Podcasts about alzheimer's disease

Dr. Peter Michalos, a leading MD based in Southampton, NY, joins the program to discuss reports about the president experiencing leg swelling, explaining that the president's condition, chronic venous insufficiency, is common and not related to heart issues. Dr. Michalos also touches on Alzheimer's prevention strategies, stressing the importance of maintaining good blood pressure, dental health, and blood sugar control. Learn more about your ad choices. Visit megaphone.fm/adchoices

I'm joined once again by the brilliant Sarah Banta for a discussion on brain health, and trust me, you don't want to miss this one. We crack open why rates of depression, anxiety, ADHD, autism, and even Alzheimer's are skyrocketing in our modern world. No, it's not just “hormones”, it's a tangled web of gut health, toxins, heavy metals, processed foods, and, believe it or not, little parasites controlling more than just your digestive tract. We're not afraid to dig into topics like SSRIs and their hidden long-term risks. Get ready for raw statistics, real-life stories, and the truth about why so many of us (and our kids) are struggling with issues we didn't see 30 years ago. But I'm not leaving you swirling in stress, we've got solutions! We get practical, talking about targeted supplements, the undeniable gut-brain connection, and the absolute essentials you need to detox and fuel your brain for peak performance. We expose hidden threats in your “healthy” foods and break down realistic, actionable steps to reclaim your mind, your mood, and your quality of life, even if your thyroid's already optimized. If you're tired of band-aid fixes and want to future-proof your brain (or your kid's), this episode is your biohacking blueprint. Sara Banta's Accelerated Health Products: https://acceleratedhealthproducts.com/amie Use code: DRAMIE5 for 5% off WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on  – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 RATE, REVIEW AND FOLLOW ON APPLE PODCASTS If you made it this far I'm impressed! That means you really love the show and I love you for that!  So I'm going to ask you for a favor. Would you please leave a quick review or even 5⭐️. I DO read them and can't tell you how much I appreciate it! Thank you in advance!❤️  Just click here it's quick and easy : https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263,  Ok ONE MORE favor…would you please subscribe and follow the show? This is a win-win! It tells the podcast powers that be that you like The Thyroid Fixer Podcast AND it lets you catch all the new episodes that come out every week. Follow with this link: https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263 and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

Dr. Trey Bateman talks with Dr. Gregg Day about the study design, findings, and clinical implications of using plasma biomarkers in real-world patient care.  Read the related article in Alzheimer's & Dementia.  Disclosures can be found at Neurology.org. 

Don’t miss out on an incredible opportunity this morning to connect with renowned holistic doctor Stephen Tates, who will be in our classroom to address your health concerns directly. Dr. Tates will also tackle urgent issues, including the troubling rise of dementia and Alzheimer’s cases in our community, as well as the latest insights on the resurgence of the COVID-19 virus. Before Dr. Tate's session, we’ll be inspired by the remarkable Dr. Rosie Milligan—a publisher, author, and entrepreneur—who will share the seven vital conversations every family should have before saying goodbye. Before Dr. Rosie, Baltimore's own Dr. David Miller will add further depth to this enriching discussion.See omnystudio.com/listener for privacy information.

Hira Mehta is a retired banker, author of six books, podcaster, voice actor, and filmmaker who focuses on bringing awareness to social causes. In 2024, she made a statement at the UN Convention, New York, on Aging Rights, speaking on behalf of Silver Innings, a non-governmental organization in Mumbai working toward creating an elder- and dementia-friendly world. At the convention, Hira spoke about the rights of senior citizens to healthcare and access to health services.Hira calls herself “a happy senior, crushing stereotypes one day at a time, living life queen-sized.” In this episode, she discusses how the death of her mother made her reflect on the many things her mom had wanted to do but never got to experience—and how that realization inspired Hira to consider what she, herself, still wanted to get out of life.From spreading her wings and beginning her writing career, to the significance of myna birds and their emotional connection to her mother. She initiated Instagram Live interviews during the pandemic to stay connected with friends—a project that grew into over 180 interviews, including a few with celebrities. This eventually led to the start of her podcast, Rewire Life in 1½ Minutes with Hira Mehta, now on Spotify.She talks about the importance of trying new things, never fearing a “no,” her passion for dance and dance reality shows, her views on women's empowerment, and the value of respecting others' cultures and traditions. She supports the mission of Silver Innings in the field of dementia and Alzheimer's and speaks about it in the short film (on YouTube) she made on the cause, “A Selfless Soldier.”Her love of writing led her to submit short stories in a contest. On winning, she continued writing and publishing stories, poetry, and books. And the reminder not to wait for tomorrow to do the things you want to do, but making time to do them now became her mantra of life. (India)

Dr. Trinh joins Michael and Joanie to discuss brain health and prevention of Alzheimer's disease. Be sure to listen in for this special, informative episode of Meaningful Moments!

In this powerful and inspiring episode of UnabridgedMD, host Dr. Isabelle Amigues welcomes Dr. Ward, a chiropractor and functional medicine practitioner, to share his remarkable story of resilience, healing, and clinical transformation. Diagnosed with systemic lupus as a teenager and told he might not live past 30, Dr. Ward defied the odds and turned his diagnosis into a mission to empower others through integrative, lifestyle-based medicine.Together, they explore the intersections of autoimmunity, cognitive decline, and the role of functional medicine in restoring health and hope. Dr. Ward discusses his work using the Bredesen Protocol for Alzheimer's prevention, the impact of lifestyle on chronic disease, and how empowerment and mindset are key to healing.Whether you're a healthcare professional, patient, or simply curious about holistic approaches to wellness, this episode offers a hopeful and science-based roadmap for taking control of your health.

Most dementia caregivers are making this one mistake—and don't even realize it. It leads to more resistance, more frustration, and more burnout. In this video, I'll show you what it is, why it's so common, and what to do instead.

Can Alzheimer's disease be reversed or at least significantly improved?In this powerful interview, Dr. Heather Sandison, a leading expert in dementia prevention and the author of Reversing Alzheimer's, shares what she's learned helping patients dramatically improve memory, regain function, and slow cognitive decline.You'll learn:-How to reverse early Alzheimer's symptoms?-The real causes of Alzheimer's disease-How to prevent Alzheimer's disease-How toxins, insulin resistance, and stress trigger dementia-What tests you should consider to assess your brain health?-The supplements and daily habits that make the biggest difference✨ Resources:Dr. Heather Sandison's website: https://drheathersandison.comHer book Reversing Alzheimer's: https://www.drheathersandison.com/reversing-alzheimers-book/

In this eye-opening episode, Dr. David Bilstrom, internationally recognized autoimmune and chronic disease expert, joins Amb. Elisha to reveal powerful truths about healing the body naturally, preventing autoimmune disease, and the science of epigenetics.   Dr. Bilstrom explains:   • What autoimmune disease really is and why it's skyrocketing worldwide   • Why conditions like type 1 diabetes, autism, and even Alzheimer's may all stem from the same immune root cause   • How the body can self-heal, and why aging symptoms shouldn't begin before age 90   • The role of butyrate and TUDCA in gene expression and disease reversal   • How your lifestyle choices can impact up to 8 future generations through epigenetics   • You'll also learn how to take back control of your health—whether you're 25 or 75—using cutting-edge research that's transforming medicine.   Reach Dr. Bilstrom : http://www.drdavidbilstrom.com/expertscourse ... Want to be a guest on WITneSSes? Send Elisha Arowojobe a message on #PodMatch, here: https://www.podmatch.com/member/ambelisha     Elevate your business with Anastasia's expert consulting. Use code Elisha3 for an exclusive offer and transform your business today! https://resurrectionmentor.wixsite.com/so/42PDEPEB8?languageTag=en   Feel like something's missing? Start Living the Magical Life today. Buy Now: https://a.co/d/4sHrFx2   Amb. Elisha just published a transformational workbook, buy now: https://ambelisha.gumroad.com/l/Llaenlap

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we're going to talk about how peptides might actually help heal your eyes. If that sounds wild, stick with me. There's some amazing early research showing how specific peptides may help with things like macular degeneration, diabetic eye disease, corneal wounds, and even age-related vision loss. We're going to break it all down in plain language, and I'll also explain how each peptide might actually work inside the eye. Let's jump in. AXT107  Let's start with AXT107 — a peptide designed to help stop the growth of abnormal blood vessels in the back of the eye. These rogue vessels are a major problem in conditions like wet macular degeneration and diabetic retinopathy. AXT107 is an injection that's given directly into the eye that targets VEGF and angiopoietin receptors, two major players in abnormal blood vessel growth. In animal studies, it not only stopped new vessels from forming, but also reversed existing damage. Bonus? It forms a little gel-like depot in the eye that slowly releases over time, so it may last longer than current injection-based treatments. BPC-157  If you've heard of peptides for gut repair or injury recovery, you've probably come across BPC-157. But it's also being studied for the eye, especially for corneal healing. BPC-157 eye drops seem to speed up corneal epithelial repair — that's the outer layer of your eye — while reducing inflammation. In rat studies, it helped close up corneal wounds faster, which means it might help with things like dry eye, abrasions, or even post-surgical healing. In fact, while most corneal abrasions fully heal within one to two weeks, BPC-157 can reduce the healing time by several days. Elamipretide (SS31) — The Mitochondria Booster This next peptide is especially intriguing — Elamipretide, also known as SS31. You might remember we've mentioned it before for its potential in age-related and neurodegenerative conditions like Alzheimer's and Parkinson's. But now, researchers are also exploring its role in slowing or even reversing age-related vision decline when given as an eye or subcutaneous injection. This peptide goes deep — literally — into the mitochondria of retinal cells, helping them work more efficiently. In aging mice, Elamipretide improved contrast sensitivity and even reversed some vision loss. So it's not just slowing decline — it may actually restore function. P21  The next peptide is P21. P21 is a neurotrophic peptide, which means it helps keep nerve cells healthy. In the eye, that's a huge deal for preserving vision. P21 protects photoreceptors and retinal pigment cells, while also calming inflammation when given as a subcutaneous injection. In aging rats with retinal damage, it helped reduce nerve cell death and slowed degeneration. Visoluten  Now let's talk about Visoluten, an oral peptide we've discussed before in a previous podcast. As a refresher, it's important to remember that Visoluten is a bioregulatory peptide that helps support the health of the retina—the part of your eye that converts light into the images you see. It works by supporting the metabolic activity of eye tissues, helping maintain healthy vision and improving the eye's ability to adapt to stress, aging, or challenging environmental conditions. Think of it like nutritional support for the eye — especially helpful for people dealing with screen fatigue, bright light exposure, or chronic eye stress.  This peptide helps support the eye's natural metabolic activity, which is key to keeping the retina functioning well and protecting it from things like oxidative stress and environmental wear and tear. Think of it as giving your eyes extra support to stay resilient, especially when they're under strain. Visoluten may also enhance blood flow to the eye, making sure the retina gets the oxygen and nutrients it needs to work properly. That's especially important for people with conditions like age-related macular degeneration or diabetic retinopathy, where poor circulation and tissue damage are part of the problem. Retinalamin  Another oral peptide, Retinalamin, is already being used in some clinical settings — especially in parts of Europe and Asia — for retinal diseases. It helps normalize vascular permeability in the retina and supports repair mechanisms. It's shown benefits in people with glaucoma and diabetic retinopathy, sometimes even improving visual acuity when given intramuscularly or as an injection around the eye. PEDF-Derived Peptides  Here's where things start to feel futuristic — researchers have developed peptides derived from PEDF, or pigment epithelium-derived factor. PEDF is a natural protein found in the eye — especially in the retina. It plays a protective role by preventing damage to light-sensitive cells, reducing inflammation, and blocking abnormal blood vessel growth. PEDF is considered one of the most powerful natural antioxidants and anti-angiogenic (anti–blood vessel growth) factors in the eye. They help protect photoreceptors from stress and damage — without needing gene therapy or injections. These peptides are being turned into eye drops that may slow or stop diseases like retinitis pigmentosa (a group of inherited eye diseases that cause the gradual breakdown of the retina, leading to vision loss that often starts with night blindness and progresses to tunnel vision). They also help with AMD, or age-related macular degeneration (an eye condition that affects the central part of the retina (the macula), leading to blurred or lost central vision, especially in older adults. PHSRN & FGLM-Amide  The next two peptides I want to talk about are PHSRN and FGLM-Amide. They are also being formulated as eye drops and are specifically focused on healing the cornea. They activate something called the fibronectin-integrin system, which basically helps the eye's outer surface cells stick together and heal faster. Great for persistent epithelial defects or those stubborn wounds that don't want to close. ALG-1001 (Luminate)  Finally, there's ALG-1001, also known as Luminate. A peptide that is administered directly into the eye. Luminate is a first-in-class peptide drug that targets integrin receptors in the retina—key players in abnormal blood vessel formation. Instead of targeting VEGF, like current treatments, Luminate blocks integrins upstream, preventing both the growth and leakage of harmful vessels — which can be helpful in AMD and diabetic eye disease. It also has a bonus effect: it helps gently separate the vitreous gel from the retina — a process called pharmacologic vitreolysis. This is especially helpful for people with vitreomacular traction (VMT), a condition where the gel pulls too hard on the retina, causing swelling or vision problems. In clinical studies, about 65% of patients had that pulling relieved after treatment — a result that normally requires surgery. What About Cosmetic Peptides for the Eye Area Just to clarify — eye creams with peptides like Matrixyl 3000, Copper Peptides, or Palmitoyl Tetrapeptide-7 are designed to help with puffiness, dark circles, and fine lines — but they don't affect the internal eye. They work by stimulating collagen in the skin around the eyes — and while great for cosmetic use, they won't help with things like glaucoma or macular degeneration. *Some Words of Caution Most of the peptides we talked about today are still in preclinical or early clinical stages. That means they're promising, but not FDA-approved just yet. So please — no DIY peptide eye drops or injections unless you're working directly with a qualified provider. And as always, if you're dealing with real eye problems, your first stop should be a board-certified ophthalmologist, not a Telegram group or a tweet thread. So there you have it — a quick tour through the exciting, ever-evolving world of peptide therapy for the eyes. From boosting mitochondria to healing corneal wounds, these tiny proteins might be shaping the future of vision care. If you found this episode helpful or interesting, go ahead and share it with someone who stares at screens all day — or your biohacker friend who's already two steps ahead. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Until next time, be well, and as always, have a happy, healthy week.

