Podcasts about Pesto

Actor Kandi Burruss sits down to talk about starring in & Juliet on Broadway. Plus, social media makeup artist Erica Taylor shares tips to help women update their beauty routines. And, bestselling author Diane Morrisey also stops by to share her recipe for pesto turkey meatballs. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Anne ist Fachärztin für Innere Medizin und Rheumatologie, Bestsellerautorin und vielen als „Doc Fleck“ aus dem Fernsehen und ihren Büchern bekannt. Ich wollte von ihr wissen, wie wir gesund ins neue Jahr starten, was stille Entzündungen genau sind, warum sie so viele unserer heutigen Krankheiten antreiben und wie wir es schaffen, langfristig gesund zu leben. Wir sprechen über gutes und schlechtes Fett, über gesundes Frühstück und Abendessen – ich hatte Fragen zu Pasta, Pesto und Snacks. Es geht um Autophagie, Longevity, Spiritualität, Atem und die Frage, wie man Gesundheitswissen wirklich langfristig in den Alltag bekommt. WERBEPARTNER & RABATTE: https://linktr.ee/hotelmatze MEIN GAST: https://www.instagram.com/docfleck/ DINGE: Ran an das Fett – Anne Fleck: https://bit.ly/4jC4OsG ENERGY! in 5 Minuten – Anne Fleck: https://bit.ly/4jCug1i Film “Lorenzos Öl”: https://bit.ly/4bEnVAm Immaterielles Kulturerbe “Kneippen”: https://bit.ly/4jFkagd FAKTEN: Aktuelle Erkenntnisse zu den Auswirkungen von hochverarbeiteten Lebensmitteln auf den Körper: https://bit.ly/4sGcTkm Untersuchung von Algen- und Fischölen bzgl. Oxidation: https://bit.ly/49Gv68Q Studie zur langfristigen Auswirkung von Stress aufs Immunsystem: https://bit.ly/49BuYrc Studie zur Umsetzung von Forschungsergebnissen in die Praxis: https://bit.ly/49wIwnD Alexander Stößlein - Produktion Lena Rocholl - Redaktion Mit Vergnügen - Vermarktung und Distribution MEIN ZEUG: Mein Fragenset FAMILIE: https://beherzt.net/products/familie Mein Fragenset LIEBE: https://beherzt.net/liebe Mein erstes Fragenset: https://beherzt.net/matze Meine Spendenaktion: https://machmit.wellfair.ngo/hotel-matze-spendenaktion-2025 Mein Newsletter: https://matzehielscher.substack.com/ YouTube: https://bit.ly/2MXRILN TikTok: https://tiktok.com/@matzehielscher Instagram: https://instagram.com/matzehielscherHotel LinkedIn: https://linkedin.com/in/matzehielscher/ Mein Buch: https://bit.ly/39FtHQy

Stroke etanercept injection 18 months on: what lasted, what changed, and what Andrew learned after the PESTO trial Some stroke survivors are told a version of the same sentence in hospital: “After three months, what you have is what you'll have.” Andrew Stops didn't buy it, not because he was naïve, but because he needed a reason to keep showing up for rehab when nobody could give him a straight answer about what “recovery” would look like. Four years after his ischemic stroke, and 18 months after a stroke etanercept injection, Andrew is back to share what improved quickly, what continued to evolve, and how he made peace with research results that didn't match his lived experience. The question so many survivors are really asking When people reach out about perispinal etanercept (often discussed as “etanercept after stroke”), they're rarely asking for a science lecture. They're asking: Will this help me get my life back? Will I be the person it works for… or the person it doesn't? How do I decide without being misled by hype, fear, or my own desperation? Those questions are valid. They're also heavy, because the stakes are high: the treatment is expensive, travel can be intense, and the emotional cost of hoping—then not getting results—can be brutal. Andrew's baseline: what his stroke took at the start Andrew's stroke most impacted his right side. Early on, he had: No use of his right arm or hand A weaker right leg Right foot drop A slight speech impediment He worked hard to walk again quickly, using practical supports early (including an elastic extension on his shoe to help keep his foot up). But his bigger mission was clear: find ways to complement rehab—because medical staff couldn't give him a timeline, and he felt a “lack of hope” from their perspective. That's a common moment for survivors: you're doing the work, but you also want a map. The “complement” phase: why hyperbaric helped, even without perfect measurement Before etanercept entered the picture, Andrew leaned on what had helped him before: hyperbaric oxygen therapy (HBOT). He had a history of a brain tumor and had used hyperbaric previously for healing, so he rented a soft-shell chamber at home for three months and went in daily for 90 minutes. Andrew was careful with his claims: he couldn't measure physiological changes in real time at home. But he could measure something important, his ability to cope. HBOT became a daily “warm cocoon” where he could breathe oxygen-rich air and calm his nervous system. For him, that mental-health benefit wasn't a side note. It was fuel. And when you're rebuilding your life after stroke, fuel matters. The etanercept decision: hope, uncertainty, and the reality of the “roll the dice” problem Andrew discovered perispinal etanercept through a media story about Dr. Tobinick's clinic, and after about a year, decided he needed to know he'd tried everything he reasonably could. He crowdfunded to afford the trip and treatment. That detail matters because it introduces the single biggest ethical challenge around treatments like this: Even if you try to stay balanced, it's hard not to hang hope on something that costs time, money, energy, and pride. Andrew doesn't tell people to go. In fact, when people contact him now (he's spoken to more than 50), he's careful: He explains it worked for him, but might not work for them He encourages going without expectation He frames it as “knowing you tried everything,” not a guaranteed fix That's responsible guidance from someone who understands how fragile hope can become when it's under financial pressure. What changed fast (and what stayed improved 18 months later) Andrew's report of early changes is striking not because it proves causality, but because it describes specific, functional shifts: Cognitive fatigue and sensory overload He noticed cognitive fatigue dial down immediately. He still experiences it, but it takes far more to trigger now. The most vivid example: on the way to the clinic, he used an eye mask, noise-cancelling headphones, and had medication ready for overload. On the return flight 24 hours later, he didn't need any of it. He stood in the airport like any other traveler. Pain and cramping A persistent cramp in his right calf eased significantly. Emotional regulation He noticed improvement in emotional control, something many stroke survivors quietly struggle with and often feel ashamed about. Hand function and fine motor control His right hand went from feeling like it moved “in molasses” to loosening up. And here's where the “18 months on” part becomes powerful: Andrew recently discovered he could play scales on his clarinet again, covering holes with independent finger movement, something he hadn't been able to do since the stroke. That's not framed as: “etanercept did this.” It's framed as: recovery kept unfolding. “Your stroke recovery doesn't stop. There's no end date.” The PESTO trial: when research challenges your story Then came the PESTO trial results, which (as discussed in your episode) reported that etanercept was not more effective than placebo in the studied group. This is where Andrew's story gets even more human. He didn't just shrug it off. He described feeling guilt, even fraudulence, because he couldn't reconcile the research headline with his lived experience. That response is deeply relatable: when something helps you, and others don't get the same outcome, it can feel like survivor's guilt, especially when people have spent enormous money and emotional energy. A careful theory: the blood–brain barrier question In your conversation, Bill raises a hypothesis, not a proven conclusion that deserves careful attention: If etanercept struggles to cross the blood–brain barrier in general, could certain people have a more permeable barrier due to factors like stroke, surgery, or radiation therapy (which Andrew had)? Andrew himself wonders if radiation could be part of his “why.” This isn't a sales pitch. It's a research direction, a possible explanation for why outcomes might vary so dramatically between people. If that line of thinking ever becomes clinically actionable, it could change the whole decision-making process for survivors, because the question would shift from “roll the dice” to “are you likely to be a candidate?” What a stroke survivor can take from this without being sold to If you're reading this because you're considering a stroke etanercept injection, here are the grounded takeaways from Andrew's 18-month update: Recovery can continue for years. Don't let a timeline kill your momentum. Treatments don't have to be “proven” to feel meaningful, but meaning isn't the same as certainty. Hope needs guardrails. Don't stake your whole future on one intervention. If you pursue something controversial, protect your mindset. Go in informed, realistic, and supported. You deserve respect, not ridicule, for wanting your life back. If you want ongoing encouragement and tools to navigate recovery (and the emotional complexity that comes with it), Bill's work is built for that: Book: recoveryafterstroke.com/book Patreon: patreon.com/recoveryafterstroke This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. Andrew's 18-Month Etanercept Update: Fatigue, Function, and What the Research Says 18 months later, Andrew shares what improved after etanercept fatigue, function, and the tough questions raised by the PESTO trial. Highlights: 00:00 Introduction and Background 06:15 Exploring Treatment Options 08:59 Stroke Etanercept Injection And It’s Impact 12:14 Research Findings and Controversies 17:59 Conversations with Other Survivors 23:26 Reflections on Treatment and Guilt Transcript: Stroke Etanercept Injection – Introduction and Background Bill Gasiamis (00:00) Hey again there everyone. Welcome back to the Recovery After Stroke podcast. Before we get started, a quick thank you to everyone who supports this podcast on Patreon. Your support helps cover hosting costs and after more than 10 years of doing this largely solo, it’s what helps me keep showing up for stroke survivors who need hope and real conversations. A huge shout out to everyone who comments on YouTube, leaves reviews on Spotify and Apple podcasts. has bought my book, The Unexpected Way That a Stroke Became the Best Thing That Happened, and even the folks who don’t skip the ads, thank you. All of it helps this podcast reach the people who are searching for answers late at night when recovery feels heavy. Now today’s episode is a follow-up many of you have asked for. Andrew Stopps is back, and we’re talking about stroke and etanusept injections 18 months on. We’ll unpack what changed for him, what’s continued to improve and how he processed the PESTO trial results that found Etanercapt wasn’t more effective than the placebo. If you’re considering this treatment or you’re trying to make sense of conflicting stories and research, this conversation will help you think more clearly without hype and without fear. All right, let’s get into it. Bill Gasiamis (01:17) Andrew stops. Welcome back. Andrew (01:20) Thank you for having me. It’s good to back. Bill Gasiamis (01:22) It is so good to have you back. The last time we spoke, was March 26, 2024. At least that’s the date that I uploaded the podcast Andrew (01:30) it would have been before that even, probably a couple of weeks before that. Bill Gasiamis (01:34) Yeah, something like that. So a good 18 months since we last spoke. And the original reason why you reached out and kind of we connected was I think because you had found my podcast, I had maybe had a couple of conversations about Etanercept like, and I had no idea what it was, how it worked, if it worked. And then you reached out and said, hey, I’ve had this injection. I’ve tried it. Why don’t connect about it? Andrew (01:36) So a good 18 months. Bill Gasiamis (02:03) And then we connected and we had a really great conversation and that interview has had like 19 and a half thousand views since then. And then what’s been happening a lot about that interview is heaps of people have reached out to me to say, can I speak with Andrew? Can you connect me with Andrew? Andrew (02:23) And he’s people reached out to me because of that. And also they found me on the interwebs somehow and contacted me that way. So I’ve probably been spoken now, well over 50 people. Bill Gasiamis (02:40) Wow, man, that is fascinating. So and what I love about it is that we put out information. What we hope is we hope people make a more informed decision. Right. That’s kind of the idea is like, how do I help people make people make a more informed decision, especially when I haven’t experienced something and I’m trying to get across the benefits or the pitfalls or, you know, what to avoid on a product. It’s just impossible. But You were very gracious as well as you. I’ve interviewed, by the way, a bunch of other about Etanercept. And one of them was Dwayne Simple. Dwayne also gets a few people who I sent to him that are in Canada because Dwayne is in Canada. He’s had Etanercept and it worked out for And then I’ve spoken to another lady from Australia, Karen. who also a shot or two of Etanercept and had positive results. But of course, Etanercept is extremely controversial. And one of the challenges with it is that it doesn’t work for everybody. And there’s only one way of knowing if it’s going to work is to go and get the injection to pay the money and then to kind of roll the dice and see what happens. Now, that’s what we’re going to talk about today. But before we talk about the new Andrew (03:37) Mm-hmm. Mm-hmm. Bill Gasiamis (03:58) research that has come out, the PESTO trial research. Before we talk about that, we’ll briefly talk about your condition, where you started. We’ll have a real short version of that, where you started, what happened, and then how you ended up overseas experiencing Dr. Tobinick’s procedure, and then update us on what happened in the last 18 months. Andrew (04:17) Okay, so I had my stroke exactly four years ago last Thursday. So I’m a four year old stroke survivor now. And my most damage was done to my right side. So I had no use of my right arm or hand at all. My right leg was weak, but it was okay. But my right foot just fell. I had a slight speech impediment. But otherwise physically that was really it for the stroke. And I worked really hard to get myself walking again as quickly as I could. And so when I got home I could walk but I’d had an elastic extension on my shoe to help keep my foot up. And I… From that moment, I was looking for ways to complement my rehab to help me recover fully from the stroke because the doctors and people in the hospital, no one could say to me like how long, how I was going to be, how much recovery, what I could expect, like anything. was just everyone’s unique. And I understand that, but there was a ⁓ lack of like hope from their perspective. So the first thing we did when we got me home was I’d heard, well, I knew that hyperbaric chambers helped healing. And I knew that because I had a, previously had a brain tumor and I used hyperbaric to help me heal from that. It was really, really good. So we hired one, we rented one for three months and had a soft shell chamber at home, which I went in every day. for 90 minutes and it was fantastic. I can’t say how, if that physiologically helped because I don’t have access to an MRI at home or anything. Yeah, I can’t measure it, but it did wonders for my mental health. Like it was brilliant because for an hour and half every day, I got to sit in this nice warm cocoon shell, they do not over me. Bill Gasiamis (06:01) You can’t measure it. Exploring Treatment Options Andrew (06:15) and listen to really nice music and breathe in almost, you know, pure, very heavily oxygenated air. And so it was like meditation for an hour and half. And the hour and a half went just like that. It was so quick. And I was really sad to have to, you know, give it up after three months. But yeah, it very much helped with my mental health during that time. And I mean, It’s hard to say if it helped me physically, but I certainly got back my ability to move my foot. My arm was another beast though, and that took a long time. That took about two months before it even moved slightly before I could just, you know, move it up and down. So getting back the function of my arm was a longer process. So I kept researching online and finding, you know, other ways that I could help myself to recover. That’s when came across the 60 minutes interview with Dr. Tobinick and the clinic and the lady from Australia. Bill Gasiamis (07:17) Which by the way, 60 minutes has taken down. You can only find that on Dr. Tobinick’s YouTube channel now. Yeah, right. So that’s interesting just as a thing that I observed that people might find interesting as well to hear. It doesn’t mean anything perhaps. Andrew (07:24) really? Interesting. Yeah, I mean, yeah, can be anything anyway, so I found that I watched it. I was really really inspired and I thought well I’ve got to know that I have tried everything like if this is how I’m going to be and this was After one year and I was told that you know after three months or That pretty much what I had after three months was was how I was going to be so I figured after one year, I’ve got to try everything. And so I crowdfunded and had about 30 or 1000. Bill Gasiamis (08:13) You raised how much? US, New Zealand dollars. Andrew (08:22) Yes, so that was to that was to fly that was for the flights accommodation the shots like the whole the whole package And yeah, and we flew out in in February Last last year 2025 Was it last year? can’t remember Bill Gasiamis (08:37) I did 20, 24, 18 months ago. Stroke Etanercept Injection And It’s Impact Andrew (08:40) 2024. And yeah, had the shot and it was it was amazing how fast I found things start to to wake up and recover. By then I had had more movement in my arm, but my hand was very sluggish. And I really didn’t have any fine motor control at all. ⁓ So yeah, that was the 32nd story of Andrew’s stroke recovery. Bill Gasiamis (09:04) Yeah, that’s a cool story. So we did a full deeper dive interview for Andrew’s story, an hour and 18 minutes worth of conversation. And the link to the original interview with Andrew about Etanercept will be available in the show notes, right, and in the YouTube description of this video. So anyone who wants to go back and watch that can do that as well. Now, like I said, it’s had 19,000 views. It’s 521 likes and it has just a ton of comments, just a ton, a ton of comments. Now, one other thing that has happened since then is I haven’t been able to find people who are willing to talk about Etanercept who did not have positive results when they went to Dr. Tobinick’s clinic. just, people don’t want to be interviewed if it’s about that. It seems as though it’s been really hard, right? So. I can’t give this balanced view of here’s somebody who has had good results, here’s somebody who hasn’t had results. They comment on the YouTube comments and they send me emails about it, but they don’t really tell me whether or not they will join me on the podcast to discuss it properly. recently the Griffith University study came out about Perispinal Etanercept and it had some positive results. It didn’t find that it was able to help restore certain functions, et cetera, but it did have an impact on pain relief for some people. Now, after that, the highly anticipated study was the one from the Flory Institute here in Australia called the PESTO trial. I’ll share my screen and I’ll put it on the screen while we chat about it, right? We’re gonna chat about what if. what it found, Andrew, just so that we can bring people up to speed so they can just hear a conversation about it. Bill Gasiamis (10:50) We’ll be back with more of Andrew’s story in just a moment, but if you’re listening right now and you feel stuck, want you to hear this clearly. Recovery isn’t a three month window. It’s not even a one year window. Your brain can keep adapting for a long time. And the real challenge is learning how to keep hope without putting all your hope in one thing. In the second half of this episode, Andrew shares what actually lasted 18 months on. What still improved over the time. And we’ll talk about the biggest question. If the PESTO trial says the Etanercept shouldn’t work better than the placebo, then why do some people still report a night and day difference? Bill Gasiamis (11:30) OK, so this is the PESO trial. Now, I interviewed recently ⁓ Vincent Thijs the doctor who headed the study. but the Flory Institute is basically reporting on his findings. He has presented these findings at stroke conferences around the world. And what was interesting was that this study started in, I think, 2018. And then because of COVID had to be paused, amongst other things. And then finally, all the research was reviewed and it became available at the beginning of 2025. And then it’s been out probably for about seven or eight months now. Stroke Etanercept Injection Research Findings and Controversies And what they found was that the, and they’re being a little bit provocative here calling it a miracle cure, but what they found was that a perispinal etanusept, the arthritis drug, ⁓ was not effective in treating people that were experiencing symptoms because of a stroke anymore. than the placebo. So what they found was that the people on the placebo who ⁓ received the placebo, 56 % of them had a positive result from the placebo as opposed to less than 56 % of people who were actually using the Etanusept. And the reason being, they say, is because the drug doesn’t have the capability of crossing the blood-brain barrier to get to where the ⁓ inflammation is and to actually ⁓ decrease the inflammation. In arthritis, for example, the inflammation is in the joints, which are not part of the brain. There is no blood-brain barrier or some barrier that stops the atanasip from going there. And therefore, when people get injected to experience relief from ⁓ the symptoms of rheumatoid arthritis, they do experience that relief sometimes almost immediately, et cetera. And ⁓ as a result of that, the guys published the study and basically concluded that it is not effective and more research needs to be done to understand why or why not it works for some people and why it doesn’t for others. And I’ve had a couple of kind of ideas since then. And I’ll stop sharing my screen now because we can go back to just you and I, Andrew. And I’ve had some ideas as to how do I then talk to