Podcasts about adaptor

Accessory for adapting or connecting two devices or two workpieces

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Best podcasts about adaptor

Latest podcast episodes about adaptor

Crossing Thin Ice
Adaptor - A Vital New Business Role

Crossing Thin Ice

Play Episode Listen Later Dec 17, 2024 18:56


The future belongs to those who learn to adapt. In this, the 48th episode of Crossing Thin Ice, Dave Ingram and Max Rudolph dive into the importance of adaptability in modern business. Explore how the new Adaptor role will help companies to anticipate challenges, leverage opportunities, and embed resilience into every decision.

Respect the Process
AI Storytelling From An Early Adaptor's Point of View, Filmmaker Jon Finger, Part Two.

Respect the Process

Play Episode Listen Later Jul 2, 2024 53:19


The conclusion to my fascinating chat with Filmmaker Jon Finger, my guru of AI filmmaking tools, discusses their impact on the creative industries from the perspective of an early adopter. While acknowledging tools like image generation raise valid concerns, Jon believes AI can empower independent artists by lowering barriers to distribution. Jon shares experiences experimenting with AI storytelling but finds human connection vital. He stresses respecting one's creative process over shortcuts. We chat about AI-assisted editing, generative content, and licensing issues for visual creators. The take away is hopeful: AI can supplement but cannot replace human creativity or the fulfillment found through disciplined craft. Thanks Jon for a great chat.  FILMMAKER RETREAT JOSHUA TREE 2024 - SIGN UP! Our 3rd annual Filmmaker Retreat Joshua Tree is Thursday, September 26th – Sunday, September 29th, 2024. I always use the word "transformational" in describing the past two years - because our tribe of like-minded filmmakers express that the retreat truly changed their lives. Both professionally and personally. Reserve your spot before the end of the year to take advantage of that last minute 2023 write-off. Limit 20 Filmmakers. FLOW Use the link plus code JB20 when you try https://www.magicmind.com/jordanbrady chug it daily after your coffee. If you follow me on Instagram you know my geniune endorsment of this mighty mind power juice. Check out my Masterclass or Commercial Directing Shadow online courses. (Note this link to the Shadow course is the one I mention in the show.) All my courses come with a free 1:1 mentorship call with yours truly. Taking the Shadow course is the only way to win a chance to shadow me on a real shoot! DM for details. How To Pitch Ad Agencies and Director's Treatments Unmasked are now bundled together with a free filmmaker consultation call, just like my other courses. Serious about making spots? The Commercial Director Mega Bundle for serious one-on-one mentoring and career growth. Here's the Lbb Director's Playbook article sharing my pitch secrets. And my follow up that came out this week, How To Write Winning Treatments.  4+ NEW BEHIND-THE-SCENES I've uploaded more raw behind-the-scenes, with dailies, agency interaction, directing top talent and collaborating with my crew, all at Commercial Directing Masterclass. And you'll wanna check out the new courses, like Behind The Beard and Winning Director Treatments. Thanks to our editor Jake Brady We could not do the show without him and love this guy behind words. Need your pod spruced up? Check out his Podcast Wax. Thanks, Jordan This episode is just about 54 minutes. My cult classic mockumentary, “Dill Scallion” is online so I'm giving 100% of the money to St. Jude Children's Hospital. I've decided to donate the LIFETIME earnings every December, so the donation will grow and grow. Thank you. Respect The Process podcast is brought to you by Commercial Directing FIlm School and True Gentleman Industries, Inc. in partnership with Brady Oil Entertainment, Inc.

Down the Yellow Brick Pod
Slipperhood: Brooke Jorden (Adaptor of "Lit for Little Hands: The Wonderful Wizard of Oz")

Down the Yellow Brick Pod

Play Episode Listen Later Jun 30, 2024 68:01


Tara and EmKay are joined by Brooke Jorden, Editorial Director at Familius, to discuss the new addition to the Lit for Little Hands Series, her adaptation of "The Wonderful Wizard of Oz"! Brooke shares her journey into the world of publishing, the process of adapting Oz into an activity board book for young readers, working with her illustrator Olga Skomorokhova, and so much more!Find this beautiful book in a store near you beginning July 9th, 2024.Show Notes:Lit For Little Hands - Familius@familiusbooksHannah Isabel LewisJen's Pretty PegsInstagram: @downtheyellowbrickpod#DownTheYBPTara: @taratagticklesEmKay: www.emilykayshrader.netPatreon: https://www.patreon.com/downtheyellowbrickpodEtsy: https://www.etsy.com/market/down_the_yellow_brick_podMusic by: Shane ChapmanEdited by: Emily Kay Shrader

NHR Sunday Morning Local Arts
Andrew Whittle, Director and Adaptor of Here And There's production of "Hedda"

NHR Sunday Morning Local Arts

Play Episode Listen Later Mar 24, 2024 10:40


Andrew Whittle, Director and Adaptor of Here And There's production of "Hedda" at the Nottingham Arts Theatre chats to Kev Castle on Nottingham Hospitals Radio.

Authentic Biochemistry
BioMedical Portrait VIII.c.3. Leukotriene molecular speciation involves subcellular re-distribution of modifying enzymes and adaptor proteins associating with ER and Nuclear membranes.DJGPhD.28.12.23

Authentic Biochemistry

Play Episode Listen Later Dec 29, 2023 29:59


References Infect Immun. 2021 Aug; 89(8): e00095-21. Eur J Immunol. 1992 Oct;22(10):2705-11 Progress in Lipid Researc 2015. hVolume 57, January Pages 13-39 Am J Physiol. 1999 Apr;276(4):C988-94. Beethoven, L. 1813, 08 December.: Symphony no. 7 in A major, op. 92. https://youtu.be/T7CjuvE8oFA?si=il248jF2v7njd-Jo --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Jumping The Shuttle
84: "Hot Wheels"

Jumping The Shuttle

Play Episode Listen Later Jul 20, 2023 74:12


Why do the vibes INSTANTLY change when we record at night? Who's in charge of putting the numbers on these episodes? And what big, bloated industry are we bailing out this week? We rev up the answers to these questions and more as we watch Season 4, Episode 12 of Family Matters.Alex Diamond, David Kenny, and John McDaniel heard that the long-running network sitcom Family Matters ends with side character Steve Urkel going to space. And the best way to figure out how that happened - obviously - is to watch the last episode first and make our way backwards through nearly ten years of television.Join our countdown to number one (and our slow descent into madness) in all the places you expect internet people to be:Website: jumpingtheshuttle.spaceEmail: jumpingtheshuttle@gmail.comInstagram: @JumpingTheShuttle / @ThatAlexD / @dak577Twitter: @JumpingShuttle / @ThatAlexD / @dak577TikTok: @JumpingTheShuttle / @ThatAlexD / @dak577Brought to you by Smooth My Balls

Authentic Biochemistry
ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry

Authentic Biochemistry

Play Episode Listen Later Jul 11, 2023 29:16


References Nature Immunology 2022. volume 23, pages 1208–1221 Signal Transduction and Targeted Therapy 2021. volume 6, Article number: 412. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

PaperPlayer biorxiv cell biology
Active zone protein SYD-2/Liprin-α acts downstream of LRK-1/LRRK2 to regulate polarized trafficking of synaptic vesicle precursors through clathrin adaptor protein complexes

PaperPlayer biorxiv cell biology

Play Episode Listen Later Feb 26, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.26.530068v1?rss=1 Authors: Nadiminti, S. S. P., Dixit, S. B., Ratnakaran, N., Hegde, S., Swords, S., Grant, B. D., Koushika, S. P. Abstract: Synaptic vesicle proteins (SVps) are thought to travel in heterogeneous carriers dependent on the motor UNC-104/KIF1A. In C. elegans neurons, we found that some SVps are transported along with lysosomal proteins by the motor UNC-104/KIF1A. LRK-1/LRRK2 and the clathrin adaptor protein complex AP-3 are critical for the separation of lysosomal proteins from SVp transport carriers. In lrk-1 mutants, both SVp carriers and SVp carriers containing lysosomal proteins are independent of UNC-104, suggesting that LRK-1 plays a key role in ensuring UNC-104-dependent transport of SVps. Additionally, LRK-1 likely acts upstream of the AP-3 complex and regulates the membrane localization of AP-3. The action of AP-3 is necessary for the active zone protein SYD-2/Liprin- to facilitate the transport of SVp carriers. In the absence of the AP-3 complex, SYD-2/Liprin- acts with UNC-104 to instead facilitate the transport of SVp carriers containing lysosomal proteins. We further show that the mistrafficking of SVps into the dendrite in lrk-1 and apb-3 mutants depends on SYD-2, likely by regulating the recruitment of the AP-1/UNC-101. We propose that SYD-2 acts in concert with both the AP-1 and AP-3 complexes to ensure polarized trafficking of SVps. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Cancelled Culture TODAY
The Skwert Douche Adaptor Kit by BoneYard Sometimes bulbs or showers aren't easy to come by. Water bottles, on the other hand

