Podcasts about neurodegenerative diseases

When someone we know or love starts to develop psychological issues, we don't often associate it with a form of dementia. However, this trait is one of the most common signs of frontotemporal dementia (FTD) — the most common neurodegenerative disease in people under the age of 65. In his new book, Mysteries of the Social Brain: Understanding Human Behavior Through Science, Dr. Bruce Miller highlights his experiences observing people with FTD and what they have taught him about what he calls the "social brain."Dr. Bruce Miller has been observing people with FTD for decades in the Memory and Aging Center at the University of San Francisco, where he is also Professor of Neurology and the Founding Director of the Global Brain Health Institute. He shares key insights on how to keep our "social brain" healthy and how it can even unlock our creative potential.

Join us, two Registered Dietitians (and friends!), as we explore the history and science of the ketogenic diet as a miraculous therapeutic tool in the treatment of neurological disease. This is the first of two episodes about the keto diet. Next time we'll dive into the world of “Diet Culture Keto.” Same diet, very different story! Want to support the show and get bonus episodes? Join our Patreon! https://www.patreon.com/nutritionformortalsWe've got MERCH! Check it out HEREDon't want to miss any episodes in the future? Make sure to subscribe wherever you listen to podcasts!Things we talked about and additional reading: The History of Epilepsy: From Ancient Mystery to Modern MisconceptionKetogenic Diet in the Treatment of Epilepsy The Metabolic Role of Ketogenic Diets in Treating EpilepsyCharlie FoundationMillicent Kelly and the Modern History of the Ketogenic Diet First, Do No Harm starring Meryl StreepThe Effect of the Ketogenic Diet on the Therapy of Neurodegenerative Diseases and Its Impact on Improving Cognitive FunctionsEffects of ketogenic diet on cognitive function of patients with Alzheimer's diseaseMediterranean ketogenic diet… in Alzheimer's disease in humans Impact of keto diet on symptoms of Parkinson's diseaseKetogenic diet versus Mediterranean diet on glycated hemoglobin in prediabetes and T2DMFor feedback or to suggest a show topic email us at nutritionformortals@gmail.comFeel free to contact our real, live nutrition counseling practice**This podcast is for information purposes only, is not a substitute for individual medical or mental health advice, and does not constitute a patient-provider relationship**

The Benefits of Local Farm Fresh Produce and Virtual Farmers Markets: Nutritionist Leyla Muedin reveals the numerous benefits of consuming locally sourced produce through farm fresh deliveries and virtual farmers markets. Leyla emphasizes the importance of supporting local farmers and economies, the nutritional advantages of fresher and organic produce, and the convenience of having local, nutrient-dense foods delivered directly to your door. She also highlights the positive environmental impact of sustainable farming practices. The episode encourages mindful eating and explores how farm fresh deliveries can help combat food deserts and improve food security.

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Research in the past has indicated that neurological disorders such as Alzheimer's disease are non-infectious. But what if it was possible to catch a brain infection? Joining us to discuss this fascinating topic is Dr. Or Shemesh, an expert working to build and utilize new technologies to study and reverse brain disease… Dr. Shemesh is an Assistant Professor at the University of Pittsburgh School of Medicine, Departments of Neurobiology and Bioengineering. Here, he works in a cutting-edge field called “Counter Disease Engineering” – otherwise known as a technological approach to understanding diseases of the nervous system.  In this conversation, we cover: The major causes of inflammation. The unique connection between nervous system diseases and infectious agents.  How microbes impact our overall health.  How brain pathogens are potentially connected to Alzheimer's.  You can learn more about Dr. Shemesh and his work here! Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Do you know someone living with Parkinson's disease or other neurodegenerative disease? In this episode, outreach coordinator Dana Hentschel speaks with occupational therapist Jenny Williams with Optimum Hope about ways to combat some of the physical decline that comes with these types of diseases.

This episode teaches that innovation is born at the intersection of curiosity and persistence. Dr. Gudrun Stengel, co-founder and CEO of Alida Biosciences, reveals how her startup is transforming the landscape of RNA research through a novel technology called proximity barcoding. Dr. Stengel's story exemplifies the power of entrepreneurial spirit in driving scientific discovery, offering a glimpse into how one idea can reshape an entire field.At Alida Biosciences, Dr. Stengel and her team are pioneering new tools for detecting RNA modifications, a largely unexplored realm of epigenetics. Using their proximity barcoding platform, researchers can read multiple RNA modifications simultaneously, uncovering potential biomarkers and therapeutic targets for diseases like cancer, Alzheimer's, and diabetes. This technology bridges a critical gap in multiomics, allowing scientists to dive deeper into how epigenetic changes influence gene expression and cellular behavior.Beyond the lab, Dr. Stengel shares her experience as a first-time founder, balancing scientific rigor with startup life. From managing a team to fundraising, her journey underscores the importance of resilience, optimism, and maintaining a long-term vision. She also offers valuable advice for budding scientists, encouraging them to embrace challenges and remain persistent in the face of setbacks. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

Leah explores the potential connection between Alzheimer's disease and tinnitus in veterans, highlighting how both conditions—often overlooked as related—may actually share neurological links. Drawing from multiple scientific studies, Leah presents compelling evidence that tinnitus could be an early indicator or risk factor for cognitive decline and neurodegenerative diseases like Alzheimer's and Parkinson's, especially in veterans exposed to chronic stress and noise. She emphasizes the importance of discussing symptoms with medical providers and seeking support through accredited VA claims professionals, especially in complex disability cases.

On May 8, 2025 we met with Kevin Bieniek to talk about the nature of brain injury seen in chronic traumatic encephalopathy in athletes and others who experience repeated concussion. Kevin explained the commonalities and unique features of those injuries compared to neurodegenerative diseases.Guest:Kevin Bieniek, Associate Professor, Department of Pathology and Laboratory Medicine and Director of the Brain Bank at the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases at UT Health San Antonio.Participating:Melanie Carless, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

Ean Moderator: Yıldız Değirmenci (Istanbul, Türkiye)Guest: Didem Öz (Izmir,  Türkiye)In this episode, Değirmenci and Öz discuss the vital importance of brain donation in understanding and treating neurodegenerative diseases. They also highlight the Turquoise Outreach Project—a meaningful initiative that builds bridges between the community and dementia research, promoting awareness, inclusion, and progress.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely already an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password'-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department (membership@ean.org) to cross-check if you are listed as an Associate Member to get access to eanCampus.

Send us a textIn this milestone episode of The Daily Apple, Kevin and Brian take a victory lap (at a very healthy heart rate, of course) as they celebrate one full year of talking all things health and wellness! They look back on the journey—from early awkward recordings to rubbing elbows with health experts at the Live Long Conference—and share some of the biggest lessons they've learned along the way.The guys dive into why cardiovascular health is kind of a big deal (hint: it keeps you alive), the scary truth about soft plaque, and why heart health screenings need a serious glow-up. They also geek out over the latest breakthroughs in neurodegenerative disease research—and why early detection might just be the real MVP of health care.Plus, Kevin and Brian reflect on the power of community, collaboration, and a few mistakes made along the way (looking at you, conference coffee). They're fired up about the future of health initiatives in Oklahoma and beyond—and they're taking you along for the ride.Spoiler: It involves less waiting until you're sick and more actually knowing what's going on inside your body. Prime Health Associates