people about that, right? So I know I’ve interviewed Andrew, five other people that I’ve interviewed at least who said they had a positive result. And I should tell people there’s people who had a positive result, right? And then there’s the other people on the other side of the spectrum, which are really hostile saying like, it’s snake oil. My idea is that even if you go there and you receive Etanercept and it works when it’s not meant to and it’s just a placebo working because you’ve got high expectations of it working. You need it to work. You’ve invested $30,000. You you’ve traveled half a way across the world. Even if it works and it didn’t cross your blood brain barrier, to me, that’s a tick, right? That’s like. It worked fantastic. People improve their function. They got their life back. The body is very powerful. It can achieve amazing things. Who cares how it did that? A B, your blood brain barrier might be compromised. So there is a thing called leaky gut. We’ve heard about leaky gut. It is a compromised gut barrier which allows toxins to escape the gut and get into the blood. and causes a lot of autoimmune conditions. The same thing is possible for the blood brain barrier. If you’ve got a really compromised blood brain barrier because you’ve had a stroke or you’ve had brain surgery or something like that, it’s possible. Andrew (15:47) we’ve had radiation therapy, which I have. Bill Gasiamis (15:50) or you’ve had radiation therapy because of previous medical conditions, et cetera, then there could be a more permeable blood brain barrier, which enables the Etanercept to actually penetrate it and get to the root cause of the stroke inflammation or the root location of the stroke inflammation. And therefore, some people through no… ⁓ you know, through no fault of their own, I either have a really healthy blood brain barrier and Etanercept can’t cross it or have a compromised blood brain barrier and Etanercept can cross it. And therefore they experience positive results. But the issue then is how do we know? How can we work that out for people, you know, before they go and drop 30 grand on a treatment that they may not get a result for. Now. That’s my thinking about it, right? But I still send people to you and I still send you these studies as they come up, just so that I can say, Andrew, I need your feedback. I need you to talk to me. I need you to tell me something. Like, where do you stand on all of this? I’m going to keep sending people to you who reach out to me to speak to Andrew because they’re interested. So like, how does that conversation go in your head and then with the people that you connect with? Andrew (17:09) Okay, so having having been a teacher, career teacher, I’m really careful of what I advise people like I would be really careful what I advise my students. So I never say to people, yes, you’ve to do it because it worked for me. God, do do it, do drop it again. I never ever say that I tried to give them the balance for you. And and even though it worked for me, I make sure it’s I’m very clear that they understand that it worked for me, but it might not work for you. Conversations with Other Survivors So you’ve got to go like I did and don’t go with any expectations. Just go, just know that you’ve tried everything you can to help your recovery. That’s all. And so that’s how that conversation usually goes. They ask me lots of questions about what it feels like, what the place is like, what Dr. Tobinick was like. just all the sort of the mechanical questions around it. But generally, it’s, I don’t know whether I should go. And it’s also, I want to go, but my family don’t want to go. And I can’t go because they don’t support me, because they think it’s snake oil. Bill Gasiamis (18:18) Okay, that’s an interesting conversation. So I often try and advise stroke survivors to be careful who they share information with. Not saying that you shouldn’t share information with your loved ones and your family members after a stroke. What I’m saying is like, even in situations where things are not that critical, where you’re not talking about spending 30 grand, I’m just talking about people who have the experience sometimes Andrew where they say, oh, I wanna try this meditation thing, you know, and. somebody hasn’t meditated before, thinks it’s woo woo and says, don’t worry about that stuff. What do you wanna be? Like a hippie or something? There’s those types of people who hang out in our world who do intervene with things that we’re curious about and we wanna kind of shift away from perhaps old habits to new habits, especially around alcohol as well. I found that people would go, aren’t you gonna have one drink? Like what’s the point of going out if we can’t have a drink? It’s like, dude, like I’m a completely different version of myself. I’ve had a stroke, I can’t drink. But understanding how to deal with people like that is a bit of an issue. So then you’ve spoken to about 50 people who have either gone or not gone. Like have some people gone and contacted you and said it worked and some people gone and contacted you and said it hasn’t worked. Andrew (19:40) Yes. Yep. And I’ve. The contact normally starts to go quiet once they actually go, whether it works or doesn’t work. And I usually just get a quick message saying, hey, I went and it worked and that’s great. And, you know, have a good life. You know, I don’t want to keep bugging them. But the people that it didn’t work for have been pretty gutted. Bill Gasiamis (20:03) Right. Andrew (20:04) Because I’ve, you know, even though I’ve tried not to make it something they hang all their hopes on, you know, they still do to a certain extent. And so they come back pretty, not bitter or angry at me, just at the situation, that it didn’t work. And they don’t know where to turn next. Bill Gasiamis (20:22) So they might’ve had all their hopes kind of set on this working, all their eggs in one basket, so to speak, didn’t work and now they feel like maybe they’ve lost hope or they haven’t got another alternative or option. Andrew (20:35) Yeah, yeah. And what I’ve learned in the last 18 months is that your stroke recovery doesn’t stop. There’s no end date. So when you’re told in hospital that after three months that’s what you’ve got, no, no. doesn’t, like your brain is constantly evolving and working and learning and repending itself. If you want to work something and exercise something and rehab part of your body, eventually it’s going to improve. Even if it’s only by a little bit and it’s really slow, it’s going to improve. Bill Gasiamis (21:09) Yeah. So you’ve been 18 months down the track. One of the questions I got asked recently was, does the procedure need to be repeated every couple of years? Does it last? What have you found about how you have changed or experienced your body in the last 18 months? ⁓ Tell us first what you got back and how quickly and then what that led to, what you were able to achieve as a result of what you got back. Andrew (21:34) Yeah, okay. So, um, immediately the things that came back is is that my cognitive fatigue like just just lowered like straight away. Um, and I was when I had the shot, I was exhausted because they take it through a battery of tests. So I like was an hour and a half of tests. And so I was I was done. I was ready to go lie down. Um, And that just lifted like straight away and it didn’t come back. I still get cognitive fatigue now, but I really have to be doing stuff that that really taxes my brain to do it. And or I have to be really tired. But before I had the injection, I would get I would be on the verge of fatigue all the time. So it wouldn’t take much to push me over into it. So that was gone. I had a ⁓ really nasty cramp in my right calf that never went away. That went away. That literally just dialed down as I was sitting there after the shot. the emotional control also came back. Bill Gasiamis (22:42) Uh-huh. Andrew (22:43) which was good. Now, for me, I was, for the first shot, I was only in Florida for 24 hours. So we flew down from Memphis and I had the shot the next day and then we flew back that afternoon. So when we flew down, because of my cognitive fatigue and sensory overload, I had eye mask, had noise-canceling headphones, had like, lorazepam in my pocket. Like, you know, I had all the, you know, all this stuff to, you know, save my senses. When we flew back, I didn’t need any of it, and that was 24 hours later. So I just stood in the airport like any other traveler. And that was… Reflections on Stroke Etanercept Injection Treatment and Guilt Bill Gasiamis (23:26) Yeah. Andrew (23:28) That was the biggest sign that something profound had happened. Bill Gasiamis (23:33) Yeah. Andrew (23:34) The other thing was that my hand, my right hand went from feeling like it was sort of like moving in molasses really slow to loosening up and being more independent. And I found only a month ago that I was able to start to play scales on my clarinet again. So I can move my fingers independently. I could cover the holes with my clarinet here. Bill Gasiamis (23:52) Wow, man. Andrew (23:57) I can the holes in my fingers. It’s something that I haven’t been able to do since the stroke. To be able to play the thing, to be able to just play a scale, just says to me, at some point in the future, you’re gonna be able to play the thing again. Bill Gasiamis (24:11) So things are still improving. Your function is changing still. you, being able to play the clarinet, would you can attribute that to a tenor sept that long ago or just things getting better? Andrew (24:26) I think because it was if I come home and was able to play the clarinet then I would have a definite causality you know so I would rather say the definite yeah it was a tenor step that did it because before I went away I couldn’t even you know I couldn’t pick up things one more right hand so but because it’s been 18 months I think it’s because that that skill has come back Bill Gasiamis (24:50) Yeah, okay. What about work wise? Were you working or not working before the injection? Andrew (24:57) No, no. So I was able to go back to relief teaching. The classroom as a music teacher is ⁓ in a high school is too busy and there’s too many moving parts. So that’s not something I’ll be able to do again, at least not in the foreseeable future. And I don’t know if I want to now. Bill Gasiamis (25:11) Wow. Andrew (25:20) I have done some relief teaching. There are days where I’m in a school and I just feel that it’s a bit too much. And that could be because I had a bad night the night before or it was hot and I couldn’t sleep. And that wasn’t like that before the stroke. yeah, coming up with a new career now has been an interesting journey itself. Bill Gasiamis (25:41) Yeah. So there isn’t a need for another injection or anything like that. Nobody ever told you about another injection or what will happen in two years or anything like that. Andrew (25:51) No, If I can go there and get one, if I think it’s going to make even more improvement, because I had improvement from, you know, from the first. But yeah, there was no compelling sort of needs to go back. And I’m thinking that I probably would like maybe to have a second one, a second trip there and have. having the shot but ⁓ I don’t know I’ll see how my improvement goes. Bill Gasiamis (26:20) Yeah, okay. Andrew (26:22) It’s so hard to One of the things I did do, I had an MRI about two months ago. And it was an MRI to check the status of my tumor and to see where it was. And obviously they also had a look at the stroke site. And comparing the stroke site now to when it was taken when I had the stroke. there’s a day and night difference. Whereas I had a hole in my brain after the stroke, all I had was a little bit of glial, called glial scar tissue. So scar tissue of the brain cells, a little white line in my brain. ⁓ Bill Gasiamis (27:08) as opposed to a round circle of what appeared to be offline or dead brain cells. Yeah, which, you know, it sounds like to me, it’s like where the inflammation was, that area they usually call, they often call, sometimes called the penumbra, which is the area that’s able to be rehabilitated, which is around the site of the stroke, which is offline but not dead, which HBOT targets, the right kind of, Andrew (27:15) Yes. Yeah. Bill Gasiamis (27:38) hyperbaric oxygen therapy can target those as well and try and reduce them. So day and night, like a proper difference between one and the other. Andrew (27:47) Yeah, I was expecting to see when I saw the scan, know, where my brain tumor was and also the big hole and the hole was gone and there was just this like, this is a little, a little line there with scar tissue. Bill Gasiamis (28:01) Yeah, fabulous. How long has the brain tumor been there for? Andrew (28:05) 20 years. Bill Gasiamis (28:07) Okay, and what does it do just sort of sit around and ⁓ Andrew (28:10) Yeah, so ⁓ what happened is it just gradually grows bigger and bigger and bigger and then eventually if you don’t get it treated, it crushes your brain stem and that kills you. So I had mine irradiated 20 years ago and it’s got growing and it’s just started dying off and now it’s just like a… dead mess in there and they check every four years to make sure it hasn’t done anything naughty and It hasn’t so they actually said of this last scan look it hasn’t changed in the last 12 years, so no more scans Bill Gasiamis (28:41) I hear you, okay. So it’s benign now. Andrew (28:46) Yeah. Bill Gasiamis (28:47) Yeah, okay. So you’ve through the rigor, mate. You’ve had an interesting neurological experience, Andrew (28:54) Yeah, yeah, yeah, yeah, feels like my brain’s out to get me. Bill Gasiamis (29:00) Yeah. Well, seems like the interventions have been really helpful in prolonging your life and then your life experience, like how you go about life. So as far as you’re concerned, like it’s all it’s all. You know, it’s been a good outcome, both both interventions. Andrew (29:19) Yes. Yeah. Yeah, I think so. I mean, my biggest challenge this year has actually not been the stroke or the brain tumor, but it’s been the medications for stroke to prevent another one. So my stroke was caused by an overactive adrenal or adrenal glands producing too much aldosterone. Bill Gasiamis (29:31) What man which man say you want? Andrew (29:43) And that was only diagnosed and found last year. So What was happening is that my body was? Was was keeping salt it was it was send my blood pressure sky-high and then crash it down And for 10 years we thought that was anxiety. But what it was was that because my blood pressure wasn’t consistently high, I could go to the doctors and I could be normal. And then my other doctors didn’t have high blood pressure. It was not consistent. So I was just treated for anxiety and given a sort of a low dose blood pressure medication. But actually what it was is both glands like over producing this hormone and that’s what gave me the stroke. So they’ve they’ve given me a hormone suppressant which helps, but they’ve been trying to. to juggle multiple types of blood pressure medication to also bring my blood pressure down to a consistent normal. And so up until about three weeks ago, my blood pressure was still all over the place. And they had me on a really nasty cocktail at one point this year where I literally could not function. I couldn’t even get up. It suppressed my whole system so much. that every time I stood my blood pressure would drop 50 points and I would almost pass out. So I was like a zombie. ⁓ It was just the combination of too many blood pressure medications at once. And finally, I’ve seen a different specialist and he changed my medication and I’ve just got one little pill at the minimum dose and it’s actually stabilized my blood pressure to normal. Bill Gasiamis (30:51) All right. Righto, that’s good. Andrew (31:18) So like when I took it today, was 122 over 72. So it hasn’t been like that for I don’t even know how long. Bill Gasiamis (31:25) Yeah. Fantastic, what kind of stroke did it cause? Andrew (31:31) are ischemic, so a clot. Bill Gasiamis (31:34) ⁓ huh, okay. Wow, man. What an interesting journey you’ve been on. And this insight into Etanercept and how and why it might work for some people and not for others is probably helpful for it again, for a whole bunch of people to hear and kind of get a better understanding about scientifically speaking, Etanercept is not a viable solution for people who have had stroke and there will be some people who will become all, what’s the word? Like they will, they’ll be all, this is snake oil stuff. And then there will be people who brag about it as being the best thing they’ve ever done, which seems to be kind of the camp that you’re in. I think, no, no, no, no. I mean, it’s one of the best things you’ve ever done with regards to your stroke recovery, right? Andrew (32:18) I don’t feel like complaining about it though. Yeah, yeah, and I found that when I got the results for the for the pesto test I really had to do a lot of soul searching because because I couldn’t explain to myself Why it seemed to have worked for me and yet the study was saying hey, doesn’t really have any effect and and I had to to Bill Gasiamis (32:36) Wow. Did you feel remorse or guilt about that? Wow, Wow. Andrew (32:47) Yes, very much. I felt like a fraud. Because why? I couldn’t explain how I had such a huge night and day difference. And that couldn’t be placebo and it’d be still working 18 months later. Bill Gasiamis (33:08) Yeah, I think our hunch about the blood brain barrier is where the research needs to go. And I don’t know how you investigate the blood brain barrier. But if you can go there and investigate the blood brain barrier and if you can understand who has a compromised blood brain barrier and therefore. Andrew (33:15) Yeah. Bill Gasiamis (33:31) due to a compromised blood-barrier barrier, a candidate for a Etanercept I think that’s kind of where it needs to go. Because the biggest issue that people have with clinics who offer a Etanercept perispinally, like Dr. Tobinick’s, the biggest issue that people have that makes it hard for them to make a decision is will I be the right candidate? Will I be the one who will it work for? Or will I be the one that it doesn’t, you know? But I… I find it very fascinating that you would respond that way, that you would feel guilty and remorseful that it worked for you and the pesto child says it shouldn’t have. Andrew (34:10) I feel guilty that it worked for me and didn’t work for someone else. You know, as well. Yeah, yeah, I mean, it’s like survivor’s guilt in a way. Yeah, that’s that and that’s how I felt. so the way I’ve thought of it is, well, OK, if it was placebo, it worked for me. Bill Gasiamis (34:14) Yeah. just wishing for the best for everybody. Yeah, I can relate to that. Yeah. Andrew (34:37) like it just it worked for me whatever it was it worked for me so and that’s that’s that’s all I can all I can say but I think this blood brain theory is is a good one and I would like to I would like to research and understand what what makes the brain leaky like what what events can make your brain Bill Gasiamis (34:41) Yeah. Yeah. Andrew (35:00) ⁓ better suited to receiving Etanercept Like for me, probably the main cause could have been the fact that I had radiation on my brain years ago. Bill Gasiamis (35:05) Yeah. Andrew (35:13) Or it could be that I have a high blood pressure for 10 years. Or it could be I have my appendix out when I’m 17. But I would like to do some research into what it is, what factors make people more likely to have a leaky brain. Bill Gasiamis (35:17) Who knows? Yeah, I think that’s a great thing. I want to research that too, because I have known about it. I’ve understood it. I appreciated that I might be somebody who has had a leaky brain because of the strokes that I experienced, the brain surgery and all the stuff that I went through. And I know that if you restore the blood brain barrier, you can really decrease the fatigue that happens to people after a stroke. And you can make it impenetrable again to toxins. and heavy metals and all that kind of stuff, which is often the cause of real chronic neurological fatigue, even in people who haven’t had a stroke, who are, quote unquote, normal. So that’s fascinating. I really appreciate your continued willingness to have conversations about this topic and sharing your story more than once with me. And then also being being an ear to the people who are curious about whether or not they should go down this path and then kind of just like, you know, being honest about your story, sharing what happened to you, what you experienced and even your own reservations because I don’t think you have anything to, and you probably know this cognitively anyway, right? You don’t have anything to be guilty about or feel bad about or. anything like that. But I understand why emotionally you might go down that path because you’re a guy that cares deeply for other people. You appreciate how hard it is for people to go through stroke and you wish them the same solution or other solutions that you had so that we don’t have to suffer. I know exactly what’s behind it. Andrew (37:08) Yeah, yeah, that’s exactly right. Yeah. Bill Gasiamis (37:12) Yeah. Well, hopefully this continues the conversations to give people more things to think about. Leave us a comment in the YouTube comments section. Reach out via email. Yeah, drop us a comment. Reach out to us and we’d be happy to continue the conversation, support you, guide you. Just being here and I don’t know, help you make a more informed decision. That’s all we can do. We’re not going to suggest. Andrew (37:35) Yeah, definitely. Bill Gasiamis (37:41) that you should or should not go and experience Perispinal Etanercept one way or another. Bill Gasiamis (37:46) Well, that was Andrew Stopps again. What a fascinating conversation. If today’s episode connected with you, I’d love to hear your thoughts in the YouTube comments, especially if you’ve looked into Etanercept Try it. I decided not to. Your experience can help someone else make a more informed decision. And if you found this helpful, please subscribe on YouTube and follow the podcast on Spotify or Apple podcasts. Reviews and comments genuinely help more. stroke survivors find these conversations. If you want to go deeper, you can grab my book at recoveryafterstroke.com slash book. And if you’d like to support the podcast and help keep it going, you can join us on Patreon at patreon.com slash recovery after stroke. Thanks again for being here. You’re not alone in this recovery journey and I’ll see you in the next episode. The post Stroke etanercept injection 18 months on: Andrew's update after the PESTO trial appeared first on Recovery After Stroke.

