Podcasts about catalyzed

Recounting both firsthand experience and repro-political history, Kelley Fox and Rev. Terry Williams help listeners see the explicit connection between anti-abortion ideology and modern political violence in the U.S. Catalyzed by the recent assassination of Minnesota lawmaker Melissa Hortman, Kelley and Terry explain why it's no big surprise that Rep. Hortman's assassin also targeted abortion workers in his destructive quest. Revisiting historical examples of anti-abortion violence, this episode also provides listeners with concrete steps to achieve focus, maintain perspective, and keep pressing forward in the fight for abortion justice and reproductive freedom. Links to discussed show notes: Abortion providers devastated by political killings, hit list: thehill.com/policy/healthcare/5353386-abortion-providers-targeted-missouri-shooting/amp 'God Sent the Shooter,' & Other Lies by Political Extremists, by Rev. Terry Williams: www.faithchoiceohio.org/blog/2019/5/31/god-sent-the-shooter The Army of God: newreligiousmovements.org/a/army-of-god Video of "Cry Night" at an Evangelical Camp: www.tiktok.com/@emhahee/video/7246223464242105643 PRIDE 2025 with Faith Choice Ohio: www.faithchoiceohio.org/pride Finding Small Joys in a Summer of Turmoil, by Kelley Fox: www.faithchoiceohio.org/blog/finding-small-joys-in-a-summer-of-turmoil Music by Korbin Jones

In 'Meanwhile', Jacqueline Woodson and Catherine Gund weave together the words of literary legends to explore the intersection of art, grief, and social justice.Description: James Baldwin, Toni Morrison, Muhammad Ali and Nina Simone are some of the artists featured in the moving new film “Meanwhile”, from National Book Award-winner Jacqueline Woodson and Emmy-nominated producer & director Catherine Gund. Their meditations on grief, art, breath and more are beautifully woven together as the film poses the question, how do you keep breathing amidst the chaos? Catalyzed by the Covid-19 pandemic and the police killing of George Floyd, Gund and Woodson tap into our shared existence. The artists featured in the docu-poem, with a haunting soundtrack by Meshell Ndegeocello, work through questions of race, political violence, resistance and identity — so much of what shapes our lives and relationships. “This is not a love letter to this country but to us inside this country,” says Woodson in the film. “We see us. We love us. We make eye contact and nod to us”. In this conversation with Laura Flanders, the trio of longtime friends discuss the film from Aubin Pictures, the losses they experienced in the 80s, and how the arts and poetry can compel us to enact change. Can we reclaim the “meanwhile”? All that, plus a commentary from Laura on hers.Guests:•  Catherine Gund: Producer & Director, Meanwhile; Filmmaker & Founder, Aubin Pictures•  Jacqueline Woodson: Writer & Performer, Meanwhile; Author, Brown Girl Dreaming; Founder, Baldwin for the Arts;  The Elders Project, ColumbiaWatch the special report released on YouTube May 16th 5pm ET; PBS World Channel May 18th, and on over 300 public stations across the country (check your listings, or search here via zipcode). Listen: Episode airing on community radio (check here to see if your station airs the show) & available as a podcast May 21st.Full Conversation Release May 16th, 2025: While our weekly shows are edited to time for broadcast on Public TV and community radio, we offer to our members and podcast subscribers the full uncut conversation. ARE YOU AUDACIOUS? SUPPORT OUR RESISTANCE REPORTING FUND! Help us continue fighting against the rise of authoritarianism in these times. Please support our Resistance Reporting Fund. Our goal is to raise $100K. We're at $35K! Become a sustaining member starting at $5 a month! Or make a one time donation at LauraFlanders.org/Donate RESOURCES:Watch the broadcast episode cut for time at our YouTube channel and airing on PBS stations across the country  Related Laura Flanders Show Episodes:•  Ask Angola Prison: What Difference Can a Play Make?  Watch / Listen:  Episode and Full Conversation•  Survival Guide for Humans Learned from Marine Mammals with Alexis Pauline Gumbs: Watch / Listen:  Episode and Full Conversation  •  V (formerly Eve Ensler): Reckoning with Our Past, Transforming the Future: Watch / Listen Related Articles and Resources:•  Jacqueline Woodson:  Kennedy Center Education Artist-in-Residence (2022-2024)•  Catherine Gund's Meanwhile:  A gorgeous, quietly energetic, and moving meditation on Black resilience and world-making in the face of interminable violence. by Brittany Turner, March 2025, The Brooklyn Rail•  Ivy Young, D.C. journalist, poet, and activist dies at 75: A life of service dedicated to community building. By Staff reports, June 6, 2023, Washington Blade•  Gai Gherardi, legendary co-founder of L.A. Eyeworks, Garrett Leight *Recommended book:“Brown Girl Dreaming” by Jacqueline Woodson. Get the Book*(*Bookshop is an online bookstore with a mission to financially support local, independent bookstores. The LF Show is an affiliate of bookshop.org and will receive a small commission if you click through and make a purchase.) Full Episode Notes are located HERE. Laura Flanders and Friends Crew: Laura Flanders, along with Sabrina Artel, Jeremiah Cothren, Veronica Delgado, Janet Hernandez, Jeannie Hopper, Gina Kim, Sarah Miller, Nat Needham, David Neuman, and Rory O'Conner. FOLLOW Laura Flanders and FriendsInstagram: https://www.instagram.com/lauraflandersandfriends/Blueky: https://bsky.app/profile/lfandfriends.bsky.socialFacebook: https://www.facebook.com/LauraFlandersAndFriends/Tiktok: https://www.tiktok.com/@lauraflandersandfriendsYouTube: https://www.youtube.com/channel/UCFLRxVeYcB1H7DbuYZQG-lgLinkedin: https://www.linkedin.com/company/lauraflandersandfriendsPatreon: https://www.patreon.com/lauraflandersandfriendsACCESSIBILITY - The broadcast edition of this episode is available with closed captioned by clicking here for our YouTube Channel

In 'Meanwhile', Jacqueline Woodson and Catherine Gund weave together the words of literary legends to explore the intersection of art, grief, and social justice.Description:  James Baldwin, Toni Morrison, Muhammad Ali and Nina Simone are some of the artists featured in the moving new film “Meanwhile”, from National Book Award-winner Jacqueline Woodson and Emmy-nominated producer & director Catherine Gund. Their meditations on grief, art, breath and more are beautifully woven together as the film poses the question, how do you keep breathing amidst the chaos? Catalyzed by the Covid-19 pandemic and the police killing of George Floyd, Gund and Woodson tap into our shared existence. The artists featured in the docu-poem, with a haunting soundtrack by Meshell Ndegeocello, work through questions of race, political violence, resistance and identity — so much of what shapes our lives and relationships. “This is not a love letter to this country but to us inside this country,” says Woodson in the film. “We see us. We love us. We make eye contact and nod to us”. In this conversation with Laura Flanders, the trio of longtime friends discuss the film from Aubin Pictures, the losses they experienced in the 80s, and how the arts and poetry can compel us to enact change. Can we reclaim the “meanwhile”? All that, plus a commentary from Laura on hers.“. . . Having lost people so early and in such quick succession and under such an awful oppressive situation [of AIDS in the 80s], . . . each one of those hit so hard. We wrote and we made movies, and we had these elaborate memorials, and we did things to process and grieve. I am really holding on to that approach to death and dying as we get older, because I don't wanna ever not care.” - Catherine GundGuests:•  Catherine Gund: Producer & Director, Meanwhile; Filmmaker & Founder, Aubin Pictures•  Jacqueline Woodson: Writer & Performer, Meanwhile; Author, Brown Girl Dreaming; Founder, Baldwin for the Arts;  The Elders Project, Columbia Full Conversation Release: While our weekly shows are edited to time for broadcast on Public TV and community radio, we offer to our members and podcast subscribers the full uncut conversation. These audio exclusives are made possible thanks to our member supporters.Watch the special report released on YouTube May 16th 5pm ET; PBS World Channel May 18th, and on over 300 public stations across the country (check your listings, or search here via zipcode). Listen: Episode airing on community radio (check here to see if your station airs the show) & available as a podcast May 21st. ARE YOU AUDACIOUS? SUPPORT OUR RESISTANCE REPORTING FUND! Help us continue fighting against the rise of authoritarianism in these times. Please support our Resistance Reporting Fund. Our goal is to raise $100K. We're at $35K! Become a sustaining member starting at $5 a month! Or make a one time donation at LauraFlanders.org/Donate RESOURCES:Watch the broadcast episode cut for time at our YouTube channel and airing on PBS stations across the country Full Episode Notes are located HERE. Related Laura Flanders Show Episodes:•  Ask Angola Prison: What Difference Can a Play Make?  Watch / Listen:  Episode and Full Conversation•  Survival Guide for Humans Learned from Marine Mammals with Alexis Pauline Gumbs: Watch / Listen:  Episode and Full Conversation  •  V (formerly Eve Ensler): Reckoning with Our Past, Transforming the Future: Watch / Listen Related Articles and Resources:•  Jacqueline Woodson:  Kennedy Center Education Artist-in-Residence (2022-2024)•  Catherine Gund's Meanwhile:  A gorgeous, quietly energetic, and moving meditation on Black resilience and world-making in the face of interminable violence. by Brittany Turner, March 2025, The Brooklyn Rail•  Ivy Young, D.C. journalist, poet, and activist dies at 75: A life of service dedicated to community building. By Staff reports, June 6, 2023, Washington Blade•  Gai Gherardi, legendary co-founder of L.A. Eyeworks, Garrett Leight   Laura Flanders and Friends Crew: Laura Flanders, along with Sabrina Artel, Jeremiah Cothren, Veronica Delgado, Janet Hernandez, Jeannie Hopper, Gina Kim, Sarah Miller, Nat Needham, David Neuman, and Rory O'Conner. FOLLOW Laura Flanders and FriendsInstagram: https://www.instagram.com/lauraflandersandfriends/Blueky: https://bsky.app/profile/lfandfriends.bsky.socialFacebook: https://www.facebook.com/LauraFlandersAndFriends/Tiktok: https://www.tiktok.com/@lauraflandersandfriendsYouTube: https://www.youtube.com/channel/UCFLRxVeYcB1H7DbuYZQG-lgLinkedin: https://www.linkedin.com/company/lauraflandersandfriendsPatreon: https://www.patreon.com/lauraflandersandfriendsACCESSIBILITY - The broadcast edition of this episode is available with closed captioned by clicking here for our YouTube Channel

Istanbul's mayor is detained over investigations into alleged corruption and terrorism support, Canada inks a $4.2B Arctic radar deal with Australia, Ukraine reports Russian strikes after Putin agreed to a partial truce in consultation with the Trump admin., Germany breaks its debt rules to finance its defense spending boost, the UK's Kemi Badenoch drops her net zero emissions support, Jair Bolsonaro's son takes leave from Brazil's Congress and seeks US political asylum, a US federal judge blocks the Trump admin.'s USAID shutdown, while a US federal judge moves Mahmoud Khalil's deportation case to New Jersey, the US Federal Reserve holds interest rates steady, and a Europol report claims that AI is becoming a powerful catalyst for organized crime. Sources: www.verity.news

In this bonus Q&A with Kami, she shares:Her proudest moment and biggest failure in her career so farA trend that she is following in Talent Development right nowThe biggest challenge she sees in Talent Development todayBooks that have made a big impact on her lifeOne piece of career advice she has for youKami's mission is to support, invest in, value and grow education professionals as leaders. She has spent the past two decades supervising, coaching, and developing urban school and system leaders through a people-centered approach to systemic change. Catalyzed by her own early experiences in the classroom and the lack of adequate preparation she received, she now works with system-level leaders at schools across the nation to create and grow leadership development programming and pathways for educators and school leaders. As a long-time instructor at Columbia's Teachers College, and in recent roles as a Chief Learning Officer and consultant supporting school and district leaders in the areas of leadership development, instruction, and capacity building, she bridges the gap between theory and practice in K-12. She is obsessed with all things leadership development and professional learning and deeply believe that when we invest in education talent, we transform schooling.Connect with Andy Storch here:WebsiteLinkedInJoin us in the Talent Development Think Tank Community!Connect with Kami Lewis Levin:LinkedIn

Today, we're diving deep into the world of educational leadership with our special guest, Kami Lewis Levin. With over two decades of experience in empowering urban school leaders and promoting systemic change, Kami brings invaluable expertise to our discussion. As an instructor at Columbia's Teacher College and Chief Learning Officer for various nonprofits, she plays a pivotal role in addressing critical issues in K-12 education, notably through her work with the Literacy Design Collaborative.In this episode, we tackle:The challenges of outdated education modelsThe decline in students' reading and math skills, and the urgent need for critical thinking developmentKami collaborates with school districts to create leadership pathways for educators, effectively addressing the prevalent teacher shortage and enhancing career progression opportunitiesParallels between educational and corporate leadership transitions, highlighting the unique hurdles and growth opportunities faced by educators stepping into leadership rolesTune in as we delve into adult learning models, the importance of mindset work for leaders, and the transformative shift from fear-based to trust-based leadership. Whether you're in the educational sector or the corporate world, this episode is packed with insights that promise to inspire and inform your leadership journey. Kami's mission is to support, invest in, value and grow education professionals as leaders. She has spent the past two decades supervising, coaching, and developing urban school and system leaders through a people-centered approach to systemic change. Catalyzed by her own early experiences in the classroom and the lack of adequate preparation she received, she now works with system-level leaders at schools across the nation to create and grow leadership development programming and pathways for educators and school leaders. As a long-time instructor at Columbia's Teachers College, and in recent roles as a Chief Learning Officer and consultant supporting school and district leaders in the areas of leadership development, instruction, and capacity building, she bridges the gap between theory and practice in K-12. She is obsessed with all things leadership development and professional learning and deeply believe that when we invest in education talent, we transform schooling.Connect with Andy Storch here:WebsiteLinkedInJoin us in the Talent Development Think Tank Community!Connect with Kami Lewis Levin:LinkedIn

Monica Coenraads, the mother of a daughter with Rett Syndrome, has played a critical role in catalyzing development of therapies to treat the rare, neurological disease. She co-founded and served as director of research for the Rett Syndrome Research Foundation. She later founded and today serves as CEO of the Rett Syndrome Research Trust. Her work shows how patient organizations can bridge the translational divide and de-risk rare disease drug development for biopharmaceutical companies. We spoke to Coenraads about her experience with Rett syndrome as a mother of a daughter with the condition, how she crafted a scientific agenda for the organizations she founded, and what other rare disease organizations can learn from her experience.