Two-thirds of those diagnosed with Alzheimer's disease are women — but why? In this episode, we unpack the neurological, hormonal, and social drivers that uniquely affect women's brain health during the menopausal transition — from estrogen's protective role in the brain to the misunderstood history of hormone replacement therapy. We discuss: • Why women face a higher risk of Alzheimer's than men • How menopause accelerates brain aging (and how it starts earlier than is often expected) • The role of estrogen in brain metabolism and neuroprotection • The real story behind hormone replacement therapy (HRT) • The impact of genes like APOE4 on women's brain health • How lifestyle factors like stress, sleep, and cognitive activity can help reduce the impact of neurological changes onset by menopause ——— Get our free curation of women's brain health resources in our Brain Box: http://thebraindocs.com/brainbox ——— To help us tell this story, we welcome three world-renowned women's health experts to the podcast: DR. LISA MOSCONI: Director of the Women's Brain Initiative, author of ‘The Menopause Brain', and pioneering researcher in brain imaging and hormonal neuroscience. MARIA SHRIVER: Founder of the Women's Alzheimer's Movement, journalist, and relentless advocate for gender equity in brain health research. DR. LISA GENOVA: Neuroscientist and bestselling author of ‘Still Alice', which was adapted into a film starring Julianne Moore, who won the  2015 Best Actress Oscar for her role as Alice Howland. This is... Your Brain On Menopause. ‘Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Menopause' • SEASON 5 • EPISODE 1 ——— Our free Women's Brain Health Brain Box includes: • Guides on how to speak with healthcare providers about menopause • Delicious brain-healthy Mother's Day brunch recipes • Meaningful gift ideas for the women you love • Inspiring interviews with world-leading women's health experts • And even a chance to check your cognitive health with an insightful, science-backed test Get the Brain Box for free! Here: http://thebraindocs.com/brainbox ——— References: Mosconi, L. (2017). Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PloS One, 12(10), e0185926.  Belloy, M. E. & Alzheimer's Disease Neuroimaging Initiative. (2019). A quarter century of APOE and Alzheimer's disease: Progress to date and the path forward. Neuron, 101(5), 820-838.  Rahman, A. (2019). Sex and gender driven modifiers of Alzheimer's: The role for estrogenic control across age, race, medical, and lifestyle risks. Frontiers in Aging Neuroscience, 11, 315.  Rocca, W. A. (2012). Hysterectomy, oophorectomy, estrogen, and the risk of dementia. Neurodegenerative Diseases, 10(1-4), 175-178.  Scheyer, O. (2018). Female sex and Alzheimer's risk: The menopause connection. Journal of Prevention of Alzheimer's Disease, 5(4), 225-230.  Women's Health Initiative Memory Study Investigators. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study—a randomized controlled trial. JAMA, 289(20), 2651–2662.  Women's Health Initiative Investigators. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA, 288(3), 321-333.  Whitmer, R. A. (2005). Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64(2), 277-281.  Livingston, G. (2024). Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. The Lancet, 404(10452), 572-628. Maki, P. M. (2016). Hormone therapy, dementia, and cognition: The Women's Health Initiative 10 years on. Climacteric, 19(3), 313-315. 

Michael Hughes is a postdoctoral researcher at St. Jude's Children's Hospital who studies the overlooked role of water in living systems. His work builds on a growing body of research suggesting that water is not just a passive solvent, but a highly structured, information-rich medium. Hughes proposes that under normal biological conditions, water's ability to form liquid crystalline phases, hydration shells, and coherent domains allows it to act more like an information storage system than an inert backdrop to biochemistry. Drawing on ideas like EZ water, interfacial water dynamics, and liquid-liquid phase separation inside cells that span thinkers from Gilbert Ling to Gerald Pollack, Hughes argues that health emerges from the fine-tuned electrical and structural properties of intracellular water. When this water-protein-electrical system breaks down, disease can result. He outlines a new approach to the body that's rooted in biophysics, not just molecular biology, which he believes might offer novel ways to maintain health and slow aging by restoring the electromagnetic coherence of the body.MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showPreprint of Michael's manuscript "Rethinking Cellular Organization: Phase Separation as a Unifying Principle in Molecular Biology" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5171413Dr. Thomas Seyfried podcast w/ DemystifyScihttps://www.youtube.com/watch?v=rxHkXP3G3y4"Live Streaming of a Single Cell's Life over a Local pH Monitoring Nanowire Waveguide" https://pubs.acs.org/doi/10.1021/acs.nanolett.2c02185Rudolf Steiner's Agriculture Course: https://www.youtube.com/watch?v=fwSa8Lpy9-A 00:00 Go! 00:09:54 – Water, Fields & the Electric Body 00:15:01 – Biochemistry's Unifying Principles 00:21:26 – Water, Glutamine & Metabolism 00:23:02 – Liquid-Liquid Phase Separation 00:25:34 – Hydration & Cellular Structure 00:28:08 – Amyloids in Health & Disease 00:33:52 – Environment Shapes Amyloids 00:39:37 – Osmosis, Metabolism & Flow 00:41:04 – Soil Over Seed: Health Revolution 00:42:24 – Evolving Scientific Paradigms 00:46:08 – Cell Theory & Liquid Separation 00:50:34 – Rethinking Genetic Primacy 00:56:12 – Biochemical Research Challenges 01:01:58 – Terrain Theory & Post-Pandemic Trust 01:13:16 – Technology, Ethics & Evolution 01:16:06 – Metabolism as Societal Metaphor 01:21:09 – Lifespan, Healthspan & Food Systems 01:23:25 – Terrain Theory & Neurodegenerative Disease 01:25:10 – pH, Buffers & Biochemical Balance 01:30:03 – Cellular Function & pH Dynamics 01:35:17 – Biochemical Cell Environment 01:39:06 – Intracellular Phase Separation 01:43:07 – Insulin, Gradients & Phase Transitions 01:45:12 – Water, Food & Environmental Impacts 01:48:14 – Personal Diet & Exercise Design 01:57:09 – Experimenting with Your Health 02:00:11 – Dyno comp! #electricuniverse #biochemistry, #structuredwater , #cellularhealth, #watermemory, #metabolism, #quantumhealth, #naturalmedicine, #integrativemedicine, #nutritionalscience, #epigenetics, #philosophypodcast, #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

In this episode, I'm joined by Dr. Dale Bredesen, a true pioneer in Alzheimer's research and functional medicine. Together, we dive into groundbreaking advancements in the world of neurodegenerative diseases, with a special focus on the exciting breakthroughs in detecting and potentially reversing Alzheimer's and other related conditions. Dr. Bredesen sheds light on the new disease mechanisms and innovative blood tests that are changing the game, showing us that cognitive decline isn't something we simply have to accept. We also explore his integrative approach to combating Alzheimer's, which includes lifestyle modifications, early detection, and a holistic strategy for better brain health. This conversation is packed with hope and real strategies for a future where Alzheimer's doesn't have to be inevitable. Key Takeaways: New Era of Research: Alzheimer's and similar neurodegenerative diseases are not death sentences, thanks to innovative research and new treatment protocols that emphasize early detection and intervention. Significance of Gut Health: Investigations reveal that gut microbiota and inflammation are crucial risk factors in cognitive decline, underscoring the importance of gut health in preventing Alzheimer's. Role of Lifestyle Changes: Diet, exercise, sleep, and stress management are integral to maintaining brain health and can significantly influence the progression of neurodegenerative diseases. Advance in Diagnostics: Cutting-edge blood tests such as P Tau217 and brain scans can detect early signs of Alzheimer's up to 20 years prior to diagnosis, offering opportunities for preemptive action. The Power of Personalized Medicine: Individualized protocols based on genetic testing, like assessing APOE status, are pivotal in developing effective prevention and treatment strategies for cognitive disorders. More About Dr. Dale Bredesen: Dr. Dale Bredesen, M.D., is a globally recognized expert in neurodegenerative diseases, particularly Alzheimer's disease. With a background that includes graduating from Caltech and earning his M.D. from Duke University Medical Center, Dr. Bredesen's career is marked by groundbreaking research and clinical expertise. He completed his residency as chief resident in neurology at UCSF and further honed his skills at Nobel laureate Stanley Prusiner's lab at UCSF as an NIH postdoctoral fellow. Dr. Bredesen's academic career includes faculty positions at prestigious institutions like UCSF, UCLA, and UC San Diego. As the founding president and CEO of the Buck Institute for Research on Aging, he spearheaded pioneering work in the study of aging and neurodegenerative diseases. Currently, he serves as the chief medical officer of MPI Cognition, where he continues his innovative research and efforts to combat Alzheimer's and related conditions. Dr. Bredesen's expertise and leadership have made him a key figure in the field, with a focus on integrative approaches to prevent and reverse cognitive decline. His contributions are reshaping our understanding of neurodegenerative diseases, offering new hope for those affected by them. Website Instagram Take a Cognitive Assessment here: https://www.apollohealthco.com/know-your-cq/ Get a brain scan: https://getabrainscan.com/ KetoFLEX 12/3: https://www.trifectanutrition.com/apollohealthpartner Connect with me! Website Instagram Facebook YouTube   This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!