PESTO Trial Results: What Stroke Survivors Need to Know About Perispinal Etanercept If you've spent any time in stroke recovery communities, you've probably seen the same pattern: a treatment gets talked about with real intensity, people share personal stories that pull you in, and suddenly you're left trying to sort hope from hype from “maybe.” When the decision also involves significant cost, that uncertainty can feel even heavier. That's exactly why I recorded this episode: to help stroke survivors and their families understand the PESTO trial results in plain language without drama, without attacks, and without jumping to conclusions. In this interview, Professor Vincent Thijs explains what the PESTO trial set out to test, why it was designed the way it was, and what the results can (and can't) tell us about perispinal etanercept in stroke recovery. The real problem: not “hope vs skepticism”… it's confusion If you're a stroke survivor, you're already doing something heroic: you're living inside a recovery journey that demands patience, grit, and constant adjustment. The challenge isn't that you “don't want to believe” in something. The challenge is that it's genuinely hard to make an informed decision when: People report different outcomes Online conversations become polarised fast Scientific studies use unfamiliar language The same treatment can be described in completely different ways depending on who you're listening to My goal here isn't to tell you what to do. It's to help you think clearly, ask better questions, and understand what the best available evidence from this trial actually tested. What the PESTO trial was trying to investigate (in simple terms) Professor Thijs explains that the PESTO trial was designed in response to strong community interest. Stroke survivors wanted to know whether the way perispinal etanercept is currently administered in some settings could be demonstrated to work under the standards used for medicines to become widely accepted as part of routine care. So the researchers designed a randomized, placebo-controlled clinical trial. In this type of study: A computer assigns participants to either the treatment or a placebo Participants and clinicians are kept “blinded” (they don't know who got what) Outcomes are measured in a consistent way at set time points In the PESTO trial, the focus was on stroke survivors with moderate to severe disability and reduced quality of life. The primary question was straightforward: Does quality of life improve after one or two injections compared with placebo, over the measured timeframe? Why this study looked at quality of life (not one symptom) One key detail Professor Thijs highlights is the design choice: the trial didn't only target one issue, like pain or walking. It aimed to be more “pragmatic,” reflecting how treatment is used in real-world settings where people seek help for different post-stroke challenges (mobility, fatigue, speech, cognition, pain, and more). That means the main outcome wasn't “Did walking speed improve?” or “Did pain reduce?” It was broader: Quality of life at 28 days And again after the second injection timeframe (56 days total) This matters because your results can look different depending on what you measure. A trial targeting one symptom might see a signal that a broad quality-of-life measure doesn't detect (and vice versa). What the PESTO trial results found In Professor Thijs' words, the trial did not show a difference in quality of life between the treatment and placebo groups at the measured time points: No clear quality-of-life improvement at 28 days No clear improvement after two injections at 56 days That's the central outcome. But there's another finding that grabbed my attention—and it's one many listeners will find surprising. Quote block (mid-article): “We saw that 58% of the people also had that improvement [with placebo] and 53% had it with etanercept… our initial guess was very wrong.” — Professor Vincent Thijs The “placebo signal” and why it matters A strong placebo response doesn't mean “it was all in their heads.” It means that in a blinded clinical trial, people can improve for multiple reasons that aren't specific to the drug itself, such as: Expectation and hope Natural fluctuations in symptoms The impact of being monitored and supported Regression to the mean (symptoms often move toward average over time) The structure and attention that come with trial participation Professor Thijs describes how, during the blinded phase, participants reported improvements in a variety of areas (like sensation, vision, speech). The crucial point is: the team didn't know who had a placebo or an active treatment at the time, which is exactly why blinding exists. For you, the listener, this is a reminder of something empowering: Personal stories can be real and meaningful—and still not answer the question of efficacy on their own. “Am I a candidate?” The trial's honest answer: we don't know how to predict it (yet) One of the most important parts of this conversation is the desire to identify who might benefit most. Professor Thijs explains that the team looked at subgroups (for example: age, sex, severity, diabetes, time since stroke). In this trial, they didn't find a clear subgroup where the treatment stood out as reliably beneficial compared with placebo. He also adds an important caveat: subgroup analysis is difficult, especially in trials that aren't extremely large. So the absence of a clear “responder profile” here doesn't automatically prove none exists—it means this trial didn't reveal one. What this episode is (and isn't) saying Let's keep this grounded and fair. This interview is not about attacking any person, provider, or clinic. It's not about shaming stroke survivors who tried something. It's not even about telling you that you should or shouldn't pursue a treatment. It is about this: Understanding what the PESTO trial tested Understanding what the results showed within their timeframe Knowing the limits of what the trial can conclude Using evidence to reduce confusion before making big decisions A simple “clarity plan” before you decide anything big If you're considering any high-stakes treatment decision, here's a neutral, practical way to move forward: 1) Ask: “What outcome matters most for me?” Is it pain? walking? fatigue? speech? cognition? daily function? quality of life? A treatment might be studied for one outcome and discussed online for another. 2) Ask: “What does the best evidence say—specifically?” Not “Does it work?” in general, but: In what population? Using what method? At what dose? Over what timeframe? Compared with what? 3) Ask: “What are my options and trade-offs?” Talk with a qualified healthcare professional who understands your medical history, risk factors, and rehab plan. Ask about: Potential risks and side effects Opportunity cost (what else could you do with the same time, money, and energy?) Evidence-based rehab and supports that match your goals Listen to the full interview If you want the clearest explanation of the PESTO trial results—from the lead researcher himself—listen to the full episode with Professor Vincent Thijs. And if you'd like to support the podcast (and help keep these conversations going for stroke survivors who need hope and clarity): Bill's book: recoveryafterstroke.com/book Patreon: patreon.com/recoveryafterstroke Medical disclaimer This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. PESTO Trial Results (Etanercept After Stroke) | Interview with Professor Vincent Thijs Confused about perispinal etanercept after stroke? Prof Vincent Thijs explains the PESTO trial results clearly, calmly, and evidence-first. More About Perispinal Etanercept: Etanercept Stroke Recovery: Wesley Ray's Relentless Comeback Dwayne Semple's Remarkable Stroke Journey and Perispinal Etanercept Etanercept for Stroke Recovery – Andrew Stopps Support The Recovery After Stroke Podcast on Patreon Highlights: 00:00 Introduction and Overview of the PESTO Trial 04:19 Design and Objectives of the PESTO Trial 11:23 Recruitment and Methodology of the Trial 18:31  PESTO Trial Results and Findings 24:28 Implications and Future Directions for Research 32:15 Conclusions and Final Thoughts Transcript: Introduction: PESTO Trial Results Bill Gasiamis (00:00) Hello and welcome back to Recovery After Stroke. Before we get started, a quick thank you to my Patreon supporters. Your support helps cover the hosting costs after more than 10 years of me doing this show solo. And it helps me keep creating episodes for stroke survivors who need hope and practical guidance. And thank you as well to everyone who comments on YouTube, leaves reviews on Spotify and Apple podcasts. buys the book and even to those of you who don’t skip the ads. Every bit of that supports keep this podcast going. Now today’s episode is about the PESTO trial results and I’m interviewing Professor Vincent Theis. If you’ve ever felt confused by the conversation online about perisponal antenna sept, some people sharing positive experiences while others are feeling disappointed and plenty of strong opinions in between, this episode is designed to bring clarity. We talk about what the PESTO trial set out to test, how the study was designed, what it found within the measured timeframes and what the results can and can’t tell us. Just a quick note, this conversation is educational and not medical advice. Always speak with a qualified health professional about your situation. All right, let’s get into it. Professor Vincent Dase, welcome to the podcast. Vincent Thijs (01:24) Thank you for having me, Bill. Bill Gasiamis (01:26) I’m really looking forward to this conversation. Atenosept is one of the most hotly discussed topics in stroke recovery. And there’s a lot of misconceptions about whether or not it is or is not efficacious. And while there’s a lot of anecdotal evidence where some people have had positive outcomes from injections, there’s also a lot of people’s feedback, which is very negative about their experience with the Etanercept injections and the lack of results. So today, the reason I reached out is because I wanted to get to the bottom of the findings of the PESTO trial. And I’m hoping that you can shed some light on that. The first question basically is, can you start by explaining in simple terms what it was that the PESTO trial set out to investigate? Vincent Thijs (02:22) All right. The PESTO trial was in response to community members, stroke survivors, wanting to find out whether the current practice of administering Etanercept has done in the U.S. in private practice. In Denmark, I hear there are some sites that provide this treatment. Whether the treatment and genders can be actually proven according to the standards that we use in the pharmaceutical industry to get it to become accepted as a standard of care treatment. For that, you need to do what we call a randomized controlled clinical trial, preferably two that show evidence that treatment does what it’s set out to do. And that’s why with this background and the community pressuring the minister several years ago, Mr. Hunt at the time, to fund a trial that would help answer that question. Design and Objectives of the PESTO Trial There was a call was set out to do this trial and several groups in Australia applied and then an independent committee decided to award the trial to the PESTO study group. And then we tried to design this trial to give an answer. So it’s mostly about people that have moderate to severe disability after their stroke that have reduced quality of life. And We wanted to know, does their quality of life improve when Etanercept is administered? And we wanted to test whether one or two injections were needed. Because that’s what we heard from stroke survivors that from Australia and internationally that went over to the US. Well, this is how it’s done. You get one or two injections and there was a paper that had shown big effects with one injection. So that was the primary endpoint, but then we also looked at whether two injections could help. And when you design a trial, you have to make a decision, will we focus on people with. pain after stroke, or will we look at people who have mobility issues or speech issues or cognitive issues? And we saw that current clinical practice actually was people with various impairments after stroke were accepted and received the treatment. And what would have been the advantage of doing say only mobility or only pain? Well, you can then look at the outcome of pain or mobility, does it improve? Or is your cognition improved? But because we wanted to be pragmatic and we know that recruitment in clinical trials needs to reflect how is current practice. So we thought let’s put in all the people with moderate to severe disability, whatever their impairment after stroke and reduce quality of life. And then we looked at quality of life as an outcome rather than an individual impairment. And so what we did then was to use the randomized technique and where it’s left up to the computer to decide what treatment a person will receive, the active Etanercept or a similar looking placebo, and then look at 28 days and we had to make a decision what makes sense 28 days, what is practical. to see whether that injection then had improved quality of life. And then we did another injection again with a placebo or the active drug. And then after 28 days again, we looked again whether that had made a difference. So we have people that had received two times the placebo, one time the placebo, and one active injection. And then we have people that had received two active injections. And then we were able to compare those and see whether they had made bigger improvements if you receive two injections versus one or zero. Unfortunately, we couldn’t show a difference in quality of life at 28 days. And we also couldn’t show an improvement at 56 days after people had two injections. But that was in a nutshell how we designed and the background of the study. Bill Gasiamis (07:25) So the main difference then between the Griffith University study and your particular study was that they did go after a specific improvement in one area, I believe. it in? Okay. So although those guys went after pain, you guys went after just a general improvement in quality of life after the injection and your stroke survivors. Vincent Thijs (07:39) Mostly, think. Bill Gasiamis (07:54) would have been as far as 15 years post stroke. Is that right? Vincent Thijs (07:59) Yes, correct. We wanted to have people early after stroke between one and five years, and then also between people five to 15 years after stroke. That was also for practical reasons. Once you start trial, you see how good recruitment is, how many people want to participate in the study. And we saw that if we went to up to five years. Recruitment was relatively slow. So we added this additional group of people later on after their stroke. that because many people, I’m five years, I’m six years after stroke. Why can’t I get the treatment? And you know, so we also wanted to expand the pool. And that’s also what happens in clinical practice. Current clinical practice, I don’t think the sites and the US and they would refuse the patient six years or so. We just wanted to reflect the people that we see on the website going for this treatment. Bill Gasiamis (09:01) Yeah, yeah. And then the difference between the Griffith trial and your trial as well was the actual dosage of Etanercept the amount that was in the injection. I do believe that your trial was a 25 milligram injection. And I believe that the Griffith University trial was 25 milligram. injection to 50 milligram injection. Vincent Thijs (09:34) Yeah, we just based on what people told us they received when they went to the clinic, also the other sites and then also 35 milligram was chosen because that’s in the patent for the street. Bill Gasiamis (09:49) Okay, I see. So you’re trying to as much as possible mimic what was happening out there in in the private practice Vincent Thijs (10:00) We wanted to answer the question, is current clinical practice, is that beneficial? And that’s what sort of what the call was to do a clinical trial in current clinical practice. You can, you have to make decisions, right? And I think this was the most relevant for a stroke survivor. Bill Gasiamis (10:17) Now that’s really interesting that stroke survivors were able to twist the arm of a minister to get the funding to begin that process of the trial. How long ago did this actually start? Vincent Thijs (10:28) I think it was 2016, 2017 or so. So it takes a while to get the minister and then I think that the trial started in 2019. took a while to complete as well. Bill Gasiamis (10:43) Right understood. Okay So then you recruit people they come along and they go through the trial through the particular trial How does that work on the day do they turn up are they admitted? We’ll be back with more of professor face explanation in just a moment But I want to pause here because if you’ve ever felt stuck between hope and uncertainty, you’re not alone When you’re recovering from stroke, you’re constantly making decisions and some decisions feel high stakes, especially when confronting information that’s conflicting. Recruitment and Methodology of the Trial In the second half of this conversation, we get into the parts that really help you think clearly. What the trial results do and don’t mean, and why placebo responses matter in blinded research, and how to frame smarter questions before you commit time, money, or energy to any path. If you want to support the podcast and keep these episodes coming, You can grab my book at recoveryafterstroke.com/book or join the Patreon at patreon.com/recoveryafterstroke All right, back to the episode. Vincent Thijs (11:51) All right, so we recruited from a variety of sources. So we had kept a log of people that were interested in this. We had a Facebook post in New Zealand, for instance, where we recruited as well. We had people from the Stroke Clinical Registry that were approached. We had a website and people could register their interest if they were doing a search online to participate in clinical trial. So the variety of sources and then we have to determine eligibility that was mostly done either via an in-person visit or remotely via telehealth. We tried to get their medical information, what type of stroke they had. And then we also questioned whether they had this modified rank in scale, the disability they had, the impairments they had from their stroke. so then people came. they were considered eligible, then we scheduled a visit and they would typically come in no overnight stay needed. It was a day procedure that was done. People were then receiving another questionnaire on the day itself to measure their quality of life and other measures like their fatigue levels and how much help they required, etc. And then we proceeded with the injection, which was done. We had bought a special bed that was able to do the, the, the tilting that was required. So we set the people up, injected and then tilted the table. so, we received the drug. It was prepared independently by the pharmacist. So the pharmacist, they took the drug off the shelf or the made the placebo. and they made sure it looked exactly alike. So then somebody from the trial team picked it up from the pharmacist. The pharmacist didn’t tell, of course, what it was. And then the administration happened. So the doctor who administered and the participant did not know what they received. So after the procedure, they were left like this for four minutes. And then after four minutes, people could sit up again. And we waited about half an hour. then we asked them how they were doing, whether there were any adverse reactions, ⁓ and ⁓ then after that half an hour of observation people could go back to their habitual situation. ⁓ it’s a very simple ⁓ procedure to do. Bill Gasiamis (14:35) I believe there was a was there 126 participants Vincent Thijs (14:40) Yes, 126 people participated. had anticipated a little bit more people to participate. So we had hoped 168, but recruitment fell flat after a while and we were not able to find more people to recruit. So we made a decision and then, you know, these clinical trials, they have some funding ⁓ and they require the treatment team to be paid, et cetera, and that ran out. So we had to stop at a certain time. Bill Gasiamis (15:13) Was the study stopped early because of a decrease in the amount of funding or was there an issue with the funding at some point? Vincent Thijs (15:23) Funding ran out. You hire people for a certain amount of years and then you have fewer patients than you anticipate. So you have to stop. Bill Gasiamis (15:32) huh, okay. So would that affect the outcome of the trial? Would you say the lack of funding or the lack of the ability to take the trial further? Vincent Thijs (15:42) Yeah, well, what we had when you do the trial, when you plan the trial, you say, well, this is what we’re going to expect in terms of efficacy. You have to make a guess and say, well, that many people will have an improvement in quality of life if we give them the placebo and that many people will have an improvement in quality of life with the trial drug. And we had thought that about 11 % would improve with the placebo based on an earlier study. And then we had to make a guess because nobody had done this type of study on what Etanosap would provide. But reading the report that was published several years ago now, where 90 % of the people reported improvement in their impairments, we thought, well, Let’s not go for 90%, but a 30 % improvement. And so that was based on that we needed 168 people to participate in the trial. So that was what we call the pre-planned sample size estimation, which is a guess. When we stopped at 126 participants, actually we saw that the results were very different. There was not that 11 % actually in the placebo arm. saw that 58 % of the people also had that improvement and 53 % had it with ethanosab. So our initial guess was very wrong based on some statistical advanced statistical techniques we have. We have quite a lot of power to estimate whether there was a difference. So I think the trial can provide us an answer. It’s large enough to give us an answer about this particular question. Is current clinical practice in these people with this range after their stroke, does it improve? quality of life after a month or after two months. I’m not speaking about early improvement, I’m not speaking about six months down the line. We only can decide what we see in this study. Bill Gasiamis (18:05) So you have some limitations because you can’t have the funding to test one month, two months, six months, 12 months. You have the funding to basically meet the design of your study and then you can report on that. Now what’s really interesting is that the placebo had such a large result. PESTO Trial Results and Findings Vincent Thijs (18:34) What kind of things were people reporting that improved for the people who had the placebo injection?Look, this is, course, when we were in the blinded phase, when neither myself or my colleagues who did these scales, we were totally blinded. And that’s, remember vividly people saying, it didn’t do anything for me. But then there were also people said that they could see again. And so people that had improvement in sensation. Some people had improvement in their speech. there were, we, we observed these things, but we didn’t know whether they were active or placebo. And then surprisingly we had some people in whom we thought, they must have had active drug that turned out to have the placebo, but that’s years after, right? Because it takes a little bit of time to accumulate a sufficient number of patients. And we were only reporting and breaking the blind when the trial was finished. because otherwise you may be biased in all your analysis, et cetera. You don’t want to do that. So you wait until the end of the study to break the blind. And that’s very frustrating for the participants because there were many people that said, I must have had the placebo because it didn’t do anything for me. And there were other people that were, and some people like that, they said, I still want to go to the US. Bill Gasiamis (19:37) I see. Vincent Thijs (19:59) And please, can you tell me if I received a placebo? And I understand it was terribly frustrating for these participants. But we were very strict. No, we don’t want to break the blind. This is against the rules that you have to adhere to in a clinical trial. And so we didn’t do that. Of course, once the trial was finished, we were able to report the results back to the the participants. And then there were some people that were very surprised that they had received the active drug. I remember one person vividly who said, you have to tell me now because I’m going. And then I said, hold off, hold off. And then we told them you had twice the active drug. And so they decided not to go anymore. So you see how From a clinical trial perspective, it’s very important to remain very objective and not being able to see what people have received. From a humane level, of course, I understand it was very important to these people. Bill Gasiamis (21:02) Yeah, that’d be difficult. ⁓ And then I imagine that had the placebo not worked and then the tenisept did work, then there would have been people who would have said, well, I’ve received the placebo. It didn’t work for me. Other people received the tenisept. It did work for them. Why can’t I get the tenisept injection now? Vincent Thijs (21:26) Yeah, and we also had two people, people that had twice the placebo who noticed an improvement and have told me the improvement is still there. Bill Gasiamis (21:35) Wow. Vincent Thijs (21:36) So it. Bill Gasiamis (21:38) That’s amazing. Now was the. Vincent Thijs (21:40) And often that, and I must tell you, often those were relatively little things that seemed to improve both with the placebo and in the active group. And you see that there are changes in quality of life that people have reported, but it happens as well with the placebo. Bill Gasiamis (21:58) Wow. Was the intention of the study that was funded at the very beginning in 2016 by Minister Hunt, was it to determine whether or not this was going to be an effective treatment for people in stroke and therefore to roll it out somehow in the Australian medical system for stroke survivors? What was the thinking for Minister Hunt? Do you know? Vincent Thijs (22:24) Of course, I was not involved in that lobbying to the minister or anything, but it was to bring it on a pathway towards regulatory approval. We know that Etanercept is a relatively cheap drug that you can get ⁓ and is approved already for some indications, especially in people with rheumatoid arthritis, the condition of the joints, but it’s not approved for stroke. And to be officially approved and then potentially re- reimbursed on the PBS. You need to have some trials that have been done such as PESTO. We do different trial phases. One would be a phase two trial and a phase three trial. So phase one is typically in people just to assess the safety and some dosages usually in healthy people. And then a phase two is safety amongst stroke survivors. and preliminary efficacy. And that’s where PESTO was what we call a phase two B trial. And then a phase three trial would then be a trial in many more participants based usually on the results of a phase two B trial. And then usually when you have a phase three trial and it’s convincing and the authorities may approve such a trial. Bill Gasiamis (23:46) So in this case, the phase two B trial, this PESTO trial didn’t find that it’s efficacious. And as a result, there’s not going to be a further trial. Would that be accurate? Vincent Thijs (23:56) Well, based on the findings we have in this particular type of ⁓ way of administering in this particular group of people, I don’t think there’s enough evidence to argue for a phase three trial. It may be that you could say, well, we want to focus on pain because that was more promising. Well, you’ll need to do another trial in that condition. Implications and Future Directions for Research After stroke or maybe within a year after stroke. I mean, there are other possibilities, but at the moment, current clinical practice type trials, I don’t think there’s enough evidence to move forward with that. Bill Gasiamis (24:43) What would the numbers have had to look like for the trial to conclude that there was evidence of efficacy? Vincent Thijs (24:51) Well, I think based on what we have now, you would need to design a much, much bigger trial because there was only a 5 % difference between the placebo and the active group. And actually it was in favor of the placebo. So the placebo did a little bit better, not statistically significant. So it could just be by chance, but you would need probably thousands of people. Bill Gasiamis (25:15) I see. And I imagine there’s not a lot of excitement about funding something like that by the people who fund these trials. Vincent Thijs (25:25) Yes, typically the funders will look at how good is the evidence to pursue this. And if you were a pharmaceutical company on a pathway to development for a drug, you probably would say, well, it looks safe, but it didn’t do what it intended to do. So let’s stop the development of this drug for this indication. Bill Gasiamis (25:45) I say so. I think one of the challenges with the path of administering a TANACEP to stroke survivors is that there seems to be a missing step. And the step to me is determining whether or not somebody is a candidate for a TANACEP. perhaps if we knew more about the stroke survivor, what was actually happening in their particular brain, and we were able to determine some similarities between the people who have had a positive result and we developed a method, then that would make it a lot easier. to say, well, I’m a stroke survivor. I’d like to have a TANACYPT and then go through a process of determining whether or not I was a candidate rather than just guessing whether I’m a candidate or not and then having to pay money to find out whether in fact I was a candidate. Vincent Thijs (26:33) The trial provides a little bit of answers to that. ⁓ You want to identify a marker or a subgroup of people in whom the drug will work particularly well. And so you could look at, and we looked at different things like females versus males, if you’re younger versus older, if you have very severe disability or less severe disability, if you have diabetes, are you early after your stroke or later? That one to five versus six to 15 category. And we could not identify a group in whom the the drug worked particularly well. Now there’s a caveat when you do a clinical trial, it’s really hard to look at subgroups, especially if your trial is relatively small and the PESTO trial is relatively small. So you have to take this with a grain of salt, but it was nothing really promising. that we could identify. So probably you need other markers. If you believe in Etanercept as a drug, you would possibly need to look at what are the levels of TNF alpha, the drug, the molecule that actually is targeted. Unfortunately, there’s nothing like readily available to do that. Could it be that people with a… a stroke in a particular location that would work particularly more than in others, but we don’t have any real way at the moment to do that. Bill Gasiamis (28:08) Okay, so we’re assuming that the people who experience an improvement after they’ve had an attempt to shut that the markers of TNF alpha were lower or higher or Vincent Thijs (28:21) Well, the theory is that they have a lot higher TNF-alpha. Now, as you know, the premise is Etanercept works by reducing this molecule and we have good evidence that it reduces this molecule in the blood, but we don’t have good evidence that it reduces the levels in the brain. That’s where you want it to be. And one of the difficulties and many scientists that work on the Etanercept and ⁓ have said, look, it doesn’t cross the blood-brain barrier. It doesn’t. go against the natural defense that we have to protect the brain against substances that could potentially be harmful for the brain or that have a large size. And the Tandacep we know has a large size would not cross the blood-brain barrier. So it doesn’t reach the brain. And many people look at it with relative skepticism that it actually enters the brain. Bill Gasiamis (29:18) ⁓ And then with regards to rheumatoid arthritis, doesn’t need to cross the blood-brain barrier. It just somehow gets to this, position or the place where inflammation is occurring. TNF-alpha is active and it can easily mitigate the impact that TNF-alpha is causing. In the brain, the brain is protected by the blood-brain barrier and it cannot cross the blood-brain barrier under normal conditions and therefore it can’t get to where the TNF-alpha is. if there’s any TNF alpha, if inflammation is the issue and it cannot resolve it one way or another. So for some people perhaps it can’t resolve it. Now, I don’t understand about Etanercept a lot. I don’t understand exactly how the molecule works, et cetera. But if it was injected into a blood vessel, is that not something that can occur? And if it was, if it can occur, would that then cross the blood brain barrier? Vincent Thijs (30:15) That wouldn’t cause a blood brain barrier, no. You would have to do what we call a lumbar puncture or put a little ⁓ injection into the ventricles and then hope that it would enter the area that is stark where the TNF alpha is elevated. Those experiments have not been done. Bill Gasiamis (30:17) Either. Okay, so a lumbar puncture is probably riskier than… Vincent Thijs (30:44) Well, it’s uncomfortable. It’s uncomfortable and we do it to administer drugs if needed. Some people with brain cancer receive it. There are other trials ongoing in certain areas of stroke where it’s done. Bill Gasiamis (30:58) Then the difficulty is, and my job here is to report back to the community how they should proceed with Etanercept going forward. Now, I don’t expect you to answer that. However, your study probably gives enough information for people to be able to make an even more informed decision than they did before. Previously, what I think was happening is people, and it still happens every day. And I’ve interviewed a lot of stroke survivors who’ve had positive results with Etanercept. The challenge is getting interviews with stroke survivors who have had negative results with Etanercept. That is something I haven’t been able to do. So if somebody happens to be watching and listening to this and they have had the Etanercept shots and they didn’t get positive results, please reach out so that we can share a balanced story of what’s happening out there in the community. Would there be a reason for the community to perhaps begin again to lobby a government or a minister of a government to look at perisponinal tenosept and study it in a different way, like administration via a lumbar puncture. Conclusions and Final Thoughts Vincent Thijs (32:08) I think we need more, probably go back to the drawing table to see whether, because we’re just taking a step back. The idea is that there is inflammation after stroke and we know that there is inflammation after stroke. We don’t, we just don’t know how long it is. We don’t have a good marker. Is it present only for weeks or months after stroke or can it persist for years? The theory is that it persists for years, but if you look at the actual experiments that have been done, it’s really hard to study in humans because we don’t have good tests. But if you look in animals, it’s also hard to do long-term studies in animals, but nobody has really proven that conclusively that there is still after the stroke causes a scar, that process is still really active. Is TNF-alpha years after a stroke still present? Yes, it’s present because we use TNF as a transmitter in the brain or a chemical in the brain, but is it still worth reducing its activity? That’s probably, I think, a bigger question that science needs to answer is to understand that all inflammation piece and the time after stroke that it persists in my Bill Gasiamis (33:35) Yeah, because it could still be the fact that the person has had brain damage. The particular part of their brain that’s damaged has, for example, taken offline one of their limbs and there is no way to recover that once it’s gone. there is no, there may also be no inflammation ⁓ there. So somebody in that situation receiving Etanercept wouldn’t get a result even if it was able to cross the blood-brain barrier because the damage is done and that’s the challenge with the brain is once it’s damaged restoring the damaged part is not possible. Vincent Thijs (34:15) Yeah, look, after this experience with the PESTA trial, I think we need to work on other avenues and I’m not as hopeful with this based on the data that I have seen. Bill Gasiamis (34:28) Yeah Well, my final question then is, are you planning on exploring inflammation and recovery after stroke with any work that you’re doing in the future? Is there any more of this type of work being done? Vincent Thijs (34:46) we’ve just launched a new study, which is not a randomized trial, but it’s trying to get at this common symptom that people have after stroke, which is fatigue and cognitive changes. And one of my post-docs, Dr. Emily Ramech, she’s a physio by background. We just launched what we call the deep phenotyping study after stroke. And we are looking at young people that have had a stroke up to age 55 and we’re taking them into the scanner. We will do a PET scan that’s looking at inflammation. We’re taking their bloods and looking at markers of inflammation and see how that relates to fatigue after stroke. This is between the first month and the sixth month after stroke. That will give us a little bit of timeline of inflammation after stroke. It will give us some information about fatigue, which is very common, but I have no plans at the moment to look at ethanocephaly. Bill Gasiamis (35:53) Fair enough. I appreciate your time. Thank you so much. All right, well, that brings us back to the end of the episode with Professor Vincent Dease on the PESLO trial results. My hope is that this conversation gives you more clarity, especially if you’re felt caught between personal stories, strong opinions, and a lot of uncertainty. The goal here isn’t to tell you what to do. It’s to help you ask better questions and make decisions with your eyes open alongside a qualified healthcare professional who knows your situation. If this episode helped you, please do a couple of things. Subscribe on YouTube or follow the podcast on Spotify or Apple. Leave a review if you can. It really helps more stroke survivors find the show. And if you’ve had an experience you’re willing to share respectfully, positive, negative or mixed, add a comment. Those real-world perspectives help community feel less alone. And if you’d like to support the podcast and keep it going, my book is at recoveryafterstroke.com/book. And you can join the Patreon at patreon.com/recoveryafterstroke. Thanks for being here with me. And remember you’re not alone in this recovery journey. Importantly, we present many podcasts designed to give you an insight and understanding into the experiences of other individuals. Opinions and treatment protocols discussed during any podcast are the individual’s own experience, and we do not necessarily share the same opinion, nor do we recommend any treatment protocol discussed. All content on this website and any linked blog, podcast or video material controlled this website or content is created and produced for informational purposes only and is largely based on the personal experience of Bill Gassiamus. Content is intended to complement your medical treatment and support healing. It is not intended to be a substitute for professional medical advice and should not be relied on as health advice. The information is general and may not be suitable for your personal injuries, circumstances or health objectives. Do not use our content as a standalone resource to diagnose, treat, cure or prevent any disease for therapeutic purposes or as a substitute for the advice of a health professional. Never delay seeking advice or disregard the advice of a medical professional, your doctor or your rehabilitator. program based on our content. you have any questions or concerns about your health or medical condition, please seek guidance from a doctor or other medical professional. If you are experiencing a health emergency or think you might be, call 000 if in Australia or your local emergency number immediately for emergency assistance or go to the nearest hospital emergency department. Medical information changes constantly. While we aim to provide current quality information in our content, we do not provide any guarantees and assume no legal liability or responsibility for the accuracy, currency or completeness of the content. If you choose to rely on any information within our content, you do so solely at your own risk. We are careful with links we provide. However, third-party links from our website are followed at your own risk and we are not responsible for any information you find there. The post PESTO Trial Results (Etanercept After Stroke) | Interview with Professor Vincent Thijs appeared first on Recovery After Stroke.

