create anxiety. This is just so that everybody understands this. And then I found another study, shockingly, that showed that there was viral shedding in the stool. Five weeks after viral shedding in the lung went down. So they recovered from COVID19. And then a group of physicians tracked these patients and they kept checking their stool. Five weeks after being normal, they still had virus in their stool. And on the last show, we did talk about the fact that the virus can live three to four days on steel and plastic, it can live in the air for hours. So if you've got maybe what we're talking about here is fecal oral. And I hate to say that because everybody cringes when I say that, but that's how all gastrointestinal bugs get passed.Well, I think we should address it you know, you're talking about science to layman's terms. So If we're addressing things like, keep your six foot distance, etc, that has a lot to do with the droplet transmission. Everyone's been told and we've learned as children growing older that we should wash your hands after going to the bathroom. But specifically, if you're going to the bathroom and and you've, you've had a bowel movement and you certainly if you've known that you've had exposure to Coronavirus or COVID19 be certain to be diligent about washing your hands after you finish the bathroom, even more so than in the past. So if you've always been washing your hands great, it's now's the time to make certain that you're diligent in the process of washing your hands, keep your hands clean, because the fecal to oral transmission is a real, is a real problem.I got called by a doctor today who wanted my opinion. Very intelligent doctor and he was like, hey, man, what's going on with this? It's it's all hype, whatever and I I started telling him about this kind of stuff. I said, no, it's this is this is real. We all need to...education is the key to controlling your anxiety. Remember that we're not here to cause anxiety. What I'm trying to say is, the more you know about this, the more you can control it. And what what we're going to do is talk about how to protect your gastrointestinal tract. Yesterday in shavon saunas CBOE SOS summit, I discussed how unfortunately, my theory is that if you've got CBOE bacterial overgrowth, or any other gastrointestinal problem in your upper small bowel, you probably have a compromised tight junction that will allow easier penetration. So my job is to let's fortify your gut. Let's make sure that your gut is strong. So when somebody comes knocking, you don't open the door. That's all you have to think of it.Just a quick reset it when he says tight junction is being breached. He's basically talking about the barrier in your GI tract basically, it can become permeable allowing you to become more inflamed or, or ill. So basically he's saying if you have this issue, what we're trying to do is protect it so you don't have that problem.So you're gonna do this a lot for the rest of the show. Basically, I want to say things that because I have been so into the weeds reading just super sciency stufflike what he says when he says into the weeds, he means like he's going to drill it, no I'm just kidding.I just it's just rabbit hole after rabbit hole because you hear a term and you're like, oh my gosh, what is that gonna go down over here and this and that. Alright, so I'm just going to talk about one of the coolest things coming out of Germany is there are some scientists that have a new rapid test to diagnose SARS COV-2 remember SARS. COV-2 is the virus that causes COVID 19. SARS COV-2 is the coronavirus the coronavirus is a family of viruses, this is the ridiculously tough, virulent, you know, bad one that's creating this pandemic. So some brilliant scientists realized that certain flavonoids, or polyphenols have a very high affinity to attach to the SARS COV-2 spike proteins. So you always see that picture of the, of the of the virus they always had it shown with a bunch of those little spikes all over the place. That's how come, Eric, you told me this earlier that's why they call it the corona because it looks like aLooks like a sunburst. That's what it is. That's how I learned it long ago, but it was called Corona because microscopically It looks like a big, big sunburst.Yeah. So normally, the way that these tests are done to try and determine this, what they're talking about is a diffusion test or what's called an agglutination test, but what these researchers showed is that two polyphenols luteolin and quercetin have a very high affinity and an inhibitory effect on the SARS COV 2 virus, I'll say it again, basically natural products, natural molecules in nature have the ability to attach to the virus. And what these guys proposed is that normally, when you have a test like this, you have to have an antigen, which is a protein that the antibody has to buy into or in this case, what you would do is use a very expensive antibody against COV-2. So they're trying to do tests like this, but they're taking blood from people or animals, getting the antibody and then if you put your sample if the antibody attaches, then you know that you've got SARS COV-2. These cats figured out that natural polyphenols attached to it. So what they do is they put the sample in, they put some polyphenols, there luteolin and quercetin and then if it clumps, then they go, that's positive. If it doesn't, then it's just chilling. That's, that's mind blowing.Yeah. So essentially, what you're saying is, is these polyphenols made the SARS COV-2 virus nonreactive. The antibodies had no, they didn't discern it whatsoever. So it was a negative test.No. So what it is, is they didn't necessarily make them reactive or non reactive. All they did is they could show that they surrounded it and smothered it. So when they found this in clumps, they knew that they had SARS COV-2. So this is just a preliminary test to say do you have it or do you don't, you can extrapolate that it can be both diagnostic and therapeutic. Meaning you can look at this and say not only can you diagnose it, but there's a very good chance that this same type of polyphenol may treat the virus. And that's what these researchers basically said in their conclusion. And what's awesome is they said this could probably be done with a lot of other viruses because of the antiviral activity. Soit's very, very interesting diagnostic, I'm almost certain whether it's therapeutic or not remains to be seen. It certainly is a natural compound to, at a minimum run interference for the SARS COV-2 virus.Yes, so you're probably wondering, Well, why in the world did you bring up some obscure tests that isn't even out yet? Because what's awesome is, these are all like preprints. These are scientists sharing stuff around the world. And I can almost follow when one guy references another guy, and then they do a study. The studies that I'm going to talk about in the beginning are all bench research that is called in vitro. When we describe something in vivo it's one we give it to a human. Right now, the virus is so new the novel Coronavirus is so new, that everything has to be done in a lab first to see what could be potentially effective in a human. So keep that in mind because that's that's an argument that a lot of people will say is oh, well, there's no randomized placebo controlled trials on humans blah, blah, blah, we're not we're not we need to stop something first. Need to control this and then we can flatten the curve. Get that R0 watch this, watch the first episode because we get way into the R0 thing get that R0 down, and then we can go there. So, dude, what I'm going to talk about is absolutely nothing short of extraordinary, extraordinary. And these are drugs that President Trump is telling all these private companies. I think there's like last week there was 35 different companies trying to produce products against this. There's a lot of them are called protease inhibitors. A protease inhibitor is an antiviral drug that we, that got discovered during the HIV era, where what they do is they block the virus's ability to grow up. So in other words, a virus tries to release his buddy. And then the protease inhibitor says, nope you're gone, and then they kind of kill the new viruses being produced. This is, and this, this prevents the viral cells from growing and maturing. And according to the scientists that are looking at clinical trials, they're trying different protease inhibitors to block SARS COV-2. So there's clinical trials going on with protease inhibitors that we know So, the first article that I want to talk, this is the title of the article, and I will let you, layman for me. Okay. All right. This is the actual title of the article. It is a pre print article. So it should be what we're talking about here. When I say pre print is I'm giving you information before way before it's going to make the news way before. So this is why this is a hopeful podcast, very hopeful podcast. Potential inhibitor of COVID19 main protease empro, from several medicinal plant compounds by molecular docking study.Okay. Well, let's see, it sounds to me like what we're trying to do is use a naturally occurring substance, to eventually stop a virus.Through the protease inhibitor method,Well you said layman's terms last time my neighbor said protease was never. You're right. Yeah, yeah. You and I have different neighbors. My neighbors and I talk protease all the time. I'm surrounded. All my neighbors are infectious disease doctors. SoI know it. That's, that's what my takeaway is from that is, we are going to find how nature can allow mammals, humans to consume a natural compound and stop a virus from spreading.Yeah, so correct. So what they did is a researcher in China was able to successfully figure out or crystallized the COVID19 protease, that's the key step. And these guys took that person's science and said, okay, what is a potential target, to stop that protease? And they develop this very complex, cool study where they could show the binding energies. So when they say docking, the cell has to dock onto another cell. And then if it infiltrates, then if you give a protease inhibitor, it can't move. So they want to know how tight it binds to that protease enzyme. And what they figured out was they looked at three HIV protease inhibitors and 11 polyphenols.So and then just to reset into layman's terms, if you're trying to keep track of the the words, the way that I kind of have charted this together is a virus uses a protease like a key. The protease is the key for the virus to infiltrate and then deposit this mRNA so it can replicate what Dr. Brown is talking about doing is how can I stop their key from working? How can I make it so that this virus can can't use the key the protease to where the virus is using that protease to break down the protein so it can inject its RNA?Yeah. So the viruses, like we talked about before, are amazing parasites, they have to get into a cell, they have to replicate, they take over the cell, and then the virus starts going around. So these guys knew that there's three they looked at three HIV proteases. And then they realized that there's naturally occurring molecules in nature called polyphenols. And they demonstrated that the drugs and these 11 polyphenols appeared to have potent attachments to the M Pro with the M Pro is the protease on COVID19. Therefore preventing the virus from replicating their fin...their final conclusion was like all good bench researchers. Further research needed to do human trials.Sure.So they have a model with the virus and these polyphenols bond tightly. Super cool.Yeah, no without question. So essentially, they're saying if we can find a way to stop impro from unlocking the cell, then SARS COV2, or the coronavirus cannot infiltrate these cells.Yeah, so that was really cool. And then mic drop. Another study comes out of this one's out of Turkey and Pakistan. And I'm going to reach out to these researchers. They were kind enough to list their cell phones and emails on this study. I'm not sure that they meant to do that. Doesn't happen all the time!I'm gonna I'm gonna hit them up and I just gotta find somebody that can translate for me if necessary. We're going to do this. Their article title is identification of potent COVID19 main protease. Now you know what a main protease is empro. These guys took the research from the person that discovered it and did the exact same thing as these other guys did. So identification of potent COVID19 main protease inhibitors from natural polyphenols. And in silico, strategy unveils a hope against Corona. What? These guys saw that study and went, wait a minute polyphenols seem to be the way to go. This could be a new hope for Corona. This is what these guys are talking about. It's out of two very prestigious academic centers in Turkey and Pakistan. These guys are absolute beasts, I should say, guys, I'm just assuming there's probably women on the team also, that's rude of me to say these guys, but these scientists are beasts. So since its main protease was figured out, and remember I'll say it one more time, the protease allows the virus to grow and replicate. That is why we figured it out for AIDS. So they did a study where they looked at 26 polyphenols and one prescription protease inhibitor called nelfinavir. OkaySo these guys had the guts to say let's see what happens when we compare polyphenols to the current antiviral therapy that we use for AIDS. These results are absolutely shocking, Eric, this is I cannot make this stuff up. This is where my skin my hair just starts bristling. Basically 24 of the 26 polyphenols bound tighter to the COVID protease, then the prescription drug did. I'll say that one more time. It bound tighter than the drugs that we're thinking of using. Nice.And I'm really having a hard time trying to not be enthusiastic here and try to be scientific. I said it's gonna be very somber, scientific thing, but I'm just now um these are lab people. And these these guys, I could tell by the writing that their that excited I mean, when, when the title says, you know, exciting new treatment for Corona like these are bench researchers that if the numbers make sense. So this is not something to say that 100% this will work in humans, what we have is bench research stage one, stage two is to work to a human pilot trial, stage three is to do a randomized placebo control trial and so on. But this is so exciting to see that this is proven in a lab that these 24 out of 26 polyphenols and what this tells me is certain polyphenols did slightly better than others, as best they could tell. But the molecular mechanism is very similar it all is and then what they determined was it was a dose dependent, so you had to have enough of it to do it. So pretty wild.I don't want to jump too far ahead. But questions that are popping up in my mind are going to be number one is binding for the most part, preventing the virus from carrying out its activity. Because, you know, you don't want to just bind and be happy that you are bound, and the virus can go on. And the other question would be, what, what are the categories of polyphenols that happened to perform better than others? And do they all still you said 24 out of 26. So we know that two probably aren't ideal, but what were the categories?No, no. 24 out of 26 outperformed the prescription drug. The other two just were about at the level of the prescription drug.Thank you for the correction. So 26 bound.And I just want to clarify one thing I'm you and I are not virologists. The concept of protease I think, is more of a replication thing than a that's how come it works so well to stop the virus. I think it's more of a prevents the virus from replicating as far as binding. There's some different science with that. So just and I'm not a virologist, I'm a butt doctor. So um, so then of course that starts, you start going down some crazy pathways. I found another article that identified myricetin and scutellarein or something like that, which are polyphenols. Somebody else did a study as a novel chemical inhibitor of the SARS coronavirus. by blocking the helicase. The helicase was described as something needed to replicate. Yeah. So what I meant by I've just been exhausted is I read these articles and then of course, you stop. And it's like, I gotta go look that up. And then you end up going down a helicase pathway and I was just like, oh my gosh. The science doesn't matter. What I'm saying is there's people that are now looking in 2020, because they're doing the same thing I'm doing, they've seen the data from 2003. And now they're trying to see if that works on SARS COV2. And it appears it does.Well, is it a helicase? Isn't that an enzyme? Yeah, we hear about the double helix or whenever you see DNA after it's been scripted, and you see the winding, you know, mirrored image. Helicases, the enzyme that allows the assemblage of the mirrored DNA if I if I remember correctly, I could be wrong on that.So that is, that is med school year two USMLE. was done with that. As long as it passed. Um, here's another super I think I get pulled a gene like they pulled the gene out or something like that. Sorry, I don't wanna get sidetracked. I'm just kind of like...I don't know. I mean, dude, it's like clearly We're gonna have to get a virologist on to explain all the terms just say you guys are idiots. You're using the terms incorrectly. Let me explain it to you cool. I I welcome any virologist to to help us get through this because this isn't our thing. I'm trying to figure out how to take care of my patients. That's all I'm doing right now. Speaking of that. Another study titled small molecules targeting severe acute respiratory syndrome, human coronavirus. These guys looked at over 10,000 compounds, including over 500 protease inhibitors, 200 drugs, 8000 synthetic compounds and 1000 traditional Chinese herbs. Of all of them 50 were found to be anti SARS COV not COV2 anti SARS cubs. So this was a study done after the original SARS outbreak. Okay. Two made the best cut, one being a molecule called Aescin-AESCIN, the extract of horse chestnut.Horse chestnut. Yeah. Wow.And the other is a drug called reserpine which is a high blood pressure drug used in Europe. Huh 10,000 different compounds and Aescin the extract of horse chestnut is there. Okay, that's cool.Yeah, it's a polyphenol,that is a polyphenol/saponin. And we know a lot about that you can go on atrantil.com and learn about Aescin and if you want. Pretty wild. So that's my this is where this is going to go. We're going to be able to figure out how to optimize the appropriate polyphenols to protect your gut to protect your health. Those are astounding studies. It's I mean, I'm just fascinated. Alright, so everyone knows this. We developed atrantil. Atrantil are three polyphenols I have been into the science of polyphenols for over 10 years now. So now that I'm looking at this, this is not a sales pitch. This is a oh, my goodness, the molecule that I've been studying for 10 years, which is super complex and all this, I'm finding scientists around the world studying it and having positive results. That's what this is about. Nothing more.Now, here's here's the interesting part, though. So if it happened to only be a prescriptive drug or something that were synthetic, it would almost be completely imperative that that multiple rounds of trials and testing be carried out. Simply for the safety profiles so that they can be safely used somewhere. The exciting part to me is that what we're talking about is something that is already naturally occurring and is safe for us to begin to utilize as kind of like internal PPE. That's how I think about it as a frontline worker...Say what...say what PPE isOh sorry, personal protective equipment. So that was...Yeah, so one of the issues that if you're not in healthcare, the term PPE is being used because we're all running out of gowns, masks, gloves.Everyone is and it hasn't even hit our area nearly as intensely as it has like the northeast or the west coast, we're we're running outAnd you you as essentially, somebody who controls airways and you have to intubate people, you aren't so in the line of fire, so to speak, you're on you're that frontline person. You're one of those if you're an ICU nurse, if you're an anesthesiologist if you're a respiratory tech salute all of you, because you guys are right there getting into it. Now, some would say, hey, you spent the first half of the show talking about gastrointestinal issues. Yeah, I salute my gastrointestinal colleagues as well. Because it looks like we're in the fight now also.Definitely. It's just it's the takeaway, though, from those those studies, those reviews that you just had, though, Ken, don't you think that the exciting part on top of we think that we may be onto something is that people can begin to take action now with at least the data that is applicable, it's safe to use it worst and at the bare bones worst if someone happened to just simply start eating more polyphenols that they would take in from fruit yet, if it didn't work? Well. They're still getting great fruit and fiber etc. There's there's really no downside to applying a little bit of this, this reviewed science as we as we wait to find out that these are actual adversaries to the coronavirus. Correct. So polyphenols if somebody's like man they've been talking about polyphenols this whole time, what does that polyphenols are the molecules that make vegetables and fruit, colorful, it's on the skin. Those are the molecules found heavily in the Mediterranean diet. And those are the molecules that we now believe are anti aging anti inflammatory molecules. That's how come that we've been studying this so much. So I've been using it for gut health. So if at the very least, when you eat, make sure your plate is colorful, everything should be colorful. If you can imagine when you go to McDonald's and get your whatever it is. thing you lay it out. It's got a monochromatic tan across the...Very yellow...very yellow plate.Very yellow plate. You want to have green reds and purples and When you're doing that you're getting your polyphenols in knowing that the polyphenols could potentially help this. So that's super make sure that you at the very least do this. We know that they are very potent antioxidant, anti inflammatory antibacterial and antiviral. Yes. data to show all of that.Yeah, definitely. No, that's that's it's just a great takeaway to know that you can actually possibly be taking some serious action for your benefit and your family's benefit today.Yeah, totally. Um, so let's kind of get away from polyphenols and talk about what else you can do. But you're gonna hear a recurring theme here. It's, it's or fortunately, Mother Nature knows how to do this. And you got to take advantage of