World-renowned integrative physician Lee Cowden, MD, guided us toward better health during the M3 Detox Experience, where we examined the hidden dangers of mold, metals, and microbes toxicity and their impact on chronic illness. A pioneer in functional and holistic medicine, Dr. Cowden has been a leading force in educating practitioners worldwide and advancing natural […]

In today's episode of The Root Cause Medicine Podcast, Dr. Carrie Jones sits down with Dr. Kellyann Niotis to discuss brain health and neurodegeneration prevention. What You'll Learn: 1. Why brain health should be a priority starting in early adulthood 2. How neurodegenerative diseases begin decades before symptoms appear 3. The role of lifestyle factors in maintaining brain health 4. New blood-based biomarkers and traditional imaging methods 5. The relationship between hormones and brain health Dr. Kellyann Niotis is the first and only fellowship-trained preventive neurologist specializing in early detection and prevention of neurodegenerative diseases. As a leading expert in brain health and preventative neurology, she brings extensive experience in movement disorders and Parkinson's disease to her practice. Through her work at the Institute for Neurodegenerative Diseases in Florida, Dr. Niotis focuses on identifying and addressing neurological health concerns decades before symptoms appear. She is dedicated to transforming how we approach brain health, combining cutting-edge diagnostics with personalized prevention strategies. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

You're doing everything right. You're ambitious, successful + driven. So why is it your energy is nonexistent, patience is razor-thin + your mind can't stop overthinking? If your days are starting with dread and ending in exhaustion — this episode is your wake-up call. On paper, you've got it together— isn't it time you felt like it? Whether it's stop playing out worst case scenarios in your head or accessing your abilities in a way burnt out you could never compete with, Perfectionism Optimized, private 1-1 coaching gives you the life-long skills to *finally feel* as amazing on the inside as your life looks on the outside. Get your stress-free start today at https://courtneylovegavin.com/rewire In this Episode You'll Learn:How pushing through dewires your brain into survival modeWhat caffeine, people pleasing + Top Ramen have in common16 surprising signs your brain is starvingWhy ruminating and indecisiveness are symptoms—not problems to solveHow a healthy Person Account™ allows you to access your abilities in a way burnt out you could never compete with Resources Mentioned In Episode 253:Recharge your Person Account Book your Perfect Start 1:1 session nowMagic Skill for Control of Emotions [Neuroscience Series #1] Perfectionism Rewired Ep. 248How Perfectionist Brain *Actually* Works [Neuroscience Series #2] Perfectionism Rewired Ep. 249Can't Stop Ruminating? Here's Why [Neuroscience Series #3] Perfectionism Rewired Ep. 250Neuroplasticity  [Neuroscience Series #4] Perfectionism Rewired Ep. 251#1 Thing Stops Perfectionists From Growth [Neuroscience Series #5] Perfectionism Rewired Ep. 252  TIMESTAMPS:02:09-Why Perfectionists Need More Fuel for Our Brains04:10-MYTH: You Have to Stop Being a Perfectionist06:24-Clues You're on the Path to Chronic Stress09:32-Burn Out is Not the Price of Ambition10:25-Case Study: How Stacey found Clarity, Energy, Peace12:43-I Ruminate Over Decisions bc I Need to Make the Right Decision14:05-Why You're Choosing Instant Relief (and Paying Later)16:11-A Healthy Person Account™ = Liberation17:32-How to Always Know How Your Person Account™ is Doing  Citations/Sources:Barrett, L. F. (2017). How emotions are made: The secret life of the brain. Houghton Mifflin Harcourt.Barrett, L. F., Quigley, K. S., & Hamilton, P. (2016). An active inference theory of allostasis and interoception in depression. *Philosophical Transactions of the Royal Society B: Biological Sciences*, *371*(1708), 20160011. https://doi.org/10.1098/rstb.2016.0011Bobba-Alves, N., Juster, R.-P., & Picard, M. (2022). The energetic cost of allostasis and allostatic load. Psychoneuroendocrinology, 146, 105951. https://doi.org/10.1016/j.psyneuen.2022.105951Dwyer, P. (2022). The Neurodiversity Approach(es): What Are They and What Do They Mean for Researchers? Human Development, 66(2), 73–92. https://doi.org/10.1159/000523723Ganzel, B. L., & Morris, P. A. (2011). Allostasis and the developing human brain: Explicit consideration of implicit models. Development and Psychopathology, 23(4), 955–974. https://doi.org/10.1017/s0954579411000447‌Guidi, J., Lucente, M., Sonino, N., & Fava, Giovanni A. (2020). Allostatic Load and Its Impact on Health: A Systematic Review. Psychotherapy and Psychosomatics, 90(1), 11–27. https://doi.org/10.1159/000510696Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., Quigley, K. S., Dickerson, B. C., & Feldman Barrett, L. (2017). Evidence for a large-scale brain system supporting allostasis and interoception in humans. Nature Human Behaviour, 1(5). https://doi.org/10.1038/s41562-017-0069Knezevic, E., Katarina Nenic, Milanovic, V., & Knezevic, N. N. (2023). The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders. Cells, 12(23), 2726–2726. https://doi.org/10.3390/cells12232726‌McEwen, B. S., & Gianaros, P. J. (2011). Stress- and Allostasis-Induced Brain Plasticity. Annual Review of Medicine, 62(1), 431–445. https://doi.org/10.1146/annurev-med-052209-100430 Perfectionism Rewired is committed to truth and accuracy through a perfectionist affirming lens, offering cutting-edge research on perfectionism, interoception + neuroscience, for the practical perfectionist who wants to enjoy the life they've worked so hard to create.