Gareth checks in on Steve and Eric. Together, they take spooky revenge on a straightlaced grandpa. Then, Eric and Steve plan a themed party for an expecting insect mother. Plus, the follow-up to Ep 211 "Old Man Hitchhiker."See images from the episode here: http://www.heretohelppod.com/post/episode-239Want to call in? Email your question to helpfulpod@gmail.com.PATREON: https://patreon.com/heretohelppodMERCH: heretohelppod.comINSTAGRAM: @HereToHelpPodIf you're enjoying the show, make sure to rate We're Here to Help 5-Stars on Apple Podcasts.Advertise on We're Here to Help via Gumball.fmSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Pesto and Niffy go out on a grand adventure, with a special guest....   Join out Patreon! - patreon.com/u97775911 Music from Dark Fantasy Studio and author/composer Nicolas Jeudy Music from Ovani Sound Intro/Outro Music - "Reaching Horizons" by Alex Atlas (Our GM)

Themen: Fleck weg – Herbstedition [00:21 Min.] | Hilfe – eine Spinne!!! [05:53 Min.] | Gold – sicherer Hafen oder riskantes Geschäft? [12:08 Min.] | Pesto im Test – wie viel Italien steckt wirklich drin? [17:56 Min.] | Kühlschrank richtig einräumen – so sparen Sie Energie und Geld! [27:11 Min.]

Julie Biuso from Shared Kitchen joins us to talk all things pesto.

Themen: Schnäppchenjagd: Kosmetik [00:26Min.] | Bußgeldbescheide aus dem Urlaub - Wenn Inkassofirmen Ärger machen [09:28Min.] | Snus - neue Nikotinprodukte machen abhängig [19:03Min.] | Kann Galeria es schaffen? [26:05Min.] | Pesto im Labortest [34:57Min.]

Les ventes de pesto progressent de 15% par an en moyenne. Un tiers des Français en achètent, pour environ 150 millions d'euros cette année. Il y a trois explications. Ecoutez Olivier Dauvers : les secrets de la conso du 10 octobre 2025.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Les ventes de pesto progressent de 15% par an en moyenne. Un tiers des Français en achètent, pour environ 150 millions d'euros cette année. Il y a trois explications.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Les ventes de pesto progressent de 15% par an en moyenne. Un tiers des Français en achètent, pour environ 150 millions d'euros cette année. Pourtant, c'est gras et cher... Mais il y a trois explications à cela. Cette saison dans "RTL Matin", Olivier Dauvers part à la quête des bonnes affaires et vous livre ses secrets pour éviter les arnaques et devenir un consommateur avisé ! Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Vidcast:  https://www.instagram.com/p/DPmHut4D0vZ/Listeria causes severe and sometimes fatal systemic infections in the very young, in older frail individuals, and in those with weakened immune systems.  Listeria can also trigger miscarriages and stillbirth These recalled salads were sold at the Kroger family of stores including Kroger, Baker's, City Market, Dillons, Fred Meyer, Fry's, Gerbes, King Soopers, Payless, Ralphs, and Smith's in Alaska, Alabama, Arkansas, Arizona, California, Colorado, Georgia, Idaho, Illinois, Indiana, Kansas, Kentucky, Louisiana, Michigan, Missouri, Mississippi, Montana, Nebraska, New Mexico, Nevada, Ohio, Oregon, South Carolina, Tennessee, Texas, Utah, Washington, and West Virginia between late August and early October 2025.Do not eat these pasta salads but return them to any Kroger store for a full refund or replacement. For more information, contact Kroger at 1-800-KROGERS or email customerservice@kroger.comhttps://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/kroger-voluntarily-recalls-two-varieties-deli-pasta-salads-because-possible-health-risk#kroger #salads #bow tie #penne #listeria #infection #recall

In this installment of TPS Reports the Squares discuss performing at Holy Smokes festival, stolen merch, seeing The Effigies at Riot Fest, GWAR beheading the president, the Charlie Sheen documentary, sneaking into movies, sparring combos & Spike Lee joints. Watch the Perennial music video Outro song: "Pesto" by Pudge Smoochie Gang Playlist Term's Album of the Week Playlist Please send questions, stories & whatever else to tpsreportspodcast@gmail.com and feel free to leave us a voicemail at 708-797-3079. The Palmer Squares on Facebook, Twitter, YouTube, Patreon & more Shop for Official TPS Merchandise

Christopher & Jobst im Gespräch mit Chris. Wir reden über langweilige Converge, Raver im Herzen sein, die grandiosen frühen Scorpions, Stimmungsschwankungen, Zukunft nicht interessant finden, unsichtbar zurück in die Kindheit, Michael Jackson mit Slash, eine "Jump in the Fire" EP von Metallica, die erste Spermbirds-LP, dubiose Exportgeschäfte, nebenbei Skaten, sehr früh Bier gut finden, stets bemüht sein, ein riesiger Backstein auf die Motorhaube des Vaters, Dreh- & Trinkflaschen, durch die Saarlouis-Community, die Sporthalle Völklingen, schockverliebt im Homburger Juz, der zutätowierte Choke mit einem Espresso in der Hand, ein Interview mit dem Clawfinger-Typen, das Genre "Fun Macker Hardcore", Used For Nothing, eine Europa-Tour mit pg99, die Idee von Schreinerei gut finden, wie The Office nur mit Rauchen, BWL in Trier abartig scheiße finden, kleines Kiffproblem über der Currywurst-Bude, sehr gut im Telefonmarketing sein, auch mal mit Peter Maffay auf Tour gehen, nur Freunde haben wollen die die Musik verstehen, soweit gar nicht von VW Golf-Fans entfernt sein, Bubbles total gut finden, ein bißchen Berufsjugendlicher sein, Unbeschwertheit verlieren, mal eigener Chef sein wollen, zurecht im Biohazard komisch angeguckt werden, viel bemustert werden, Hauptsache kein Barcode auf der CD, Hüsker Dü ist halt Pop, die Eleganz von Zahn, Felix Gebhards Solo-Projekt, der Botch-Gitarrist bei Russian Circles, jetzt schon mehr sein als je erhofft, gern mit Bohren & der Club of Gore sein wollen, die Patchouli-Frau, ein wenig über Nothing. Tour-Erfahrungen in China, die historische Herleitung von Gedrängel in Zügen in China, ein DOA Konzert in Shanghai, Sauerstoff-Schnüffeln in Mexico City, eine Show auf dem October Fest in Indien, selbstgemachtes rotes Pesto, "Solange man lebt soll man rauchen", mal ne geile Fahrradtour machen, immer wieder versuchen zu lesen, "Good Girl" von Aria Aber, White Lotus mal wieder, der jüngere Bruder von Leslie Mandoki, uvmDrei Songs für die Playlist1) Ein Lied, das der 16-jährige Chris richtig gut fand: HELMET - Iron Head2) Ein Song, der für Chris ein perfekter Hardcore-Song ist: AGNOSTIC FRONT - Victim in Pain3) Der momentan liebste Song auf Crazysane Records: YASS - Nobot

We preserve the flavor of summer with a batch of vibrant basil pesto // Jillian Moore of Mom’s Micro Garden shares the big impact of tiny greens // Shawna Perez of Sasquatch Family Farms brings pork, lamb, and a mission to nourish land, animals, and community // Deborah Tuggle, President of Bite Me Cookies, shares the bold spirit behind her sweet empire // We dive into Paella – with crispy socarrat and Pacific Northwest bounty // We steam things up with a look at when – and why – to use a bamboo steamer // And of course, we’ll wrap up today’s show with Food for Thought: Tasty Trivia!

Pesto 28 AgostoSee omnystudio.com/listener for privacy information.

Bongani Bingwa speaks to founder of Pest Princess Foods, Kathleen Quillinan, about how a humble packet of soup from Pesto Princess Foods is stirring up more than just dinner, it’s fueling hope through their mission to reach R1 million in meals for South Africans in need. 702 Breakfast with Bongani Bingwa is broadcast on 702, a Johannesburg based talk radio station. Bongani makes sense of the news, interviews the key newsmakers of the day, and holds those in power to account on your behalf. The team bring you all you need to know to start your day Thank you for listening to a podcast from 702 Breakfast with Bongani Bingwa Listen live on Primedia+ weekdays from 06:00 and 09:00 (SA Time) to Breakfast with Bongani Bingwa broadcast on 702: https://buff.ly/gk3y0Kj For more from the show go to https://buff.ly/36edSLV or find all the catch-up podcasts here https://buff.ly/zEcM35T Subscribe to the 702 Daily and Weekly Newsletters https://buff.ly/v5mfetc Follow us on social media: 702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/Radio702 702 on YouTube: https://www.youtube.com/@radio702 See omnystudio.com/listener for privacy information.

Metz, Moritz www.deutschlandfunk.de, Verbrauchertipp

CNBC senior personal finance correspondent Sharon Epperson answers some of the biggest questions when it comes to Social Security. Also, George Oliphant, host of NBC's ‘George to the Rescue,' offers advice on the important home projects to take care of before summer ends. Plus, chef Anthony Vitolo shares three different ways to prepare pesto.

Kathleen Quillinan – Founder, Pesto Princess Foods SAfm Market Update - Podcasts and live stream

This evening, we dive into market movements with PSG Wealth Old Oak, we speak to BLSA about their newly launched tool designed to track the progress of government reforms, Merchant West discusses what's driving market volatility, we speak to Standard Bank CEO, Sim Tshabalala, on the group's latest results – and his decision to retire in the coming years, SAB shares insights on the role of women in the beer industry, and in this week's SME feature, we meet the founder of Pesto Princess – an opera singer turned entrepreneur. SAfm Market Update - Podcasts and live stream

Kelly Gibney joins us with a lovely mid week recipe. This week it's a pasta and we're including broccoli and spinach to add nutritional punch to the sauce. Adding lightly cooked broccoli and fresh baby spinach is an easy way to super-charge pesto. Recipe is here

Join hosts Asher and Kristen as they board the Culture Train and return to Riomaggiore in Cinque Terre, Italy! After visiting the colorful cliffside villages, today they head uphill to learn the true art of Ligurian pesto from Ms Barbara—right in her fragrant basil garden with panoramic views of the Mediterranean Sea. From basil grown in nearby Pra' to marble pestles and pine nuts, discover the traditions and flavors that make pesto à la Genovese so special. Fasten your imaginary aprons—we're making pesto the Ligurian way: buzzing basil gardens, marble mortars, and salt-sprinkled sea breezes. Discover ingredient secrets: sweet Pra'-grown basil, two-year-aged Parmigiano Reggiano, fresh Italian pine nuts, garlic, olive oil, and sea salt. Learn why using a cold marble mortar matters Cultural connections: hear how veggies, herbs, and cooking pass through generations, from Ms Barbara's grandmother to our family kitchens.

Join me for Day 3 of my Mosaic Foods review! Today I'm diving into Creamy Pesto Cavatappi and Spicy Dan Dan Noodles, taste-testing the full Mosaic Foods box. Is it worth your money? Watch my hands-on taste test to find out. #mosaicfoods #vegas #vegetarian #foodboxes #mealbox #tastetest Learn More About MosaicFoods Visit: https://mosaic-foods.sjv.io/2aedvQ Find As Seen On TV Products & Gadgets at the 9malls Store: https://www.amazon.com/shop/9malls Please support us on Patreon! https://www.patreon.com/9malls Disclaimer: I may also receive compensation if a visitor clicks through to 9malls, or makes a purchase through Amazon or any affiliate link. I test each product on site thoroughly and give high marks to only the best. In the above video I received a free product sample to test. We are independently owned and the opinions expressed here are our own.

Bylinky, domácí pesto, kuřecí roládky i oslavy svátků zpětně – Alenka a Jiřinka si u plotny i na balkoně mají co říct. Poslechněte si letní kuchařské rozpravy.

Send Bite Me a Text!Summer brings us one of nature's most under-appreciated treasures: garlic scapes. These curly green stems, once discarded as mere byproducts of garlic farming, now take center stage in this episode's featured recipe - a versatile, cannabis infused garlic scape pesto that perfectly captures summer's bounty.Whether you're new to cannabis cuisine or a seasoned chef, this garlic scape pesto offers endless possibilities for incorporating cannabis benefits into your meals in a controlled, intentional manner. Join me at the Bite Me Cannabis Club to connect with our supportive cannabis cooking community and share how you're using this versatile condiment in your kitchen!Stop lurking and start connecting—head to JoinBiteMe.com right now. Find a private community of cannabis growers, makers and lovers who are just as obsessed or curious as you are.Support the show Visit the website for full show notes, free dosing calculator, recipes and more.

Fearless Restaurant Group's "Dining Out for the Dogs" Jamie Blackburn, who is the Director of Public Relations for Fearless Restaurants discussed the upcoming 8th annual "Dining Out for the Dogs" event at White Dog Cafe on August 4th. The event benefits Alpha Bravo Canine, a nonprofit organization which provides service dogs to veterans. The event will be held at suburban locations and will feature special menu items, including a popular hot dog flight, puppy kissing booths, and Tito's cocktail offerings. Blackburn emphasized the importance of reservations, especially for the VIP dog-friendly tables, and highlighted the opportunity for community members to volunteer as puppy raisers for the service dog program.Farina Pasta Bar Our host next sat down with husband and wife team Dan and Taylor Lee who own Farina Pasta Bar, located in Philadelphia.  Dan shared his journey in the culinary industry to starting his business, eventually meeting his wife and business partner. The couple now runs both a food truck and a brick-and-mortar restaurant, balancing their busy schedules while inspiring others with their delicious dishes.Dan and Amaris discussed the concept of a pasta restaurant, where customers can build their own pasta dishes by choosing sauces and shapes. Dan explained that they make fresh pasta in-store, offering four main shapes, and plan to expand to include flavored pastas in the future. They discussed the differences between American and Italian dining portions, with Dan noting that their restaurant aims for a casual, lunch-focused concept with reasonable portion sizes. Dan also discussed Farina's customizable menu options for private events, including pasta, sauces, and gelato, as well as their unique pasta salads. He explained that their Rittenhouse location at 132 South 17th Street offers both in-store dining and takeout, and they can be found online at farinaphl.com and on Instagram @farina.phl. Revolution BeesLastly, Steve Occiolini and Walter Talunas discussed their journey into creating Revolution Bees. Steve and Walt are both beekeepers, with Steve starting his process of beekeeping to enhance his garden's productivity, while Walt was drawn to the hobby after reading a blog about beekeeping. They both emphasized the importance of bees in pollinating crops, with Walt noting that honeybees are responsible for 30-60% of all crops. They have been successful beekeepers for over 20 years, with Walt now maintaining over 40 hives.Mead Production and Flavor ExperimentationAmaris and Walt discussed the process of creating mead, a honey-based alcoholic beverage along with a number of other products that their company creates.  After chatting about the process of what the honey goes through for the various products, Steve and Walt shared the history and process on mead-making, ending with where you can purchase their products and find them in person, including farmers markets, Renaissance fairs, and wine festivals. For more information and where to find them, please visit revolutionbees.com. 

Join us as we recap and chat about Bob's Burgers Season 8 Episode 16 Are You There Bob? It's Me, Birthday and Season 8 Episode 17 BoywatchDid you know the title "Are You There Bob? It's Me, Birthday" is a reference to the 1970 book by Judy Blume, Are You There God? It's Me, Margaret.Wiki page for the episode:Are You There Bob? It's Me, BirthdayBoywatchJoin our Book Club and get access to exclusive content on PatreonFollow us on InstagramFollow us on TiktokFollow us on Bluesky

Nadeem asked Chat GPT for a lesser-known thriller that he hadn't seen, but should. The robots did their thing and suggested the 2017 thriller, "Berlin Syndrome" for the next movie review. Mita and Nadeem give their (spoiler-free) reviews of "Materialists". 

Furry friends are the best, a jewelry updating, changing the wardrobe, removing things we don't need, more Stanley's please,  printing pics   Bad thoughts, franklin, secrets we keep, instant family, rotten legacy, love is blind Germany vs uk, the stolen girl, beach hunters, bun heads.   Should we eat gluten free, high protein voo doo fries, homemade sloppy joes, bacon and cheese wrap, black bean quesadilla, Cheesesteak casserole. Pesto breakfast taco.   Happy hump day stars

This week, Jane explains how we experience nature with all of our senses by sharing a favorite recipe made with fresh ingredients from her garden.