that. So let's talk about something so I've been getting tons of emails and patients calling in everything, what do I do for this and that, so let's talk about zinc. Why is everybody saying zinc? Why did they get buy get bought off the shelves? Why is it there? Well, zinc, if you're low, then your immune cells won't function well. And intracellular zinc can block the enzyme that allows the virus to replicate, which is an RNA polymerase enzyme. One more time, you take zinc in, very small percentage of it gets put into the cell, where the zinc then just goes, come on now, and they just starts working on the virus's rep replicating system. That's how it works as an immune product. And so zinc is an essential mineral that we need to take in, but you got to get it into the cell. So some scientists realize that we have to figure out how to get more zinc, intracellular. I got to quit touching my face, I just realized I'm messing up my hair and I...I've been doing it the whole time.Yeah, I'm realizing just I mean, I just get I get, I get excited about this. We know that zinc can inhibit, specifically Coronavirus, RNA polymerase activity in labs, but it has to be intracellular. The problem is that once it's in the cell, it can do that. But it has to get in there. And that's difficult to do. Scientists have realized and I keep saying scientists have realized I'm just referring to other smarter people that have done these studies is what I mean. So other people that are smarter than me have figured this out that it needs something called an ionophore to get in. So it's like a fast pass or it's a it's there's a security guard at the cell door, and zinc like a my humans eating all kinds of zinc. I'm here to help out and the security guards like you need to come in with somebody you need to have a VIP with you. Well, they're looking at different things that work as VIPs and as it turns out, flavonoids which are In the class of polyphenols, not only act as antioxidants, but appears in this particular study that they drove zinc into the cells, then they showed that with mice, they could actually show a rapid increase in intracellular zinc, when the zinc was taken with polyphenols, or if you're taking polyphenols. And also taking zinc doesn't have to be the same time. And they did this through very complex fluorescent staining. So that is super wild. You need zinc, but you need intracellular zinc. So really pretty, that one kind of blew me away also. So I just got done talking about two bench studies, where they work as protease inhibitors. And now I just showed you how polyphenols can work as zinc ionophores. That should be like enough, and we actually have more stuff to talk about, which is nuts. SoSo just in just a quick aside if if you have a diet that's comprised of good Healthy meats. What else? Beans probably seeds, nuts, various nuts. That's where you'll find naturally occurring zinc or...Cashews. Cashews are a big one.Definitely there's there but there are definitely some zinc supplements out there. So as a as Brown lays out different things that you probably could take at a molecular level, I'm going to try to keep up and say, places where you can find them so that you can incorporate them into your daily intake of foods.Yeah, so unfortunately, I'm just geeking out on this. So if you if you figure out how to say, Well, if somebody's sitting there going, Wow, where do I get it? Yes, absolutely. Thank you. Thank you for doing that. Um, something else. There was a study that came out of Korea, which showed that by certain probiotics in vitro, they could actually stop the hearing metabolism which this particular virus uses to get energy and one step further. That was in vitro then I found an article that showed that polyphenols work as an antioxidant by blocking xanthine oxidase which is part of the pureeing pathway. So the energy gets taken away from the virus as well. So that's super geeky. It's like, wow, it's like almost like every time somebody chooses to do a study on these polyphenols, they're finding a positive effect. We have gotten sicker since we have become industrialized, and we have refined foods. Having soil with rich and minerals and everything and eating the seasonal vegetables is probably a very effective way to protect yourself from a lot of illness. Not trying to say specifically COVID19 but doing that is probably a great way to protect yourself from a lot of things.Definitely hundred percent. I don't have a whole lot to add to that.Alright, so I'm tired of polyphenols, if I could ever say that I've only been talking about 'em for 10 years. So, alright. We did say on the first one that I want to give some recommendations about things that I'm telling my patients that I'm doing that my kids are doing that everyone that I think there's some science backing this. So other recommendations I'm telling I'm a big fan of fermented foods. I don't understand why but Germany continues to have this profound or I haven't, or a very a much lower death rate than the rest of the world. And I always laugh because I'm like, Is it the sauerkraut? I just keep coming back to them because the sauerkraut is it the beer. What is it, but so fermented foods, especially those that have Lactobacillus plantarum and bifidobacterium and lactobacillus generally will actually have been shown to have some antiviral activities. So now's the time to go out and get that kimchi now's the time to go out and eat that sauerkraut and that kind of thing. As you know, I'm not a huge fan of probiotics based on the science because not that it's there they're bad. But the science just isn't there and I don't want people spending a whole lot of money on things that don't work. I'm a big fan of polyphenol wrapped probiotics, kimchi, sauerkraut, things like that, because the insoluble cellulose, in my opinion probably works as a vehicle to get that bacteria to the colon. So, fermented foods. I'm kind of a fan of right now. We discussed zinc and vitamin C is an essential micronutrient that works as an antioxidant. What you will hear online right now and in forums is that studies in humans are extremely conflicting. So you have to go a little deeper than that. And that's the knee jerk that every doctor will say as well. The studies don't show that. I want to say this. Angie and I discovered an article with mice genetically grown, that do not have the capacity to make vitamin C. And then they took mice that are normal and they exposed...they exposed both groups to influenza, those without vitamin C died. Those who had it had a lot less inflammation and a lot less inflammatory cytokines. Right now in China there is an ongoing study where they're looking at giving IV vitamin C. So if you want to compare old studies that talk about the rhinovirus and does vitamin C help, what we know is looking at animal data, vitamin C is extremely important. And the reason why it's important is that we know it down regulates and inflammasome, inflammasome called NRLP. What that is, is we know that people are dying from what's called a cytokine storm, which is where your immune system overreacts to the virus. It starts with an inflammasome and then it becomes a domino effect. And just start turning on all these cytokines. So it also helps regenerate glutathione, which we're going to get into. And one of the only problems with vitamin C supplementation is if you take too much it can create some gi upset. When I was on Dr. Raun's summit, Dr. Lundqvist, who went on before me who's an expert in this did discuss something really cool, which I was unaware of when you are sick, you increase what's called your glute one receptors. So you will absorb more vitamin C that you take in, so your body knows when you're sick. So if you're not sick, and you're taking tons of it, you're probably gonna have some gi upset. If you're sick and you take a little extra, you'll probably be fine, which I thought was really cool. So I love learning from other really smart doctors. Next product everybody goes on vitamin D. Yes, we know that most people in the United States are vitamin d deficient in a systematic review, vitamin D appeared to protect individuals from acute respiratory infections. Vitamin D is expressed on both B and T cells, which are our immune cells. And what it does is it can modulate your immune response. I'll say that again, it can control your immune response. So it almost works more like a hormone in that it tells your body to not overreact, which is something super important. And low levels are associated with increased autoimmune disorders and increased infection rates. So looking at a different study, it looks like that taking high dose vitamin D on a weekly basis, which is what many doctors recommend, is not as effective in this particular case as taking a daily vitamin D supplement. So I would recommend somewhere around 1000 milligrams a day. Most supplements come in the 2500 to 5000 range but I'm on it and my family's on it as well. So super important to do thatThing here so vitamin D foods are lot of your oily fishes, dairy milk cheeses and I think some of the greens like collard greens and mustard greens I think have vitamin D and of course don't forget you need to convert it. Get sunlight, get sunlight every day.Yes, go out for walks. walk your dog Get out right now is a great time to get out. And yeah, thank you for saying this. I should have started with everything. I'm not saying get out. I should have started from the very beginning. Don't go out and buy a bunch of supplements. Try to eat the diet that has these ingredients in them first. Supplements supplement a healthy lifestyle, but is no substitute a healthy lifestyle. So that being said, Yeah, so thank you for bringing up those foods. And I will throw this at you now. A diet in healthy phytosterols. Phytosterols are vegetable oils that appear that they may block the binding site of these different Coronaviruses. In other words, the ACE-2 receptor that they keep talking about in the news uses cholesterol to bind to what is called a lipid raft and then that lipid raft of the virus binds to it and then it kind of slides down. I always think of it like the way that they describe those inflatable rafts when a plane lands on the water they come out and people come out that's how I think of it.Don't you want to get into a situation where nobody gets hurt but you get to pull it I always wanted to inflate that stinking thing.So a diet high in phytosterols. So things like you know what I'm gonna beat you to this one because I had that I actually had to look this up phytosterols isn't something phytosterols are very high nuts, legumes, grains and fruits and vegetables. It's a common theme here. We keep saying the same thing over and over. I mean, don't eat at McDonald's, eat your fruits and veggies, and healthy fish and things like that. And two more. And then this is this rounds out my list of science backed supplements that I can, I can at least lean on some data. Because there's a lot of things out there that people talk about. That is not my specialty is not my that I have not had a chance to get into. But n-acetylcysteine is something that I'm a big fan of, n-acetylcysteine (NAC) has some mucolytic properties. And in a 2017 meta analysis, meaning in 2017, they took all these studies, they found that treating patients with NAC NAC and n-acetylcysteine led to shorter duration of ICU stays in acute respiratory distress syndrome, which you geeked out on on the first episode explaining all about ARGS. So go back and watch the first episode because this is Eric's specialty, keeping people alive with that kind of problem. So salute to you for doing that kind of stuff. And Chinese protocols right now Chinese hospitals are using n-acetylcysteine as standard treatment when somebody comes in with coronavirus. It also does something really cool it increases glutathione levels. Glutathione is one of the most important cellular antioxidants. So what that does is it is a potent cellular antioxidant, and we need this for cellular health, cellular health kind of funny the guy that went on after me was Dr. Dan Pompa, who I who I love and his his whole his whole mission is cellular health, which is cool. A study looked at people with community acquired pneumonia, and they randomized them to either conventional treatment which would be antibiotics, and...conventional treatment antibiotics plus NAC. And what it showed was the NAC group healed quicker and had lower inflammatory markers. I'm currently taking like 600 milligrams BID, the dosages were all over the map in all these studies, but wow, okay. There's studies out here that show this and they essentially are you and I have talked about how NAC helps with alcohol metabolism, but this is a whole separate method. This is getting the glutathione and then ultimately, I'm recommending melatonin as well. Melatonin is a potent antioxidant. But one of the reasons is to make sure that you have everything functioning well. You got to sleep. During these very stressful times. You've got to get...try get eight hours of sleep. Please, please, please, please, please. And this is nuts. Kids don't seem to be affected by this virus and one of the speculative things is that kids have much higher melatonin than adults as we age we decrease our melatonin so over the age of 70 you have much less melatonin. I read an article describing how the higher melatonin that you have you in your NLRP3 inflammasome. inflammasome yeah.Is down regulated by melatoninNice.You have your highest melatonin traditionally between ages one and five. And as we age it decreases and if you do not have a high melatonin you are susceptible to a cytokine storm cytokine storm as we talked about is your body overreacting. So one last time did you write those all down Eric? Can you...I did.Tell everybody what what what I feel science backed things may help during this pandemic,In addition to a healthy diet of polyphenols or supplementation with polyphenols and of course we know where you can get that with Atrantil. There is strong science to suggest that you should couple a polyphenol diet with zinc, vitamin C, NAC or n-acetylcysteine, vitamin D, phytosterols, and melatonin. You can get zinc and NAC from meat, eggs, etc. Your vitamin C obviously comes from great citrus fruits and vegetables. Let's see here phytosterols there's tons of plants and seeds that have that in it and of course, if you don't produce enough melatonin that is a very common supplement. However, I will say though, that you want to be selective on probably where you where you buy melatonin that seems to be one of those. Oh yeah, yeah we that's a whole separate show. I actually pay to belong to examine.com and consumer labs.com. I'm a user because I go there and I have them do the analysis. That's a third party analysis. So any of these supplements make sure that they're third party analyzed. So those are the ones that I can sink my teeth into really deep and go, this clearly looks like this. Now, there's other things that a lot of other people will be like, oh, well, what about this? What about this? What about that? I'd like for instance, broccoli, broccoli, or sulforaphane? Sulforaphane comes in broccoli sprouts. I found some articles that show that coronavirus may decrease your NRF two pathway which is the pathway that leads to inflammation and that so I'm also taking that we know that that actually has some antibacterial effects. Shivan and I got kind of deep into it yesterday in the CBOE summit, where we talked about how I'm using that in my CBOE people as well. I'm having pretty good results. So that would be one that I can't really say, I've looked at the science, but I'm seeing anecdotal evidence and it's probably good for you anyways. So if it has some ability to help with this infection, that would be awesome. And we know that like, CBD attenuates the immune system, so it at least gets you back to balanced immune and neurologic systems. So I'm obviously a big fan of that. And that's you can go to our website and take a look there. I'm not saying not recommending it, that this is any type of cure treatment or benefit to this particular pandemic. I'm recommending to make sure that you're doing everything you can to try and improve your immune system.Definitely, if you're if you're a frontline health care worker, just be certain that you're doing all you can to take in a good diet. Be certain to get your exercise and know that you're probably hustling all over the hospital floor or OR just taking care of patients even if they don't happen to be COVID patients. You want to be certain that you're keeping yourself nice and healthy in that environment, get sleep, no matter what just prioritize sleep, your immune system just will never be as strong as it possibly can if your body is not getting rest, so sunlight, sleep in addition to a good diet, it will make for a much better outcome in the long run for certain.Definitely, we and we won't stop these installments for the COVID talks until we we more or less feel comfortable that we're heading that direction. I will say that we've been put in contact with an infectious disease doctor in the Department of Defense that actually he probably can't join us live or recorded on the next installment of of the COVID file. However, he is going to vet some questions that Dr. Brown has sent his way. Basically just just read his responses back. Yeah, absolutely. And we want to, once again, thank everyone who's worked in the hospital systems working, shift work, or EMS people. You guys are the true heroes because you are doing shift work you affect your sleep cycles, you're getting a lot of stress. I know I've talked to some emergency room physicians who are seeing other issues with this shut-in like, unfortunately some more domestic abuse going on and things like that because people are forced to being you know, the finances are tight, and the the quarters are tight and everybody is you know, struggling but hang in there. We're gonna get through this and what I just got done telling you even if you even if you're sitting there like it's been like what I like turning it because you guys like to joke around what do you do? I was just nerdy. Just bottom line is, it looks like we're heading in the right direction for figuring out how to how to stop this.That's perfect.Got a little bit different perspective as an ID doc, as well as tending to the pediatric side in combination with ID. That said, though, it probably won't be a full week until we come back with the next installment simply because we're finding some more time to dedicate collecting research and kind of really getting it organized. We certainly appreciate everyone sharing the last installment. Hopefully, we'll do the same here. And when the show notes for this one on the YouTube YouTube presentation, we'll be sure and list all of the supplement lists that that Ken laid out for you. And I don't know, it's a pretty powerful episode. I hope that people can begin to arm themselves and I think that the next time we're going to have some some good feedback and start rounding the corner to better days.Yeah, yeah, definitely. Well, appreciate everyone tuning in. appreciate everyone staying home. It is real. We still have to practice at least right now. What's the you know we're in March. We're still practicing social distancing.I almost forgot and I'll put this in show notes also, if you're looking to just make a difference in your community, Ron Lynch is a really close friend of Dr. Brown and I his name as name is Ron Lynch. He just started intellihelp about a week ago or a week and a half ago and intellihelp and intellihelp.org IntelahelpHelp. HELP. Intellihelp can be founded intellihelp.org. And intellihelp is intellihelp on Facebook. What it does, it's a very free service if you are available to give and help in service in any way. They've done really, really well over the last almost 10 or 15 days of if a woman needs diapers to take care of her kiddos and she doesn't want to leave the house. She just basically posts it someone who happens to be coming back from grocery store drops it off someone that kiddo needs to have an availability to have a free lunch dropped off because they're not getting lunches from school. Yeah, intellihelp is there to serve those people and to give you the ability to give back to them and trust me, if you feel a little bit down in the dumps, you'll feel a lot better once you're able to help somebody else and you feel like that you're notThat's awesome. That's awesome. So how do we prevent like a you know, our partner Mike Logsdon from gettin' on Intellihelp said I need a Guiness delivered to my house right now.There's no way to prevent that from happening because because Mike may need that Mike may need that Guiness. That is true. I have a feeling that as close as you live once you get on intellihelp Ken you'll be...Loyda goes where are you goin'? Mike needs his Guiness again.There's nothing I can do. I'm going to drop off some diapers and some can some some black aluminum cans at Mike's house.Yes. I love that. Awesome. Well, Ron Lynch, kudos to you. That is badass. Awesome. Thank you for being part of the solution.Definitely, definitely. All right. Well, I think that's the the end of second summit will be like I said it won't be a week until we get the third in. And we'll get a little bit more regular, a little bit more frequent as more news evolves. We're just kind of setting the stage here. But yeah,And if everyone can just comment, and let me know if you want it this sciency not so sciency. I mean, we're, we're, we're all learning as we go during this, because the because everything's coming out by the hour. Yeah. And we have the ability to go as deep as you want. We have the ability to find stuff that is not in print yet. And that's what I like when we're talking about stuff. And then three weeks later, the news we were talking about the anazmio well before it even made the news.Yeah. Well wondering if it was true, right. Remember that you said have read this. I have no idea if this is even accurate. I mean, between that and people shoving hair dryers up their nose, we didn't know which direction to go.True. Heat up the nose. That's right.Don't do that. It's terrific idea. All right. Well, ladies and gentlemen, thank y'all so much for tuning in and sharing a next installment here rather soon and they may not all be nearly this long, we may have some shorter...How long was this?Right in an hour? What? Yeah.It felt like 10 minutes.It's just a lot of info. Well, thank you Ken and, Paul, thanks for of course for putting everything together. We will see y'all next time on next COVID installment. I'm Eric Gregor. That's Dr. Ken Brown here with a gut check project. We will see y'all next time.Stay safe, everybody.