Cancelled Culture TODAY

Play Episode Listen Later Jan 6, 2023 0:32


Spor 2
Radio Z Podkast 9 desember 2022 Juletilbud fra Adaptor, Hjemmekontoret, tilbud der du bor og dagens aviser

Spor 2

Play Episode Listen Later Dec 9, 2022


Cloud Native in 15 Minutes
The Vibe at Cloud Foundry Day

Cloud Native in 15 Minutes

Play Episode Listen Later Nov 14, 2022 39:18


What's going on in the Cloud Foundry community? In this episode, Ben and Coté are joined by Nick Kuhn (a return guest!) to talk about the recent Cloud Foundry Day at KubeCon. They discuss Cloud Foundry on kubernetes, build packs, Detroit pizza, and singing the hits of the day back in the late 80s. Mentioned: The Application Service Adaptor to wire up Cloud Foundry with kubernetes. Nick's demo of the Adaptor. Recordings of talks from Cloud Foundry Day, 2022. The Tanzu Application Service, VMware's Cloud Foundry distro. You can watch the original video recording if you prefer that.

Cloud & Culture
The Vibe at Cloud Foundry Day

Cloud & Culture

Play Episode Listen Later Nov 14, 2022 39:18


What's going on in the Cloud Foundry community? In this episode, Ben and Coté are joined by Nick Kuhn (a return guest!) to talk about the recent Cloud Foundry Day at KubeCon. They discuss Cloud Foundry on kubernetes, build packs, Detroit pizza, and singing the hits of the day back in the late 80s. Mentioned: The Application Service Adaptor to wire up Cloud Foundry with kubernetes. Nick's demo of the Adaptor. Recordings of talks from Cloud Foundry Day, 2022. The Tanzu Application Service, VMware's Cloud Foundry distro. You can watch the original video recording if you prefer that.

Bandwidth Conversations
Dangerous Liaisons: A conversation with Sir Christopher Hampton, award-winning playwright, screenwriter, translator, adaptor, director and lyricist.

Bandwidth Conversations

Play Episode Listen Later Aug 23, 2022 54:40


Sign up to our newsletter and never miss a release! | Visit our website Sir Christopher Hampton is a playwright, screenwriter, translator, adaptor, director and lyricist. He is an Oscar and Tony Award winner. His French teacher described him as “quite simply one of the most brilliant students I ever taught”. Among many things, Sir Christopher talks about his formative years in Alexandria, making theatre history by being the youngest playwright to have a West End hit at the age of 20, writing “Dangerous Liaisons” and winning the Oscar, writing the screenplay of “Atonement”, translating and co-writing “The Father” and his acting role alongside a young Leonardo DiCaprio as the judge in “Total Eclipse”. Related Links and reading Dangerous Liaisons trailer Atonement trailer The Father trailer Carrington trailer Total Eclipse trailer Read: White Chameleon by Christopher Hampton

Karen Hunter Show
Jane Elliot - Adaptor of the Blue Eyes Browns Exercise in discrimination

Karen Hunter Show

Play Episode Listen Later Jul 13, 2022 40:48


Papers Read on AI
Learning Multiple Stock Trading Patterns with Temporal Routing Adaptor and Optimal Transport

Papers Read on AI

Play Episode Listen Later Nov 29, 2021 35:20


Successful quantitative investment usually relies on precise predictions of the future movement of the stock price. Recently, machine learning based solutions have shown their capacity to give more accurate stock prediction and become indispensable components in modern quantitative investment systems. However, the i.i.d. assumption behind existing methods is inconsistent with the existence of diverse trading patterns in the stock market, which inevitably limits their ability to achieve better stock prediction performance. In this paper, we propose a novel architecture, Temporal Routing Adaptor (TRA) 2021: Hengxu Lin, D. Zhou, Weiqing Liu, J. Bian https://arxiv.org/pdf/2106.12950v2.pdf

Spor 2
Radio Z Podkast 05. november 2021

Spor 2

Play Episode Listen Later Nov 5, 2021


Adaptor presenterer nye medlemstilbud. Tilbud der du bor. Hjemmekontor med May Nina og Aage. Dagens aviser.

Spor 2
Radio Z Podkast 05. november 2021

Spor 2

Play Episode Listen Later Nov 5, 2021


Adaptor presenterer nye medlemstilbud. Tilbud der du bor. Hjemmekontor med May Nina og Aage. Dagens aviser.

Pantscast
Pantscast: Episode 57: Veloci-Adaptor Plug

Pantscast

Play Episode Listen Later Oct 19, 2021 35:16


In the episode, all Pantscast hosts are in the studio together! We are also joined in studio by Week 6 winner Katie. We discuss her word search skills and the possible use of a US to UK adaptor plug... The Pantscast is hosted by the critically acclaimed international team of Andy, Ben, and Brian. The podcast features hopeful award-winning segments of Pants News, GWIMPtionary, Stat That, and the Quick Pants Challenge. We include exclusive interviews in every episode with a GWIMP winner from the week.

Pantscast
Pantscast: Episode 57: Veloci-Adaptor Plug

Pantscast

Play Episode Listen Later Oct 19, 2021 35:16


The Hardware Asylum Podcast
The Evolution of the Graphics Adaptor from the Software Side

The Hardware Asylum Podcast

Play Episode Listen Later Jul 10, 2021 34:05


In this continuation episode the duo discusses the evolution of the graphics API that dictated the growth in the GPU market and defined how games were not only developed but consumed by enthusiasts. As a PC gamer we don't talk about the dark days of the Xbox 360 and the void called “Games for Windows” but, it is a defining moment in game development that changed PC hardware forever.

The Pilot Boys Podcast
EP. #087 To The Adaptor Goes The Spoils

The Pilot Boys Podcast

Play Episode Listen Later Jun 24, 2021 66:31


In Episode 87 The Boys tackle the Supreme Court's monumental decision to side with college athletes, Carl Nassib, the NBA playoffs, Partha's trip to NY as it reopens, and V's nightmare of a move. They then take a deep dive into adapting to the culture around you and finding your advantages.

The Hardware Asylum Podcast
The Evolution of the Graphics Adaptor

The Hardware Asylum Podcast

Play Episode Listen Later Jun 11, 2021 33:57


In this episode we talk about the evolution of the graphics adapter from the humble beginnings with CGA and ISA to the modern power house of 4k and PCI Express

Kate Dalley Radio
060321 Hour 3 Bill Gates Epstein Gates Doctor Connections DARPA ADAPTOR Program Very Scary

Kate Dalley Radio

Play Episode Listen Later Jun 3, 2021 59:58


060321 Hour 3 Bill Gates Epstein Gates Doctor Connections DARPA ADAPTOR Program Very Scary by Kate Dalley

The Expat Career Lifestyle
Episode 123: How To Adapt Abroad By Using The Universal Adaptor Metaphor. With Sara Coggiola