Beppe, a native Italian, started his journey in active travel over two decades ago and, with the help of his wife Heather, co-founded Tourissimo, one of the top adventure travel companies in Italy. With years of expertise designing cycling and adventure tours across all 20 regions of Italy, Beppe and Heather have the inside scoop on the most authentic and unforgettable experiences Italy has to offer.So grab your espresso (or a glass of vino Italiano), and let's explore Italy region by region!Northern Italy: Adventure, Culture, and Alpine BeautyLombardy (Lombardia)Running along the Swiss border, Lombardy is Italy's largest and wealthiest region—a land of striking contrasts and cultural riches. Home to nearly 10 million people, Lombardy contains 12 of Italy's largest cities: Milan, Bergamo, Brescia, Como, Mantua, Pavia, Cremona, Lecco, Lodi, Monza, Sondrio, and Varese. The region blends modern sophistication with old-world charm, from the fashion capital and bustling metropolis of Milan to the serene, postcard-perfect landscapes of Lake Como.Lombardy is dotted with some of Italy's most beloved lakes, including Lake Maggiore, Lake Como, Lake Garda, Lake Iseo, Lake Idro, and many more. Picturesque villages like Bellagio offer sun-drenched escapes along Lake Como's shores, while the medieval towns of Bergamo and Mantova enchant visitors with cobblestone streets, sweeping views, and centuries of history.Culinary lovers will be spoiled for choice with Lombardy's 60 Michelin-starred restaurants—3 with three stars, 6 with two stars, and 51 with one star. Be sure to savor the region's iconic Risotto alla Milanese, a creamy saffron-infused dish that's a local staple. Wine enthusiasts won't want to miss a glass of Franciacorta, Italy's sparkling answer to Champagne.November is a wonderful time to visit, with cooler temperatures and fewer tourists. It's also the perfect season to explore Lombardy's slice of the Alps, where charming mountain towns await nestled among the peaks. For an unforgettable adventure, consider attending the 2025 Winter Olympics, which will be held in Milan-Cortina d'Ampezzo!Tourissimo Tip– If you are flying into Milan, select the correct airport because Milan has two airports! For info, check out the following Tourissimo blog: https://www.tourissimo.travel/blog/avoid-this-common-travel-mistake-know-milans-two-airportsVenetoVeneto, the birthplace of Prosecco, Polenta, and the iconic Spritz, is a region rich in charm, culture, and culinary delights. Stretching from the Italian Riviera to the Venetian Pre-Alps and the stunning Dolomites, Veneto is home to both natural beauty and historic towns. Its capital, the enchanting floating city of Venice, is world-famous for its canals, gondolas, labyrinthine streets, and undeniable romance.Each of Venice's islands offers something special: admire the colorful houses of Burano, renowned for its lace-making traditions; visit Murano, celebrated for its centuries-old glassblowing artistry; and soak up the peaceful atmosphere of Torcello. Exploring these islands by vaporetto (water bus) offers a quieter, more authentic glimpse into Venetian life. Tourissimo Tip–For a few more suggestions, check out Tourissimo's blog on the Venetian Lagoon: https://www.tourissimo.travel/blog/our-favorite-destinations-in-the-venetian-lagoonBeyond Venice, Veneto boasts a treasure trove of picturesque towns. Verona, Padua, Vicenza, and Asolo each offer their own distinct history and beauty. Visit Castelfranco Veneto for a charming escape or head to Bardolino to enjoy a boat ride on Italy's largest lake, Lago di Garda. Stroll the waterfront in Castelletto sul Garda or circle the freshwater moat of Cittadella, a red-brick medieval town full of character.In the countryside, the hills of Prosecco promise stunning vineyard views, while the medieval town of Montagnana offers a taste of the past. Nature lovers can visit the volcanic Euganean Hills in Este, and cheese lovers shouldn't miss the small town of Asiago, home to one of Italy's most famous cheeses.Veneto's culinary scene shines with 34 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 29 with one star. Indulge in local specialties like Bigoli in Salsa, a hearty Venetian pasta with anchovy sauce, and toast with a glass of Prosecco, Grappa, or the regional favorite, the Select Spritz. And don't forget—Venetians love to celebrate, so let loose and join the party!Tourissimo Tips–Another fun suggestion is Veneto Marostica, the City of Chess, where they do a living chess match with hundreds of people dressed in medieval costumes every two years: https://www.tourissimo.travel/blog/marostica-the-city-of-chessPiedmont (Piemonte)Nestled at the foot of the Alps and bordered on three sides by the Mediterranean Sea, Piedmont is one of Italy's most underrated gems. With a diverse landscape that offers adventure and beauty year-round, this region is perfect for both winter skiing and summer hiking and biking, thanks to its stunning Alpine scenery.But Piedmont isn't just about breathtaking views—it's steeped in rich history and cultural significance. As the first capital of Italy, it boasts grand palaces, remarkable art, and sacred relics like the famed Shroud of Turin. The capital city of Turin is a vibrant hub, home to Europe's largest outdoor food market and the monthly Gran Balon flea market, a haven for vintage and antique lovers.Venture beyond the city and you'll discover a region bursting with charm and flavor. Tour the Langhe Hills, a paradise for vineyard visits, and sample Bagna Cauda, a warm anchovy and garlic dip beloved by locals. Wander the lakeside town of Stresa on Lake Maggiore, or stroll the cobbled streets of Neive, where views of rolling hills and storybook cottages create an unforgettable setting. In Asti, you can witness the September medieval horse races and visit the majestic Cattedrale di Santa Maria Assunta e San Gottardo. For a true fairy-tale escape, head to Macugnaga in the valley of Monte Rosa, a perfect base for both skiing and hiking. And just outside of Turin lies the hidden gem of Lake Orta, a peaceful retreat away from the crowds.Piedmont's culinary scene is just as spectacular. With 35 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 30 with one star—the region is a paradise for food lovers. Dine in Alba during white truffle season (September to January), and savor iconic regional dishes like Agnolotti del Plin and Coniglio Arrosto. Wine enthusiasts will be in heaven here—Piedmont is the land of Barolo, the "king of wines," and Barbaresco, two of Italy's most prestigious reds.Tourissimo Tips:Piedmont is home to the Slow Food movement: https://www.tourissimo.travel/blog/why-piedmont-is-renowned-for-its-slow-foodTourissimo Tip–Check out this blog for a guide to a day of eating in Turin: https://www.tourissimo.travel/blog/a-day-of-eating-in-turinTourissimo Tip–One of the Best Meals of Your Life will be at the Piazza Duomo in Alba!Emilia-RomagnaLocated in central Italy along the Adriatic coast, Emilia-Romagna is a vibrant and diverse region known for its perfect blend of “slow food” and “fast cars.” This area is considered both the culinary and automotive capital of Italy, offering rich traditions, warm hospitality, and unforgettable experiences.Food lovers will be in heaven here. Emilia-Romagna is the birthplace of iconic Italian delicacies such as Mortadella, Tortellini in Brodo, Parmigiano-Reggiano, Prosciutto di Parma, traditional Balsamic Vinegar, Lambrusco, and egg-based fresh pastas like lasagna, tortellini, and tagliatelle. A visit to Parma lets you savor authentic Parmigiano-Reggiano and world-class Prosciutto, as well as enjoy the elegant Teatro Regio opera house.The region also has a need for speed—it's home to legendary automotive brands like Ferrari, Lamborghini, and Maserati. For car enthusiasts, the Ferrari Museum in Modena is a must-see. Emilia-Romagna even has a dedicated cycling tourism office, and in summer 2023, it played host to several stages of the Tour de France, which began in nearby Florence.Beyond the food and cars, Emilia-Romagna offers a range of enchanting destinations. The capital city of Bologna is known for its Piazza Maggiore, the Two Towers, and the scenic Santuario Madonna di San Luca. In Ravenna, marvel at the dazzling, colorful mosaics and the historic San Vitale Basilica. Along the coast, vibrant seaside resorts like Cervia, Cesenatico, and Rimini create a lively, carnival-like party atmosphere from late May through September. For a more peaceful experience, explore the medieval gem of Brisighella, a lesser-known treasure full of charm.When it comes to fine dining, Emilia-Romagna doesn't disappoint. The region boasts 24 Michelin-starred restaurants, including one three-star, three two-star, and twenty one-star establishments. Visitors are often struck by the warmth and generosity of the locals—some of the most hospitable people in Italy—who express their love through exceptional food and outstanding service.Tourissimo Tips:Did you know that there is a whole other country within Emilia Romagna? https://www.tourissimo.travel/blog/san-marino-the-other-small-country-within-italyTourissimo Tip–Pietra di Bismantova was an inspiration for Dante: https://www.tourissimo.travel/blog/pietra-di-bismantova-the-inspiration-for-dantes-purgatoryTourissimo Tip–You can cross the Rubicon: https://www.tourissimo.travel/blog/crossing-the-rubiconTrentino-South TyrolNestled along Italy's northern border with Switzerland, Trentino–South Tyrol is a stunning mountainous region that blends Italian and Austrian influences, making it a top destination for nature lovers and outdoor enthusiasts. With its striking Alpine scenery, exceptional cuisine, and rich cultural duality, this region offers the best of both worlds.The South Tyrol capital, Bolzano, is renowned for having the highest quality of life in Italy, combining the clean, efficient infrastructure often associated with Germany with the flavorful food and spirited lifestyle of Italian culture.Outdoor adventurers will be captivated by the Dolomites, with their dramatic limestone peaks—ideal for hiking, skiing, and breathtaking vistas. Don't miss the Alpe di Siusi, Europe's largest Alpine meadow, which is especially stunning in spring and summer. Explore shimmering Lake Garda and uncover the region's medieval past through spectacular castles like Schloss Tirol, Castel Roncolo, and Castel d'Appiano.Tourissimo Tip–An off-the-beaten-path outdoor paradise can be found in the Alps of Trentino. Check out the Val di Sole. This is one of the areas that Beppe and Heather regularly go to on their personal vacations in Italy: https://www.tourissimo.travel/blog/the-wild-dolomitesThe culinary offerings here reflect the region's unique blend of cultures. Traditional dishes range from Bratwurst and Goulash to Italian-style pastas with hearty meats like deer. Foodies should try Speck, a savory smoked ham, perfectly paired with a glass of Gewürztraminer, a fragrant white wine native to the area. The region also produces excellent white wines and lighter reds that pair beautifully with its alpine cuisine.When it comes to fine dining, Trentino–South Tyrol excels with 33 Michelin-starred restaurants, including three three-star, five two-star, and twenty-five one-star establishments, making it one of Italy's most impressive gourmet regions.LiguriaLocated along Italy's rugged northwestern coastline, Liguria—also known as the Italian Riviera—boasts dramatic cliffs, colorful seaside villages, and incredible culinary traditions. The region is best known for the five picturesque villages of Cinque Terre, as well as the glamorous resort towns of Portofino and Santa Margherita Ligure.Tourissimo Tip– If you visit the Cinque Terre, don't forget to look up, and hike up away from the crowds to see the heroic vineyards: https://www.tourissimo.travel/blog/the-heroic-winemaking-of-the-cinque-terreBecause of the narrow, winding roads with steep drop-offs, many travelers prefer to explore the region via the local train or by public or private boat. If you're planning to hike the famous trails, be aware that entrance permits are now required due to landslides and overtourism.In the regional capital of Genoa, dive into maritime history, visit the iconic San Lorenzo Cathedral, and wander the city's old port area. Just outside Genoa, discover the secluded San Fruttuoso Abbey, accessible only by boat or footpath. In Vernazza, one of the Cinque Terre towns, visit the Doria Castle and the beautiful Santa Margherita Church.Liguria is also a celebrity hotspot, and its cuisine is just as impressive as its scenery. Known as the birthplace of pesto, the region is famous for Pesto alla Genovese, made with a special local basil. Be sure to try the region's olive oil, garlic, cheeses, and exceptional seafood, especially the anchovies. Other regional specialties include Focaccia di Recco, a cheese-filled flatbread, and lighter olive oils that perfectly complement Ligurian dishes.For fine dining, Liguria is home to seven Michelin-starred restaurants, all with one star, offering refined cuisine rooted in the region's coastal and agricultural traditions.Friuli-Venezia Giulia (Friuli)Tucked between Veneto, Austria, and Slovenia, Friuli-Venezia Giulia is a lesser-known gem that offers a unique blend of Alpine landscapes, rich cultural heritage, and coastal charm. The region features part of the Dolomites, ideal for hiking, skiing, and capturing breathtaking scenery.The capital, Trieste, is a refined port city with a fascinating blend of Italian, Austro-Hungarian, and Slavic influences. Don't miss the Miramare Castle, perched over the sea with stunning views. In Cividale del Friuli, stroll through cobbled streets and sample Frico, a savory, crispy dish made of cheese and potatoes, best enjoyed with a glass of Schioppettino, a bold red wine native to the region.For outdoor adventures and relaxation, spend a beach day at Lignano Sabbiadoro, camp in Sistiana, bike the trails around Grado, or explore the ancient Roman ruins in Aquileia, a UNESCO World Heritage Site. Be sure to visit the enormous Grotta Gigante (Giant Cave), stroll through Unity of Italy Square, and tour the Revoltella Museum for modern art.Friuli-Venezia Giulia is also home to seven Michelin-starred restaurants, including two two-star establishments and five one-star venues, reflecting the region's quiet but impressive culinary scene.Tourissimo Tip– A hotel that Heather and Beppe love in Cormons is La Subida. It's a unique, high-end, and rustic property nestled in nature that boasts a 1-Michelin star restaurant: https://www.tourissimo.travel/blog/hotels-we-love-la-subidaAosta ValleyNestled in the northwestern tip of Italy, where it borders Switzerland and France, the Aosta Valley is Italy's smallest and highest region—a true mountain paradise. This alpine jewel is renowned for its dramatic snowcapped peaks, storybook castles, and a unique blend of French and Italian culture, as both languages are spoken here.The region is home to Mont Blanc (Monte Bianco), Europe's highest peak, which straddles the borders of Italy, France, and Switzerland. While the summit lies on the French side, visitors on the Italian side can experience the Skyway Monte Bianco, a breathtaking cable car ride offering panoramic views of the Alps.Key landmarks include the striking Matterhorn, the impressive Fénis and Savoy Castles, and the Bard Fortress, one of the largest and most remarkable fortifications in the Alps. After a day in the mountains, relax in one of the region's thermal spas, and indulge in Fonduta, a rich, velvety cheese fondue perfect for chilly alpine evenings.Wine lovers should sample the region's distinctive red mountain wines, especially Enfer d'Arvier, known for its bold flavor and high-altitude character.Tourissimo Tip–A fun tradition is the Friendship Cup, a communal cup of coffee: https://www.tourissimo.travel/blog/the-friendship-cup-of-valle-daostaCentral Italy: History, Art, and Rolling HillsTuscany (Toscana)Tuscany, the heart of the Renaissance, is a captivating region of rolling hills, cypress-lined roads, vineyards, and timeless art and architecture. Located just below Italy's northern regions, it's a haven for art lovers, history buffs, and food and wine enthusiasts alike. From Chianti to Brunello di Montalcino, the region offers a wide variety of world-class wines.The regional capital, Florence, is one of Italy's most walkable and safe major cities, making it ideal for solo travelers. Admire its architectural wonders while sipping on Chianti Classico and indulging in a local favorite—Bistecca alla Fiorentina. Must-see landmarks in Florence include the Cathedral of Santa Maria del Fiore (Duomo), Ponte Vecchio, Palazzo Vecchio, the Uffizi Gallery, and the Galleria dell'Accademia, home to Michelangelo's David. For iconic views, head to Piazzale Michelangelo.Beyond Florence, explore the historic cities of Siena, Lucca, and San Gimignano, each offering its own charm. Don't miss the Leaning Tower of Pisa or the Siena Cathedral, and spend time in the picturesque public squares like Piazza del Campo, Piazza della Signoria, and Piazza del Duomo.For off-the-beaten-path adventures, discover medieval hilltop villages such as Sorano, or head to the Maremma coast for scenic beaches and bold wines. Tuscany also shines in its culinary excellence, boasting 41 Michelin-starred restaurants—including 1 three-star, 5 two-star, and 35 one-star establishments.Tourissimo Tip–3 places in Tuscany you didn't know existed: https://www.tourissimo.travel/blog/three-places-in-tuscany-you-did-not-know-existedUmbriaUmbria, often called the "Green Heart of Italy," is the country's only completely landlocked region, nestled between Tuscany, Lazio, and Le Marche. Though it lacks large cities, Umbria more than makes up for it with breathtaking natural beauty, medieval towns, and a rich culinary tradition.One of Umbria's most impressive sights is the Cascata delle Marmore (Marmore Falls)—the second tallest waterfall in Europe. Nature lovers and photographers alike will be amazed by its dramatic 165-meter drop. The region is also home to Assisi, the birthplace of St. Francis, one of Italy's most revered saints, and a major pilgrimage destination.Food lovers will delight in Umbria's hearty, earthy cuisine, featuring lentils, mushroom-based dishes, cured meats, and the prized black truffle (Tartufo Nero di Norcia). Pair these specialties with a glass of Sagrantino di Montefalco, a robust red wine unique to the region.Umbria's culinary excellence is further reflected in its four Michelin-starred restaurants: Casa Vissani, Vespasia, Ada, and Elementi. Each holds one Michelin star, offering refined takes on the region's rustic flavors.Tourissimo Tip–Norcia is definitely one of Italy's culinary gems: https://www.tourissimo.travel/blog/norcia-one-of-italys-culinary-gemsMarcheLocated in central Italy on the Adriatic side, Marche is a beautiful region with a population of 1 million people, known for its charming towns, rich history, and welcoming, hardworking culture. The region offers stunning destinations like Urbino and Ancona, along with pristine beaches such as Spiaggia della Due Sorelle, Parco Naturale Monte San Bartolo, Mezzavalle, and the Riviera del Conero, not to mention many picturesque nature reserves.Must-see landmarks include Castello di Gradara, Palazzo Ducale di Urbino, the Sanctuary of the Holy House of Loreto, Cattedrale di San Ciriaco, Tempio del Valadier, and the breathtaking underground Frasassi Caves. Marche's favorite cities and nearby towns also include Gubbio, Assisi, Perugia, Orvieto, and Cascia.For those drawn to religious history, highlights include the Papal Basilica of Saint Francis, the Sacred Convent of Saint Francis, Basilica di Santa Maria degli Angeli, and Basilica di Santa Chiara in Assisi, as well as the Basilica of Santa Rita da Cascia. History lovers should visit Rocca Paolina, Piazza IV Novembre, Fontana Maggiore, Piazza del Comune, and Grotta di Monte Cucco, while museums like Narni Sotterranea, the National Gallery, and Nobile Collegio del Cambio offer rich cultural experiences.This region is famous for its culinary tradition, especially its mastery of seafood, and is home to seven Michelin-starred restaurants — including Uliassi in Senigallia, proudly holding three Michelin stars, along with one two-star and five one-star establishments. No visit would be complete without tasting Olive all'Ascolana, fried stuffed olives that perfectly capture Marche's local flavor. All of this, combined with the region's natural beauty and warm, fun, and friendly locals, makes Marche a truly unforgettable destination in the heart of Italy.Tourissimo Tip–Ascoli Piceno, the town where the Ascoli olive is from, is beautiful, especially at night when it appears to glow: https://www.tourissimo.travel/blog/ascoli-piceno-the-italian-town-that-glows-at-nightLazioLazio, one of Italy's central regions, though often considered a southern region by Italians, is a place rich with history, iconic landmarks, and hidden gems. At its heart is the capital city of Rome, a destination overflowing with opportunities for exploration. Essential sites include the Colosseum, Trevi Fountain, Pantheon, Roman Forum, Spanish Steps, St. Peter's Basilica, the Sistine Chapel, and countless other remarkable attractions. No visit to Rome is complete without savoring its famous dishes, including Cacio e Pepe — a creamy cheese and pepper pasta — along with local favorites like Spaghetti alla Gricia, Pasta all'Amatriciana, and Pasta Carbonara, best enjoyed with a glass of crisp Frascati wine while taking in views of the Colosseum. Lazio as a whole has 107 two-star Michelin restaurants and 105 one-star restaurants. If you find yourself in the Trastevere neighborhood, there are many wonderful popular restaurants, including La Scaletta and Le Mani in Pasta.Another must-see is Vatican City, home to the Vatican and its world-renowned religious and artistic treasures. In December 2025, Rome will host the Jubilee, or Holy Year — a significant Catholic Church event focused on forgiveness, reconciliation, and spiritual renewal, held only once every 25 years and drawing pilgrims from across the globe.Beyond Rome, Lazio offers a beautiful coastline and peaceful countryside, perfect for travelers seeking quieter escapes. Among its hidden gems is Ostia Antica, an ancient Roman city that once served as the bustling port of Rome, located at the mouth of the Tiber River. With its blend of legendary landmarks, culinary traditions, religious significance, and off-the-beaten-path treasures, Lazio is a captivating region waiting to be explored.Tourissimo Tip–There's a wonderful project underway to create a cycle path around the perimeter of Rome: https://www.tourissimo.travel/blog/cycling-in-rome-grab-a-bike-and-bike-the-grabAbruzzoAbruzzo, known as Italy's green region, lies in the central-eastern part of the country and boasts a stunning combination of mountains, coastline, and unspoiled nature. Along the beautiful Trabocchi Coast, visitors can admire the historic trabocchi — ingenious wooden fishing structures built by fishermen centuries ago to safely fish the Adriatic waters, many of which have now been converted into charming seaside restaurants where you can dine on fresh seafood while suspended above the waves with sunsets as your backdrop. When it comes to dining, Abruzzo currently boasts four Michelin-starred restaurants; there are three 1-star restaurants and one 3-star restaurant. Food lovers shouldn't miss Arrosticini, the region's famous grilled lamb skewers, or a glass of bold Montepulciano d'Abruzzo red wine. Outdoor enthusiasts have countless opportunities for adventure, from swimming at the Stiffe Caves and strolling the Ponte del Mare to relaxing on the beaches of Riserva Naturale Guidata Punta Aderci and hiking to the iconic Rocca Calascio. Lakeside escapes await at Lago di Scanno and Lago di Barrea, while the towering Gran Sasso d'Italia and the expansive Parco Nazionale d'Abruzzo, and Lazio e Molise offer breathtaking scenery and pristine trails. The region is home to many national parks — Abruzzo, Lazio, Molise National Park, Gran Sasso and Laga Mountains National Park, and Maiella National Park — perfect for hiking, biking, trail running, and spotting the highest peaks of the Apennine Mountain Range. Cyclists can enjoy the Bike to Coast cycle path, a 131 km (81.4 mile) route running along the Adriatic coast from Pescara to Vasto. History and architecture lovers will appreciate sites like Basilica di Santa Maria di Collemaggio, Centro Storico di Sulmona, Santo Stefano di Sessanio, Abbey of San Giovanni in Venere, and the Medieval Village of Pacentro. For a uniquely tranquil experience, visit the enchanting Gardens of Ninfa. Abruzzo is also a fabulous winter skiing destination and keeps traditions alive with events like Transumanza, the seasonal migration of livestock, primarily sheep, between the high-altitude pastures of the region. With its mountain majesty, historic villages, flavorful cuisine, and coastal charm, Abruzzo offers something unforgettable for every traveler.Tourissimo Tips:More info on the trabocchi coast: https://www.tourissimo.travel/blog/abruzzos-trabocchi-coastAbruzzo Bike to Coast is a beautiful bike path along the coast: https://www.tourissimo.travel/blog/cycling-along-abruzzos-coastMoliseOne of Italy's most untouched and lesser-known regions, Molise is famously nicknamed “the region that doesn't exist,” though it's rich in history, traditions, and natural beauty. This quiet region offers a mix of beaches and mountains, including part of the National Park of Abruzzo within the Apennines mountain range, filled with abundant wildlife, hiking trails, and winter ski opportunities. Tourissimo Tip–The Region That Doesn't Exist: https://www.tourissimo.travel/blog/the-italian-region-that-doesnt-existThe capital city, Campobasso, is home to notable sites like Monforte Castle and several Romanesque churches, while the charming coastal town of Termoli draws visitors for its beaches, trabucchi (historic fishing huts now serving fresh seafood), and local specialties like brodetto, a traditional seafood stew. Along the Molise coast in Termoli, dining at a trabucchi offers fresh catches with a side of Adriatic views. History buffs should visit the Samnite ruins in the Pietrabbondante archaeological area, the well-preserved Saepinum Archaeological Area, and landmarks like Lago di Castel San Vincenzo, the Cathedral of Saint Mary of the Purification, Monforte Castle, and the Basilica of Saint Mary of Sorrow. A must-see is the Marinelli Bell Foundry, founded in 1339. It's the oldest continuously operating bell foundry in the world, Italy's oldest family business, and the official provider of bells to the Vatican. Food lovers can sample Cavatelli, a local pasta specialty, paired with Tintilia, a rare red wine unique to Molise. The region is also home to seven one-star Michelin restaurants and several local food tours that showcase its rustic culinary traditions. While Molise's quiet charm and untouched landscapes make it a special destination, visitors should note that English is not widely spoken, making it a truly authentic Italian experience for those eager to explore one of the country's hidden gems.Southern Italy: Sun, Sea, and Ancient WondersCampania The birthplace of Neapolitan pizza, the Mediterranean Diet, and Mozzarella di Bufala, Campania is one of Italy's most vibrant and culturally rich regions. Home to the bustling regional capital Naples (Napoli), it boasts some of the country's most iconic destinations, including Pompeii, the stunning Amalfi Coast, and the tranquil Cilento Coast.Along the sparkling, deep-blue waters of the Golfo di Napoli, you'll find must-visit coastal towns like Positano, Amalfi, and Ravello, as well as the famous islands of Ischia, Capri, and the colorful Procida. Visitors can hike the breathtaking Path of the Gods, explore the hauntingly preserved ruins of Archaeological Pompeii, forever shadowed by the gray cone of Mt. Vesuvius, and savor the region's culinary gems like ultra-fresh seafood and crisp Falanghina wine.History and culture lovers shouldn't miss Sansevero Chapel Museum, San Carlo Theatre, the Catacombs of San Gennaro, and the lush Villa Cimbrone Gardens. Campania also impresses with its historic castles, including the Royal Palace of Caserta, Ovo Castle, and Castello Aragonese d'Ischia. Wine enthusiasts should head to the province of Avellino, known for producing some of the best wines in southern Italy.Tourissimo Tip–Wine is also grown inland on the Amalfi Coast, and there are some vines that are 250 years old (pre-phylloxera): https://www.tourissimo.travel/blog/old-vines-on-the-amalfi-coastNature lovers will be drawn to the Cilento, Vallo di Diano, and Alburni National Park, a UNESCO World Heritage Site celebrated for its biodiversity, dramatic landscapes, and cultural heritage, featuring ancient ruins like Paestum and Velia, the majestic Padula Charterhouse, and idyllic coastal villages.Campania is also a paradise for food lovers, home to 51 Michelin-starred restaurants, including one three-star, eight two-star, and forty-two one-star establishments. From world-famous landmarks to hidden treasures, Campania offers an irresistible blend of history, nature, food, and coastal charm.CalabriaWith its rugged coastlines, dramatic landscapes, and hidden treasures, Calabria is a must-visit region in southern Italy. Known for its bold flavors and rich culinary traditions, visitors should sample 'Nduja, a spicy, spreadable sausage paste, and the region's famous Calabrian chiles. The local cuisine embraces cucina povera, a tradition of simple, hearty dishes featuring handmade pasta made with just flour and water. Calabria offers a growing fine dining scene with six one-star Michelin restaurants. For nature lovers, Calabria is home to three stunning national parks — Sila, Aspromonte, and Pollino — ideal for hiking, wildlife spotting, and immersing in untouched landscapes. Along the coast, Capo Vaticano stands out as one of the world's most beautiful beaches, offering breathtaking views and crystal-clear waters. History buffs and castle enthusiasts can explore impressive fortresses like Castello Ruffo di Scilla, Castello Murat, Castello di Le Castella, and Castello Aragonese. Don't miss charming towns and villages such as Tropea, famous for its clifftop views and beaches, as well as Scilla, Pentedattilo, and Le Castella. With its authentic culture, stunning coastlines, flavorful cuisine, and rich history, Calabria remains one of Italy's most captivating yet underrated regions.Tourissimo Tip–Way off the beaten path, lies a  unique museum in Mammola, Calabria https://calabriastraordinaria.it/en/news/visit-to-musaba-the-sistine-chapel-of-calabriaPugliaKnown as the Maldives of Italy, Puglia is a sun-drenched region celebrated for its whitewashed hill towns, ancient olive groves, and miles of stunning coastline. With a dry Mediterranean climate and scenery that often feels more Greek than Italian, Puglia is famed for its beaches in Salento, crystal-clear waters, and charming seaside towns. One of its most iconic sights is the fairytale-like trulli houses of Alberobello, a UNESCO World Heritage Site. This region is also a food lover's paradise, offering specialties like Orecchiette pasta with turnip greens, the classic Fave e Cicoria (fava bean purée with wild chicory), and fresh seafood paired with crisp vegetables. Wine lovers can savor Primitivo, a bold local red. For fine dining, the region boasts nine one-star Michelin restaurants, blending rustic flavors with refined culinary creativity.Puglia is dotted with unique cities and towns worth exploring, including Locorotondo, Otranto, Lecce, Monopoli, Ostuni, Gallipoli, Bari, Alberobello, and Polignano a Mare. Nature and history enthusiasts will enjoy visiting extraordinary sites like the Grotte di Castellana, the dramatic Cave of Poetry, the ancient Basilica San Nicola, and the scenic Gargano Peninsula. With its thousand-year-old olive trees, Puglia is the largest olive oil producer in the world, known for its strong, spicy oils. The locals here are famously warm and welcoming, going out of their way to make visitors feel at home.Puglia's blend of natural beauty, rich tradition, and heartfelt hospitality makes it one of Italy's most captivating and underrated destinations.Tourissimo Tip–Here are some of the gems of Puglia: https://www.tourissimo.travel/blog/some-of-the-gems-of-pugliaBasilicataBasilicata, a remote yet captivating region with a population of just 500,000, offers a wealth of unique experiences despite its secluded location. Among its most intriguing destinations are the ghost town of Craco and the ancient cave city of Matera, both steeped in history and cinematic charm. Other towns worth visiting include Maratea and Palombaroa, each offering its own cultural and scenic appeal.Tourissimo Tip–Matera is magical! https://www.tourissimo.travel/blog/destination-highlight-matera-the-city-of-stonesThe region is rich in historical and religious landmarks, such as the Crypt of Original Sin with its remarkable frescoes, and the medieval Melfi Castle. Don't miss the towering Statue of Christ the Redeemer in Maratea, a striking monument that overlooks the Tyrrhenian coast.For a taste of local flavor, try Peperoni Cruschi—crispy, sun-dried peppers that are a beloved regional delicacy. Basilicata is also known for its exceptional wines, especially the bold, full-bodied reds of Aglianico del Vulture DOC, made primarily from the Aglianico grape. White wine lovers will appreciate the region's Greco di Tufo and Fiano varietals as well. Basilicata also has a total of 14 one-star Michelin restaurants. Adventurers can experience an adrenaline rush on The Angel's Flight, a giant zip line that offers stunning views and a thrilling ride through the Lucanian landscape.SicilySicily, the largest island in the Mediterranean Sea, is a world of its own, offering a diverse landscape of coastlines, mountains, and magical towns such as Cefalù, Palermo, Taormina, Catania, Noto, Agrigento, and Syracuse. Palermo serves as the cultural and diplomatic capital of the region, while Catania stands as its business hub.A volcanic island and UNESCO World Heritage Site, Sicily boasts a rich collection of cultural and natural treasures. Highlights include the awe-inspiring Valley of the Temples, the active volcano Mount Etna, the stunning Duomo di Cefalù, and the picturesque islands of Stromboli, Bella, and Ortigia. The region is also home to the renowned Baroque Triangle in the Val di Noto region of southeastern Sicily, where the eight towns of Caltagirone, Militello Val di Catania, Catania, Modica, Noto, Palazzolo Acreide, Ragusa, and Scicli have been recognized by UNESCO for their outstanding examples of late Baroque architecture.Sicily's culinary scene is just as impressive. Indulge in traditional Sicilian cannoli, filled with sheep's milk ricotta cheese and always stuffed fresh to order. Take a street food tour to savor local favorites like arancini, and don't miss sipping on a glass of Nero d'Avola, one of Sicily's most famous wines. The region is also internationally celebrated for its top-tier agriculture and winemaking.For a taste of authentic Italian charm beyond the tourist trail, explore the towns featured in I Borghi Più Belli d'Italia—Italy's list of its most beautiful hidden gems. Tourissimo Tip–This is a great tip for all 20 regions of Italy. Find out more here: https://www.tourissimo.travel/blog/the-most-beautiful-small-towns-in-italyFood lovers will be delighted to know that Sicily is also home to 23 Michelin-starred restaurants, including three two-star establishments and twenty with one star.Tourissimo Tip–If you visit Corleone, you should definitely learn about the legacy of the Mafia. We in North America tend to have a romanticized view of the mafia, but for the locals, the history is more brutal. See some photos and learn more here: https://www.tourissimo.travel/blog/letizia-battaglia-groundbreaking-photojournalist-who-fearlessly-documented-the-mafia-in-her-native-sicilySardiniaSardinia, the second-largest island in the Mediterranean after Sicily, is a rugged, rural paradise known for its natural beauty, deep-rooted traditions, and ancient history. The island is home to features like the Apennine Coast, the Adriatic Coast, and the Apennine Mountains. Most of Sardinia's population lives in the capital region of Cagliari, but much of the island remains untouched, offering visitors a glimpse into authentic Italian island life.One of Sardinia's most fascinating distinctions is that the Barbagia region is recognized as a Blue Zone—an area with an unusually high number of centenarians. This longevity is attributed to the region's healthy diet, active lifestyle, and strong sense of community. For outdoor enthusiasts, inland Sardinia offers some of the best biking and hiking experiences in all of Italy.Tourissimo Tip–What is a Blue Zone? https://www.tourissimo.travel/blog/blue-zoneThe island's coastlines are just as enticing. Costa Smeralda is often described as paradise on earth, with stunning beaches like Spiaggia di Tuerredda, Cala Goloritzé, and Spiaggia di Porto Giunco perfect for sunbathing and swimming. Don't miss the La Maddalena Archipelago National Park (Parco Nazionale dell'Arcipelago di La Maddalena), a protected area with crystal-clear waters and pristine landscapes.Charming towns such as Alghero, Bosa, and Cagliari add to the island's appeal. Many of Sardinia's towns are nestled in the mountains located in the island's center, offering a peaceful and scenic escape.Cultural and historical attractions abound. Must-see sites include the Nora Archaeological Park, Bastione di Saint Remy, Parco Archeologico Naturalistico di Santa Cristina, and the Museo Archeologico Nazionale di Cagliari. For an unforgettable natural wonder, venture into the Frecce delle grotte srl and Neptune's Grotto, stunning sea caves accessible by boat or stairs carved into cliffs.Sardinia is also home to a unique ancient civilization. Scattered across the island are over 7,000 nuraghe—megalithic stone structures built during the Nuragic Age (c. 1900–730 BC). These mysterious, tower-like buildings are the island's most iconic symbol, and some scholars believe there were once over 10,000 nuraghe structures in total.Religious architecture also impresses, with highlights like the Cattedrale di Santa Maria Assunta e Santa Cecilia, the Church of the Holy Trinity of Saccargia, and the Basilica di San Simplicio showcasing Sardinia's spiritual and artistic heritage.Sardinian cuisine reflects its mountainous geography. Surprisingly, for an island, the diet leans more toward land-based ingredients than seafood. Signature dishes include Porceddu (roast pig), Fregola (a traditional Sardinian pasta), and the adventurous Casu marzu—a sheep's milk cheese intentionally infested with live maggots and considered a local delicacy. Sardinia also holds 16 one-star Michelin restaurants.To accompany these flavors, try a glass of Cannonau red wine, known for its high polyphenol content and potential health benefits, or the refreshing Vermentino white wine, perfect for warm Mediterranean days.Tourissimo Tip–Magic Trick or Pasta Making? https://www.tourissimo.travel/blog/magic-trick-or-pasta-making From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio!From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio! 