On April 3, 2025 we met with Lorena Saelices to talk about what we know about the structure of amyloids, how they form by misfolding and aggregation of proteins, and how they damage cells and tissues in a range of disorders (including Alzheimer's and Parkinson's diseases). Guest:Lorena Saelices, Assistant Professor, Department of Biophysics and the Center for Alzheimer's and Neurodegenerative Diseases at the UT Southwestern Medical School.Participating:Chris Gamblin, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson , Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

Send us a textShort Summary: How environmental chemical exposures affect neurodegenerative disease and health.About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly Parkinson's and Alzheimer's diseases.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Gary Miller talks about neurodegenerative diseases like Parkinson's and Alzheimer's, exploring their age-driven nature, early detection challenges, and environmental risk factors such as pesticide exposure and head trauma. They discuss the emerging field of exposomics—studying lifetime chemical exposures—and its potential to uncover links between pollutants, diet, and disease, while highlighting protective factors like caffeine and nicotine, and the role of technology in advancing prevention and treatment.Key Takeaways:Neurodegenerative diseases like Parkinson's & Alzheimer's worsen with age, but early intervention could slow progression & improve quality of life.Parkinson's symptoms often appear after significant dopamine neuron loss, but subtle signs like handwriting changes or gait issues might be detectable earlier.Environmental factors, including pesticides & air pollution, increase neurodegeneration risk, while caffeine and nicotine surprisingly lower Parkinson's incidence.The exposome—total lifetime exposure to chemicals—offers a new lens to study health, revealing how pollutants & diet interact with our biology.Ultra-processed foods & common chemicals like PFAS (in packaging) raise exposure levels, but simple steps like air filters or less processed diets can help reduce risks.Related episode:M&M #145: Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of ASupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Tune in to the first episode of our new series, Navigating the Path: Resources for Patients with Neurodegenerative Diseases, which highlights organizations that provide resources and information to people with neurodegenerative diseases. In this episode, Lauren Corley, a National MS Society representative, joins our host Christina Burke to explore the many resources and programs offered by the society. From financial assistance for assistive devices to continuing education opportunities for clinicians, learn how the National MS Society is making a meaningful impact in the MS community. They are both joined by Gregory Brusola, a board member of the DD SIG and coordinator of the DD SIG liaison program, who discusses the role of DD SIG liaisons and connections for PTs with the National MS Society.  The Degenerative Diseases Special Interest Group is part of the Academy of  Neurologic Physical Therapy – www.neuroPT.org  For questions about this podcast, please contact neuroddsig@gmail.com.  Show notes available Visit the National MS Society website for more information on their programs 

What if one psychedelic plant could change how we approach trauma, addiction, and even neurodegenerative diseases?In this eye-opening episode of Keeping It Real, Jillian sits down with Bryan Hubbard, a leading voice in the psychedelic therapy space, to explore the power of Ibogaine therapy.Together, they take a deep dive into:How ibogaine works in the brain to disrupt addiction cycles, rewire trauma pathways, and stimulate neuroplasticity to help people with everything from sobriety to weight loss. The powerful potential of ibogaine therapy to address depression, anxiety, PTSD, and stress-related illnessWhy ibogaine may offer hope for those experiencing cognitive decline, and how it's being studied for conditions like Parkinson's disease, multiple sclerosis (MS), and Lyme diseaseThe recent Stanford University–Ambio study, published in Nature Medicine, showing remarkable improvements in veterans with traumatic brain injuries — and no serious adverse eventsWhy veterans, trauma survivors, and chronic illness patients are turning to alternative, plant-based healing modalitiesWhile ibogaine therapy remains unapproved by the FDA and is only legal in certain countries, this episode brings awareness to a growing global movement pushing the boundaries of how we understand and treat human suffering.Disclaimer: This episode is for educational and informational purposes only. Ibogaine is not FDA-approved and should not be considered medical advice. Always consult with a qualified healthcare provider.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Feel like you're working hard but not seeing the progress you want? It's NOT YOU or your PERFECTIONISM – it's your Person Account™ . Discover my proprietary framework that's changing the game for Perfectionist Solution's clients, and will do the same for you.  In this Episode You'll Learn:How ruminating + running a 10k impact you the exact same wayWhy perfectionist brains work overtime + cost more to operateHow to tell if you're operating in a constant state of depletion without realizing itWhat Cortisol actually is (it's NOT a STRESS HORMONE)The hidden reason therapy + personal development don't work On paper, you've got it together— isn't it time you felt like it? Whether it's stop playing out worst case scenarios in your head or JOYFULLY PRESENT AMBITIOUS again, Perfectionism Optimized, private 1-1 coaching gives you the life-long skills to *finally feel* as amazing on the inside as your life looks on the outside. Get your stress-free start today at https://courtneylovegavin.com/rewire Resources Mentioned In Episode 252:Perfect Start SessionMagic Skill for Control of Emotions [Neuroscience Series #1] Perfectionism Rewired Ep. 248How Perfectionist Brain *Actually* Works [Neuroscience Series #2] Perfectionism Rewired Ep. 249Can't Stop Ruminating? Here's Why [Neuroscience Series #3] Perfectionism Rewired Ep. 250  TIMESTAMPS:0:53-Why You're Not Making Progress Despite Trying Harder02:15-Allostasis: How Your Brain Allocates05:07-The Hidden Reason Therapy Isn't Working06:30-Why Perfectionist Brains Cost More to Operate07:25-Living in a Depleted State Without Realizing It09:31-Stressed out: Eustress vs. Distress10:29-Truth about Cortisol + Stress Response12:35-The Slow Drip of Perfectionist Burnout15:17-How to Tell if You're Running on Empty  Citations/Sources:Barrett, L. F. (2017). How emotions are made: The secret life of the brain. Houghton Mifflin Harcourt.Bobba-Alves, N., Juster, R.-P., & Picard, M. (2022). The energetic cost of allostasis and allostatic load. Psychoneuroendocrinology, 146, 105951. https://doi.org/10.1016/j.psyneuen.2022.105951Dwyer, P. (2022). The Neurodiversity Approach(es): What Are They and What Do They Mean for Researchers? Human Development, 66(2), 73–92. https://doi.org/10.1159/000523723Ganzel, B. L., & Morris, P. A. (2011). Allostasis and the developing human brain: Explicit consideration of implicit models. Development and Psychopathology, 23(4), 955–974. https://doi.org/10.1017/s0954579411000447‌Guidi, J., Lucente, M., Sonino, N., & Fava, Giovanni A. (2020). Allostatic Load and Its Impact on Health: A Systematic Review. Psychotherapy and Psychosomatics, 90(1), 11–27. https://doi.org/10.1159/000510696Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., Quigley, K. S., Dickerson, B. C., & Feldman Barrett, L. (2017). Evidence for a large-scale brain system supporting allostasis and interoception in humans. Nature Human Behaviour, 1(5). https://doi.org/10.1038/s41562-017-0069Knezevic, E., Katarina Nenic, Milanovic, V., & Knezevic, N. N. (2023). The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders. Cells, 12(23), 2726–2726. https://doi.org/10.3390/cells12232726‌McEwen, B. S., & Gianaros, P. J. (2011). Stress- and Allostasis-Induced Brain Plasticity. Annual Review of Medicine, 62(1), 431–445. https://doi.org/10.1146/annurev-med-052209-100430 Perfectionism Rewired is committed to truth and accuracy through a perfectionist affirming lens, offering cutting-edge research on perfectionism, interoception + neuroscience, for the practical perfectionist who wants to enjoy the life they've worked so hard to create.