CBD causes liver failure?

director science baseball idea publishing machines elsevier scholarly communications mendeley

Play Episode Listen Later Dec 19, 2019 100:49

All right. Welcome to the gut check project. I'm here with your host, Dr. Kenneth Brown. I'm Eric Rieger. This is gut check project, Episode Number 26. We're going to wind up 2019 with some awesome info. What's up, Ken?What's going on Eric? How are you doing, man? Episode 26. Unbelievable. I apologize if I'm a little too sexy today because I'm just coming off of a small cold. I think the hottest people are those that are sick.Well, I'm not sick. I'm post sick. Remember, the viral prodrome. The reason why we always like pass so many viruses is that you tend to pass the virus before you even know that you're sick by the time you're actually sick. You're probably okayYeah. At that point you can go back and say I heard you might be sick. I was too back then.Yeah, exactly. Good to see you?Well, today's episode is going to be pretty awesome. We're going to tackle number one, we've received tons of email in your clinic because you also sell the KBMD CBD at your clinic, you get these questions. These have been coming in Fast and Furious over the last little over 14 days. And it's questions about the safety of CBD oil and its application. So we're going to tackle that I do need to tell everyone. Thank you. We're on episode 26 because the first 25 shows were so well supported by all of you who've been keeping up with a gut check project. We grow every single day. Paul, the guy who's helping us put together the production now and helping us spread the word. We just hung up the phone with him. We've gotten more and more downloads each week. So thank thank you every single one of you for liking, sharing, emailing, telling your friends about it. We sincerely appreciate it.We learned so much about it like today we have a new a different guests we do Instead of gutsy our little mascot or green frog, but since we do film on a green screen, he gets blocked out did not know that didn't even realize that. So now we're going to go with a dung beetle, right here? Yeah, yeah, we did. So that's Dilbert, the dung beetle,Dilbert, the dung beetle. So one of my favorite things is whenever we're bringing any patients back and somebody sees you, and they're like, hey, you're Eric, I watch your show that just warms my heart. So if you happen to be a patient and show up and you watch the show, if you say that it just makes us both feel really, really well...needed wanted, appreciated.Yeah. At least outside of me putting you to sleep. Take five or six good deep breaths. Exactly. Today's episode is sponsored by Atrantil. Your bloating relief, it's what we do. So go to Atrantil.com or lovemytummy.com/KBMD. Today it's also sponsored by KBMD CBD oil. You can find your own KBMD CBD oil at kbmdhealth.com which of course, the initials KB, Kenneth Brown, it's endorsed by the guy who's sitting across the table from me. So Ken, why is...What does MD stand for? Well, I'm not really sure.I thought it was your buddy Mike Doyle, but I don't know.Yeah, it's probably. So tell us a little bit about KBMD CBD. Alright, so KBMD CBD oil. I got involved with the science of CBD because I saw the beneficial effect with my patients when we developed Atrantil I then learned that the science of Atrantil the polyphenols in it actually augment CBD. So I'm seeing this combination do incredible things for people. So this particular CBD is one that we have researched, I've seen it work clinically. And we know that it comes with a certificate of analysis. It is organically grown, it is naturally extracted with co2, so it meets all the criteria that you want in your CBD because this is important. The rest of this podcast is going to be all about the dangers of CBD.Definitely and It's really interesting since we do have so many people who have begun to purchase CBD find benefit. It's really kind of weird what's occurred over the last two weeks. And what I would say is a little bit of misinformation. But it's more or less probably just misunderstood information and or or misapplied information. But regardless, the benefits of CBD used correctly, have been undeniable with the people who've come back through the clinic with people that we've scoped, and how well that they are doing. And so, hopefully today, we're going to provide some context on why more or less the dangers that you may or may not have read about in the news recently are really a little concerned. But we'll, we'll see. We'll see how far along we get in at the last. The last thing. Our last sponsor is the KBMD health box. You can find KBMD health box by going to kbmdbox.com. Now last week we did a full unboxing which is something I think we're going to try to do at least once a month. But essentially, if you want almost $300 of physician vetted supplements that can help you benefit your life and get them for only $147 which you would spend, not you would spend more than $147 worth of time driving somewhere to pick them out for yourself and having someone handpick them for you. Go to KBMDbox.com. What was one of the things that we had a patient come through just earlier this week, who showed us his lab results that he took to his primary care physician? So we're starting to make a difference in the landscape of health here in the DFW Metroplex and different places. I've been getting emails and calls from people around the country that will actually hear the podcast and then they'll want to sign up for the box. And what we're seeing is that these vetted supplements actually are making a difference with both subjective how they feel and objective the labs. So the reason why I chose these things is they all have third party analysis. And they all have some scientific background that actually explains how they're going to help you. So much so that I'm thinking of ordering my household, another box. So although it is the KBMD Health box, I actually I love the fact that I can get these things that I'm going to purchase anyways, they come into my house, so my whole family's on it. Now we're running out of stuff. So I'm gonna end up having to double up on everything. So it's one of those things that I feel really good that we can look at different aspects. And when somebody says, Oh, I tried X, Y, and Z, I didn't notice anything. I'm like, oh, did you try one that had a third party analysis? No. And then they do and they're like, Oh my gosh, big difference. Same thing with CBD. I mean, a lot of CBD out there doesn't really have what's on the label. And we're going to get into that because we're going to talk about what the FDA thinks about it. We're going to talk about the different media and what they're doing, and hopefully get into all that but that's the whole point of that box is I want to deliver these vetted things to your house monthly so that you can continue to improve your health. Hundred percent. So without further adieu, be sure to like and share the gut check project. We certainly appreciate all of the support to date. We're going to hop right into it. So what we've received here recently is a lot of speculation and concern from people who have said, Hey, I'm interested in CBD. I know that you and Dr. Brown have heavily studied, been entrenched with CBD and its application over the last few years. I just learned that the FDA is associated or made public a study that says that it may be hepatic toxic or bad for my liver. It's, unfortunately, it's a weird jump off point. So I'm going to kick it to you. Because immediately I had lots of different thoughts and instead of getting emotional, what did we do? We went and tried to find the sources of where this information came from. We want to backtrack on how they got to that conclusion. And I think that we can put a lot of questions at ease and even help people learn how to be a little bit more critical with the data that they receive when they receive it. Because let's face it, lots of stuff that we see on the internet, or that we hear on the news or reading the paper, it's basically clickbait. It's basically things to keep you engaged, whether or not the actual substance is worth the headlines that are written so...So what you're referring to is recently the FDA put out a statement, a consensus statement in the news and it's making all kinds of traction in the news that they're saying that CBD is not as safe as people think not only that it can be harmful. Now this has bled onto TV and my patients have been asking me about this FDA statement. Then there's been other news articles like the one that Forbes published, read said that CBD causes liver failure. Failure. That was the title liver failure caused by CBD. I want to get into all that I wanted to take a really deep dive into the science of all of this as a gastroenterologist, I'm board certified gastroenterologist, which means not only am I a simple country, butt doctor from Texas, but we actually have to learn liver disease, hepatology, I'm not a hepatologist like some of my other friends where I send like really complex things, but we at least have to understand the liver, how it works and what it does. So a lot of these articles discuss this but they don't clarify so many little things. Because and they shouldn't it's a it's a journalist writing an article they want they want it to be shared. And anytime you mentioned CBD, anytime that that is thrown out there, you're going to get some clicks, you're going to get a whole lot more clicks. If you say you're going to die from taking CBD. It reminds me of the I remember Jerry Seinfeld was on Saturday Night Live one time and they were making fun of the nightly news where they always do the promo at like three o'clock. Like five household items that are guaranteed to kill you, tonight at six.You're like what? If it was so important, they probably wouldn't make you wait.No, I'm gonna die before you put this on the air. So what I'd like to do is talk about the briefly the science of the endocannabinoid system and CBD, then do a little bit deeper dive into the liver. So everyone's going to get a primer on the liver 101 here, because these studies don't make sense unless you know, some of this knowledge. It's just sensationalism. For some of it, some of it is a little bit unfair. I think some of it is for what the FDA got, and it's there. But I just want this podcast today to be something that can be useful for industry people that can be useful for patients or people that are thinking about taking CBD and it can be useful for a subset a small subset of people that may be should not consider taking it. Yeah. So all of this is kind of, you know, for the future of this podcast, It's almost going to be a bit of a rebuttal. Not necessarily a defense of hemp derived CBD. But let's just buckle up and kick some science. This might be a little bit I don't know how long we're going to go where we're going to go with this. We're just going to feel it out and see what happens. But I at least want to be able to explain why I still believe that a lot of people should be taking CBD even though Forbes is like you're gonna die from this.Yeah. It's not arsenic people. No it isn't and I think another cool application here is there are people out there who have been on the fence on whether or not I should try CBD or is this something that's good for a family member for me? And unfortunately, there you hit this intersection, where a news headline is written that CBD causes liver failure. Well, if they've been on the fence, that's a pretty big No, no, right? So now you've taken away maybe an avenue that they were considering to help them out. What I hope that we can do with this particular episode is basically let's temper and let's see things in context. I think context is a word that as you get into sensationalism is something that is kind of the rescue item. If I could put something into context, then at least I'm giving someone a fair chance to understand the information that's before them. I don't feel like sensationalized headlines do things like that. Then again, I also don't feel like someone who shakes, hand picked or cherry pick studies is doing that either. So what I think today that we can do is fairly evaluate and talk about the process of how the liver works, and why some of these studies are or are not applicable to the nature they were presented.Absolutely. So the first one we got to discuss is what what what the heck did the FDA say? Sure. So the FDA came out and they mentioned that they've got several issues with the safety of CBD. The two main ones that they're really concerned about are potential for liver injury, and interactions with other drugs. What they actually said is that they're concerned that people may mistakenly believe that trying CBD can't hurt the agency wants to be clear that they have seen only limited data about CBD safety. And these data point to two real risks that need to be considered as part of the drug review and approval process for the prescription drug containing CBD. Interesting. Now, what I say this is because the FDA is referring to the data that was presented to them by GW Pharmaceuticals, who has a epid... eipdi..x you know?E-p-i-d-i-o-l-e-xYes, which is the first FDA approved prescription CBD isolate,Right,for seizure disorders.It's important to point out that is not full spectrum. Correct. That is not full spectrum. And there's some that's important because here later in the podcast, and think we're going to draw some comparisons and just if you're listening, just remember, epidiolex is a CBD Only isolate it is not a full spectrum product.So let's talk about what the FBA what the FDA actually does. So the FDA has a really daunting task. The Food and Drug Administration is responsible for protecting the public health by ensuring the safety, efficacy and security of products. So it is super daunting because there's a lot of products hitting the market, and the FDA has tried keep up with this to try and protect people. And let's be honest, let's look at the elephant in the room. The elephant in the room is that there are a lot of bad CBD products out there. Yep. In fact, in a jam article 2017 showed that 70% of the CBD products that they looked at did not have what was on the label and what was there could be higher levels of CBD could be lower levels of CBD. So it's a gamesmanship that's going on right now. So it is totally true that you need to make sure that you've done your homework on what type of CBD that you're actually taking. There currently is little to no regulation in the CBD industry. There is the President and CEO of Natural Products Association NPA. His name is Daniel Fabricant. He's a PhD. I love this quote. He's quoted as saying it is well past time to bring science into the equation, as federal rules require safety and Consumer Protection must come first. I agree. And we all agree with that. Sure. And I think that all companies that have reputable CBD companies, they all want that. Problem is when you have these different stories leaking out, which gain much more traction, it just starts creating a little bit of confusion misconception, and then people don't really know where to turn. So the feeling is, is that possibly statements by the FDA saying that it creates this narrative that questions the safety of CBD overall, strictly to address a few number of companies which are producing quite frankly, some crap products.What was the number that we learned the last time that we were in Utah at meeting I believe it was one out of every 23 to 24, I could be off it was definitely in the 20s. But every to every 23 or 24,25, CBD labels available for retail purchase. One is seen as a reputable well marketed or correctly labeled product, which means that even if it happens to be off a little bit, you've got 23 or 24 other labels which are just not truthful or probably not correct, don't have a certificate of analysis or are blatantly, just not even what's in the bottle.100%. There's a lot of people out there trying to take advantage of this wave that's coming. So I do not. I believe that the FDA is doing their job by looking at the data that was actually presented to them Agree. So let's take some time and break all this