The Expat Career Lifestyle

Play Episode Listen Later May 19, 2021 33:18


Today I've invited Sara Coggiola, a Certified Professional CoActive coach, as well as a Cross-Cultural trainer. She also is co-chair of the Families In Global Transition Melbourne Affiliate in Australia. She is originally from Italy and has lived in France, Thailand, Luxembourg, and now Melbourne. With Sara, we speak about "How To Adapt Abroad By Using The Universal Adaptor Metaphor". You'll learn: what is the Universal Adaptor and how it can help you to adapt to a new country, SIMPLE Ways to discover what are your SKILLS and how to use them abroad when looking for a new career or starting a business, how Sara found her calling and reinvented her career, her Biggest challenge while adapting to a new country or culture, the importance of organizing your time as an expat or an expat mum, and much more. You'll find this episode helpful if you feel isolated or struggling to feel at home in your host country!   More about Sara: Sara Coggiola is a Certified Professional CoActive coach, as well as a Cross-Cultural trainer. She also is co-chair of the FIGT Melbourne Affiliate in Australia. She is originally from Italy and has lived in France, Thailand, Luxembourg, and now Melbourne. She offers Individual coaching, Cross-cultural training, and personal/professional Reinvention workshops.  Connect with Sara: Website: https://between-cultures.com/ Instagram Watch the video version of the interview here.   Did you like this interview? If yes please share it with your friends. Not sure what to do next in your career? Get your FREE 3-day e – career coaching programme and clarify your career goals in 3 days. Start your career change today! Clarify your career goals and elaborate your action plan to achieve them. Click here: https://dmcoaching.eu/

AI-ready Healthcare
Sandy Engelhardt: Heart bits

AI-ready Healthcare

Play Episode Listen Later May 11, 2021 50:10


Sandy Engelhardt is an assistant professor in the University hospital of Heidelberg, Germany. She leads the research group of AI in Cardiovascular Medicine. In this podcast, she talks about her research of using AI for complex Cardiac Surgery as well as the AdaptOR challenge (in association with the DGM4MICCAI workshop) we are co-organizing for MICCAI 2021.

Press Start To Join
PS2J 329 News - 2020 New Game Plus

Press Start To Join

Play Episode Listen Later Jan 8, 2021 44:44


united states fear netflix canada donald trump power china apple marketing technology action space state canadian zoom tech european fire government fighting mystery batman microsoft twitch adventure security fantasy conspiracies island launch epic wall press empire dark series sony childhood sharks whatsapp kitchen nerds senate small business playstation federal apocalypse xbox construction advertising windows geeks capitol combat galaxy privacy knight steam transparency playstation 5 lift steel permission expensive rpg samsung physics wire apology riot science fiction playstation 4 blizzard hilarious monopoly commander sims next gen puzzle shooters diablo law enforcement sonic the hedgehog breakdown ecosystem edmonton coop south park newspapers usb tactical passwords tomb raider diplomacy airpods playground arcade linux disinformation epic games xiii vet obstacle fleet gameboy cyberattacks cyberpunk 2077 king arthur ski browsers stealth antitrust bioshock end of life n64 xiaomi backdoor nebula bose excalibur pong bayonetta cd projekt red lara croft refund starcraft misfit digimon encryption macintosh techies suspend solarwinds internet archive first person data collection open world suppressing maneater tiananmen square adapter sentry overcooked little nightmares nintendo ds slope nintendo 64 game boy advance whimsical time loops emulators mockumentaries maw platformers video chat who's your daddy strawman roguelike 17th century snowmobiles sole survivor adobe flash greedfall visual novels jetbrains free games s21 gaming history general discussion king of fighters void bastards new game plus best podcast ever yeg ffx free internet blackthorne turn based punch club sargasso adaptor alberta podcast network command and conquer shadow hearts shadow of the tomb raider rise of the tomb raider bridge constructor brood war bustin out ps2j
Voice of the Arts
Alan Stanford - PICT

Voice of the Arts

Play Episode Listen Later Dec 21, 2020


Alan Stanford, Adaptor and Director of Charles Dickens "A Christmas Carol," discusses the 2020 PICT radio play production, the cast and special features, sound design and music, production process at WQED, the meaning of the play and its relevance to today, the 150th anniversary of Dickens death, whether his visit to Western Penitentiary in Pittsburgh inspired the chains of Marley's ghost in the play, whether Dickens is the greatest English author of all and theater superstitions including the ghost light left as a single bulb onstage when everyone goes home.

PaperPlayer biorxiv biophysics
Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

PaperPlayer biorxiv biophysics

Play Episode Listen Later Nov 3, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.03.364851v1?rss=1 Authors: Lizarrondo, J., Klebl, D. P., Niebling, S., Abella, M., Schroer, M. A., Mertens, H. D. T., Veith, K., Svergun, D. I., Skruzny, M., Sobott, F., Muench, S., Garcia-Alai, M. M. Abstract: During clathrin-mediated endocytosis, a complex and dynamic network of protein-membrane interactions cooperate to achieve membrane invagination. Throughout this process, middle coat adaptors, Sla2 and Ent1, must remain attached to the plasma membrane to transmit force from the actin cytoskeleton required for successful membrane invagination. Here, we present a cryoEM structure of a 16-mer complex of membrane binding domains from Sla2 and Ent1 that anchors to the plasma membrane. Detailed mutagenesis in vitro and in vivo of the tetramer interfaces delineate the key interactions for complex formation and deficient cell growth phenotypes demonstrate the biological relevance of these interactions. Finally, time-resolved experiments in solution suggest that adaptors have evolved to achieve a fast subsecond timescale assembly in the presence of PIP2. Together, these findings provide a molecular understanding of an essential piece for the molecular puzzle of clathrin-coated sites. Copy rights belong to original authors. Visit the link for more info

Press Start To Join
PS2J 324 News - Facebook Game-Vertisement

Press Start To Join

Play Episode Listen Later Oct 30, 2020 62:59


united states amazon money game canada new york city power google apple internet technology sports action canadian project tech gold government sales vice president elon musk search microsoft positive network twitch horror adventure judge video games gaming court press sony journalists profit elite threats reddit netherlands streaming nerds nintendo switch survival app mobile senate platform playstation ios next generation xbox advertising windows stream geeks strap waste fifa ghostbusters playstation 5 infrastructure upgrade port spacex lock gambling developers timeline beta publishers simpsons creative directors samsung delay fees psychological legion playstation 4 ea mouse batteries broken bethesda free speech app store next gen shooters bullshit terrorists among us file edmonton brick ubisoft gta ruling bill murray satellites cable signature real time usb patch first amendment default xbox one arcade improvements subscription console epic games starlink moderation packaging remastered gameplay liability stadia headphones oculus controller playstation 3 grand theft auto cyberpunk 2077 game pass wii occupation valhalla assassin's creed third party keyboard browsers stealth graphics streamer moderate antitrust dan aykroyd ps2 blair witch anker charger watch dogs cd projekt red no man's sky techies loot boxes super mario odyssey harold ramis xbox series fibre fair use gizmodo cloud gaming ernie hudson antenna crossplay farmville department of justice optic asynchronous section 230 watermark dsl touchscreens vice city fanart cross platform ultimate edition marvel super heroes alex hutchinson hello games free games savage planet gaming history fallout 3 general discussion missing child needful things low earth orbit best podcast ever yeg parapsychologists 30% jacksepticeye turtles all the way down adaptor alberta podcast network journey to jason rubin ps2j
PaperPlayer biorxiv biochemistry
The adaptor protein NumbL is involved in the control of glucolipotoxicity-induced pancreatic beta cell apoptosis