Just a couple of weeks ago, 1,800 scientists, clinicians, postdoctoral fellows, and medical residents gathered in West Palm Beach, Florida, for the Americas Committee for Treatment and Research in Multiple Sclerosis annual meeting, better known as the ACTRIMS Forum. Dr. Mikael Simons is a neurologist and researcher at Technical University Munich and the Centre for Neurodegenerative Diseases in Munich, Germany, and he's this year's recipient of the Barancik Prize for Innovation in MS Research. At the ACTRIMS Forum, we talked with Dr. Simons about his research in myelin repair. We have a lot to talk about! Are you ready for RealTalk MS??! SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/actrims06 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com RealTalk MS on YouTube https://www.youtube.com/@RealTalkMS Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Bonus Episode Guest: Dr. Mikael Simons Privacy Policy

Kristen Gray is the mother of Charlotte and Gwenyth Gray, who were diagnosed with Batten disease in 2015. Kristen and her husband, film producer Gordon Gray, founded the Charlotte and Gwenyth Gray Foundation to Cure Batten Disease. Doctors explained that there was no cure, nor any treatment options for this rare neurodegenerative disorder which would leave the girls blind, immobile, cognitively impaired, and ultimately gone between the ages of 6 and 12. Kristen and Gordon were unwilling to accept this prognosis. One year later, thanks to unwavering dedication and an overwhelming outpouring of support from all over the world, they built a foundation which coordinated and funded a first of its kind investigational gene therapy clinical trial, providing the first signs of hope for a cure to families impacted by this disease. Results are ongoing, but promising. The Foundation funded the pre-clinical research and treatment of 15 children to date. Reality Life with Kate Casey What to Watch List: https://katecasey.substack.com Patreon: http://www.patreon.com/katecasey Twitter: https://twitter.com/katecasey Instagram: http://www.instagram.com/katecaseyca Tik Tok: http://www.tiktok.com/itskatecasey Facebook Group: https://www.facebook.com/groups/113157919338245 Amazon List: https://www.amazon.com/shop/katecasey Like it to Know It: https://www.shopltk.com/explore/katecaseySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today's episode of The Root Cause Medicine Podcast, we explore the often-overlooked importance of brain health and how it directly impacts our quality of life with Dr. Austin Perlmutter. You'll hear us discuss: 1. Brain inflammation 2. Brain-related conditions in women 3. Detoxification and brain health 4. Lifestyle choices supporting brain health 5. Supplements for brain health Dr. Austin Perlmutter is a board-certified internal medicine physician, a New York Times bestselling author, and a published researcher. He is also a health investor and international educator dedicated to helping people improve their health by addressing the biological roots of "stuckness" in the brain and body. Currently, Dr. Perlmutter serves as the executive director and research lead at Big Bold Health. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Send us a textShort Summary: The complexities of neurodegenerative disease, particularly Alzheimer's, environmental influences like glyphosate, and the crucial role of nutrients like choline, with actionable insights into brain health management.About the guest: Dr. Ramon Valazquez is an Assistant Professor at Arizona State University, leading a research lab at the Neurodegenerative Disease Research Center. His work focuses on environmental factors related to Alzheimer's and other dementias, alongside developing therapeutic strategies.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Ramon Velazquez explores neurodegenerative disease, with a deep dive into Alzheimer's, its pathophysiology including amyloid beta plaques and tau pathology. It examines the controversy around these proteins' roles in disease progression, the influence of environmental toxins like glyphosate on brain health, and the preventive potential of nutritional interventions, particularly choline.Key Takeaways:Neurodegenerative Disease Basics: Alzheimer's disease involves both amyloid beta plaques and tau tangles, with tau pathology more closely linked to clinical symptoms.Environmental Impact: Glyphosate, a common herbicide, can cross into the brain, potentially exacerbating neurodegenerative pathways through inflammation.Choline: Essential for brain function and fat metabolism, it's often deficient in diets, particularly plant-based ones. Adequate intake might prevent or mitigate cognitive decline and related diseases.Preventive Measures: Early nutritional intervention, like maintaining choline levels, could be vital for preventing neurodegenerative diseases. However, once symptoms are present, such interventions might not reverse existing pathology.Related episode:M&M #145: Epigenetics, HormonesSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Use your phone's link. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Dietitian's, Aidan Muir & Leah Higl, explore the relationship between creatine supplementation and cognitive function. They discuss the mechanisms by which creatine may enhance cognitive performance, and also dive into potential benefits for neurodegenerative diseases, concussions and more.    (0:00) - How Does Creatine Work? (3:02) - Creatine & Sleep Deprviation (5:31) - Memory, Attention, Focus & Problem Solving (6:57) - Neurodegenerative Diseases (9:30) - Does It Benefit Concussions? (11:34) - Summary   WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en   Our dietitians

Fri, 24 Jan 2025 00:00:00 +0000 https://seesee.podigee.io/s3e12-john-cryan f9d417dd4b9c1419db8383f62238f1f5 In this episode, we embark on a fascinating journey to explore one of the most groundbreaking areas of science - the gut-brain axis! Leading the way is none other than world-renowned neuroscientist Professor John Cryan of University College Cork, whose pioneering work has helped uncovered the powerful link between the gut microbiome and mental health and behaviour. Co-hosted by one of Europe's leading neurosurgeons, Peter Vajkoczy, this is one episode you won't want to miss. So, sit back and buckle up as we navigate the neural pathways that connect our gut to our brain, and discover how this connection plays a critical role in a wide range of conditions, from mental disorders to degenerative diseases. We'll delve into Professor Cryan's cutting-edge research, exploring the diseases his team in Cork are targeting and the innovative delivery systems they're developing to make genetic changes in the brain. You'll also hear about the forces that shape our microbiota throughout our lives, from the importance of vaginal birth and breast milk to the relationship between stress, dementia and depression, and the impact of diet on social behaviour, cognitive decline and aging, and mental health. We'll also explore the exciting new field of psychobiotics, which Cryan covers in his bestselling book, “The Psychobiotic Revolution: Mood, Food and the New Science of the Gut-Brain Connection”. Prepare to be amazed by the potential future treatments for neurological and mental health conditions through the lens of microbiota and neuroscience. Join us for an unforgettable episode as microbes and neurons bring us closer to understanding a shared universe of the gut and the brain! *Professor John F. Cryan is Vice-President for Research and Innovation at University College Cork (UCC), Professor in the Department of Anatomy and Neuroscience, and Principal Investigator at the APC Microbiome Ireland Institute. His pioneering research concentrates on the gut-brain axis and the impact of gut microbes on stress, psychiatric and immune disorders, as well as their influence on mental health. He is a leading figure in this field, with numerous influential publications and significant contributions to scientific research and public understanding of the microbiome. He has published over 600 peer-reviewed articles and has served as co-editor for several books. Additionally, he currently serves as Editor-in-Chief of Neuropharmacology and Neurobiology of Stress, and is a member of the editorial boards of 15 other scientific journals. **This episode is cohosted by Prof. Peter Vajcokzy. He has been Head of Neurosurgery at Charité-Universitätsmedizin in Berlin since 2007. He leads 5,000 brain surgeries a year, 800 of which he performs. He is a full professor at Charité and an associate professor at Heidelberg. He treats cerebrovascular disorders, brain tumours, skull base tumours and performs minimally invasive spine and peripheral surgery. He also performs functional neurosurgery and pain management procedures. His research focuses on brain cancer and the mechanisms of brain tumours. He also studies the monitoring of neocortically ill patients after vessel occlusion. https://publish.ucc.ie/researchprofiles/C003/jcryan Social Media: John F. Cryan (@jfcryan) · X https://scholar.google.com/citations?user=3SiQStcAAAAJ&hl=en https://www.amazon.com/Books-John-F-Cryan/s?rh=n%3A283155%2Cp_27%3AJohn+F.+Cryan TEDMED Food for thought: How gut microbes change your mind https://www.youtube.com/watch?v=kMVxbnfSP-Q Feed Your Microbes - Nurture Your Mind | John Cryan | TEDxHa'pennyBridge https://www.youtube.com/watch?v=vKxomLM7SVc NETFLIX Documentary: “Hack your Health” featuring Prof. John Cryan https://www.netflix.com/tudum/articles/hack-your-health-secrets-of-your-gut-release-date-trailer-news Grandmaternal stress and during pregnancy and DNA Germany/ Brazil and Sweden) (Paper published in 2017 Serpeloni F, Radtke K, de Assis SG, Henning F, Nätt D, Elbert T. Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study. Transl Psychiatry. 2017 Aug 15;7(8):e1202. doi: 10.1038/tp.2017.153. PMID: 28809857; PMCID: PMC5611722. https://pubmed.ncbi.nlm.nih.gov/28809857/ 3 12 full no Gut-brain axis,Gut Microbiome,Microbiome,Mental health,Neuroscience,Neurobiology,Gut-brain connection,Psychobiotics,Neurodegenerative diseases,Microbiota Dr. Cecilia Ponce Rivera