down for the consumers, health care providers, industry personnel. Starting with the question, does CBD cause liver damage? Unfortunately, or fortunately, because I like science we really need to talk about what the endocannabinoid system is. Because if somebody's listening to this, they're like, Well, I was thinking about taking this but I'm worried becasue it can cause liver failure. I don't know why I'm taking it. Why in the world should I be taking it? So let's do a quick one minute discussion of the endocannabinoid system. Let's do it!All right, the endocannabinoid system. The endocannabinoid system is a system which was discovered in the 90s that we now realize it's probably everywhere in the body. There's primarily two different types of receptors, but essentially, the way that I try to explain it to my patients, it's concentrated more so in the neural areas, nerves, brain and the immune areas. Although we now know it's in every single organ, that's where all the original research was. We now realize that its job, the endocannabinoid system is to produce these products called endocannabinoids. Which work as traffic cops. They just kind of get your body to get back to an area of balance. If you've got too much activity, they go Whoa, slow down a little bit. If it's not enough, they go, come on. Let's go ahead and get some more going here. So you have this fantastic system in your body that really just tries to keep balanced. Think of it that way. And you're going to hear a little bit later why I think most of America is out of balance. I think most of America needs some replenishment of their own endocannabinoid system. So that's the important thing is is that there's a dire need to try and get us all back to a certain balance, because the reality is we're getting sicker as a nation. And one of the causes could be that we took hemp derived foods out of our diet and out of our livestock diet. And there's a theory on that, that possibly that's one of the reasons why we're having more autoimmune diseases, why we're having more of the other problems that we're seeing, Well at least contributing factor.Certainly at least a contributing factor. So keep this in mind. So the the primer on the endocannabinoid system is if you're, if you have ears and you're hearing this, you also have an endocannabinoid system, and you have a higher than likely chance that you are out of balance with that. And if you are out of balance with that, then you probably could benefit from some of this. Sure. So right now you're going well, I'm out of balance, I'm going to probably benefit but I'm going to go into liver failure if I do this. So let's talk about what liver failure means. You have a genius living within you. You probably have multiple geniuses living within you.Thank you. That feels great. Sometimes the voices in your head don't say to do bad things.The evil genius. Yeah.Well, one of the geniuses living within you as this beautiful origin called your liver. So you have this and it's amazing. So to understand where they're going with this, let's talk about what the liver actually does. So we all have livers. And they work differently in every single person, and they can continue to adapt, evolve and change. One of the only organs that you can transplant a partial portion of it and it will grow into a full liver. So the nephrologist think that the kidneys, the smartest organ, the neurologists will think that the brain is the smartest organ The cardiologist says if you don't have blood, you can't think so It must be the heart. Yeah, yeah, exactly. I'm gonna say, well, for health span, smartest organ in the body is the endocannabinoid system. So eventually, we're going to have Endocannabinoidologists. Because what ends up turning out is that the endocannabinoid system is in all these different organs.Correct.They're not completely separated. So let's talk about the liver. The liver is responsible if you ever wonder what the liver does. So do you have any idea what the liver does? I've got a little bit of an idea... Little bit of an idea. So the liver is responsible for selective uptake, concentration, metabolism, and excretion of the majority of drugs and toxins, also known as xenobiotics. So let me just say that again. Basically, the liver takes the crap that you bring into the world. And it says, I'm going to convert it to something useful, or I'm gonna get rid of it for you. Yeah, it can detoxify it, or it can say, Oh, you need to be this and then you're useful. That's why I say it's a genius in your body. And it the liver figures this out, it figures out what you need, and it determines if it's a drug, or if it's a toxin, and it can turn into a better form. Now, one of the problems I have with these different articles that I've been reading, is that they discuss that then enzymatic process called the P 450 system, and they just write it like that they're like, CBD has been shown to affect the P 450 system. What doesn't affect the P450? So that's the issue. So let me break that down, I bring up the P 450 because in the lay literature without even describing what it is, it is a complex. It's called a phase one metabolism of the liver. Under p 450. It's an umbrella term that has over 60 different genes, that code for hundreds of enzymes to break down anything that comes your way. So the P 450 enzyme is like saying, Oh, I don't even know an analogy, but it's top of the funnel down. It's like you just so generic, that you can't just say that. So but they write it in the lay literature almost as a sounds sciency so I'm sure that it's, I'm sure that it's right. That's kind of my feeling on I'm like, why would and all these people it's almost like these news articles parrot each other. And nobody's stopping going, wait a minute, because as it turns out, the P450 system, not the P450 enzyme, the system breaks down almost everything that we put in our bodies. Yeah, no joke. So a lot of going back to the pharmaceutical days, I remember that was one of the biggest challenges with with any of the drugs that we detailed a physician on was, how is it affecting the P 450. And that would be something that they would be all salespeople be coached on that before they would go on calling a physician. But the truth is, it doesn't have to be a compound. It doesn't have to be a medical pharmaceutical compound for that to be somewhat important. Something as simple as grapefruit juice. Also, detectibily inhibits the metabolic ability of the P 450. So there's all there's a handful of different drugs that people who are elderly, maybe caution, don't drink grapefruit juice, because it will inhibit your ability for your body to clear this particular drug. And I say that to say this. It's not nothing is inherently just special because it does or does not directly affect the P450, almost everything you take into your body is either cleared quickly or slowly by that same system.Yeah, so they kind of imply like CBD is the only thing that gets...Not even close....that gets processed in the in the P450 system. In fact, we know that there are multiple medications that can be altered by certain foods. Grapefruit is the most common one, and that really affects like immunosuppressants tremendously and that's where it really came up. When they realized, oh my gosh, you have these different drugs, let's say blood thinners and immunosuppressants, which have a very narrow therapeutic window, you have to have these things like right dialed in. Yeah. And then people talk about grapefruit but you know, other things that have actually been shown to do this cranberry juice, black tea, pepper, even chocolate Yep. has been shown to affect drug absorption and they have been shown to affect certain pharmaceuticals. We don't even know the tip of the iceberg on this because you have to do the study on it. You have to do the pharmaco kinetics, the PK is what it's called to actually determine that which is so funny because they say oh CBD is metabolized by the P450 system. That means nothing. And so if you take CBD and or chocolate and or drink tea, be careful. I mean...I think a good analogy a seriously a good analogy is it the P450 being metabolized by the P450. It may be good for base knowledge, but the truth is, is does it overwhelm that, as you put it system, if it is overwhelming that system, chocolate, for instance, for most intents and purposes would be like a single car driving down a six lane highway by itself. It's not really if the highway was a P450 and the car was the chocolate. It doesn't take anything to funnel that that car through.Correct.The problem is is whenever you happen to overwhelm that system. And that is important to know. But I would say in terms of context, kind of the way that we started this discussion in context. It's not my belief through what I've read and seen that CBD inherently overwhelms or becomes more than a single car down that six lane highway.So not only is it just one single car going down the highway, remember that not only foods but drugs, nobody's talking about drug drug interaction.Right.So there's a reason. So I see a lot of patients that one drug may be very effective one thing may be very effective, but there's so many variables like for instance, drugs, the sex of the person plays a role, you may have different levels, the age of the person and any diseases can all affect this whole system called the P 450 which produces enzymes. So not only that, but then genetics play a huge factor, alcohol intake.Alcohol intake, all of that. I mean, genetically, this may be why some drugs work on certain people and why they don't work and others fact there's a whole field of science right now where people are trying to determine the genetics ato go, Oh, you're going to need a higher level of whatever Plavix which is one that they've actually looked at. Or you can, you're going to take less. So we this is a whole field of this beautiful science where we can go Okay, genetically, you're going to be predisposed to need more medications. So when these enzymes get used up, basically if you've got this one chocolate, which is a car, one on six lane highway, and then you add fluconazole, which is an antifungal, that's an but that's not a car, that's a semi now and then you add alcohol, which is a minivan could be ccould be a couple minivansand then you do whatever something else, but you can see that the liver has to try and process this right. So what happens is it becomes this once it becomes a traffic jam. Then people start getting angry, they start honking their horn that is a rise in your what we call lfts liver function panels liver function test Yeah, so AST and ATL are the two ones that we always talk about, that's exactly what the FDA was referencing. So I want everybody hear this. When you overwhelm the liver with multiple cars using your analogy, then honking starts and the honking the warning sign is this rise in AST and ALT. So, for instance, your body can adapt to it. We've seen this all the time. If you drink alcohol on a regular basis. you build more lanes, you build more lanes, you get really good at metabolizing alcohol. Build tollways. I'll use myself as an example.Not with alcohol.With coffee, Okay.I always have to laugh. Whenever I go to the my own doctor. They say how much coffee do you take? I just write obscene amount because I've down regulated by receptors or I've had the ability to ramp up my my livers ability to convert that coffee into an inert thing and there it is. So you see it as an anesthesiologist or as a crna. I mean, describe what your experiences whenever you try and put somebody to sleep using propofols, different medications.Yeah, well, I mean, definitely, if someone says that they happen to be a large consumer of or a consumer of large amounts of alcohol, it generally takes anywhere between 20 and 30% more of an agent to put them to, to sleep safely, say, But back to your point of body habitus, for whatever reason, even just something as simple as someone being a redhead fair skinned, those people generally take more agent to make them go to sleep. Yeah, let's go ahead and clarify this. This is a well known thing in anesthesia. You're not being prejudiced? No, not at all. No, they literally just for whatever reason, the metabolism rate of someone who's fair skinned with red hair is typically higher than the average calculation and you can go through any types of weight based medications that we use to bring sedation to someone and generally fair skin redhead folks just take more. Is that interesting?Yeah, it is. So that is more than just anecdotal like they've actually done some studies on this and they've actually shown probably because whatever lineage, they come from Scotland, Ireland, they have a higher P450 to metabolize that particular or a higher subset of the P450 systems. So just keep that in mind. So when you take certain foods or drugs, everything's competing for your liver, to do to just say, hey, fix me, you know, figure out what's going on. Fortunately, it is a badass organ and the liver is tough and it can handle a lot, the largest solid organ that we have in the body. So usually it can handle everything. Now the most common example like we've talked about, if you take grapefruit juice with certain immunosuppressants and things then that particular combo because those drugs need exact or how they were manufactured need exact metabolism numbers. Not only that, did you know that like nutrition plays a big role. So, high protein diet will actually affect your P 450 and malnutrition will affect it. of course it will. So those are all of our paleo friends over at paleo FX and such those guys have revved up p 450s. Eating a lot of protein working out a whole lot, they're able to do this. Unfortunately, malnourished people probably can't tolerate as muchNo and they aren't they aren't they honestly they don't have the supply to rebuild the enzymes that are that are used within the P 450 I mean it's just malnutrition is going to deplete all different types of systems, not just the liver.So in the intro, I kind of mentioned that we're getting sicker. And so let's use nutrition as an example. federal policies tightened by the controlled substance act of 1970 essentially banned the production of industrial hemp during the war on drugs effectively we made hemp CBD illegal and put it under the umbrella of cannabis cultivation. Now what were we were talking with Will Clyden of O-hi energetics right, who actually discussed this and he said some cool stuff on this. He back before this when they were they were using hemp and hemp has been used for ever like since we landed in America, hemp has been using hemp has been used in China for thousands of years and all this other stuff that we were feeding because it's a fantastic crop. It's it detoxifies the soil. And it actually works. It grows quick. It's a great crop industrial. What were we thinking making it a banned substance, I don't know, separate discussion. But they've got data to show that when they were feeding chickens, so for everybody out there I had a patient today who said I said Oh, she was suffering from some things and I think CBD would help with and I mentioned Hey, have you ever considered CBD Oh, I would never ever, ever, ever do anything like that. I am not like that. I said, Okay, that's cool. said hey, let me tell you something. Do you know that before 1970 we were actually feeding animals like chickens and cattle. One of the primary things that we would feed them would be hemp, and it's been shown that you can take a chicken egg and it had over 250 milligrams of CBD, right so right now if you're somebody that just spent $200 on your CBD that has 300 milligrams in 1968 you could've just had an egg.A three cent egg.I know 3 cent egg. And I looked at the literature and I and I could not find anything that said death by egg otoxicity. It didn't so everybody that's sitting there thinking oh my gosh, no. I'm not going to do CBD. We were having CBD in our diet. A great Great example, to learn a lot more about this and do a deep dive. Our friend Chris kresser had Will Clyden and the CEO of O-hi, O-hi energetics on and he went into this tremendously. It was so cool. It was just like I just it's crazy that