Yurok fisherman and tribal leader Sammy Gensaw and environmental scientist-turned-activist Craig Tucker share the epic story of how Indigenous leadership and non-Indian allyship made the impossible inevitable: the biggest-ever dam removal and salmon restoration in history. It represented a literal watershed moment; unprecedented co-equal decision-making between the tribes and their historical nemesis – the US government. Once complete in 2024, the project will liberate the Klamath river and several tributaries to once again run free across 400-miles from Oregon through California and into the Pacific Ocean. Featuring Sammy Gensaw (Yurok) is the Founding Director of the Ancestral Guard, Artist, Yurok Language Speaker, Singer, Writer, Cultural/Political/Environmental Activist, Regalia Maker, Mediator, Youth Leader & Fisherman. Craig Tucker has 20+ years of advocacy and activism experience, especially working with tribal members, fishermen and farmers in the Klamath Basin on dam removal, traditional fire management, gold mining, and water policy, and is the founder and Principal of Suits and Signs Consulting. Resources Indigenous Forum – Undam the Klamath! How Tribes Led the Largest River Restoration Project in US History | Bioneers 2023 Credits Executive Producer: Kenny Ausubel Written by: Kenny Ausubel Senior Producer and Station Relations: Stephanie Welch Host and Consulting Producer: Neil Harvey Program Engineer and Music Supervisor: Emily Harris Producer: Teo Grossman This is an episode of the Bioneers: Revolution from the Heart of Nature series. Visit the radio and podcast homepage to learn more.

According to Ramp's (ramp.com) quarterly spend report, Fireflies was the 4th highest AI platform by spend. With over 300,000 customers worldwide and 16M users, Fireflies.ai is operating at some of the largest scale amongst AI companies today. This week on Unsupervised Learning we had Krish Ramineni, Co-founder & CEO of Fireflies on to talk about how he sees AI changing the way we work and conduct meetings, and share his biggest learnings around AI in building Fireflies. (0:00) intro(1:01) how will AI change meetings going forward(4:03) Fireflies' capabilities(8:18) how new models change Fireflies(11:19) shortcomings of current models(16:36) Krish's lack of belief in fine-tuning(26:19) dealing with high inference costs(34:00) taking on incumbents(40:50) what metrics matter most to Fireflies(46:37) how is Fireflies so fast?(54:28) over-hyped/under-hyped(55:11) biggest surprises in building Fireflies(1:01:15) Jacob and Rashad debrief With your co-hosts: @jacobeffron - Partner at Redpoint, Former PM Flatiron Health @patrickachase - Partner at Redpoint, Former ML Engineer LinkedIn @ericabrescia - Former COO Github, Founder Bitnami (acq'd by VMWare) @jordan_segall - Partner at Redpoint

Karen Thomas of Naturally Recovering Autism interviews Zen Honeycutt from Moms Across America on Aluminum, Arsenic, Cadmium, Lead, and Mercury Found in Baby Formula. Catalyzed by the FDA's failure to regulate heavy metals in baby formula, a coalition of consumer advocacy groups commissions testing of 20 different brands. Groups urge the FDA and legislators to protect infants from toxic exposure. Severe health risks posed by these toxic metals include developmental delays, cancer, kidney damage, and neurocognitive difficulties. A coalition of consumer advocacy groups, including Moms Across America, GMOScience, and The New MDS, has uncovered alarming levels of toxic metals in baby formula. Testing of 20 popular brands revealed that 100% of samples contained aluminum and lead, with over half also testing positive for arsenic, mercury, and cadmium. Disturbingly, six formulas contained all five metals in both samples. Notably, aluminum levels in one goat's milk formula were up to 40,000 times higher than other metals tested, far exceeding FDA safety limits. Mercury and cadmium levels in several samples also surpassed allowable limits in drinking water. Despite the FDA's “Closer to Zero” initiative launched in 2021, no substantial regulatory limits have been set, leaving babies vulnerable. Recent efforts, including the Baby Food Safety Act of 2024, which was announced by Congress on May 9, one week after the heads of Moms Across America and GMOScience met with lawmakers and the FDA in D.C. to deliver the results of the baby formula testing, aim to give the FDA authority to regulate and enforce limits on levels of heavy metals found in baby food and potentially formula. Talk points in this podcast: Alarming rates of toxic metals when testing 20 different baby formula brands. 100% of the 40 samples tested contained aluminum and lead. 57% of the samples tested positive for arsenic, 55% for mercury, and 35% for cadmium. Six of the 20 formulas were positive for all five toxic metals in both samples. At 41,000 ppb, aluminum levels in a goat's milk baby formula were 4000 – 40,000x higher than other metals in the formulas tested and exceed limits set by the FDA for maximum safety level of aluminum for a preemie. Levels of mercury in four samples measured above the limit allowed by the FDA in drinking water. Levels of cadmium in both samples of one formula were nearly twice the level allowed in drinking water. The is heightened vulnerability of infants due to their small bodies and rapid cellular growth... Click Here or Click the link below for more details! https://naturallyrecoveringautism.com/197

This week I'm reading from Robert De Filippis' book 'Signals in the Noise: Encountering the Limits of Materialist Science - An Exploration of Consciousness and Reality'."The Signals in the Noise," groundbreaking theories about consciousness are meticulously explored, presenting an avant-garde perspective that stands to challenge our traditional, materialist viewpoints. The author leads us on an intellectual journey, questioning established materialist scientific norms and bringing forward evidence that defies materialist theories of consciousness.The book emphasizes that consciousness persists and can even be enhanced when brain activity decreases, supported by numerous research studies involving psychedelics, near-death experiences, and other instances when brain functions are diminished. This new understanding suggests that consciousness transcends the physical confines of our biological makeup, challenging conventional notions about its origin and nature.Furthermore, the book introduces a transformative perspective on the universe, proposing that what we perceive as material is merely a function of our sensory systems. Based on the author's review of current theories of the composition of the cosmos, we now know everything that exists is composed of energy, with physicality representing deeper qualities that lie out of our reach. Drawing on proven quantum physics, the author presents the theory that the universe's interconnectedness is a product of coherent quantum fields from which everything emerges and takes on the character of separateness and materiality in the 4D or manifest level we experience.In a radical departure from mainstream materialist thought, "The Signals in the Noise" argues that consciousness is a universal phenomenon occurring in varying degrees of complexity across all organisms. The author posits that while the presence of proto-consciousness is universal, the consciousness we experience emerges in the fourth-dimensional or manifest level, an idea that, if widely accepted, can redefine our understanding of life and existence.Finally, the author criticizes the materialist worldview, stating that this ingrained belief system creates many societal, political, religious, and environmental problems. He argues that our obstinate adherence to materialist orthodoxy drives our trajectory toward planetary destruction. Catalyzed by our capitalist system of consumption, this materialist belief system hinders our ability to recognize and correct the adverse effects of our actions."The Signals in the Noise" is a compelling critique of the materialist worldview, challenging our understanding of consciousness, existence, and our place in the universe. It underscores the urgency to redefine our perspectives to avert the catastrophic trajectory that our current beliefs are driving us toward. This book is a radical and thought-provoking read for anyone interested in consciousness, quantum physics, and the future of our planet.BioRobert is a member of The Institute of Noetic Sciences and engages in its activities. And in early 2023, he became a Fellow of the American Institute of Philosophical and Cultural Thought.Amazon link https://tinyurl.com/3u2sxn7uhttps://www.pastliveshypnosis.co.uk/https://www.patreon.com/ourparanormalafterlifeBecome a supporter of this podcast: https://www.spreaker.com/podcast/our-paranormal-afterlife-finding-proof-of-life-after-death--5220623/support.

This week I'm talking to Robert De Filippis about his book 'Signals in the Noise: Encountering the Limits of Materialist Science - An Exploration of Consciousness and Reality'."The Signals in the Noise," groundbreaking theories about consciousness are meticulously explored, presenting an avant-garde perspective that stands to challenge our traditional, materialist viewpoints. The author leads us on an intellectual journey, questioning established materialist scientific norms and bringing forward evidence that defies materialist theories of consciousness.The book emphasizes that consciousness persists and can even be enhanced when brain activity decreases, supported by numerous research studies involving psychedelics, near-death experiences, and other instances when brain functions are diminished. This new understanding suggests that consciousness transcends the physical confines of our biological makeup, challenging conventional notions about its origin and nature.Furthermore, the book introduces a transformative perspective on the universe, proposing that what we perceive as material is merely a function of our sensory systems. Based on the author's review of current theories of the composition of the cosmos, we now know everything that exists is composed of energy, with physicality representing deeper qualities that lie out of our reach. Drawing on proven quantum physics, the author presents the theory that the universe's interconnectedness is a product of coherent quantum fields from which everything emerges and takes on the character of separateness and materiality in the 4D or manifest level we experience.In a radical departure from mainstream materialist thought, "The Signals in the Noise" argues that consciousness is a universal phenomenon occurring in varying degrees of complexity across all organisms. The author posits that while the presence of proto-consciousness is universal, the consciousness we experience emerges in the fourth-dimensional or manifest level, an idea that, if widely accepted, can redefine our understanding of life and existence.Finally, the author criticizes the materialist worldview, stating that this ingrained belief system creates many societal, political, religious, and environmental problems. He argues that our obstinate adherence to materialist orthodoxy drives our trajectory toward planetary destruction. Catalyzed by our capitalist system of consumption, this materialist belief system hinders our ability to recognize and correct the adverse effects of our actions."The Signals in the Noise" is a compelling critique of the materialist worldview, challenging our understanding of consciousness, existence, and our place in the universe. It underscores the urgency to redefine our perspectives to avert the catastrophic trajectory that our current beliefs are driving us toward. This book is a radical and thought-provoking read for anyone interested in consciousness, quantum physics, and the future of our planet.BioRobert is a member of The Institute of Noetic Sciences and engages in its activities. And in early 2023, he became a Fellow of the American Institute of Philosophical and Cultural Thought.Amazon link https://tinyurl.com/3u2sxn7uhttps://www.pastliveshypnosis.co.uk/https://www.patreon.com/ourparanormalafterlifeBecome a supporter of this podcast: https://www.spreaker.com/podcast/our-paranormal-afterlife-finding-proof-of-life-after-death--5220623/support.

References Front Cell Dev Biol. 2022; 10: 946393. Adv Exp Med Biol. 2024:1440:149-161 Mozart, WA..1786.Horn Concerto in E-flat major # 4 KV 495 https://youtu.be/MMjqU461WpI?si=o2OWIijoe-mbF-pM Sebastian, J. 1968 She's a Lady https://youtu.be/xyFdzevDOHg?si=wgmv5z_jGrtA9x7c --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

✨SPECIAL ANNOUNCEMENT✨ I've just released my newest product

Michelle Coulson is Founder and Chief Remote Rebel at Remote Rebellion whose mission is to enable people to live the life that they choose. Michelle shares her journey working around the world finding opportunities in response to economic, pandemic, and workplace changes. She explains how the COVID19 crisis gave everyone time to reflect about their life, work, and happiness. Michelle discusses reactions to being told to go back to the office--and finds meaning in launching her own venture. She questions what people settle with but could ask for and explains how to explore and navigate new remote working possibilities.     KEY TAKEAWAYS   [03:02] Michelle early love of travel guides her studies.   [04:06] 2009 is a bad year to graduate, so Michelle makes her way to Thailand via Australia.   [05:50] Michelle finds comfort and a better version of herself in Southeast Asia.   [07:15] Working as a tour guide takes its toll on Michelle's health and she turns to digital marketing.   [08:27] Planning to cycle the globe motivates Michelle to find more lucrative opportunities, she stumbles into recruitment, and a relationship.   [11:27] Catalyzed by a breakup and the pandemic, Michelle leaves London for Bali.   [12:22] A forced return to the office prompts Michelle to quit and explore what career will let her work from anywhere.   [14:14] Michelle explains the birth of Remote Rebellion.   [17:19] Recognizing “there is more to life than work,” Michelle explores what makes her happy and builds a remote community.   [20:43] After reflecting during the pandemic, many people still feel guilty to ask for more for their lives.   [21:49] Michelle dives into Remote Rebellion's mission vision and purpose.   [23:56] Remote Rebellion's clients are diverse and yet all enjoy choosing where they work.   [26:09] Jack is one client who went from fitting kitchens to SEO work!   [28:53] Building confidence is a significant part of the journey.   [30:45] What Michelle misses and hopes for the future of Remote Rebellion.   [32:46] Remote work is here to stay while growth has slowed, for now.   [34:15] Michelle is wary of some companies' reasons and parameters for their hybrid model.   [36:21] IMMEDIATE ACTION TIP: If you want a remote job, first check why you want it. If you aren't happy with your life, what would enrich your life and how can you achieve that? Remote working may not be the solution, but if you think it is, also investigate the downsides. Then experiment to see if you like it.     RESOURCES   Michelle Coulson on LinkedIn @RemoteRebellion on X Remote Rebellion on Instagram remoterebellion.com The 4 C'S Formula: Commitment Courage Capability and Confidence, by Dan Sullivan     QUOTES (edited)   “I changed and I became quite materialistic, which I hadn't been before. I bought a designer handbag, and I don't even like this stuff. What am I doing?”   “And when the call back to the office came, I was literally holding onto the post… I don't want to do this. I said, if you won't let me work remotely from here like I have been for the past year and a half, then I quit.”   “I felt like it was a rebellion because I was angry that we were being forced back into the office when we didn't need to be. We were working great. A lot of people work better when they're able to have the freedom to choose where they work from.”   “I'm not anti-hybrid. I'm anti being told and being forced when you go into the office. And a lot of hybrid companies do do that. I just think there's a lack of trust.”   “Do you not get lonely if you work remotely? If your only source of social interaction is in the office or the people you work with, maybe you need to be questioning that.”