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Aug 16, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.16.253286v1?rss=1 Authors: Basavarajappa, H. D., Irimia, J. M., Fueger, P. T. Abstract: Avoiding loss of functional beta cell mass is critical for preventing or treating diabetes. Currently, the molecular mechanisms underlying beta cell death are partially understood, and there is a need to identify new targets for developing novel therapeutics to treat diabetes. Previously, our group established that Mig6, an inhibitor of EGF signaling, mediates beta cell death under diabetogenic conditions. The objective of this study was to clarify the mechanisms linking diabetogenic stimuli to beta cell death by investigating Mig6-interacting proteins. Using co-immunoprecipitation and mass spectrometry, we evaluated the binding partners of Mig6 under both normal glucose (NG) and glucolipotoxic (GLT) conditions in beta cells. We identified that Mig6 interacts dynamically with NumbL; whereas Mig6 associates with NumbL under NG, this interaction is disrupted under GLT conditions. Further, we demonstrate that siRNA-mediated suppression of NumbL expression in beta cells prevented apoptosis under GLT conditions by blocking activation of NF-B signaling. Using co-immunoprecipitation experiments we observed that NumbLs interactions with TRAF6, a key component of NFB signaling, are increased under GLT conditions. The interactions among Mig6, NumbL, and TRAF6 are dynamic and context-dependent. We propose a model wherein these interactions activate pro-apoptotic NF-B signaling while blocking pro-survival EGF signaling under diabetogenic conditions, leading to beta cell apoptosis. These findings indicate that NumbL should be further investigated as a candidate anti-diabetic therapeutic target. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv biochemistry
Crystal structure and molecular dynamics of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Jul 24, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.24.219980v1?rss=1 Authors: Kulik, A. A., Maruszczak, K. K., Thomas, D. C., Nabi, N. L. A., Carr, M., Bingham, R. J., Cooper, C. D. O. Abstract: Polymerase {delta}-interacting protein 2 (POLDIP2, PDIP38) is a multifaceted, moonlighting protein, involved in binding protein partners from many different cellular processes, including mitochondrial metabolism, DNA replication and repair, and reactive oxygen species generation. POLDIP2 is found in multiple cellular compartments, potentially shuttled depending on its role. How POLDIP2 binds to and coordinates many different proteins is currently unknown. Towards this goal, we present the crystal structure of the mitochondrial fragment of POLDIP2 to 2.8 [A]. POLDIP2 exhibited a compact two-domain {beta}-strand-rich globular structure, confirmed by circular dichroism and small angle X-ray scattering approaches. POLDIP2 comprised canonical DUF525 (ApaG) and YccV-like domains, but with the conserved domain linker packed tightly, resulting in an extended YccV module. A central channel through POLDIP2 was observed which we hypothesise could influence structural changes potentially mediated by redox conditions, following observation of a modified cysteine residue in the channel. Unstructured regions were rebuilt by ab initio modelling to generate a model of full length POLDIP2. Molecular dynamics simulations revealed a highly dynamic N-terminal region tethered to the YccV-domain by an extended linker, potentially facilitating interactions with distal binding partners. Finally we build models of POLDIP2 interacting in complex with two of its partners in genome stability, PrimPol and PCNA. These indicate that dynamic flexibility of the POLDIP2 N-terminal and loop regions are critical to mediate protein-protein interactions. Copy rights belong to original authors. Visit the link for more info

Oncotarget
Oncotarget: Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2)

Oncotarget

Play Episode Listen Later Jul 22, 2020 3:33


The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling. In the present study, the authors examined the biological effects of liposomal antisense oligodeoxynucleotide that blocks Grb2 expression in gynecologic cancer models. Murine orthotopic models of ovarian and uterine cancer were used to study the biological effects of L-Grb2 on tumor growth. In vitro experiments were carried out to elucidate the mechanisms and potential predictors of tumor response to L-Grb2. Treatment with L-Grb2 decreased tumor growth and metastasis in orthotopic models of ovarian cancer by reducing angiogenesis and increasing apoptosis at a dose of 15 mg/kg with no effect on mouse body weight. Reverse-phase protein array analysis identified significant dysregulation of metabolites in ovarian cancer cells after Grb2 downregulation. L-Grb2 has therapeutic efficacy in preclinical models of ovarian and uterine cancer. Dr. Anil K. Sood and Dr. Cristian Rodriguez-Aguayo from The University of Texas MD Anderson Cancer Center said, "Adaptor proteins are essential for signal propagation after receptor tyrosine kinase (RTK) activation." Druggable targets have often been proteins with enzymatically active sites to which small molecules could bind. However, the ability to target previously undruggable targets is evolving. Small-molecule inhibitors rely on intracellular targets or antibodies to inhibit the activity of growth factors, cell surface receptors, and cytokines. The development of nucleic acid interference-based therapeutics has allowed for regulation of gene expression to inhibit elusive targets. Nucleic acid-based therapeutics involves a process in which RNA molecules or antisense oligonucleotides inhibit gene expression or translation by neutralizing targeted mRNA molecules. After crossing the cell membrane, ASOs target mRNA directly through complementary base pair interactions, in the nucleus or cytosol, thus blocking and neutralizing targeted mRNAs. The Sood/Rodriguez-Aguayo Research Team concluded in their Oncotarget Research Paper, "we report that L-Grb2 has promising antitumor activity in preclinical models of ovarian and uterine carcinoma. Whereas the evidence of L-Grb2's activity against hematological malignancies is promising, whether it is active in clinical trials against solid tumors has yet to be tested. Therapies targeting the ErbB2 receptor have had limited success in ovarian cancer, but L-Grb2 may be a better target given its status as an important converging point for cancer cell signaling pathways." Sign up for free Altmetric alerts about this article DOI - https://doi.org/10.18632/oncotarget.27667 Full text - https://www.oncotarget.com/article/27667/text/ Correspondence to - Anil K. Sood - asood@mdanderson.org and Cristian Rodriguez-Aguayo - CRodriguez2@mdanderson.org Keywords - ovarian cancer, nucleic-acid based therapeutics, therapeutic approaches, uterine cancer About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

The Second Phase Podcast - Personal Branding & Brand Marketing and Life Strategies for Success for Female Entrepreneurs
Make Money Faster! VIDEO Is the Key to Having a Lucrative Business and Making More Impact!

The Second Phase Podcast - Personal Branding & Brand Marketing and Life Strategies for Success for Female Entrepreneurs

Play Episode Listen Later Jul 16, 2020 45:54


Patricia is an Emmy Award winning filmmaker and video creation expert.   She presently has three areas of focus within her entrepreneurial journey: Custom client videos Show Runner for “Life on the Line” television show Coach entrepreneurs on video creation First Phase Patricia wanted to be a news report like Lois Lane, but after doing competitive internships she was told that she looked too young, her hair was too long, and her voice was too high.  As a result, she took a job in PR for a non-profit.   Her role quickly changed to creating video instead of writing and photography. She received a crash course on video creation so that she could embark on a project.   From there she learned how to create and edit videos.  She traveled the world and did assignments creating documentary films.  Patricia observed the increase in revenue that flowed as the documentaries were released for the organizations she worked for. The non-profit she worked for was Loma Linda University Health in Southern California. Throughout her career she has earned 7 Emmy Awards. The Second Phase Patricia is living her second phase by teaching others how to create lucrative videos.   She shared so many valuable tips on how to create videos that will not only increase your online presence, but also generate revenue. Keys to Creating Great Videos Using the MAP Method (Messaging, Artistry, and Promotion) Messaging Set a goal Are you trying to grow your email list? Do you want people to schedule a discovery call? Create a how-to video? Think about the emotions you want your viewers to feel. Artistry Filming Lighting Ring light Indirect Sunlight from window  Audio  Microphone BOYA BYM1 for $20 on Amazon Stabilization Camera is stable, not shaking Tri-pod and phone adapter Amazon Basics 60 inch light weigh tri-pod $22 Adaptor for phone – Vastar Universal adaptor $9  Composition Want your eyes on the 2/3 line of the frame – not too low in the frame Fill the frame with negative space around but not dominating  Motion Get your establishing shot and show a wide view of where you are Create a medium shot Take close up shots Have diversity in the shots Put phone on slow-motion mode and tuck your elbows into your ribs to steady the phone and slide it horizontally or vertically This technique is great for a website banner Editing Music – evokes emotions  Promotion Optimize using key words Listen to Episode 37 of the podcast for ways to label the videos on your website, same as for pictures.   Length of Videos - Best Practices Have a hook at the very beginning Want to capture attention within the 1st 5 to 8 seconds Start with a smile and greet the audience Use a fact or statistic Share a transformation and tease your audience – irony Open with how you can make the audience's life better or easier YouTube loves videos that are 15 to 20 minutes Social media platforms want you to keep viewers on their platform The longer you keep them on your video the more likely they are to push out your content Have a Call to Action (CTA) at the end of each video Video Editing Tools iPhone iMovie Videorama ($) Android Kinemaster Mac Computers iMovie Final Cut Pro ($) PC's Filmora ($) Evoking Emotions with Video B-Roll - Video footage of you doing something while you are talking over it. It's the magic of editing.   You aren't live, you are talking, and the video is playing without your face being present the entire video. This is used for creating emotion. Music is another way to evoke emotion for the viewers. The Power of Video for Branding Viewer feels emotionally connected with you. Aberdeen Research reported that businesses that use video grow revenue 49% faster HubSpot found that 64% of customers say that seeing a video makes them more likely to buy Forbes said that the average user spends 88% more time on a website that has video – when more time is spent on a website, search engines are alerted, and they will drive more traffic to the website Evergreen video is like your twin selling for your all the time Multi-Vision Digital recently reported that the average life span of video is 4 years The average life span of a Facebook post is 3 hours and 7 minutes Learn more about and connect with Patricia Patricia Kelikani is an Emmy Award winner who has helped companies double and even triple their revenue with video.  She has 15 years of experience traveling the world as a documentary filmmaker, creating story-driven promo videos to help companies make more money, and producing a national television series. Known for her fun and simple teaching techniques, she's now helping entrepreneurs create lucrative videos for high impact, more money and reminding clients that not having a CTA after a video is like meeting the man of your dreams and not giving him your phone number! Website – https://lucrativevideos.com/ Free On-line course – https://lucrativevideos.com/training YouTube – https://www.youtube.com/patriciakelikani Instagram – www.instagram.com/patriciakelikani/         Learn more about your host, Robyn Graham, click HERE. To learn about The Brand Marketing Insider by Robyn Graham, click HERE. Book a Brand Marketing Strategy Session HERE. Ask Me Anything HERE. Join the Brand Marketing Insider Private Facebook Group HERE. Connect with me, Robyn Graham: Website | Instagram | LinkedIN | Facebook | Twitter | YouTube | Pinterest  