we stopped like, and I as a physician have seen that we are getting sicker as a country. So in 1970, we've got since 1970. We've got more chronic disease, we've got more dementia, we've got more autoimmune disease. coincidence, like we said in the intro, maybe it's at least a contributing factor. And now we have the FDA saying that CBD can be harmful yet it was in our food supply up until 1970.That's nuts, dude.It is nuts. And it doesn't make sense and if you look at mean hemp seed, birds eat seeds, birds consume seeds, they do all kinds of things where they can they take in product, What's the matter? No, I'm just looking at I'm trying to make sure we get through everything.Okay good, but I mean they eat everything and people have been consuming eggs from not just chickens they've been consuming eggs from all different birds on the planet for that long. The fact that we've restricted hemp growth etc has only taken away one of the natural things that birds were eating.If you're if you're really interested in this like I said go to Chris Cressors podcast where he's got Will Clyden on there is really cool wills smart dude Chris is super smart dude. So those guys those guys kick some crazy knowledge.Right?So that is it's weird that we're talking on this episode about CBD causing hepatotoxicity. And we've already shown that the liver's pretty badass, right? It can do a whole lot and we've already shown that the endocannabinoid system is necessary and since 1970, or up until 1970. We are taking in significant amounts of CBD in our dietRight.Weird.It is weird, but it's not so weird when we get down to why everyone's alarmed. So you want to get into a...Now let's go ahead and look at the studies. So that is sort of the phase one of this podcast because now we're going to start geeking out a lot. So I hope I didn't hope I didn't lose everybody with a but you kind of need that background to understand what we're going to talk about next.Sure, you definitely that background.Alright. So what they're talking about is the FDA published this revised consumer update. So this is the consumer update that they put out there for everybody detailing the safety concerns about CBD products. Now, this was based on the studies provided by GW Pharmaceuticals, GW Pharmaceuticals has done multiple different studies looking at different things to get their FDA approval. And I'm going to say right now, that kudos to GW for being the first company to step up and really try and make something for a group of people with intractable seizures have an alternative. Kudos to the FDA for doing their job and looking at the data that was presented to them. What I'm going to do is go next level and say, Well, you didn't look at everything. That's the bottom line here. So I'm not bashing anybody. Let's make let's make certain of this. Sure. So there have been several randomized, controlled and open label trials that studied the effects of epidolex, I'm going to call it epidolex from now on it's just easier, which is a 99% pure oral CBD extract on patients with refractory epilepsy. So this in turn led to the FDA approval for two diseases, dravet syndrome and Lennox-Gestaut syndrome. So if you recognize those names, bless you, because you're dealing with some serious stuff, It's a serious seizure issue. If you don't know those. Count your blessings. It's one of those times to go well, no matter where you're at in life. It's like well, thank goodness that I don't have to Deal with a child that has this because that's, that's a really big deal. These are intractable seizures. So they looked at the data on that. And in these studies, the kicker here is I'm going to say it again, getting back to the lane highway, the patients maintained on their stable drug regimen with a median of three anticonvulsant drugs. That's important. It's super important. Three anticonvulsant drugs. So when we use the analogy of the car on the road, imagine a six lane road. And three of those roads. Three of those lanes are double semis.Yeah, that are closed construction... Or closed, Yeah, that's more likely or closed. So let's talk about that. So when we're talking about three different agents used to control seizures, some of those agents would be and I'm assuming here, but probably Depakote, probably Dilantin, also known as phenytoin, or fosphenytoin, which is seravex. There's a handful of anti seizure medications and through my knowledge, all of them, all of them have been recorded as raising the enzyme levels used by the liver which of course would lead to ALT and AST elevation, showing that the liver is essentially working overtime to long term process these drugs right or wrong?Correct. Correct, which is exactly what the FDA is supposed to do. They're supposed to look at this data and go Okay, so let's just look at the study that they're talking about. So the FDA accumulated this data, and they looked at what GW presented GW presented in isolette of CBD, not a full spectrum. And the dose they ramped up to 20 mg's per kick 20 mg's per kick. What that means is a guy like me would take 1954 milligrams a day.That's a lot more...of CBD isolate. Now I see the effects, beneficial effects of taking KBMD health CBD 15 milligrams twice a day,that's 30 milligrams,that's 30 milligrams.The exact dose of what makes people feel better is very argued because all the data coming out of Israel shows that a lot higher doses, but I'm seeing effects at these doses So let's be real quick let's stop for context. So right now at this intersection what we're what you're saying is with a full spectrum and we said this at the beginning of the podcast that what GW Pharmaceuticals has with epidiolex is a CBD isolate and what they've done...You're saying epidiolex now that's funny. Yeah, whatever it is, Well, because I started with that. Then you told me no, that's not how you say it.I think we should switch it up the whole time. EPA max the way it was edimax. What they did is they were able to establish that almost 2000 milligrams for you would be the ideal dosage however, you...isn't that correct? That's the dosage that they went for or the dosage that they felt was safe, Safe. Okay, I'm sorry. So but but on the upper end of... That was what they were aiming for on everybody. In essence, though, from where you have had beneficial effects, you're talking 60 times that amount, two months worth, is what they are saying the safe level would be in one day where you're finding the beneficial spectrum. So just just in terms of context, full spectrum, CBD, one 60th of the dose that they're saying it's a it's a safe level is really all that you need from our experience.Yeah. Now in GW's defense, let's look at the data. So in dravet syndrome, seizures dropped 39% and in Lennox-Gestaut 42%. So... that's good. So they probably did their homework and said, well, we need to get up that high to actually help that so I don't know anything about that. I'm not a neurologist. That's where it's at. But I'm just saying that when we look at that dose, no average consumer is going to be able to consume that Much CBD in a single day, unless it comes through this 2 full grams a day is more than most take Yes,yeah. Now here's the problem 94% of the people had side effects. Okay 94% at the highest dose compared to 75% placebo, kind of weird. So there's just a huge placebo side effect profile that doesn't get discussed at all.Did they say what it just had a curiosity do they state with the placebo was for the control,They did not stay with the placebo was oh, I take that back. I don't know what they use, but basically they left people on the same medications. So, essentially, let's just look at this and say okay, but the good news is, most of it was not a big deal. Most of it was what the FDA also discussed beyond the liver tests and beyond the drug metabolism. They also said Oh, CBD can cause nausea. It can cause drowsiness. It can cause all these other kind of nuisance things. That's what they're referring to right here. It's interesting though, that have a side effect profile assigned to a placebo that's that exceeds around the 30% range, because that's generally the throwaway number. Yeah. So we've gone twice away from the throwaway number. And they've had they've had reported side effects, which I'm not trying to over draw conclusions here, but it could at least indicate that side effect profiles assigned to CBD in this study probably weren't solely to CBD, Well, you're dealing with one of the highest risk populations you can get your hands on, when I did clinical research and when we would do a moderate to severe Chron's study. The placebo arm would have tons of side effects because the disease is bad. That's what's going on here also. So most was not a big deal, upper respiratory tract infection, somnolence, decreased appetite, diarrhea, blah, blah, blah, blah, blah. But the one that they focused on is the increase in amino transferase concentrations. This once again was a revised consumer update, they put this out to the public and their statement is increase in liver amino transferase concentrations when I just got done explaining what the liver does. Did I ever say amino transferase concentrations? No. I said liver enzymes. right? frickin talk to the public if you're going to release a consumer paper. yeah, liver enzymes. AST ALT. This is hiding behind scientific garbaly goop. It's like you're doing half science half anyway. But but whatever. So a patient show up and they're like, I need you to check my amino transferase concentrations. I'm like, Whoa, why? They Hand me this, this, this news article. Right? This is what we're trying to address right here. So what they found is that in the higher dose, 20 mgs per kg, there was a rise in some patients in three times the level which is significant, so if your normal is 20. You can be 60 if your normal is 40 it can be 120. When patients come into me and it's three times the level it sounds alarming. Do you know what happens when somebody gets hepatitis A acute infection? It's way more than that thousands of times the level when somebody goes into foaming at failure there AST and ALT will go from 40 to 10,000.AST and ALT have risen for almost everyone who's listened here, way more than three times throughout their lifetime multiple times in acute or in very isolated settings. It happens with illness.So getting back to your highway analogy, which I think is really cool analogy. I'm glad you came up with that. Thank you .Getting back to the highway analogy. 80% of them were taking a drug called valproic it matters Depakote Yeah, that matters. That matters a lot.It's when you take these medications, which is why at the beginning of the show, I said you're more likely don't have to worry about it. But if you're on certain medications, keep it in mind. Now that being said at the lower dose didn't see this stuff. So there is a dose dependent usage of the P450 enzyme you can if I give you one drink, or if I give you a bottle of tequila 512 which in my opinion is really one of the tastiest, most fantastic tequilas you can ever get your hands on. It is delicious. It's delicious. I'm gonna I'm gonna digress right here. Oh my God, Tequila 512... Also sponsored by Tequila 512Tt was really good seriously, ummm in every single person with liver test rose.They went back to normal if they decreased the anticonvulsant or decreased the CBD. So either one it went back to normal. So it wasn't number one, it wasn't permanent liver damage. More than likely correct they were able to return back to normal. And number two, it was simply A case of an overwhelmed P450 pathway more more than likely.So you want to get really confusing? Not really but we might as well try. I don't want to but here's what's really interesting, then they kind of get a little geeky. So GW presented their their stuff and then they showed that the P450 in this enzymes and they went into will, the CYP to, 2c19 CYP three a four can inhibit the CYP blah, blah, blah. Those are all just cytochromes people. Those are all just cytochromes It's under the umbrella of P 450. That's how complex this is. Yeah,It is nuts how complex. The highest plasma concentration to CBD occurs within two to three hours after exposure to the Epidolex. With medication, so timing of these medications going to play a role, which actually got me down a weird rabbit hole where i started thinking. We haven't done this much analysis on what happens if you take your Ace inhibiter and you take your cholesterol medicine, timing wise PK analysis on different people and everything. Because when they do these pharmacokinetics, they do it to get the FDA approval, they do it on people that are healthy, that they can understand it. Let's put this into context again, if you're listening to this you've ever taken tagamet. Have you ever thought about when you take your tagamet, you probably only take it whenever you're afraid that you're going to have acid problems, right? Cimetidine?Yeah, guess what? It's also known as a high level p 450 inhibitor if it's over consumed. So I guess what I'm saying here is, there's probably way more alarms being driven over something that yes, is handled by the P 450 system, but is far less invasive or it's much it's a much smaller vehicle on this highway than some of the other things that the alarms are not sounding over.And then surprise surprise after I just got done talking about the liver and the genetic variability and all these other things. When they looked at the pharmacokinetics there was tremendous variation. Hmm. Weird. Yeah. Odd, right? So and anybody that's listening to this that is a, a pharmacist or is a scientist or like Well, yeah, duh. Like I know, duh. But why put out such an alarming statement? Yeah. Without context.Yeah, yeah, you're right. So it for Okay, so it's a little bit of clickbait stuff, right. And so maybe even the journalist who wrote it doesn't understand specifically, the implication, they may have only seen P450, written somewhere turned to a health care provider and said, What is this? Well, that's indicating that things are rising up, they freak out. They write a headline that says CBD causes liver failure. I just learned that from this health care provider. So I'm going to write this piece.Well, that we're going to get into that. The liver failure. This is still just the FDA. Oh, yeah. To the consumer. So I hope that the FDA looks at this and says, You know what? That's right. All that stuff that was just being said it's right. But we didn't have the time to do it. We couldn't sit there put that on paper, we'd lose everybody. I get it. It's quite true. We all we all but we all have a responsibility, much like any doctor to try and explain. You and I have this ability to have this forum to reach hundreds of trillions of people.Yeah. It eflects in our subscriptions on YouTube. They so many trillions of people subscribed, they started his back over to about 200. Yeah, so every time we got trillions, they start back over. Yeah. So So anyways, so what what you're realizing here is exactly what we're talking about. When you put stress on the liver. The liver honks its horn and does a little rise and the lfts goes, Well, hey, guys, maybe not so much. Can we just back off the traffic a little bit and see what's happening here. So additional studies have shown that levels of the anticonvulsant drugs actually caused the daily effects. So now we start wondering that the that the CBD may actually rise some of the anticonvulsants and then you have more side effects from that comes down to the same thing we're talking about how many things do you want to tax your liver, that's the bottom line. To summarize high dose of a pure CBD isolate, not full spectrum, while using a mean of three other anticonvulsants can cause temporary rise in liver tests and affect the metabolism slightly of the anticonvulsant. Of note, it did not happen at lower doses. So one more time, if you are on an anticonvulsant discuss with your doctor and make sure that you stay well below the 2000 milligrams a day. Yep. So this whole thing of Oh We're going to block the P 450 the P450 is So frickin complex, it is nuts. So anything you want to add to that, because I'm going to move on to the thing that I