Brought to you by Parkdalle Intelligence https://parkdalle.com/ Watch on YouTube: hhttps://youtu.be/kB8It-3aUTA Connect with Samir Azizi on LinkedIn: https://www.linkedin.com/in/samirazizi/ Follow Samir Azizi on Twitter: https://twitter.com/AdoubleZI Follow Samir Azizi on Instagram: https://www.instagram.com/adoublezi/ Join us on this enlightening episode of the Azizi Podcast as we welcome Calvin Cooper back for an engaging discussion. Dive into the world of technology, real estate, and startup culture with Cooper's unique insights. Highlights: Rapid Changes in Tech & Real Estate: Explore how the industry has transformed since our last talk, especially in the realms of crypto and startups. Calvin Cooper's Journey: From founding Rhove, a real estate fintech startup, to facing market challenges, Cooper shares his entrepreneurial path and the transitions he faced during the market downturn post-June 2022. The Importance of Mental and Spiritual Health: Hear Cooper's personal story of navigating identity, career, and health during challenging times. Current Endeavors: Learn about Cooper's current projects, including his advisory role in the Initiative for Inclusive Entrepreneurship and his involvement with Groundfloor, a real estate fintech company. World Travels and Personal Growth: Discover the insights Cooper gained from his travels and his approach to life and business post-sabbatical. Future of Real Estate & Tech: Delve into the future possibilities in real estate and technology, and how Cooper is contributing to these fields. Connect with Calvin Cooper: Find Cooper on LinkedIn to learn more about his projects and follow his journey: https://www.linkedin.com/in/calvinncooper/ Don't miss this opportunity to gain valuable insights from a visionary in the tech and real estate spheres. Whether you're an entrepreneur, investor, or just curious about the future of these industries, this episode offers a wealth of knowledge. About IIE.VC https://www.iie.vc/ In an alliance with the U.S. Treasury Department and numerous private-sector foundations, JumpStart leads the Initiative for Inclusive Entrepreneurship's (IIE) efforts to accelerate equity and inclusion across the U.S. venture capital industry. IIE's commitment includes helping diverse emerging fund managers raise $6B+ in AUM (Assets Under Management) by 2025. Catalyzed by the U.S. Treasury's State Small Business Credit Initiative's (SSBCI) $10B program, IIE's vision is to reshape the venture capital industry by dramatically increasing assets under management led by venture capital managers of color. About Groundfloor https://groundfloor.com/ Groundfloor is the first and only private real estate lending marketplace open to non-accredited investors. Before Groundfloor, only accredited investors had access to the diversification, risk-adjusted returns & control available via private market investments. Groundfloor opens the door to short-term, high-yield returns backed by real estate. We bring together individual investors looking for short-term lending investments and borrowers looking for short-term financing for their specific real estate projects. Borrowers get access to more flexible, faster and cheaper capital than a traditional bank or a hard-money lender. Investors get access to short-term, high-yield investments offering returns that average over 10%.  

Built the 500K-follower, worldwide social media and film brand, growing a global audience and achieving verified status across all social media platforms to establish Pilli as a leader in dynamic, inspiring digital branding, marketing, and film content. Captured the attention of global companies, from household names to top-tier luxury brands, partnering with market leaders across all industries to shape creative, imaginative content that inspired exceptional audience attention. Forged strong relationships between brands and social media influencers, empowering impactful collaborations and partnerships. Catalyzed brand revitalizations, won the attention and support of new, younger audiences, and spurred continuous growth, creating story-centered and inventive content to deliver world-class results. Highlights of the Episode: 0:00 Introduction0:19 Introduction of guest1:36 Andre Py's Journey to Content Creation5:01 Navigating the worlds of creator and director10:01 Success through Affiliate Marketing and Winning a Competition15:00 Racing a car against a helicopter20:01 Content Creation and the Changing World of Marketing25:00 Transitioning from traditional to creative career30:01 The importance of storytelling35:01 AI as a bridge between humans and nature40:01 Exploring Digital Technology in Visual Effects45:01 Finding the perfect location and actors for a short film50:01 Successful Short Film Pitch55:00 Preparing for a Filmmaking Pitching Session1:00:01 Andre Pilly's journey and work1:01:37 Outro Connecting with the Guest:Website: https://pilli.film/Linkedin: https://www.linkedin.com/in/andrepilli/?locale=en_US Connecting with CG Pro:Facebook: https://www.facebook.com/groups/becomecgproInstagram: https://www.instagram.com/becomecgpro/Website: https://www.becomecgpro.com/Twitter: https://twitter.com/BecomeCGPro #VirtualProduction #VisualEffects #FilmMaking

Yurok fisherman and tribal leader Sammy Gensaw and environmental scientist-turned-activist Craig Tucker share the epic story of how Indigenous leadership and non-Indian allyship made the impossible inevitable: the biggest-ever dam removal and salmon restoration in history. It represented a literal watershed moment; unprecedented co-equal decision-making between the tribes and their historical nemesis - the US government. Once complete in 2024, the project will liberate the Klamath river and several tributaries to once again run free across 400-miles from Oregon through California and into the Pacific Ocean.  Featuring Sammy Gensaw (Yurok) is the Founding Director of the Ancestral Guard, Artist, Yurok Language Speaker, Singer, Writer, Cultural/Political/Environmental Activist, Regalia Maker, Mediator, Youth Leader & Fisherman. Craig Tucker has 20+ years of advocacy and activism experience, especially working with tribal members, fishermen and farmers in the Klamath Basin on dam removal, traditional fire management, gold mining, and water policy, and is the founder and Principal of Suits and Signs Consulting Resources Indigenous Forum – Undam the Klamath! How Tribes Led the Largest River Restoration Project in US History | Bioneers 2023 This is an episode of the Bioneers: Revolution from the Heart of Nature series. Visit the radio and podcast homepage to learn more.

David Skripac discusses how his father's escape from communist Yugoslavia, his work in the field for the Canadian Forces, and his research of history led him to a proper understanding of what's going on. He discusses the global empire that is emerging and how Covid-19 was used as a catalyst to erode our individual freedoms and erase national sovereignty. The digital gulag is the endgame. He doesn't believe Putin is against the globalist agenda and that BRICS is two sides of the same coin. Watch On BitChute / Brighteon / Rokfin / Rumble / PentagonTube Geopolitics & Empire · David Skripac: A Global Empire is Emerging Catalyzed by COVID1984 #380 *Support Geopolitics & Empire! Become a Member https://geopoliticsandempire.substack.comDonate https://geopoliticsandempire.com/donationsConsult https://geopoliticsandempire.com/consultation **Visit Our Affiliates & Sponsors! Above Phone https://abovephone.com/?above=geopoliticseasyDNS (use code GEOPOLITICS for 15% off!) https://easydns.comEscape The Technocracy course (15% discount using link) https://escapethetechnocracy.com/geopoliticsPassVult https://passvult.comSociatates Civis (CitizenHR, CitizenIT, CitizenPL) https://societates-civis.comWise Wolf Gold https://www.wolfpack.gold/?ref=geopolitics Websites Moving Toward a Global Empire: Humanity Sentenced to a Unipolar Prison and a Digital Gulag https://www.globalresearch.ca/moving-toward-global-empire-humanity-sentenced-unipolar-prison-digital-gulag/5818824 Global Research author page https://www.globalresearch.ca/author/david-skripac Vaccine Choice Canada interview https://www.bitchute.com/video/DpJZseiAfhRR About David Skripac David Skripac has a Bachelor of Technology degree in Aerospace Engineering. He served as a Captain in the Canadian Forces for nine years. During his two tours of duty in the Air Force, he flew extensively in the former Yugoslavia as well as in Somalia, Rwanda, Ethiopia, and Djibouti. *Podcast intro music is from the song "The Queens Jig" by "Musicke & Mirth" from their album "Music for Two Lyra Viols": http://musicke-mirth.de/en/recordings.html (available on iTunes or Amazon)

David Skripac discusses how his father's escape from communist Yugoslavia, his work in the field for the Canadian Forces, and his research of history led him to a proper understanding of what's going on. He discusses the global empire that is emerging and how Covid-19 was used as a catalyst to erode our individual freedoms […]

Catalyzed by the drop in US CPI inflation in June, near-term recession risk has moderated and the focus has shifted closer to the market's favored scenario of a painless disinflation and economic soft landing. Amidst a broad-based rally in risky assets, commodities stand out as under-valued, under-owned, and backed by compelling fundamentals and technicals—a good entry point for a catch-up tactical allocation. The BCOM index gained 5% in July, but there is likely more where this came from. Should recessionary fears not materialize over the next six months, idiosyncratic risks leave the entire complex exposed to the upside, with the rally in BCOM extending. In order of preference, we favor natural gas, ags, oil and gold, and maintain neutral stance on base metals. Speakers: Natasha Kaneva, Global Commodities Shikha Chaturvedi, Global Commodities Gregory Shearer, Global Commodities Tracey Allen, Global Commodities This podcast was recorded on July 21, 2023. This communication is provided for information purposes only. Institutional clients can view the related report at www.jpmm.com/research/content/GPS-4462795-0 for more information; please visit www.jpmm.com/research/disclosures for important disclosures. © 2023 JPMorgan Chase & Co. All rights reserved.

It took time for the now legendary 20th-century artist to find his visual voice. A new exhibition at the Cape Ann Museum transports visitors back to a pivotal summer 100 years ago when Hopper met the woman who would become his model, muse, manager and wife: Josephine Nivison.

The AI gold rush is on. The paths to monetization are seemingly endless but the most obvious converge on making humans more productive or supercharging existing business models like search advertising or subscription licenses. Much of AI adoption in enterprise IT is hidden. Our research shows a very high overlap (around 40-60%) between AI adoption in enterprise tech and embedded AI inside software from the likes of Salesforce, ServiceNow, Workday, SAP, Oracle and other major players. But the rapid advancements of tools from AI leaders and an emerging group of independent firms is causing customers to think differently. Catalyzed by the OpenAI Microsoft partnership, organizations are rapidly trying to figure out how to apply these tools to create competitive advantage. Every firm on the planet wants to ride the AI wave. Virtually overnight, investment capital has shifted to fund early stage AI startups with much less funding required relative to previous boom cycles. In this Breaking Analysis we review ETR data to quantify the state of AI spending in the enterprise and look at the positions of several key players in the space that offer AI tools and platforms. To do so we invite Andy Thurai, CUBE contributor, VP and principal analyst at Constellation Research. Andy will help us unpack the hits and misses from this past week's Google IO conference and give us his perspectives on what it takes to catch the AI wave and avoid becoming driftwood. Constellation research hits and misses from Google IOhttps://www.constellationr.com/blog-news/google-s-generative-ai-strategy-google-io-2023-hits-and-missesRecap of Google IO announcements:https://t.co/yx6POoLRLG https://twitter.com/rowancheung/status/1656564347290746880?s=51&t=AqnHczjrru-dQaVNpPGp7wMicrosoft eyes search deal with Firefox as Bing search sputters:https://www.theinformation.com/articles/microsoft-eyes-firefox-search-deal-as-bing-chatbot-gains-sputter?rc=nxigdxWatson beats Ken Jenningshttps://www.youtube.com/watch?v=Sp4q60BsHoYIBM Watsonxhttps://www.infoworld.com/article/3695951/ibm-takes-on-aws-google-and-microsoft-with-watsonx.html

Nearly 50 years ago a Korean American immigrant named Chol Soo Lee was convicted of a murder in San Francisco's Chinatown that he did not commit. Lee spent ten years in prison after that arrest, and very possibly might have spent his whole life there if it were not for the dogged advocacy of Asian American activists who saw in his case a grave injustice born of racism and indifference. By the time of Lee's death in 2014, this movement had largely been forgotten, but a new documentary film is reviving the memories. On this edition of KCBS In Depth, we revisit a seminal moment in the history of Asian American identity with the directors behind the film, "Free Chol Soo Lee."  Guests:  Julie Ha, co-director, "Free Chol Soo Lee" Eugene Yi, co-director, "Free Chol Soo Lee"   Gail Whang, former member, Bay Area Chol Soo Lee Defense Committee  Host: Keith Menconi  Special note: The film is available to stream on the PBS YouTube channel until May 23rd and the PBS App until July 22nd.