Nutrition Nugget! Bite-size bonus episodes offer tips, tricks and approachable science. This week, Jenn is talking about the surprisingly sweet health benefits of dates. Have you ever wondered how something so sweet could be good for you? While dates may pack quite a punch in carbs—75 grams of carbs in just four dates—they're also full of fiber, antioxidants, and essential minerals. Join Jenn as she breaks down why you might want to incorporate these dates into your diet, how to use them in recipes, and why portion size matters when enjoying their health benefits. Like what you're hearing? Be sure to check out the full-length episodes of new releases every Wednesday.  Have an idea for a nutrition nugget?  Submit it here: https://asaladwithasideoffries.com/index.php/contact/       RESOURCES: Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNew Year - Healthier YouNutrition Nugget: Antioxidants

Dan Levendowski, Co-Founder and President, and Chris Berka, Co-Founder and CEO of Advanced Brain Monitoring, have developed medical devices that measure brain activity through electroencephalography (EEG) during awake and sleeping states. These easy-to-use EEG devices can be used at home and in a clinic to identify biomarkers for cognitive decline and neurodegenerative diseases.  The company has built large databases of EEG data from healthy individuals and those with various neurodegenerative diseases, which allows them to compare a patient's brain activity to healthy controls and track changes over time.   Dan explains, "We're now in year seven of a large longitudinal study where we've identified and extracted these measures of the brain's electrical activity under different conditions that help us differentiate or characterize whether the person has normal cognition or their sleep looks like somebody with normal cognition. Or how the brain responds to certain stimuli and if it looks like somebody with Parkinson's disease or early Alzheimer's disease. We do that both during sleep and during wake."  Chris elaborates, "What differentiates our products is that Dan mentioned that we've received a little over $40 million in funding from NIH, DARPA, and other funding sources. And that has allowed us to create very large databases with tens of thousands of recordings from healthy controls. So people ages 6 to 96. For any new patient that comes in, we can compare their brain to a group of people in the same age range and sex and say, how far are you quantitatively from your healthy control peers?" "We print everything, all of the EEG sensors, on a very lightweight flex cable, which is easily applied and hits all the target sites according to the neurology 10-20 system. That is fully disposable. So after you take it off, you discard it. It's only used once. Then, all of the electronics for our system, which does the amplification of the signals, the digitization of the signals, and then sending via Bluetooth to a laptop or a handheld or desktop computer. All of that is in a very small electronics box worn on the head. The entire system weighs less than three ounces. So we've had patients wear it for many hours and forget they're wearing it. It's so lightweight and comfortable." #AdvancedBrainMonitoring #EEG #NeuroBiomarkers #Cognition #NeuroDiagnosticDevice #AlzheimersDisease #Dementia #ParkinsonsDisease #LewyBodyDementia advancedbrainmonitoring.com Download the transcript here

Dan Levendowski, Co-Founder and President, and Chris Berka, Co-Founder and CEO of Advanced Brain Monitoring, have developed medical devices that measure brain activity through electroencephalography (EEG) during awake and sleeping states. These easy-to-use EEG devices can be used at home and in a clinic to identify biomarkers for cognitive decline and neurodegenerative diseases.  The company has built large databases of EEG data from healthy individuals and those with various neurodegenerative diseases, which allows them to compare a patient's brain activity to healthy controls and track changes over time.   Dan explains, "We're now in year seven of a large longitudinal study where we've identified and extracted these measures of the brain's electrical activity under different conditions that help us differentiate or characterize whether the person has normal cognition or their sleep looks like somebody with normal cognition. Or how the brain responds to certain stimuli and if it looks like somebody with Parkinson's disease or early Alzheimer's disease. We do that both during sleep and during wake."  Chris elaborates, "What differentiates our products is that Dan mentioned that we've received a little over $40 million in funding from NIH, DARPA, and other funding sources. And that has allowed us to create very large databases with tens of thousands of recordings from healthy controls. So people ages 6 to 96. For any new patient that comes in, we can compare their brain to a group of people in the same age range and sex and say, how far are you quantitatively from your healthy control peers?" "We print everything, all of the EEG sensors, on a very lightweight flex cable, which is easily applied and hits all the target sites according to the neurology 10-20 system. That is fully disposable. So after you take it off, you discard it. It's only used once. Then, all of the electronics for our system, which does the amplification of the signals, the digitization of the signals, and then sending via Bluetooth to a laptop or a handheld or desktop computer. All of that is in a very small electronics box worn on the head. The entire system weighs less than three ounces. So we've had patients wear it for many hours and forget they're wearing it. It's so lightweight and comfortable." #AdvancedBrainMonitoring #EEG #NeuroBiomarkers #Cognition #NeuroDiagnosticDevice #AlzheimersDisease #Dementia #ParkinsonsDisease #LewyBodyDementia advancedbrainmonitoring.com Listen to the podcast here

In this thought-provoking episode, we delve into the intricate world of neurodegenerative diseases, unraveling the mysteries of conditions such as Alzheimer's, Parkinson's, and ALS. Check out the preprint on Neurochemistry at ChemRxiv, pending in peer review: Design of Partial Agonists of ADAMTS Metalloproteinases as Therapeutics for Neurodegenerative Diseases | Biological and Medicinal Chemistry | ChemRxiv | Cambridge Open Engage -- Disclaimer: The views of the podcast reflect those of the guests and I. Please note these views and their sentiment do not constitute advice, suggestions or recommendations. Please see the relevant board-certified health professionals.

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Will Microdosing Enhance Your Personal and Professional Growth?   In this episode of the Longevity podcast, I am joined by Paul Austin, a leading expert on microdosing and psychedelics to discuss the world of performance enhancement, neuroplasticity, and how both psilocybin and LSD can play unique roles in personal growth and mental health. We also discuss the broader implications of psychedelic use and the promising research surrounding their therapeutic potential. Paul Austin is a visionary entrepreneur and a leading voice in the realm of psychedelic education and microdosing. As the founder of the educational platform Third Wave, Paul has been dedicated to exploring the burgeoning frontier of psychedelics to enhance cognitive performance, mental health, and overall well-being. Paul continues to push the boundaries of what's possible through mindful and informed psychedelic use and is truly at the forefront of reimagining how we approach mental and emotional wellness in the 21st century.   Thank you to our sponsors for making this episode possible: Manukora: Discover the benefits of premium Manuka honey with Manukora at http://manukora.pxf.io/kO0rJN.  Young Goose: Get 10% off your first order with code NAT10 at https://www.younggoose.com/?sca_ref=4464009.kEvuKfs1CO and save on future orders with code 5NAT at https://www.younggoose.com/?sca_ref=1194545.1x50tznxez. BEAM Minerals: Go to https://www.beamminerals.com code NAT20 to get 20% off your order   Find more from Paul Austin: Website: https://thethirdwave.co/ Facebook: https://www.facebook.com/thirdwaveishere Twitter: https://twitter.com/thirdwaveishere Instagram: https://www.instagram.com/paulaustin3w/?hl=en    Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat's Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance    What We Discuss: 00:24 Paul's Journey to Portugal 03:14 Early Life and First Encounters with Cannabis 04:44 Exploring Psychedelics and Their Impact 07:00 The Birth of Third Wave 10:05 The Resurgence of Psychedelic Research 14:44 Understanding Different Psychedelics 22:02 Microdosing: Benefits and Practices 30:43 Microdosing LSD for Enhanced Focus and Creativity 31:58 Comparing LSD and Psilocybin: Effects and Uses 33:35 Combining Psilocybin with Other Supplements 34:41 The Stamets Stack: A Powerful Combination 38:21 Microdosing Protocols and Personal Experiences 41:45 Psychedelics and Neurodegenerative Diseases 51:51 Microdosing for Chronic Diseases and Mental Health 57:37 Resources and Programs for Psychedelic Coaching Key Takeaways: Microdosing with psychedelics like psilocybin mushrooms and LSD for enhancing neuroplasticity, improving focus, creativity, and emotional well-being. There is anecdotal and emerging research evidence that psychedelics might help with chronic conditions like Lyme disease, long COVID, and mold toxicity Psilocybin is valuable for emotional processing and therapy, while MDMA is on the cusp of FDA approval for treating PTSD