Grand innovateur et champion de la diversification, le numéro un mondial des pâtes italiennes fait un carton en France avec ses sauces, notamment le pesto. Dans « La Story », le podcast d'actualité des « Echos », Pierrick Fay et ses invitées dévoilent les clés du succès de Barilla.Retrouvez l'essentiel de l'actualité économique grâce à notre offre d'abonnement Access : abonnement.lesechos.fr/lastory« La Story » est un podcast des « Echos » présenté par Pierrick Fay. Cet épisode a été enregistré en avril 2025. Rédaction en chef : Clémence Lemaistre. Invitées : Florence Bauchard (journaliste aux « Echos Week-end ») et Dominique Chapuis (journaliste spécialiste de l'agroalimentaire aux « Echos »). Réalisation : Willy Ganne et Nicolas Jean. Chargée de production et d'édition : Michèle Warnet. Musique : Théo Boulenger. Identité graphique : Upian. Photo : Andrey Rudakov/Bloomberg. Sons : « Les bronzés font du ski » (1979), M6 +, Barilla, « L'aventure c'est l'aventure » (1972), Le Muppet Show, Harrys. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this lost episode Johnny Mack shares five uplifting tales. Highlights include Pesto the oversized penguin at Sea Life Melbourne, a new origami-based test for detecting infectious diseases, a finger-counting method improving children's math skills, the approval of a nasal spray flu vaccine by the FDA, and David Rush reclaiming his chopstick-throwing world record. Despite being older stories, they bring joy and positivity.00:00 Introduction to The Lost Five Good News Stories00:36 Pesto the Penguin: The Viral King02:09 Innovative Origami Paper Sensors for Disease Detection02:38 Finger Counting Method Boosts Math Skills in Children03:22 FDA Approves Nasal Spray Flu Vaccine03:43 Record-Breaking Chopstick Thrower Unlock an ad-free podcast experience with Caloroga Shark Media! Get all our shows on any player you love, hassle free! For Apple users, hit the banner on your Apple podcasts app which seays UNINTERRUPTED LISTENING. For Spotify or other players, visit caloroga.com/plus. No plug-ins needed!  You also get 20+ other shows on the network ad-free!   

"My mouth is on fire. My tongue is totally burned, but I want another one… 'cause it's so good."This episode was such a wild mix of adventure, confusion, and food. It's one of those travel days where you don't really know what's going to happen next, and I loved every second of it.From riding a half-broken bike through the hills of Northern Thailand to accidentally sitting in duck poo and stumbling upon a garden full of phallic statues, this day had it all. Pai totally surprised me—it was way more lively and international than I expected, and the street food scene was on another level.This episode is all about leaning into the chaos of travel, trying weird and wonderful things, and laughing along the way.Key Talking Points:The wild road trip from Chiang Mai to Pai – 762 turns and a lemon of a bike.The Erotic Garden – a totally unexpected and hilarious stop filled with art, innuendo, and surprise wisdom.Hopping on a bike - Riding experience in Thailand was different from that of VietnamEating everything – from gyoza and halal dumplings to coconut pancakes, and even lasagna made with macaroni.First impressions of Pai – hippie vibes, Gen Z fashion, TikTok-famous “banh mi,” and a whole lot of fun.Chapters and Timestamps01:30 – First stop: a totally unexpected Erotic Garden06:00 – Waterfalls, steep hills, and a near-death motorbike experience17:30 – Finally in Pai: weird fashion, hippie energy, and international food22:00 – The wild night market: Gen Z, food, and weed shops26:00 – More food: stuffed peppers, halal dumplings, and fake banh mi32:00 – A lasagna bar in Thailand (yes, really)34:30 – Pesto's not the best, but the spinach-mac combo hits the spot"Send me a message!"7 Bridges Brewing Co. - An award winning Vietnamese craft brewery from Da Nang, with breweries across Vietnam!Rabbit Hole Irish Sports Bar - Check out their new location on Tran Nao with the best views in the city over Landmark 81!Support the show

Connect:Email the show at bobsburgersreheated@gmail.comFollow the show @bobsburgersreheated on Instagram