The COVID-19 pandemic disrupted almost every sector imaginable in health care, especially pharmacy practice. Dr. Julie Cunningham, Associate Chief Pharmacy Officer of clinical practice at Mayo Clinic Midwest region, and Dr. Dmitry Walker, Assistant Director, Pharmacy Oncology in Investigational Drug Services at West Virginia University Medicine discuss stopping and starting pharmacy services due to COVID with Gretchen Brummel.   Guest speakers: Julie Cunningham, PharmD, R.Ph Associate Chief Pharmacy Officer of clinical practice  Mayo Clinic Midwest Region   Dmitry Walker, PharmD, MS Assistant Director, Pharmacy Oncology in Investigational Drug Services West Virginia University   Moderator: Gretchen Brummel, PharmD, BCPS Pharmacy Executive Director Vizient Center for Pharmacy Practice Excellence   Show Notes: [01:26-03:51] Background of Julie and Dmitry [03:52-04:47] Understanding impacts of COVID-19 on pharmacy practice [04:48-09:20] Focus of the Survey [09:21-16:05] How practices have been impacted from the beginning [16:06 -18:01] Other shifts in staffing or hiring [18:02-19:35] Challenges of pediatric RSV and influenza surge [19:36-22:49] Learning from where we've been through this process [22:50-25:48] Future predictions   Links | Resources: Infographics Vizient Pharmacy Network Tech Recruitment/Retention Pulse Survey Click here  (member link) Pharmacy technicians: the engine of health-system pharmacy Click here (member link)   Subscribe Today! Apple Podcasts Amazon Podcasts Google Podcasts Spotify Stitcher Android RSS Feed  

If you feel as if your life as you've known it is imploding and everything you once knew, loved, and identified with no longer feels aligned with who you're becoming, this one is for you. In this episode, we'll explore what it means to be spiritually catalyzed.This process of inner catalyzation is identified in a variety of ways in spiritual teachings and literature...Tower MomentDark Night of the Soul (DNOS) InitiationSpiritual Transformation Ego DeathThe Big Hairy BreakdownYet, all of these names describe the same thing: A pivotal event or experience that initiates a process of deep inner transformation. SourcesBertrand, A., & Bertrand, S. (2017). Womb awakening: Initiatory Wisdom from the Creatrix of all life*. Bear & Company.Steiner, R. (1994). How to know higher worlds*. Anthroposophic Press.Article: Materialism vs. SpiritualismArticle: Deepak Chopra on Object Referral and Self ReferralArticle: Spiritual Transformation: 9 Signs You're EvolvingContinued Reading + ResourcesHigher Self Q + A on Spiritual CatalyzationEpisode: The Ego is an Instagram FilterEpisode: The 7 Veils of IllusionArticle: 15 Symptoms of a Kundalini Awakening (and why it's so powerful)Article: What is Kundalini Awakening? (19 Intense Symptoms)*This is an affiliate link. Purchasing through affiliate links supports my work at no extra cost to you. Thank you for your support!Disclaimer: This podcast is intended for entertainment and informational purposes only and does not substitute individual psychological advice.

In this episode, host Matt Roberts of Amdocs and his co-host Liliana Schwartz-Brunner, GM and Division President North America of Telcos at Amdocs, sit down with another guest at the Mobile World Congress (MWC) 2023 in Barcelona, Spain: Debika Bhattacharya, Chief Product Officer at Verizon Business. To kick off the episode, Debika shares more information about her recent promotion, including what she's expecting from her new role. She also explains some examples of how Verizon is lending itself to tech for good initiatives by keeping people connected and offering products and services to first responders. Matt also asks Debika for her opinion on what the next big 5G use case will be, and how we can continue to foster a spirit of innovation within the tech ecosystem.This podcast episode was produced by Quill.

In this week's Live Q&A Kris and Alley answer questions about how to partner your faith with your dreams. They share on how to distinguish if your dreams are God dreams or you-dreams, how to activate your faith while you sleep, and how to partner with God for your life's purpose. You can tune in weekly on Tuesday to watch the LIVE Q&A sessions on Kris Vallotton's Instagram and Facebook. Connect with Kris Vallotton: Website: https://www.krisvallotton.com/ Facebook: https://www.facebook.com/kvministries/ Instagram: https://www.instagram.com/kvministries/ Twitter: https://twitter.com/kvministries Questions: - What are some verses I can stand on as I partner with God for my dreams? - How do you know it is a God dream and not a “you” dream? - Is there a difference between a dream in your heart and purpose/destiny? - Can faith be activated in my dreams while I'm sleeping? - Are there different mantles that rest on whole family units? - How can I partner with God in my dreams? Additional Resources by Kris Vallotton: https://shop.bethel.com/collections/kris-vallotton About Kris Vallotton: Kris Vallotton is the Senior Associate Leader of Bethel Church, Redding, and is the Co-Founder of Bethel School of Supernatural Ministry (BSSM). He is also the Founder and President of Moral Revolution and a sought-after international conference speaker. Kris and his wife, Kathy, have trained, developed, and pastored prophetic teams and supernatural schools all over the world.

Hello beautiful friend, thank you for joining me and gnostic intermediary Zachary Feltey in this spiraling conversation where we chat about being in the heart, body, and grace of this human experience. Tune into the audio-only version of the episode wherever you listen to podcasts. Download, share, follow — every expression of support helps in all the ways! Grateful for you.episode transcription available hereabout Zachary:Zachary Feltey is a meandering student of the Way, mapping his life along trajectories of auspicious interconnectedness on a journey of and for sacred belonging. Catalyzed by crisis and profound suffering in his early twenties, he has been compelled to center his life around spirituality and healing for the last decade and a half, listening longingly and desperately for "the flute of the Godhead behind the near screen of secret woodlands," as Sri Aurobindo so poetically put it. This winding journey has led from a foundation in addiction recovery, through various meditation centers, temples, and monasteries, across pan-Asian (mis)adventures, into and out of various institutions of higher learning, in concert with various spiritual traditions and a number of psycho-spiritual modalities and contexts, from indigenous ceremonies to contemporary and emergent therapeutic innovations, though the true crux has always been a fellowship of indispensably compassionate companions. Though often feeling more lost than found in this winding spiralic pilgrimage, Zach has stumbled into becoming something of a receptacle for various streams of wisdom and compassion, which he struggingly seeks to integratively gestate and birth forth as a kaleidoscopic array of holonomic visionary potentiality, as a sacred offering to a world in peril. Blog: https://reminderoflife.wordpress.com Email: zmfeltey@gmail.comabout me:I'm Pei-Ling Lee, an Energy Artist devoted to reflecting truth and shining light on the love that we are. Alongside English and Mandarin, energy is my native language. A natural communicator, I translate helpful energy into words, colors, symbols, shapes, and sounds. Through card readings and custom art, I help clients expand awareness, experience healing, and connect with their true essence.Let's Connectabout spiraling with/in:spiraling with/in is an inspiring podcast for illuminating conversations where we spiral with/in the present moment together. Tuning into whatever arises in the here and now.an open invitation:For creative and business inquiries, please send me a message to explore the alignment of collaboration.a loving disclaimer:All content offered to you through me, Pei-Ling Lee, on any channel or website is for general information and entertainment purposes only. You are your own best resource, teacher, healer, and guide — fully responsible for yourself and all of your choices, actions, experiences, and outcomes. The content I share is not intended to be considered medical, mental health, legal, financial, or religious advice. Everything is invitational, offered forth for you to discern what's true, aligned, and resonant with you now.Love, light, and blessings!

CIHT - blacklight power Fact: 1. Catalyzed hydrino transition is an electrochemical cell producing power by the reaction of hydrogen to form hydrinos. 2. The production of hydrinos results in direct electricity. 3. BlackLight process has four principle applications to motivate power: ciht, charging batteries, electrolysis to charge batteries, heat converted to electricity to charge batteries, and hybrid electric system. 4. Water has 55 moles/liter. Hydrogen to hydrino releases 50 MJ/Mole H2. One liter of water would produce 2.75 billion joules of energy. 5. A Prius consumes 9 x 10^5 J/Mile. The prius could travel 3000 miles, but most fuel cells are 50% efficient, reducing the range to 1500 miles. The onboard electrolysis unit providing the hydrogen would use 1% of the electrical output. 6. A 200 liter cell could deliver 200 kW or 267 HP and weight 200 kg that is half the weight of an internal combustion engine. --- Send in a voice message: https://anchor.fm/david-nishimoto/message

The UN Development Programme in a report says soaring inflation rates have seen an increase in the number of poor people in developing countries by 71 million in the three months since March 2022. The UNDP says an analysis of 159 developing countries globally indicates that price spikes in key commodities are already having immediate and devastating impacts on the poorest households, with clear hotspots in the Balkans, countries in the Caspian Sea region, and Sub-Saharan Africa.

Welcome to The Starting Zone Podcast, The World of Warcraft Podcast for New and Experienced Players! On this weeks episode, Spencer Downey and Jason Lucas discuss major raid tuning, Rares not being rare, Hotfixes and everything else going on around Azeroth and Shadowlands! Episode #516: Catalyzed Transmog! is ready for Download! What's New this Week in World of Warcraft! Weekly Event – Shadowlands Dungeon Event Legion M+ Affixes - Tyrannical, Bursting, Volcanic World Boss - Mortanis, the Bone Construct in Maldraxxus Guile Charm (Rogues) Fujieda (Warriors) Keefer (Monks) Desmotaeron World Boss - Mor'geth, Tormentor of the Damned Zereth Mortis World Boss - Antros Mythic + Affixes - Fortified, Raging, Explosive, Encrypted Torghast - Soulforges, Mort'regar Dungeon quests - Theater of Pain, Theater of Pain 2: Electric Boogaloo PvP quests - Arenas, Epic BGs PvP Brawl - Deepwind Dunk Darkmoon Faire - May 1st to 7th Volunteer Guard Day - April 28th Raid Tuning Update PvP Tuning ABetterABK Strike Fund and much more!   Trying to reach the show? You can find us on Discord at The Starting Zone or email us at TheStartingZone@Gmail.com Have you heard about our Patreon? It's a great way to support the show and goes towards making more content for you! Check it out here: https://www.patreon.com/thestartingzone Looking for to grab some great TSZ merch? Look no further than here! We've got the shirts, hoodies, mugs, pillows even stickers you want!

The Rise of the Operator Investor with Romeen ShethIn this week's episode, Romeen Sheth sits down with Jeremy Neilson to talk about getting allocation into the best VC deals and the rise of operator investors, running companies and investment syndicates simultaneously.As traditional funds get bigger and bigger, a new breed of venture investor has emerged — one that is increasingly attractive to founders and LPs alike. Catalyzed by tooling that empowers individual operators (or small teams) to efficiently and cost-effectively run their own investments, entrepreneurs and other operators are now seizing the chance to lead their own investment syndicates while running their companies. There are many synergies on both sides, and these operators are nimble in bringing clear, differentiated value with their capital.They bring with their capital the coveted experience, relationships, and domain expertise that can move the needle in some area of importance for a founder.For these operators, they are now enabling increased exposure as startup investors without retiring as an operator. Instead of sacrificing their value as an operator, they are finding that their investment syndicates become an invaluable asset to their role as a company builder.To learn more about Romeen Sheth and the Rise of the Operator Investor, click here.

Laura reports from “He Sapa‘', the sacred Black Hills of South Dakota where NDN Collective is reclaiming ancestral lands to address homelessness, addiction and violence against Native Americans. Catalyzed in 2020, by an action in which Land Defenders blocked former President Donald Trump's road to Mount Rushmore, this Landback campaign is about reclaiming, along with stolen land, native ceremonies, spirituality and traditions of community care. In this special feature, Laura reports on Camp Mniluzahan, a tipi village built on tribal trust land, that welcomed hundreds of unhoused Indigenous people and others in the Rapid City area in the dead of winter last year.  Laura's guests, Oglala Lakota activists Nick Tilsen, Krystal Two Bulls, Sunny Red Bear and Hermus Bettelyoun of NDN Collective. [Camp Mniluzahan] is... a teaching moment [about] what could happen. We're envisioning what could be if we actually had control of our lands and what it would mean to have land back.  -Sunny Red Bear, Director of Racial Equity, NDN Collective; Lakota from the Cheyenne River Sioux ReservationGuestsHermus Bettelyoun, Racial Equity Organizer, NDN Collective; Oglala LakotaSunny Red Bear, Director of Racial Equity, NDN Collective; LakotaAmy Sazue, Education Equity Organizer, NDN Collective; Sicangu & Oglala LakotaNick Tilsen, President & CEO, NDN Collective; Oglala LakotaKrystal Two Bulls, Director of LANDBACK Campaign, NDN Collective; Northern Cheyenne/Oglala Lakota Full episode notes including related articles and LFShow episodes to watch and/or listen to are posted at https://Patreon.com/theLFShow. Patreon Members receive access to the FULL UNCUT INTERVIEW with Sunny Red Bear from this episode.