really want to, like kind of make fun of No, not really, I just want to say that I think that the FDA, unfortunately, is a very important and serious organization within our government. And I think that for all of the flack that they take their, unfortunately, with any other entity, there are limitations on what it is that they can do. And I do believe that they try their best to fairly ascertain and address situations as they are presented to them. Regardless of how frustrated that one of this may get is we don't get a result from them. A lot of it is just simply because there's not enough manpower. Oh, absolutely. They get thrown everything think about, think if you're in an organization where you know that 70% of the crap that's out there needs to be pulled off the shelves and you're limited. It's a government organization. These people making these statements are MD's. I'm really limited fortunately, I have well, we have the show where I kind of enjoy looking up some of this stuff. Fortunately, we have some friends of ours that are that work in the nutrition industry that are fantastic at researching articles. And some of that gets gets brought to me I want to make sure that we all get better this is the whole purpose of this.Hundred percent.I want to help the FDA and help GW I want to help the CBD industry. I want to help all of it. But let's just talk about this because something super weird happened. And this is the one that got the most press A Forbes article came out that promoted a mouse study and made the sensational claim that CBD causes liver failure.Yeah, that's kind of what I was referencing earlier. I may steal the thunder but yeah, you're right.Yeah, so this is you're exactly right. In the intro, you said it was clickbait. I really after looking at this study after pulling the study, because how many people read that article are actually going to pull the study.Well is the is the person who wrote this study that well versed in reading studies like that. I mean, that's that's an important thing. I mean, they I think that probably even the author of the article feels like that they are doing a service to the reader, but probably doesn't understand. And if they do, then shame on them, but if they don't, I think that would be a better explanation doesn't fully understand how to read the study and the quality and the qualifications of that study to make a statement like that.Yeah. And you know, this, this could be an arguable point, I'm sure that the person that that wrote this feels very strongly that what they said was right, the bottom line is the goal of this study was to investigate CBD cannabidiol hepatic toxicity, meaning liver issues in an eight week old male mouse. So they they took a group of eight week old male mice, and then they gave them a CBD that they produced. The CBD that they produced and Will Clyden will just jump up and down when he hears this because he decided Is this on Chris Cresser's podcast. The CBD that they produced was used to extract using hexane, which is a molecule that is known to be hepatotoxic. Yeah, you're not supposed to have heaxane. Don't do that! Will Clyden talked about the fact that if you find a CBD with an outrageously high amount of of CB, if you find a full spectrum CBD with an outrageously high amount of CBD more so and the price ranges, okay? Because what they did is they extracted that with hexane in a cheap way and threw it in their bottle and said, there you go. Now you can check that's got 10,000 milligrams of CBD or whatever. And it's really interesting because there's so much going on in the industry like this. So this particular study out of the University of Arkansas, took the CBD, or they made their own CBD using hexane which is a hepatotoxic in itself and in their certificate of analysis. It was there and then they gave it to these mice. Second thing neatI don't even know there has to be a second but we can hear it. Because I mean seriously, that's, that's like saying, I know your stomach hurts. You should take this Pepto bismol. And then I don't tell you that I've broken up some glass shards and have you drink it and you're like i'm bleeding now! What's going on? I'm like, I don't know. Yeah, but you only paid half the price.I made it myself.Which, by the way, that last batch of propophol that you did in your bathtub is working phenomenally. I'm sure it is. Now we do not make propophol in our bathtubs.Alright, so the second issue. If we have any mice that are subscribers to our show, or listening, I would like you to have your children removed from the room at this moment. Because they took these poor mice, and they gavaged to them. Would you mind defining what gavaged is? I think it's when you kind of force feed somebody I don't think it's willing. That's your I think gavaged something you kind of threw one at me there I think to gavaged someone you basically introduce a funnel to the esophagus and well you kind of get after it, don't you? Yes, I'm currently gavaging my mic right now trying to figure it out. I just undid everything. You're gavaging our ears with your, your microphone adjustments?All right, so gavage is they forcibly give these mice?The CBD extract? Yeah, I don't think it's comfortable nor pleasant.No typically through a tube feeding or down the throat to the stomach is how they generally gavage things. A quick side note, now because I'm now all of a sudden I feel like I'm living in a glass house when I was an undergraduate student. I actually did my first surgery on a rat and we took out their adrenal glands. And I'm just saying that so I don't want to sit there and pretend like I'm not done mean things to an animal. But that was when I knew immediately I could not be a bench researcher. I did not like that. At all, now I was like, I need to, I want to heal. I want to heal. I don't want to hurt these animals, but it's it's a whole separate discussion. So anyways, so they gavage these animals with different doses, and it's really interesting. Now in what they call their defense, they call it allometric dosing, which means they're trying to get the body weight to human weight ratio appropriate. I've read some rebuttals of this article where it is a joke, you just can't do that. And when I read vitamin weed Michelle Ross? Michelle Ross, when I read vitamin weed she dis... she specifically discusses why research on CBD versus mice is very difficult to do because the weight basing the endocannabinoid system is different, all these other things. So allometric dosing being said, assuming that they're saying it's right, so the dose would be the equivalent of what they gave and What a human would give So I'm doing the allometric dosing, which I think is actually higher than what it actually is separate thing. They took mice and they gavaged them with zero milligrams of hexane derived CBD 246 milligrams per kilogram 738 milligrams per kilogram or 2460 milligrams per kilogram of dirty CBD. It doesn't make sense dirty CBD isolate. So for instance, in a horrible alternate universe where humans are now the test subjects and we have large mice which are running tests on us, and they decided to gavage me with the same thing. That would be the equivalent at the highest dose of 241,080 milligrams of hexane derived CBD isolate. I'm not even sure what the hexane would do it 240,000 milligrams 242,000 milligrams.No I mean that being the more or less than now at this point, it's just an additive. It's just I mean it's it's not an excipient It's a straight up additive. That would not make sense at all. Oh, it's crazy.It's poison.This article came out in Forbes and said CBD causes hepatotoxicity. Also hexane causes hepatotoxicity.It is nuts. Alright, spoiler alert. The mice suffered hepatic toxicity and death at the highest dose. Shocking... You know what? I also hear it's bad to have breakfast cereal with not milk but drain-o. Just something that I'm gonna go out on a whim. Don't think you're supposed to do that. It just doesn't make sense. It's It's It's not. That is not an apples to apples comparison if you're talking Okay, so we talked about it earlier. reputable CBD source there is no reputable CBD producer that's going to have and Will special shout out to you it's going to have hexane as a byproduct or an excipient in their full spectrum COA approved which is also why KBMD Health with powered by olyxenol hundred percent is does not have that. I mean they do co2 extraction, which is the important thing which is a reason why we partnered with them to make that product. So we are the one out of the 23 or 24 that is the safe and trusted COA back no hexane etc etc. Doing this study is not an apples to apples comparison on what would happen because who knows? Who Okay, I don't get it because GW we already did that study. They determined that 20 Meg's per kg which is still a shit ton. It's a lot. It's a lot. Yeahis the safe maximum dose. These guys went times it by 100.Yeah, they did.And see what happens? Yeah, it's it's a bad it's a bad comparison. I mean, yeah, honestly, if you wanted to find out if CBD plus hexane causes liver toxicity at a ridiculous amount, top to bottom, then that's a great study outside of that, since nobody does it, I would say it's a bad study. Speaking of road, that's a road to nowhere.Yeah. And so study like this, uh, like you had mentioned is essentially it's not science. It's clickbait. Yeah. And right now that that author, that journalist is just kind of laughing. He's like, I know, and now you're bringing it up, and I'm going to get another whatever, because that's what people are trying to do. They're trying to get attention at this point.So at that point, good for you, you got to click but I would be truly interested if possibly that particular journalists would say, you know what, I didn't fully understand it. I mean, that's okay. Let's look reading studies, right? There's there's a study to reading studies. I mean, we heard that we heard the breakdown that kresser did on Joe Rogan is he Twice had to address his approach to completely different topic about the the plant based diet and then how he had to re approach that with the rebuttal. All that just simply to say, there is a science to reading studies and being really good at understanding what is and is not applicable and then how to find studies that you can compare to each other for good meta analyses. So what we're doing right now is I'm telling you that maybe sometimes there aren't studies, but my anecdotal evidence, I have a busy practice, you hear the patients, we hear them talk I listen to them, when they say that doesn't work. I go, Okay, I'm not publishing it. I don't have time to do that. I wish I did. If I published everything that we're gathering data on, if we're looking at, you know, just so many different things, CBD is just one of them. We've got I love I'm a huge fan of brain.FM for the ability to use sound to change your mood. I Would love to they're unpublished, a lot of studies on stuff like that. There's, there's tons of stuff. So when people go, oh, the studies aren't out there, there is something to be said about the Socratic method, or I'm sorry, the paternalistic method, the way that medicine used to be where the guy in front of you that saw thousands of patients, this is the method that he has. You see me scope, I mean, there's a difference in scope techniques.So they, although some may even still say it qualifies as anecdotal, I will say that there's objective data in both in a scope, somebody can't just come, anybody can come to you say I feel better. Anybody can even if they don't mean it. But they can't make the disease disappear from the imaging that we see in their colonoscopy, or the the mucosal samples that you take. And that's something that's completely objective data. That we see. So those are the everyday results that we see from these types of applications where you just, look it's not made up whenever we okay full pleasure when we first started looking at CBD, I thought was bullshit. Who you looking at?Just anybody who's out there. But when we first started talking about it, I didn't believe it. I was like, man, let's see, because we've been down this road before but we tried new, new without throwing a bunch of things under the bus. We tried new or innovative different things and high hopes. And unfortunately, low expectations and the expectations get met and the hopes are never never realized. The opposite for me personally occurred with CBD over the last three and a half years. And that is it actually stinking works.Dude, I knew that we were onto something with Atrantil, because after we did the initial studies, everybody came back and said, I want more. I knew that I was onto something or I was not on something. I knew that CBD had a viable place in my practice, because I bought and the story goes all the way back which is why we work with which is why it's powered by elyxenol right now, when we went to paleo FX, and I ordered a couple cases and I just gave them away to patients. That was not cheap. Not because I was sitting there trying to be altruistic, not because I was doing charity. I'm like, I don't know. I didn't. And I told everybody, I don't have a clue. I haven't even looked at this yet. All I know is try this. Tell me what happens. And when about 80% of them came back said I want more. And I went, Okay, we're onto something. And that's when I took my clothes off the deep dive into the science and went, holy cow. Yeah,this is crazyUp until that point, I just didn't know there was a whole lot to it. I mean, it really didn't. And then the fact is, oh, and to clarify, it's not like Brown just handed out CBD to just anybody who came to the clinic. You literally just like we did with Atrantil you found very diseased patients to say and who had gone through a gamut of different pharmaceuticals and weren't finding relief, and suddenly they're like, this is working for me. Tell me more about it. And I was, I was blown away.So let's talk a little bit. So we're I'm over here going well studies I haven't published and everything. Let's talk about a few studies. So I've got a Mendeley account, I know how to look at PubMed. I know how to get a Google Scholar, I just want to talk about a couple studies have come out recently. And let's kind of compare it and see if it still makes people concerned that they're going to die of liver failure.Sure. Alright. So in the Journal of Clinical Pharmacology published in 2019, the this was actually a study, also sponsored by GW Pharmaceuticals, as part of the process of getting the FDA approval that the FDA did not reference the best I can tell they did not reference this. This is way more complex and it gets super cool, because what they're looking at is the pharmacokinetics or how CBD is actually metabolized by that beautiful genius called a liver. In high doses in people with liver disease. Yeah, they went through the trouble to take high doses of CBD and give it to people People that did not have liver disease had mild liver disease moderate and severe. This was ballsy to say the least, because using a product like this in somebody with liver disease is is risky. This thing could backfire and it could shut down the whole process. Here's what's nuts, the pharmacologic and safety of a single oral dose of 200 milligrams of epidolex, which is the CBD isolate. They were assessed in subjects they had eight people with moderate or with mild disease, six people with moderate and eight people with severe and then they had this collection of normal people. Blood samples were collected to check for the pharmacokinetics This is how drugs are looked at. They give you a drug and then they check your levels. Basically, the blood concentration was higher in the hepatic impairment and they describe it in nanograms. So the nanogram comparison is that it's a little bit higher in those with severe hepatic impairment. But this is what's nuts there was no increase in adverse reactions. There was no change in blood levels. So basically, the only adverse reaction that they found was a little bit of diarrhea. And it all happened in the mild hepatic impairment. So the FDA had mentioned Oh, studies have shown that it causes diarrhea. What was really funny about