The Chaincode Podcast
Nadav Kohen and Payment Points - Episode 7

The Chaincode Podcast

Play Episode Listen Later Mar 30, 2020 49:44


In Episode 7, we chat with Nadav Kohen of Suredbits and discuss payment points as an alternative to HTLCs on the Lightning Network. In this conversation we cover: Payment points (1:55) - Blog post part 1 - HTLCs (2:00) Timelocks (4:16) HTLC drawbacks (5:38) - Payment decorrelation - Wormhole attack presented in Anonymous Multi-Hop Locks for Blockchain Scalability and Interoperability (6:35) Point time lock contracts (PTLCs) (9:50) - Adaptor signatures on Schnorr Proof of payment (13:25) Invoiceless transactions (15:05) Hashes, pre-images, and HTLC mechanics (16:35) Onion analogy (18:55) PTLC mechanics (19:30) Why don't we use PTLCs today? (22:15) Lightning in Scriptless Scripts posting by Andrew Poelstra March 2017 Improving proof of payment (26:10) Stuckless payments (30:46) Spam on Lightning (35:46) Selling Signatures and Schnorr signatures off the main chain (36:55) Contingent payments (39:20) Escrow contracts (41:28) Atomic multiparty setup and payment renegotiation (46:02) ETA of payment points (48:02) Thanks as always to Matthew Zipkin for the sound engineering.

Jana Wieduwilt
Jana Wieduwilt #87 - Erfinder oder lieber Nummer Sicher? Wie du Dein Marketing drauf ausrichten kannst!

Jana Wieduwilt

Play Episode Listen Later Mar 4, 2020 11:09


#Innovator, oder Adaptor? Wer bist du? Hier erzähle ich dir am Beispiel von Neuseeland, wie du dein #Marketing als Adaptor oder Innovator ausrichten kannst. Beim #businesspilgern!  

Growing With Harjot Podcast
027: Survival of the Adaptor

Growing With Harjot Podcast

Play Episode Listen Later Feb 2, 2020 50:02


We live in a world where most people struggle to even survive life and it's harsh reality and circumstances that everyone is put through. If you want to not only learn how to survive in life but also THRIVE and enjoy every moment of it while you are doing the process of 'living' your best life then this episode is for you, a MUST listen to open your mindset to a way of l00king (the 00 are on purpose, imagine them as your eyes looking at the world) that will take you to places you never knew existed!

Motivion In Hindi. Hindi Motivion. Story In Hindi. Insiprational Story. Motivational Story
एक सेकेंड, एक मिलियन डॉलर । Motivational and insiprational story. Be early adaptor

Motivion In Hindi. Hindi Motivion. Story In Hindi. Insiprational Story. Motivational Story

Play Episode Listen Later Jan 27, 2020 2:38


एक सेकेंड, एक मिलियन डॉलर । Motivational and insiprational story. Be early adaptor. Aadhish Raman Motivation --- Send in a voice message: https://anchor.fm/aadhish-ramanMotivation/message Support this podcast: https://anchor.fm/aadhish-ramanMotivation/support

Riot Point Radio
Riot Point Radio Episode 13: The life and times of the creative adaptor

Riot Point Radio

Play Episode Listen Later Nov 18, 2019


When you solve problems, do you prefer to think out of the box? In fact, do you take a sledge hammer to the box and pulp it. If so, then you’re an innovative problem solver (and a muscular one too it would appear) according the Kirton Adaptor Innovator theory or KAI. Or do prefer to be creative by looking at what's worked in the past, and extending that success by continuous improvement. Are you the go-to person for building impressive thick-walled, rebar-reinforced boxes. If it ain't broken, improve it is your motto. Then, according the Kirton Adaptor Innovator theory, you're an adaptive problem solver. To be successful we need both styles but, as you'd expect, those of us making better beautiful boxes don't always appreciate a sledge hammer through the front door. So how should innovators and adaptors work with each other for greatest mutual benefit? Well you're about to one half of the answer. In part 1 we heard from an innovators perspective. In part 2 Sandi gives us the adaptors perspective. We join a conversation already in progress Sandi, thank you for participating. If you're interested in the innovators perspective, you'll find a link in the show notes. If you're interested in knowing whether you're an innovator or a creative adaptor, have a look at the website theriotpoint.com Or, you can send me an email, iwanjenkins@theriotpoint.com

The World Crypto Network Podcast
Use Cases of Schnorr, MuSig, Adaptor and Blind Signatures ~ bitcoin-dev Mailinglist (2)

The World Crypto Network Podcast

Play Episode Listen Later May 12, 2019 24:02


Here are two BIP drafts that specify a proposal for a Taproot softfork. A number of ideas are included: * Taproot to make all outputs and cooperative spends indistinguishable from eachother. * Merkle branches to hide the unexecuted branches in scripts. * Schnorr signatures enable wallet software to use key aggregation/thresholds within one input. * Improvements to the signature hashing algorithm (including signing all input amounts). * Replacing OP_CHECKMULTISIG(VERIFY) with OP_CHECKSIGADD, to support batch validation. * Tagged hashing for domain separation (avoiding issues like CVE-2012-2459 in Merkle trees). * Extensibility through leaf versions, OP_SUCCESS opcodes, and upgradable pubkey types. The BIP drafts can be found here: * https://github.com/sipa/bips/blob/bip... specifies the transaction input spending rules. * https://github.com/sipa/bips/blob/bip... specifies the changes to Script inside such spends. * https://github.com/sipa/bips/blob/bip... is the Schnorr signature proposal that was discussed earlier on this list (See https://lists.linuxfoundation.org/pip...) https://lists.linuxfoundation.org/pip... https://twitter.com/pwuille

The Red Menace
16 - Herbs and Spices Adaptor

The Red Menace

Play Episode Listen Later Nov 4, 2018 48:29


This week we talk about the ghost mile-high club, the KFC of the future, Yelp vandalism, a just very bad headline, adorable wallaby rescues, debut a new spooky segment, and whether or not it's okay to murder someone over spoilers. There are lots of cool stories and lots of barely-connected tangents into dumb jokes. Enjoy! Also, fair warning, there are a fair few audio glitches in the recording this week. We discovered it too late to fix it and have edited around them as much as possible. We apologise, and it won't happen again.

Biologize
Biologize Episode 7 Poison Adaptor Competitive Advantage

Biologize

Play Episode Listen Later May 20, 2018 19:13


Achieving sustainable competitive advantage is a challenge for all organisations. Trying to achieve it in an environment that is toxic is harder still. What if there was a way to use existing resources to not only dominate an industry niche but to also create a toxic environment for your competition? What if you could turn on its head the resource-draining risk mitigation plan and use it to create a competitive advantage. In this episode, I explore the Poison Adaptor model based on the counterintuitive processes some beetles follow to achieve competitive advantage and survival. In this episode, I share an example from financial services that demonstrates how the Poison Adaptor mode has been applied to achieve success. The Poison Adaptor model for Competitive Advantage is one of the Business Biomimetics approach. For further information check out www.biologize.co.uk  

Consumer Tech Update
4 things you must do to get your smartphone ready for summer travel

Consumer Tech Update

Play Episode Listen Later May 9, 2018 1:08


With summer around the corner, you’re likely planning weekend trips and family vacations. Whether you’re going to another state or another country, don’t miss these four most important things for your smartphone to have on hand when traveling.