The Cognitive Crucible is a forum that presents different perspectives and emerging thought leadership related to the information environment. The opinions expressed by guests are their own, and do not necessarily reflect the views of or endorsement by the Information Professionals Association. During this episode, Courtney Cano and Kaitlyn Tierney, who are graduate students at the Middlebury Institute of International Studies (MMIS), discuss their award-winning project: Diverting Hate. Their team studied the ways in which radicalization proliferates online–especially misogyny and involuntary celibacy (incel) culture–and developed prevention methods to help individuals build resiliency. Resources: Cognitive Crucible Podcast Episodes Mentioned #4 Tony Sgro on Education, Terrorism, and Information Operations   Middlebury Institute of International Studies (MMIS) Diverting Hate Website Diverting Hate Contest Winning Youtube Presentation 2014 Isla Vista killings Middlebury students take home top prize in national competition Link to full show notes and resources https://information-professionals.org/episode/cognitive-crucible-episode-88 Guest Bios:  Kaitlyn Tierney is a passionate leader aspiring to bridge the gaps of technology and policy through conflict resolution, innovative counterterrorism, and empathy. Inspired to take action to heal our ever-polarizing country, Kaitlyn decided to pursue her master's in policy in 2021 to connect with experts in extremism to address radicalization on social media. Previously, she spent six years in brand marketing, assisting to develop the brand of a successful personal finance technology company, Credit Karma. Aside from my career aspirations, Kaitlyn is a big believer in living life to the fullest. She finds joy in being outdoors skiing and surfing, as well as traveling this beautiful country via her Subaru Forester.  As a first-generation college student, Courtney Cano is a proud product of the public sphere and was fortunate as a child to be immersed in well-funded public schools, libraries, and after school programs. By all accounts, Courtney has made the best of public institutions to advance her station in life. However, this is by no means equally, or even similarly feasible for everyone. Whether by race, ethnicity, ability, sex, gender, economic status, or the likes, Courtney believes that all have varying degrees of privilege. As such, she has always had an interest in access and equity in both the government and society. Courtney's studies in Political Science, Religion, and Philosophy at Middlebury College were generalist and explored both the philosophical and observed aspects of governance on a national scale. After college, however, she found myself drawn towards the kind of community-building and empathetic advocacy that is necessary to address radicalization after experiencing the polarization and radicalization of her own father. Catalyzed to take action, Courtney decided to pursue her master's to explore the nexus between policy, society, and innovative counter extremism measures. About: The Information Professionals Association (IPA) is a non-profit organization dedicated to exploring the role of information activities, such as influence and cognitive security, within the national security sector and helping to bridge the divide between operations and research. Its goal is to increase interdisciplinary collaboration between scholars and practitioners and policymakers with an interest in this domain. For more information, please contact us at communications@information-professionals.org. Or, connect directly with The Cognitive Crucible podcast host, John Bicknell, on LinkedIn. Disclosure: As an Amazon Associate, 1) IPA earns from qualifying purchases, 2) IPA gets commissions for purchases made through links in this post.

The following is a conversation between Sean Doherty, the Chairman of the JDRF Type 1 Diabetes Fund, and Denver Frederick, the Host of The Business of Giving. In 2015, a group of JDRF volunteers, formerly known as the Juvenile Diabetes Research Foundation, observed that there was virtually no private investment in type 1 diabetes, which was causing a gap between scientific advancements and the delivery of solutions to the people who need them. Their solution: launch the JDRF T1D Fund, a venture philanthropy fund to create a market in T1D by using their capital and expertise to convince venture capital, biotech, and pharma to make the investments needed to cure type 1 diabetes. And here to tell us about how this work is going is Sean Doherty, the chairman of the T1D Fund.

Catalyzed by a Ryan Breslow viral tweetstorm, we break down the arguments for if companies should loan money to employees to allow them to exercise their stock options early (1:42). Then, we briefly cover Nvidia's attempted Arm acquisition falling through and what it might mean for the SoftBank-owned chip designer (30:21). Finally, Molly interviews Craig Zingerline from Growth University, a LAUNCH Accelerator founder (38:00)! (0:00) Jason and Molly tee up today's topics: Bolt CEO strikes again, Nvidia's failed Arm acquisition, interview with LAUNCH Accelerator Cohort 24 founder Craig Zingerline (1:42) Jason breaks down employee stock options and how equity works at early-stage startups (10:29) OpenPhone - Get an extra 20% off any plan for your first 6 months at https://openphone.com/twist (11:27) How has Bolt CEO Ryan Breslow changed equity options for his employees? Is this new model smart or way too risky? (21:19) RealGoodFoods - Go to https://realgoodfoods.com and use code TWIST for $15 off! (22:41) VC response to Bolt's new stock option plan, Jason's final thoughts (30:21) Nvidia's failed acquisition of Arm, is this another SoftBank flop? (35:21) Teeing up the Craig Zingerline interview (36:50) Ourcrowd - Check out the deal of the week at https://ourcrowd.com/twist (38:00) Molly interview current LAUNCH Accelerator portfolio founder Craig Zingerline about his startup Growth University Check out Growth University: https://growthuniversity.io/ FOLLOW Craig: https://twitter.com/craigzingerline FOLLOW Jason: https://linktr.ee/calacanis FOLLOW Molly: https://twitter.com/mollywood Ryan Breslow's Tweet in Question: https://twitter.com/theryanking/status/1493390167461224451

Catalyzed by a Ryan Breslow viral tweetstorm, we break down the arguments for if companies should loan money to employees to allow them to exercise their stock options early (1:42). Then, we briefly cover Nvidia's attempted Arm acquisition falling through and what it might mean for the SoftBank-backed chip designer (30:21). Finally, Molly interviews Craig Zingerline from Growth University, a LAUNCH Accelerator founder (38:00)!

Today I am thrilled to be sharing a full episode from my all new Conversations with CommerceNext podcast featuring Jon Mandell, Senior Vice President of Global Membership Marketing and Commerce with WW.  WW started their digital transformation long before the pandemic demanded brands to keep up with the great acceleration of eCommerce, and on this episode along with my co-host Scott Silverman  we get an inside look at the process and people behind WW's great leap forward and how the groundwork laid in the past is preparing them for future success.Jon walks us through the overall process and strategy behind the transition, and how the pandemic changed the game.  We ask Jon about his career, what he looks for when building a resilient team, and advice that he would give his past self.To discover career opportunities with WW click here. I launched the Conversations with CommerceNext podcast with my U.S. based partners to meet the top practitioners and thought leaders in the DTC & eCommerce marketing space, and explore both their tradecraft and share the learnings from their career journeys.  Let's listen in now as Scott kicks off our conversation. Thanks for tuning into this episode of Conversations with CommerceNext.  Please follow us on Apple, Spotify, Amazon Music or your favorite podcast platform where we'll be sharing career advice and marketing strategies from eCommerce and digital marketing leaders at retailers and direct-to-consumer brands each and every episode.   CommerceNext is a community, event series and conference for marketers at retail and direct-to-consumer brands. Through our online forums, interviews, webinars, summits and other in-person events, we harness the collective wisdom of our community to help marketers grow their businesses and advance their careers. Join CommerceNext events to meet other industry leaders and learn the latest ecommerce and marketing strategies. You can find upcoming events at CommerceNext.com Jon MandellSVP, CXO, C-suite Leader → Brand Transformation Catalyst → Customer Engagement StrategistBuilding, leading, and optimizing customer-centric organizations to drive growth and revenue has been the hallmark of my career. I leverage strategy, technology, operational excellence, and innovation to shape unique customer experiences that deliver value and engender customer engagement, loyalty, and retention. I excel in identifying business growth opportunities in organizations and developing them into impactful business drivers to increase revenue, income and previously untapped value.My experience spans executive leadership roles (transformations, growth initiatives, M&A, turnarounds, and integrations) with leading public companies (WW & 1-800-Flowers.com), co-founder/COO/MD of 2 technology startups, operations and general management roles, and an early career with AT&T Wireless. As a leader, I am best known for expanding the vision for what is possible and forming cohesive, motivated teams to drive organizational growth boldly and systematically from the ground up.CAREER MILESTONES

Welcome to the Conversations with CommerceNext podcast, I'm your host Michael LeBlanc, and this podcast is brought to you in conjunction with CommerceNext and presented by Bloomreach. WW started their digital transformation long before the pandemic demanded brands to keep up with the great acceleration of eCommerce. Today on the Conversations with CommerceNext podcast, get an inside look at the process and people behind WW's great leap forward and how the groundwork laid in the past is preparing them for future success.Scott Silverman and I talk to one of the great minds behind this major moment in WW history - Jon Mandell, Senior Vice President of Global Membership Marketing and Commerce.Jon walks us through the overall process and strategy behind the transition, and how the pandemic changed the game.  We ask Jon about his career, what he looks for when building a resilient team, and advice that he would give his past self.To discover career opportunities with WW click here. Thanks for tuning into this episode of Conversations with CommerceNext.  Please follow us on Apple, Spotify, Amazon Music or your favorite podcast platform where we'll be sharing career advice and marketing strategies from eCommerce and digital marketing leaders at retailers and direct-to-consumer brands each and every episode.   CommerceNext is a community, event series and conference for marketers at retail and direct-to-consumer brands. Through our online forums, interviews, webinars, summits and other in-person events, we harness the collective wisdom of our community to help marketers grow their businesses and advance their careers. Join CommerceNext events to meet other industry leaders and learn the latest ecommerce and marketing strategies. You can find upcoming events at CommerceNext.com Jon MandellSVP, CXO, C-suite Leader → Brand Transformation Catalyst → Customer Engagement StrategistBuilding, leading, and optimizing customer-centric organizations to drive growth and revenue has been the hallmark of my career. I leverage strategy, technology, operational excellence, and innovation to shape unique customer experiences that deliver value and engender customer engagement, loyalty, and retention. I excel in identifying business growth opportunities in organizations and developing them into impactful business drivers to increase revenue, income and previously untapped value.My experience spans executive leadership roles (transformations, growth initiatives, M&A, turnarounds, and integrations) with leading public companies (WW & 1-800-Flowers.com), co-founder/COO/MD of 2 technology startups, operations and general management roles, and an early career with AT&T Wireless. As a leader, I am best known for expanding the vision for what is possible and forming cohesive, motivated teams to drive organizational growth boldly and systematically from the ground up.CAREER MILESTONES

Call unto me and I will answer thee and show thee great and mighty things which thou knowest not

The following audio exclusive  features the entire uncut interview with NDN Collective's Director of Racial Equity, Sunny Red Bear of the Lakota Nation.  Excerpts of this interview were included in our recent special  “LANDBACK! A Tipi Town Approach to Healing & Homelessness”.   In this special feature, Laura traveled to the sacred Black Hills of South Dakota where NDN Collective is reclaiming ancestral lands to address homelessness, addiction and violence against Native Americans.  Laura reported on  Camp Mniluzahan, a tipi village built on tribal trust land, that welcomed hundreds of unhoused Indigenous people and others in the Rapid City area in the dead of winter last year.   Catalyzed in 2020, by an action in which Land Defenders blocked former President Donald Trump's road to Mount Rushmore, this Landback campaign is about reclaiming, along with stolen land, native ceremonies, spirituality and traditions of community care. If you're a listener or a viewer, you spend time with us. Many of you have for years. So how about taking a few minutes to give us the support we need to keep doing what we do… Only a few minutes from you, pledging $3 or $5 or $12 a month, will keep us going all year. Go to Patreon.com/theLFShow and join our media team and support movement building.  Thanks!

Check out the full episode notes, along with an invitation to join guests from the episode with Laura for a live premiere and chat event to view this week's episode via our YouTube channel, Sundays 11:30am EDT, at Patreon.com/theLFShow  On Indigenous Peoples' Day, Laura reports from “He Sapa‘', the sacred Black Hills of South Dakota where NDN Collective is reclaiming ancestral lands to address homelessness, addiction and violence against Native Americans. Catalyzed in 2020, by an action in which Land Defenders blocked former President Donald Trump's road to Mount Rushmore, this Landback campaign is about reclaiming, along with stolen land, native ceremonies, spirituality and traditions of community care. In this special feature, Laura reports on Camp Mniluzahan, a tipi village built on tribal trust land, that welcomed hundreds of unhoused Indigenous people and others in the Rapid City area in the dead of winter last year.  Laura's guests, Oglala Lakota activists Nick Tilsen, Krystal Two Bulls, Sunny Red Bear and Hermus Bettelyoun of NDN Collective.  Music in the Middle:  “Stadium Pow Wow” by A Tribe Called Red featuring Black Bear from their album We Are the Halluci-Nation, released on Radicalized Records.[Camp Mniluzahan] is... a teaching moment [about] what could happen. We're envisioning what could be if we actually had control of our lands and what it would mean to have land back.-Sunny Red Bear, Director of Racial Equity, NDN Collective; Lakota from the Cheyenne River Sioux Reservation GuestsHermus Bettelyoun, Racial Equity Organizer, NDN Collective; Oglala LakotaSunny Red Bear, Director of Racial Equity, NDN Collective; LakotaAmy Sazue, Education Equity Organizer, NDN Collective; Sicangu & Oglala LakotaNick Tilsen, President & CEO, NDN Collective; Oglala LakotaKrystal Two Bulls, Director of LANDBACK Campaign, NDN Collective; Northern Cheyenne/Oglala Lakota If you're a listener or a viewer, you spend time with us. Many of you have for years. So how about taking a few minutes to give us the support we need to keep doing what we do… Only a few minutes from you, pledging $3 or $5 or $11 a month, will keep us going all year. Go to Patreon.com/theLFShow and join our media team and support movement building. Thanks!