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¿Cómo funciona el gestor de referencias Mendeley? Julio Alonso Arévalo

Transmedia

Play Episode Listen Later Aug 27, 2019 0:56

Comunicablos Transmedia Esteban Galán En Twitter, Facebook e Instagram somos ¡¡¡Síguenos!!! Eres uno de nuestros Selectos Pabellones Auditivos... ¡¡Dale a Like y suscríbete a Transmedia para que podamos seguir disfrutando juntos de este café con micro!! Comunicablos Transmedia. Encapsulamos ideas para imaginar el futuro

funciona gestor valo referencias transmedia mendeley julio alonso

Inside (Publishing) Baseball [Idea Machines #12]

Idea Machines

Play Episode Listen Later Mar 12, 2019 36:30

In this episode I talk to William Gunn about the guts of science publishing, changing incentives in science, and the relationship between publishing and funding. William is currently the Director of Scholarly Communication at Elsevier. He joined Elsevier when they acquired Mendeley, which is a platform designed to help researchers share papers and notes about them. Before that he was an academic researcher himself and, for a time, a professional chef. Key Takeaways Science publishers aren't idiots - they realize that the internet is making anything free that can be free and are trying to adjust their business models accordingly. The metrics we use to judge research innovation are starting to shift and interestingly that is speeding up the "speciesation" of fields. Science has shifted more towards "big science" - big teams with big funding doing big experiments. However, there may be room to discover many more things if we put more focus on smaller projects. Resources William on Twitter @MrGunn Mendeley - a platform for sharing science Are Ideas Getting Harder to Find? Diminishing Returns from Science

How to beat digital distraction and write more episode 11 - How to reference your research well

How to Beat Digital Distrations

Play Episode Listen Later Feb 27, 2019 5:14

In this short series of podcasts I want to help you be more productive with your writing and help you get things done. In this podcast I want to discuss the kind of things that will help your writing process be that little more ordered and less painful.

research digital write distractions mendeley research skills

Episode 20: Behind the Paper

Byte.Coffee

Play Episode Listen Later Oct 30, 2018 48:02

Support our show 坐在 Mac 背后写论文 Outline 起因写作工具 WYSIWYG 所见即所得 Word WYSIWYM 所见即所思 LaTeX 语言本地工具 LyX 在线工具 Overleaf 纯文本编辑器，Sublime Text，Ulysses，MWeb 文献管理工具 EndNote Zotero Mendeley 绘图工具 Basic Concepts 位图 Bitmap：BMP，PNG，JPG，TIFF 矢量图 Vector Image：EPS，WMF，EMF，SVG 原理图表示运行机理 MS Word Microsoft Visio Edraw 学术绘图 Illustrator 艺术设计类 Solidworks 适合于工程类应用 Procreate 抠图修改证件照背景色 MWeb 绘制流程图数据分析类 Python matplotlib Matlab LaTeX R Perl Krona 绘制好看的基因图 My personal setup and workflow 写作 Word MWeb Ulysses Overleaf Sublime Text MathType MathJax 绘图 Edraw Procreate Matlab 文献管理：EndNote X8 差劲的论文投稿系统 Links Byte Coffee Ulysses App MWeb LyX Overleaf OSA Journal 的模板 Sublime Text 少数派文章：搭建 Ulysses 学术写作之公式输入 EndNote Zotero Mendeley Zotero VS EndNote How to Choose: EndNote, Zotero, or Mendeley 少数派文章：纯文本+ EndNote + Word 处理参考文献少数派文章：如何处理参考文献 Visio Edraw Adobe Illustrator 知乎：矢量图存在的意义是什么 Automotive illustration by KHI, Inc. 穆夏—欧洲新艺术运动瑰宝 Solidworks AutoCAD Procreate 用 Procreate 修改证件照背景颜色 MWeb 绘制流程图如何在论文中画出漂亮的插图 Krona Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization Applying Customer Feedback: How NLP & Deep Learning Improve Uber's Maps Example: Polarizing microscope Software to draw the diagrams in the papers A vector graphics library for illustrations of optics experiments MathJax Prism Host MilkShake羊 Sound Editor Kalaokay Contact 网站：http://Byte.Coffee/ 邮箱：hi@Byte.Coffee 新浪微博/Twitter/Instagram：@ByteCoffee Slack 听众群 Support Byte.Coffee

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MA09: Offene Forscher sind erfolgreicher

MERTON Audio

Play Episode Listen Later Aug 15, 2018 10:27

Mit seinem Berliner Start-up ResearchGate sprengt Ijad Madisch die Grenzen der Wissenschaft. In dem Netzwerk sollen Wissenschaftler künftig Erfolge wie Fehlschläge bereits in einem frühen Stadium der Forschung teilen können. ResearchGate wurde 2008 gegründet. Unter den drei großen Wissenschaftsnetzwerken im Web, zu denen auch Academia.edu und Mendeley zählen, gilt das Berliner Start-up laut einer Umfrage des Magazins „Nature“ als das aktivste seiner Art. Mit derzeit rund zwölf Millionen Nutzern verzeichnet ResearchGate nach eigenen Angaben ein starkes Wachstum. (Autor: Lukas Grasberger)

Episode 51: Sommerprojekt: Find et godt research-værktøj

work.flow - med Anders Høeg Nissen

Play Episode Listen Later Aug 9, 2018 38:22

Jeg kan jo godt lide systemer, struktur og overblik - og jeg har i mange år været på jagt efter værktøjer, der kan hjælpe, uden dog nogensinde at finde det helt rigtige. De primære behov er noget med at kunne samle links, artikler og pdf’er, organisere og strukturere samlingen, lave highlights og noter i dem, og så også gerne kunne dele eller eksportere de highlights til de apps, jeg så skriver i. I denne sommer har jeg taget endnu en tur, og set på adskillige håndfulde tjenester og apps, uden dog at være blevet helt tilfreds. Det fortæller jeg om i denne lidt specielle episode, hvor jeg selv er gæst… Og husk - har du tips om apps jeg ikke har nævnt (eller hvis du har fundet features, jeg åbenbart har overset), så sig endelig til! Det samme gælder naturligvis, hvis du mener du rent faktisk kan lave præcis det værktøj, jeg har behov for

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EZ - IO Part Deux

Play Episode Listen Later Aug 5, 2018 25:59

Dr. Stilley delivers a follow-up discussion to the EZ-IO Shorty. We take a more in-depth exploration of humeral IO placement. Catch the show notes at: http://cbcemp.proboards.com/thread/96/ez-io-deux Articles can also be found at Mendeley. http://www.mendeley.com Make a free account and then request an invite!