Beppe, a native Italian, started his journey in active travel over two decades ago and, with the help of his wife Heather, co-founded Tourissimo, one of the top adventure travel companies in Italy. With years of expertise designing cycling and adventure tours across all 20 regions of Italy, Beppe and Heather have the inside scoop on the most authentic and unforgettable experiences Italy has to offer.So grab your espresso (or a glass of vino Italiano), and let's explore Italy region by region!Northern Italy: Adventure, Culture, and Alpine BeautyLombardy (Lombardia)Running along the Swiss border, Lombardy is Italy's largest and wealthiest region—a land of striking contrasts and cultural riches. Home to nearly 10 million people, Lombardy contains 12 of Italy's largest cities: Milan, Bergamo, Brescia, Como, Mantua, Pavia, Cremona, Lecco, Lodi, Monza, Sondrio, and Varese. The region blends modern sophistication with old-world charm, from the fashion capital and bustling metropolis of Milan to the serene, postcard-perfect landscapes of Lake Como.Lombardy is dotted with some of Italy's most beloved lakes, including Lake Maggiore, Lake Como, Lake Garda, Lake Iseo, Lake Idro, and many more. Picturesque villages like Bellagio offer sun-drenched escapes along Lake Como's shores, while the medieval towns of Bergamo and Mantova enchant visitors with cobblestone streets, sweeping views, and centuries of history.Culinary lovers will be spoiled for choice with Lombardy's 60 Michelin-starred restaurants—3 with three stars, 6 with two stars, and 51 with one star. Be sure to savor the region's iconic Risotto alla Milanese, a creamy saffron-infused dish that's a local staple. Wine enthusiasts won't want to miss a glass of Franciacorta, Italy's sparkling answer to Champagne.November is a wonderful time to visit, with cooler temperatures and fewer tourists. It's also the perfect season to explore Lombardy's slice of the Alps, where charming mountain towns await nestled among the peaks. For an unforgettable adventure, consider attending the 2025 Winter Olympics, which will be held in Milan-Cortina d'Ampezzo!Tourissimo Tip– If you are flying into Milan, select the correct airport because Milan has two airports! For info, check out the following Tourissimo blog: https://www.tourissimo.travel/blog/avoid-this-common-travel-mistake-know-milans-two-airportsVenetoVeneto, the birthplace of Prosecco, Polenta, and the iconic Spritz, is a region rich in charm, culture, and culinary delights. Stretching from the Italian Riviera to the Venetian Pre-Alps and the stunning Dolomites, Veneto is home to both natural beauty and historic towns. Its capital, the enchanting floating city of Venice, is world-famous for its canals, gondolas, labyrinthine streets, and undeniable romance.Each of Venice's islands offers something special: admire the colorful houses of Burano, renowned for its lace-making traditions; visit Murano, celebrated for its centuries-old glassblowing artistry; and soak up the peaceful atmosphere of Torcello. Exploring these islands by vaporetto (water bus) offers a quieter, more authentic glimpse into Venetian life. Tourissimo Tip–For a few more suggestions, check out Tourissimo's blog on the Venetian Lagoon: https://www.tourissimo.travel/blog/our-favorite-destinations-in-the-venetian-lagoonBeyond Venice, Veneto boasts a treasure trove of picturesque towns. Verona, Padua, Vicenza, and Asolo each offer their own distinct history and beauty. Visit Castelfranco Veneto for a charming escape or head to Bardolino to enjoy a boat ride on Italy's largest lake, Lago di Garda. Stroll the waterfront in Castelletto sul Garda or circle the freshwater moat of Cittadella, a red-brick medieval town full of character.In the countryside, the hills of Prosecco promise stunning vineyard views, while the medieval town of Montagnana offers a taste of the past. Nature lovers can visit the volcanic Euganean Hills in Este, and cheese lovers shouldn't miss the small town of Asiago, home to one of Italy's most famous cheeses.Veneto's culinary scene shines with 34 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 29 with one star. Indulge in local specialties like Bigoli in Salsa, a hearty Venetian pasta with anchovy sauce, and toast with a glass of Prosecco, Grappa, or the regional favorite, the Select Spritz. And don't forget—Venetians love to celebrate, so let loose and join the party!Tourissimo Tips–Another fun suggestion is Veneto Marostica, the City of Chess, where they do a living chess match with hundreds of people dressed in medieval costumes every two years: https://www.tourissimo.travel/blog/marostica-the-city-of-chessPiedmont (Piemonte)Nestled at the foot of the Alps and bordered on three sides by the Mediterranean Sea, Piedmont is one of Italy's most underrated gems. With a diverse landscape that offers adventure and beauty year-round, this region is perfect for both winter skiing and summer hiking and biking, thanks to its stunning Alpine scenery.But Piedmont isn't just about breathtaking views—it's steeped in rich history and cultural significance. As the first capital of Italy, it boasts grand palaces, remarkable art, and sacred relics like the famed Shroud of Turin. The capital city of Turin is a vibrant hub, home to Europe's largest outdoor food market and the monthly Gran Balon flea market, a haven for vintage and antique lovers.Venture beyond the city and you'll discover a region bursting with charm and flavor. Tour the Langhe Hills, a paradise for vineyard visits, and sample Bagna Cauda, a warm anchovy and garlic dip beloved by locals. Wander the lakeside town of Stresa on Lake Maggiore, or stroll the cobbled streets of Neive, where views of rolling hills and storybook cottages create an unforgettable setting. In Asti, you can witness the September medieval horse races and visit the majestic Cattedrale di Santa Maria Assunta e San Gottardo. For a true fairy-tale escape, head to Macugnaga in the valley of Monte Rosa, a perfect base for both skiing and hiking. And just outside of Turin lies the hidden gem of Lake Orta, a peaceful retreat away from the crowds.Piedmont's culinary scene is just as spectacular. With 35 Michelin-starred restaurants—2 with three stars, 3 with two stars, and 30 with one star—the region is a paradise for food lovers. Dine in Alba during white truffle season (September to January), and savor iconic regional dishes like Agnolotti del Plin and Coniglio Arrosto. Wine enthusiasts will be in heaven here—Piedmont is the land of Barolo, the "king of wines," and Barbaresco, two of Italy's most prestigious reds.Tourissimo Tips:Piedmont is home to the Slow Food movement: https://www.tourissimo.travel/blog/why-piedmont-is-renowned-for-its-slow-foodTourissimo Tip–Check out this blog for a guide to a day of eating in Turin: https://www.tourissimo.travel/blog/a-day-of-eating-in-turinTourissimo Tip–One of the Best Meals of Your Life will be at the Piazza Duomo in Alba!Emilia-RomagnaLocated in central Italy along the Adriatic coast, Emilia-Romagna is a vibrant and diverse region known for its perfect blend of “slow food” and “fast cars.” This area is considered both the culinary and automotive capital of Italy, offering rich traditions, warm hospitality, and unforgettable experiences.Food lovers will be in heaven here. Emilia-Romagna is the birthplace of iconic Italian delicacies such as Mortadella, Tortellini in Brodo, Parmigiano-Reggiano, Prosciutto di Parma, traditional Balsamic Vinegar, Lambrusco, and egg-based fresh pastas like lasagna, tortellini, and tagliatelle. A visit to Parma lets you savor authentic Parmigiano-Reggiano and world-class Prosciutto, as well as enjoy the elegant Teatro Regio opera house.The region also has a need for speed—it's home to legendary automotive brands like Ferrari, Lamborghini, and Maserati. For car enthusiasts, the Ferrari Museum in Modena is a must-see. Emilia-Romagna even has a dedicated cycling tourism office, and in summer 2023, it played host to several stages of the Tour de France, which began in nearby Florence.Beyond the food and cars, Emilia-Romagna offers a range of enchanting destinations. The capital city of Bologna is known for its Piazza Maggiore, the Two Towers, and the scenic Santuario Madonna di San Luca. In Ravenna, marvel at the dazzling, colorful mosaics and the historic San Vitale Basilica. Along the coast, vibrant seaside resorts like Cervia, Cesenatico, and Rimini create a lively, carnival-like party atmosphere from late May through September. For a more peaceful experience, explore the medieval gem of Brisighella, a lesser-known treasure full of charm.When it comes to fine dining, Emilia-Romagna doesn't disappoint. The region boasts 24 Michelin-starred restaurants, including one three-star, three two-star, and twenty one-star establishments. Visitors are often struck by the warmth and generosity of the locals—some of the most hospitable people in Italy—who express their love through exceptional food and outstanding service.Tourissimo Tips:Did you know that there is a whole other country within Emilia Romagna? https://www.tourissimo.travel/blog/san-marino-the-other-small-country-within-italyTourissimo Tip–Pietra di Bismantova was an inspiration for Dante: https://www.tourissimo.travel/blog/pietra-di-bismantova-the-inspiration-for-dantes-purgatoryTourissimo Tip–You can cross the Rubicon: https://www.tourissimo.travel/blog/crossing-the-rubiconTrentino-South TyrolNestled along Italy's northern border with Switzerland, Trentino–South Tyrol is a stunning mountainous region that blends Italian and Austrian influences, making it a top destination for nature lovers and outdoor enthusiasts. With its striking Alpine scenery, exceptional cuisine, and rich cultural duality, this region offers the best of both worlds.The South Tyrol capital, Bolzano, is renowned for having the highest quality of life in Italy, combining the clean, efficient infrastructure often associated with Germany with the flavorful food and spirited lifestyle of Italian culture.Outdoor adventurers will be captivated by the Dolomites, with their dramatic limestone peaks—ideal for hiking, skiing, and breathtaking vistas. Don't miss the Alpe di Siusi, Europe's largest Alpine meadow, which is especially stunning in spring and summer. Explore shimmering Lake Garda and uncover the region's medieval past through spectacular castles like Schloss Tirol, Castel Roncolo, and Castel d'Appiano.Tourissimo Tip–An off-the-beaten-path outdoor paradise can be found in the Alps of Trentino. Check out the Val di Sole. This is one of the areas that Beppe and Heather regularly go to on their personal vacations in Italy: https://www.tourissimo.travel/blog/the-wild-dolomitesThe culinary offerings here reflect the region's unique blend of cultures. Traditional dishes range from Bratwurst and Goulash to Italian-style pastas with hearty meats like deer. Foodies should try Speck, a savory smoked ham, perfectly paired with a glass of Gewürztraminer, a fragrant white wine native to the area. The region also produces excellent white wines and lighter reds that pair beautifully with its alpine cuisine.When it comes to fine dining, Trentino–South Tyrol excels with 33 Michelin-starred restaurants, including three three-star, five two-star, and twenty-five one-star establishments, making it one of Italy's most impressive gourmet regions.LiguriaLocated along Italy's rugged northwestern coastline, Liguria—also known as the Italian Riviera—boasts dramatic cliffs, colorful seaside villages, and incredible culinary traditions. The region is best known for the five picturesque villages of Cinque Terre, as well as the glamorous resort towns of Portofino and Santa Margherita Ligure.Tourissimo Tip– If you visit the Cinque Terre, don't forget to look up, and hike up away from the crowds to see the heroic vineyards: https://www.tourissimo.travel/blog/the-heroic-winemaking-of-the-cinque-terreBecause of the narrow, winding roads with steep drop-offs, many travelers prefer to explore the region via the local train or by public or private boat. If you're planning to hike the famous trails, be aware that entrance permits are now required due to landslides and overtourism.In the regional capital of Genoa, dive into maritime history, visit the iconic San Lorenzo Cathedral, and wander the city's old port area. Just outside Genoa, discover the secluded San Fruttuoso Abbey, accessible only by boat or footpath. In Vernazza, one of the Cinque Terre towns, visit the Doria Castle and the beautiful Santa Margherita Church.Liguria is also a celebrity hotspot, and its cuisine is just as impressive as its scenery. Known as the birthplace of pesto, the region is famous for Pesto alla Genovese, made with a special local basil. Be sure to try the region's olive oil, garlic, cheeses, and exceptional seafood, especially the anchovies. Other regional specialties include Focaccia di Recco, a cheese-filled flatbread, and lighter olive oils that perfectly complement Ligurian dishes.For fine dining, Liguria is home to seven Michelin-starred restaurants, all with one star, offering refined cuisine rooted in the region's coastal and agricultural traditions.Friuli-Venezia Giulia (Friuli)Tucked between Veneto, Austria, and Slovenia, Friuli-Venezia Giulia is a lesser-known gem that offers a unique blend of Alpine landscapes, rich cultural heritage, and coastal charm. The region features part of the Dolomites, ideal for hiking, skiing, and capturing breathtaking scenery.The capital, Trieste, is a refined port city with a fascinating blend of Italian, Austro-Hungarian, and Slavic influences. Don't miss the Miramare Castle, perched over the sea with stunning views. In Cividale del Friuli, stroll through cobbled streets and sample Frico, a savory, crispy dish made of cheese and potatoes, best enjoyed with a glass of Schioppettino, a bold red wine native to the region.For outdoor adventures and relaxation, spend a beach day at Lignano Sabbiadoro, camp in Sistiana, bike the trails around Grado, or explore the ancient Roman ruins in Aquileia, a UNESCO World Heritage Site. Be sure to visit the enormous Grotta Gigante (Giant Cave), stroll through Unity of Italy Square, and tour the Revoltella Museum for modern art.Friuli-Venezia Giulia is also home to seven Michelin-starred restaurants, including two two-star establishments and five one-star venues, reflecting the region's quiet but impressive culinary scene.Tourissimo Tip– A hotel that Heather and Beppe love in Cormons is La Subida. It's a unique, high-end, and rustic property nestled in nature that boasts a 1-Michelin star restaurant: https://www.tourissimo.travel/blog/hotels-we-love-la-subidaAosta ValleyNestled in the northwestern tip of Italy, where it borders Switzerland and France, the Aosta Valley is Italy's smallest and highest region—a true mountain paradise. This alpine jewel is renowned for its dramatic snowcapped peaks, storybook castles, and a unique blend of French and Italian culture, as both languages are spoken here.The region is home to Mont Blanc (Monte Bianco), Europe's highest peak, which straddles the borders of Italy, France, and Switzerland. While the summit lies on the French side, visitors on the Italian side can experience the Skyway Monte Bianco, a breathtaking cable car ride offering panoramic views of the Alps.Key landmarks include the striking Matterhorn, the impressive Fénis and Savoy Castles, and the Bard Fortress, one of the largest and most remarkable fortifications in the Alps. After a day in the mountains, relax in one of the region's thermal spas, and indulge in Fonduta, a rich, velvety cheese fondue perfect for chilly alpine evenings.Wine lovers should sample the region's distinctive red mountain wines, especially Enfer d'Arvier, known for its bold flavor and high-altitude character.Tourissimo Tip–A fun tradition is the Friendship Cup, a communal cup of coffee: https://www.tourissimo.travel/blog/the-friendship-cup-of-valle-daostaCentral Italy: History, Art, and Rolling HillsTuscany (Toscana)Tuscany, the heart of the Renaissance, is a captivating region of rolling hills, cypress-lined roads, vineyards, and timeless art and architecture. Located just below Italy's northern regions, it's a haven for art lovers, history buffs, and food and wine enthusiasts alike. From Chianti to Brunello di Montalcino, the region offers a wide variety of world-class wines.The regional capital, Florence, is one of Italy's most walkable and safe major cities, making it ideal for solo travelers. Admire its architectural wonders while sipping on Chianti Classico and indulging in a local favorite—Bistecca alla Fiorentina. Must-see landmarks in Florence include the Cathedral of Santa Maria del Fiore (Duomo), Ponte Vecchio, Palazzo Vecchio, the Uffizi Gallery, and the Galleria dell'Accademia, home to Michelangelo's David. For iconic views, head to Piazzale Michelangelo.Beyond Florence, explore the historic cities of Siena, Lucca, and San Gimignano, each offering its own charm. Don't miss the Leaning Tower of Pisa or the Siena Cathedral, and spend time in the picturesque public squares like Piazza del Campo, Piazza della Signoria, and Piazza del Duomo.For off-the-beaten-path adventures, discover medieval hilltop villages such as Sorano, or head to the Maremma coast for scenic beaches and bold wines. Tuscany also shines in its culinary excellence, boasting 41 Michelin-starred restaurants—including 1 three-star, 5 two-star, and 35 one-star establishments.Tourissimo Tip–3 places in Tuscany you didn't know existed: https://www.tourissimo.travel/blog/three-places-in-tuscany-you-did-not-know-existedUmbriaUmbria, often called the "Green Heart of Italy," is the country's only completely landlocked region, nestled between Tuscany, Lazio, and Le Marche. Though it lacks large cities, Umbria more than makes up for it with breathtaking natural beauty, medieval towns, and a rich culinary tradition.One of Umbria's most impressive sights is the Cascata delle Marmore (Marmore Falls)—the second tallest waterfall in Europe. Nature lovers and photographers alike will be amazed by its dramatic 165-meter drop. The region is also home to Assisi, the birthplace of St. Francis, one of Italy's most revered saints, and a major pilgrimage destination.Food lovers will delight in Umbria's hearty, earthy cuisine, featuring lentils, mushroom-based dishes, cured meats, and the prized black truffle (Tartufo Nero di Norcia). Pair these specialties with a glass of Sagrantino di Montefalco, a robust red wine unique to the region.Umbria's culinary excellence is further reflected in its four Michelin-starred restaurants: Casa Vissani, Vespasia, Ada, and Elementi. Each holds one Michelin star, offering refined takes on the region's rustic flavors.Tourissimo Tip–Norcia is definitely one of Italy's culinary gems: https://www.tourissimo.travel/blog/norcia-one-of-italys-culinary-gemsMarcheLocated in central Italy on the Adriatic side, Marche is a beautiful region with a population of 1 million people, known for its charming towns, rich history, and welcoming, hardworking culture. The region offers stunning destinations like Urbino and Ancona, along with pristine beaches such as Spiaggia della Due Sorelle, Parco Naturale Monte San Bartolo, Mezzavalle, and the Riviera del Conero, not to mention many picturesque nature reserves.Must-see landmarks include Castello di Gradara, Palazzo Ducale di Urbino, the Sanctuary of the Holy House of Loreto, Cattedrale di San Ciriaco, Tempio del Valadier, and the breathtaking underground Frasassi Caves. Marche's favorite cities and nearby towns also include Gubbio, Assisi, Perugia, Orvieto, and Cascia.For those drawn to religious history, highlights include the Papal Basilica of Saint Francis, the Sacred Convent of Saint Francis, Basilica di Santa Maria degli Angeli, and Basilica di Santa Chiara in Assisi, as well as the Basilica of Santa Rita da Cascia. History lovers should visit Rocca Paolina, Piazza IV Novembre, Fontana Maggiore, Piazza del Comune, and Grotta di Monte Cucco, while museums like Narni Sotterranea, the National Gallery, and Nobile Collegio del Cambio offer rich cultural experiences.This region is famous for its culinary tradition, especially its mastery of seafood, and is home to seven Michelin-starred restaurants — including Uliassi in Senigallia, proudly holding three Michelin stars, along with one two-star and five one-star establishments. No visit would be complete without tasting Olive all'Ascolana, fried stuffed olives that perfectly capture Marche's local flavor. All of this, combined with the region's natural beauty and warm, fun, and friendly locals, makes Marche a truly unforgettable destination in the heart of Italy.Tourissimo Tip–Ascoli Piceno, the town where the Ascoli olive is from, is beautiful, especially at night when it appears to glow: https://www.tourissimo.travel/blog/ascoli-piceno-the-italian-town-that-glows-at-nightLazioLazio, one of Italy's central regions, though often considered a southern region by Italians, is a place rich with history, iconic landmarks, and hidden gems. At its heart is the capital city of Rome, a destination overflowing with opportunities for exploration. Essential sites include the Colosseum, Trevi Fountain, Pantheon, Roman Forum, Spanish Steps, St. Peter's Basilica, the Sistine Chapel, and countless other remarkable attractions. No visit to Rome is complete without savoring its famous dishes, including Cacio e Pepe — a creamy cheese and pepper pasta — along with local favorites like Spaghetti alla Gricia, Pasta all'Amatriciana, and Pasta Carbonara, best enjoyed with a glass of crisp Frascati wine while taking in views of the Colosseum. Lazio as a whole has 107 two-star Michelin restaurants and 105 one-star restaurants. If you find yourself in the Trastevere neighborhood, there are many wonderful popular restaurants, including La Scaletta and Le Mani in Pasta.Another must-see is Vatican City, home to the Vatican and its world-renowned religious and artistic treasures. In December 2025, Rome will host the Jubilee, or Holy Year — a significant Catholic Church event focused on forgiveness, reconciliation, and spiritual renewal, held only once every 25 years and drawing pilgrims from across the globe.Beyond Rome, Lazio offers a beautiful coastline and peaceful countryside, perfect for travelers seeking quieter escapes. Among its hidden gems is Ostia Antica, an ancient Roman city that once served as the bustling port of Rome, located at the mouth of the Tiber River. With its blend of legendary landmarks, culinary traditions, religious significance, and off-the-beaten-path treasures, Lazio is a captivating region waiting to be explored.Tourissimo Tip–There's a wonderful project underway to create a cycle path around the perimeter of Rome: https://www.tourissimo.travel/blog/cycling-in-rome-grab-a-bike-and-bike-the-grabAbruzzoAbruzzo, known as Italy's green region, lies in the central-eastern part of the country and boasts a stunning combination of mountains, coastline, and unspoiled nature. Along the beautiful Trabocchi Coast, visitors can admire the historic trabocchi — ingenious wooden fishing structures built by fishermen centuries ago to safely fish the Adriatic waters, many of which have now been converted into charming seaside restaurants where you can dine on fresh seafood while suspended above the waves with sunsets as your backdrop. When it comes to dining, Abruzzo currently boasts four Michelin-starred restaurants; there are three 1-star restaurants and one 3-star restaurant. Food lovers shouldn't miss Arrosticini, the region's famous grilled lamb skewers, or a glass of bold Montepulciano d'Abruzzo red wine. Outdoor enthusiasts have countless opportunities for adventure, from swimming at the Stiffe Caves and strolling the Ponte del Mare to relaxing on the beaches of Riserva Naturale Guidata Punta Aderci and hiking to the iconic Rocca Calascio. Lakeside escapes await at Lago di Scanno and Lago di Barrea, while the towering Gran Sasso d'Italia and the expansive Parco Nazionale d'Abruzzo, and Lazio e Molise offer breathtaking scenery and pristine trails. The region is home to many national parks — Abruzzo, Lazio, Molise National Park, Gran Sasso and Laga Mountains National Park, and Maiella National Park — perfect for hiking, biking, trail running, and spotting the highest peaks of the Apennine Mountain Range. Cyclists can enjoy the Bike to Coast cycle path, a 131 km (81.4 mile) route running along the Adriatic coast from Pescara to Vasto. History and architecture lovers will appreciate sites like Basilica di Santa Maria di Collemaggio, Centro Storico di Sulmona, Santo Stefano di Sessanio, Abbey of San Giovanni in Venere, and the Medieval Village of Pacentro. For a uniquely tranquil experience, visit the enchanting Gardens of Ninfa. Abruzzo is also a fabulous winter skiing destination and keeps traditions alive with events like Transumanza, the seasonal migration of livestock, primarily sheep, between the high-altitude pastures of the region. With its mountain majesty, historic villages, flavorful cuisine, and coastal charm, Abruzzo offers something unforgettable for every traveler.Tourissimo Tips:More info on the trabocchi coast: https://www.tourissimo.travel/blog/abruzzos-trabocchi-coastAbruzzo Bike to Coast is a beautiful bike path along the coast: https://www.tourissimo.travel/blog/cycling-along-abruzzos-coastMoliseOne of Italy's most untouched and lesser-known regions, Molise is famously nicknamed “the region that doesn't exist,” though it's rich in history, traditions, and natural beauty. This quiet region offers a mix of beaches and mountains, including part of the National Park of Abruzzo within the Apennines mountain range, filled with abundant wildlife, hiking trails, and winter ski opportunities. Tourissimo Tip–The Region That Doesn't Exist: https://www.tourissimo.travel/blog/the-italian-region-that-doesnt-existThe capital city, Campobasso, is home to notable sites like Monforte Castle and several Romanesque churches, while the charming coastal town of Termoli draws visitors for its beaches, trabucchi (historic fishing huts now serving fresh seafood), and local specialties like brodetto, a traditional seafood stew. Along the Molise coast in Termoli, dining at a trabucchi offers fresh catches with a side of Adriatic views. History buffs should visit the Samnite ruins in the Pietrabbondante archaeological area, the well-preserved Saepinum Archaeological Area, and landmarks like Lago di Castel San Vincenzo, the Cathedral of Saint Mary of the Purification, Monforte Castle, and the Basilica of Saint Mary of Sorrow. A must-see is the Marinelli Bell Foundry, founded in 1339. It's the oldest continuously operating bell foundry in the world, Italy's oldest family business, and the official provider of bells to the Vatican. Food lovers can sample Cavatelli, a local pasta specialty, paired with Tintilia, a rare red wine unique to Molise. The region is also home to seven one-star Michelin restaurants and several local food tours that showcase its rustic culinary traditions. While Molise's quiet charm and untouched landscapes make it a special destination, visitors should note that English is not widely spoken, making it a truly authentic Italian experience for those eager to explore one of the country's hidden gems.Southern Italy: Sun, Sea, and Ancient WondersCampania The birthplace of Neapolitan pizza, the Mediterranean Diet, and Mozzarella di Bufala, Campania is one of Italy's most vibrant and culturally rich regions. Home to the bustling regional capital Naples (Napoli), it boasts some of the country's most iconic destinations, including Pompeii, the stunning Amalfi Coast, and the tranquil Cilento Coast.Along the sparkling, deep-blue waters of the Golfo di Napoli, you'll find must-visit coastal towns like Positano, Amalfi, and Ravello, as well as the famous islands of Ischia, Capri, and the colorful Procida. Visitors can hike the breathtaking Path of the Gods, explore the hauntingly preserved ruins of Archaeological Pompeii, forever shadowed by the gray cone of Mt. Vesuvius, and savor the region's culinary gems like ultra-fresh seafood and crisp Falanghina wine.History and culture lovers shouldn't miss Sansevero Chapel Museum, San Carlo Theatre, the Catacombs of San Gennaro, and the lush Villa Cimbrone Gardens. Campania also impresses with its historic castles, including the Royal Palace of Caserta, Ovo Castle, and Castello Aragonese d'Ischia. Wine enthusiasts should head to the province of Avellino, known for producing some of the best wines in southern Italy.Tourissimo Tip–Wine is also grown inland on the Amalfi Coast, and there are some vines that are 250 years old (pre-phylloxera): https://www.tourissimo.travel/blog/old-vines-on-the-amalfi-coastNature lovers will be drawn to the Cilento, Vallo di Diano, and Alburni National Park, a UNESCO World Heritage Site celebrated for its biodiversity, dramatic landscapes, and cultural heritage, featuring ancient ruins like Paestum and Velia, the majestic Padula Charterhouse, and idyllic coastal villages.Campania is also a paradise for food lovers, home to 51 Michelin-starred restaurants, including one three-star, eight two-star, and forty-two one-star establishments. From world-famous landmarks to hidden treasures, Campania offers an irresistible blend of history, nature, food, and coastal charm.CalabriaWith its rugged coastlines, dramatic landscapes, and hidden treasures, Calabria is a must-visit region in southern Italy. Known for its bold flavors and rich culinary traditions, visitors should sample 'Nduja, a spicy, spreadable sausage paste, and the region's famous Calabrian chiles. The local cuisine embraces cucina povera, a tradition of simple, hearty dishes featuring handmade pasta made with just flour and water. Calabria offers a growing fine dining scene with six one-star Michelin restaurants. For nature lovers, Calabria is home to three stunning national parks — Sila, Aspromonte, and Pollino — ideal for hiking, wildlife spotting, and immersing in untouched landscapes. Along the coast, Capo Vaticano stands out as one of the world's most beautiful beaches, offering breathtaking views and crystal-clear waters. History buffs and castle enthusiasts can explore impressive fortresses like Castello Ruffo di Scilla, Castello Murat, Castello di Le Castella, and Castello Aragonese. Don't miss charming towns and villages such as Tropea, famous for its clifftop views and beaches, as well as Scilla, Pentedattilo, and Le Castella. With its authentic culture, stunning coastlines, flavorful cuisine, and rich history, Calabria remains one of Italy's most captivating yet underrated regions.Tourissimo Tip–Way off the beaten path, lies a  unique museum in Mammola, Calabria https://calabriastraordinaria.it/en/news/visit-to-musaba-the-sistine-chapel-of-calabriaPugliaKnown as the Maldives of Italy, Puglia is a sun-drenched region celebrated for its whitewashed hill towns, ancient olive groves, and miles of stunning coastline. With a dry Mediterranean climate and scenery that often feels more Greek than Italian, Puglia is famed for its beaches in Salento, crystal-clear waters, and charming seaside towns. One of its most iconic sights is the fairytale-like trulli houses of Alberobello, a UNESCO World Heritage Site. This region is also a food lover's paradise, offering specialties like Orecchiette pasta with turnip greens, the classic Fave e Cicoria (fava bean purée with wild chicory), and fresh seafood paired with crisp vegetables. Wine lovers can savor Primitivo, a bold local red. For fine dining, the region boasts nine one-star Michelin restaurants, blending rustic flavors with refined culinary creativity.Puglia is dotted with unique cities and towns worth exploring, including Locorotondo, Otranto, Lecce, Monopoli, Ostuni, Gallipoli, Bari, Alberobello, and Polignano a Mare. Nature and history enthusiasts will enjoy visiting extraordinary sites like the Grotte di Castellana, the dramatic Cave of Poetry, the ancient Basilica San Nicola, and the scenic Gargano Peninsula. With its thousand-year-old olive trees, Puglia is the largest olive oil producer in the world, known for its strong, spicy oils. The locals here are famously warm and welcoming, going out of their way to make visitors feel at home.Puglia's blend of natural beauty, rich tradition, and heartfelt hospitality makes it one of Italy's most captivating and underrated destinations.Tourissimo Tip–Here are some of the gems of Puglia: https://www.tourissimo.travel/blog/some-of-the-gems-of-pugliaBasilicataBasilicata, a remote yet captivating region with a population of just 500,000, offers a wealth of unique experiences despite its secluded location. Among its most intriguing destinations are the ghost town of Craco and the ancient cave city of Matera, both steeped in history and cinematic charm. Other towns worth visiting include Maratea and Palombaroa, each offering its own cultural and scenic appeal.Tourissimo Tip–Matera is magical! https://www.tourissimo.travel/blog/destination-highlight-matera-the-city-of-stonesThe region is rich in historical and religious landmarks, such as the Crypt of Original Sin with its remarkable frescoes, and the medieval Melfi Castle. Don't miss the towering Statue of Christ the Redeemer in Maratea, a striking monument that overlooks the Tyrrhenian coast.For a taste of local flavor, try Peperoni Cruschi—crispy, sun-dried peppers that are a beloved regional delicacy. Basilicata is also known for its exceptional wines, especially the bold, full-bodied reds of Aglianico del Vulture DOC, made primarily from the Aglianico grape. White wine lovers will appreciate the region's Greco di Tufo and Fiano varietals as well. Basilicata also has a total of 14 one-star Michelin restaurants. Adventurers can experience an adrenaline rush on The Angel's Flight, a giant zip line that offers stunning views and a thrilling ride through the Lucanian landscape.SicilySicily, the largest island in the Mediterranean Sea, is a world of its own, offering a diverse landscape of coastlines, mountains, and magical towns such as Cefalù, Palermo, Taormina, Catania, Noto, Agrigento, and Syracuse. Palermo serves as the cultural and diplomatic capital of the region, while Catania stands as its business hub.A volcanic island and UNESCO World Heritage Site, Sicily boasts a rich collection of cultural and natural treasures. Highlights include the awe-inspiring Valley of the Temples, the active volcano Mount Etna, the stunning Duomo di Cefalù, and the picturesque islands of Stromboli, Bella, and Ortigia. The region is also home to the renowned Baroque Triangle in the Val di Noto region of southeastern Sicily, where the eight towns of Caltagirone, Militello Val di Catania, Catania, Modica, Noto, Palazzolo Acreide, Ragusa, and Scicli have been recognized by UNESCO for their outstanding examples of late Baroque architecture.Sicily's culinary scene is just as impressive. Indulge in traditional Sicilian cannoli, filled with sheep's milk ricotta cheese and always stuffed fresh to order. Take a street food tour to savor local favorites like arancini, and don't miss sipping on a glass of Nero d'Avola, one of Sicily's most famous wines. The region is also internationally celebrated for its top-tier agriculture and winemaking.For a taste of authentic Italian charm beyond the tourist trail, explore the towns featured in I Borghi Più Belli d'Italia—Italy's list of its most beautiful hidden gems. Tourissimo Tip–This is a great tip for all 20 regions of Italy. Find out more here: https://www.tourissimo.travel/blog/the-most-beautiful-small-towns-in-italyFood lovers will be delighted to know that Sicily is also home to 23 Michelin-starred restaurants, including three two-star establishments and twenty with one star.Tourissimo Tip–If you visit Corleone, you should definitely learn about the legacy of the Mafia. We in North America tend to have a romanticized view of the mafia, but for the locals, the history is more brutal. See some photos and learn more here: https://www.tourissimo.travel/blog/letizia-battaglia-groundbreaking-photojournalist-who-fearlessly-documented-the-mafia-in-her-native-sicilySardiniaSardinia, the second-largest island in the Mediterranean after Sicily, is a rugged, rural paradise known for its natural beauty, deep-rooted traditions, and ancient history. The island is home to features like the Apennine Coast, the Adriatic Coast, and the Apennine Mountains. Most of Sardinia's population lives in the capital region of Cagliari, but much of the island remains untouched, offering visitors a glimpse into authentic Italian island life.One of Sardinia's most fascinating distinctions is that the Barbagia region is recognized as a Blue Zone—an area with an unusually high number of centenarians. This longevity is attributed to the region's healthy diet, active lifestyle, and strong sense of community. For outdoor enthusiasts, inland Sardinia offers some of the best biking and hiking experiences in all of Italy.Tourissimo Tip–What is a Blue Zone? https://www.tourissimo.travel/blog/blue-zoneThe island's coastlines are just as enticing. Costa Smeralda is often described as paradise on earth, with stunning beaches like Spiaggia di Tuerredda, Cala Goloritzé, and Spiaggia di Porto Giunco perfect for sunbathing and swimming. Don't miss the La Maddalena Archipelago National Park (Parco Nazionale dell'Arcipelago di La Maddalena), a protected area with crystal-clear waters and pristine landscapes.Charming towns such as Alghero, Bosa, and Cagliari add to the island's appeal. Many of Sardinia's towns are nestled in the mountains located in the island's center, offering a peaceful and scenic escape.Cultural and historical attractions abound. Must-see sites include the Nora Archaeological Park, Bastione di Saint Remy, Parco Archeologico Naturalistico di Santa Cristina, and the Museo Archeologico Nazionale di Cagliari. For an unforgettable natural wonder, venture into the Frecce delle grotte srl and Neptune's Grotto, stunning sea caves accessible by boat or stairs carved into cliffs.Sardinia is also home to a unique ancient civilization. Scattered across the island are over 7,000 nuraghe—megalithic stone structures built during the Nuragic Age (c. 1900–730 BC). These mysterious, tower-like buildings are the island's most iconic symbol, and some scholars believe there were once over 10,000 nuraghe structures in total.Religious architecture also impresses, with highlights like the Cattedrale di Santa Maria Assunta e Santa Cecilia, the Church of the Holy Trinity of Saccargia, and the Basilica di San Simplicio showcasing Sardinia's spiritual and artistic heritage.Sardinian cuisine reflects its mountainous geography. Surprisingly, for an island, the diet leans more toward land-based ingredients than seafood. Signature dishes include Porceddu (roast pig), Fregola (a traditional Sardinian pasta), and the adventurous Casu marzu—a sheep's milk cheese intentionally infested with live maggots and considered a local delicacy. Sardinia also holds 16 one-star Michelin restaurants.To accompany these flavors, try a glass of Cannonau red wine, known for its high polyphenol content and potential health benefits, or the refreshing Vermentino white wine, perfect for warm Mediterranean days.Tourissimo Tip–Magic Trick or Pasta Making? https://www.tourissimo.travel/blog/magic-trick-or-pasta-making From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio!From the Alps to the Mediterranean, each Italian region is a world of its own. Want to see it all? Check out Tourissimo's amazing trip planning and Italian information at tourissimo.travel! Buon viaggio! 