Consumer Tech Update
4 things you must do to get your smartphone ready for summer travel

Consumer Tech Update

Play Episode Listen Later May 9, 2018 1:08


With summer around the corner, you’re likely planning weekend trips and family vacations. Whether you’re going to another state or another country, don’t miss these four most important things for your smartphone to have on hand when traveling.

Act II @ A.R.T.
WARHOLCAPOTE Act II Discussion with Rob Roth

Act II @ A.R.T.

Play Episode Listen Later Oct 6, 2017 27:04


The Adaptor of WARHOLCAPOTE, Rob Roth received a Tony nomination for his Broadway directing debut, Rob Roth (Photo: Gretjen Helene Photography)Disney’s Beauty and The Beast, which went on to become the eighth-longest-running show in Broadway history. "Beauty" has been seen by more than 40 million people all over the world, winning many awards, including the Olivier Award for Best Musical in London. Rob went on to direct the inaugural production of Elton John and Tim Rice’s AIDA, and the Broadway musical Lestat, based on the Anne Rice Vampire Chronicles, with score by Elton John and Bernie Taupin. In addition to his work in theater, Rob is a frequent director of rock concerts, working with legendary artists KISS, Alice Cooper, Cyndi Lauper, The Dresden Dolls, and guitar great Steve Miller, among others. Rob has one of the world’s largest collections of rock and roll graphics, which are featured in the book The Art of Classic Rock. Rob is married to Dr. Patrick Meade and lives in New York City with their two Labs, Dash and Tag.

Perthian Chronicles
Chapter Eighteen: "Until The Day I Die"

Perthian Chronicles

Play Episode Listen Later Sep 16, 2017 70:00


Ryan is met with awarding winning Actor, Director, Adaptor and emerging Teacher, Humphrey Bower. The two chatted about: The ethics of living and acting, fruity 'black face' actors, the unknown knows, old dogs learning new tricks, the historical struggle for resources for the theatre sector, Danielle Micich, Shakespeare our lord and master and faith in the adaptation business. Sit back, relax and enjoy a chapter with bonus Bird Song.

Side Hustle School
#217 - Getting Charged Up: Man Creates One Adaptor to Rule Them All

Side Hustle School

Play Episode Listen Later Aug 5, 2017 8:21


Tired of a road warrior’s tangle of cables and plugs, a Hong-Kong-based entrepreneur makes chargers and adapters truly current.  Side Hustle School features a new story EVERY DAY of someone who started a hustle without quitting their job. You’ll learn how they got the idea, how they overcame challenges along the way, and what the results are. You need a hustle! Share: #SideHustleSchoolShow notes: SideHustleSchool.comTwitter: @chrisguillebeauInstagram: @193countries Learn more about your ad choices. Visit megaphone.fm/adchoices

48 Days to the Work You Love Internet Radio Show
Guess what – I just bought the farm!

48 Days to the Work You Love Internet Radio Show

Play Episode Listen Later Jul 7, 2017 39:14


Guess what – I just bought the farm! History tells us that when a military jet crashes on a farm the farmer typically gets the government to pay off the mortgage on that farm.  And thus the saying, “He bought the farm” refers to someone dying.  But then there's the positive side of just deciding to have a small farm.  I've got an opportunity where you might just be able to do that – for $300. Do you think the benefits of homeschooling outweigh the costs?  And How can we nurture the entrepreneurial spirit of our children? How do you feel about creating a mastermind group within one industry working in the same area? Should I look at established business opportunities or start something totally new? And I've got good news – See how this kid helped his 75 yr-old Mom complete her bucket list And a whole lot more questions if we get to them. “I have no special talents.  I am only passionately curious.”  Albert Einstein – Tweet This Cliff Feightner‘s Poem This Week When you feel at the end of your ropeIn the workplace, how do you copeAre you prepared to adaptOr just feel that you're trappedIn a job without any hope  Show Notes: Episode – 07-07-17 Title: N/A Subtitle: N/A Summary: This holiday week, Dan shares wonderful success stories from members of 48 Days as well as an opportunity where YOU can win a 13 acre farm! He also addresses questions from listeners including whether one should start a new business idea or compete with others in established markets. Dan also discusses the topic of homeschooling as he and his wife, Joanne, made the decision to homeschool their own children. Tune in to find out how family time fosters an entrepreneurial spirit in our children and why it's important to start a business that blends in a person's passion, talent, and money.   Time Stamped Show Notes: 01:02 – Preview of Today's Show on “Guess what – I just bought the farm!” History tells us that when a military jet crashes on a farm the farmer typically gets the government to pay off the mortgage on that farm. And thus the saying, “He bought the farm” refers to someone dying. But then there's the positive side of just deciding to have a small farm. I've got an opportunity where you might just be able to do that – for $300. Do you think the benefits of homeschooling outweigh the costs? And how can we nurture the entrepreneurial spirit of our children? How do you feel about creating a mastermind group within one industry working in the same area? Should I look at established business opportunities or start something totally new? And I've got good news – See how this kid helped his 75 yr-old Mom complete her bucket list And a whole lot more questions if we get to them. “I have no special talents. I am only passionately curious.” Albert Einstein 03:54 – A poem by Cliff FeightnerWhen you feel at the end of your rope In the workplace, how do you cope Are you prepared to adapt Or just feel that you're trapped In a job without any hope 04:23 – Success story from West, It all began in your (Dan's) Eagle's Club Coaching that I took way back in 2005. My side hustle business is nearly 100% residual income and pays for our new 4K+ sq ft home 06:21 – Dan explains the power of SWISS dollars 07:17 – When you're working 40 hours per week, you calculate your pay based on 40 hours 07:25 – When you open a store online, you're open 168 hours per week 07:53 – Would $15/hour make you suffer having been used to earning $70K/year? NO – $15/hour in a year is $130K 08:28 – This is the power of SWISS dollars 08:59 – See how this kid helped his 75 yr-old Mom complete her bucket list 09:09 – Sian Regis was well aware of how he treated his mother, Rebecca, when he was younger 09:24 – Rebecca was a single-mom who worked as a hotel maid for years 09:32 – Now, Sian is making it up to her 10:03 – The young entrepreneur helped his mom to complete her bucket list 10:46 – Paramedics stopped to do the right thing after seeing a 98-year old mowing the lawn in the heat 11:08 – They pulled the ambulance over at the senior's house 11:20 – They went ahead and mowed her lawn 11:35 – Police officers bought an air conditioner for a 95-year old veteran 11:49 – The officers received a 911 call from the senior distressed over his air conditioner 12:03 – The officers visited and were appalled at the veteran's condition 12:17 – They went to home depot to look for an air conditioner 12:25 – The store employees were touched and threw in $150 of their own money 12:35 – The police officers put $150 as well to split the cost 12:43 – They went back to the veteran's house and installed the new air conditioner 13:05 – UPS has a new ad out with the line, “As a kid did you ever knock on other people's doors, then run away before they could answer? Guess what? We're hiring!” 13:56 – Dan shares about Matt “buying the farm” 14:16 – Matte interviewed Norma, who was giving away her 13 acre farm 14:33 – Norma is moving to a retirement home 14:49 – She's taking applications with essays from couples who want to be farmers 15:02 – Win a North Carolina farm contest – https://www.essaybluebirdhillfarm.com 15:14 – There's a fee of $300 per application 15:29 – She owes $189K on her farm that she'll pay off once she gives it away 16:17 – Verify that you can run a farm like this 17:30 – Dan wants somebody from the 48 Days community to win! 18:01 – Dan plays Watching the Wheels 20:11 – Anthony asks, Do you think the benefits of homeschooling outweigh the costs? And how can we nurture the entrepreneurial spirit of our children? 20:47 – Dan had their kids in regular school until it became clear that Jared wouldn't make it in the system 20:15 – Dan and Joanne pulled out Jared from school and then, they pulled out Ashley 21:37 – They used Zig Ziglar's recordings 22:11 – Just living life together as a family nurtures the entrepreneurial spirit 23:08 – You don't need to be very sophisticated or structured when you live with your kids 24:07 – The $100 Startup is a resource Dan recommends 24:15 – Dan's 48 Low-Cost Business Ideas 25:45 – Rusty says, How do you feel about creating a mastermind group within one industry working in the same area? 26:09 – “Masterminds are one of those terms that is being used and abused dramatically” 26:27 – Your idea makes sense 26:38 – Collaborate instead of competing 27:11 – Dan was a member of IMCAP for years 28:04 – Send your questions and success stories to AskDan or askdan@48days.com 28:46 – Sean says, Should I look at established business opportunities or start something totally new? 29:29 – You can compete in established business opportunities 29:46 – Domino's Pizza's 30-minute delivery is an example of this 30:23 – Dan shares about Shane who picks up dry cleaning 31:39 – Be careful about just identifying where you know there's a need 32:04 – “You have to include your passion” 32:40 – Dan uses Jamie's question as an example 34:31 – Make sure you have the blend of passion, talent, and money in the business you'll build 35:05 – Kris, who lives in Florida, sent a message to Dan for a possible meet up 36:54 – Dan hopes that you approach unexpected opportunities the same way he does 37:43 – Dan is behind schedule with the plans he's made for himself 38:12 – Dan closes today's podcast 3 Key Points: No matter how dark our days may feel, there's always a brighter side. Today is not about competing anymore, it's about collaboration. Treat your problems as opportunities for growth. Resources Mentioned: To ask Dan a question for the podcast – AskDan The new 48 Days Eagles site – This is the best place for moving your career forward Make money and serve as a 48 Days Seminar Presenter Win a North Carolina farm contest – https://www.essaybluebirdhillfarm.com How I make money coaching – Dan's blog CES Conference with Jim Cockrum – for all online biz (I'll be there!) Credits: Show Notes provided by Mallard Creatives   The post Guess what – I just bought the farm! appeared first on Official Site Dan Miller.