io mendeley

Narcan Part 2

Play Episode Listen Later Jul 16, 2018 15:42

We are back with Part 2 of Dr. Stilley's discussion of Narcan! Check out the articles at Mendeley: www.mendeley.com/ by joining and requesting an invite from cbcemp.foamed@gmail.com Catch all the show notes: cbcemp.proboards.com/thread/95/narcan

narcan mendeley

Narcan Part 1 - TMDAR

first responders narcan mendeley

Play Episode Listen Later Jul 12, 2018 15:05

Dr. Stilley is back! Next on the agenda is his response to First Responder and layperson Narcan as well as healthcare provider usage of Narcan. Check out the articles at Mendeley: https://www.mendeley.com/. After you make an account, email cbcemp.foamed@gmail.com for an invite! Catch all the show notes: http://cbcemp.proboards.com/thread/95/narcan

Delirium Tremens

Karrierebooster Netzwerke(n)

Play Episode Listen Later Jun 21, 2018 16:43

Protocol Breakdown is back! This week's episode is all about DT's and alcohol withdrawal. This topic was by special request. If YOU have an idea for a show, send it to cbcemp.foamed@gmail.com Sources for this podcast and all future episodes are now available at Mendeley. You do have to have an account to play, but you can get all the articles and research papers directly on your device! Join the group at: Check out the articles at Mendeley: https://www.mendeley.com/. After you make an account, email cbcemp.foamed@gmail.com for an invite! Catch the show notes at: http://cbcemp.proboards.com/thread/94/episode-14-delirium-tremens Music: "Like Swimming" by Broke for Free, From the Free Music Archive, CC BY NC 3.0

broke dt free music archive cc by nc delirium tremens mendeley like swimming

(Online-)Netzwerke für Wissenschaftler*innen [019]

Play Episode Listen Later Jan 26, 2018 22:13

Wer sich als Wissenschaftler*in nach beruflichen (Online-)Netzwerken umschaut, findet zahlreiche Angebote. ResearchGate, Academia.edu sowie Mendeley gehören in Deutschland zu den bekanntesten und am meisten genutzten. Welche Features diese gerade für den wissenschaftlichen Nachwuchs bieten und wie sich eine sinnvolle Auswahl treffen lässt, zeige ich in dieser Episode. Und auch wenn sich abzeichnet, dass es mit der Wissenschaftskarriere nichts wird, gibt es Möglichkeiten, den Wechsel in die Wirtschaft strategisch vorzubereiten. Shownotes: Auf dem Portal wissenschafts-thurm.de können sich Studierende über wissenschaftliches Arbeiten sowie Arbeiten in der Wissenschaft informieren, inklusive der "Grundlagen der Statistik" sowie einer Übersicht über Förderprogramme. Der Ton ist locker und die Seite lässt sich daher gut nutzen. Wer mehr über den Einstieg und eine Karriere in den Naturwissenschaften wissen möchte, ist bei naturalscience.careers gut aufgehoben. Von den gleichen Autor*innen Karin Bodewits, Philipp Gramlich, Andrea Hauk ist das Buch "Karriereführer für Naturwissenschaftlerinnen. Erfolgreich im Berufsleben" bei Wiley-VCH/2015 erschienen. Artikel: Ich bin ziemlich viel an Universitäten und Hochschulen unterwegs und spreche in dem Zusammenhang bei Vorträgen oder in Workshops über das Thema "Netzwerken". Dabei habe ich mit Absolventinnen und Absolventen, aber eben auch mit Promovend*innen oder Postdocs, also Wissenschaftler*innen, zu tun. Dabei geht es oft um die Frage, wie ich Netzwerken in der Wissenschaft so nutzen kann, dass ich mich auf meinem Berufsweg so weiterentwickle, dass ich am Ende einen Ruf auf eine Professur bekomme. Oder, was ja auch durchaus sein kann, dass ich mir einen Jobeinstieg nach der Wissenschaftskarriere suche. Wer wissenschaftlich arbeitet, findet natürlich die gängigen Netzwerke, die wir sonst auch kennen. Es gibt natürlich durchaus die Möglichkeit, sich auch in den beruflichen Netzwerken zu tummeln, also bei LinkedIn, bei Xing oder auch bei Facebook. Für Wissenschaftler*innen gibt es ein paar andere Gegebenheiten. Dafür sind entsprechende Netzwerke entstanden, die dem Rechnung tragen. Weiterlesen

Tech Edge, Mobile Learning In The Classroom - Episode 32, Research and Citation, Part 2

Tech EDGE - For Teachers

Play Episode Listen Later Oct 3, 2016

Technology Information: Research and Citation - Citation Machine, Google Docs, Mendeley and Cite This For Me

research classroom google docs citation mobile learning mendeley tech edge

Tech Edge, Mobile Learning In The Classroom - Episode 32, Research and Citation, Part 2

Tech EDGE - For College Students

Play Episode Listen Later Oct 3, 2016

Technology Information: Research and Citation - Citation Machine, Google Docs, Mendeley and Cite This For Me

research classroom google docs citation mobile learning mendeley tech edge

GeekGirl Meets Rosario Garcia de Zuniga, CTO & Co-Founder of Headliner

GeekGirlMeets

Play Episode Listen Later Jan 27, 2016 34:00

GeekGirl was excited to sit down with Rosario, CTO and Co-Founder of Headliner, in the third episode of GeekGirl Meets. See her bio below! Rosario is the co-founder and CTO of Headliner.io, a marketplace connecting live musicians, bands and DJs with amateur and professional bookers in the private events space. Headliner just graduated from the Techstars London 2015 cohort, where Rosario was the first female CTO to go through the London program. Deeply passionate about software architecture, testing, and design; building resilient, scalable systems is a skill which she’s honed from years of hands-on experience. Prior to embarking on her own venture, Rosario was working at Mendeley, a social network for researchers, which she helped growing from a very early stage right until after its acquisition in 2013. There she led the core API and Web development team and helped transition Mendeley to an open platform. In her free time she enjoys running, yoga, playing the piano and dancing. And she can’t wait until she has some time to go scuba diving. Links mentioned: https://www.codecademy.com/ http://stackoverflow.com/ http://twitter.com/phpeach Other links on where to learn how to code online: https://www.reddit.com/r/learnprogramming/comments/3k2ehq/codecademy_vs_free_code_camp_vs_code_school_vs/

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ScHARR Learn Hacks #9 Mendeley

ScHARR Learn Hacks

Play Episode Listen Later Jul 27, 2015 2:12

Using Mendeley for productivity, curation, discovery, collaboration, impact, transferable skills

hacks mendeley scharr

ScHARR Research Hacks #3 Mendeley

ScHARR Research Hacks

Play Episode Listen Later Apr 14, 2015 1:02

How setting up a Mendeley account can help you discover other's research and help promote your own

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Mendeley App Tutorial

Apps for Higher Education

Play Episode Listen Later Apr 14, 2015 1:31

Explains the basics of Mendeley app and how it can be applied within HE.

tutorials mendeley

PaperShip App Tutorial

Apps for Higher Education

Play Episode Listen Later Apr 14, 2015 2:02

Explains the basics of PaperShip app and how it can be applied within HE. PaperShip app gives access to your Mendeley library.

tutorials mendeley

Technology to Make Med School Easier

The Short Coat

Play Episode Listen Later Mar 12, 2015 49:52

We need validation. Leave a review: iTunes | Stitcher Medical School is hard work. Between the information to memorize and the concepts to understand, along with the time you'll spend on it all, it seems ripe for technological intervention. Can an app really help you memorize anatomy? Can a website really help you make medical decisions? Can a table really help you get organized? We recently surveyed students here at the UI Carver College of Medicine and on Reddit, asking them for recommendations and tips on using tech during medical school. Listen in as Cole Cheney, Aline Sandouk, John Pienta, Lisa Wehr, and Greg Woods wade through the results. While there are certainly plenty of apps out there to try, in general the info we got boiled down to a few major app winners and platform leaders, and some others to try, too. Because what it all comes down to is there's more than one way to study medicine, and you'll just have to try them to see which one is best for you. For seasoned med students these apps and sites will be familiar. For those who' are looking f or alternatives, our discussion may help. Popular: Taking notes Notability iAnnotate Also try: Evernote Popular: Studying Anki VitalSource Also try: Osmosis. More info… Firecracker. More about the SuperMemo algorithm… Popular: Productivity Dropbox Google Drive/Docs/Cal/etc. Also try: iStudiez Teux Deux Coffivity Popular: Supplemental Info UpToDate Wikipedia Google Netter's Anatomy Atlas Also try: Eponym Mendeley Picmonic Sketchy Micro Popular: Clinical Micromedex Epocrates Calculate Also try: The Papp App Your Hosts This Week: [huge_it_gallery id=”21″] Listen to more great shows for medical students on The Vocalis Podcast Network. The opinions expressed in this feed and podcast are not those of the University of Iowa or the Roy J. and Lucille A. Carver College of Medicine; nor do they reflect the views of anyone other than the people who expressed them...

Food Safety Talk 64: The One With Doug

Food Safety Talk

Play Episode Listen Later Aug 28, 2014 84:44

In a special episode recorded back before Ben went on summer hiatus, the guys invite Doug Powell on for a chat. According to Wikipedia (which is never wrong), Dr. Douglas Powell was raised in Brantford, Ontario (that's in Canada). Doug describes himself as a former professor of food safety and the publisher of barfblog.com. He is passionate about food, has five daughters, and is an OK goaltender in pickup hockey. These days Doug is been thinking a lot about soul, and given the Venn diagram of their intersecting musical tastes this leads to a discussion of Mr. Soul and a place where even Richard Nixon has got soul. Any discussion of music and soul leads to a mention of the classic Soul Man, which Don knows from the Blues Brothers movie, and Doug knows from the original version by Sam and Dave. Doug is thinking about soul because of his monthly writing gig for the Texas A&M Center for food safety. The piece he was ruminating on during the call led to a post called "It's Gotta Have Soul" where his central thesis is that most people talking about food safety lack relevance; they lack soul, and fail to resonate. After the guys bid Doug good night, the discussion turns to managing graduate students, task tracking software like OmniFocus, distracting diversions like Flappy Bird, managing references using Sente or Mendeley and a brief look forward to this special events which are coming, or rather were coming, at the IAFP annual meeting.

canada soul ontario wikipedia richard nixon sente venn blues brothers flappy bird soul man brantford omnifocus doug powell mendeley food safety talk

PhD 012: Tools, Tips, and Strategies to Increase Your Productivity (Part 1)

PhD (in Progress) Podcast | Education, Career, Life

Play Episode Listen Later Jul 9, 2014 53:06

Click here to subscribe and rate us in iTunes | Or Subscribe on Stitcher This week Jason, Nikhil, and Kelly discuss productivity resources that have worked for them in their graduate studies. For more information, visit our blog entry on Productivity Web Tools for Graduate Students. There is more information on Mendeley, Papers, Google Calendar, and Mint. Resources Mentioned and […]

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Keeping your desktop tidy Mendeley-style

Quantum Tunnel Podcast

Play Episode Listen Later Nov 29, 2013 11:38

style desktops tidy mendeley

Mentén tu escritorio limpio al estilo Mendeley

Quantum Tunnel en Español

Play Episode Listen Later Nov 27, 2013 12:57

Mentén tu escritorio limpio al estilo Mendeley Noticias: - Asteroides cerca de la Tierra - Perdida de Memoria - Elefantes ahuyendatos por hormigas - El joven de Chal Hol

ment estilo limpio escritorio mendeley

BB49: Mendeley with William Gunn!

Breaking Bio

Play Episode Listen Later Nov 21, 2013 27:08

In episode 49, we talk with William Gunn (@mrgunn), Head of Academic Outreach at Mendeley! We chat with him about Mendeley, replicating studies, open access, and Elsevier. Did you #mendelete? One of the hosts did! Come see us dish out the hardhitting journalistic questions for which our podcast is not at all famous.

head gunn elsevier mendeley

Minute Mendeley - What is Mendeley

Play Episode Listen Later Nov 18, 2013 5:32

This video provides an introduction to the Mendeley reference managing software, gicing an overview of its key features and quick introduction to its use.

mendeley

Minute Mendeley - Searching the Mendeley Database

searching databases mendeley

Play Episode Listen Later Nov 8, 2013 2:20

How to find papers within the Mendeley database of papers that have been contributed by its huge community of users.

Minute Mendeley - Adding your own Publications

Play Episode Listen Later Nov 8, 2013 1:59

How to add your own publications to your profile so that they are visible to the wider Mendeley user community.

publications mendeley

Minute Mendeley - Tagging

Play Episode Listen Later Nov 8, 2013 2:13

How to use tags to help manage your collection of references and papers.

tagging mendeley

Minute Mendeley - drag and drop PDF

Play Episode Listen Later Nov 8, 2013 1:22

How to add a PDF to your to your collection of references and papers in Mendeley using drag and drop.

drag and drop mendeley

Minute Mendeley - How to Add Files Manually

Play Episode Listen Later Nov 8, 2013 1:58

How to manually add a reference to your collection of references and papers in Mendeley

files mendeley

Minute Mendeley - Annotating PDFs