Are you concerned about cognitive decline for yourself or a loved one? Curious what you can do now to prevent neurodegenerative disease? Tune in to hear us discuss neurodegenerative disease, from dementia and Parkinson's, to depression and anxiety and beyond.    In this episode, we discuss the sharp increase in neurodegenerative disease in recent years and the many possible root causes of these conditions. Learn how addressing the gut, inflammation, toxicity, metabolic health and more can prevent disease or improve outcomes. Plus we discuss the most helpful lab and supplement interventions to support optimal brain function.    Also in this episode: Buy 3 Get 1 Free Naturally Nourished Tea with code FREETEA 5 Day Detox PDF Free Keto Reset Live Masterclass 1/15 Save the Date, Class Starts 1/29 Naturally Nourished Gift Cards What is neurodegenerative disease?  The methylation connection Episode 331 Homocysteine and Methylation Methyl Complete Genetic SNP Testing Cardiometabolic Panel Functional approaches to neurodegenerative disease Gut Health GI Map Stool Test MRT Test Probiotic Challenge  Rebuild Spectrum Probiotic Targeted Strength Probiotic GI Lining Support GI Immune Builder KidsBiotic Inflammation Anti-Inflammatory Bundle EPA DHA Liquid EPA DHA Extra Vitamin D Balanced Blend Cellular Antiox Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical Markers Multidefense Dry Farm Wines use code ALIMILLERRD Toxicity Episode 364 EMF and Cell Phone Radiation 10 Day Detox Micronutrient Panel Antioxidant status Cellular Antiox Grassfed Whey Alpha Lipoic Acid CoQ10 Metabolic Health  Keto and neuroplasticity Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms Effects of intermittent fasting on brain metabolism Intermittent metabolic switching, neuroplasticity, and brain health Intermittent fasting and metabolic switching: a brief overview. Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases Stress Relax and Regulate Calm and Clear GabaCalm Episode 322 Nature as Medicine 4-7-8 Breath Neurohormone Lab Labs Homocysteine

Only about a decade ago did scientists discover the immense potential of leveraging the immune system to combat neurodegenerative diseases. Professor of Neuroscience John Lukens played an integral part in that movement, and he continues to push the field forward today as the inaugural director of UVA's Harrison Family Translational Research Center in Alzheimer's and Neurodegenerative Diseases.

Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges in bringing their nanomedicine to market. 

 Last month, the NIH announced that it had found evidence of research misconduct by Eliezer Masliah, M.D., the head of the neuroscience division at the National Institute on Aging. The NIH announcement coincided with the Sept. 26 publication of an investigation by Science, finding that 132 papers published by Masliah appear to contain manipulated images.  In this week's episode of “The Top Line,” Fierce Biotech's Darren Incorvaia dives into this issue with Matthew Schrag, M.D., Ph.D., a neuroscientist who contributed to the dossier outlining Masliah's misconduct. To learn more about the topics in this episode:   NIH neuroscience leader committed research misconduct, agency investigation findsSee omnystudio.com/listener for privacy information.

Choosing the right supplements for you can be challenging - and sometimes expensive. But some supplements pack more punch per dollar than others! Jared's mission is always to teach you to master natural supplements and part of that is knowing where you can get the most bang for your buck. On this episode of Vitality Radio, Jared begins a new series where he shares three supplements that cost less than 50 cents a day but are incredibly effective for some of the biggest health concerns people have. You'll learn about creatine, selenium, and chromium, and their benefits for muscle health, prevention of neurodegenerative disease, cardiovascular health, cancer prevention, hormone balance, insulin resistance, and overall metabolic health, so that you can decide if these affordable supplements are right for you and your budget.Products:NutraBio Creatine MonohydrateSunwarrior Active CreatineNatural Factors SelenoExcell SeleniumVital 5 Ultimate Vitality MultiNatural Factors Chromium GTFAdditional Information:#408: Creatine for More Than Muscle - Mitochondria, Brain, Heart, Gut, Skin Health, and More!#347: Thyroid Health: Why Your Doctor Might Be Looking at the Wrong Numbers With Dr. Todd CameronVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Stephanie Venn-Watson, a marine biologist, discusses her research on dolphins and the discovery of Fatty15, a 15-carbon saturated fat that plays a crucial role in cellular health and longevity. The research in dolphins has implications for human health and longevity. The conversation explores the role of fatty acid C:15 in various health conditions, including liver damage, neurodegenerative diseases, anemia, and cardiovascular health. The researchers discuss how C:15 deficiency can lead to iron overload in the liver, causing lipid peroxidation and insulin resistance. They also highlight the potential benefits of C:15 in improving brain health, reducing neuroinflammation, and supporting the immune system. The conversation concludes with a discussion on ongoing research projects and the potential applications of C:15 in various health conditions.  For the audience  * Use code GLADDEN for 15% OFF your Fatty15 at fatty15.com/GLADDEN  * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/      Takeaways    * Dolphins with higher levels of C:15, a 15-carbon saturated fat, have slower aging rates and better overall health.  * C:15 protects cell membranes from lipid peroxidation and improves cellular signaling and energy production.  * C:15 inhibits JAK-STAT, reducing inflammation and cancer cell proliferation.  * Higher levels of C:15 are associated with a lower risk of cardiovascular disease.  * Supplementing with C:15 can attenuate the symptoms of liver damage and non-alcoholic fatty liver disease.  * C:15 may have potential benefits in improving brain health and reducing neuroinflammation.  * C:15 supplementation may help improve cardiovascular capacity and support the immune system.  * Ongoing research is exploring the effects of C:15 on anemia and Alzheimer's disease.    Chapters    00:00 Dosing and Linear Dose Response of Fatty15  23:06 Exploring the Impact of C:15 on Liver Health and Metabolic Syndrome  24:59 C:15's Role in Addressing Neurodegenerative Diseases and Cognitive Improvement  28:01 The Link Between C:15 and Cardiovascular Capacity, Anemia, and Immune System Function  32:42 C:15- Cellular Health, Longevity, and Well-being  46:02 Goodbye    To learn more about Fatty15:  * Websites: www.DiscoverC15.com   * www.fatty15.com   * Instagram: (@fatty15) https://www.instagram.com/fatty15/      Reach out to us!  Website: https://gladdenlongevity.com/   Email: podcast@gladdenlongevity.com   Facebook: https://www.facebook.com/Gladdenlongevity/  Instagram: https://www.instagram.com/gladdenlongevity/?hl=en   LinkedIn: https://www.linkedin.com/company/gladdenlongevity  YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw  