Leverage
Pulsed Electromagnetic Stimulation To Sync Mind and Body, A Universal Travel Adaptor, Get Money You’re Owed - Episode #43

Leverage

Play Episode Listen Later Jun 16, 2017 10:45


Pulsed Electromagnetic Stimulation (PEMS) has nearly 50 years of medical/neurological applications and scientifically-proven health benefits and on today’s episode of OAO, we discuss a new device - the Elf Emmit that has come on the scene to help you align your body with your mind. It sounds a bit odd and requires that you wear a funky headband with a cable running to your smartphone, but if it works, it’s really cool. Pulsed Electromagnetic Stimulation devices may be something you should put on your radar, and you can check out one such device on this episode. A travel adapter you won’t mind using.  Most travel adapters are bulky and don’t always work like you expect. But those days are gone with the advent of Micro, a mini-travel adaptor that’s got Ari very excited. On this episode of OAO, the guys talk about this new device and why it’s an extreme upgrade from the traditional travel adapters that have been around for years. And this one has a surge protector fuse to keep your devices safe. If you travel internationally you’ll want to see this. Get the money your health insurance company owes you.  How many times have you paid a medical expense out of pocket only to forget that you need to file the claim with your medical insurance company? There’s a new service called Get Better that tracks down the claims you’re owed by your medical insurance provider and takes steps on your behalf to get that money for you, saving you the time of doing it yourself. This episode the guys talk about Get Better and a handful of other apps and services. Now you can have medical issues addressed in your own home. FRND is a new service that contracts with healthcare providers, insurance companies, senior living facilities, and more to perform certain healthcare services for patients in the comfort of their own homes. It’s a great way to cut costs, keep people out of waiting rooms and hospital ERs, and make healthcare more personal. And, healthcare providers like RNs can find flexible work that doesn't keep them stuck in an office all day. Nick and Ari discuss FRND and a whole lot more on this episode, so be sure you listen. One co-working subscription to rule them all.   The concept of co-working spaces is already a great example of the sharing economy in action. It was only a matter of time until it became even more shared. Desk Pass is a monthly coworking subscription that has agreements with co-working locations in Chicago, New York, Los Angeles, and Denver. Sign up and get affordable, flexible access to over 100 different co-working spaces in those cities. Sounds like a winner. Find out more on this episode. Featured Resources Mentioned On This Episode  [0:03] Dashboard updates and problem solving details. [4:53] Bone broth for health (sponsor message) [5:44] The Micro Travel Adaptor [6:19] Elf Emmit device for electrical stimulation [7:10] Purity Coffee and Laird’s Coffee [7:30] http://GetBetter.co  - get back money you are owed [7:55] FRND - home healthcare scheduling app [9:18] Desk Pass - app to access co-working spaces Other Resources Mentioned  Text “Leverage” to “444999” to subscribe to the mailing list and get the first chapter of our new book. Kettle and Fire (sponsor) - use “Get Leverage 15” as your coupon code Zencastr Inside Tracker www.GetLeverage.com - sign up for the Fall release of Dashboard.   Find out more about what we’re doing at Leverage at www.getleverage.com and www.leveragepodcasts.com

LA Theatre Bites - Podcast
Interview with Annie Loui Director and Adaptor of Longitude @ UCI Irvine – Podcast

LA Theatre Bites - Podcast

Play Episode Listen Later Mar 17, 2017 5:03


A devised physical theatre production exploring invention, engineering & obsession in the 18th century. LONGITUDE is a devised theater performance about 18th century inventor/clockmaker John Harrison, and his entry into the most important race of the century; to discover a means of measuring longitude. March 16 – 18, 2017 Experimental Media Performance Lab (xMPL) Performances: Evenings: March 16, 17, 18 @ 8 p.m. 2017 Matinees: March 18 @ 2 p.m. FREE

The Blood-Jet Writing Hour, a Writing Podcast
Episode #123: John Jennings, illustrator and co-adaptor of Octavia Butler's KINDRED

The Blood-Jet Writing Hour, a Writing Podcast

Play Episode Listen Later Mar 3, 2017 42:08


Episode #123: John Jennings, illustrator and co-adaptor of Octavia Butler's KINDRED John Jennings is Professor, Media and Cultural Studies, University of California, Riverside. His work centers around intersectional narratives regarding identity politics and popular media. Jennings is co-editor of the Eisner Award-winning essay collection The Blacker the Ink: Constructions of Black Identity in Comics and Sequential Art and co-founder/organizer of The Schomburg Center's Black Comic Book Festival in Harlem. He is co-founder and organizer of the MLK NorCal's Black Comix Arts Festival in San Francisco and also SOL-CON: The Brown and Black Comix Expo at the Ohio State University. Jennings sits on the editorial advisory boards for The Black Scholar and the new Ohio State Press imprint New Suns: Race, Gender and Sexuality in the Speculative.

The Circle Of Insight
Top Brain and bottom Brain with Dr. Kosslyn

The Circle Of Insight

Play Episode Listen Later Jan 24, 2017 15:50


In this groundbreaking contribution to the literature of human personality, a celebrated psychologist and an award-winning author offer an exciting new way of thinking about our minds—and ourselves—based on a new way of looking at the brain. IN THIS GROUNDBREAKING contribution to the literature on human personality, a celebrated psychologist and an award-winning author offer a novel way to learn about how each of us thinks. For the past fifty years, popular culture has led us to believe in the left brain vs. right brain theory of personality types. It would be an illumi­nating theory if it did not have one major drawback: It is simply not supported by science. In contrast, the Top Brain, Bottom Brain theory is based on solid research that has stayed within the confines of labs all over the world—until now. With cowriter G. Wayne Miller, Stephen M. Kosslyn, PhD, a leader in the field of cognitive neuroscience, explains this exciting new theory for the first time. Kosslyn and Miller describe how the top and bottom parts of the brain work together, summarizing extensive research with ease and accessibility. In doing so, they introduce us to four modes of thought: Mover, Perceiver, Stimulator, and Adaptor. These ways of thinking and behaving shape your personality, and with the scientifically developed test provided in the book, you'll quickly be able to determine which mode best defines your dominant way of thinking. Once you've identified your dominant cognitive mode, you can reflect on the many possible practical applications from the way you conduct business to your relationships to your voyage of personal discovery.

Menswear Style Podcast
Michael Stone of Brutus, Andrew Tompsett of Merc, Paul Brown of Adaptor Clothing, Phil Bickley of Real Stars Are Rare & Stephen Hattersley of Carnaby Designs

Menswear Style Podcast

Play Episode Listen Later Oct 27, 2016 54:28


We look back to the 1960s and discuss the Mod subculture clothing industry with some its key players. We chat to some of the biggest names, founders and designers of the current Mod world. We speak to Phil Bickley at Real Stars Are Rare, Andrew Tompsett at Merc, Paul Brown at Adaptor Clothing, Stephen Hattersley at Carnaby Designs and Michael Stone at Brutus. Whilst we have your attention, be sure to sign up to our daily MenswearStyle newsletter here. We promise to only send you the good stuff.