The news from Northfield, Minnesota on Thursday, July 17th, 2025:Third Thursday This Evening Downtown; Helen Forceythe & The Pan Handlers to PerformNorthfield Memory Mile Raises $12,550 for the Alzheimer's AssociationRice County Officers cite 21 for speeding during pre-holiday enforcement

Happy Wednesday, Heal Squad! We're back with Dr. William Makis for part two of this powerful conversation… and it's one you don't want to miss. If you or someone you love is facing cancer, autoimmune disease, or neurological decline, this episode could shift everything. Dr. Makis shares what he's seeing firsthand in his clinical practice–real stories of patients with stage 4 cancer, lupus, rheumatoid arthritis, even Parkinson's and Alzheimer's—experiencing surprising results with repurposed drugs like ivermectin and mebendazole. He breaks down how and why these low-cost, off-label options are working when nothing else does. We also dive into why many autoimmune symptoms are actually rooted in immune dysregulation, and the real reason alternative  solutions are being ignored (and who's behind it) If you've ever felt like the system isn't giving you the full story, you need to hear this. HEALERS & HEAL-LINERS:  Hormone disruption is on the rise. Testosterone levels are plummeting in men, while women are reporting irregular periods and fertility issues,  and it's not being taken seriously by most doctors. Autoimmune symptoms may be misdiagnosed: Many “mystery” symptoms like fatigue, joint pain, and brain fog are immune system red flags. Repurposed drugs are helping people heal. Medications like ivermectin and LDN (low-dose naltrexone) are being used off-label to reduce inflammation, regulate immune responses, and support recovery from long COVID and chronic illness. -- HEAL SQUAD SOCIALS IG: https://www.instagram.com/healsquad/ TikTok: https://www.tiktok.com/@healsquadxmaria HEAL SQUAD RESOURCES: Heal Squad Website:https://www.healsquad.com/ Heal Squad x Patreon: https://www.patreon.com/HealSquad/membership Maria Menounos Website: https://www.mariamenounos.com My Curated Macy's Page: Shop My Macy's Storefront Prenuvo: Prenuvo.com/MARIA for $300 off Delete Me: https://bit.ly/43rkHwi   code: SQUAD EMR-Tek Red Light: https://emr-tek.com/discount/Maria30 for 30% off Airbnb: https://www.airbnb.com/  Join In-Person Heal Retreat Waitlist! https://mariamenounos.myflodesk.com/heal-retreat-waitlist GUEST RESOURCES:  Instagram Good resources for Ivermectin and Mebendazole are: https://allfamilypharmacy.com/makis/ (CODE MAKIS25) For Fenbendazole: https://shopbplife.com?sca_ref=8426171.Rn4pU8ZWgs5W  (CODE: MAKIS15) For anyone wanting more information on how Ivermectin, fenbendazole, and mebendazole works, or need dosing protocols, connect with Dr. Makis makisw79@yahoo.com Or visit his Substack makismd.substack.com ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content (published or distributed by or on behalf of Maria Menounos or http://Mariamenounos.com and http://healsquad.com) is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions. This podcast is presented for exploratory purposes only. Published content is not intended to be used for preventing, diagnosing, or treating a specific illness. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment.

Episode 2595 - USAID officially shut down. Sweetener causes stroke? Chemtrails are real. Israel attacks Syria! The year of the flood? Eggs reduce Alzheimer's? Plus much more !

Title: From Burnout to Balance: The Holistic Health Framework for Business Leaders with Justin Roethlingshoefer Summary: In this episode, Seth Bradley interviews performance and holistic health expert Justin Roethlingshoefer, who shares his journey from overweight and obsessed with data as a child to becoming a thought leader in elite athletics and executive performance. Justin reveals that while most people approach health through a "body up" lens, obsessing over diets, workouts, and gadgets, true health and healing come from the opposite direction. He advocates for a "top-down" method where spiritual identity and emotional clarity are foundational, which then naturally align the mind and body for sustainable, lasting change. Justin explains how high achievers, even billionaires and franchise owners, often remain unfulfilled and unhealthy because they treat symptoms rather than root causes. His company, Own It, integrates data-driven physical health with deep mental, emotional, and spiritual coaching to create real transformation. True health, he argues, is only possible when all areas of life are aligned — and while results may take time, the impact is profound and permanent. Links to watch and subscribe:   Bullet Point Highlights: Body-up health solutions are backwards. Real, lasting transformation starts with spiritual identity and mindset before physical optimization. Holistic integration is required. Mental, emotional, spiritual, and physical health must be aligned for true healing and performance. Success ≠ health or fulfillment. High-performing entrepreneurs and executives often suffer because they chase outcomes, not alignment. Transformation takes patience. Sustainable results require commitment to small, integrated steps, not quick fixes or shortcuts. The solution is full integration, not fragmentation. Own It's model addresses all aspects of health in one place to create life-changing outcomes. Transcript: Seth Bradley (00:02.062) What's up, builders? This is Raise the Bar Radio, where we talk about building wealth, raising capital, and all in all, raising the bar in your business and your life. This is the No BS podcast for capital raisers, investors, and entrepreneurs who are serious about scaling their business and living life on their own terms. I'm Seth Bradley, securities attorney, real estate investor, and entrepreneur, bringing you world-class strategies from the best in the game. If you're ready to raise more capital, close bigger deals, build a better you, and create true financial freedom, you're in the right place. Let's go. Man, excited to have you on the show. Let's just jump right in, Tell the listeners a little bit about your background and take it back as far as you like. Justin Roethlingshoefer So man, how long's the show? I think the big thing, to be honest with you, anytime I kind of get asked about my background, my background shaped me. My background kind of brought me through to what it is that we're doing now. And I kind of speak in terms of anointings and callings and what it is that was stamped on us from a young age. And for me, it was health. I knew that. When I leaned into that as a young boy at 12, 13 years old, I was a fat kid. was the one that I was just made fun of. But I also had this deep desire to know and understand my body at a level that didn't make sense to a lot of people. And there was, I still remember I did this study at the University of Alberta, born and raised in Canada, and was a very athletic kid, but was just overweight. And I did this study. And they were looking at how kids and based on their habits and behaviors, whether you could actually be fat and fit. And so they brought me in and we did all these tests and all these studies and my VO2 max was at the 99 percentile. My muscle mass was at the 99 percentile. My time spent watching TV, playing video games, all these other things was at the 99th percentile of not doing those things. But yet I had a BMI that was obese. I had a body fat percentage, I think of 34%, something in these areas. And I still remember the article that came out, it was the front page of the paper, because it was a really groundbreaking study in Canada, and it said, and fit, question mark, with a picture of me. and I was on the bike and it really just started, like it messed with my mind. And obviously only continued the teasing, continued all these things. But I was the kid that wore a heart rate monitor to bed, wore a heart rate monitor all day long, had a pulse oximeter that I would look at three, four times a day. When I was reading, when everyone else was reading comic books, I was reading medical journals. And this was something that I was just fully enthralled with. Well, That experience threw me the other direction and from about 14 to 18 became severely anorexic. Had a really hard ability to see myself well and just love who I was and I had a major body composition issue and that propelled me down into the United States. I still happen to be a very good athlete. I came to the United States on a hockey scholarship. Did two undergraduate degrees one in exercise science another nutrition went got my master's degree in exercise physiology concentration and sport performance Went and got my massage therapy license went and got my postgraduate doctoral studies in heart rate variability sleep and recovery science and that propelled me into the National Hockey League I started to really understand the body in a way that not many people did and realizing that health is Holistic health is integrated health is mental physical spiritual and emotional conditions or states of the human being and they all have to be aligned and if there's any type of Disintegration between those four you will not be healed you will not be healthy and you will not realize what I call true health and so I took that philosophy of using data technology and Information to help heal the entire person to the NHL and all of a sudden we started to see injury rates drop, we saw recovery times drop, we saw sickness rates drop, we saw performances increase, we saw energy increase, and the owners, the GMs are coming to saying, what are you doing? Like, I don't understand this. You're bringing a philosophy that is very weird to us, we don't understand it, but yet we see the fruits of it at the end of the day, what's happening? That, over the course of eight years, caused me to become a thought leader and really take... some stages in some unique ways in professional sports and change the culture and the dynamic of how we approached performance. But going from Washington to Anaheim, I had one of the ownership team members of the capitals come and say, hey, I need to meet with you when you come out. And I'd seen this person and as they walked through the door, I was like, my gosh, I'd seen them six months previous. And as they walked through, was like, you've aged 30 years in five, six months. Like what's going on? He's like, I don't know. I don't feel well. Like I'm not sleeping. I'm stressed. I feel like I've got no control of my body and I don't understand what's happening. Can you help me? And the back of my mind, I was like, this guy's a billionaire. He's just making copious amounts of money. He's a businessman. I work with athletes. But then all of a sudden I realized, no, this isn't an athlete problem. This is a human problem. And I put him through the same philosophy. We did testing. We looked at heart rate variability. We started to track information. We started to have conversations that were very philosophical in nature, mentally, physically, spiritually, emotionally aligned, starting to go through a lot of these identities that he had that he wasn't able to shake. And all of a sudden, eight months later, the guy looks like he's 35 years old and He's 80. And that was the turning point for me to be like, hey, I can no longer just stay in the national hockey. Like I have to walk away and be able to impact the health of the world because like I said, this is not just a athlete problem. This is a human problem. And the more that we can empower people, the more that we can help them understand their bodies and understand how to heal. The definition of integrated is the exact same definition of heal. To make one, to make wholeness, to create oneness. And that's what we have to do mentally, physically, spiritually, emotionally if we truly want to heal. You just can't be a muscle head on the outside and be sick internally and think that you're healthy. On the other side, you can't just not go to the gym and go to the therapist all day and be so aligned and do meditation and just know your purpose and be preaching from the stages. there's still disintegration. We need to make sure it's holistic, all-encompassing and integrated to realize that deep healing. And that's what we've been doing for hundreds of thousands of people who are business owners and business leaders, entrepreneurs for the last two and a half, three years. So it's been, that's kind of been that journey in what looks like about six and a half minutes. Seth Bradley That's incredible, man. There's so much to unpack in six and a half minutes there. Man, I don't even know where to start. I mean, it sounds like you've had this almost an obsession with data and reading that data from your body before everybody had a Fitbit, right? Justin Roethlingshoefer Oh, for sure. A Fitbit or some sort of watch, right? And you were doing this before that kind of hit the stage because it just interests. So like on that note, they're like definitely doing it before it was cool. But like quick story, when I was 12 years old, I asked my parents for a heart rate monitor for Christmas. And you have to realize this is back in 1998. So the heart rate monitors were not like they are now. You can't get them for 100 bucks. You can't get a wearable device that's cheap and easy. I think that the heart monitor then cost like $1,600. And they're like, why do you need a heart monitor? Like, are you sick? Is there something wrong? I was like, no, I'm just interested. Well, they're like, we're not buying one of these things. And I said, no, like, pool your money that you give me for Christmas, my birthday, and pool grandma and grandpa's money and pool like aunt and uncle's. Put it all together and that's all I want. You can just never get me a gift for the next year, not till next Christmas. So that's what they did. And that was literally how I got my first piece. And I've just been obsessed with it ever since of really being able to just provide information. Because I think understanding, knowledge is one thing, understanding is something completely different. And we need to be able to dissociate between information and understanding and help cross that bridge so that you can be empowered to take action in your own health. Seth Bradley Yeah. Yeah, that's incredible. Your parents kind of made that sacrifice to make it happen for you. I don't know if you would have been a little bit set back because they didn't provide that for you at that time, but it kind of catapulted you on this journey. You know, do you think that, you know, reading that data is maybe the first step in kind of working towards analyzing that holistic approach? Or where do you kind of see all this beginning? Justin Roethlingshoefer First step is, that's to be honest with you, that's the world's approach. The world's approach I say is a body up approach. So it's, there's four entities of health, right? Mental, physical, spiritual, emotional. And I attach each one of those to a different entity. So physical, your body. Emotional, your heart. Mental, your mind. And spirit, your spiritual component. And the world's approach is to take a bottom up body first approach. You need to get the wearable device. You need to start tracking all this stuff. You need to look at everything under the sun. You need to go get your DNA tested. You need to go get your blood tested. You need to go and do the cold plunge, the sauna, the red light, the intermittent fasting, the high intensity interval training. You have to do all the things because you have to get the six pack. You have to lose 20 pounds. You have to do whatever it might be. It's the body up approach. Well, that body up approach creates a poisoning of the heart, poisoning of the emotions, it brings on anxiety, it brings on fear, it brings on this feeling of overwhelm. All things that I experienced as a child, which is why I continue to pair them through, I was fearful of becoming fat again, thus I took things to an extreme. I was fearful of... not being able to have the energy to do what I wanted, thus I was acting out of certain things and I would have to go do my workouts and it would bring up massive anxiety because it was just so much and I was overwhelmed by it all. That poisoning of the heart creates a separation of the mind, thus I'm not good enough, I'm not strong enough, I'm never gonna get there, I'm not consistent enough, I'm not worthy of all these things. And that separation of the mind creates a cloudiness in our spirit, a cloudiness of who we are and what we identify with. I identified as a fat kid. I identified as the anorexic sick kid, the weird kid. That's what stuck with me and that's why I was never fully healthy even though at 20 years old to now at 36, I don't look any different. I've still got the six pack. I've still got the muscles. I still can lift a house. I still feel really strong. But it's not until about two, maybe even three years ago that I was holistically healthy, that I loved who I was, that I was really rooted. What we have to do is we have to take a top-down approach. We have to really create oneness in our spirit first. Who are we? Why are we here? What's our calling? What's our identity? What is that true desire that we're wanting to live for? Once we have that, we have a sense of oneness of our mind. We are worth it. We are good enough. We're exactly where we need to be. We're in a journey that's exciting. Thus that eliminates and creates a purification of our heart and eliminates the anxieties, eliminates the fears and puts us into a state of enthusiasm, energy, mental clarity, empowerment to go and step forward into these things powerfully, which then we're able to create consistency, sustainability and longevity of our body through our habits, behaviors and lifestyles that are now something we look forward to. And so coming back to your comment is the first thing we have to do is not get the wearable device, is not do the thing. The first thing we have to do is get our self right spiritually, which comes back to identifying who we are. Who do we identify as? What are we? What is our goal, our mission, our purpose? Because once we align that, once we get clear on that, everything else starts to fall into place. Seth Bradley Got it, got it. Yeah, and it's like that body up approach. It's easier to sell. The culture that we live in, it's just easier to sell products. It's easier to get people thinking they need to look a certain way. It's just that sales kind of approach, but it's backwards. You've got to get yourself right spiritually, mentally before the more the body type of physical things can even matter to you internally. Justin Roethlingshoefer I think, yes, I think you're right, but even as you start to look at that, why do you think we're more unhealthy now than ever? We are living in a place where there's more mental illness in our society than ever before. There's more anxiety than ever before. There's more depression than ever before. We're actually sicker physically than ever before. Diabetes is on the rise. Alzheimer's is on the rise. Alzheimer's is just type three diabetes. That's all it is. An inability to control blood sugar. We have an obesity epidemic rising. We have now 52% of Americans that are obese, not overweight, obese. And so it's not more information. It's not getting more of these things. It's not go do this, gym, go and do this thing. There is 77% of people who lose weight and get healthy, gain back the weight they lost. Why? Because it was done in an unsustainable way. They had a hole that they were searching to fill that didn't align along the way. And once they accomplished the certain outcome, it didn't make them feel any different. And so it comes back to this component of integrating everything together. And when I built Own It, that was the big thing I was focused on. Do you have to have an exercise routine? You're darn right you do. Do you have to have a new way of eating? You're darn right you do. Do you want to be able to supplement the right way? You sure do. Do you want to make sure you're sleeping well and have a recovery routine? You're darn right that's important. But you also have to have... the person who's gonna help you with self care, the person who's gonna get your mind right, the person who's gonna get your heart right, the people who are going to help you align in this way, which is why we've got everything in one place and everything had to be integrated. You can't be trying to put your own wheel together because when you put your own wheel together, you miss out. And so I wanted to create a space where somebody could walk in and everything is there. You're gonna come in, you're gonna have your team, your team that wraps their arms around you. You're gonna get your DNA testing, you're gonna get your cellular blood testing, you're gonna get your custom supplementation, you're gonna get your workout plan, you're gonna get your wearable piece of technology so that your health coaches and your functional medicine docs and your RDs can track everything and help you and guide you and put these things in place for you in a slow, iterative way so that over 12 months, you don't even recognize the habits you were in before. But on the same breath, you're gonna be working mentally, emotionally, and spiritually on identifying who you are and how do you get over this gap so we can create a bridge so that you do come in this state of oneness and you step into everything powerfully. And so as a business owner, as an executive, as a business leader, you have become transformed, not conformed to what we're telling you in the world. Seth Bradley Got it. So it truly is holistic, right? It's not let's start one thing two three four. It's all at once small steps to lead to a major change. Justin Roethlingshoefer 100%. And I think the reason that people aren't willing to have patience with it, they're not willing to be developed. Everybody wants to arrive. Everybody wants to get to the end result. But nobody's willing to take the trip. Nobody's willing to have great story. So we had a client who started, this guy owns 17 different franchises and he came to us about three months ago. Four weeks into his process, he called and goes, I'm unhappy, I'm not seeing changes. I've been in this for four weeks and I've just been adding some different habits. I'm looking at my wearable devices. I've just got my testing done. Nothing's changing yet. I said to him — and let's call this guy Chris — I said, Chris... We don't even have your full testing results back yet. We've only really started to implement a lot of these lifestyle changes and routines about three and a half weeks ago. We've only been able to get two really deep in-depth calls to get you realigned. We've only just started to add some of these things in. And you kind of talk him off a ledge, talk him off a ledge. He comes back, continues to be consistent. And just last week... He's been with us, like I said, for about three and a half months. Just last week, he sends us a screenshot. His quality of sleep used to be at about 37%. So REM and deep sleep totals over total time of sleep time. His quality sleep was always about 37%. He just passed 50%. His HRV, which is an intrinsic measure of how your body's adapting to stress and strain... was his average was about 24. Just for a little bit of context, your goal is to always see a trend line upwards. His trend line was always downwards. He has an average HRV now of 54. His respiration rate, meaning how many breaths per minute he's taking throughout the course of the day is dropping, meaning he's becoming more efficient. His blood glucose levels, because we've now tested twice, are half of what they were before. He was at a pre-diabetic level previously. His anxiety in terms of just talking is half of what it was and he's down 16 pounds. Seth Bradley Got it, got it. Yeah, and it's like that body up approach. It's easier to sell. The culture that we live in, it's just easier to sell products. It's easier to get people thinking they need to look a certain way. It's just that sales kind of approach, but it's backwards. You've got to get yourself right spiritually, mentally before the more the body type of physical things can even matter to you internally. Justin Roethlingshoefer I think, yes, I think you're right, but even as you start to look at that, why do you think we're more unhealthy now than ever? We are living in a place where there's more mental illness in our society than ever before. There's more anxiety than ever before. There's more depression than ever before. We're actually sicker physically than ever before. Diabetes is on the rise. Alzheimer's is on the rise. Alzheimer's is just type three diabetes. That's all it is. An inability to control blood sugar. We have an obesity epidemic rising. We have now 52% of Americans that are obese, not overweight, obese. And so it's not more information. It's not getting more of these things. It's not go do this, gym, go and do this thing. There is 77% of people who lose weight and get healthy, gain back the weight they lost. Why? Because it was done in an unsustainable way. They had a hole that they were searching to fill that didn't align along the way. And once they accomplished the certain outcome, it didn't make them feel any different. And so it comes back to this component of integrating everything together. And when I built Own It, that was the big thing I was focused on. Do you have to have an exercise routine? You're darn right you do. Do you have to have a new way of eating? You're darn right you do. Do you want to be able to supplement the right way? You sure do. Do you want to make sure you're sleeping well and have a recovery routine? You're darn right that's important. But you also have to have... the person who's gonna help you with self care, the person who's gonna get your mind right, the person who's gonna get your heart right, the people who are going to help you align in this way, which is why we've got everything in one place and everything had to be integrated. You can't be trying to put your own wheel together because when you put your own wheel together, you miss out. And so I wanted to create a space where somebody could walk in and everything is there. You're gonna come in, you're gonna have your team, your team that wraps their arms around you. You're gonna get your DNA testing, you're gonna get your cellular blood testing, you're gonna get your custom supplementation, you're gonna get your workout plan, you're gonna get your wearable piece of technology so that your health coaches and your functional medicine docs and your RDs can track everything and help you and guide you and put these things in place for you in a slow, iterative way so that over 12 months, you don't even recognize the habits you were in before. But on the same breath, you're gonna be working mentally, emotionally, and spiritually on identifying who you are and how do you get over this gap so we can create a bridge so that you do come in this state of oneness and you step into everything powerfully. And so as a business owner, as an executive, as a business leader, you have become transformed, not conformed to what we're telling you in the world. Seth Bradley Got it. So it truly is holistic, right? It's not let's start one thing two three four. It's all at once small steps to lead to a major change. Justin Roethlingshoefer 100%. And I think the reason that people aren't willing to have patience with it, they're not willing to be developed. Everybody wants to arrive. Everybody wants to get to the end result. But nobody's willing to take the trip. Nobody's willing to have great story. So we had a client who started, this guy owns 17 different franchises and he came to us about three months ago. Four weeks into his process, he called and goes, I'm unhappy, I'm not seeing changes. I've been in this for four weeks and I've just been adding some different habits. I'm looking at my wearable devices. I've just got my testing done. Nothing's changing yet. I said to him — and let's call this guy Chris — I said, Chris... We don't even have your full testing results back yet. We've only really started to implement a lot of these lifestyle changes and routines about three and a half weeks ago. We've only been able to get two really deep in-depth calls to get you realigned. We've only just started to add some of these things in. And you kind of talk him off a ledge, talk him off a ledge. He comes back, continues to be consistent. And just last week... He's been with us, like I said, for about three and a half months. Just last week, he sends us a screenshot. His quality of sleep used to be at about 37%. So REM and deep sleep totals over total time of sleep time. His quality sleep was always about 37%. He just passed 50%. His HRV, which is an intrinsic measure of how your body's adapting to stress and strain... was his average was about 24. Just for a little bit of context, your goal is to always see a trend line upwards. His trend line was always downwards. He has an average HRV now of 54. His respiration rate, meaning how many breaths per minute he's taking throughout the course of the day is dropping, meaning he's becoming more efficient. His blood glucose levels, because we've now tested twice, are half of what they were before. He was at a pre-diabetic level previously. His anxiety in terms of just talking is half of what it was and he's down 16 pounds. Links from the Show and Guest Info and Links: Seth Bradley's Links: https://x.com/sethbradleyesq https://www.youtube.com/@sethbradleyesq www.facebook.com/sethbradleyesq https://www.threads.com/@sethbradleyesq https://www.instagram.com/sethbradleyesq/ https://www.linkedin.com/in/sethbradleyesq/ https://passiveincomeattorney.com/seth-bradley/ https://www.biggerpockets.com/users/sethbradleyesq https://medium.com/@sethbradleyesq https://www.tiktok.com/@sethbradleyesq?lang=en   Justine Roethlingshoefer's Links: https://www.youtube.com/@justinroethlingshoefer https://www.facebook.com/justin.roethlingshoefer https://www.instagram.com/justinroeth/ https://www.linkedin.com/in/justin-roethlingshoefer/ https://justinroethlingshoefer.com/

Recent research found a way to enhance movement that allowed study participants to reduce their levels of cognitive decline, and we talk about how we can incorporate that add-on activity to our own walks or other movement activities we do! And we're back with Judy Benjamin, the 81-year-old walking across America to highlight how we can affect the impact of Alzheimer's disease. Today, she's sharing her best tips for walking!   LET'S TALK THE WALK! Join here for support, motivation and fun in the private Facebook Group for our community! Wellness While Walking Facebook page Wellness While Walking on Instagram Wellness While Walking on Threads Wellness While Walking on Twitter Wellness While Walking website for show notes and other information wellnesswhilewalking@gmail.com   RESOURCES AND SOURCES (some links may be affiliate links) FOOT STRENGTH + MIMINALIST OR ZERO DROP SHOES Gait Happens is my go-to organization for all things foot function and footwear recommendations -- check them out! Click "Individuals" to get actionable info about foot pain, foot exercises and footwear recommendations! WWW Ep. 144: Feet First with Dr. Courtney Conley of Gait Happens: How Our Feet Are Pivotal to Walking and Our Health WWW Ep. 145: Walking Pain, Balance, Agility and Footwear: Dr. Courtney Conley of Gait Happens, Part 2 on our Fit Feet! JUDY BENJAMIN, PhD. and COACH Judy Walks:Website about the Walk Judy Walks America Instagram Account https://accesslongevity.com Judy's Email judy@accesslongevity.com DR. DALE BREDESEN The First Survivors of Alzheimer's: How Patients Recovered Life and Hope in Their Own Words, Dr. Dale Bredesen "Kristin"/Patient Zero is Judy!   HOW TO RATE AND REVIEW WELLNESS WHILE WALKING How to Leave a Review on Apple Podcasts on Your iOS Device 1.   Open Apple Podcast App (purple app icon that says Podcasts). 2.   Go to the icons at the bottom of the screen and choose “search” 3.   Search for “Wellness While Walking” 4.   Click on the SHOW, not the episode. 5.   Scroll all the way down to “Ratings and Reviews” section 6.   Click on “Write a Review” (if you don't see that option, click on “See All” first) 7.   Then you will be able to rate the show on a five-star scale (5 is highest rating) and write a review! 8.   Thank you! I so appreciate this!   How to Leave a Review on Apple Podcasts on a Computer  1.   Visit Wellness While Walking page on Apple Podcasts in your web browser (search for Apple Podcasts or click here)  https://www.apple.com/apple-podcasts/ 2.   Click on “Listen on Apple Podcasts” or “Open the App” 3.   This will open Apple Podcasts and put in search bar at top left “Wellness While Walking” 4.   This should bring you to the show, not a particular episode – click on the show's artwork 5.   Scroll down until you see “Rating and Reviews” 6.   Click on “See All” all the way to the right, near the Ratings and Review Section and its bar chart 7.   To leave a written review, please click on “Write a Review” 8.   You'll be able to leave a review, along with a title for it, plus you'll be able to rate the show on the 5-star scale (with 5 being the highest rating) 9.   Thank you so very much!! OTHER APPS WHERE RATINGS OR REVIEWS ARE POSSIBLE Spotify Goodpods Overcast (if you star certain episodes, or every one, that will help others find the show)  Castbox Podcast Addict Podchaser Podbean   HOW TO SHARE WELLNESS WHILE WALKING Tell a friend or family member about Wellness While Walking, maybe while you're walking together or lamenting not feeling 100% Follow up with a quick text with more info, as noted below! (My favorite is pod.link/walking because it works with all the apps!) Screenshot a favorite episode playing on your phone and share to social media or to a friend via text or email! Wellness While Walking on Apple – click the up arrow to share with a friend via text or email, or share to social media Wellness While Walking on Spotify -- click the up arrow to share with a friend via text or email, or share to social media Use this universal link for any podcast app: pod.link/walking – give it to friends or share on social media Tell your pal about the Wellness While Walking website Thanks for listening and now for sharing! : )       DISCLAIMER Neither I nor many of my podcast guests are doctors or healthcare professionals of any kind, and nothing on this podcast or associated content should be considered medical advice. The information provided by Wellness While Walking Podcast and associated material, by Whole Life Workshop and by Bermuda Road Wellness LLC is for informational and entertainment purposes only. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment, and before undertaking a new health care regimen, including walking.     Thanks for listening to Wellness While Walking, a walking podcast and a "best podcast for walking"!