Welcome back to UNBIASED. In today's episode we're talking about GOOD NEWS that has NOTHING to do with the election: Just a *FEW* Election Notes, Nothing Serious (0:07) Trick-or-Treaters Give Back on Halloween (2:48) New Brain Study Shows Impact of Physical Activity on Neurodegenerative Diseases (5:45) Woman Who Received Double Lung Transplant Marries Donor's Brother (8:48) Scientists Create Suit to Help People Move Better (10:01) I Asked YOU to Share Good Things That Have Happened to You Recently and Here's What You Said (10:57) Quick Hitters: Boeing Workers Vote to End Strike, Meta Halts Possible AI Data Center Plans Over Bee Species, Supreme Court to Hear Louisiana Congressional Districting Case (15:45) Listen/Watch this episode AD-FREE on Patreon. Watch this episode on YouTube. Follow Jordan on Instagram and TikTok. All sources for this episode can be found here.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Nearly one million people in the U.S. are living with Parkinson's disease, a condition for which there is still no known cause or cure. Joseph Mazzulli, PhD, has led two recent studies published in Neuron and Nature Communications uncovering previously unknown cellular mechanisms driving the disease. These studies highlight the potential for new therapeutic targets, including restoring neuronal function for patients with Parkinson's and other neurodegenerative diseases.   

Today we have Dr. Rudolph E. Tanzi, who is perhaps best known for co-discovering all three familial early-onset Alzheimer's disease genes. In addition, Rudy's lab was the first to use human stem cells to create three-dimensional human brain organoids and three-dimensional neural-glial culture models of Alzheimer's disease, which became known as “Alzheimer's-in-a-Dish.” These models were the first to recapitulate all three of the key pathological hallmarks of Alzheimer's disease and have made drug screenings faster and cheaper. Rudy is the director of the Genetics and Aging Research Unit as well as the director of the Henry and Allison McCance Center for Brain Health. Rudy is also co-Director of the Massachusetts General Institute for Neurodegenerative Disease at Massachusetts General Hospital and serves as the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Rudy has published more than 700 research papers and is one of the top 50 most cited neuroscientists in the world. He is author of “Decoding Darkness,” and a co-author of two books with Deepak Chopra, “Super Brain” and “The Healing Self.” Show notes: [00:03:18] Ken opens the interview mentioning that Rudy began playing the accordion when he was just seven years old. Ken goes on to ask Rudy about the time his father gave him a Jimmy Smith album and some advice. [00:05:51] Ken mentions that, in addition to Rudy's musical talents, he was also interested in science growing up. Ken asks about Rudy's participation in the Westinghouse Science Talent Search and what that experience was like. [00:07:09] Ken asks Rudy about growing up in Cranston, Road Island. [00:08:39] Rudy talks about how he ended up at the University of Rochester after high school. [00:09:51] Ken mentions that both Rudy's grandfather and father passed away at the age of 45. Ken asks Rudy if this played a role in his pursuit of a career in genetics research. [00:10:57] Rudy explains how he chose Harvard Medical School for his Ph.D. [00:12:47] Ken pivots to ask Rudy about his time working with Jim Gusella in the early 80's at Mass General, where they were the first to ever find a disease gene. Family studies at the time had shown that the Huntington's disease gene was linked to a polymorphic DNA marker. Rudy talks about this discovery and how the chromosomal localization of the Huntington's disease gene was the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder. [00:16:07] Ken asks Rudy about his work in 1987, when he discovered the first Alzheimer's gene, recombinant DNA technology, which causes the production of amyloid. Ken goes on to explain that mutations in the APP gene can cause a rare form of early onset Alzheimer's. Rudy talks about the paper that came out in “Science” that detailed this discovery. [00:18:38] Rudy discusses his personal philosophy and approach to research. [00:19:43] Ken mentions that in Rudy's book, Decoding Darkness, he writes that few nightmares on Earth can compare to Alzheimer's disease. Ken asks Rudy to talk more about this book. [00:21:50] Ken explains that in the same way our physical capabilities will suffer some form of decline with age, it is also expected that we have some decline in memory and cognitive ability as we age as well. However, Ken goes on to say that when people begin to experience age-related memory lapses, it can lead to a lot of anxiety about their genetic predisposition to Alzheimer's. Ken asks Rudy to talk about the lifestyle factors that play into whether someone predisposed to develop Alzheimer's can stave off or avoid disease development. [00:26:09] Ken explains that aging appears to intensify when people stop challenging themselves with new things. Given this, Ken asks Rudy what his thoughts are on challenging our brains as they age to protect our cognitive abilities. [00:29:08] Ken asks Rudy about the principal advances in...

Lou Reese, Executive Chairman of Vaxxinity, shares his journey from real estate to biotech, discussing groundbreaking advances in Alzheimer's and Parkinson's treatment. Discover how Reese's mission to democratize health is reshaping the future of medicine and potentially impacting millions of lives worldwide Learn more about your ad choices. Visit megaphone.fm/adchoices

On this week's episode of the Balancing Chaos Podcast, Kelley sits down with certified brain-health coach Kayla Barnes to discuss all things biohacking, brain health and how we can live as long and as well as possible. Kayla is an entrepreneur and biohacker with a mission to help her clients and community achieve optimal health through science and research-backed approaches. Kayla has been named one of the top longevity leaders globally and has been featured in Forbes, Thrive Global, Byrdie and more. Barnes has a background in nutrition, has trained under the renowned brain doctor, Dr. Daniel Amen, and is the owner of the wellness space LYV. Through their conversation, Kelley and Kayla dive into the latest science-backed wellness tools to elevate cognitive function and eliminate brain fog. By understanding the way hormones and gut health play a role in brain health, we can optimize the way we think and feel by harnessing the power of those connections. From what testing you should be doing on your gut, hormones and brain to the best diet for brain health and how to lower your toxic burden and which biohacking tools are actually worth the money and time, we go over everything you've ever wanted to know about brain health, mood, and mental health.To connect with Kelley click HERETo book a lab review click HERETo connect with Kayla click HERE

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter provides a comprehensive introduction to longevity, perfect for newcomers or those looking to refresh their knowledge. He lays out the foundational concepts of lifespan, healthspan, and the marginal decade. Additionally, Peter discusses the four main causes of death and their prevention, as well as detailing the five key strategies in his longevity toolkit to improve lifespan and healthspan. Detailed show notes provide links for deeper exploration of these topics, making it an ideal starting point for anyone interested in understanding and improving their longevity. We discuss: Key points about starting exercise as an older adult [2:45]; Overview of episode topics and structure [1:45]; How Peter defines longevity [3:45]; Why healthspan is a crucial component of longevity [11:15]; The evolution of medicine from medicine 1.0 to 2.0, and the emergence of medicine 3.0 [15:30]; Overview of atherosclerotic diseases: the 3 pathways of ASCVD, preventative measures, and the impact of metabolic health [26:00]; Cancer: genetic and environmental factors, treatment options, and the importance of early and aggressive screening [33:15]; Neurodegenerative diseases: causes, prevention, and the role of genetics and metabolic health [39:30]; The spectrum of metabolic diseases [43:15]; Why it's never too late to start thinking about longevity [44:15]; The 5 components of the longevity toolkit [46:30]; Peter's framework for exercise—The Centenarian Decathlon [47:45]; Peter's nutritional framework: energy balance, protein intake, and more [58:45]; Sleep: the vital role of sleep in longevity, and how to improve sleep habits [1:08:30]; Drugs and supplements: Peter's framework for thinking about drugs and supplements as tools for enhancing longevity [1:13:30]; Why emotional health is a key component of longevity [1:17:00]; Advice for newcomers on where to start on their longevity journey [1:19:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube