Podcasts about Diazepam

As a neurological emergency, status epilepticus (SE) requires timely diagnosis and treatment. A US study found that 10% of people with SE were not diagnosed by emergency services. Among those who were diagnosed in an ambulance, 20% did not receive any first-line treatment, while others received lower-than-recommended doses. Sharp Waves spoke to senior author Dr. Elan Guterman about the study.Publications mentioned during the conversation:Status Epilepticus Identification and Treatment Among Emergency Medical Services Agencies  JAMA Neurology A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus | New England Journal of MedicineParamedic-Identified Enablers of and Barriers to Pediatric Seizure Management: A Multicenter, Qualitative Study: Prehospital Emergency CareEmergency response to out-of-hospital status epilepticus | Neurology Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.Let us know how we're doing: podcast@ilae.org.The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Instagram, and LinkedIn.

CITR's 24 Hours of Radio Art in a snack-sized format. Dark Ambient. Drone. Field Recordings. Noise. Sound Art. Or something. This evening's broadcast features new music by E.U.E.R.P.I., SABA ALIZADEH, 400 LONELY THINGS, HAAi, DRIFT, and GAUDENZ BADRUTT.

A Clinician's guide to TMD Management Walkthrough of the latest TMD Guidelines with the authors! What's the right approach when a patient presents with both acute and chronic painful jaw symptoms? How can the latest RCS guidelines simplify your diagnosis and treatment process? In this episode, Professor Justin Durham and Mrs. Emma Beecroft join Jaz to unpack the latest Royal College of Surgeons TMD guidelines designed specifically to help GDPs navigate these tricky cases. Together, they explore practical strategies for managing TMD, breaking down the step-by-step flowchart that makes handling these cases less intimidating. From understanding the key principles to applying them in everyday practice, this episode will help you feel more confident in delivering better patient care for TMD. https://youtu.be/R0NaBJr5g5E Watch PDP213 on Youtube Protrusive Dental Pearl: Important takeaway: Download the New TMD Guidelines  The folder includes: A patient version of the guidelines A dentist version of the guidelines The full guidelines document Video of delivering an equilibrated soft bite guard using heat technique Key Takeaways: The guidelines for TMD are designed to simplify diagnosis and treatment. Self-management is crucial for TMD patients and can lead to better outcomes. Understanding the difference between muscle and joint pain is essential in TMD management. Early intervention in TMD can lead to significant improvements for patients. The importance of patient-centered care in managing TMD effectively. TMD is a common issue that requires a collaborative approach among dental professionals. The role of pain management in TMD is about improving quality of life, not just curing the condition. Continuous education and training are vital for dental professionals dealing with TMD. Understanding the pathogenesis of TMD is crucial for effective treatment. Stabilization splints can provide relief but should be used judiciously. Effective communication can significantly impact patient pain experiences. Tailoring treatment to individual patient needs is vital. Highlights for this episode: 00:48 Protrusive Dental Pearl 05:20 Introducing the Guests: Prof. Justin Durham and Mrs. Emma Beecroft 13:05 Stigma and Complexity of TMD in Dentistry 17:01 Challenges of Navigating TMD Treatment Perspectives 22:07 Diagnosing TMD: Tools and Techniques 27:09 Simplified Approach to TMD Examination 30:54 Muscle Palpation Pressure  32:20 Acute Limited Opening: Muscle vs. Joint Origin 40:20 Diazepam for Acute Myogenous TMD 54:58 Debating Soft vs. Stabilization Splints 57:17 Patient-Centered TMD Management 01:09:28 Conclusion and Resources This episode is eligible for 1 CE credit via the quiz on Protrusive Guidance.  This episode meets GDC Outcomes B and C. AGD Subject Code: 200 OROFACIAL PAIN (Diagnosis and treatment) Dentists will be able to - Explore the varied approaches to TMD care and how to align them with evidence-based practices. Emphasize the importance of self-management strategies and their role in improving patient outcomes. Advocate for a patient-centered approach, focusing on listening, communication, and individualized care plans. If you loved this episode, be sure to check out this episode: TMD Full Exam with ‘The TMJ Doc' Dr Priya Mistry – PDP064

This week on Dopey! After years of Pursuit we finally got chemist, author, TV host, Documentarian and Director - Hamilton Morris of Vice and HBO's trailblazing show Hamilton's Pharmacopia to come to my Dad's house! He tells of how he became a PSYCHONAUT and also why he hates the term PSYCHONAUT among tons of other stuff psychedelic and chemical.  PLUS Adversity Advantage host Doug Bopst is back to talk New Years Resolutions, fitness and more! On this brand new episode of the good old Dopey Show! There are a few Dopeywood Tickets left: https://buytickets.at/thedopeyfoundation/1484803 Join Patreon at: https://www.patreon.com/dopeypodcast Here is what AI said: Dopey Podcast Episode Show Notes:

This Week In Culture Episode 418: Diazepam (#ReasonableDoubt S2 Ep9). This week Ant and J. Johnson break down the penultimate episode of #ReasonableDoubtHulu. The guys discuss Shanelle taking the stand, JT's mother and more! Stream the latest podcast now!!   --- Support this podcast: https://podcasters.spotify.com/pod/show/thisweekinculture/support

Esta nueva temporada empezamos las biografías con un guapo de Antes: Alain Fabien Maurice Marcel Delon-Arnold, más conocido como Alain Delon, Alain Deleonardo en español latino. El pequeño Alain nació el 8 de noviembre de 1935 en el barrio de Sceaux, en los Altos del Sena, que antes estaba en París, pero no en París, París, si no en Puertatierra. Lo bueno de haber nacido en esa época era que podías bañarte en el río sin miedo de acabar como Schwarzenegger en Terminator 2. Sus padres fueron Fabien Delon, director de un pequeño teatro de barrio, y Édith Arnold, farmacéutica, por eso cariño, no mucho, pero melatonina pa dormirlo tempranito, ni contando las gotas. Ahí, a chorro. Cuando Alein tenía 4 años sus padres se divorciaron y el niño parecía una carta certificá de hacienda, no lo recogieron ni los abuelos, así que al pobre acabó dado en adopción. Al morir sus padres adoptivos, Fabien y Édith (sus padres biológicos) se hicieron cargo de la custodia compartida, y ya que ambos se habían vuelto a casar y habían tenido más hijos, Alain tendría por fin una vida familiar. PO TAMPOCO. Al niño lo llamaban “el millón”, que tó´r mundo lo quería pero nadie lo guardaba en su casa. Así fue como Alein Delon acabó en un internado católico, una muy buena idea con la carita que tenía el niño, pero menos mal que lo echaron por “comportamiento rebelde”. Dejó la escuela a los 14 años y se puso a trabajar en la carnicería de su padrastro, otra magnífica idea con la infancia que le habían dado a la criaturita, que fue un milagro que no se convirtiera, yo qué sé, en Jeffrey Dahmer, Jack, el descuartizador o Pitingo versionando “Killing me softly”. A los 17 años se alistó en la Marina Francesa, llegando a participar en la guerra de Indochina y licenciándose con deshonor en 1956, que pa que te toque ir a una guerra y te licencien con deshonor, ya te has tenido que mover tú menos que la parrilla de Canal Sur. Como de marinero no lo querían ni en Elcano pa escondé la droga, tuvo que buscarse la vida trabajando de camarero, de vendedor, de secretario, de portero, llegándose incluso a relacionar con el hampa parisina hasta que conoció a la actriz Brigitte Auber que se lo llevó de acompañante a Cannes. Er tío era tan guapo y tenía un cuerpazo tan espectacular que se bloqueaba hasta arco de seguridad, que pitaba na más que pa que volviera a pasar. Allí un productor americano le dijo que aprendiera inglés que lo iba a hacer más famoso que al Diazepam, pero al regresar a Francia conoció a un director francés que le dijo que no, que se fuera con él mejor, que el americano le iba a hacer lo mismo que Sardá al Pozí. Y de esa manera fue como Delon, con menos formación que el ejército de Luxemburgo, debutó en su propio país en 1957 con el film “Quand la Femme S'en Mêle”, la historia desgarradora de una mujer con incontinencia urinaria. En 1958 conoció en una película a Romy Schneider, la María de las Mercedes de los bávaros, y se enamoraron mu fuerte hasta 1963, que casualmente es el año con el que tuvo un romance con una cantante alemana que a los 9 meses tuvo un hijo con tó la cara de Delon. En 1964 se casó con Nathalie Cánovas con quien tuvo a su hijo Anthony Delon y de quien se separó en 1968. A tó esto, él seguía haciendo películas, lo contrató la MGM, se fue a Hollywood, vamos, que le cundía la vida a este hombre más que 20€ en AliExpress. En esta época siempre estaba más moreno que Alfonso Arús, fumaba con el cigarro caío, que eso era fumar sexy antes y miraba a cámara como yo miro las ofertas de los donuts rellenos de chocolate. No había quien escapara de sus encantos y si no que se lo pregunten a Mick Jagger cuando se sentó con su pareja, la actriz y cantante Marianne Faithfull, en un sofá en el que Delon estaba fumando con el cigarro caío. En 1968, durante el rodaje de “La piscina”, un tórrido thriller psicológico dónde siempre aparecían cogidas las mejores hamacas pero nunca las ocupaba nadie, el amigo y guardaespaldas de Delon, Stevan Markoviç, apareció muerto en un basurero cerca de París con un papelito en la mano que ponía “Si me matan, la culpa es de A. Delon” porque por lo visto el Esteban sabía que Delon gustaba de hacer fiestas con corpiños rojos y mucha gente. Pero la policía nunca pudo descubrir quién podía ser el tal A.Delon. En 1969 se separó de Nathalie y se casó con una actriz francesa, no se le fuera a quedar chico el traje de novio y tuviera que comprarse otro. Aunque se definía a sí mismo como gaullista, que rechazan el capitalismo para construir una tercera vía social, er gashó se hartó de comprar cosas de más de 100€ que alcanzarían el valor de 275 millones de $. En 1987 se volvió a casar, esta vez con una actriz y escritora holandesa con quien tuvo 2 hijos más y de la que se separaría en 2002. 3 años antes, en 1999 obtuvo la nacionalidad suiza, que con todo el dinero que había juntao lo que no sé es cómo no se compró Suiza. A tó esto Alain Delon siguió rodando películas, más en francés porque en inglés tenía más acento que el candelabro de La Bella y La Bestia. En 2019 sufrió un ictus severo por lo que solicitó la eutanasia, pero como se recuperó por completo, lo dejó pa un poquito más pa'lante. En 2023, por si acaso, decidió venderlo tó en el Cambalache pa que los niños no se le pelearan por la herencia. Desgraciadamente, el pasado 18 de agosto de este 2024, nos dejaba para siempre el “Batman” Delon aunque ustedes siempre podrán recordarlo cada vez que se gasten 20€ en AliExpress o vean a alguien fumar con el cigarro caío.

Conversamos con Pedro Tonantzin –periodista de Sur Digital– en cuanto al comisionado de Seguridad Pública de Morelos, José Antonio Ortiz Guarneros, que descartó que el Obispo Emérito de Chilapa-Chilpancingo, Salvador Rangel, haya sido víctima de un secuestro exprés; pues hay evidencia de que entró por su propia voluntad a un motel en Cuernavaca, en compañía de un hombre. El examen toxicológico del Hospital General "José Parres" arrojó la presencia de cocaína y benzodiacepina, generalmente presente en medicamentos como Diazepam, y que sirve para contrarrestar los efectos de la cocaína. Además, informes policiacos señalan que el obispo Salvador Rangel fue encontrado en el Hotel Real Ocotepec de Cuernavaca y de ahí fue trasladado al Hospital General “José Parres” en calidad de desconocido.Programa transmitido 02 mayo de 2024. Escucha Esto no es un noticiero con Nacho Lozano, en vivo de lunes a viernes de 1:00 p.m. a 2:00 p.m. por el 105.3 de FM. Esta es una producción de Radio Chilango.

Welcome to this special episode of the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. For major FDA decisions in the field of neurology, we release short special episodes to offer a snapshot of the news, including the main takeaways for the clinical community, as well as highlights of the efficacy and safety profile of the agent in question. In this episode, we're covering the recent approval of diazepam buccal film (Libervant; Aquestive Therapeutics) for the treatment of pediatric patients with intermittent, stereotypic episodes of frequent seizure activity (seizure clusters, acute repetitive seizures). Indicated for those between 2 and 5 years of age, the therapy offers patients a compact, easily administered diazepam formulation. The FDA previously granted tentative approval in August 2022 for Libervant for treatment of these patients with epilepsy 12 years of age and older, with U.S. market access for Libervant for this age group of patients subject to the expiration of the existing orphan drug market exclusivity of a previously FDA approved drug scheduled to expire in January 2027. Following the approval, Michael Rogawski, MD, PhD, a distinguished professor of neurology and pharmacology at the University of California Davis Health Medical Center, provided insight on what the decision means for patients and clinicians. Rogawski gave comment on the significance of having a new administration route for diazepam, the safety and feasibility of diazepam buccal film, and some of the major points of emphasis from its clinical program. For more of NeurologyLive's and Contemporary Pediatrics coverage of diazepam buccal film's approval, head here: FDA approves diazepam for seizure clusters in patients 2 to 5 years Episode Breakdown: 0:20 – Diazepam buccal film approved for intermittent seizures in pediatrics 2:00 – Michael Rogawski, MD, PhD, giving reaction to the approval 4:10 – Flexibility with multiple diazepam administration routes 6:55 – Rogawski on the safety of diazepam buccal film amid high need 12:30 – Notable takeaways from the diazepam buccal film trial program Thanks for listening to the NeurologyLive Mind Moments podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Today I noticed that yes, a song on my Ren Gill playlist really was called "Diazepam." And yes, it's about the antidepressant/benzodiazepine of the same name. The song, like may of Ren's, is all about his struggles with it and with everything else. The creative lesson I took from this Noticing is the importance of drawing from personal experiences and emotions in creative expression. Being fully yourself — fully real — really is the secret sauce, and forms an amazing connection with the audience.WANT MORE?Members get extra episodes of the podcast, extra companion blog posts (see below), and more every week … all for the price of a fancy coffee. Learn about membership here.Prefer reading?Listening to the Art of Noticing podcast is only one way to get these lessons. Every episode of the podcast also has a complete companion blog post, all of which you can find here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit johnnybtruant.substack.com/subscribe

Sara Jane Harris and Dr. James Michael Ryan meet at his dental practice in the Fall of 2020. By the Summer of 2021, Harris is not only working for the oral surgeon but also living with him. Sarah Harris' family members began to notice a change in her physical appearance. The family says Harris did not look healthy, and in the following months, Harris' growing drug addiction became evident. What's more, the family believes Ryan was giving his girlfriend drugs from his practice. First responders rush to Ryan's home after an overdose call. Inside, paramedics find Sarah Harris, unresponsive. Various vials of controlled substances, like Ketamine, Diazepam, and Propofol are nearby. Davis weighs just 83 pounds. Ryan is charged in Harris' death, accused of providing the drugs that killed her. According to court documents, text messages between Ryan and Harris show Harris asking for different drugs. Ryan has now been convicted of murdering his girlfriend after she overdosed. The jury's verdict was rendered in less than three hours. Joining Nancy Grace Today: Ken Belkin - Criminal Defense Attorney; Twitter: @Kenneth_Belkin Dr. Angela Arnold – Psychiatrist, Atlanta, GA; Expert in the Treatment of Pregnant/Postpartum Women; Former Assistant Professor of Psychiatry, Obstetrics and Gynecology: Emory University; Former Medical Director of The Psychiatric Ob-Gyn Clinic at Grady Memorial Hospital; Voted “My Buckhead's Best Psychiatric Practice of 2022” Dr. William Morrone  – Chief Medical Examiner, Bay County Michigan; Author: “American Narcan: Naloxone & Heroin-Fentanyl Associated Mortality” Robert Crispin – Private Investigator, Former Federal Task Force Officer for United States Department of Justice, DEA and Miami Field Division; Former Homicide and Crimes Against Children Investigator, “Crispin Special Investigations;” Facebook: Crispin Special Investigations, Inc. Lindsay Watts - Emmy-Winning Reporter, FOX 5 DC; Twitter: @LindsayAWatts, Instagram: @LindsayWatts; Podcast: "Siege on Democracy" Learn more about your ad-choices at https://www.iheartpodcastnetwork.comSee omnystudio.com/listener for privacy information.

Garza sits down in-person with French / English band TEN56. https://www.linktr.ee/ten56 TEN56. is: Aaron Matts - Vocals Quentin Godet - Guitar Luka Rozaka - Guitar Steeves Hostin - Bass Arnaud Verrier - Drums CHAPTERS: 00:00 - Hating the Sound of Your Own Voice 01:11 - Aftershock Festival & Louder Than Life 02:14 - Starting Over In a New Band & Having a Fresh Perspective 09:00 - Leaving Betraying the Martyrs 17:49 - Playing First Show in 2022, Growing Quickly as a Band 19:40 - Luka & Chris Look Like the Hardy Boys 22:47 - Garza vs Robert Trujillo Net Worth 25:10 - Health Insurance is Free in Europe, Aaron's Gallbladder Removal 29:45 - U.S. Restrooms vs European 32:54 - “Downer” 35:22 - Home Venue in France 37:10 - Ten56 Unique Tunings & Sound 39:54 - How Ten56 Found Their Sound 43:25 - The Band Being a Labor of Love, Letting Go of Pressure 47:52 - Vola Guitars & Best Pickups for Metal 53:29 - Songwriting Process, No Compromise on Heaviness 57:53 - Merch Cuts & Taxation 1:03:53 - Being Lifers, Missing Out On Friend & Family Time 1:10:42 - Depression & Meaning Behind the Song, “Diazepam” 1:15:25 - 1st U.S. Tour with Attila

Stacie Czech founded Thryv Organics after years of helping her mother manage her autoimmune disease, Multiple Sclerosis. The experience taught her that there had to be a better way. After learning about and using CBD products and seeing the results, she knew she needed to help others find the relief her mother found. Thryv Organics code ASHLEY25 12:25: Why third party testing is important 12:52: Chernobyl & hemp (WHY organic matters!!!) 13:43: Hempcrete instead of dry wall 14:09: Dr Rachel Knox TED Talk 20:45: Difference among broad spectrum, full spectrum, and isolate CBD 22:45: Pregnancy, breastfeeding, and CBD 26:13: Michael Crawley 26:19: Dr Kadile | Coimbra Protocol (high dose vitamin D protocol) 31:21: Swap wine for CBD gummies 32:18: Menopause + CBD + THC 46:00: Prioritize your own wellness Instagram Facebook Tik Tok Thryv Organics Website Stacie's Mom was on Gabapentin, Diazepam, Methocarbamol, Tramadol, and Trazodone BONUS material: Dr. Terry Wahls reverses her MS

En entrevista con Pamela Cerdeira, para MVS Noticias,  la periodista, Yohali Reséndiz en su sección ´´ Periodismo a toda prueba' nos presentó su investigación sobre una maestra que drogó con Diazepam a alumno de 2 años y 3 meses para dormirlo.See omnystudio.com/listener for privacy information.

Chilpancingo: ¿Qué hay detrás de la crisis de violencia que se vive en Guerrero?, Lluvias en la CDMX continuarán, de fuertes a moderadas, por lo menos toda la semana, Así es la enorme esfera que se colocó en Las Vegas, Crisis hídrica en Uruguay: "Estamos tomando agua salada", ¿Cómo integrar la tecnología a un plan de seguridad nacional?, Denuncian a maestra que drogó con Diazepam a alumno de 2 añosSee omnystudio.com/listener for privacy information.

Visit: https://nursing.com/140meds to request your free copy of "140 Must Know Meds" Generic Name Diazepam Trade Name Valium Indication Anxiety, pre-op sedation, conscious sedation, treatment of seizures, insomnia, management of alcohol withdrawal Action Decreases the effects of voltage gated sodium channels to depresses the CNS Therapeutic Class Antianxiety agents, anticonvulsants, sedative/hypnotics, skeletal muscle relax- ants (centrally acting) Pharmacologic Class Benzodiazepine Nursing Considerations • Contraindicated in hepatic dysfunction • Use caution with renal impairment • Can cause dizziness, drowsiness, lethargy, hypotension, physical depen- dence, tolerance • Instruct patient to take as directed • Caution to avoid alcohol use • Flumazenil (Romazicon) is the reversal agent

¡Welcome una vez más a tu loco pódcast! El día de hoy Kiki y Martha te cuentan sobe la extrana muerte de Cindy James, despues de anos de acoso, acompáñanos y si te gustan las historias de TRUE CRIME que contamos en este pódcast no olvides seguirnos en redes y dejarnos tus comentarios que son de gran ayuda. 🎧¿Ya escuchaste el episodio?🗣👂🎧 .DALE AL BOTÓN DE SUSCRIBIR Y DEJANOS TU ❤ . 💙NECESITAS DIFUNDIR UN CASO EN ESPECIFICO EN NUESTRO SEGMENTO HASTA ENCONTRARTE? LLENA ESTE FORMULARIO https://docs.google.com/forms/d/e/1FAIpQLSfmqf4_3d5Sa-uiDNSLYEQPVpxyWjqFHgAJlLFYQOT_UdsDKQ/viewform?usp=sf_link 🖤Tik Tok: https://www.tiktok.com/t/ZTdEG76KJ/ . 💙Facebook: https://www.facebook.com/JuegoDeAsesinosPod . ❤Instagram: https://www.instagram.com/juegodeasesinos_podcast/ . ❤Instagram Martha: https://www.instagram.com/mar.tham/ ❤Instagram Kiki: https://www.instagram.com/kikive72/ . 💙Telegram: https://t.me/+DYdsmL2WjJM1YjY5 . TIENDA DE MERCANCÍA👕👜🧢👚😷!! Juegodeasesinos.threadless.com . 💟¿Eres fan apasionado de nuestro podcast y quieres más episodios? Esta todo en nuestra opción de mesenas!! PATREON: https://patreon.com/Juegodeasesinospodcast?utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=creatorshare_creator&utm_content=join_link IVOOX PREMIUM ANUAL: https://www.ivoox.vip/premium?affiliate-code=72e775b4b349b7b9715016d4520cebc7 .IVOOX PREMIUM MENSUAL: The leading podcast platform in Spanish - iVooxIVOOX PLUS: The leading podcast platform in Spanish - iVoox. LINK GENERAL: https://linktr.ee/Juegodeasesinospodcast . Fuentes: https://unsolved.com/gallery/cindy-james/ https://en.wikipedia.org/wiki/Death_of_Cindy_James https://allthatsinteresting.com/cindy-james https://storiesoftheunsolved.com/2022/01/25/the-death-of-cindy-james/ https://en.wikipedia.org/wiki/Diazepam https://en.wikipedia.org/wiki/Flurazepam https://unsolved.com/gallery/cindy-james/ https://unsolvedmysteries.fandom.com/wiki/Cindy_James https://allthatsinteresting.com/cindy-james https://www.grunge.com/926452/the-chilling-death-of-cindy-james-is-still-a-mystery/ https://www.mamamia.com.au/cindy-james-cause-of-death/ https://www.lipstickalley.com/threads/mystery-of-cindy-james-stalked-for-7-years-or-just-crazy.4287745/

¡Welcome una vez más a tu loco pódcast! El día de hoy Kiki y Martha te cuentan sobe la extrana muerte de Cindy James, despues de anos de acoso, acompáñanos y si te gustan las historias de TRUE CRIME que contamos en este pódcast no olvides seguirnos en redes y dejarnos tus comentarios que son de gran ayuda.

In this episode Sal, Adam & Justin speak with peptide expert, Dr. William Seeds. A brief background of Dr. Seeds. (2:34) What are peptides? (4:09) Did he see the writing on the wall? (7:13) What makes them different from drugs? (8:44) How hormones are psychologic. (13:58) The biggest issue he sees with people's inability to lose weight. (20:30) How peptides can influence fat loss. (24:30) The benefits and science behind GLP-1 receptor agonists. (27:08) Improving muscle mass to save lives. (30:22) Why diet is so crucial when it comes to weight loss. (34:02) What GHRHs (Growth hormone-releasing hormones) do and how they can impact fat loss. (41:23) If you're not doing resistance training, why are you training then? (48:38) The most beneficial peptides for “most” people. (51:47) The importance of going through a doctor when using peptides. (1:02:29) Life is handled in the weight room. (1:07:09) Related Links/Products Mentioned For Mind Pump listeners only Equi.life is offering a FREE BOTTLE of their best-selling liquid Vitamin D3 going on right now. Special Promotion: MAPS Anabolic Advanced Launch for only $97! **Code AA60 at checkout** (Ends February 26th, 2023) February Promotion: MAPS Performance, MAPS Aesthetic, and MAPS HIIT are all 50% off! **Code FEB50 at checkout** MP Hormones Mind Pump Hormones Facebook Private Forum GLP-1 agonists: Diabetes drugs and weight loss - Mayo Clinic Semaglutide – The International Peptide Society FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014 Growth Hormone-Releasing Peptides (GHRP) Deep Dive Sermorelin Dosage Calculator and Guide | What You Must Know AMPK: guardian of metabolism and mitochondrial homeostasis The Resistance Training Revolution – Book by Sal Di Stefano BPC-157 Benefits | What You MUST Know The extracellular matrix and cell wall (article) | Khan Academy Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats P-1114 - Rapid and slow response during treatment of generalized anxiety disorder with peptide anxiolytic selank Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells Mind Pump Free Resources     Mind Pump Podcast – YouTube Featured Guest Website – Dr. William Seeds  

Status Epilepticus is one of the most common pediatric neurologic emergencies and requires prompt, targeted treatment to reduce patient morbidity and mortality. On this podcast, Pediatric Critical Care Physician, Dr. Renuka Mehta, Pediatric Resident Physician, Dr. Yvonne Ibe, and medical student, Emily Austin will discuss management for status epilepticus and rapid interventions that can be potentially lifesaving—because in seizure management, time is brain.  FREE CME Credit (requires sign-in):  Link Coming Soon! Thank you for listening to this episode from the Department of Pediatrics at the Medical College of Georgia. An additional thanks to Dr. Lorna Bell, Dr. George Hsu, and Dr. Rebecca Yang who provided editing and peer review of today's discussion. If you have any comments, suggestions, or feedback- you can email us at mcgpediatricpodcast@augusta.edu Remember that all content during this episode is intended for educational purposes only. It should not be used as medical advice to diagnose or treat any particular patient. Clinical vignette cases presented are based on hypothetical patient scenarios. Thank you for your support! References: Alldredge, B. K., Gelb, A. M., Isaacs, S. M., Corry, M. D., Allen, F., Ulrich, S., Gottwald, M. D., O'Neil, N., Neuhaus, J. M., Segal, M. R., & Lowenstein, D. H. (2001). A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(9), 631–637. https://doi.org/10.1056/NEJMoa002141  Chamberlain, J. M., Kapur, J., Shinnar, S., Elm, J., Holsti, M., Babcock, L., Rogers, A., Barsan, W., Cloyd, J., Lowenstein, D., Bleck, T. P., Conwit, R., Meinzer, C., Cock, H., Fountain, N. B., Underwood, E., Connor, J. T., Silbergleit, R., Neurological Emergencies Treatment Trials, & Pediatric Emergency Care Applied Research Network investigators. (2020). Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. Lancet (London, England), 395(10231), 1217–1224. https://doi.org/10.1016/S0140-6736(20)30611-5  Chamberlain, J. M., Okada, P., Holsti, M., Mahajan, P., Brown, K. M., Vance, C., Gonzalez, V., Lichenstein, R., Stanley, R., Brousseau, D. C., Grubenhoff, J., Zemek, R., Johnson, D. W., Clemons, T. E., & Baren, J. (2014). Lorazepam vs Diazepam for Pediatric Status Epilepticus: A Randomized Clinical Trial. JAMA, 311(16), 1652. https://doi.org/10.1001/jama.2014.2625  Chen, J., Xie, L., Hu, Y., Lan, X., & Jiang, L. (2018). Nonconvulsive status epilepticus after cessation of convulsive status epilepticus in pediatric intensive care unit patients. Epilepsy & Behavior: E&B, 82, 68–73. https://doi.org/10.1016/j.yebeh.2018.02.008  Fine, A., & Wirrell, E. C. (2020). Seizures in Children. Pediatrics in Review, 41(7), 321–347. https://doi.org/10.1542/pir.2019-0134  Glauser, T., Shinnar, S., Gloss, D., Alldredge, B., Arya, R., Bainbridge, J., Bare, M., Bleck, T., Dodson, W. E., Garrity, L., Jagoda, A., Lowenstein, D., Pellock, J., Riviello, J., Sloan, E., & Treiman, D. M. (2016). Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Currents, 16(1), 48–61. https://doi.org/10.5698/1535-7597-16.1.48  Hanhan, U. A., Fiallos, M. R., & Orlowski, J. P. (2001). Status epilepticus. Pediatric Clinics of North America, 48(3), 683–694. https://doi.org/10.1016/s0031-3955(05)70334-5  Kapur, J., Elm, J., Chamberlain, J. M., Barsan, W., Cloyd, J., Lowenstein, D., Shinnar, S., Conwit, R., Meinzer, C., Cock, H., Fountain, N., Connor, J. T., Silbergleit, R., & NETT and PECARN Investigators. (2019). Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. The New England Journal of Medicine, 381(22), 2103–2113. https://doi.org/10.1056/NEJMoa1905795  Lyttle, M. D., Rainford, N. E. A., Gamble, C., Messahel, S., Humphreys, A., Hickey, H., Woolfall, K., Roper, L., Noblet, J., Lee, E. D., Potter, S., Tate, P., Iyer, A., Evans, V., Appleton, R. E., Pereira, M., Hardwick, S., Messahel, S., Noblet, J., … Hobden, G. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. The Lancet, 393(10186), 2125–2134. https://doi.org/10.1016/S0140-6736(19)30724-X  Raspall‐Chaure, M., Chin, R. F. M., Neville, B. G., Bedford, H., & Scott, R. C. (2007). The Epidemiology of Convulsive Status Epilepticus in Children: A Critical Review. Epilepsia, 48(9), 1652–1663. https://doi.org/https://doi.org/10.1111/j.1528-1167.2007.01175.x  Riviello, J. J., Ashwal, S., Hirtz, D., Glauser, T., Ballaban-Gil, K., Kelley, K., Morton, L. D., Phillips, S., Sloan, E., Shinnar, S., American Academy of Neurology Subcommittee, & Practice Committee of the Child Neurology Society. (2006). Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology, 67(9), 1542–1550. https://doi.org/10.1212/01.wnl.0000243197.05519.3d  Sánchez Fernández, I., Abend, N. S., Agadi, S., An, S., Arya, R., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Gaillard, W. D., Glauser, T. A., Goodkin, H. P., Kapur, K., Mikati, M. A., Peariso, K., Ream, M., Riviello, J., Tasker, R. C., & Loddenkemper, T. (2015). Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology, 84(23), 2304–2311. https://doi.org/10.1212/WNL.0000000000001673  Trinka, E., Cock, H., Hesdorffer, D., Rossetti, A. O., Scheffer, I. E., Shinnar, S., Shorvon, S., & Lowenstein, D. H. (2015). A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 56(10), 1515–1523. https://doi.org/10.1111/epi.13121  Welch, R. D., Nicholas, K., Durkalski-Mauldin, V. L., Lowenstein, D. H., Conwit, R., Mahajan, P. V., Lewandowski, C., Silbergleit, R., & Neurological Emergencies Treatment Trials (NETT) Network Investigators. (2015). Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia, 56(2), 254–262. https://doi.org/10.1111/epi.12905 

In this podcast episode, epileptologists Aatif Husain, MD, and John Stern, MD, have a conversation about rescue therapies and how they fit into the spectrum of epilepsy management. Their discussion begins with sharing what they consider the utility of rescue therapies to be in the overall spectrum of epilepsy. As the conversation goes on, they address the role of rescue therapies in more specific patient populations, such as the newly diagnosed patient, a patient experiencing seizure clusters, and patients who may be experiencing either very few or relatively many breakthrough seizure events. In all scenarios, the experts relate the use of rescue therapies as “insurance”—hoping that the agents don't have to be used, but having them available as coverage in the worst-case scenario. The podcast goes on to discuss rescue therapies in terms of available routes and mechanisms of action and practical strategies for talking to patients about these agents. Rounding out the episode, Drs Husain and Stern express their hopes for future developments in epilepsy management.Presenters:Aatif Husain, MDProfessorDivision of Epilepsy, Sleep and Clinical NeurophysiologyDepartment of NeurologyDuke University Medical CenterDurham, North CarolinaJohn Stern, MDProfessorNeurologyGeffen School of Medicine, UCLADirectorEpilepsy Clinical ProgramUCLA Department of NeurologyLos Angeles, CaliforniaThis content is based on a CE/CME program supported by an independent educational grant from Neurelis, Inc.For additional activities in this program, visit https://bit.ly/3GiLlu4.

Trade: Valium Class: BenzodiazepineMOA: Binds to the benzodiazepine receptor and enhances the effects of GABAIndications: Anxiety, Skeletal muscle relaxation, anticonvulsant Contraindications: Children younger then 6 months, acute angle glaucoma, CNS depression, alcohol intoxication. Side effects:  Respiratory depression, drowsiness, fatigue, headache, pain at the injection site, confusion, nausea, hypotension, cardiac arrest at high doses•Dosing:Adult: Anxiety: 2-10mg IV/IMSeizure: 5-10mg IV/IOPediatric:Anxiety: 0.2 – 0.3mg/kg IV/IMSeizure:  Older then 5 years: 1mg IV/IOOlder then 30 days less then 5 years: 0.2 to 0.5mg IV/IO                Neonate: 0.1-0.3mg/kg IV/IO

Shortest time between two dates Ivan Ariseguieta Will Peking Duk help with our mural? Christmas Hampering Believe It Or Not See omnystudio.com/listener for privacy information.

Shortest time between two dates Ivan Ariseguieta Will Peking Duk help with our mural? Christmas Hampering Believe It Or Not

#RealNews According to the official report: "There was no evidence that drugs or alcohol contributed to the cause of the crash; however, Diazepam (Valium) was detected in Graham's system in post-accident toxicology test. The FAA considers an open prescription for diazepam disqualifying for medical certification and states that pilots using Diazepam should not fly as it may "impair cognitive and psychomotor performance." In other words, he shouldn't have been flying. Now, I'll be victimized and attacked for pointing out the obvious.

Wojciech Zaremba chats with Lexman about the side effects of diazepam, the mythical creature known as an inch-buster and the deadly copperheads of the south.

Join Bespin and Nick this week as they chat The Acolyte plot leaks, the Andor trailer and delay, Batgirl and Scoob! getting cancelled, rumours of HBO Max folding into Discovery+, make their Mavrel starting eleven and much more!

Download the cheat: https://bit.ly/50-meds  View the lesson: https://bit.ly/DiazepamValiumNursingConsiderations    Generic Name Diazepam Trade Name Valium Indication Anxiety, pre-op sedation, conscious sedation, treatment of seizures, insomnia, management of alcohol withdrawal Action Decreases the effects of voltage gated sodium channels to depresses the CNS Therapeutic Class Antianxiety agents, anticonvulsants, sedative/hypnotics, skeletal muscle relax- ants (centrally acting) Pharmacologic Class Benzodiazepine Nursing Considerations • Contraindicated in hepatic dysfunction • Use caution with renal impairment • Can cause dizziness, drowsiness, lethargy, hypotension, physical depen- dence, tolerance • Instruct patient to take as directed • Caution to avoid alcohol use • Flumazenil (Romazicon) is the reversal agent

which one of you motherfuckers ate all my valium. oh yeah that was me sorry. 

Sara Jane Harris and Dr. James Michael Ryan meet at his dental practice in the Fall of 2020. By the Summer of 2021, Harris is not only working for the oral surgeon, but they are now living together. Sarah Harris' family members began to notice a change in her physical appearance. The family says Harris did not look healthy, and in the following months, Harri's growing drug addiction became evident. What's more, the family believes Ryan was giving his girlfriend drugs from his practice. First responders rush to Ryan's home after an overdose call. Inside, paramedics find Sarah Harris, unresponsive. Various vials of controlled substances, like Ketamine, Diazepam and Propofol are nearby. Now Ryan is charged in Harris' death, accused of providing the drugs that killed her. According to court documents, text messages between Ryan and Harris show Harris asking for different drugs, and Ryan instructing Her on how to take them. Joining Nancy Grace Today: Ken Belkin - Criminal Defense Attorney, BelkinLaw.com, Twitter: @Kenneth_Belkin Dr. Angela Arnold - Psychiatrist, (Atlanta GA) www.angelaarnoldmd.com, Expert in the Treatment of Pregnant/Postpartum Women, Former Assistant Professor of Psychiatry, Obstetrics and Gynecology: Emory University, Former Medical Director of The Psychiatric Ob-Gyn Clinic at Grady Memorial Hospital Dr. William Morrone - Chief Medical Examiner, Bay County Michigan, Author: "American Narcan: Naloxone & Heroin-Fentanyl Associated Mortality", RecoveryPathwaysLLC.com Robert Crispin - Private Investigator, “Crispin Special Investigations” www.CrispinInvestigations.com Lindsay Watts - Emmy-Winning Reporter, FOX 5 DC, Twitter: @LindsayAWatts, Instagram: @LindsayWatts, Podcast: "Siege on Democracy" Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

Topics on this episode include..Jake Paul FarceSPOTY 2021 Results.NFL - Rodgers Legend in the MakingHighland LeagueAnge 1st TrophyMaloney @ HibsRangers plodding along.....Arsenal top 4Bielsa on his way ?Kane v RobertsonStandard of RefsMug of truth Mikes fact hunt  Fantasy UpdateSign off joke….Quiz "Who Are You " in amongst all that as well!!

Bienvenidos a un capítulo más de su podcast favorito. Analizamos una canción del artista LEIVA y tuvimos el honor de platicar con él. Pueden ver también el episodio en YouTube See acast.com/privacy for privacy and opt-out information.

Diazepam is also known as Valium and Diastat. It comes as a tablet, solution, nasal liquid, rectal gel, and concentrated solution. There are a wide variety of uses for diazepam such as for the treatment of anxiety, pre-op sedation, procedural sedation, alcohol withdrawal, muscle spasms, and seizures. A common dosing range when treating anxiety is 2-10 mg PO bid-qid. There are also approved uses in pediatrics such as for anxiety, muscle spasms, and status epilepticus. The benefits from diazepam are often linked to the enhancement of the GABA-A, not the GABA-B, receptors. The most common side effects are drowsiness, confusion, libido changes, and irritability. There are several Black Box Warnings to be aware of such as concomitant opioid use, the risk of abuse/misuse/addiction, and the risk of dependence/withdrawal reactions. Make sure to monitor the patients' LFTs if prolonged usage as well as their blood pressure and mental status. FREE Drug Card Sheet is available for this episode at DrugCardsDaily.com along with ALL past FREE drug card sheets! Please SUBSCRIBE, FOLLOW, and RATE on Spotify, Apple Podcasts, or wherever your favorite place to listen to podcasts are. I'd really appreciate hearing from you! Leave a voice message at anchor.fm/drugcardsdaily or find me on most all socials @drugcardsdaily or send an email to contact.drugcardsdaily@gmail.com to leave feedback, request a drug, or say hello! --- Send in a voice message: https://anchor.fm/drugcardsdaily/message

This time Spicy dies on the hill that is Thief. Sit back, relax, and take some Diazepam as you take a four hour ride that no one asked for. Join us on the WTF in Vana'diel Discord for any comments you may have. https://discord.gg/mvbRyf4SAX You may also email us or leave a sincere comment, and we will (probably) gladly get back to you. Episode Drinks: Fox - Coke Classic "I went out of the box and got something different. It is delightful, actually." Spicy - N/V Willm - Blanc de Blanc Brut.

Michele MacNeill is home recovering from cosmetic surgery when she is found dead in the bathtub. Originally, her death was ruled an accident, but daughter Alexis, a medical student, wasn't convinced. Before her death, Michele MacNeill confided in her daughter that she thought her doctor husband was over-medicating her. At her husband's request, the operating surgeon prescribed four drugs, he would not normally give his patients. Two of the drugs were Diazepam and Oxycodone. Alexis took over administering her mother's meds. When Michelle seems on the mend, Alexis returns to med school. The next day, her mother is found by a younger sister dead in the bathtub. The autopsy report concluded that Michele died of cardiovascular disease but Alexis had other suspicions, compounded by a comment made by her mother... " If anything happens to me, make sure it's not your father."Joining Nancy Grace Today:Dale Carson - Criminal Defense Attorney (Jacksonville), Former FBI Agent, Former Police Officer, Author: "Arrest-Proof Yourself, DaleCarsonLaw.com Dr. Shari Schwartz - Forensic Psychologist (specializing in Capital Mitigation and Victim Advocacy), www.panthermitigation.com, Twitter: https://twitter.com/TrialDoc, Author: "Criminal Behavior" and "Where Law and Psychology Intersect: Issues in Legal Psychology" Dr. Michelle Dupre - Forensic Pathologist and former Medical Examiner, Author: “Homicide Investigation Field Guide” & "Investigating Child Abuse Field Guide", Former Police Detective Lexington County Sheriff's Department www.DMichelleDupreMD.com Justin Boardman - Former Special Victim's Unit Detective, West Valley City (Utah), Author: "I Was Wrong: An Investigator's Battle-cry for Change Withing the Special Victims Unit", JustinBoardman.com, Twitter: @boardman_trainConnor Richards - Freelance Reporter (Utah County, Utah), Twitter: @crichards1995 connorrichardsmedia.wordpress.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode 2 Returning to civilian life. Our Guest is Matt McDonell a former Airborne Infantryman  with the 173rd IBCT having served primarily in Germany and Afghanistan. Matt took advantage of educational opportunities available in the military suited to his plans for post military life.  Matt returned home enthusiastic and anxious to get on with life confident the woes that many veterans experienced in transition would not afflict him. A new home with his wife and his business starting strong verified his plans for transition were good ones. While in the military Matt was recognized to have PTSD, TBI, cognitive damage as well as pain to back, shoulders and knees experienced as a paratrooper. He also experienced headaches and nightmares.  Matt was prescribed Ambien and Diazepam, a Benzodiazepine, for these conditions.   Experiencing good results with these medications, life in transition was moving along on a healthy course. A doctor's phone call changed everything . Diazepam was now recognized as possibly more addictive than opioids when used long term. Following  the two week withdrawal regimen the doctor suggested Matt believed the issue resolved. Matt could not have prepared himself for  the punishing 18 month battle with withdrawal from Benzodiazepine that would end his marriage and cause the loss of his very successful business. Listen in as Matt shares how this  experience dramatically changed his  views on  life and the unexpected direction  now providing education and healing resources for Veterans, First Responders and Front Line Healthcare workers. DISCLAIMER: The information and content shared in each episode of the Stigma Free Vet Zone are for informational purposes only. The Stigma Free Vet Zone hosts, Mike Orban, Bob Bach and Erin Schraufnagel are not, nor claim to be, medical doctors, psychologists, or psychiatrists and should not be held responsible for any claims, medical advice, or therapy/treatment recommendations mentioned on this podcast. Any advice mentioned or shared by Mike Orban, Bob Bach, Erin Schraufnagel or their guests is strictly for purposes of bringing awareness to the veteran community and the services available. Please speak with a medical professional before taking any advice or starting any therapy or treatment discussed or shared on this podcast.

Diferencias en el viaje de cada una de estas benzodiacepinas.

Aaron Matts is the vocalist for the band ten56. and formerly of Betraying the Martyrs. Stream ten56.'s first single "Diazepam" now! --- Support this podcast: https://anchor.fm/trueshot-guest-spot/support

New Tunes from around the world from the like of  Arion, Trollfest, Wytch, Highfront, Slow Green Thing and more. Arion – Bloodline 0:00 Dorja – Dust 5:56 Trollfest – Happy 11:12 Plague of The Fallen – Bleeding and Wehement 17:20 ten56 – Diazepam 19:59 Grip on Reality – The Lament of Heracles 24:33 Osiah – […]

Episode 48: Acute Low Back Pain. Stephanie and Veronica explain common causes of acute low back pain, including lumbar strain, disc herniation, and spondylosis; spontaneous human combustion; question of the month about pneumonia. Introduction: Spontaneous Human CombustionBy Hector Arreaza, MDToday is April 19, 2021.  I’ve been trying to keep this podcast very academic and clinically relevant, with a touch of humor but very professional. I hope after this intro, you do not stop listening to us. Recently I was playing a trivia game at a friend’s house. The question was: How many spontaneous human combustion cases have been published in medical journals between 1600 and 1900? What would be your answer? I did not know the answer, but it woke up my curiosity.I did what’s expected of a normal PCP, exactly, I looked it up in Up-to-Date. The only reference to “spontaneous combustion”, I found was on the article about long-term supplemental oxygen therapy (LTOT). “Facial and upper airway burns are an infrequent complication of LTOT, but can be severe and potentially life-threatening. The main cause of burns is exposure to open flames while wearing supplemental oxygen. However, spontaneous combustion may occur with exposure to a spark source rather than an open flame. Certain factors may contribute to the risk of combustion in the absence of open flames, such as facial hair and use of hair products containing oils or alcohol.” This “spontaneous combustion” does not match the definition given the non-medical community.Spontaneous human combustion, also known as preternatural combustion, refers to a rare episode where the complete body, or significant parts of it, are reduced to ashes with no apparent source of ignition. Other items around the body of the victim are intact, making people believe that the fire originated from inside the body. This phenomenon has been described in fictional movies, documentaries, books, novels, and even medical journals. In 1984, Nickell and Fischer[3] investigated cases from the last 3 centuries. They concluded that in those cases of presumed “spontaneous human combustion” possible sources of ignition were ignored on the reports. A common characteristic among victims of spontaneous combustion was intoxication with alcohol or other substances.More recently, the American Burn Association looked into this topic and published in 2012[2] an article titled “Spontaneous Human Combustion in the Light of the 21st Century”. They state that a literature search retrieved 12 case reports between 2000 and 2012. They concluded that the so-call “spontaneous human combustion” is a reality, however, it is not exactly how people think it is. People are not just sitting around and get consumed alive in flames. The term “fat wick burns” was suggested to provide a more exact definition. The article explains that the burn victim must die for the body fat to start melting, then a break in the skin allows melted fat to impregnate clothes and produce a wick effect that allows fire to be on for a long time causing a complete carbonization of tissues. In case you are curious, the number of spontaneous human combustion cases published in medical journals between 1600 and 1900 is ninety-six (96). Citation needed.This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California. Our program is affiliated with UCLA, and it’s sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. __________________________Question of the Month: Cough and FeverWritten by Hector Arreaza, MD, read by Jacqueline Uy, MDThis is a 69-yo male patient, who has history of controlled hypertension. He comes to an urgent care clinic for acute onset of fever (102 F), cough, and shortness of breath which has progressively worsened over the last 3 days. He does NOT smoke, but uses recreational marijuana once a month, and drinks 1-2 beers a week. He goes to the doctor once a year for check-ups. He takes benazepril 10 mg daily for his hypertension. He does not believe in vaccines and his last shot was a tetanus shot 5 years ago. No surgical history. He retired as an accountant 5 years ago. Vital signs are normal except for tachycardia of 110 (his baseline is 85) and temperature of 101.5 F (38.6 C). He has bibasilar crackles on auscultation. You perform labs in clinic and he has a white count of 13.5, and a chest x-ray shows a right lower lobe consolidation. He has a negative rapid COVID-19 test. What are your top 3 differential diagnoses and what is the acute management of this patient’s condition?Let’s repeat the question: What are your top 3 differential diagnoses and what is the acute management of a 69-year-old male, non-smoker, who has fever, cough, shortness of breath, tachycardia, bibasilar crackles, elevated WBCs, a right lower lobe consolidation, and a negative rapid COVID-19 test?Send us your answer before May 7, 2021, to rbresidency@clinicasierravista.org and the best answer will win a prize!____________________________Acute Low Back Pain. By Stephanie Rubio, MS3, and Veronica Phung, MS3. Acute low back pain definition and statistics.  Eighty percent (80%) of Americans will experience back pain at some point in their lifetime.  Low back pain is the 5th most common reason for all doctor visits in the US. Most cases of low back pain are acute and 90% resolve within 1 month. Recurrence rate for back pain is high at 35% to 75%.  Acute back pain is defined as pain in the lumbar area for less than 3 months. The sources of low back pain are extensive. We would like to discuss some of the more common causes and important considerations when a patient presents with acute low back pain.  With such an extensive differential for acute low back pain, we want to briefly discuss three common causes: lumbar strain, disc herniation, and degenerative arthritis of the spine; AND three causes that require special attention: cauda equina, malignancy, and prostatitis.     Lumbar strainLumbar strain is the most common cause of acute low back pain in adults. Presentation can be acute or sub-acute after an injury or strenuous activity such as moving heavy furniture. Paraspinal muscles are typically the source of pain and can be unilateral or bilateral with or without radiation down the leg. Pain increases after immobility and specific movements depending on strain location. Patient will have a negative straight leg test.  Treatment: Patient education is key for treatment. It includes explaining that acute back pain is often benign in nature and reassurance. Advise your patients to stay active; to avoid twisting and bending, particularly when lifting; and to return to normal activities as soon as possible.  NSAIDs or muscle relaxants will help the pain process. Muscle relaxants combined with NSAIDs may have additive benefit for reducing pain. “Moderate evidence suggests that no one NSAID is superior, and switching to a different NSAID may be considered if the first is ineffective.” In clinic: Ibuprofen and Naproxen are our “go-to” medications. Acetaminophen is also an option.  “Moderate-quality evidence supports that non-benzodiazepine muscle relaxants (such as cyclobenzaprine, tizanidine, and metaxalone) are beneficial in the treatment of acute low back pain in the first seven to 14 days with effects for up to 28 days. However, muscle relaxants do not affect disability status. Make sure you warn your patient about drowsiness, dizziness, and nausea. Diazepam and Soma (carisoprodol) have the potential for abuse, so use them cautiously and for a short period only.  We also have to mention the controversial opioids. Due to the opioid epidemic, prescribe opioids only for patients with severe acute low back pain for a short period; however, there is little evidence of benefit when compared to NSAIDs.  Epidural steroid injections are not so beneficial for isolated acute low back pain, they may be helpful for radicular pain that does not respond to two to six weeks of noninvasive treatment. Transforaminal injections appear to have more favorable short- and long-term benefit than traditional interlaminar injections. Ok, we are done with lumbar strain. Disc herniationDisc herniation may also be acute or subacute with a variety of pathologies involving the displacement of disc material into the spinal cord or nerve roots. Presentation: Sudden injury could precipitate pain such as a sharp, burning, stabbing pain radiating down the posterior or lateral aspect of the leg and it is made worse when hips are flexed such as sitting. Radicular pain in the dermatome of the compressed nerve root is common. Herniation at L5-S1 is the most common location, and it would present as a loss of sensation on the dorsolateral thigh, lower leg, and dorsal foot. Patients can also have motor deficits on the lateral side of the foot which can cause a problem in tilting the sole of the foot away from the midline or difficulty toe walking. Use neurologic deficits to determine the location of herniation.Radicular pain and radiculopathy are not the same. Radicular pain is a single symptom (pain) that follows the distribution of a nerve root. Radiculopathy is a group of symptoms including, paresthesia, hypoesthesia, motor dysfunction and pain. Symptoms may be the result of compression of more than one nerve root.Nerve RootDermatomal areaMyotomal areaReflexive changesL1Inguinal regionHip flexors L2Anterior mid-thighHip flexors L3Distal anterior thighHip flexors and knee extensorsDiminished or absent patellar reflexL4Medial lower leg/footKnee extensors and ankle dorsiflexorsDiminished or absent patellar reflexL5Lateral leg/footHallux extension and ankle plantar flexorsDiminished or absent Achilles reflex S1Lateral side of footAnkle plantar flexors and evertorsDiminished or absent Achilles reflex (Source: Physio-pedia.com, https://www.physio-pedia.com/Lumbar_Radiculopathy)  Treatment: Please tell patients to keep moving as much as possible. Bed rest is not helpful and may prolong the pain process. NSAIDs should be used to decrease inflammation. Neurosurgery consultation may be needed for large herniation, especially if there is spinal canal compression, causing severe or progressive motor deficit. Use of steroids may be beneficial, but the available evidence suggests limited or no benefit. I’ve seen prednisone prescribed by neurosurgeons frequently when surgery is being delayed. If used, prednisone (60 to 80 mg daily) for five to seven days for patients who do not respond well to analgesics and activity modification. This is followed by a rapid taper to discontinuation over the following 7 to 14 days.Degenerative arthritisSpondylosis is more common in patients with advanced age. Osteophyte impingement of a nerve root can cause radicular symptoms following the nerve’s dermatome distribution as well. Presentation: Onset tends to be more insidious and posture dependent. For example, extension of the lumbar spine, like standing or walking upright causes pain. Symptoms are related to posture, patient may mention leaning on the shopping cart alleviates the pain.Neurogenic claudication is typical of spinal stenosis: pain, numbness, tingling, cramping, weakness of the lower back and extremities; which are exacerbated by walking or exertion, worse walking downhill, not worsened by biking. Neurogenic claudication is not to be confused with vascular intermittent claudication, which is pain, cramping, and tightness on the lower extremities relieved by rest, NOT relieved by walking flexed with a shopping cart. Treatment: Conservative physical therapy is an appropriate treatment. Cycling exercises can be recommended to keep your patients moving because hip flexed activities do not induce pain.  Consider a pain management clinic referral for treatment of foraminal stenosis with steroid injections. From personal experience, I can tell you, those shots really work! However, the response is not 100% effective in all patients. You do not send patients to pain management just because they are requesting chronic opioids. You send them for real treatment of pain with procedures. Cauda equina syndrome: This condition should always be considered due to the seriousness of the consequences. Symptoms may present as saddle anesthesia, loss of anal sphincter tone, and major motor weakness. Decompression should be performed within 72 hours to avoid permanent damage. Clinical suspicion is low if patient denies problems with bowel or bladder control. The most common symptom is actually neurogenic bladder, evidenced by acute urinary retention or incontinence.  Malignancy: Cancer is a serious cause of back pain. Your patient may complain of a dull, throbbing pain that progresses slowly and increases with recumbency or cough. Non-radiating pain is worse at night. More common in patients over 50 and history of cancer in the past.Genital organs: Prostatitis can cause referred low back pain. Expect to find evidence of infection in the history. So, a prostate exam and a genital exam may be needed in older males with acute or chronic low back pain.  Females may also have referred low back pain in the setting of pelvic inflammatory disease and endometriosis. So, a pelvic exam may be needed, based on your clinical judgment.     Overview of Acute Low Back Pain:   Patients with acute LBP without any red flags such as: infections, fever, or weight loss should start conservative therapy for up to 6 weeks with NSAIDS and/or muscle relaxants. Localized cold therapy for direct injury first to constrict blood vessels, reduce swelling, decrease inflammation and potentiate a numbing effect. Then heat therapy can be used after inflammation has subsided. Reevaluate in 1-3 weeks, if significant pain or neurologic complications persist or if there is no improvement in pain. If there is spinal pathology detected, then surgical evaluation is needed. Advise patients to stay active. Physical therapy may prevent recurrence. Studies showed that early physical therapy, after primary care consultation was associated with reduced risk of subsequent health care compared with delayed physical therapy. However, it is still unclear which patients with LBP should get referred to physical therapy.Depending on severity of pain and presentation of the patient, diagnostic studies such as MRI and labs can be ordered if findings are suggestive of serious pathology, such as bilateral radicular signs, urinary retention, saddle anesthesia or suspicion of a high-risk mechanism (cancer, hematoma, abscess), presence of fever, night sweats, nocturnal pain, older patients, and more.For prevention, remember proper lifting techniques should be used when moving heavy objects. Bend at the knees with a straight back and use the leg muscles to lift instead of bending at the waist to prevent injury. Maintaining a healthy weight is important for back health.Back-strengthening and stretching exercises at least 2 days a week help prevent back pain. exercise by using the proper equipment and techniques. Remember motion is lotion. Encourage patients to keep moving even as patients progress in age. Because you know you’re getting old when your back goes out more than you do.____________________________Conclusion: Now we conclude our episode number 48 “Acute Low Back Pain”. Veronica and Stephanie did a great job explaining three common causes: Lumbar strain, disc herniation, and spondylosis. Be aware of signs of cauda equine syndrome, malignancy and prostate in men and pelvic organs in women. Initial imaging and labs are not needed in most patients, but make sure to order an MRI and labs depending on the presence of red flags. Don’t forget to send us your answer to the question of the month: What are your top 3 differential diagnoses and explain the acute management of a 69-year-old male with fever, cough, tachycardia, right lower lobe consolidation, and negative COVID-19 test.Remember, even without trying, every night you go to bed being a little wiser.Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email RBresidency@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created with educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Stephanie Garcia, Veronica Phung, and Jacqueline Uy. Audio edition: Suraj Amrutia. See you next week!   References:Tiep, Brian L, MD; Rick Carter, PhD, MBA; Long-term supplemental oxygen therapy, Up-to-Date, Last updated: May 08, 2019. https://www.uptodate.com/contents/long-term-supplemental-oxygen-therapy. Accessed on March 25, 2021.  Virve Koljonen, MD, PhD, Nicolas Kluger, MD, Spontaneous Human Combustion in the Light of the 21st Century, Journal of Burn Care & Research, Volume 33, Issue 3, May-June 2012, Pages e102–e108, https://doi.org/10.1097/BCR.0b013e318239c5d7 Nickell, Joe; Fischer, John F. (March 1984). "Spontaneous Human Combustion". The Fire and Arson Investigator. 34 (3). Casazza BA. Diagnosis and treatment of acute low back pain. Am Fam Physician. 2012 Feb 15;85(4):343-50. PMID: 22335313. https://www.aafp.org/afp/2012/0215/p343.html. Lumbar Radiculopathy, Physiopedia, https://www.physio-pedia.com/Lumbar_Radiculopathy, accessed on April 9, 2021.  Fritz JM, Childs JD, Wainner RS, Flynn TW. Primary care referral of patients with low back pain to physical therapy: impact on future health care utilization and costs. Spine (Phila Pa 1976). 2012 Dec 1;37(25):2114-21. doi: 10.1097/BRS.0b013e31825d32f5. PMID: 22614792. https://pubmed.ncbi.nlm.nih.gov/22614792/  

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If you face anxiety while taking methadone, benzodiazepine medications such as Alprazolam, Diazepam, Clonazepam, Lorazepam, Chlordiazepoxide, and Oxazepam can help alleviate or reduce such symptoms.https://recoverypartnernetwork.com/drug/opioid/methadone-addiction

Diazepam, also known as Valium, is a prescription medication of the benzodiazepine family that typically produces a calming effect.https://recoverypartnernetwork.com/drug/benzodiazepine/valium-addiction

Diazepam interacts with a brain chemical called gamma-aminobutyric acid. GABA reduces brain activity in control centers for emotions, memory, rational thinking, and involuntary body functions such as breathing. Valium further stimulates these effects of GABA, resulting in muscle relaxation, decreased anxiety, and drowsiness.https://recoverypartnernetwork.com/drug/benzodiazepine/valium-addiction

The average time for Valium concentrations to peak in the blood is 1-1.5 hours. The absorption can be significantly delayed or dropped if diazepam is taken around the time of a fairly heavy meal. When food is consumed close to the dose, it can delay the absorption of diazepam for about 45 minutes compared to the 15 minutes it would take when no food is present. The initial distribution phase of Diazepam has a half-life of approximately 1 hour, although it may last for more than 3 hours. After that initial phase, there is a lengthy elimination phase for the half-life of up to 48 hours.https://recoverypartnernetwork.com/drug/benzodiazepine/valium-addiction

Lo que se debe saber sobre el diazepam en los perros Cuando se tienen mascotas en casa, es necesario saber de todo un poco, especialmente cuando de cuidados de salud se trata. A veces, los perros presentan alguna complicación que no puede esperar hasta llevarlo al veterinario, por lo que los papás y las mamás tienen que tener conocimientos básicos en el suministro de medicamentos. Lee el artículo en nuestro blog: https://www.daonly.com/blogs/noticias/h1-em-lo-que-se-debe-saber-sobre-el-diazepam-en-los-perros-h1-p-p Síguenos en nuestras redes sociales: Facebook: https://www.facebook.com/daonlypets/ Instagram: https://www.instagram.com/daonly_pets/ Twitter: https://twitter.com/daonly_mascotas Youtube: https://www.youtube.com/channel/UCb8ukpllNwUhUBv7V3rpn_w?view_as=subscriber www.daonly.com

Importante figura na luta pelos direitos das populações mais vulneráveis, ele fala sobre as ameaças que recebeu e a violência na Cracolândia Embora seja do grupo de risco da Covid-19, Padre Júlio Lancellotti, prestes a completar 72 anos, tem enfrentado a pandemia na linha de frente. Atuando diariamente no socorro da população mais vulnerável, ele leva alimentos, roupas, itens de higiene e luta por acomodação para as pessoas em situação de rua. Pároco na Igreja de São Miguel Arcanjo, na Mooca, e à frente da Pastoral da Rua em São Paulo, ele é também um dos fundadores da Casa Vida, que acolhe crianças soropositivas, e já atuou dentro de penitenciárias e da antiga Febem (hoje Fundação Casa). "O sistema neoliberal tem uma lógica, e a lógica é do descarte", diz o padre, teólogo e pedagogo que luta pelos direitos e por dignidade para esses excluídos, ou "descartados", como prefere chamar. Essa batalha chegou a transformá-lo em alvo de difamações e ataques nas redes sociais e nas ruas, e em setembro ele registrou um boletim de ocorrência após ser ameaçado. Mas a violência não o intimida. Padre Júlio já resistiu em reintegrações de posse, levou bomba de gás em manifestações de rua e denuncia com frequência a violência policial. "Esse medo das ameaças não pode me acovardar. Eu seria falso se assumisse o silêncio ou me calasse diante da homofobia, da transfobia, do racismo, do ódio aos pobres, de tortura a presos e a moradores de rua."  [IMAGE=https://revistatrip.uol.com.br/upload/2020/12/5fd3af559e105/padre-julio-lancelloti-trip-fm-mh2.jpg; CREDITS=Mario Ladeira; LEGEND=Embora seja do grupo de risco da COVID-19, Padre Júlio Lancellotti, prestes a completar 72 anos, tem enfrentado a pandemia na linha de frente] Com 35 anos de experiência lidando com a carência e com as desigualdades, ele compartilha a Trip sua visão sobre os caminhos para amparar a população de rua, os egressos do sistema carcerário e a Cracolândia. "Vemos a Cracolândia não pela dependência química, mas pela questão da classe social da qual eles são. Se tivessem um lugar para morar, não seria problema. O problema é que eles estão expostos e são visíveis."  Trip. Padre, o senhor desenvolve um trabalho há mais de 30 anos com a população de rua da cidade de São Paulo. Queria que você, que conhece de perto, falasse de onde vêm e quem são as pessoas em situação de rua em São Paulo. Padre Júlio Lancelotti. A população de rua é muito heterogênea, não dá para dizer que tem um perfil só. Agora durante a pandemia, e desde do golpe que derrubou a ex-presidente Dilma, a crise fez aumentar muito o número de pessoas na rua. Nenhuma causa é única, não é dizer "é só o desemprego" porque no Brasil tem 13 milhões de desempregados e não estão todos na rua. É um arranjo, uma questão pessoal de perdas sucessivas que não são trabalhadas de maneira que sustentem essa pessoa. Tem muitos jovens na rua, muitos idosos. Aumenta o número de mulheres com crianças. Gosto muito da expressão que o Papa Francisco usa, desde a Exortação Apostólica Evangelii Gaudium, dos "descartados". O sistema neoliberal tem uma lógica, e é a lógica do descarte. Quando você fala "excluído", você vai descobrir que existem políticas de inclusão, mas, quando se fala "descartado", não existe política de "encarte". O que se faz com o copo descartável? O que se faz com um prato descartável? É lixo. Então essas pessoas são completamente insignificantes, indesejáveis e de certa forma o sistema não as quer. Elas fazem parte de uma lógica perversa que as joga no lixo. A política pública é o que sobra para os descartados. Acho que seria muito escandaloso eles morrerem todos de uma vez, então tem política pública para mantê-los com um resto de vida. Nos últimos anos houve uma evolução nos movimentos feministas, antirracistas, das questões de gênero e LGBTQ+. Mas tem um universo que parece esquecido, que é o dos egressos do sistema carcerário. Essa população é gigantesca, só cresce, e, quando um sujeito sai da cadeia, ele sai sem nada. Como é para esse cidadão que paga sua pena voltar para a rua sem saber o que fazer e para onde ir? Eu convivi muito com os presos e as presas. Guardo muito na minha memória a convivência com as mulheres presas. Fiquei muitos anos acompanhando, desde que elas começaram a entrar naquela penitenciária feminina do Tatuapé, até quando a penitenciária foi extinta. Sempre no dia de Natal eu estava com elas, na Páscoa, na Semana Santa, o ano inteiro eu celebrava a missa com essas mulheres presas. Esse dado que você levanta é um dado muito importante, porque nenhum desses grupos se preocupa com as mulheres presas, com as mulheres trans presas, com os gays presos, com o grupo LGBT que está preso, com os negros, que são a maioria dos presos. Essas bandeiras desfraldam dos espaços de liberdade. O movimento que tem dentro dos presídios são os chamados de PCC, dos comandos, que dominam o sistema carcerário. Tanto que você vê o pouco que o Estado ou os governos mexem no sistema carcerário, porque é complicado e porque vai desnudar uma face bárbara da corrupção e do crime organizado. Agora, um dos últimos Censo apontou – e até é um dado delicado de dizer porque pode aumentar o preconceito – que 42% da população de rua passou pelo sistema carcerário. E eles trazem para a rua esse mundo. Às vezes eu vejo alguns desses irmãos com quem eu convivo e que estão em situação de rua, e a impressão que eu tenho é que eles ainda estão dentro da prisão, só que o pátio agora ficou maior. Todos eles têm experiência de tortura, de violência, de maus tratos, do exercício do poder. Essa estrutura da rua é muito marcada pela estrutura carcerária, e, por incrível que pareça, os espaços de acolhida e de convivência para a população de rua lembram muito essa estrutura para eles. [QUOTE=1154] Porque eles não têm autonomia, têm horário para entrar, para sair, para comer, para dormir, horário da televisão. Alguns dizem que certos centros de acolhida parecem "semiliberdade''. E uma das questões sérias com a população de rua é que ela é tutelada: sempre as chamadas políticas públicas são de tutela, elas não são geradoras de autonomia. Mesmo porque a autonomia, no mundo em que a gente vive, é muito perigosa. Autonomia de pensamento, autonomia de sentimento, autonomia de movimento. Então a população em situação de rua é uma população extremamente tutelada, e essa tutela infantiliza, embrutece e desumaniza. [IMAGE=https://revistatrip.uol.com.br/upload/2020/12/5fd3afa79968e/padre-julio-lancelloti-trip-fm-mh1.jpg; CREDITS=Mario Ladeira; LEGEND=Pároco na Igreja de São Miguel Arcanjo, na Mooca, e à frente da Pastoral da Rua em São Paulo ele é também um dos fundadores da Casa Vida, que acolhe crianças soropositivas, e já atuou dentro de penitenciárias e da antiga Febem (hoje Fundação Casa).] LEIA TAMBÉM: O amor-próprio entre mulheres na Cracolândia A dependência química, em especial do crack, é um problema muito marcante e que atinge muitas pessoas nas ruas. Para você, qual seria o caminho para resolver essa questão, para além do trabalho que você já faz de acolhimento e escuta dessas pessoas? Eu acho que nós não sabemos lidar com o dependente químico em geral, porque não existem dependentes químicos só na rua. Seguramente no condomínio de todos que estão nos lendo tem dependentes químicos, e tem os dependentes de drogas lícitas e de drogas ilícitas. A questão não é a dependência química, é a questão social dessa pessoa. Quem tem uma dependência química e mora numa cobertura não tem problema nenhum. Ele pode ter problemas com os condôminos, com o síndico, alguma coisa assim. Mas você acha que em São Paulo só se usa crack na Cracolândia? Será que são só eles? Quem é que usa cocaína em São Paulo, são só os moradores de rua? Quem usa heroína? E quem usa Diazepam e todos esses remédios que muita gente usa para poder dormir? Isso sem falar do consumo de álcool. Eu digo: tem a Cracolândia, mas tem a Pingolândia, e a Cervejolândia, a Whiskilândia. Só que a única que todo mundo vê é a Cracolândia. Ali se vê, não pela questão da dependência química, mas pela questão da classe social a qual eles pertencem. Se eles não fossem pobres e miseráveis, se tivessem um lugar para morar, não seria problema. O problema é que eles estão expostos e são visíveis. De certa forma todos nós temos alguma dependência química. LEIA TAMBÉM: O rapper Dexter divide o que aprendeu com seu público e com outros ex-presidiários Você defendeu muito a estratégia de se utilizar hotéis que ficaram ociosos durante a pandemia para alojar a população de rua neste momento, uma medida que foi tomada em algumas cidades na Europa. Com a sua experiência, depois do afeto, de acolher e ouvir essas pessoas, por onde começar a resolução desse problema da população em situação de rua? Seria por providenciar uma habitação decente para essas pessoas? Eu acredito que sim. Mas veja, nós precisamos ter claro que nós temos que superar a desigualdade. Começa por uma superação da desigualdade, da opressão, da tirania, da corrupção, do crime organizado. São várias as questões que se interrelacionam para que a vida seja humanizada. [QUOTE=1155] Porque a reversão histórica não é feita num episódio. Nós chegamos onde chegamos porque nós fomos acumulando uma forma de ser, uma forma de agir, uma forma de descartar, e aí é uma coisa que me chama muito a atenção: a pessoa que é tratada com desumanidade continuamente e repetidamente, ela vai acabar se desumanizando também. Isso também entra nela. Por exemplo, a imprensa me cobrou muito sobre o arrastão que aconteceu lá na Cracolândia na terça-feira, dia 8 de dezembro. Só que toda a mídia mostrou o último capítulo da novela, sem mostrar como é que aquilo começou e por que chegou naquilo. A gente convive com essas pessoas, e é muito doloroso ver isso. Eu disse, e foi difícil as pessoas compreenderem, que a violência gera violência. Isso a minha tataravó já dizia. As pessoas que são tratadas com violência, o repertório delas é responder com violência. Se eu te maltratar, você está programado mentalmente para me responder agressivamente. Se você me maltratar, eu estou programado emocionalmente pra te responder duro também. Dificilmente uma pessoa que é maltratada responde para o agressor de uma maneira suave: "Calma, não é bem assim", "veja bem". Então se um morador de rua me trata mal, eu imediatamente o trato mal também. Agora, quando eu o trato mal e ele me trata mal de volta, eu o criminalizo. Mas ele está me respondendo no diapasão, na pauta que eu dei para ele. O povo que está na rua sofre diariamente humilhação, escracho, falta de acesso à água potável, à alimentação, à um lugar adequado para urinar, não tem um lugar para defecar, a roupa pode estar fedendo, ele não tem outra roupa pra trocar. Ele mesmo em alguns momentos se sente desagradável, a boca não sente mais o sabor, não consegue dormir, é uma perturbação contínua. Como é que essa pessoa vai responder positivamente? Eu falo muito isso: eles não são nem anjos nem demônios, são pessoas. Imagina você ou eu vivermos uma semana nessas condições? Uma semana esperando alguém te trazer comida, sem saber se vão trazer ou não? Uma semana comendo só aquilo que te dão, sem poder escolher? Tendo que dormir na calçada? Eu acredito que, com tanta repressão, eles reagem pouco. [IMAGE=https://revistatrip.uol.com.br/upload/2020/12/5fd3afdda6321/padre-julio-lancelloti-trip-fm-mh4.jpg; CREDITS=Mariana Pekin; LEGEND=Mediados por Milly Lacombe, Sebastião Oliveira, da Associaçao Miratus de Badminton, o padre e militante dos direitos humanos Júlio Lancellotti, e a cientista política Ilona Szabó conversaram sobre segurança pública] Eu entrevistei aqui o Celso Athayde, uma liderança importante das periferias, criador da CUFA, e ele disse: "Por alguma razão o povo pobre ainda recebe passivamente a situação que lhe é imposta. Imagine se esse povo começa a se organizar para atacar e para retribuir". Por que você acha que isso não acontece? Porque o povo pobre também é ideologizado pela ideologia dominante. Eles assistem aos meios de comunicação dominantes, eles recebem a estrutura dominante. Eu gosto muito de um pensamento da Simone de Beauvoir que diz: "Os opressores não teriam tanto poder se não tivessem tantos cúmplices entre os oprimidos". É aquilo que o nosso Paulo Freire, tão maltratado no Brasil dessa atual política, diz: "A cabeça do oprimido é o quarto de hóspedes do opressor". Então a nossa sociedade funciona ideologicamente para que o negro pense com a cabeça do branco, a mulher pense com a cabeça do homem, a criança com a cabeça do adulto, o índio com a cabeça do chamado civilizado. E o pobre, muitas vezes, ele pensa com a cabeça do rico. Por isso que a educação no Brasil não é libertadora, ela é uma educação bancária, como dizia o Paulo Freire, onde se coloca na cabeça das pessoas a ideologia dominante. Você vê, os pobres votam no Bolsonaro. Aqui em São Paulo, votam em quem? O que viram no Boulos? "Esse é um cara perigoso. Ele vai invadir meu domicílio". Isso o povo todo pensa. Se você perguntar a um motorista de táxi, ou perguntar na feira, para o povão que está lá: "A cor do menino qual é?". Todos vão dizer: "É azul". E a cor da menina? Cor-de-rosa. O que é o vermelho? Comunista. O que é o comunista? Perigoso. A nossa maneira de pensar hoje é muito empobrecida. Nós nunca vivemos um momento de tanto empobrecimento do pensamento como nós estamos vivendo agora. Quando foi homenageado pelo Trip Transformadores em 2018, você disse que se sente sempre um fracassado, e quando não for um fracassado, é porque aderiu ao sistema. E disse ainda: "Eu não vou ver a mudança pela qual eu luto, porque essa luta é uma luta histórica". Depois de 35 anos batalhando no dia a dia, você fala numa reversão histórica. Você acha que nós estamos piorando como sociedade? Andamos para trás de uma maneira geral? Eu acredito que nada é monolítico, nós temos luz e trevas. Talvez estejamos vivendo um momento em que as trevas, ou o que nós chamamos de trevas, porque eles também nos acham trevas, esteja muito forte. A gente também seria muito pretensioso de achar "eu sou a luz". Mas nós temos que ter instrumentos de análise. Uma objetividade é a qualidade de vida: o nosso povo se alimenta adequadamente? Se alimenta o necessário? O nosso povo tem um lugar decente para dormir? O trabalho que o nosso povo faz é remunerado adequadamente? As desigualdades entre o nosso povo são em que nível, de um para trinta, de um para três mil, ou de um para trezentos mil? Existem dados objetivos, a própria ONU tem os indicadores de desenvolvimento humano. Por exemplo, se temos acesso à água potável, ao esgoto, à alimentação, à informação verdadeira e não manipulada, acesso a processos civilizatórios e de humanização. O que nós temos neste momento no Brasil é uma perda desses indicadores. Estamos com 13 milhões de desempregados. Aumentamos o número de pessoas abaixo da linha da miséria, que são menos de 2 dólares por dia. Esses parâmetros mostram, objetivamente, que nós estamos num processo de desumanização acelerada. O presidente colocou em xeque todos os programas de saúde mental, suspendeu até janeiro todos os exames de HIV e de hepatite C. O número de feminicídio dispara no Brasil. Tem muito mais gente na rua, muito mais gente desempregada, muita gente dormindo na calçada e temos excesso de bens para alguns. Esses dados são os indicadores de desumanização que nós temos. Você viu que na Argentina começou a taxação das grandes fortunas? Agora, a ideologia dominante fez a cabeça do nosso povo e o desempregado é contra a taxação de grandes fortuna. [IMAGE=https://revistatrip.uol.com.br/upload/2020/12/5fd3b008e79c8/padre-julio-lancelloti-trip-fm-mh5.jpg; CREDITS=Mario Ladeira; LEGEND=Padre Júlio já resistiu em reintegrações de posse, levou bomba de gás em manifestações de rua e denuncia com frequência a violência policial, e manteve seu trabalho humanitário cotidiano. ] LEIA TAMBÉM: Os objetos mais preciosos dos moradores de rua Qual foi a última vez que você chorou? Hoje me emocionou muito uma notícia que eu vi: o Canadá comprou em vacinas a quantia de cinco doses para cada cidadão canadense, quando são necessárias duas doses. Para quê? Os países ricos vão comprar toda a vacina, e o que vai sobrar para a Etiópia, o que vai sobrar para a Somália? Esse é o mundo que nós não podemos aceitar. Seria bonito que o Canadá usasse as duas doses da vacina em cada canadenses e em todos os imigrantes que moram lá, e as outras três que sobrarem fossem doadas aos países pobres. Porque nesse momento a vacina virou um negócio político. A discussão no Brasil sobre a vacina é política, é ideológica. Estamos vivendo uma emergência sanitária que precisa de respostas solidárias, humanizadoras. Muita gente falou: "Nós vamos sair dessa pandemia melhores". Você olha a 25 de março nesses dias e você diz: "Como é que ainda não entrou na cabeça desse povo?". Daqui 15 dias é Natal, todos os que se contaminaram lá vão aparecer no Natal. Então a gente não pode ser nem alarmista, nem pessimista, mas a gente tem que ser realista. Talvez quando eu diga seja um pouco incompreensível, mas eu luto não pra ganhar, mas para ser fiel. Durante a sua luta você tem recebido ameaças, algumas concretas. Você chegou a fazer boletim de ocorrência após dois homens gritarem ameaças para você na rua. Mas dá a impressão às vezes que você não tem medo de morrer. Você tem medo de morrer ou não? Acho que medo de morrer todos temos, porque é um desconhecido. Eu tenho que aprender o que é morrer. Outro dia uma jornalista me perguntou se eu tenho alguma pretensão política e eu falei que eu tenho três pretensões: o hospital, o asilo ou o cemitério. Na idade em que eu estou são essas as três possibilidades no meu horizonte. Eu não sei como é morrer, eu ainda não morri. Eu vou aprender a morrer na hora que eu morrer, como você. É uma aprendizagem tão nossa que a gente não vai poder contar para os outros como é que foi. Esse medo eu acho que todos nós temos. Agora, o medo das ameaças não pode me acovardar. Eu não tenho condições, até de identidade e psicológicas, de voltar atrás naquilo que eu acredito e naquilo que eu faço. Eu não posso ver maltratarem os moradores de rua e ficar calado, não estaria em mim. Eu seria falso se eu assumisse o silêncio ou me calasse diante de uma homofobia, diante de transfobia, diante de racismo, diante de ódio aos pobres, de tortura a presos e a moradores de rua. Eu formei a minha identidade e eu me reconheço assim. Vou fazer nesse mês 72 anos. Nesses anos todos de vida quatro pessoas que iam me matar vieram pedir perdão e dizer que iam me matar e não conseguiram. Eu confio na proteção de Deus. Confio na força e na coragem, porque se eu for ficar com medo... Eu gosto de um canto das comunidades de base que diz "quem tem medo sofre mais". A gente tem medo. Eu tenho medo. Eu choro. E eu ainda não sei como é morrer, embora a minha vida seja marcada pela morte de muitas pessoas queridas. Eu tenho marcado em mim a morte do meu pai, a morte muito dolorosa da minha mãe, dos meus dois irmãos, da minha cunhada, de todas as crianças que eu cuidei na Casa Vida e que morreram de Aids. Todas muito pequeninas, jovens, a mais velha morreu com 16 anos. Os outros todos com menos idade. Eu carrego a marca das dores de todas essas pessoas queridas. Me marcou muito a morte de Dom Luciano Mendes de Almeida, a morte de Dom Paulo Evaristo Arns, a morte de Dom Pedro Casaldáliga. Todas as pessoas que me marcaram na vida. Eu tenho muitos nomes. O que nos humaniza é termos muitos nomes gravados na nossa memória. LEIA TAMBÉM: Black Alien conta como superou as drogas e a morte do melhor amigo Sobre o Natal, parece que é uma data que se transformou numa campanha gigantesca de publicidade, shoppings, presentes e Papai Noel com as renas. Se a gente já tinha perdido conexão com o seu significado, agora ele ainda vai acontecer em meio a uma pandemia que impossibilita os encontros nas famílias. O que é o Natal para você? O Natal é pra mim é forte e importante na simplicidade de um Deus que se faz humano, fraco e pequeno. De um Deus que não é poderoso e é amoroso, que não é adulto e é criança, que não é rico mas é pobre, que não está no palácio mas está na rua. É de novo chamar a nossa atenção de crer no impossível, e de crer no inacreditável, e esperar aquilo que vai chegar, não sabemos quando, mas que é o despojamento do amor. Para mim o Natal é essa simplicidade amorosa de dar a vida, de estar com os fracos e nunca querer ser forte. [IMAGE=https://revistatrip.uol.com.br/upload/2020/12/5fd3b061ac2b0/padre-julio-lancelloti-trip-fm-mh6.jpg; CREDITS=Mario Ladeira; LEGEND=Padre Júlio Lancelloti]

Benzo Brain. Fuzzy Brain. Cog Fog. Memory loss and cognitive dysfunction are common in benzo withdrawal and these symptoms can linger for a long time. Why does this happen? What do the studies say? And what steps can one take to improve things? In today's episode, we dive into the confusing world of cognitive dysfunction. We also hear a story from Connecticut, share a comment about isolation, answer a question about single-use benzos for medical treatment, and chat a bit about caregivers. I hope you enjoy it. https://www.easinganxiety.com/post/benzo-brain-cognitive-symptoms-in-withdrawal-bfp073Video ID: BFP073 Chapters 00:00 Theme00:57 INTRODUCTION07:25 MAILBAG: Intro08:10 Comment: Isolation10:17 Question: Single Use Benzos15:15 BENZO STORY: Ed from Connecticut26:03 FEATURE: Benzo Brain49:38 MOMENT OF PEACE  Resources The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Easing Anxiety of the resource or any recommendations or advice provided therein. MAILBAGAshton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.FEATURE: Benzo BrainAshton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.Foster, D E. Benzo Free: The World of Anti-Anxiety Drugs and the Reality of Withdrawal. Erie, Colorado: Denim Mountain Press, 2018. https://easinganxiety.com/book. Frances, Allen. “Yes, Benzos Are Bad for You.” Pro Talk: A Rehabs.com Community, June 10, 2016. Accessed October 13, 2016. https://www.rehabs.com/pro-talk-articles/yes-benzos-are-bad-for-you/.Gorenstein, C., M. A. Bernik and S. Pompéia. “Differential Acute Psychomotor and Cognitive Effects of Diazepam on Long-Term Benzodiazepine Users.” International Clinical Psychopharmacology 9(3)(1994):145-53. Accessed March 6, 2017. doi:10.1097/00004850-199409000-00002.Tata, P.R., J. Rollings, M. Collins, A. Pickering and R. R. Jacobson. “Lack of Cognitive Recovery Following Withdrawal from Long-Term Benzodiazepine Use.” Psychological Medicine 24(1)(February 1994):203-13. Accessed April 15, 2018. doi:10.1017/S0033291700026969.  The PodcastThe Benzo Free Podcast provides information, support, and community to those who struggle with the long-term effects of anxiety medications such as benzodiazepines (Xanax, Ativan, Klonopin, Valium) and Z-drugs (Ambien, Lunesta, Sonata). WEBSITE: https://www.easinganxiety.comMAILING LIST: https://www.easinganxiety.com/subscribe YOUTUBE: https://www.youtube.com/@easinganx DISCLAIMERAll content provided by Easing Anxiety is for general informational purposes only and should never be considered medical advice. Any health-related information provided is not a substitute for medical advice and should not be used to diagnose or treat health problems, or to prescribe any medical devices or other remedies. Never disregard medical advice or delay in seeking it. Please visit our website for our complete disclaimer at https://www.easinganxiety.com/disclaimer. CREDITSVideo footage used in Moment of Peace was provided / licensed by…— Storyblocks (https://www.storyblocks.com) Music provided / licensed by Storyblocks Audio — https://www.storyblocks.com Benzo Free Theme — Title: “Walk in the Park” — Artist: Neil Cross Meditation Music— Title: “Always Mine”— Artist: Keith Anthony Holden PRODUCTIONEasing Anxiety is produced by…Denim Mountain Presshttps://www.denimmountainpress.com ©2022 Denim Mountain Press – All Rights Reserved

Share this post with others: Benzo Brain. Fuzzy Brain. Cog Fog. Memory loss and cognitive dysfunction are common in benzo withdrawal and can linger for months. Why does this happen? What do the studies say? And what steps can one take to improve things? In today's episode, we dive into the confusing world of cognitive dysfunction. We also hear a story from Connecticut, share a comment about isolation, answer a question about single-use benzos for medical treatment, and chat a bit about caregivers. I hope you enjoy it. Welcome to Episode #73 In today's episode of the podcast, we focus our attention on memory loss and cognitive dysfunction. These are common symptoms in benzo withdrawal and can be one of the longest lasting. We look at some studies about these cognitive effects and even list four positive things to remember. We also have a story from Connecticut, a question about single-dose benzos, a comment about isolation, and a few other interesting things. I hope you enjoy it. Chapters 00:00  Theme00:57  INTRODUCTION07:25  MAILBAG: Intro08:10  Comment: Isolation10:17  Question: Single Use Benzos15:15  BENZO STORY: Ed from Connecticut26:03  FEATURE: Benzo Brain49:38  MOMENT OF PEACE Episode Resources The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Benzo Free of the resource or any recommendations or advice provided therein. MAILBAGAshton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.FEATURE: Benzo BrainAshton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.Foster, D E. Benzo Free: The World of Anti-Anxiety Drugs and the Reality of Withdrawal. Erie, Colorado: Denim Mountain Press, 2018. http://www.benzofree.org/book.Frances, Allen. "Yes, Benzos Are Bad for You." Pro Talk: A Rehabs.com Community, June 10, 2016. Accessed October 13, 2016. https://www.rehabs.com/pro-talk-articles/yes-benzos-are-bad-for-you/.Gorenstein, C., M. A. Bernik and S. Pompéia. "Differential Acute Psychomotor and Cognitive Effects of Diazepam on Long-Term Benzodiazepine Users." International Clinical Psychopharmacology 9(3)(1994):145-53. Accessed March 6, 2017. doi:10.1097/00004850-199409000-00002.Tata, P.R., J. Rollings, M. Collins, A. Pickering and R. R. Jacobson. "Lack of Cognitive Recovery Following Withdrawal from Long-Term Benzodiazepine Use." Psychological Medicine 24(1)(February 1994):203-13. Accessed April 15, 2018. doi:10.1017/S0033291700026969. Site Links VISIT US ONLINE— WEBSITE: https://www.easinganxiety.com— YOUTUBE: https://www.youtube.com/easinganxiety— INSTAGRAM: https://www.instagram.com/easinganxiety PLEASE LET US KNOW WHAT YOU THINK— COMMENT: On this video in YouTube— COMMENT: On the blog post on our website— EMAIL: feedback@easinganxiety.com SUPPORT US— Make a Donation: https://www.easinganxiety.com/donate Podcast Summary This podcast is dedicated to those who struggle with side effects, dependence, and withdrawal from benzos, a group of drugs from the benzodiazepine and nonbenzodiazepine classes, better known as anti-anxiety drugs, sleeping pills, sedatives, and minor tranquilizers. Their common brand names include Ambien, Ativan, Klonopin, Lunesta, Valium, and Xanax. Introduction Today I spoke briefly about caregivers and some upcoming live events for the channel. Mailbag In today's mailbag, we shared a comment from Anne about isolation and explored a question from Robert about single-use benzos for medical procedures. Benzo Story Today's story is from Ed in Connecticut. Feature Today's feature is focused on memory loss and cognitive dysfunction in benzo withdrawal. We take a look at the Ashton Manual, share a few Swedish studies on the topic,

Welcome, this week the brothers take a look at the new Invisible Man staring Elisabeth Moss. Come listen, as we talk about, Diazepam, homewrecking, eyeball suits, and how we totally didn't record this episode before, only to have it deleted and have to rerecord it again for you fine people.... Thank you for listening, please follow us on our other platforms, Twitter @DISYPod and Instagram @didiscareyoupod If you wanna shoot us an email you can do so at DISYPod@gmail.com

Xanax, Valium, Librium, Rohypnol, Ativan, Klonopin, Phenobarbital--if you want to know how benzos and barbiturates work in the brain, check out this episode. I also talk about the history of anxiolytics (anti-anxiety drugs), the connection to race and class in the war on drugs, and the consequences of irresponsible use. Harm Reduction saves lives. Share the knowledge. 

En este episodio tan especial de FILLER QUEEN estamos on location con la leyenda de la peluquería e íntima amiga Azu, que nos cuenta su odisea abriéndose paso en el mundo de los tés del supermercado. Desgranamos además la última actuación viral de Nathy Peluso y discutimos la sobremedicación en la sociedad entre otro montón de cosas.

DJ kicks of the month of October by revisiting The Invisible Man in 4K.  Does this Atmos mix live up to the hype?  How is the 4K and HDR?  Do either the sound or the picture quality enhance or detract from the overall Home Theater Experience?  Before we answer all that we have listener comments, this weeks movie recommendations and this weeks Featured Home Theater from Nelson Albino.  So much this week, you better just Push Play.

DJ kicks of the month of October by revisiting The Invisible Man in 4K.  Does this Atmos mix live up to the hype?  How is the 4K and HDR?  Do either the sound or the picture quality enhance or detract from the overall Home Theater Experience?  Before we answer all that we have listener comments, this weeks movie recommendations and this weeks Featured Home Theater from Nelson Albino.  So much this week, you better just Push Play.

Wenn deine Neurotransmitter wie Adrenalin, Noradrenalin, Serotonin und Dopamin aus dem Gleichgewicht kommt, kann es zu verschiedenen psychischen Erkrankungen kommen. Ob Depression, Angststörungen, Schlafstörungen, Psychosen, Schizophrenie oder ADHS - Psychopharmaka werden vielfältig eingesetzt und helfen die Lebensqualität der Betroffenen zu verbessern. Die verschiedenen Arten und Wirkstoffe wie Diazepam, Valproinsäure, Lithium, Amphetamine, Benzodiazepine, andere Antidepressiva, Hypnotika, Psychostimulantien, etc. sowie deren Wirkungen, Nebenwirkungen und auch das Abhängigkeitspotenzial erkläre ich dir in dieser Folge. Was einige Netflix-Serien und -Filme damit zu tun haben und warum es keine gute Idee ist, deine Depression mit Kokain, Crystal Meth, Speed oder psychedelischen Pilzen zu bekämpfen, erkläre ich dir ebenfalls. Und ich habe Tipps für dich, was du zusätzlich (natürlich immer nur in Rücksprache mit deinem Arzt oder Apotheker) tun kannst, um deine psychischen Beschwerden zu mildern. Omega-3, Vitamin D3 und Phytopharmaka wie Johanniskraut spielen dabei eine wichtige Rolle. Wenn du Fragen oder Themenwünsche hast, melde dich gerne direkt bei mir, entweder per Mail an info@jan-reuter.com oder unter https://www.instagram.com/apotheker_janreuter/ auf Instagram. Weitere interessante Videos zu verschiedenen Themen findest du auf meinem YouTube-Kanal: https://www.youtube.com/channel/UCg_3QwhdZvS96qMg4Q_H3-w Ich wünsche dir viel Spaß bei der Folge, Dein Jan Zu Risiken und Nebenwirkungen fragen Sie Ihren Arzt oder Apotheker.

The Guru is back vlogging again, like Porky Russ on Diazepam.

Leigh Whannell's The Invisible Man re-imagines the Universal Monsters character as a stalker. The theme reminded us of one of Seventh Row's favourite films, Steven Soderbergh's Unsane (2018), so we had to discuss them in conversation with each other. Michael Snydel from The Film Stage Show joins the entire Seventh Row editorial team: Editor-in-Chief Alex Heeney, Executive Editor Orla Smith, Associate Editor Brett Pardy, and Editor-at-Large Mary Angela Rowe for this episode. We discuss internal versus external horror, genre conventions, Chekhov's Diazepam, and much more. For detailed show notes, visit: https://seventh-row.com/2020/03/31/ep-35:-the-invisible-man-and-unsane/ Follow Seventh Row on Twitter, Instagram, and Facebook, and read our articles at seventh-row.com.

Diazepam has numerous dosage forms. There are rectal, injectable, and oral formulations of the drug that are commonly used in clinical practice. Diazepam has 2 major metabolic pathways. It is broken down primarily by CYP3A4 and CYP2C19, leaving open the potential for numerous drug interactions. I discuss this further in the podcast. Diazepam is on the Beers list because it has a tendency to accumulate in the geriatric patient population and cause adverse effects like sedation, confusion, and falls. Respiratory depression, coma, and death are significantly more likely in overdose situations where opioids are used in combination with benzodiazepines like diazepam.

Alprazolam, Bromazepam, Clorapezam, Lorazepam, Midazolam, Diazepam... afinal de contas, qual o melhor benzodiazepínico para sedação consciente do consultório odontológico? Nesse podcast vou te falar dos TOP 3 benzodiazepínicos e qual a indicação de cada um.

I denne episode af FOAMmedicPHARMA serien taler vi om Midazolam. Vi har set på ambulancetjenestens nye antiepileptikum og hypnotikum. Mange regioner har indført Midazolam i stedet for Diazepam og derfor er det oplagt at se nærmere på det medikament. Vi forsøger os igen med en mere evidensbaseret tilgang til løsningen på vores case i et forsøg på at stimulere til kritisk tænkning når løsningen ikke er inden for de kendte instrukser. Abonner eller hent via iTunes, Podbean, TUNE IN, Spotify, StitcherRadio, Soundcloud eller hvor du henter dine podcast. Støt FOAMmedics arbejde med 5 eller 10 kr pr. podcast. Hvis du har lyst til at støtte vores arbejde med at lave lækker lyd og skrift så klik ind på 10er.dk og støt os med 5,10 eller 15 pr. podcast episode, så bliver vi så sindsygt stolte og glade. Eller klik på 10'er logo her under og en pop-up løsning kommer frem. DISCLAIMER Det her er vores fortolkning af det pågældende medikament, det er ikke den endegyldige sandhed og vi opfordre som altid til at være kritisk over for den viden man hører og selv tjekke op på relevant viden og fakta. Du vil muligvis høre information eller om tilstande vedr. et medikament, hvor du ikke har delegation til at benytte medikamentet, men som udelukkende bliver omtalt, for at vi kan blive klogere i processen.Denne podcast er ikke en erstatning for pro.medicin.dk eller vores lokale retningslinjer. Links og henvisninger Introen til dette afsnit er lavet af Tyler Christifulli fra FOAMfrat, tjek dem ud, de har masser af fedt materiale. Pro.medicin om benzodiazepiner (hypnotika) Pro.medicin om Sederende midler (Odontologisk medicinvejledning) Pro.moedicin om Midazlom Youtube videoer som beskriver: GABA , Benzodiazepiner, Fremmende og hæmmende nervesignaler Bøger: Paramedic Textbook - Mosby af Mick Sanders Medical Pharmacology at a Glance - 6 udgave Farmakologi - Inge Olsen Den Præhospitale Patient  - Kim Dalgaard, Kenneth Lücbke m.fl. FOAMmedicPHARMA QUIZ Spørgsmål og svar fra sidste episode om Ondansetron er Spørgsmål:Hvilket medikament vi medbringer i ambulancen, udover ondansetron, har også en veldokumenteret effekt på kvalme?Svaret: Tavegyl/Clemastin Vi har trukket lod blandt de rigtige besvarelser og Vinderen af Ondansetron quizzen er Imran Khan. Imran er Ambulanceassistent og der er en lækker FOAMmedic præmie på vej til ham. Stort tillykke vi kontakter Imran for nærmere information for levering af præmien. Spørgsmålet i quizzen i denne episode af FOAMmedicPHARMA om Midazolam er: I kølvandet på 9/11 forsøgte den amerikanske efterretningstjeneste CIA, med alle midler at finde og jage terrorister i både ind og udland. Historien her fortæller at læger ansatte af CIA, i perioden fra 2002 til 2007, forsøgte sig med forskellige medikamenter der kunne fungere som sandhedsserum, for at fravriste tilfangetagne potientielle terrorister viden og information, der kunne føre til flere anholdelser eller bremse eventuelle terrorangreb. Projektet, der blev kaldt “project medication” var aldrig blevet godkendt af justitsministeriet, men udført alligevel. Disse læger forsøgte sig blandt andet med midazolam. Men spørgsmålet er her: under hvilket handelsnavn benyttede lægerne i CIA midazolam? Kender du svaret på spørgsmålet så svaret i en mail med emnet Quiz til FOAMmedic.org@gmail.com

This week on MIA Radio, we present a special episode of the MIA podcast to join in the many events being held for World Benzodiazepine Awareness Day, July 11, 2019. 2019 represents the fourth annual awareness day and each year it’s held on July 11 which is a significant date because it is the birthday of Professor Heather Ashton. Dr. Ashton is a world-leading expert in benzodiazepines and wrote the highly regarded Ashton Manual which aims to aid clinicians and patients in coming off benzodazepine drugs safely. She also spent many years personally assisting and supporting those who had experienced protracted benzodiazepine withdrawal. Around the world there are many activities and events taking place as part of W-BAD, so to follow along with events and to get involved yourself, head over to World Benzodiazepine Awareness Day’s Facebook page and look out for the hashtag #WorldBenzoDay on social media. In our two-part podcast, we hear from W-BAD volunteer and Project Manager for W-BAD Rocks of Kindness, Janelle. We also chat with physician and Director of the Benzodiazepine Information Coalition Christy Huff MD. Finally, in part two, we hear from Stephen Wright MD, addiction specialist and medical consultant to the Alliance for Benzodiazepine Best Practices. W-BAD Rocks on Facebook Rockin’ Against Benzos (closed Facebook group) A Rockin’ Creative Outlet That’s Raising Benzodiazepine Awareness #WBADROCKS – 1 Month, 5 Things We’ve Learned W-BAD Rocks on Twitter and Instagram: @wbadrocks On social media, look for the hashtag #WBADROCKS A Xanax Prescription That Should Have Been Rejected 10 Tips To Help Patients Through Benzodiazepine Withdrawal Follow Dr. Huff on Twitter Dr. Huff’s Blogs and Media Appearances (Scroll down below her bio and click on logos) BIC on Facebook @bzinfocoalition BIC on Twitter @BZInfoCoalition The Alliance for Benzodiazepine Best Practices Benzodiazepine Related Problems: It’s Almost Never Addiction Benzodiazepines and Z Drugs for Pain Patients: The Problem of Protracted Withdrawal Symptoms (PWS) How Chronic Administration of Benzodiazepines Leads to Unexplained Chronic Illnesses: A Hypothesis

This week on MIA Radio, we present a special episode of the MIA podcast to join in the many events being held for World Benzodiazepine Awareness Day, July 11, 2019. 2019 represents the fourth annual awareness day and each year it’s held on July 11 which is a significant date because it is the birthday of Professor Heather Ashton. Dr. Ashton is a world-leading expert in benzodiazepines and wrote the highly regarded Ashton Manual which aims to aid clinicians and patients in coming off benzodazepine drugs safely. She also spent many years personally assisting and supporting those who had experienced protracted benzodiazepine withdrawal. Around the world there are many activities and events taking place as part of W-BAD, so to follow along with events and to get involved yourself, head over to World Benzodiazepine Awareness Day’s Facebook page and look out for the hashtag #WorldBenzoDay on social media. In our two-part podcast, we hear from W-BAD volunteer and Project Manager for W-BAD Rocks of Kindness, Janelle. We also chat with physician and Director of the Benzodiazepine Information Coalition Christy Huff MD. Finally, in part two, we hear from Stephen Wright MD, addiction specialist and medical consultant to the Alliance for Benzodiazepine Best Practices. W-BAD Rocks on Facebook Rockin’ Against Benzos (closed Facebook group) A Rockin’ Creative Outlet That’s Raising Benzodiazepine Awareness #WBADROCKS – 1 Month, 5 Things We’ve Learned W-BAD Rocks on Twitter and Instagram: @wbadrocks On social media, look for the hashtag #WBADROCKS A Xanax Prescription That Should Have Been Rejected 10 Tips To Help Patients Through Benzodiazepine Withdrawal Follow Dr. Huff on Twitter Dr. Huff’s Blogs and Media Appearances (Scroll down below her bio and click on logos) BIC on Facebook @bzinfocoalition BIC on Twitter @BZInfoCoalition The Alliance for Benzodiazepine Best Practices Benzodiazepine Related Problems: It’s Almost Never Addiction Benzodiazepines and Z Drugs for Pain Patients: The Problem of Protracted Withdrawal Symptoms (PWS) How Chronic Administration of Benzodiazepines Leads to Unexplained Chronic Illnesses: A Hypothesis

Do you know much about the cognitive effects of benzodiazepines and Z-drugs? Perhaps you should. Memory loss, cognitive dysfunction, and intrusive memories are all possible symptoms of benzo use and withdrawal. In today's episode, we talk about the damage benzodiazepines and Z-drugs can inflict on our mental capacity. We also hear a benzo story from England, answer a question about GABA receptors, and learn what it really feels like to heal. BTW, it feels good. https://www.easinganxiety.com/post/benzo-brain-cognitive-dysfunction-and-memory-loss-in-withdrawal-bfp017Video ID: BFP017 Chapters 00:00 Introduction11:42 Mailbag13:39 Benzo News15:50 Benzo Story20:33 FEATURE: Benzo Brain40:54 Moment of Peace  Resources The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Easing Anxiety of the resource or any recommendations or advice provided therein. BENZO NEWS TECH INSIDER: “What Happens When You Take Xanax?” (VIDEO)BIC: “Why Prescribed Benzo Patients Shouldn't Go to Detox or Rehab,” by Nicole LambersonBENZO FREE PODCAST – Episode #16: “The Assault on Our Senses: Benzo Withdrawal Symptoms of the Eyes, Ears, Nose, and Mouth”MPR: “FDA: Boxed Warning, Contraindication Added to Several Insomnia Medications,” by Diana ErnstHEALTH EUROPA: “Newly uncovered gene mutation has the ability to reduce fear and anxiety”BENZO FREE: “The Missing Message: New FDA Boxed Warning for Z-drugs,” by D E Foster FEATURE: Benzo Brain Ashton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.Barker, M.J., K.M. Greenwood, M. Jackson, S.F. Crowe. “Cognitive Effects of Long-Term Benzodiazepine Use: A Meta-Analysis.” CNS Drugs 18(1)(2004):37-48. Accessed March 6, 2017. https://www.ncbi.nlm.nih.gov/pubmed/14731058.Doyle, Chase, “Benzodiazepine Exposure Can Predict Delirium in Critically Ill Children,” Anesthesiology News, October 13, 2016, accessed October 13, 2016, http://www.anesthesiologynews.com/Clinical-Anesthesiology/Article/10-16/Benzodiazepine-Exposure-Can-Predict-Delirium-in-Critically-Ill-Children/38055.Foster, D E. Benzo Free: The World of Anti-Anxiety Drugs and the Reality of Withdrawal. Erie, Colorado: Denim Mountain Press, 2018. https://easinganxiety.com/book. Guina, Jeffrey, and Brian Merrill. “Benzodiazepines I: Upping the Care on Downers: The Evidence of Risks, Benefits and Alternatives.” Journal of Clinical Medicine 7(2)(February 2018):17. Accessed July 12, 2018. doi: 10.3390/jcm7020017.Gorenstein, C., M. A. Bernik and S. Pompéia. “Differential Acute Psychomotor and Cognitive Effects of Diazepam on Long-Term Benzodiazepine Users.” International Clinical Psychopharmacology 9(3)(1994):145-53. Accessed March 6, 2017. doi:10.1097/00004850-199409000-00002.Hunt, Liz and Glenn Frankel, “Britain Takes Halcion Sleeping Pills off the Market,” Washington Post, October 3, 1991, accessed April 8, 2018, https://www.washingtonpost.com/archive/politics/1991/10/03/britain-takes-halcion-sleeping-pills-off-the-market/21d83dc2-2260-440d-96d1-7da13ceb0198/?utm_term=.e008daa4566c.Tata, P.R., J. Rollings, M. Collins, A. Pickering and R. R. Jacobson. “Lack of Cognitive Recovery Following Withdrawal from Long-Term Benzodiazepine Use.” Psychological Medicine 24(1)(February 1994):203-13. Accessed April 15, 2018. doi:10.1017/S0033291700026969.U.S. Department of Veteran's Affairs (VA/DoD). PTSD: National Center for PTSD: Use of Benzodiazepines for PTSD in Veterans Affairs. Accessed June 21, 2017. https://www.ptsd.va.gov/professional/treat/txessentials/benzos_va.asp.  Introduction In today's intro, I was feeling good — and I shared that with the listeners. My healing has been progressing and I'm now, ever so slowly, getting my life back. Actually, I'm getting a better life than I had. And I wanted to share that with the listeners as a reminder that healing does take place and there are good things on the other side. I also talked about limited the length of the podcast episodes down to 45 minutes or so. I felt that they were getting too long and I explained that this might include making some sections periodic.  Mailbag This is where we share questions and comments which were discussed: QUESTION: Do Your GABA Receptors Heal During Titration?This comment was from Kathy in Colorado, USA. She wanted to know if her GABA receptors were healing during titration (or taper). I told her they probably were and that when you start reducing the amount of drug in your body, homeostasis kicks in again and starts the rebalancing effect— but this process can take a very long time.  Benzo Story Today's story was from a Nancy in England.  Feature Today's featured topic: Benzo Brain: Cognitive Dysfunction and Memory Loss in Withdrawal. This was the fifth installment in our 14-part series on benzo withdrawal symptoms. It focused on cognitive effects of benzo withdrawal which included cognitive dysfunction, memory loss, and intrusive memories. I discussed each symptom at length and included several references which can be seen in our links above  The PodcastThe Benzo Free Podcast provides information, support, and community to those who struggle with the long-term effects of anxiety medications such as benzodiazepines (Xanax, Ativan, Klonopin, Valium) and Z-drugs (Ambien, Lunesta, Sonata). WEBSITE: https://www.easinganxiety.comMAILING LIST: https://www.easinganxiety.com/subscribe YOUTUBE: https://www.youtube.com/@easinganx DISCLAIMERAll content provided by Easing Anxiety is for general informational purposes only and should never be considered medical advice. Any health-related information provided is not a substitute for medical advice and should not be used to diagnose or treat health problems, or to prescribe any medical devices or other remedies. Never disregard medical advice or delay in seeking it. Please visit our website for our complete disclaimer at https://www.easinganxiety.com/disclaimer. CREDITSMusic provided / licensed by Storyblocks Audio — https://www.storyblocks.com Benzo Free Theme — Title: “Walk in the Park” — Artist: Neil Cross PRODUCTIONEasing Anxiety is produced by…Denim Mountain Presshttps://www.denimmountainpress.com ©2022 Denim Mountain Press – All Rights Reserved

Do you know much about the cognitive effects of benzodiazepines and Z-drugs? Perhaps you should. Memory loss, cognitive dysfunction, and intrusive memories are all possible symptoms of benzo use and withdrawal.In today's episode, we talk about the damage benzodiazepines and Z-drugs can inflict on our mental capacity. We also hear a benzo story from England, answer a question about GABA receptors, and learn what it really feels like to heal. BTW, it feels good. Welcome to Episode #17 Today we focus on the withdrawal symptoms associated with cognition. These include cognitive dysfunction, memory loss, and intrusive memories. We talk about the causes and provide a few tips on dealing with these drawn-out group of symptoms. We also hear a benzo story from England learn about when GABA receptors start to heal. But first, let's list the resources used in this episode, and then we'll dive deeper into the content of episode 17. Episode Resources The following resource links are provided as a courtesy to our listeners. They do not constitute an endorsement by Benzo Free of the resource or any recommendations or advice provided therein. BENZO NEWSTECH INSIDER: "What Happens When You Take Xanax?" (VIDEO)BIC: "Why Prescribed Benzo Patients Shouldn't Go to Detox or Rehab," by Nicole LambersonBENZO FREE PODCAST - Episode #16: "The Assault on Our Senses: Benzo Withdrawal Symptoms of the Eyes, Ears, Nose, and Mouth"MPR: "FDA: Boxed Warning, Contraindication Added to Several Insomnia Medications," by Diana ErnstHEALTH EUROPA: "Newly uncovered gene mutation has the ability to reduce fear and anxiety"BENZO FREE: "The Missing Message: New FDA Boxed Warning for Z-drugs," by D E Foster FEATURE: Benzo BrainAshton, C. Heather. Benzodiazepines: How They Work and How to Withdraw (aka The Ashton Manual). 2002. Accessed April 13, 2016. http://www.benzo.org.uk/manual.Barker, M.J., K.M. Greenwood, M. Jackson, S.F. Crowe. "Cognitive Effects of Long-Term Benzodiazepine Use: A Meta-Analysis." CNS Drugs 18(1)(2004):37-48. Accessed March 6, 2017. https://www.ncbi.nlm.nih.gov/pubmed/14731058.Doyle, Chase, "Benzodiazepine Exposure Can Predict Delirium in Critically Ill Children," Anesthesiology News, October 13, 2016, accessed October 13, 2016, http://www.anesthesiologynews.com/Clinical-Anesthesiology/Article/10-16/Benzodiazepine-Exposure-Can-Predict-Delirium-in-Critically-Ill-Children/38055.Foster, D E. Benzo Free: The World of Anti-Anxiety Drugs and the Reality of Withdrawal. Erie, Colorado: Denim Mountain Press, 2018. http://www.benzofree.org/book.Guina, Jeffrey, and Brian Merrill. “Benzodiazepines I: Upping the Care on Downers: The Evidence of Risks, Benefits and Alternatives.” Journal of Clinical Medicine 7(2)(February 2018):17. Accessed July 12, 2018. doi: 10.3390/jcm7020017.Gorenstein, C., M. A. Bernik and S. Pompéia. "Differential Acute Psychomotor and Cognitive Effects of Diazepam on Long-Term Benzodiazepine Users." International Clinical Psychopharmacology 9(3)(1994):145-53. Accessed March 6, 2017. doi:10.1097/00004850-199409000-00002.Hunt, Liz and Glenn Frankel, "Britain Takes Halcion Sleeping Pills off the Market," Washington Post, October 3, 1991, accessed April 8, 2018, https://www.washingtonpost.com/archive/politics/1991/10/03/britain-takes-halcion-sleeping-pills-off-the-market/21d83dc2-2260-440d-96d1-7da13ceb0198/?utm_term=.e008daa4566c.Tata, P.R., J. Rollings, M. Collins, A. Pickering and R. R. Jacobson. "Lack of Cognitive Recovery Following Withdrawal from Long-Term Benzodiazepine Use." Psychological Medicine 24(1)(February 1994):203-13. Accessed April 15, 2018. doi:10.1017/S0033291700026969.U.S. Department of Veteran's Affairs (VA/DoD). PTSD: National Center for PTSD: Use of Benzodiazepines for PTSD in Veterans Affairs. Accessed June 21, 2017. https://www.ptsd.va.gov/professional/treat/txessentials/benzos_va.asp. BENZO FREE LINKSWebsitePodcast Home PageFeedback FormDisclaimer Podcast Summary

Histaminintoleranz Worauf achten... Erstens: Darmprobleme können eine Histaminintoleranz auslösen: Deshalb: Bitterstoffe zum entgiften: Glutenfreie Unterstützung und Regeneration sämtlicher Verdauungsorgane: https://amzn.to/2DhMUbc Probiotika um die Darmflora aufzubauen https://amzn.to/2E2zhNb Eine zuckerarme bis freie, weissmehlfreie Ernährung Zweitens: Ein Vitalstoffmangel: Siehe Histaminintoleranz - Video Teil2 Drittens: Medikamente verstärken eine Histaminintoleranz: z.B. Diazepam: auch Schlaf und Beruhigungsmittel genannt, Metronidazol (ein Antibiotikum mit immunsupressiver und entzündungshemmender Wirkung, wird oft bei Rosacea verwendet) und Lorcainid gegen Herzrhytmusstörungen. Viertens: Vermeide Alkohol Fünftens: Vermeide alle Lebensmittel die einen bakteriellen Reifeprozess durchmachen wie z.B. fermentiertes Gemüse... Sechtens: Teste ob Du auf biogene Amine reagierst wie z.B. Schokolade, Zitrusfrüchte, Orangen, Erdbeeren und Tomaten Hallo und Herzlich Willkommen zu einer neuen Folge von Gesundheit next Level. Für viele ist ein Glas Rotwein am Abend purer Genuss. Für andere wiederum wird dadurch Hautausschlag, Erbrechen, Kurzatmigkeit, Magenkrämpfe usw. ausgelöst. Wenn jemand den Wein nicht verträgt kann es drei Ursachen haben. Eine Alkohol-Unverträglichkeit, der Schwefel im Wein oder eine Histaminintoleranz. Heut geht es uns um die Histaminintoleranz. Histamine sind im Grunde genommen natürliche Substanzen die sich sogar in vielen Lebensmitteln befinden. Wenn wir eine Entzündung haben, dann sorgt das Histamin dafür, das die Stelle anschwillt, so kann der entzündete Bereich besser durchblutet werden und Abwehrzellen besser reinkommen. Bei einer Allergie wird zu viel Histamin ausgeschüttet, es kommt zum Histaminüberschuss. Bei einer Histaminintoleranz ist es anders. Hier wird vom Körper nicht zu viel Histamin ausgeschüttet. Der Organismus kann das mit der Nahrung hereinkommende Histamin einfach nicht ordnungsgemäß abbauen. Die Abbaumechanismen funktionieren nicht richtig. Und so kommt es zum Histaminüberschuss. Normalerweise werden Histamine von den Enzymen Diaminoxidase abgebaut. Diese Enzyme werden in den Zellen der Darmschleimhaut gebildet. Haben wir eine Histaminintoleleranz können unterschiedliche Probleme vorliegen. Erstens: Darm-Probleme Wenn die Dramschleimhaut gestört ist, wird nicht genug das Enzym Diaminoxidase produziert. Eine Darmschleimhautstörung kann durch eine Weissmehl und zuckerbelastete Ernährung entstehen, oder nach Antibiotikatherapien wenn die Darmflora gestört ist. Eine Darmsanierung mit Bitterstoffen und Probiotika und eine zuckerreduzierte, weissmehlfreie Ernährung kann hier helfen. Zweitens: Ein Vitalstoffmangel kann eine Histaminintoleranz verursachen. Es wird noch ein zweites Video geben. Die wichtigsten Vitalstoffe gegen eine Histaminintoleranz seht ihr im nächsten Video. Drittens: Medikamente verstärken eine Histaminintoleranz. z.B. Diazepam: auch Schlaf und Beruhigungsmittel genannt, Metronidazol (ein Antibiotikum mit immunsupressiver und entzündungshemmender Wirkung, wird oft bei Rosacea verwendet) und Lorcainid gegen Herzrhytmusstörungen. Viertens: Alkohol. Es hemmt das Enzym Diaminoxidase und erhöht die Durchlässigkeit der Darmwand. Fünftens: Lebensmittel die Probleme machen. Es sollte nicht nur der Rotwein gemieden werden, sondern geräucherter Fisch, lang gereifte Käsesorten, Fischkonserven, fermentirtes Gemüse z.B. Sauerkraut. Fermentierte Sojaprodukte, Essig besondrs Balsamico, Hefepasten und viele Wurstsorten. Also Lebensmittel die einen bakteriellen Reifeprozess durchmachen. Sechtens: Es gibt noch ein Stoff der ebenfalls eine Histaminintoleranz auslösen kann und zwar die biogenen Amine. Diese sind in Schokolade, Zitrusfrüchten Orangen Zitronenenthalten. Auch Erdbeeren und Tomaten und Meeresfrüchte gehören dazu. Doch hier sollte man vorsichtig austesten. Weil manche vertragen sie andere wiederum nicht. Ich hoffe Dir hat das aufschlussreiche Video gefallen. Zeig es mit einem Daumen hoch. Und falls Du das Video mit den wichtigen Nährstoffen bei einer Histaminintoleranz nicht verpassen willst, abonniere hier unten rechts den Kanal. Nicht vergessen die Glocke zu drücken. Und hier unten verlinke ich Dir stichpunktartig die Tipps. Bis zum nächsten Video. Alles gute Ciau., Histaminintoleranz Worauf achten... Erstens: Darmprobleme können eine Histaminintoleranz auslösen: Deshalb: Bitterstoffe zum entgiften: Glutenfreie Unterstützung und Regeneration sämtlicher Verdauungsorgane: https://amzn.to/2DhMUbc Probiotika um die Darmflora aufzubauen https://amzn.to/2E2zhNb Eine zuckerarme bis freie, weissmehlfreie Ernährung Zweitens: Ein Vitalstoffmangel: Siehe Histaminintoleranz - Video Teil2 Drittens: Medikamente verstärken eine Histaminintoleranz: z.B. Diazepam: auch Schlaf und Beruhigungsmittel genannt, Metronidazol (ein Antibiotikum mit immunsupressiver und entzündungshemmender Wirkung, wird oft bei Rosacea verwendet) und Lorcainid gegen Herzrythmusstörungen. Viertens: Vermeide Alkohol Fünftens: Vermeide alle Lebensmittel die einen bakteriellen Reifeprozess durchmachen wie z.B. fermentiertes Gemüse... Sechstens: Teste ob Du auf biogene Amine reagierst wie z.B. Schokolade, Zitrusfrüchte, Orangen, Erdbeeren und Tomaten

smart clinics. smart quizzing. smart bins.    Comments on the pod? Ideas for future pod chat? Email - deadclicpod@outlook.com

Jamie Durrani introduces one of the biggest selling pharmaceuticals in history, the 'mother's little helper': Diazepam

Off the Hook Radio celebrated the US Olympic team and especially our woman who are kicking butt. Pokemon deaths and lawsuits. Vacationers in Afghanistan shocked they were attacked (no cure for stupid) and Hilly’s health. Diazepam for everyone! The Pod:  

The post Diazepam (Valium) appeared first on NURSING.com.

Three Tiered Therapy. Ollie Flower gives an enthralling history of seizures throughout the ages and expertly outlines the management options for terminating status.

The 67th Book Slam podcast is brought to you directly (and literally) from the studio floor. Guests include our founder, BEN WATT, of Everything But The Girl fame, reading from and discussing his extraordinary memoir, 'Romany And Tom', poetry from the brilliant WILL BURNS, stunning music from ANOUSHKA LUKAS, and a little snippet of our favourite Beard, FRANCESCA BEARD. Patrick is high on Tramadol and Diazepam, Elliott's high on life.

Did you know that you can't slip someone a valium? Well, you could, but it wouldn't be effective. This is important if you're trying to secretly get someone to relax. Note this is not exactly the placebo, because there's an element of subject awareness to the effectiveness, apparently. It's pretty fucking confusing, and perhaps (what do you know?) bullshit. How about that? Maybe part of the standard placebo trialing should involve subterfuge. We think Hrobjartsseon and Gotzsche have a lot to answer for, not least an explanation for some alternative delivery mechanisms for diazepam. If you want to explain yourselves, fellas, email us (maskedman@limitedappeal.net). Theme music courtesy of General Patton vs. The X-Ecutioners and Ipecac Recordings.

Did you know that you can't slip someone a valium? Well, you could, but it wouldn't be effective. This is important if you're trying to secretly get someone to relax. Note this is not exactly the placebo, because there's an element of subject awareness to the effectiveness, apparently. It's pretty fucking confusing, and perhaps (what do you know?) bullshit. How about that? Maybe part of the standard placebo trialing should involve subterfuge. We think Hrobjartsseon and Gotzsche have a lot to answer for, not least an explanation for some alternative delivery mechanisms for diazepam. If you want to explain yourselves, fellas, email us (maskedman@limitedappeal.net). Theme music courtesy of General Patton vs. The X-Ecutioners and Ipecac Recordings.

Die neuronalen Grundlagen individueller Unterschiede im Angstverhalten sowie die biologischen Ursachen pathologischer Angst sind bisher weitgehend unerforscht. Ein geeignetes Forschungsmodell stellen die Rattenlinien HAB (high anxiety-related behavior) und ihr Gegenstück LAB (low anxiety-related behavior) dar, die durch selektive Züchtung nach dem Kriterium ihres Verhaltens in einem Angsttest für Nager aus einer Normalpopulation hervorgegangen sind. Das Benzodiazepin Diazepam wirkt bei HAB-Ratten wesentlich stärker anxiolytisch als bei LAB-Ratten. Man kann daraus folgern, daß Diazepam differentiell auf Hirnregionen wirken muß, die Angstverhalten steuern. In umgekehrter Logik sollte eine Region, für die gezeigt werden kann, daß sie von Diazepam unterschiedlich angesprochen wird, eine Rolle in der extrem unterschiedlichen Regulation des Angstverhaltens bei den beiden Linien spielen. Zur Identifizierung dieser Kandidatenregionen wurde eine neue Methode zur Kartierung von Hirnaktivierungänderungen, die pharmakologische funktionelle Magnetresonanztomographie (phMRI), erstmals in einem Tomographen der Feldstärke 7 Tesla etabliert. Methodische Besonderheiten der hohen Feldstärke wurden untersucht. Durch den Vergleich der Hirnaktivierungsänderungen nach Diazepam-Gabe zwischen HAB- und LAB-Ratten gelang es, als wichtigste Kandidatenregion für die unterschiedliche Regulation des Angstverhalten den medialen präfrontalen Kortex und das vordere Zingulum (mPFC/ACC) zu identifizieren, eine Region, die von anderen Autoren als Angst-modulierende Region vorgeschlagen wurde. Basierend auf diesen Daten wurde die Hypothese einer Hypoaktivität des mPFC/ACC in hyperängstlichen Individuen entwickelt. Diese Hypothese kann im Tier- sowie Humanmodell getestet werden. Insbesondere ist die Untersuchung der Funktion des mPFC/ACC in Angstpatienten von Interesse, da die Charakterisierung der biologischen Substrate übersteigerten Angstverhaltens grundlegend für das Verständnis der affektiven Erkrankungen und die Entwicklung neuer Therapieansätze ist.