In this episode, Gaurav Batra, EY Global Advanced Manufacturing & Mobility Analyst Leader, discusses the findings of the latest EY Mobility Consumer Index (MCI) wave 2 research. Almost 41% of those looking to buy a car are considering buying an electric vehicle (EV). The EV sales boom is a part of a wider resurgence in car buying. Catalyzed by nonwork-related journeys and coupled with concerns over the safety of public transport, cars are considered a safer and more convenient choice for travel even as the pandemic risk declines in many countries. Though the prospect of an EV sales boom is good news, overcoming concerns over the cost and performance of EVs will be a challenge for automakers. Key takeaways: There is a shift in the type of travel being undertaken and the modal choices. While nonwork-related travel is set to recover globally, work travel intentions remain in the slow lane. Sales of all kinds of cars, EVs and internal combustion engines (ICEs) are expected to rise. For the first time, environmental concerns are topping the list of reasons for considering an EV across all age groups. Cars (in various forms) remain the safest and most convenient form of travel over public transportation, even as the pandemic risk declines in many countries.

Tarun Chitra is co-founder of Gauntlet, a financial modeling platform for crypto. Tarun is a thought leader in the space and is an expert in a variety of topics surrounding DeFi. This week, we discuss the history of electronic markets, and how we're in the third wave of this phenomenon. Get this episode's exclusive debrief!

Charcot-Marie Tooth disease is a rare, genetic nerve condition that affects 150,000 Americans and nearly 3 million people around the world. Though the condition was first medically recognized in 1886, it is without an approved therapy. The CMT Research Foundation has been seeking to change that by addressing barriers to the development of therapies for CMT. We spoke to Susan Ruediger, founder and CEO of CMT Research Foundation, about its efforts to catalyze drug development for CMT, what it's done to address obstacles, and some of the partnerships it has established to advance the development of treatments and potentially a cure.

Catalyzed from not being able to pay for tuition in Switzerland because he recently immigrated from India, Prashanth set out create a solution to Send/Receive Euros instantly via Bitcoin Send/Receive Bitcoin on-chain or on Lightning We also discuss the Berkeley Skydeck Accelerator and virtual Y Combinator experience. Check them out at lastbit.io Sign up for our newsletter featuring new insights on startups/entrepreneurship at startupmindsets.com/blog --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/startupmindsets/support

What happens when the vision crystalizes and we realize that what we remember...what has helped us make decisions that our future now depends on...is not the whole story, much less the whole truth? Can we change it? And if so, how? And why should we? My dear friend recently helped me access the most profound, shiver-worthy message that sent me back into the past so that I could re-experience it, so that I could see what I couldn't see the first time - so that I could scoop the new energy, and recapitulate the timeline between then and now... When, in 2017, I battled a whole array of conflicting emotions that I did not quite understand, a particular scene of Moana pierced my heart! It has accurately articulated what I had been experiencing; it solidified into a masterfully visual form the homesickness, the unresolved issues in my relationships, the feeling of having outgrown our space and the roles expected to play. 

It was the ancestral calling. And, it was the grieving of my old self as the process of the emergence of the new-me was just about to begin. When, in 2018, my daughters and I embarked on our 4-month Slovenian adventure, the only awareness I had, was to slow down. To heal. To reconnect. And when we returned, I experienced another dark night of the soul; I felt I no longer belonged to our home, into our union. I felt like a wild cheetah now caged and confined to a small patch of artificial grass - ready to break out. By the time 2020 pressed pause on our lives and the world seemingly stopped spinning, and the collective was filled with anger and sadness and resentment and haterage... I saw a glimpse of hope. I felt at peace. And, I felt courage. Courage to let the new me emerge: Catalyzed by awareness. Powerful in convictions. Rooted in deep knowing. In ownership of divine gifts. 

And ready to begin working on Legacy book. As words kept pouring out and on the paper, as new memories kept emerging, and pages kept being written, time has come to change the narrative. To intentionally deepen it until it feels light again - until it feel true. It was time to revisit the past... In today's journey, I also walk you through the process of making some of the most difficult decisions as a woman, wife, mom; the experience of having the most uncomfortable conversations with loved ones; the tunnel vision when advocating for oneself with no tangible or measurable proof other than the gut feeling.

WUNC's Will Michaels examines how an early morning fire in Chapel Hill on May 12, 1996 changed the trajectory of dozens of lives and became a catalyst for change in fire safety ordinances across the country.

This solo episode touches on my personal spiritual transformation, unlearning religious programming, the role psychedelics played and the inspiring teachers that helped awaken me and expand my consciousness. // STAY IN TOUCH // Instagram | @kristinabakrevski // Twitter | @kristinabaky // Website | www.kristinabakrevski.com // SHOW SOME LOVE // paypal.me/KristinaBakrevski

Today, we're talking with Anya Schiess, Co-founder and General Partner of Healthy Ventures. She will shed light on a variety of topics such as challenges for health systems, why modern data architecture is important, FinTech, and what is on the horizon for healthcare.

How much will 'futuristic' workplace trends which were catalyzed by the pandemic survive into 2021 and beyond? To what extent is the pandemic-induced regime of remote work, flexible hours and AI-enabled software here to stay? Howie Lim speaks to Dan Schawbel from Workplace Intelligence to find out. He's also a NY Times bestselling author.  See omnystudio.com/listener for privacy information.

In this weeks episode, I sit down and chat with recording artist out of Hollywood, California, one half of the "Swamp Gang" Wild The Coyote! Funny little story about this guest, I actually met him while I was at a Yelawolf concert in London, Ontario back in 2019! Him and BADD Wolf opened up for him while on his Canadian leg of the tour! Wild the Coyote used to be apart of a hard rock band, before embarking on a solo career! He is such a humbled and down to earth dude, who would give the shirt off his back to anyone! We talk about his love for music starting at such a young age, growing up in wine country in California! His real love for music really started when Green Days Dookie album came out back in the early 90s! He really wanted to be like Billy Joe Armstrong! He is now a very successful solo artist with many great songs in his library! My most favourite to date is Old Man! Credit submithub.com for the below words Wild the Coyote is a folk-rock musician who blurs the lines of genres and reimagines traditional forms of performance and storytelling. From the small country town of Templeton on California's central coast, his influences range from country legend Johnny Cash, Puddles Pity Party, & Yelawolf. In Summer 2017 he debuted new single and video for “The Boondocks,” from upcoming EP “The Phantom and the Black Crow,” which will showcase his newest blend of sounds including country, trip hop, and blues. Wild the Coyote's live show is a captivating experience full of Wild West inspired antics and gloom. In 2016, he sold out venues such as the world-renowned Viper Room on the Sunset Strip, and held multiple residencies, most recently at Hollywood's famous Hotel Cafe. Catalyzed by his 2016 release of "The Man on Top of the Hill" and "The Hollow Woods" featured on his Pandora station and YouTube channel, Wild the Coyote has garnered a loyal following in LA and beyond, as well as a significant online fan base. This podcast is brought to you by my sponsor Compass 9 Media your podcast branding specialist! The intro is provided by recording artist John Maksym, it is a clip from his single "Blame" you can follow him on Instagram @johnmaksymmusic You can follow the show on IG @depthsofdarkside or contact me by email depthsofdarkside@gmail.com --- Send in a voice message: https://anchor.fm/lightofsuccess/message

The 6 wants to bring growth, healing, and love into the ecosystem of your life. But as always, the Universe, or what I call the Zero Point Field, needs your participation if you want to receive these gifts. In this month's forecast learn: A perspective/mindset shift that you need to make, so you can see [...]

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.22.350777v1?rss=1 Authors: McCormick, J. W., Ammerman, L., Chen, G., Vogel, P. D., Wise, J. G. Abstract: P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer's disease (AD). However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-{beta} (A{beta}) protein have produced contradictory results. Here we use molecular dynamics (MD) simulations, transport substrate accumulation studies in cell culture, and biochemical activity assays to show that P-gp actively transports A{beta}. We observed transport of A{beta}40 and A{beta}42 monomers by P-gp in explicit MD simulations of a putative catalytic cycle. In in vitro assays with P-gp overexpressing cells, we observed enhanced accumulation of fluorescently labeled A{beta}42 in the presence of Tariquidar, a potent P-gp inhibitor. We also showed that A{beta}42 stimulated the ATP hydrolysis activity of isolated P-gp in nanodiscs. Our findings expand the substrate profile of P-gp, and suggest that P-gp may contribute to the onset and progression of AD. Copy rights belong to original authors. Visit the link for more info

The second of a fascinating two-part discussion, this episode delves deeper into Ming Peiffer’s Usual Girls. The play premiered in 2018 at Roundabout Underground for an extended, sold-out run. Catalyzed by the allegations against American Apparel’s Dov Charney, playwright Peiffer began to investigate the stories of women and the milestones in the sexual maturation of girls in America that can lead to a fraught and vulnerable relationship to one’s own sexuality. Peiffer put the patriarchy, rape culture, sexism, misogyny, and racism on trial in her professional debut work. What does healthy sexual development look like? How can femmes claim (or reclaim) their own sexuality? Is it possible to shed the culturally imposed shame and guilt and adopt an outlook of pleasure? What should effective sex education teach and when? What sexual stereotypes do we impose upon different communities, be it Black, Latinx, Asian, and how do we counter them? What are the consequences of teaching abstinence-only, medically inaccurate, or emotionally devoid sex ed? Peiffer, host Ruthie Fierberg, and experts Dr. Tracie Gilbert, a sex educator, writer, researcher, and consultant with over 25 years experience, specializing in work with Black communities; Professor Lisa Speidel, assistant professor and general faculty in the Gender and Sexuality department at the University of Virginia, and editor of The Edge of Sex; Professor Celine Parrenas Shimizu, Director of the School of Cinema, member of the graduate faculty of Sexuality Studies at San Francisco State University, filmmaker, and author; and Justine Ang Fonte, a disruptor in health education and Director of Health and Wellness at an NYC K-12 school, gather to discuss everything from pleasure to self-discovery, recovering from violence to self-defense and all the coming-of-age in between. Referred to in this episode Meet Ericka Hart Consent outside of sex The stats on sexual assault and rape CDC’s 16 critical topics in high school sex ed Music video: WAP Create the change Read Pleasure Activism by Adrienne Maree Brown Check out K-12 sex education resources from Advocates for Youth How to teach consent to kids at every age Practice enthusiastic collaborative consent Learn to set safe sexual boundaries Lesson Plan: How to teach accurate reproductive anatomy and physiology to kids Explore your own pleasure at stores geared towards female pleasure like Babeland or The Smitten Kitten Learn to know thyself from Audre Lorde Watch the documentary On The Record  Why We Theater is a product of part of the Broadway Podcast Network, edited by Derek Gunther, and produced by Alan Seales.  Follow us @whywetheater on Instagram & Twitter. Our theme music is by Benjamin Velez. Hear more at BenjaminVelez.com. Our logo is by Christina Minopoli. See more at MinopoliDesign.com. Special thanks to Genesis Johnson, Dori Berinstein, Leigh Silverman, Patrick Taylor, Tony Montenieri, Elena Mayer, Wesley Birdsall, and Suzanne Chipkin. Connect with Ruthie! RuthieFierberg.com Instagram: @ruthiefierceberg Twitter: @RuthiesATrain Learn more about your ad choices. Visit megaphone.fm/adchoices