Laughter is good for our souls. It's especially good for those who have dementia, providing healing for those who grieve, no matter what our cognitive ability level might be. Today's "all over the place" episode starts off hilariously with "Gomer the bull" and a visit to Andy's Custard. Next is Mary Anne's description of falling on a slippery bathroom floor, added with the discussion of GeneSight, a pharmacogenomic test which analyzes how genes may affect medication outcomes. The GeneSight test is important for understanding genetic variations in your DNA. Results can inform your healthcare provider about how you may break down or respond to certain medications commonly prescribed to treat depression, anxiety, ADHD, and other psychiatric conditions, including dementia and Alzheimer's. www.verandaministries.org www.genesight.com Balcony People by Joyce Landorf Heatherly https://a.co/d/h00Ht0J

THE GOOD DEATH VIRTUAL BOOK TOUR: Suzanne B. O'Brien RN in Conversation with Krista Montague, CDP, AT-BC. In this insightful episode, we sit down with Krista Montague—dementia care specialist and founder of Dementia Success Path—to unpack the complexities of dementia and Alzheimer's, from understanding the differences and stages to recognizing early signs and managing challenging behaviors with compassion. Krista shares practical strategies for de-escalation, emphasizes the powerful role of community support for overwhelmed caregivers, and explains how genetics and lifestyle intersect in Alzheimer's risk, offering hope through prevention and healthy habits. She also highlights the urgent need for legal and financial planning after diagnosis, including setting up powers of attorney and living trusts to safeguard families. This conversation is a reassuring guide for anyone touched by dementia, reminding us that no one has to face this journey alone.   (00:02) Understanding Dementia and Alzheimer's (10:26) Recognizing Early Signs of Dementia (15:20) Legal and Financial Planning for Dementia (22:10) Managing Challenging Behaviors in Dementia (27:52) Understanding Challenging Behaviors in Dementia (35:50) Navigating Reality in Dementia Care (39:10) Caregiving for Late-Stage Dementia Patients (44:32) Supporting Dementia Caregivers    Register to join us for FREE: THE GOOD DEATH BOOK CLUB EXPERIENCE: 12 MONTH FREE DEATH AND DYING COURSE  Or visit our website here!  GET THE GOOD DEATH BOOK Here     Meet our guest: Krista Montague, CDP, AT-BC Founder, Dementia Success Path Website: dementiasuccesspath.com Caregiver Mental Health Cheatsheet - Click Here! Facebook Group: Dementia Caregiver Support & Activities for Challenging Behaviors Community Private group Instagram: @dementiasuccesspath YouTube: Dementia Success Path    Please Share! Know someone who is a caregiver, healthcare worker, or spiritual seeker? Share this episode and invite them to join this sacred and supportive experience.    Listen & Subscribe: Available on Apple Podcasts • Spotify • Google Podcasts • YouTube       JOIN MY FREE TRAINING AND MEMBERSHIP SITE   This is a community-supported group hosted by Suzanne B. O'Brien RN, founder of the International Doulagivers Institute for training those who want to be professional End of Life Doulas, Doulagiver Practitioners and for anyone wanting more EOL education Join Here: 4491664174178077   ⚑ SUBSCRIBE TO MY CHANNEL ⚑ If you want to do great things you need to have a great environment. Create the life you want by surrounding yourself with positivity and watching daily.  Click here to subscribe!   ツ  CONNECT WITH ME  ツ Leave a comment on this video and it'll get a response. Or you can connect with me on different social platforms too: Instagram Facebook TikTok Website Podcast     #deathdoula #deathdoultraining #dyingwell #death #life #deatheducation #doulagivers #hospice #hospicecare #hospicenurse #deathdoula #soulmidwife #deathmidwife #endoflifeplanning #healthcareproxy #funerals #fearofdeath #endoflifedoula #thegooddeath #hospice #grief #deathawareness #birth #endoflife #deathpositivity #consciousdying #dying #advanceplanning #deathpositive #gooddeath #consciousliving #endoflifedirective #palliativecare #advancedirective #livefully #suzannebobrien. #lifecafe #consciousness #awarenes

When Patrick Patrick Kitana Ettenes bluntly told his father "I suck dick, daddy" at 15 years old, it marked just one turning point in a life brimming with extraordinary challenges and triumphs. Born in Barbados in 1983 to a Dutch father and Trinidadian mother, Patrick's childhood was a paradox of privilege and pain—his father's high-profile security work with prime ministers and diplomats couldn't shield him from relentless bullying due to his feminine expression.Patrick's shocking classroom experiences included teacher-orchestrated "games" where students chased and attacked him, leaving him with bruises and scratches his mother eventually noticed. Despite this trauma, he emerged with an indomitable spirit, eventually leaving Barbados for Cuba on a psychology scholarship at just 15, before settling in Manchester, UK, where he finally found community and acceptance.But life in England wasn't the paradise he hoped for. Patrick survived an abusive relationship that left him homeless, battled substance abuse, contracted HIV, and was diagnosed with early onset dementia in his early thirties. Yet rather than succumbing to these challenges, he transformed them into fuel for activism. Finding no support groups for LGBTQ+ people with dementia, he created them himself, launching the "Bring Dementia Out" initiative with the Alzheimer's Society.Patrick's identity journey is equally compelling—identifying as non-binary and sometimes presenting as female at conferences, he embraces both sides of himself while rejecting the pressure to undergo gender confirmation surgery after learning it might affect his sexual pleasure. His perspective on dementia is particularly remarkable, describing how as his brain degenerates, his empathy and intuition have heightened, giving him what he calls a "superpower" to help others.Have you encountered someone whose resilience fundamentally changed how you view adversity? this extraordinary conversation that will challenge your perspectives on sexuality, gender, disability and the transformative power of turning personal trauma into community advocacy. Read more about Patrick's work and diagnosis herePresented by Emma Goswell Produced by Sam Walker We'd love to hear YOUR story. Please get in touch www.comingoutstoriespodcast.com or find us on twitter @ComeOutStories and on Instagram @ComingOutStoriesPod We have a book! Coming Out Stories is available at all major shops now! JKP.com | Queerlit | Waterstones | Amazon Coming Out Stories is a What Goes On Media Production

Feeling frustrated with midlife weight gain and cravings that just won't quit? You're not alone — and it's not just about willpower.In this episode, Amy breaks down the real reasons behind that stubborn midsection fat, shares the critical connection between estrogen and brain health, and how to work with your body (not against it) with five essential habits so you can reclaim your energy and protect your brain. What to Listen For[00:02:00] Why menopause weight gain is more than just a vanity issue — it's about brain and metabolic health.[00:03:00] The surprising link between declining estrogen, insulin resistance, and increased Alzheimer's risk.[00:05:00] Why prioritizing sleep is non-negotiable for managing cravings and protecting your brain.[00:10:00] Simple bedtime habits to improve sleep — including a two-minute version if you feel overwhelmed.[00:11:00] The power of five servings of colorful fruits and vegetables (and how to make it easy).[00:13:00] Why plant proteins like soy, lentils, and nuts can be your midlife superfoods.[00:15:00] How starting your day with water (before coffee!) supports energy and reduces cravings.[00:17:00] The importance of daily nervous system resets for stress, emotional eating, and brain health.[00:19:00] Tiny movement habits that help you maintain muscle, balance insulin, and sleep better.[00:20:00] How to shift your mindset from battling your body to partnering with it — and what the weight set point theory means for midlife women.Recommended Complimentary EpisodesEpisode 239: [Back To Basics] How To Make Habits StickEpisode 272: The Essential Stress Response ToolkitEpisode 283: The Vagus Nerve: Your Brain's Hidden Ally Against Alzheimer'sWeight gain during menopause isn't a battle to win — it's an invitation to support your brain and body with compassion and smart habits. Listen now, subscribe, and share this episode with a friend who needs to hear it!Subscribe & Review in iTunesIf you like what you hear, please subscribe to my podcast.  I encourage you to do that today as I don't want you to miss an episode.  Click here to subscribe on iTunes!Now if you're feeling extra loving, I would be really grateful if you left me a review over on iTunes, too. Those reviews help other people find my podcast and they're also fun for me to go in and read. Just click here to review, select “Ratings and Reviews” and “Write a Review” and let me know what your favorite part of the podcast is.RESOURCES: Register for the FREE Masterclass: 5 Keys to Protecting Your Brain Health Book a FREE Discovery Call with Amy Lang Order Amy's book Thoughts Are Habits Too: Master Your Triggers, Free Yourself From Diet Culture, and Rediscover Joyful Eating. Follow Amy on Instagram @habitwhisperer

Normal pressure hydrocephalus (NPH) is a pathologic condition whereby excess CSF is retained in and around the brain despite normal intracranial pressure. MRI-safe programmable shunt valves allow for fluid drainage adjustment based on patients' symptoms and radiographic images. Approximately 75% of patients with NPH improve after shunt surgery regardless of shunt type or location. In this episode, Aaron Berkowitz, MD, PhD, FAAN, speaks with Kaisorn L. Chaichana, MD, author of the article “Management of Normal Pressure Hydrocephalus” in the Continuum® June 2025 Disorders of CSF Dynamics issue. Dr. Berkowitz is a Continuum® Audio interviewer and a professor of neurology at the University of California San Francisco in the Department of Neurology in San Francisco, California. Dr. Chaichana is a professor of neurology in the department of neurological surgery at the Mayo Clinic in Jacksonville, Florida. Additional Resources Read the article: Management of Normal Pressure Hydrocephalus Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @LyellJ Guest: @kchaichanamd Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Berkowitz: This is Dr Aaron Berkowitz, and today I'm interviewing Dr Kaisorn Chaichana about his article on management of normal pressure hydrocephalus, which he wrote with Dr Jeremy Cutsforth-Gregory. The article appears in the June 2025 Continuum issue on disorders of CSF dynamics. Welcome to the podcast, and please introduce yourself to our audience. Dr Chaichana: Yeah, thank you for having me. I'm Kaisorn Chaichana. I'm a neurosurgeon at Mayo Clinic in Jacksonville, Florida. Part of my practice is doing hydrocephalus care, which includes shunts for patients with normal pressure hydrocephalus. Dr Berkowitz: Fantastic. Well, before we get into shunt considerations and NPH specifically, which I know is the focus of your article, I thought it would be a great opportunity for a neurologist to pick a neurosurgeon's brain a bit about shunts. So, to start, can you lay out for us the different types of shunts and shunt procedures, the advantages, disadvantages of each type of shunt, how you think about which shunt procedure should be used for which patient, that type of thing? Dr Chaichana: Yeah. So, there are different types of shunts, and the most common one that is used is called a ventricular peritoneal shunt. So, it has a ventricular catheter, it has a catheter that tunnels underneath the skin and it goes into the peritoneum where the fluid goes from the ventricular system into the peritoneum. Typically, the shunts are in the ventricle because that is the largest fluid-filled space in the brain. Other terminal areas include the atrium, which is really the jugular vein, and those are called ventricular atrial shunts. You can also have ventricular pleural shunts, which end in the pleural space and drain flui into the pleural space. Those are pretty much the most common ventricular shunts. There's also a lumboperitoneal shunt that drains from the lumbar spine, similar to a lumbar drain into the peritoneum. For the lumbar shunts, we don't typically have a lumbar pleural or lumbar atrial shunt just because of the pressure dynamics, because the lumbar spine is below the lung and as well as the atrium. And so, the drainage pattern is very different than ventricular peritoneal which is top to bottom. The most common shunt, why we use the ventricular peritoneal shunt the most, is because it has the most control. So, the peritoneum is set at a standard pressure in the intraabdominal pressure, whereas the ventricular atrial shunt depends on your venous return or venous pressure and your ventricular pleural shunt varies with inspiration and expiration. So, the easiest way for us to control the fluid, the ventricular system is through the ventricular peritoneal shunt. And that's why that's our most common shunt that we use. Dr Berkowitz: Fantastic. So, as you mention in the article, neurologists may be reluctant to offer a shunt to patients with NPH because many patients may not improve, or they improve only transiently; and out of fear of shunt complications. So, of course, as neurologists, we often only hear about a patient's shunt when there is a problem. So, we have this sort of biased view of seeing a lot of shunt malfunction and shunt infection. Of course, we might not see the patient if their shunt is working just fine. How common are these complications in practice, and how do you as a neurosurgeon weigh the risks against the often uncertain or transient benefits of a shunt in a patient with NPH who may be older and multiple medical comorbidities? How do you think about that and talk about it with patients? Dr Chaichana: When you hear about shunt complications, most of the shunt complications you hear about are typically in patients with congenital hydrocephalus. Those patients often require several shunt revisions just from either growing or the shunt stays in for a long time or the ventricular caliber is a lot less than some with normal pressure hydrocephalus. So, we don't really see a lot of complications with normal pressure hydrocephalus. So that shunt placement in these patients is typically pretty safe. The procedure's a relatively short procedure, around 30 minutes to 45 minutes to place a shunt, and we can control the pressure within the shunt setting so that we don't overdrain---which means too much fluid drains from the ventricular system---which can cause things like a subdural, which is probably the most common complication associated with normal pressure hydrocephalus. So, to obviate those risks, what we do is typically insert the shunt and then keep the shunt setting at a high setting. The higher the setting, the less it drains, and then we bring it slowly down based on the patient's symptoms to try to minimize the risk of this over drainage in the subdural hematoma while at the same time benefiting the patient. So, there's a concern for shunt in patients with normal pressure hydrocephalus. The concern or the complication risks are very low. The problem with normal pressure hydrocephalus, though, is that over time these patients benefit less and less from drainage or their disease process takes over. So, I do recommend placing this shunt as soon as possible just so that we can maximize their quality of life for that period of time. Dr Berkowitz: So, if I'm understanding you, then the risk of complication is more sort of due to the mechanical factors in patients with congenital hydrocephalus or sort of outgrowing the shunt, their pressure dynamics may be changing over time. And in your experience, an older patient with NPH, although they may have more medical comorbidities, the procedure itself is relatively quick and low-risk. And the actual complications due to mechanical factors, my understanding, are just much less common because the patient is obviously fully grown and they're getting one sort of procedure at one point in time and tend to need less revision, have less complication. Is that right? Dr Chaichana: Yeah, that's correct. The complication risk for normal hydrocephalus is a lot less than other types of hydrocephalus. Dr Berkowitz: That's helpful to know. While we're talking about some of these complications, let's say we're following a patient in neurology with NPH who has a shunt. What are some of the symptoms and signs of shunt malfunction or shunt infection? And what are the best studies to order to evaluate for these if we're concerned about them? Dr Chaichana: Yeah. So basically, for shunt malfunction, it's basically broken down into two categories. It's either overdrainage or underdrainage. So, underdrainage is where the shunt doesn't function enough. And so basically, they return to their state before the shunt was placed. So that could be worsening gait function, memory function, urinary incontinence are the typical symptoms we look for in patients with normal pressure hydrocephalus and underdrainage, or the shunt is not working. For patients that are having overdrainage, which is draining too much, the classic sign is typically headaches when they stand up. And the reason behind that is when there's overdrainage, there's less cerebrospinal fluid in their ventricular system, which means less intracranial pressure. So that when they stand up, the pressure differential between their head and the ground is more than when they're lying down. And because of that pressure differential, they usually have worsening headaches when standing up or sitting up. The other thing are severe headaches, which would be a sign of a subdural hematoma or focality in their neurological symptoms that could point to a subdural hematoma, such as weakness, numbness, speaking problems, depending on the hemisphere. How we work this up is, regardless if you're concerned about overdrainage or underdrainage, we usually start with a CAT scan or an MRI scan. Typically, we prefer a CAT scan because it's quicker, but the CAT scan will show us if the ventricular caliber is the same and/or the placement of the proximal catheter. So, what we look for when we see that CAT scan or that MRI to see the location of the proximal catheter to make sure it hasn't changed from any previous settings. And then we see the caliber of the ventricles. If the caliber of the ventricles is smaller, that could be a sign of overdrainage. If the caliber of the ventricles are larger, it could be a sign of underdrainage. The other thing we look for are subdural fluid collections or hydromas or subdural hematomas, which would be another sign of lower endocranial pressure, which would be a sign of overdrainage. So those are the biggest signs we look for, for underdrainage and overdrainage. Other things we can look for if we're concerned of the shunt is fractured, we do a shunt X-ray and what a shunt x-ray is is x-rays of the skull, the neck and the abdomen to see the catheter to make sure it's not kinked or fractured. If you're really concerned, you can't tell from the x-ray, another scan to order is a CT of the chest and abdomen and pelvis to look at the location of the catheter to make sure there's no brakes in the catheter, there's no fluid collections on the distal portion of the catheter, which would be a sign of shunt malfunction as well. Other tests that you can do to really exclude shunt malfunction is a shunt patency test, and what that is a nuclear medicine test where radionucleotide is injected into the valve and then the radionucleotide is traced over time or imaged through time to make sure that it's draining appropriately from the valve into the distal catheter into the peritoneum or the distal site. If there's a shunt malfunction that's not drainage, that radioisotope would remain stagnant either in the valve or in the catheter. There's overdrainage, we can't really tell, but there will be a quick drainage of the radioisotope. For shunt infection, we start with an imaging just to make sure there's not a shunt malfunction, and that usually requires cerebrospinal fluid to test. The cerebrospinal fluid can come from the valve itself, or it can come from other areas like the lumbar spine. If the lumbar spine is showing signs of shunt infection, then that usually means the shunt is infected. If the valve is aspirated with- at the bedside with a butterfly needle into the valve and that shows signs of shunt infection, that also could be a sign of infection. Dr Berkowitz: That's very helpful. You mentioned CT and shunt series. One question that often comes up when obtaining neuroimaging in patients with a shunt, who have NPH or otherwise, is whether we need to call you when we're doing an MRI to reprogram the shunt before or after. Is there a way we can know as a neurologists at the bedside or as patients carry a card, like with some devices where we know whether we have to call and bother our neurosurgery colleagues to get this MRI? Or if the radiology techs ask us, is this safe? And is the patient's shunt going to get turned off? How do we go about determining this? Dr Chaichana: Yeah, so unfortunately, a lot of patients don't carry a card. We typically offer a card when we do the shunt, but that card, there's two problems with it. One is it tells the model, but the second thing is it has to be updated any time the shunt is changed to a different setting. Oftentimes patients don't know that shunt setting, and often times they don't know that company brand that they use. There are different types of shunts with different types of settings. If there's ever concern as to what type of shunt they have, an x-ray is usually the best bet to see with a shunt series, or a skull x-ray. A lateral skull x-ray usually looks at the valve, and the valve has certain radio-dense markers that indicate what type of shunt it is. And that way you can call neurosurgery and we can always tell you what the shunt setting is before the MRI is done. Problem with an MRI scan if you do it without a shunt x-ray before is that you don't know the setting before unless the patient really knows or it's in the patient chart, and the MRI can need to change the setting. It doesn't usually turn it off, but it would change the setting, which would change the fluid dynamics within their ventricular system, which could lead to overdrainage or underdrainage. So, any time a patient needs MRI imaging, whether it's even the brain MRI, a spine MRI, or even abdominal MRI, really a shunt x-ray should be done just to see the shunt setting so that it could be returned to that setting after the MRI is done. Dr Berkowitz: So, the only way to know sort of what type of shunt it would be short of the patient knowing or the patient getting care at the same hospital where the shunt was placed and looking it up in the operative reports would be a skull film. That would then tell us what type of shunt is there and then the marking of the setting. And then we would be able to call our colleagues in neurosurgery and say, this patient is getting an MRI this is the setting, this is the type of shunt. And do we need to call you afterwards to come by and reprogram it? Is that right? Dr Chaichana: That's correct, yeah. Dr Berkowitz: Is there anything we would be able to see on there, or it's best we just- best we just call you and clarify? Dr Chaichana: The easiest thing to do is, when you get the skull x-ray, you can Google different types of shunts or search for different shunts, and they'll have markers that show the type of shunt it is as well as the setting that it's at. And just match it up with the picture. Dr Berkowitz: And as long as it's not a programmable shunt, there's no concern about doing the MRI. Is that right? Dr Chaichana: Correct. So, if it's a programmable shunt, even if it's MRI-compatible, we still like to get the setting before and make sure the setting after the MRI is the same. Nonprogrammable shunts can't be changed with MRI scans, and those don't need neurosurgery after the MRI scan, but it should be confirmed before the scan is done. Dr Berkowitz: Very helpful. Okay, so let's turn to NPH specifically. As you know, there's a lot of debate in the literature, some arguing, even, NPH might not even exist, some saying it's underdiagnosed. I think. I don't know if it was last year at our American Academy of Neurology conference or certainly in recent years, there was a pro and con debate of “we are underdiagnosing NPH” versus “we are overdiagnosing NPH.” What's your perspective as a neurosurgeon? What's the perspective in neurosurgery? Is this something we're underdiagnosing, and the times you shunt these patients you see miraculous results? Is this something that we're overdiagnosing, you get a lot of patients sent to that you think maybe won't benefit from a shunt? Or is it just really hard to say and some patients have shunt-responsive noncommunicating hydrocephalus of unclear etiology and either concurrent Parkinson's disease, Alzheimer's, cervical lumbar stenosis, neuropathy, vestibular problems, and all these other issues that play into multifactorial gait to sort of display a certain amount of the percentage of problem in a given patient or take overtime? What's your perspective if you're open to sharing it, or what's the perspective of neurosurgery? Is this debated as it is in neurology or this is just a standard thing you see and patients respond to shunt to some degree in some proportion of the time? And what are the sort of predictors you see in your experience? Dr Chaichana: Yeah, so, for me, I'd say it's too complicated for a neurosurgeon to evaluate. We rely on neurology to tell us whether or not they need a shunt. But I think the problem is, obviously, a part of the workout for at least the ones that I like to do, is that I want them to have a high-volume lumbar puncture with pre- and postgait analysis to see if there's really an objective measure of them improving. If they have an objective measure of improvement---and what's even better is that they have a subjective measure of improvement on top of the objective measure of improvement---then they benefit from a shunt. The problem is, some patients do benefit even though they don't have objective performance increases after a high-volume shunt. And those are the ones that make me the most worrisome to do the shunt, just because I don't like to do a procedure where there's no benefit for the patient. I do see, according to the literature as well, that there's around a 30 to 40%, even 50%, increase in gait function, even in patients that don't have large improvements following the high-volume lumbar puncture. And those are the most challenging patients for us as neurosurgeons because we'll put the shunt in, they say we're no better in terms of their gait, no better in terms of their urinary incontinence. We try to lower their shunt down to a certain setting and we're kind of stuck after that point. The good thing about NPH, though, is that, from the neurosurgery side, the shunt, like I said, is a pretty benign, low-risk procedure. So, we're not putting the patient through a very severe procedure to see if there's any benefit. So, in cases where we try to improve their quality of life in patients that don't have a benefit from high-volume lumbar puncture, we give them the odds of whether or not it's improving and say it might not improve. But because the procedure's minimally invasive, I think it's a good way to see if we can benefit their quality of life. Dr Berkowitz: Yeah, it's a very helpful perspective. Yeah, those are the most challenging cases on our side as well, right. If the patient- we think they may have NPH, or their gait and/or urinary and/or cognitive problems are- at least have a component of NPH that could be reversible, we certainly want to do the large volume lumbar puncture and/or consider a lumbar drain trial, all discussed in other articles and interviews for this issue of Continuum, But the really tough ones, as you said, there is this literature on patients who don't respond to the large-volume lumbar puncture for some reason but still may be shunt responsive. And despite all the imaging predictors and all the other ways we try to think about this, it's hard to know who's going to benefit. I think that's really a helpful perspective from your end that, as you say in the very beginning of your article, right, maybe there's a little bit too much fear of shunting on the neurology side because when we hear about shunts, it's often in the setting of complication. And so, we're not sort of getting the full spectrum of all the patients you shunt and you see who are doing just fine. They might not improve---the question is related to NPH---but at least they're not harmed by the shunt, and we're maybe overbiased and/or seeing a overly representative sample of negative shunt outcomes when they're actually not that common in practice. Is that a fair summary of your perspective? Dr Chaichana: Yeah, that's correct. So, I mean, complications can occur---and anytime you do a surgery, there are risks of complications---but I think they're relatively low for the benefit that we can help their quality of life. And the procedure's pretty short. So, the risk, it mostly outweighs the benefits in cases with normal pressure hydrocephalus. Dr Berkowitz: Very helpful perspective. So, well, thanks so much again. Today I've been interviewing Dr Kaisorn Chaichana about his article on management of normal pressure hydrocephalus, which he wrote with Dr Jeremy Cutsforth-Gregory. This article appears in the most recent issue of Continuum on disorders of CSF dynamics. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Join us for a compelling episode with Emma Soy, founder and CEO of Gentle Shepherd Care, as we explore her innovative approach to navigating Alzheimer's care and other forms of elder care. With over 35 years of nursing experience, Emma shares her journey from healthcare professional to entrepreneur, founding her company in 2019 to help older adults age gracefully in place. In this discussion, Emma addresses common mistakes families make in elder care, the importance of creating a comprehensive care plan, and her unique Rejuvenate program aimed at improving the quality of life for those with chronic diseases. Additionally, Emma offers insights on holistic approaches to care, necessary policy changes, and practical advice for caregivers. Don't miss this valuable conversation that could make a significant impact on how we care for our aging loved ones.SPECIAL REQUEST:Please share this episode with anyone you know who is challenged with caring for a loved one who is suffering from dementia, Parkinson's, or other age-related diseases. There's a great deal of valuable info here.CHAPTERS:00:00 Introduction to Alzheimer's and Dementia00:12 Meet Emma Soy: Founder of Gentle Shepherd Care00:23 Emma's Journey and Vision for Elder Care02:17 Challenges in Traditional Home Care03:14 Introducing the Rejuvenate Program04:33 Seven Devastating Mistakes in Elder Care06:29 Importance of Planning for Aging17:04 Hidden Interventions for Memory Care20:09 Eliminating Harmful Foods for Memory Care20:46 Recommended Diets for Older Adults21:27 Challenges in Changing Dietary Habits22:36 Creating Healthy Meal Plans24:00 The Role of Professional Help in Dietary Changes26:03 Fragmentation in Healthcare Systems28:01 Responsibility for Personal Health28:53 Policy Changes Needed in Elder Care30:42 Impact of Healthcare Policy on Providers35:23 Contact Information and Services OfferedAbout Bob Gatty Bob Gatty is a former journalist and communications consultant, the founder and editor of the Lean to the Left blog and host of this podcast. He's co-author of "Hijacked Nation, Donald Trump's attack on America's greatness. Link: https://amzn.to/4ePrTF7. Lean to the Left pulls no punches in calling out Trump, Musk & Co., who are turning our country into their own personal piggybank. If you enjoy this commentary, please visit, subscribe and share the Lean to the Left podcast. Meanwhile, please share your stories and experiences by commenting on this video and offering your thoughts. Your voice matters!

En Las Mañanas de RNE con Lara Hermoso, nos fijamos, en la creación del Consorcio Global de Proteómica de la Neurodegeneración (GNPC). Se ha abierto de forma gratuita para la comunidad científica la mayor base de datos armonizada de proteínas relacionadas con las enfermedades del Alzheimer, el Parkinson, la demencia frontotemporal y la Esclerosis Lateral Amiotrófica (ELA). Esta compilación incluye 250 millones de mediciones únicas, cerca de 40.000 muestras de fluidos vitales, como el plasma sanguíneo o el líquido cefalorraquídeo, que provienen de 23 grupos de personas, de diferentes partes del mundo."Este estudio demuestra que podemos identificar nuevos marcadores en sangre, no solo para el Alzheimer, también para el Parkinson, demencia frontotemporal y ELA (...) Hemos visto en estos estudios que en alguna de estas proteínas, los niveles respecto a controles, cambian incluso antes de lo que son los síntomas clínicos (entre 5 y 10 años), por lo tanto vamos a poder desarrollar nuevos marcadores que van a poder identificar personas que tienen el riesgo de desarrollar estas enfermedades", nos contaba el doctor Carlos Cruchaga es director del Laboratorio de Neorogenómica en la Universidad Washington en San Luis (Misuri, EEUU), que forma parte de este GNPC.Escuchar audio

Up to 3,500 FDA staffers received their final walking papers Monday after the U.S. Supreme Court found last week that the government is “likely to succeed” in arguing that its overhaul of HHS is “lawful.” Meanwhile, FDA Commissioner Marty Makary floated policy changes for the agency, including a proposal to lower prescription drug user fees for the next iteration of the program, and one to offer speedier reviews to companies willing to lower the cost of their drugs.  Last week, the regulator opened its cache of complete response letters (CRLs), offering transparency into the rationale behind more than 200 recent rejections for ultimately approved therapies, including those for Eli Lilly's Alzheimer's drug Kisunla and Sarepta's Duchenne muscular dystrophy (DMD) treatment Vyondys 53. The FDA did not, however, release the CRLs for two new rejections: those of therapies from Ultragenyx and Capricor Therapeutics in Sanfilippo syndrome type A and cardiomyopathy associated with DMD, respectively. It was an especially rough week for Ultragenyx, which also, along with partner Mereo BioPharma, released seemingly negative Phase II/III data for their osteogenesis imperfecta therapy.  On a more positive note, two bustling therapeutic spaces continue to see positive data. In obesity, Hengrui Pharma's Kailera Therapeutics–partnered dual GLP-1/GIP receptor agonist elicited 17.7% average weight loss in a pivotal Chinese trial. And the psychedelic therapeutics space is again generating excitement with two recent positive readouts in treatment-resistant depression. BioSpace took a deep dive into the market reaction to these readouts for Compass Pathways and Beckley Psytech and atai Life Sciences, and what exactly investors are looking for in a successful psychedelic therapy.  Finally, we examine the progress of AI biotech unicorns and kick off our series on women in biopharma with profiles on Mayo Venture Partner Audrey Greenberg and the all-female CEO/R&D tandem at Acadia Pharmaceuticals.  