In this episode of the Heal Your Hormones podcast, Dr. Danielle Desroche discusses quick and easy lunch ideas specifically tailored for individuals with PCOS. She emphasizes the importance of meal planning and provides seven nutritious meal options that are rich in protein, fiber, and healthy fats to support blood sugar levels and overall hormone balance. The conversation covers various recipes, including grilled chicken salad, quinoa bowls, tuna salad wraps, and more, all designed to be simple and easy to prepare in advance.Chapters00:00 Introduction to PCOS Lunch Ideas03:14 Healthy Lunch Options: Grilled Chicken Salad05:32 Quinoa and Roasted Veggie Bowl07:18 Tuna Salad Lettuce Wraps09:33 Egg and Veggie Scramble10:30 Cauliflower Rice Stir-Fried Chicken Bowl12:24 Zucchini Noodles with Pesto and Salmon13:41 Chickpea and Avocado Salad15:28 Common Themes in PCOS Lunches16:51 Conclusion and Future Topics-----Have a topic you want covered? DM me on Instagram @drdanielle.nd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Schedule your strategy call here.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Join the newsletter here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fullscript Supplement Dispensary⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Jenna and Willie help a few male listeners out with their tricky social situations in an edition of ‘Guy Code.' Also, lifestyle expert Meredith Sinclair shares a few wardrobe ideas for men and women to help reset your spring fashion. Plus, TODAY culinary producer Katie Stilo shares a delicious creamy pesto chicken recipe that's perfect for a busy weeknight. 

Un primo piatto per celebrare l'inizio dell'autunno, ma adatto a tutte le stagioni.

Did you know that half of your skills are unnecessary, and the other half are barely used? Shocking, right? Today, Dr. Terri Levine shares her wisdom on how you can unleash your hidden skills using a simple framework she calls PESTO. She uses an analogy of her hiking backpack, filled with gear she already owns, meaning she doesn't need to buy anything else this year.  Dr. Terri Levine believes we all have an overflowing backpack of talents and experiences—it's time to unpack them!   Key Highlights From The Episode: [00:39] Dr. Terri Levine's backpack story [01:17] The truth about your skills and knowledge [01:42] A challenge for you [02:22] How to improve your content production using the PESTO pillar framework [03:40] Join Dr. Terri Levine's community Heartrepreneurs.com    Golden Nuggets: • Half of your skills are unnecessary, and the other half are barely used. You have huge untapped resources—a backpack of knowledge that you can share, yet you hardly ever do. [00:48] • Every now and then, check what's trending. If something's up your alley, simply share a story about it and how it relates to you on a personal level. [02:38]    Let me help you grow your coaching business:  Join The Live Well Earn Well Mastermind™ Today: https://livewellearnwellmastermind.com/    Let's hop on a quick Zoom call so I can focus on your business and offer my help: https://zoom.us/meeting/register/tJ0tdO2urTooHNLQuGo9wdTbJHJcjXoghF8N#/registration    Oh yeah, and please join free Facebook community here: Heartrepreneurs.com   Want More!? Subscribe to this podcast on your favorite podcast platform… Apple: https://podcasts.apple.com/us/podcast/live-well-earn-well-for-coaches-consultants/id1585895518  Spotify: https://open.spotify.com/show/5OjsOxN7MqwKio4Ae6vSMQ  Or anywhere else podcasts are found!    Watch all the episodes and more to gain more insight on YouTube: https://www.youtube.com/@coachterri/videos   Please connect with me on social: Instagram: https://www.instagram.com/mentorterrilevine  Facebook: https://www.facebook.com/MentorTerriLevine  LinkedIn: https://www.linkedin.com/in/terrilevine/ 

This fresh, uncooked sauce can be made in jarringly different ways, even with the same ingredients. Anney and Lauren dip into the history and science of pesto.See omnystudio.com/listener for privacy information.

Hello to our lovely coven, happy Wednesday! Katie is looking out of this world today, and recounts her evening at the Sports Illustrated 60 event (and everyone there was so sexy), our love for tray passers and techniques to keep em coming, Dayna confesses her love for Bo Burnham, Pesto the Penguin is in the basement (#freepesto), and their takes on singing in the theater. If you haven't checked out our merch yet, please support our show and show off your love for Disrespectfully by repping our official swag :) K Love ya bye! Thank you to our sponsors! LOLAVIE: Get 15% off LolaVie with the code DISRESPECTFULLY15 at https://www.lolavie.com #lolaviepod LUME: Control Body Odor ANYWHERE with @lumedeodorant and get 15% off with promo code DISRESPECTFULLY at https://LumeDeodorant.com! #lumepod HONEYLOVE: Get Up to 50% off @honeylove by going to https://honeylove.com/DISRESPECTFULLY! #honeylovepod  GOOD AMERICAN: Shop now at https://GoodAmerican.com/disrespectfully. Use Promo Code DISRESPECTFULLY for $50 OFF your first pair. Don't forget to select “podcast” at checkout and choose our show to let them know we sent you!  DIME: Go to https://dimebeautyco.com for 25% off sitewide with code HOLIDAY25, but hurry, it's only for a limited time!   UNCOMMON GOODS: To get 15% off your next gift, go to https://uncommongoods.com/disrespectfully  Need Advice? Have a Heauxmetown Hero Story? Send your questions/stories to disrespectfullypod@gmail.com and we may answer your questions on the show! Connect with the Coven! Facebook: https://www.facebook.com/groups/1930451457469874 Reddit: https://www.reddit.com/r/disrespectfullypod/  Listen to us on Apple: https://podcasts.apple.com/us/podcast/disrespectfully/id1516710301 Listen to us on Spotify: https://open.spotify.com/show/0J6DW1KeDX6SpoVEuQpl7z?si=c35995a56b8d4038 Follow us on Social! Disrespectfully Instagram: https://www.instagram.com/disrespectfullypod/?hl=en Disrespectfully Tiktok: https://www.tiktok.com/@disrespectfullypod?_t=8icuQMhG3jz&_r=1 Katie Maloney Instagram: https://www.instagram.com/musickillskate/?hl=en Dayna Kathan Instagram: https://www.instagram.com/daynakathan/?hl=en   Buy our merch! https://disrespectfullypod.com/   Disrespectfully is an Envy Media Production.

This week on Page 7 Holden wants to watch an ape give cunnilingus to another ape (who doesn't tbh), Jackie's feelin' herself to Ashnikko, and thankfully her fam is doin' fine but still without power due to ole Milton, MJ's got the lip reader transcript of Nicole Kidman and Salma Hayek's incredibly awkward encounter at a Balenciaga! show, once again there is Chappell Roan banter about pressures of fame as well as her TikTok's from this past weekend, Olivia Rodrigo got to meet Pesto the penguin so please send it to Holden and he'll tell you her falling in that pit was karma for meeting such a wretched beast, MJ GOT HIS ORVILLE PECK TICKETS! Jessica Chastain publicly tweeted out about her refund not being enough for her TV not working on her Jetblue flight and people on Twitter got maaaaaad (at Jessica ofc), Raw Dawgin' flights is the new trend no one asked for, but lets hope it leads to some personal self reflection, Mariah Carey REFUSES to be seen under overhead lighting, but that's not stopping her from getting the 30th anniversary of 'All I Want For Christmas Is You' ready to drop like a nuclear weapon, Jackie Stewart's slinging turkey tips even tho IT'S NOT EVEN HALLOWEEN YET, JACKIE, Burger King introduces A BIG SLOPPY DIP CUP of Hidden Valley Ranch, finally a ranch cup fit for a WHOPPER...Over in Celebrity Conspiracy Corner: Was Secret Lives of Mormon Wives a PSY OP and an ad from BIG SODA TO KEEP US IN THEIR SUGARY CLUTCHES!?!? A List of unbelieve facts about pop music and the weirdos that make it, Holden comes in at the last moment with info on the new T Swift Era Tours Book to much roasting, the Blindz and even MOOOOOORE!   Want even more Page 7? Support us on Patreon! Patreon.com/Page7Podcast  Subscribe to SiriusXM Podcasts+ on Apple Podcasts to listen to ad-free new episodes.

Blair Socci returns to Bananas! She talks to Kurt and Scotty about how someone bought a Temu croissant lamp that ended up being a real croissant, a soccer player injured after a hefty sneeze, Pesto the massive penguin chick and a man receives a $1.4 million speeding ticket! Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/4a61tMk Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 1554 brought to you by: Chubbies: Checkout at https://chubbiesshorts.com and use code (Hardfactor20) to get 20% off your order.  Lucy: Go to www.lucy.co/hardfactor and use promo code (HARDFACTOR) to get 20% off your first order. Lucy offers FREE SHIPPING and has a 30-day refund policy if you change your mind. Factor Meals: Head to www.factormeals.com/hardfactor50 and use code hardfactor50 to get 50% off your first box plus 20% off your next month. Prize Picks: Download the PrizePicks app today and use code HARDFACTOR and get $50 instantly when you play $5! My Morning Kick: Go to roundhouseprovisions.com/HARDFACTOR for up to 44% off your regular-priced order. That is if you want to experience smoother digestion, a boost of energy, and just an overall healthier body like Chuck Norris Timestamps (00:03:50) Huge update on the KY Sheriff that shot and killed a Judge in his chambers (00:06:25) Santa Monica man invents way to keep homeless people from sleeping in his carport (00:18:15) The newest animal sensation sweeping the internet, a Penguin named Pesto is taking the world by storm (00:22:40) Man abducted when he was 6 years old in 1951 is reunited with family members thanks to online DNA testing (00:25:55) North Korea launches more shit balloons at South Korea, this time causing flight delays and cancellations at airports (00:33:25) GDP and National Debt Update isn't looking great! (00:34:20) More US military being deployed to Middle East (00:34:35) Bridgerton Themed ball leaves attendees angry and disappointed in how un-Bridgerton the event was, but they did have a stripper! For more Hard Factor go to patreon.com/hardfactor Learn more about your ad choices. Visit megaphone.fm/adchoices

This Week Grace and Mamrie discuss TikTok Reels, products behind locked glass doors, Mamrie's Birthday celebrations, Uber cancellations, Moo-deng the Pygmy Hippo and Pesto the Penguin. Go to http://bombas.com/tmgw and use code tmgw for 20% off your first purchase. Go to http://hungryroot.com/tmgw to get 40% off your first delivery and get your free veggies. Go to http://shopify.com/weird to sign up for a $1-per-month trial period. Go to http://zocdoc.com/weird to find and instantly book a top-rated doctor today. Go to http://seed.com/weird and use code 25TMGW to get 25% off your first month. Learn more about your ad choices. Visit megaphone.fm/adchoices

Thank you sponsors! LoloVie https://www.lolavie.com/ use code: SESH  Jenni Kayne https://www.jennikayne.com/ use code: SESH   Time Stamps 0:14 - Welcome back 0:55 - Our Doppelgängers  3:17 - trip down memory lane 6:17 - WELCOME BACK 7:41 - Coca-Cola Oreos 14:42 - Baja Blast gelato  18:11 - The Secret Lives of The Mormon Wives 28:58 - Vegas trip 46:09 - Candle whizzer must be stopped 57:08 - wicked with a bread pan 1:01:28 - Chili's plz sponsor us 1:05:40 - Collin Gosselin reveals horrific CA 1:34:32 - Kate was on Special Forces 1:38:13 - Pesto the Penguin The Sesh Merch: thesesh.shop   Submit your “Am I Getting Played?” stories here: https://forms.gle/ZQnpxyhMwXJapKs87  Listen on Spotify: https://spoti.fi/3fjR2s Listen on Apple Podcasts: https://apple.co/3go1X5s Subscribe to our YouTube channel: https://bit.ly/3fCx7H3  Topic request form: https://forms.gle/yTyFVRcEkpktU6Q87     Spicy + CSI Submission form: https://forms.gle/EKXkE2j1hxoMmyma8 Life Advice form: https://forms.gle/z8aSz8JUPUJuxctn7  AITA form: https://forms.gle/G7cLpMLGWNBC3NZy9 Check out our other podcasts! Lights Out https://bit.ly/3n3Gaoe Planet Sleep https://linktr.ee/planetsleep Mile Higher Podcast https://bit.ly/3uDwZ2Y  Kendall's CBD Brand, Higher Love Wellness: https://higherlovewellness.com/   Follow us on social media @the_seshpodcast  TikTok: https://bit.ly/3r3k9I2  IG: https://bit.ly/3a9t6Xr TW: https://bit.ly/2XH4C2A Join our Discord! https://discord.gg/milehigherhomies   Kendall: @kendallraeonyt IG: https://bit.ly/3gIQPjI   TW: https://bit.ly/2XLsLFn   YT: https://bit.ly/3abKWsS   TikTok: https://bit.ly/3JxPJFx    Janelle: @janelle_fields_ YoutTube Channel: https://bit.ly/3JNOBx8   IG: https://bit.ly/2DyP1eE   TW: https://bit.ly/2DrboD1   TikTok: https://bit.ly/3BrWBkO     Karelly: @karell.y IG: https://bit.ly/2TcxnoD   TW: https://bit.ly/3f9ngcN  Kositas by Karelly- kositas.co    Sydney: @syd_b93    IG: https://bit.ly/3LR0zHY  TikTok: https://bit.ly/3OL4aJU  Podcast sponsor inquires: adops@audioboom.com    Music By: Mile Higher Boys YT: https://bit.ly/3fJrDZ8 IG: https://bit.ly/3kDle5s    Send Us Mail & Art  8547 E Arapahoe Rd Ste J # 233 Greenwood Village, CO 80112   Welcome to The Sesh Podcast hosted by cousins and best friends, Kendall & Janelle! Kendall is a YouTube content creator focusing on True Crime and raising awareness for missing persons cases, and Janelle is a mental health professional with a Master's in Clinical Mental Health Counseling. Our show is focused on a variety of topics including current events, pop culture, commentary, and a little true crime. Come hang out with us every Wednesday!

On this episode, C&Whit are making a pasta along with some tea