The first of a critical two-part discussion, this episode focuses on Ming Peiffer’s Usual Girls. The play premiered in 2018 at Roundabout Underground for an extended, sold-out run. Catalyzed by the allegations against American Apparel’s Dov Charney, playwright Peiffer began to investigate the stories of women and the milestones in the sexual maturation of girls in America that can lead to a fraught and vulnerable relationship to one’s own sexuality. Peiffer put the patriarchy, rape culture, sexism, misogyny, and racism on trial in her professional debut work. What does healthy sexual development look like? How can femmes claim (or reclaim) their own sexuality? Is it possible to shed the culturally imposed shame and guilt and adopt an outlook of pleasure? What should effective sex education teach and when? What sexual stereotypes do we impose upon different communities, be it Black, Latinx, Asian, and how do we counter them? What are the consequences of teaching abstinence-only, medically inaccurate, or emotionally devoid sex ed? Peiffer, host Ruthie Fierberg, and experts Dr. Tracie Gilbert, a sex educator, writer, researcher, and consultant with over 25 years experience, specializing in work with Black communities; Professor Lisa Speidel, assistant professor and general faculty in the Gender and Sexuality department at the University of Virginia, and editor of The Edge of Sex; Professor Celine Parrenas Shimizu, Director of the School of Cinema, member of the graduate faculty of Sexuality Studies at San Francisco State University, filmmaker, and author; and Justine Ang Fonte, a disruptor in health education and Director of Health and Wellness at an NYC K-12 school, gather to discuss everything from pleasure to self-discovery, recovering from violence to self-defense and all the coming-of-age in between. Referred to in this episode Kinsey Institute What is a “comfort woman”? Who gets the most right-swipes on dating apps? Sexual stereotypes of Black communities and Asian communities Lesson Plan: How to teach accurate reproductive anatomy and physiology to kids Only 15 of 50 states required to be medically accurate; and other sex ed laws What is rape culture? As explained by Marshall University or Buzzfeed Children’s Book: Sex is a Funny Word Music video: WAP Create the change Check out K-12 sex education resources from Advocates for Youth How to teach consent to kids at every age Explore your own pleasure at stores geared towards female pleasure like Babeland or The Smitten Kitten Watch Justine Fonte’s “Story” Read Emily Nagoski’s Come As You Are Read Celine Parrenas Shimizu’s The Hypersexuality of Race: Performing Asian American Women on Screen and Scene Read Shimizu’s The Feminist Porn Book: The Politics of Producing Pleasure Read Lisa Spiedel’s The Edge of Sex: Navigating aa Sexually Confusing Culture From the Margins  Why We Theater is a product of part of the Broadway Podcast Network, edited by Derek Gunther, and produced by Alan Seales.  Follow us @whywetheater on Instagram & Twitter. Our theme music is by Benjamin Velez. Hear more at BenjaminVelez.com. Our logo is by Christina Minopoli. See more at MinopoliDesign.com. Special thanks to Genesis Johnson, Dori Berinstein, Leigh Silverman, Patrick Taylor, Tony Montenieri, Elena Mayer, Wesley Birdsall, and Suzanne Chipkin. Connect with Ruthie! RuthieFierberg.com Instagram: @ruthiefierceberg Twitter: @RuthiesATrain Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.04.283184v1?rss=1 Authors: Banterle, N., Nievergelt, A. P., de Buhr, S., Hatzopoulos, G. N., Brillard, C., Andany, S., Hübscher, T., Sorgenfrei, F., Schwarz, U. S., Gräter, F., Fantner, G. E., Gönczy, P. Abstract: Discovering the physical principles directing organelle assembly is a fundamental pursuit in biology. Centrioles are evolutionarily conserved organelles with a 9-fold rotational symmetry of chiral microtubules imparted onto the cilia they template. Centriole assemble from likewise symmetrical ring polymers of SAS-6 proteins, orthogonal to a toroidal surface surrounding the resident centriole. How surface properties ensure ring assembly with proper symmetry and orthogonal arrangement is not known. Here, we deployed photothermally-actuated off-resonance tapping high-speed atomic force microscopy (PORT-HS-AFM) to decipher physical principles of surface-guided SAS-6 self-assembly. Using machine learning to quantify the polymerization reaction and developing a coagulation-fragmentation model, we discovered that the surface shifts the reaction equilibrium by ~104 compared to the solution situation, explaining orthogonal organelle emergence. Moreover, molecular dynamics and PORT-HS-AFM revealed that the surface converts helical SAS-6 polymers into 9-fold ring polymers with residual asymmetry, which may impart chiral features to centrioles and cilia. Overall, we discovered two fundamental physical principles directing robust centriole organelle assembly. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.01.278481v1?rss=1 Authors: Koloteva-Levine, N., Marchante, R., Purton, T. J., Hiscock, J. R., Tuite, M. F., Xue, W.-F. Abstract: Amyloid seeds are nanometre-sized protein particles that accelerate amyloid assembly, as well as propagate and transmit the amyloid protein conformation associated with a wide range of protein misfolding diseases. However, seeded amyloid growth through templated elongation at fibril ends cannot explain the full range of molecular behaviours observed during cross-seeded formation of amyloid by heterologous seeds. Here, we demonstrate that amyloid seeds can accelerate amyloid formation via a surface catalysis mechanism without propagating the specific amyloid conformation associated with the seeds. This type of seeding mechanism is demonstrated through quantitative characterisation of the cross-seeded assembly reactions involving two non-homologous and unrelated proteins: the human A{beta}42 peptide and the yeast prion-forming protein Sup35NM. Our results suggest experimental approaches to differentiate seeding by templated elongation from non-templated amyloid seeding, and rationalise the molecular mechanism of the cross-seeding phenomenon as a manifestation of the aberrant surface activities presented by amyloid seeds as nanoparticles. Copy rights belong to original authors. Visit the link for more info

Today’s episode is one of my favorites, you guys! I brought on Pilar Holland and we talked all things women empowerment, being raised by a single mother, Pilar’s performance in The Vagina Monologues, and being surrounded by other powerhouse women. If you’re ready to tune into your higher vibes, step into loving yourself fully, and define success on your own terms, you won’t want to miss this episode.    Here’s a closer look at what we talked about: Connecting with your higher-self will allow you to vibrate at a higher frequency [08:58]  The reason why women should support each other [11:48] Loving yourself is the first step to loving others [13:23] Supporting yourself journey is just as important as providing support [16:44] Your success doesn’t have to look exactly like someone else’s [24:18]   Links we mentioned: LA Happy  A Marriage Story  @PilarHolland

It's easy to look at our daily lives to evaluate what we're doing as individuals. In today's episode, we're getting introspective and talking about our influence from another person's perspective.

I wonder how much might continue to change if I make a ritual out of listening to this recording every Monday

Do you feel like you’re doing everything? You probably are. Now is the time to change it. Me to We: It is an all-too-common reality that pastors feel buried by too much to do and often pulled in too many directions. The pastor-centric congregation is a formula for continuing this dynamic. This Pastor Resource Call identifies the telltale signs of this style of leadership and suggests practical ways to develop shared ownership of the vision and workload. We'll focus on practical ways to move from Me to We, developing people and avoiding burnout. Alan E. Nelson, Ed.D., practiced leadership as a pastor the first 20 years of his life. After earning a doctorate in the field, writing books and teaching seminary courses, he hit midlife. Catalyzed by a conversation with futurist, George Barna, Nelson moved from pastoring to becoming a social entrepreneur. The last decade he's focused on studying the gift of leadership in the very young (ages 3-23), for the purpose of getting to leaders while they're moldable, not moldy (www.LeadYoungTraining.com). He also teaches leadership at USC Marshall School of Business and the Naval Postgraduate School. Alan lives with his wife of 38 years (Nancy), in Thousand Oaks, CA.

Today, we knock on the door of James Serpell, the Marie A. Moore Professor of Ethics & Animal Welfare at the School Veterinary Medicine and the Director of the Center for the Interaction of Animals in Society. Serpell studies behavioral phenotypes of dogs and cats, a specialty study in the world of veterinary medicine as veterinary behavior itself is a rare expertise to have, with only about 70 veterinarians board certified in the specialty in the United States. Serpell works to broaden access to that well of knowledge while deepening our understanding of our companion's behaviors. Here, Serpell discusses the origins of his interest in animal behavior starting with a parrot and what he's working on right now; plus, his knack for cooking, an odd interaction during a behavior consult involving a dog and a TV, and why we can all stand to be a little less idealistic.

This icon shares the story behind his accidental role in shaping the streetwear industry from a sub-culture into luxury and pop-culture. How he created Reed Space into one of the first multi purpose experiential stores the retail industry had experienced. We go into an important unprecedented legal issue involving American Eagle, Urban Necessities (reseller), Nike, and Staple Designs...which is happening now. Will we see a legislative change in how IP and brand marks can be leveraged through buyouts and collaborations? If you'd like to receive invitations to our live recording event experiences, apply for access at www.BellwetherCulture.com

Leila & Marek: https://soundcloud.com/leilanmarek Leila and Marek both discovered their love for house music at a young age. Catalyzed by a rapidly evolving, underground Toronto music scene, their experimentation with sound began. Their trademark; a melange of soul and emotion that flows effortlessly thanks to their chemistry behind the decks. Having developed relationships with other unique artists such as Eduardo Castillo, Tone of Arc, Nature of Music and Alberto Jossue, has granted them a special opportunity to evolve their sound through a rich and diverse tapestry of artistic talent. ▲▲▲ Secret Society Sessions is a show broadcasted live every Wednesday 6-9pm. Our goal is to provide the atmosphere for a regular gathering that revolves around our love for music and the celebration of getting over the hump of the week. Come early, spend a few hours with your friends listening to artistically curated sounds and go home happy, proving that a night out does not have to be followed by a day in. This is more than a radio show… it is a social collective for people at play. We invite you for after work drinks, food and games! See you there. ▲▲▲

Rise of Doom-Catalyzed by Only Metalcore

Most churches are over-managed and under-led. They often find themselves drowning in unnecessary meetings or stuck in “business as usual” mode. Romans 12:8 says, “If your gift is leadership, then lead with diligence.” Most pastors are ministry managers, teachers and counselors, but not gifted in leadership. That's okay, but how can they tap those gifted in leadership within their congregations? This Pastors Resource Call focuses on leading, ways to identify the gift, practical steps to unleash it responsibly, and why it is essential to the Church, whether pastors possess it or not. Alan E. Nelson, Ed.D., practiced leadership as a pastor the first 20 years of his life. After earning a doctorate in the field, writing books and teaching seminary courses, he hit midlife. Catalyzed by a conversation with futurist, George Barna, Nelson moved from pastoring to social entrepreneurism. The last decade he's focused on studying the gift of leadership in the very young (ages 3-23), for the purpose of getting to leaders while they're moldable, not moldy (www.LeadYoungTraining.com). He also teaches leadership at USC Marshall School of Business and the Naval Postgraduate School. Alan lives with his wife of 36 years (Nancy), in Thousand Oaks, CA.

Rachel Carson was a writer, environmentalist, marine scientist and a cat person. She was in part responsible for the formation of the EPA- America's Environmental Protection Agency, Earth Day, The Environmental Species Act and the Clean Water Act. As if that wasn't enough she's also credited with a catalyzing the modern environmental movement. And unfortunately, also the counter-movement. She did all this through her book Silent Spring.

Communication is the foundation of a healthy relationship, and starting your own business comes with all sorts of challenges, one of the biggest being getting your spouse on board. Stepping out of the security that comes from a predictable salary, not to mention health insurance is a recipe for conflict. Today's guest, Jessica Rodriguez shares […] The post Episode 072: How Starting a Business Catalyzed Our Communication | Jessica Rodriguez appeared first on Legendary Marriage: Build a life, a love, and a legacy together..

This month diverse women are sharing their experiences as sexual assault survivors, with the hashtag #metoo. Catalyzed in part by the predatory actions of Harvey Weinstein and other powerful men, people are courageously speaking out for justice. Both sex and money are taboo topics to discuss publicly, and this shame feeds people’s control over one […]

Greetings Friends, Note: All viewers of this podcast you can help me in my philanthropy efforts by buying my book The Modern Mughal Mentality and it is available worldwide wherever books are sold. As I have pledged in the book also that certain part of my book sales would go towards philanthropy. Here is the Amazon link of my book: https://www.amazon.com/s/ref=nb_sb_noss_1?url=search-alias%3Daps&field-keywords=the+modern+mughal+mentality My participation in AMU World Alumni Summit 2015 through Video conferencing,Please see this video podcast and get inspired to do more philanthropy. Here is some more information about my philanthropy event that created a revolution at AMU,Aligarh UP,India and press in India has been writing about it: My philanthropy efforts recently created a revolution at my AlmaMater in India the prestigious Aligarh Muslim University(AMU), A very famous newspaper in India ,The Indian Express wrote a special story on it and here is the link: http://indianexpress.com/article/cities/lucknow/windfall-for-amu-gets-rs-70-lakh-from-alumni-jewellery-for-museum-on-founders-day/ My Blog post about this which I wrote earlier: http://www.afshanhashmi.com/the_modern_mughal_mentality_blog1/philanthropy_is_a_hallmark_of_my_dna I feel so proud of myself that God Almighty made me to do this noble work. Also my noble and famous family royal lineage and their training as my maternal grandfather Prof. Abdul Aleem created revolution in India during the freedom struggle by his writings. My father Prof.Majid Siddiqi created revolution also in India at AMU by founding new Biochemistry department and faculty at Life sciences at AMU as well as my mom founded a philanthropy center for underprivlged especially for Women Empowerment at AMU the famous Ismat Literacy and Handicrafts center. I live a very simple life in USA and have only one desire to donate as much as I can. You donot have to be rich to donate it is a mind set.I am trying to emulate the lives of my three mentors. To know more about my these three mentors please go to my website: http://drafshanhashmi.com/id19.html I want to make a positive change in the world through my writings and linking philanthropy to it. Certain part of my book sales would go towards my philanthropy efforts and I have many philanthropy projects in my hand to fulfill my this dream. May God Almighty give me strength to fulfill my this dream Amen! I have even made plans that when I depart from this world who will see my philanthropy work! Looking forward to hearing very soon from you all Best Dr.Afshan Naheed Hashmi www.afshanhashmi.com www.drafshanhashmi.com

Mon, 27 Jul 2015 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/18504/ https://edoc.ub.uni-muenchen.de/18504/1/Patschinski_Pascal.pdf Patschinski, Pascal ddc:540, ddc:500, Fakultät für Chemie und Phar

On the second episode of the Real Life Diabetes Podcast, John Brandenburg joins the DDG Founders Ryan and Amber. His honesty, commitment, and outlook on life and type 2 diabetes was beyond refreshing. Imagine watching your father pass away from diabetes complications, your mother succumb to Alzheimer’s disease with diabetes, and then be given the […] The post A Diagnosis That Catalyzed An Active Lifestyle | John Brandenburg | Real Life Diabetes Podcast #2 appeared first on Diabetes Daily Grind | Real Life Diabetes Podcast.

Justin and Jason discuss meeting AnyFu all-stars Joanna Wiebe and Lance Jones, the eBook that Jason thinks Justin should write, the lessons Jason wants to teach his kids, principles of negotiation, why kids have to learn things the hard way, a post-mortem on the first Catalyst session and what Jason has planned for the second, Rob Walling's advice on buying apps and websites, Justin's new $$ Javascript framework and what it takes for an open source project to take off, how the NSA is recruiting hackers and the AT&T tech who blew the whistle on the NSA's domestic eavesdropping program back in 2006, why Jason thinks Justin would make more money if he marketed himself as an on-demand CTO, how Jason's father-in-law mistakenly deleted every recording on their DVR, the results of Colby's academic standards test and what is says about his personality, the story of Wordspoke.me, why Jason likes Titanium, how Google, Amazon, eBay and Facebook et al. are forming a powerful U.S. lobby called the Internet Association, how NOT to recruit top technical talent, the bacteria that was discovered eating plastic in the Sargasso Sea, AnyFu's true market and why the experts charge so much, and how scientists bioengineered an artificial esophagus.

Sun, 22 May 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13159/ https://edoc.ub.uni-muenchen.de/13159/1/Han_Wei.pdf Han, Wei ddc:540, ddc:500, Fakultät für Chemie und Pharmazie

Thu, 3 Mar 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/12920/ https://edoc.ub.uni-muenchen.de/12920/1/Melzig_Laurin.pdf Melzig, Laurin

Tue, 14 Dec 2010 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/12450/ https://edoc.ub.uni-muenchen.de/12450/1/Sinha_Jyoti.pdf Sinha, Jyoti ddc:540, ddc:500, Fakultät für Chemie und Phar

Fri, 26 Mar 2010 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/11369/ https://edoc.ub.uni-muenchen.de/11369/1/Kienle_Marcel.pdf Kienle, Marcel ddc:540, ddc:50

Thu, 15 Jan 2009 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13992/ https://edoc.ub.uni-muenchen.de/13992/1/Manolikakes_Georg.pdf Manolikakes, Georg

Fri, 14 Dec 2007 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/7824/ https://edoc.ub.uni-muenchen.de/7824/1/Dunet_Guillaume.pdf Dunet, Guillaume ddc:500, ddc:540,

Oxidation reactions of sugars to their corresponding lactones and the selective oxidation of a secondary alcohol of sugar substrates to keto-sugars using transition metal catalysis were investigated. Research results demonstrate that Shvo’s hydrogen-transfer catalyst, [(η4-C4Ph4CO)(CO)2Ru]2, selectively oxidized unprotected sugars to δ-lactones under very mild conditions. This is the first method to synthesize δ-D-galactonolactone, the first oxidation product of the 3rd most abundant sugar. δ-D-Galactonolactone was fully characterized by conformational analysis through NMR experiments and computational methods. We propose that in aprotic, anhydrous solvents the δ→γ lactone rearrangement mechanism proceeds via a bicyclic transition state. The oxidation of alicyclic vicinal diols to α-hydroxy ketones was investigated as a model system for the selective oxidation of a secondary hydroxyl group in sugar substrates to keto-sugars. The challenge was to develop a method that allows selective oxidation, yet prevents over-oxidation to the dione or dicarboxylic acids products. Based on a mathematical model of consecutive bimolecular reactions, the rate constants for the initial oxidation step k1(diol→α-OH ketone) and second oxidation step k2(α-OH ketone→dione) must be k1 > 10 k2 in order to obtain a synthetically useful method for α-hydroxy ketone synthesis. The metal-ligand bifunctional hydrogen transfer reactions of Shvo’s catalyst and Noyori’s η6-arene N-tosyl-1,2-diaminoethane ruthenium(II) complexes were investigated with alcohol model systems and it was concluded that hydrogen transfer reactions are insufficient in the oxidation of vicinal diols due to a unfavourable position of the equilibrium. Under oxidizing conditions, the 16-electron ruthenium complexes of the Noyori systems compete with a β-elimination process and thus new degradation resistant ligands were synthesized. The apparent slower oxidation of Noyori’s η6-arene N-tosyl-1,2-diaminoethane ruthenium(II) complexes under oxidizing conditions, i.e. in acetone or cyclohexanone solvent, was investigated through NMR and IR experiments finding no evidence of a kinetic inhibition by the solvent. We propose that the slower reactions depend on a relatively high energy barrier for the reaction of the 16-electron complex with a hydrogen donor and that a kinetic model must account for two effectively different oxidation and reduction catalysts. In an alcohol/ketone equal-concentration experiment with Noyori-type ruthenium(II) complexes a linear relationship was found between the initial rate of alcohol consumption/production and ∆G°. Reactions involving peroxides as the oxidant were investigated in order to avoid equilibrium processes. The oxidation of alcohol model systems with several Mo and W catalysts and peroxide sources indicated a deactivation of the Mo and W catalysts by formation of water or hydroxide complexes. The product distribution of the oxidation of trans-1,2-cyclohexanediol with the MoO2(acac)2/Na2CO3 x 1.5 H2O2 method was in agreement with the theoretical model, yet only had a k1 = 1.5 k2 rate ratio resulting in a maximum α-hydroxy cyclohexanone content of 45 %. The NiBr2 mediated oxidation of alcohols and benzoylperoxide was investigated. The selective oxidation of vicinal diols was unsuccessful with this method. However, the oxidation reaction of mono-alcohol substrates was greatly improved using water in the reaction. The reaction mechanism was investigated and we propose that the actual oxidant in the NiBr2 mediated benzoylperoxide method is [Br+], which is generated by the hydrolysis product of benzoylhypobromite, hypobromic acid (HOBr). Ishii’s stoichiometric NaHSO3/NaBrO3 reagent selectively oxidized vicinal diols to α-OH ketone without overoxidation. This oxidation reaction was investigated with regards to substrate, concentration and pH. The reactivity and selectivity were studied and it was found that the oxidation mechanism is based on a multitude of comproportionation and disproportionation equilibria at low pH. A small but steadily replenished HOBr concentration is the source of the actual oxidant and effectively acts as a redox buffer. While the NaHSO3/NaBrO3 reagent demonstrated excellent selectivities with the alcohol model systems, the oxidation of sugar substrates failed due to side-reactions occurring at the required low pH.

Gradual depletion of the ozone layer and consequently, increased ultraviolet (UV) radiation on the Earth's surface induces DNA-lesions inside the genome, thereby causing mutations. Three kinds of photoproducts are mainly formed, namely: cyclobutane pyrimidine dimers (CPD), pyrimidine-(6-4)-pyrimidone dimer [(6-4)PP] and the Dewar valence isomer of (6-4)PP lesion. The formation of these photolesions is a major cause of cell death (aging) and fatal disease like skin cancer. A part of this research was performed to investigate the formation and characterization of DNA-lesions under UVC radiation. Small, fluorescent labeled oligonucleotide hairpins (DNA, RNA and mixed DNA-RNA) were employed to this purpose. The amount of damage was quantified using HPLC. Here, a new method was developed, using ion-exchange SAX-column which works at pH = 13, to measure the lesion formation in a direct way. In order to know which lesions are formed, the irradiated hairpins were enzymatically digested. The lesions were separated by HPLC followed by their characterization using MS/MS fragmentation analysis. Investigation was performed to understand the impact of the neighboring nucleobases on the photo-reactivity of a dTpdT-dinucleotide. For this, hairpins were prepared in various sequential contexts. Analysis of these irradiated hairpins revealed the surprising result that the reactivity is strongly reduced when a dTpdT dinucleotide is locked between two neighboring 2'- deoxyguanosines, strongly implying that genomic DNA will be inhomogeneously damaged and hence mutated under UVC radiation. In order to account for the effect of oligonucleotide conformations (A versus B) on the photolesions formation, DNA, RNA and mixed DNA-RNA hairpins were irradiated. The most surprising observation is that the oligonucleotide hairpins, possessing more A-like conformations were found to be very much resistant to UVC degradation. RNA hairpins containing UpU dinucleotides were found to be fully protected from being damaged. A short, dTpdT-containing DNA stretch, embedded in an A-like RNA environment, was also found to be highly stable under UVC light. In the second part of this study, investigation was performed to assay the activities of CPD-photolyase enzyme isolated from different organisms. A synthetic cis-syn thymidine dimer with an open backbone was incorporated into DNA. CPD-photolyases were found to recognize and split this CPDlesion, via a cycloreversion process, into two 2'-deoxythymidine monomers. In order to profile the activities of photolyases and also to study photolyase activity inside living cell, a sensitive DNA-probe, known as molecular beacon was synthesized. The hairpin probe, which features a loop and stem structure contains the model CPD-lesion in its loop region. The molecular beacon (MB 1) in its closed form, is non-fluorescent due to efficient energy transfer (FRET) from the 5'-FAM to 3'-Dabsyl. The MB 1 was designed to undergo strand break on reaction with photolyase in presence of light, thus separating the FAM and the Dabsyl and causing the fluorescence of FAM to be restored. The activities of the photolyase can be studied by monitoring the fluorescence change. Activities of CPDphotolyase isolated from A. nidulans and A. thaliana were studied using this MBprobe. The sensitivity of this probe was tested with wild-type cell-extract from A. thaliana. The fishing-out of photolyase activity from this wild-type extract was possible. Effort was made to investigate the repair process within a living cell, using laser scanning fluorescence microscopy. The insertion of this artificial, chemically modified DNA-substrate in the cell nucleus was achieved.

In the first part, the use of chirality transfer in acyclic allylic systems was assessed for an intra- and an intermolecular reaction. The thermal [2,3] sigmatropic rearrangement of acyclic allylic phosphinites proved to be highly enantioselective, even at 110 °C and led to enantiomerically pure allylic phosphine oxides. The substitution pattern of the substrate and the reaction conditions were fully optimized.The chirality transfer concept was also used intermolecularly in asymmetric allylic substitution reactions. This allowed to build up enantiomerically pure quaternary centers. The product were then reacted to obtain enantionerically pure tertiary alcohols, desymmetrized 1,3 diols and aldol compounds. In a second part, it was found that Heck reaction leading to neopentylic palladium species underwent, in the absence of nucleophile, a C-H activation reaction, leading to spiro cyclopropyl compounds.

In summary, reaction conditions have been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with functionalized alkyl iodides in the presence of TBAI · the application of alkyl bromides in a Csp3-Csp3 cross-coupling reaction. Furthermore, · the presence of sensitive functional groups such as an amino function with an unprotected NH group is tolerated · coupling of diastereomerically enriched zinc reagents proceed with high retention of configuration at the zincated carbon · scaling up can be achieved without significant loss of chemical yield. In summary, an effective and high yielding protection-deprotection protocol has been developed for the iodine-magnesium exchange reaction of 2-iodo-1,4-phenylenediamine. The corresponding 2-magnesiated-1,4-phenylenediamine derivatives can be transmetallated either to copper: · a subsequent allylation reaction furnishes the allylated products in good yield, or to the corresponding zinc reagents: · a subsequent smooth palladium-catalyzed cross-coupling reaction with a range aryl iodides furnishes the polyfunctionalized cross-coupling products in good yield, · this cross-coupling reaction is highly tolerant towards electronic as well as steric effects.

Fri, 1 Jan 1988 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3827/ http://epub.ub.uni-muenchen.de/3827/1/075.pdf Brüggen, Uwe von der; Lammers, Roswitha; Mayr, Herbert Brüggen, Uwe von der; Lammers, Roswitha und Mayr, Herbert (1988): Relative reactivities of acetals and orthoesters in Lewis acid catalyzed reactions with vinyl ethers. A systematic investigation of the synthetic potential of acetals and orthoesters in electrophilic

Thu, 1 Jan 1987 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3824/ http://epub.ub.uni-muenchen.de/3824/1/061.pdf Mayr, Herbert; Koschinsky, Rainer; Will, Elfriede; Bäuml, Englbert Mayr, Herbert; Koschinsky, Rainer; Will, Elfriede und Bäuml, Englbert (1987): Acid- and base-catalyzed ring-opening reactions or a sterically hindered epoxide. In: Journal of Organic Chemistry, Vol. 52, Nr. 7: pp. 1342-1344. Chemie und

Lewis acid catalyzed addition reactions of alkyl halides 1 with unsaturated hydrocarbons 2 have been studied. 1:l addition products 3 are formed if the addends 1 dissociate faster than the corresponding products 3; otherwise, polymerization of 2 takes place. For reaction conditions under which 1 and 3 exist mainly undissociated, solvolysis constants of model compounds can be used to predict the outcome of any such addition reactions if systems with considerable steric hindrance are excluded.

Thu, 1 Jan 1981 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3820/ http://epub.ub.uni-muenchen.de/3820/1/023.pdf Mayr, Herbert; Klein, Herbert Mayr, Herbert und Klein, Herbert (1981): Zinc chloride catalyzed addition reactions of propargyl chlorides with acyclic 1,3-dienes. In: Journal of Organic Chemistry, Vol. 46, Nr. 20: pp. 4097-4100. Ch