When you think of the microbiome, you probably think of your gut. But bacteria live all over your body. And they're incredibly numerous; you play host to about as many microbes — a hundred trillion of them — as you do human cells.As my guest will explain, these microbial ecosystems are not only ubiquitous but hugely influential for your health — impacting everything from your weight and mood to your risk of developing many diseases.Dr. Brett Finlay is a microbiologist and the co-author of The Microbiome Master Key. Today on the show, Brett explains what the microbiome is, how modern life — including our overemphasis on hygiene — has damaged it, and how the quality of your microbiome is connected to nine of the top ten leading causes of death, as well as everything from depression to Parkinson's. Brett also shares how we can boost the health of our microbiome, including whether probiotic supplements are effective, how something as simple as flossing your teeth can cut your risk of Alzheimer's by 50%, and why you might want to let your dog lick you in the face.Resources Related to the PodcastLet Them Eat Dirt documentaryAoM Article: How and Why to Eat More FiberAoM Article Don't Be a Stick in the Mud — Why You Should Let Your Kids Get DirtyProbiotic gumConnect With Brett FinlayBrett's faculty page

Did you know that your daily habits directly affect the speed at which your brain is ageing and your risk of getting Alzheimer's disease in the future?   This week, I'm delighted to welcome Dr Darshan Shah to the podcast. Darshan is a medical doctor, a board-certified surgeon, an expert in preventive health and the founder of Next Health, the first health optimisation and longevity centre to offer life-extending and enhancing technology and treatments.   Whilst working as a surgeon, Darshan became seriously ill with type diabetes, hypertension, an autoimmune condition, and he was told he had a 50% chance of dying in the next 25 years. This wake-up call came just as his first son was born. Rather than accepting a life dependent on medications, he immersed himself in functional medicine and completely reversed his conditions in just eight months.    During our conversation, you'll discover:  The 5 things you could start doing today that would actually increase your chances of getting Alzheimer's The 80/20 principle for health and how focusing on just 20% of interventions can deliver 80% of the results Why sitting for more than four hours increases your risk of death by 15% Why becoming the "boss of your own biology" through tracking key biomarkers could be life-saving How inflammation from your gut and mouth can directly impact your brain health decades later Darshan's top supplement recommendations for longevity This conversation challenges the notion that we can simply live intuitively in today's environment and expect to stay healthy. Darshan argues that in our current toxic world, taking an active role in monitoring and optimising our health isn't just beneficial, it's essential.  Whether you're interested in detailed health tracking or just want to learn the basics of staying well, this conversation is packed with practical advice that could transform how you think about your health. I hope you enjoy listening. Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.   Thanks to our sponsors: https://join.whoop.com/livemore https://boncharge.com/livemore https://timeline.com/livemore https://thriva.co   Show notes https://drchatterjee.com/573   DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

All Home Care Matters and our host, Lance A. Slatton were honored to welcome Katrina Love Prescott as guest to the show.   About Katrina Love Prescott:   Katrina Love Prescott is an award-winning Caregiver Advocate, Coach, and Media Producer. As co-founder of Care Nation, a non-profit dedicated to supporting caregivers, she has partnered with leading organizations for over a decade to enhance the quality of life for those with chronic illnesses and their caregivers. Her acclaimed web series, Therapeutic Fibbing, exploring a family's journey with dementia, has garnered over 2 million views.   Her latest project, Things Not to Say to a Caregiver, has surpassed 1 million views and continues to resonate widely. Passionate and innovative, Katrina is committed to transforming the caregiver experience.   About "Things Not To Say To A Caregiver":   A sharp, funny web series where a no-nonsense Care-y Godmother rewrites the awkward, hurtful things people say to caregivers—turning missteps into moments of empathy, growth, and comic relief. Synopsis: Things Not to Say to a Caregiver is a comedic web series that tackles the awkward, misguided things people say to caregivers—and how we can do better. Each episode, led by a sharp-tongued “Care-y Godmother,” flips a cringeworthy moment into a teachable one. Blending sketch comedy with real-life insight, TNTS validates caregivers' experiences while educating the public with humour and heart.    Connect with Katrina Love Prescott: Official Website: https://www.katrinaloveprescott.com Instagram: @katprescott  Tik Tok: kat.prescott LinkedIn: https://www.linkedin.com/in/katrina-love-prescott-5799157/ Facebook: https://www.facebook.com/katrina.prescott/   Watch "Things Not To Say To A Caregiver": YouTube Playlist: https://www.youtube.com/playlist?list=PLNKwjxd98HaUZ-hY7tzB8DDXLvJI1BHzh

In this eye-opening episode, I am joined by renowned olive oil expert Dr. Rod Mailer to uncover the shocking truths behind one of the most misunderstood ingredients in our kitchens: olive oil. Together, we explore the science, sourcing, and scandals behind olive oil—what it really means when a bottle says “extra virgin,” how processing and storage impact its quality, and why so much of what we buy may not be what it claims to be. We also dive into the science of why seed oils—like canola, soybean, and sunflower—pose serious health risks, and how they've infiltrated modern diets to a dangerous degree. Whether you're a health-conscious consumer or just want to know what's actually in your food, this episode will change the way you think about fat. About Dr. Rod Mailer: Dr. Rodney Mailer is a leading expert in olive oil quality and production, instrumental in developing Australia's olive oil industry. He founded and led the Australian Oils Research Laboratory and has worked globally to combat adulteration and ensure authenticity in extra virgin olive oil. Dr. Mailer continues to help shape international standards for edible oils through his roles with the International Standards Organisation, Codex Alimentarius, and Standards Australia. *** Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Fatty15: Get 15% off your 90-day Starter Kit when you visit www.fatty15.com/neuro | Code: NEURO Boncharge: www.boncharge.com | Code: NEURO15 Branch Basics: www.branchbasics.com to shop their Premium Starter Kit and save 15% | Code: NEURO Ketone IQ: www.ketone.com/NEURO for 30% OFF your subscription order + receive a free gift with your second shipment MUDWTR - The coffee alternative. If you're ready to ditch the crash and sip smarter, go to mudwtr.com and use code NEURO to get 43% off + free shipping. *** Topics discussed: 00:00:08: The harmful effects of seed oils 00:01:35: Misinformation via social media 00:02:56: Why are seed oils killing us? 00:09:51: Why fry in seed oil and not olive oil? 00:17:50: How olive oil is manufactured 00:19:33: Different types of olives 00:23:01: Olive oil tasting 00:25:24: The controversy of the olive oil industry 00:28:09: Cold pressed olive oil 00:35:00: Which oil to buy in Australia 00:37:11: Storage and shipment issues 00:38:36: What to look for in the supermarket 00:41:12: What makes olive oil bad? 00:44:10: The importance of the manufacturer 00:45:09: Labeling discrepancies of olive oil 00:49:38: Anything can sell on Amazon 00:51:01: Unknowing blending of oils 00:53:27: Consuming olive oil for longevity 00:54:52: Clinical epidemiology *** I'm Louisa Nicola — clinical neuroscientist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_

[This is one of the finalists in the 2025 review contest, written by an ACX reader who will remain anonymous until after voting is done. I'll be posting about one of these a week for several months. When you've read them all, I'll ask you to vote for a favorite, so remember which ones you liked] “The scientific paper is a ‘fraud' that creates “a totally misleading narrative of the processes of thought that go into the making of scientific discoveries.” This critique comes not from a conspiracist on the margins of science, but from Nobel laureate Sir Peter Medawar. A brilliant experimentalist whose work on immune tolerance laid the foundation for modern organ transplantation, Sir Peter understood both the power and the limitations of scientific communication. Consider the familiar structure of a scientific paper: Introduction (background and hypothesis), Methods, Results, Discussion, Conclusion. This format implies that the work followed a clean, sequential progression: scientists identified a gap in knowledge, formulated a causal explanation, designed definitive experiments to fill the gap, evaluated compelling results, and most of the time, confirmed their hypothesis. Real lab work rarely follows such a clear path. Biological research is filled with what Medawar describes lovingly as “messing about”: false starts, starting in the middle, unexpected results, reformulated hypotheses, and intriguing accidental findings. The published paper ignores the mess in favour of the illusion of structure and discipline. It offers an ideal version of what might have happened rather than a confession of what did. The polish serves a purpose. It makes complex work accessible (at least if you work in the same or a similar field!). It allows researchers to build upon new findings. But the contrived omissions can also play upon even the most well-regarded scientist's susceptibility to the seduction of story. As Christophe Bernard, Director of Research at the Institute of Systems Neuroscience (Marseilles, Fr.) recently explained, “when we are reading a paper, we tend to follow the reasoning and logic of the authors, and if the argumentation is nicely laid out, it is difficult to pause, take a step back, and try to get an overall picture.” Our minds travel the narrative path laid out for us, making it harder to spot potential flaws in logic or alternative interpretations of the data, and making conclusions feel far more definitive than they often are. Medawar's framing is my compass when I do deep dives into major discoveries in translational neuroscience. I approach papers with a dual vision. First, what is actually presented? But second, and often more importantly, what is not shown? How was the work likely done in reality? What alternatives were tried but not reported? What assumptions guided the experimental design? What other interpretations might fit the data if the results are not as convincing or cohesive as argued? And what are the consequences for scientific progress? In the case of Alzheimer's research, they appear to be stark: thirty years of prioritizing an incomplete model of the disease's causes; billions of corporate, government, and foundation dollars spent pursuing a narrow path to drug development; the relative exclusion of alternative hypotheses from funding opportunities and attention; and little progress toward disease-modifying treatments or a cure. https://www.astralcodexten.com/p/your-review-of-mice-mechanisms-and

Surprise bitch! Aman makes his Round 3 debut on this month's livestream episode where we're joined by Keely and Ethan! We discuss Cynthia Erivo, Lindsay Heather Pearce, and why we shouldn't be bitchy to "Bitch." Songs this episode include: Anything Goes/ Anything You Can Do Damn It, Janet I'll Remember Mamma Mia ---- Become a Patron for exclusive bonus episodes, guest announcements, and access to live episode recordings @ ⁠⁠⁠⁠patreon.com/gleekoftheweekpod⁠⁠⁠⁠ Rate us five stars on Spotify and Apple Podcasts ⁠⁠⁠⁠Buy our Merch!⁠⁠⁠⁠ Leave us a voicemail @ (347)719-1160 Follow us on Instagram ⁠⁠⁠⁠@gleekoftheweekpod⁠⁠⁠⁠ Follow us on Tiktok ⁠⁠⁠⁠@gleekoftheweekpod⁠⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Your life insurance policy might be a valuable financial tool you can leverage now, not just in the future? Discover the surprising potential of life insurance as a current asset. For those navigating the financial realities of dementia care or planning for aging in place, the often-overlooked value within a life insurance policy could offer unexpected solutions. We'll explore how accessing this value could help fund crucial long-term care needs. Perhaps you need to make essential home modifications for independent living. Learn why the 90% of life insurance policies are surrendered; representing a missed opportunity for many. Discover a different perspective on your life insurance and how it could provide financial flexibility you might not have realized was possible. Our Guest: Rob Haynie - Settlements.com Rob has significantly shaped the life settlement industry. For instance, he's directly negotiated thousands of settlements. Currently, he serves on the Board of Directors of LISA. Furthermore, he's a charter member of LISA's PPC committee. This committee focuses on the industry's regulations and laws. +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ Related Episodes: Long-term Care - Low Cost Options Home Dementia Care Alarm: Crisis in Long-term Care ++++++++++++++++++++++++++++++++++++++++ Sign Up for more Advice & Wisdom - email newsletter. Please help us keep our show going by supporting our sponsors. Thank you. ++++++++++++++++++++++++++++++++++++++++ Make Your Brain Span Match Your LifeSpan Relevate from NeuroReserve With Relevate nutritional supplement, you get science-backed nutrition to help protect your brain power today and for years to come. You deserve a brain span that lasts as long as your lifespan. ++++++++++++++++++++++++++++++++++++++++ Feeling overwhelmed? HelpTexts can be your pocket therapist. Going through a tough time? HelpTexts offers confidential support delivered straight to your phone via text message. Whether you're dealing with grief, caregiving stress, or just need a mental health boost, their expert-guided texts provide personalized tips and advice. Sign up for a year of support and get: Daily or twice-weekly texts tailored to your situation Actionable strategies to cope and move forward Support for those who care about you (optional) HelpTexts makes getting help easy and convenient. ++++++++++++++++++++++++++++++++++++++++ List of the Top 20 Alzheimer's Podcasts via FeedSpot! See where we rank. Join Fading Memories On Social Media! If you've enjoyed this episode, please share this podcast with other caregivers! You'll find us on social media at the following links. Instagram LinkedIn  Facebook Contact Jen at hello@fadingmemoriespodcast.com Or learn more at Our Website