Snap-on TV
Snap-on BJP1-29A Ball Joint Adaptor for Honda and Acura | Snap-on Tools

Snap-on TV

Play Episode Listen Later Sep 12, 2016 1:01


With more and more Honda and Acura vehicles on the road these days, service technicians will have ample opportunity to service these models in the next several years. To help its customers improve their share of the Honda and Acura repair market, Snap-on has developed a Ball Joint Press Honda Adapter Set (BJP1HONDA) to use with Snap-on’s Ball Joint Press Master Set (BJP1). 

Science Signaling Podcast
Science Signaling Podcast for 12 July 2016: Adaptor proteins limit signaling

Science Signaling Podcast

Play Episode Listen Later Jul 11, 2016 13:45


Steven Wiley describes a quantitative study that shows that adaptor proteins, not core signaling components, control the flow of information through the EGF pathway.

Snap-on TV
Snap-on Ball Joint Adaptor

Snap-on TV

Play Episode Listen Later Jan 15, 2016 1:17


Easy to use design makes quick work of ball joint repairs, improving technician efficiencyFeaturing fewer parts than competitive units, the Snap-on® BJP1-28A Ball Joint Adaptor is uniquely designed to enable greater technician productivity. The frame-straddling cutout allows increased work room during the removal and installation of lower and upper ball joints on Dodge® 4x4 Ram® 2500® and 4x4 Ram® 3500® (model years 2003 and up) and Ram® 1500® Mega Cab® (model years 2004-2010). Featuring a flip design that uses both sides of the adaptor, the BJP1-28A is easy to install. Used in conjunction with the Snap-on® BJP1 Ball Joint Press, the combination ensures adaptors are held in place for a secure fit.

Gritty Podcast
EPISODE 57: What Camera Does Aron Snyder Use?

Gritty Podcast

Play Episode Listen Later Dec 28, 2015 74:28


SUBSCRIBE: iTunes / RSS/Stitcher/Podbean Episode 57: Camera Gear with Aron Snyder In this podcast Aron covers what lenses he uses, the different cameras he’s tried and what he is currently using and why, his journey through photography and how you can improve your photos, chest straps and clips, what packs he uses, and the questions he gets about photography.  “Hey Aron - I want to get into photography. I want to take photos of animals from long distances and I have a $1000 budget…”  Featured in this podcast: Sony RX100 Oneof the best pocket backpack camera’s.   Olympus OD EM 1 Sony A7R Sony NEX5 Sony NEX6 Sony NEX7 Olympus ODEM Olympus ODEM1l Canon 6D 5D Mark3 Canon Nikon D8-10 Canon LINKS FoR CAMERA BASICS in the other podcast  Peak Design  Kifaru Zing The 22 Mag or the Zing F-Stop ICU Pod Sony A7R11 Arca Swiss Mount Gitzo Tripod Suri head ARca Swiss Mount   50 Millimeter 35MillimeterLenses 15 Millimeter Boylander 12 Ml Fisheye 35 ml.  90 ml. Macro Swarovski TLS APO Digi scoping Adaptor  

Ruminate Podcast
9 - Stupid Tiny Adaptor

Ruminate Podcast

Play Episode Listen Later Dec 14, 2015 57:28


John and Robb discuss Kickstarter, headphones, copycat apps and the new X-Men trailer. Follow Up Menu - The Frontier Chicago iPhone 6 Wallet Case, iPhone 6 Wally Wallet Case | Distil Union Minimalist Wallet Thoughts — scrubbs.me Kickstarter How long will 'Paint Drying' be? An unusual commission — Medium Robb Lewis —Kickstarter I wonder what it's like to be dyslexic by Sam Barclay —Kickstarter SEGA Mega Drive/Genesis: Collected Works by Darren Wall —Kickstarter App: The Human Story by Story & Pixel —Kickstarter CINCH :: A Rad Minimalist Wallet :: Slim, Simple, Secure by Portsmith Co. —Kickstarter Maintenance-Free Bicycles that Make Cycling Easy by Dave Weiner —Kickstarter The Pen Addict Podcast: Live at the 2015 Atlanta Pen Show by NockCo —Kickstarter Headphones Robb Lewis on Twitter: "Mark the day: If Apple remove the headphone port next year, I’m going Android." Sennheiser Momentum 1.0 Closed Circumaural Over-Ear: Amazon.co.uk: Electronics The Best Bluetooth On- or Over-Ear Headphones | The Wirecutter Audio-Technica ATH-M50X Studio Monitor Professional Headphones - Black: Amazon.co.uk: Musical Instruments Amazon.com: Sennheiser PX 200 II Closed Mini Headphones with Integrated Vol Control (Black): Electronics Amazon.com: JayBird BlueBuds X Sport Bluetooth Headphones - Midnight Black: Cell Phones & Accessories Beats Powerbeats2 Wireless In-Ear Headphones, Active Collection - Apple Amazon.com: Plantronics BackBeat Fit Bluetooth Headphones - Green: Cell Phones & Accessories Ep. 137: ‘Peak Rumor Season’, With Special Guest John Moltz — The Talk Show With John Gruber — Overcast Apple releases $99 iPhone 6s Smart Battery Case, Apple’s first official battery pack iPhone case | 9to5Mac Copycat Apps John Voorhees on Twitter: "One of these things is not like the others... Hint: it's legit. https://t.co/DZbx8Z5qk9" Copying a design is easy, but creating a great experience is hard. — Medium How App Store grifters clone an overnight success to make a quick buck | Ars Technica Robb Lewis on Twitter: "“Oh Flappy Bird? No no. This is Flappy Salmon. Completely different.” https://t.co/mqiF5mzHNr" Misc X-MEN: APOCALYPSE | Official Trailer [HD] | 20th Century FOX - YouTube Best News Bloopers 2015 on Devour.com Top Four #9: Christmas Music - Relay FM The high cost of podcasting. Robb records a show, his cat kills a pigeon: http://d.pr/i/1j1Uy Contact Us Email contact@ruminatepodcast.com Hashtag #askruminate

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 04/06
The adaptor protein Migfilin is dispensable for mouse development and homeostasis, but suppresses tetraploidy and acts as a tumor suppressor in skin

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 04/06

Play Episode Listen Later May 12, 2011


Thu, 12 May 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13854/ https://edoc.ub.uni-muenchen.de/13854/2/Moik_Daniel_V.pdf Moik, Daniel V.

Tech Talk from the Markertek News Channel
Hoodman EX Kit Pro LCD Viewfinder Adaptor Kit

Tech Talk from the Markertek News Channel

Play Episode Listen Later Dec 20, 2010


The Hoodman EX Kit Pro kit enables you to turn your EX LCD screen into a viewfinder for excellent outdoor performance. The Kit comes with 4 components... 1) HoodLoupe 3.0 is engineered to give you a true 1 to 1 LCD screen image with German glass optics allowing a plus or minus 3 diopter adjustment. 2) HoodRiser Attachment enables the HoodLoupe to fit great at the outer edge of your EX LCD screen bezel for full screen viewing. 3) Camcorder Strap securely mounts the HoodLoupe to your EX LCD screen. 4) HoodMAG 3.0 has a 3X magnification and upgrades the eyepiece of the HoodLoupe to seal out all ambient light.

Science Signaling Podcast
Science Signaling Podcast, 09 June 2009

Science Signaling Podcast

Play Episode Listen Later Jun 8, 2009 24:14


Adaptor subunits of phosphoinositide 3-kinase gamma specify distinct cellular responses.

science allergy signaling mast cell adaptor pip2 pi3 kinase degranulation
Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06
Comparative analysis of the functions of integrin adaptor molecules ILK and PINCH1 in the skin epithelium

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06

Play Episode Listen Later May 9, 2008


Fri, 9 May 2008 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/12502/ https://edoc.ub.uni-muenchen.de/12502/1/Lorenz-Baath_Katrin.pdf Lorenz-Baath, Katrin ddc:540, ddc:500, F