#181: Death doesn't have to be a cold, clinical experience tucked away in hospital corners. Yet the word "hospice" still strikes fear in the hearts of so many, often because we fundamentally misunderstand what hospice truly offers.In this profound conversation with Karissa, a veteran hospice nurse with eight years of experience across four different states, we peel back the layers of misconception surrounding end-of-life care. "If death is inevitable, it matters where and when and how," she explains, challenging our cultural tendency to avoid these conversations until it's often too late.What exactly happens when hospice steps in? Far from being just for the imminently dying, hospice provides comprehensive support for both patients and families, sometimes for years rather than days. Karissa walks us through the full spectrum of resources available – from 24/7 nursing support and equipment to spiritual care and family counseling – all covered 100% by Medicare and Medicaid. We explore the telltale signs that it might be time to consider hospice for conditions like CHF, COPD, Alzheimer's, and cancer, and why waiting too long often leads to preventable suffering.Perhaps most beautifully, Karissa describes her role as "midwifery for the dying," drawing a powerful parallel between how we usher life into this world and how we can compassionately guide it out. Whether you're a healthcare provider hesitant to broach this topic with patients, a family member wondering if it's time to consider additional support, or simply someone wanting to understand this inevitable part of the human experience, this episode offers practical wisdom, honest insights, and unexpected moments of lightness in what's typically considered a heavy subject. Listen, share, and join the conversation about making the end of life as meaningful and comfortable as possible.You can now send us a text to ask a question or review the show. We would love to hear from you! Follow me on social: https://www.instagram.com/babbles_nonsense/

What is the current impact of Alzheimer's disease and related dementias on the United States? To best understand its significance in 2025, we can turn to the Alzheimer's Association's Alzheimer's Disease Facts and Figures report, a comprehensive resource that highlights the effect of Alzheimer's on individuals, care partners, health care professionals and more. Dr. Heather Snyder from the Alzheimer's Association joins the podcast to discuss key trends and findings from this year's report, including insights from their special report on Americans' attitudes toward early detection and new monoclonal antibody treatments. Guest: Heather Snyder, PhD, senior vice president, medical & scientific relations, Alzheimer's Association Show Notes Read the 2025 Alzheimer's Disease Facts and Figures report and special report from the Alzheimer's Association on their website. Download and print the 2025 Alzheimer's Disease Facts and Figures infographic on their website. Read about Dr. Snyder on her profile on the Alzheimer's Association website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production.

What if aging wasn't inevitable? Dr. Joy Kong—triple board-certified anti-aging physician and stem cell expert—says you can slow it down and even reverse it. As the founder of Chara Health and Chara Biologics, a global leader in regenerative medicine, she helps people transform their health using the body's natural intelligence. Dr. Kong founded the American Academy of Integrative Cell Therapy (AAICT) and has trained physicians around the world. She has been named Stem Cell Doctor of the Year and Stem Cell Doctor of the Decade. Her therapies have successfully helped people with degenerative disease, cognitive decline like Alzheimer's, fertility issues as well as age reversal. Tune into Women Road Warriors with Shelley Johnson and Kathy Tuccaro to discover how science, stem cells, and nature are changing the trajectory of aging.https://www.charahealth.com/www.charoomni.comhttps://joykongmd.com/https://womenroadwarriors.com/ https://womenspowernetwork.net#AntiAging #StemCellTherapy #DrJoyKong #JoyKongMD #CharaHealth #CharaBiologics #ShelleyMJohnson #ShelleyJohnson #KathyTuccaro #WomenRoadWarriors

In this heartwarming episode, Jean Lee, AlzAuthors founder and author of Alzheimer's Daughter, joins us to discuss her personal journey of caring for both of her parents after their simultaneous Alzheimer's diagnosis. Jean shares how she journaled her family's dementia journey, the emotional process of turning those notes into a memoir, and the discovery of her parents' World War II love letters during the difficult process of moving them into memory care. The conversation covers crucial topics facing caregivers—navigating diagnoses, managing moves to different care facilities, supporting siblings at a distance, and confronting the emotions tied to sharing private family stories. Listeners will also hear about the importance of community, storytelling, and connecting with others who understand life on the dementia journey. Plus, don't miss Jean's poignant reading of her parents' correspondence and practical tips for families facing similar challenges. What You'll Hear In This Episode: Hear Jean's personal story of caring for both parents, who were diagnosed with Alzheimer's on the same day. Learn how her experience as a “hometown daughter” shaped her perspective on dementia and caregiving.Jean shares how a simple journal became an essential tool for tracking her parents' symptoms, achieving an earlier diagnosis, and eventually forming the backbone of her memoir.Discover the emotional and logistical challenges of transitioning parents with dementia into assisted living and secure memory care, and hear practical advice on how to handle repeated moves.An honest discussion about the moment of diagnosis—how doctors communicate difficult news, and what families can do when left with more questions than answers.Jean recounts the touching discovery of her parents' WWII love letters and how these preserved memories added richness and hope to her storytelling.Explore what keeps couples bonded through the trials of Alzheimer's, and how caregivers can find strength in family history and shared memories.From note-taking systems to balancing a full-time career with caregiving, Jean offers actionable strategies for dementia caregivers. After the Podcast Purchase “Alzheimer's Daughter” Read one of Jean's many blog posts Listen to another podcast featuring Jean Lee Learn about the Moderators Marianne Sciucco Christy Byrne Yates About the Podcast AlzAuthors is the global community of authors writing about Alzheimer's and dementia from personal experience to light the way for others. Our podcast introduces you to our authors who share their stories and insights to provide knowledge, comfort, and support. Please subscribe so you don't miss a word. If our authors' stories move you, please leave a review. And don't forget to share our podcast with family and friends on their own dementia journeys. We are a 501(c)(3) charitable organization totally reliant on donations to do what we do. Your generosity will help cover our many operating costs, which include website hosting and maintenance fees, service charges to keep things running smoothly, and marketing expenses to promote our authors, expand our content, improve our reach, and more. Our ongoing work supports our mission to lift the silence and stigma of Alzheimer's and other dementias. To sustain our efforts please donate here Ideas and opinions expressed in this podcast belong to the speakers and not AlzAuthors. Always consult your healthcare provider and legal and financial consultants for advice on any of the topics covered here. Thanks for listening. We are a Whole Care Network Featured Podcast Proud to be on The Health Podcast Network Find us on The World Podcast Network and babyboomer.org Want to be on the podcast? Here's what you need to know. We've got merch! Shop our Store

Dr. Beverly Thorn, a clinical psychologist with extensive experience in neuroscience and chronic illness, shares her personal journey and professional insights in her book "Before I Lose My Mind." The book is a resource for caregivers, focusing on the challenges and emotional toll of caring for a loved one with dementia. Dr. Thorn's journey began when her husband, Walt, was diagnosed with Alzheimer's disease in 2013, leading her to become his primary caregiver until his passing in 2020. The book is structured into three parts: pre-diagnosis and early progression, serious disease progression, and life after Walt. It offers personal stories, practical advice, and electronic resources for caregivers. Dr. Thorn emphasizes the importance of caregiver self-care, the role of end-of-life doulas, and the need for a supportive community. She also addresses common issues such as survivor guilt and the emotional challenges faced by caregivers. Dr. Thorn continues to support caregivers through speaking engagements and her online resource directory, aiming to provide guidance and support for those navigating similar journeys. For more details visit https://drbeverlythorn.com/Video recording at https://www.retirementlivingsourcebook.com/videos/beverly-e-thorn-ph-d-author-of-before-lose-my-own-mind-navigating-life-as-a-dementia-caregiver

Lisa Skinner, who has worked with Alzheimer's patients for many years, discusses her book "Truth, Lies, and Alzheimer's: Its Secret Faces."

In this powerful episode of Research Renaissance, host Deborah Westphal sits down with Dr. Rachel Buckley, Associate Professor of Neurology at Massachusetts General Hospital and Harvard Medical School. Together, they explore a growing body of research that challenges long-standing assumptions about sex differences in Alzheimer's disease.Dr. Buckley shares her unexpected journey from skepticism to advocacy in studying how biological sex and hormonal changes—particularly around menopause—can influence Alzheimer's risk, pathology, and progression. From PET scans to postmortem tissue studies, she unpacks what we now know about tau pathology in women, the role of hormone therapy, and how reproductive history may shape brain health.You'll also hear about:Why women are disproportionately impacted by Alzheimer's—and why it's more than just longevityHow timing of hormone therapy may impact tau buildupSurprising research around pregnancy, caregiving, and even the X chromosomeWhere the research gaps still exist—and how AI might help close themWhy training the next generation of sex-based neuroscientists is essentialWhether you're a caregiver, clinician, researcher, or simply curious about how brain health intersects with gender, this episode offers eye-opening insight and hope for the future.Guest Bio: Dr. Rachel Buckley is an internationally recognized neuroscientist focused on the intersection of sex differences and Alzheimer's disease. She leads groundbreaking research at Massachusetts General Hospital and serves as Chair of the Alzheimer's Association's Sex and Gender Professional Interest Area.Resources & Links: 

Send us a textJose Santana of the Easterseals Day Break at the Miller Center (Winter Park, FL) helps us understand another option for care, what to expect, and how to shop for it.Easterseals Day Break at the Miller Center - Winter ParkPhone: (407) 629-4565Support the Alzheimer's & Dementia Resource Center

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. Takeda has taken the lead in the race for a narcolepsy treatment with back-to-back phase III wins for their drug Oveporexton. Investors are eagerly awaiting breakthroughs in using psychedelics to treat depression. Ultragenyx faced a setback as the FDA rejected their gene therapy for Sanfilippo syndrome, citing manufacturing issues. The FDA is considering speeding up reviews for companies that promise to lower drug costs. Market reaction to recent readouts from Compass Pathways and Beckley Psytech/Atai in treatment-resistant depression shows the challenges psychedelic therapies must overcome for commercial viability. Rainin Micropro offers a solution to streamline NGS preparation with their 96-channel pipettor. The industry is also focused on precision diagnostics to support precision therapeutics in the future. AstraZeneca's Baxdrostat showed promising results in lowering blood pressure in a phase III trial. The ADA revealed R&D priorities for potential blockbuster obesity treatments. Relmada has abandoned development of a depression drug after three failed attempts.The challenges faced by psychedelic therapies in the treatment of depression are discussed, as recent readouts from Compass Pathways and Beckley Psytech/Atai in treatment-resistant depression have left investors wanting more. The market reaction highlights the hurdles psychedelic therapies must overcome to prove their commercial viability. Additionally, the importance of precision diagnostics in the development of next-generation precision oncology therapies is emphasized, stating that only with the adoption of digital imaging and AI-powered analysis will these therapies reach their full potential. The FDA has several important decisions lined up, including applications in lymphoma, rare diseases, and hormone deficiency, while the American Diabetes Association's annual meeting reveals R&D priorities for weight loss medicines. Topics discussed include Capricor's FDA rejection of a DMD cell therapy, the ALS community petitioning the FDA to reconsider Brainstorm's Nurown, and updates on COVID-19 vaccines and Alzheimer's drugs. Upcoming webinars and job opportunities in the biopharma industry are also included.

Latt Mansor explores the multifaceted role of ketones, particularly their influence on brain health, fertility, memory, and focus. The re-release of an episode from 2023 delves into their impact on serotonin receptors, blood glucose regulation, and weight management. Mansor also highlights the potential therapeutic benefits of ketones for conditions such as sleep disturbances, infertility, depression, and Alzheimer's. If you want a balanced approach to health discussions, where scientific understanding encourages expanded knowledge and experience rather than limitations, this is the episode for you. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep296 Dr. Latt Mansor holds a Ph.D. in Physiology, Anatomy and Genetics from the University of Oxford, where his research focused on the metabolism of type 2 diabetic heart in hypoxia. He also holds an M.A. (Columbia University) and a B.Sc. (Hons) (University of Nottingham) in Biotechnology. He is a world expert in physiology and metabolism and consults with elite sports, military, clinical and research organizations. Check out our fasting membership at resetacademy.drmindypelz.com. Please note our medical disclaimer.

In this episode, Nurse Doza explores The Master Antioxidant: 5 Ways Glutathione Supports Your Health. Learn how glutathione impacts liver detoxification, brain health, inflammation reduction, hormone balance, and chronic disease prevention. Discover practical ways to boost glutathione naturally and why it's essential for optimal energy, longevity, and overall wellness. 5 KEY TAKEAWAYS Liver Health Support: Glutathione is critical for liver detoxification and reversing fatty liver disease. Brain Function Boost: Low glutathione levels are linked to cognitive decline, Alzheimer's, and Parkinson's. Inflammation Reduction: Glutathione neutralizes oxidative stress, reducing chronic inflammation throughout the body. Hormone Balance: Proper glutathione levels help regulate estrogen metabolism and reduce breast cancer risk. Disease Prevention: Every chronic disease is linked to glutathione deficiency—raising levels improves resilience and recovery. FEATURED PRODUCT Boost by MSW Nutrition features glutathione alongside a powerful multivitamin blend, helping your body detoxify, fight inflammation, and improve energy naturally. Whether you're focused on reversing fatty liver, supporting brain health, or reducing inflammation, Boost delivers the master antioxidant directly to your system—keeping you energized and protected every day.

Parenting Up family - today's episode is a special one! The worlds of sports memorabilia and caregiving collide in this deeply personal glimpse into my journey to honor my father's extraordinary legacy while navigating the daily challenges of caring for my mother with Alzheimer's.My father, Jock Michael Smith, accomplished something unprecedented - creating the largest sports memorabilia collection in modern history. Not as a full-time collector or dealer, but as a successful attorney who pursued this passion nights and weekends throughout his career. While the world recognizes many brilliant lawyers, only one person created a collection of this magnitude and significance - a Black man from Queens whose passion preserved pivotal moments in sports and cultural history.When MeTV's reality show about collectors reached out to me, I was finally ready to speak about my father and the collection I inherited. I showcased eight iconic pieces from my father's collection of thousands. From Muhammad Ali's sweat-stained robe to Michael Jordan's double-signed jersey to Curt Flood's game-changing uniform, each item tells a story beyond sports, documenting moments when individuals challenged societal norms and made history.This journey reminds us that dreams don't expire - they manifest on their own timeline. After 13 years since my father's passing, his collection is finally gaining the recognition it deserves. Whatever your passion, stay true to it. Build your team, follow your heart, and know that your moment will come, even if it takes longer than expected.Executive Producer: J Smiles Producer: Mia HallEditor: Annelise UdoyeBTS Videographer: Isaiah  Support the show"Alzheimer's is heavy but we ain't gotta be!"IG: https://www.instagram.com/parentingupFB: https://www.facebook.com/parentingupYT: https://www.youtube.com/channel/UCDGFb1t2RC_m1yMnFJ2T4jwPatreon: https://patreon.com/jsmilesstudiosTEXT 'PODCAST" to +1 404 737 1449 - to give J topic ideas, feedback, say hi!Be sure to leave us a review!

In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain's heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions. Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health. Learn more about Dr. Julie Andersen and the Buck Institute: https://www.buckinstitute.org/lab/andersen-lab/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Leave Health Bite a Feedback.Click This Link.What if an Alzheimer's diagnosis doesn't have to mean the end of purpose, connection, and meaningful living - but rather the beginning of a deeper understanding of what truly matters?With 6.7 million Americans age 65 and older living with Alzheimer's disease - a number expected to reach 13.8 million by 2060 - we often focus on the statistics and the decline. But what about how people are living with this diagnosis? What about the wisdom, growth, and profound insights that can emerge even in the face of cognitive change?In this episdoe, Dr. Adrienne Youdim sits down with Dr. Gregory Nelson, a leadership expert, speaker, and professional musician who has courageously shifted his life's work to advocacy after receiving his own early-stage Alzheimer's diagnosis.Who is Dr. Gregory Nelson?Leadership consultant and coach who worked with major companies including Amazon and FitbitExpert in self-awareness development with decades of experience helping leaders understand themselvesAdvocate for breaking the silence and shame around cognitive declineWhat You'll Discover in This Episode:How early-stage Alzheimer's can look very different from common misconceptionsWhy vulnerability and openness create more support than silence and hidingHow a devastating diagnosis can paradoxically become a pathway to deeper self-awarenessWhy This Episode Matters: Whether you're facing cognitive decline yourself, caring for someone with dementia, or simply navigating any major life challenge, this conversation offers a masterclass in how to transform crisis into purpose and fear into connection.This episode will help you:Understand the reality of early-stage Alzheimer's beyond stereotypes and misconceptionsLearn why shame around cognitive decline hurts both patients and familiesNavigate the balance between planning for the future and staying presentBreaking the Silence: Dr. Nelson's decision to openly share his journey began with telling his family, expanded to his professional network, and now includes hundreds of LinkedIn followers who find hope and community in his posts.Dr. Nelson's Mission Statement: "I want to keep showing up. I want to keep gathering people around me. I want to tell the truth about this journey, the funny moments, the frustrating ones, the vulnerable questions. Because if I don't, I fear I'll look up one day and realize I disappeared long before I was actually gone."Connect with Dr. Gregory Nelson:LinkedIn: https://www.linkedin.com/in/gregorypnelson/ Ways that Dr. Adrienne Youdim Can Support You Join the Monthly Free Mind-Body Workshops: Participate in engaging mind-body practices designed to help manage your stress response. Register here. Sign Up for the Newsletter: Stay updated with valuable insights and resources by subscribing to the newsletter. Sign up here. Freebie alert. Register for our monthly free MindBody Workshop and receive a downloadable guide on emotional labeling to help you manage your emotions effectively. Connect with Dr. Adrienne Youdim Website :https://www.dradriennespeaks.com/ Instagram: https://www.instagram.com/dradrienneyoudim/

Liz is back tackling your questions on whether it's ever too late to start HRT, emotional eating habits, unwanted facial hair, and creatine.Liz looks at genetic testing, tinnitus and menopause, and whether it's ever too late to start hormone replacement therapy for Carmel.She also shares strategies to help stop Sue's emotional and binge eating habits from holding her back in midlife.Liz also delves into unwanted facial hair that appears in midlife for Jo and the benefits of creatine for Mitch.Links mentioned in the episode:Lifecode GXBetterYou spray supplements - save 15% with LIZLOVESReduce your risk of Alzheimer's disease, with Patrick HolfordHow EMDR therapy can help heal trauma, with Dr Cheryl CrossTweezerman tweezersFollow Lily Earle on InstagramA Better Second Half by Liz EarleHave a question for Liz? Send a WhatsApp message or voicenote to 07518 471846, or email us at podcast@lizearlewellbeing.com for the chance to be featured on the showPlease note, on some occasions, we earn revenue if you click the links and buy the products, but we never allow this to bias our coverage and always honestly review. For more information please read our Affiliate Policy. Hosted on Acast. See acast.com/privacy for more information.

In this episode, we will learn from Corrin Campbell, BS, COTA/L. Corrin, a COTA for 25 years, has practiced Occupational Therapy in areas from home health, subacute rehab, long term care, outpatient, Geri-psych and more. In every setting, she zeroes in on maximizing each client's level of function. After nearly a decade in the clinical settings, she took on higher education, supporting many students as an instructor, Fieldwork Coordinator, and Program Director. Though she continues to support former students, her true passion is working with persons experiencing changes in cognition. Her desire to stay current with treatment and policy trends has driven her to attend state and local conferences and she is immediate past president of the Connecticut OT Association. She has presented to the Alzheimer's Association and other medical groups on identifying and treating changes in cognition as early as possible. She has also enjoys traveling the state educating those interested in learning how to age and live well!Contact & Resources:To connect with me on a personal level social IG @RinnyOTProfessional/employer socials IG and FB @livewellctlivewell.orgLiveWell - Redefining Dementia Care - LiveWellDementia Friendly, Dementia Capable, and Dementia Positive: Concepts to Prepare for the Futureacademic.oup.comdementiafriendsusa.orgAs always, I welcome feedback & ideas from all of you or if you are interested in being a guest on future episodes, please do not hesitate to contact Patricia Motus at transitionsot@gmail.com or DM via Instagram @transitionsotTHANK YOU for LISTENING, FOLLOWING, DOWNLOADING, RATING, REVIEWING & SHARING “The Uncommon OT Series” Podcast with all your OTP friends and colleagues!Full Episodes and Q & A only available at:https://www.wholistic-transitions.com/the-uncommon-ot-seriesSign Up NOW for the Transitions OT Email List to Receive the FREE Updated List of Uncommon OT Practice Settingshttps://www.wholistic-transitions.com/transitionsotFor Non-Traditional OT Practice Mentorship w/ Patricia:https://docs.google.com/forms/d/e/1FAIpQLSeC3vI5OnK3mLrCXACEex-5ReO8uUVPo1EUXIi8FKO-FCfoEg/viewformHappy Listening Friends!Big OT Love!All views are mine and guests' own.

In this episode, Cathy Sykora welcomes Lyndsey Byrne back to discuss her work as a Cognitive Health Coach, focusing on brain health, dementia prevention, and reversing cognitive decline through the Bredesen Protocol. Lyndsey shares her personal story of helping her mother stabilize Alzheimer's symptoms and explains how this inspired her to dedicate her life to supporting others in similar situations. She outlines the types of clients she works with, the importance of early detection, and the structured yet personalized lifestyle approach she uses to support cognitive health. This episode is rich with insights into the connection between lifestyle and brain function, and how small changes can have a big impact. In this episode, you'll discover: How Lyndsey Byrne's personal experience led her to become a Cognitive Health Coach The key components of the Bredesen Protocol for brain health and dementia prevention Why sugar and toxins in food and personal care products play a critical role in cognitive decline The role of cognitive testing and functional medicine in reversing or preventing dementia How the Apollo Health platform supports clients with actionable, data-driven health reports Strategies to support both individuals experiencing cognitive issues and their caregivers Tools like the Yucca app to make healthier choices in food and personal care products Memorable Quotes: "People think dementia is a death sentence. There's only one direction of travel." "If you can cut out sugar, even if you're not going to do anything else, that is huge." "The amyloid plaque is not the cause of Alzheimer's; it's the brain's way of defending itself." Bio: Lindsey Byrne helps people to improve their brain health and memory, prevent dementia, and even improve symptoms of cognitive decline. She is a Functional Medicine Certified Health Coach (FMCHC) and Certified Re:CODE 2.0 Health Coach. Lindsey supports individuals who want to take a proactive approach to cognitive health, whether due to family history or early signs like brain fog, and uses a personalized, natural, and lifestyle-centered strategy. Mentioned in This Episode: FREE Brain Health Guide Book: What Did I Come in Here For Again? (UK) | US The Cognitive Health Coach Facebook Page Bredesen Support UK Facebook Group LinkedIn – Lindsey Byrne YouTube – The Cognitive Health Coach Apollo Health Practitioner Finder Links to Resources: Health Coach Group Website: thehealthcoachgroup.com Special Offer: Use code HCC50 to save $50 on the Health Coach Group website Leave a Review: If you enjoyed the podcast, please consider leaving a five-star rating or review on Apple Podcasts.

Send us a textThe genetics of sleep duration and sleep timing.Episode Summary: Dr. Ying-Hui Fu discusses her research on the genetics of sleep, focusing on natural short sleepers who thrive on 4-6 hours of sleep and the heritability of sleep traits like duration and timing. She explores how sleep efficiency, rather than just duration, may explain why some need less sleep without health deficits, and delves into the molecular and circadian mechanisms regulating sleep. About the guest: Ying-Hui Fu, PhD is a neuroscientist and professor at UCSF, where her lab studies the genetics of human sleep behaviors, particularly sleep duration and schedule.Discussion Points:Sleep Traits Are Genetic: Sleep duration (how long you sleep) and sleep schedule (when you sleep) are partially heritable, with most people needing 7-9 hours, while rare natural short sleepers thrive on 4-6 hours.Natural Short Sleepers: These individuals fall asleep quickly, have high sleep efficiency, and live healthy, active lives without deficits, possibly due to faster toxin clearance and repair during sleep.Sleep Efficiency Matters: Short sleepers may complete restorative sleep processes (e.g., clearing toxins, repairing damage) more efficiently, allowing them to need less sleep.Circadian & Entrainment Pathways: Sleep timing is regulated by a molecular clock and environmental cues like light, with mutations in entrainment pathways causing extreme schedules (e.g., early bedtime or night owl tendencies).Modern Lifestyle Harms Sleep: Stimuli like blue light and tense media disrupt sleep patterns, leading to widespread sleep deprivation and health risks.Shift Work Risks: Shift workers face higher risks of diseases like cancer and neurodegeneration due to disrupted sleep cycles, though genetic background influences susceptibility.Finding Your Sleep Rhythm: A two-week vacation without stimulants or artificial light can help determine your natural sleep schedule and duration.Sleep's Health Impact: Poor sleep is a major factor in aging and diseases like Alzheimer's, making it as critical as diet and exercise for health.Related episode:M&M 237: Circadian Biology: Genetics, Behavior, Metabolism, Light, OxygenSupport the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

Episode 2669 - BEST OF: Vinnie Tortorich welcomes Dr. Mary Newport back to the show, and they discuss brain health and coconut oil, ketones, and her upcoming book. https://vinnietortorich.com/2025/07/brain-health-coconut-oil-dr-mary-newport-episode-2669 PLEASE SUPPORT OUR SPONSORS YOU CAN WATCH ALL THE PODCAST EPISODES ON YOUTUBE -  BRAIN HEALTH AND COCONUT OIL Vinnie welcomes Dr. Mary Newport back to the show, and they start the show by discussing Mary's husband's early-onset dementia. (1:20) At age 56, her husband was experiencing a rapid decline in brain health. After some challenges, he became eligible for a clinical trial for Alzheimer's treatment. (9:00) She had heard about the benefits of ketones and coconut oil and started experimenting. (12:15) It's amazing the improvements they saw in a short amount of time! Vinnie mentions his battle with leukemia and how staying in ketosis has kept him in remission. (16:40) Mary mentions that people with epilepsy who have been on a ketogenic diet will have recurrence of seizures after having just a piece of cake; consequently, this is called "Birthday Syndrome". (20:40) Vinnie asks Mary her opinion on exogenous ketone esters and salts. (25:00) They discuss further the benefits of coconut oil, and Mary also started using it and feels like her mental endurance has improved. (28:40) Mary mentions that coconut oil got a bad rap because companies that created hydrogenated oils were competing with it and creating a negative campaign against it. (38:30) They also discuss how the dietary guidelines still used today are based on incorrect information from the 1950s. (41:00) Saturated fats are not the problem. They chat about cholesterol, plaque, and inflammation. CLEARLY KETO They turn the conversation to Mary's upcoming book: "". Mary lists some of the topics covered in her book, from the problem of too much sugar, ketones, fasting, your brain on coconut oil, and much more. Vinnie and Mary discuss various medications, how some do (and don't) function, and how some only "keep you perfectly sick". (55:00) Vinnie talks about how he knows of cases where people were on 3 medications for one issue, but that issue could be resolved just by proper eating. Mary talks about how even she, at one time, was unaware of how the current low-fat dietary guidelines were bad; consequently, she has changed her eating habits and has seen many benefits. It is possible to overcome insulin resistance, which can also include virgin coconut oil. (1:04:20) Insulin resistance affects brain functions and other functions in the body. She talks about some things she has learned about brain plaque and how it behaves. (1:17:00) Mary mentions other topics addressed in the book and lets us know an update about her husband. They talk a little more about coconut oil, and how it's difficult to get people to accept that it is as good! Go to for more suggestions and information. More News If you are interested in the NSNG® VIP group is currently closed for registration, but you can get on the wait list - Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel.  “Dirty Keto” is available on Amazon! You can purchase or rent it . Make sure you watch, rate, and review it! Eat Happy Italian, Anna's next cookbook, is available!  You can go to  You can order it from .  Anna's recipes are in her cookbooks, website, and Substack–they will spice up your day!  Don't forget you can invest in Anna's Eat Happy Kitchen through StartEngine.  Details are at Eat Happy Kitchen.  There's a new NSNG® Foods promo code you can use! The promo code ONLY works on the NSNG® Foods website, NOT on Amazon. https://nsngfoods.com/   PURCHASE  DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere:  Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere:  REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere:  FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: