Podcasts about Medicine

Science and practice of the diagnosis, treatment, and prevention of physical and mental illnesses

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    Latest podcast episodes about Medicine

    Engines of Our Ingenuity
    The Engines of Our Ingenuity 1516: Saving the Lore

    Engines of Our Ingenuity

    Play Episode Listen Later Jan 30, 2026 3:39


    Episode: 1516 In which we must save the lore as well as the plants.  Today, we have to save more than the endangered plants.

    Pediheart: Pediatric Cardiology Today
    Pediheart Podcast #370: Fetal Intervention For Restrictive Or Intact Atrial Septum In HLHS

    Pediheart: Pediatric Cardiology Today

    Play Episode Listen Later Jan 30, 2026 37:13 Transcription Available


    This week we review a recent work on fetal atrial septal interventions in the patient with hypoplastic left ventricle or double outlet right ventricle with mitral valve atresia/dysplasia and a restrictive or intact atrial septum. How often was this procedure technically feasible and successful? What are the criteria to be considered for such an intervention? Why does use of a laser improve the crossing of the atrial septum in this procedure? Should prenatal intervention be used instead of postnatal intervention in this setting? Associate Professor of Pediatrics at Baylor College of Medicine, Dr. Betul Yilmaz shares her insights into this fascinating topic.https://doi.org/10.1161/CIRCINTERVENTIONS.125.015209

    Intelligent Medicine
    Leyla Weighs In: Weight Loss Without Muscle Loss--A Look into Krill Oil Benefits

    Intelligent Medicine

    Play Episode Listen Later Jan 30, 2026 25:17


    Nutritionist Leyla Muedin discusses the importance of maintaining muscle mass during weight loss, highlighting recent research on the benefits of krill oil. Leyla delves into various aspects of the study conducted by Glasgow University's School of Human Nutrition, which demonstrated that daily supplementation with krill oil helps minimize muscle loss despite significant weight loss. The episode covers study details, the impact of krill oil on inflammation, muscle maintenance, and the potential advantages of krill oil over traditional fish oil. Leyla also emphasizes the critical role of a balanced diet and strength training in preserving muscle mass during weight loss journeys.

    Faculty Factory
    YouTube as a Platform for Inspiring Faculty with Jessica Seaman, EdD

    Faculty Factory

    Play Episode Listen Later Jan 30, 2026 36:22


    Jessica Seaman, EdD, has learned many tips and tricks while building a library of recordings and a repository of resources on YouTube to assist learners. She joins the Faculty Factory Podcast this week for an inspiring exploration of that process. As a self-taught YouTube practitioner and editor with no prior experience, Dr. Seaman is proof that anyone can learn this tool and leverage it to reach and help faculty worldwide. Dr. Seaman is an Assistant Professor of Medical Humanities and Assistant Dean of Faculty Development at Creighton University School of Medicine in Phoenix, Ariz. This is her second appearance on the Faculty Factory. If you would like to revisit her first appearance on the program—the episode titled "Best Supporting Practices and Strategies for Stressed-Out Learners and Faculty"—you can see it here: https://facultyfactory.org/jessica-seaman/ You can also visit the Creighton University Health Sciences YouTube channel featuring free faculty development videos here: https://www.youtube.com/playlist?list=PLoeK9S4P4sSeSp338JTW2ro7vHYfKycRc If you'd like to ask questions to her directly, please email Dr. Seaman at: jessicaseaman@creighton.edu Faculty Development Resource Spotlight Many faculty development departments are doing groundbreaking work, and not just for their own faculty. Many institutions offer publicly accessible, free resources that anyone can explore and use, such as the CU Health Sciences YouTube channel. Furthermore, if you haven't already done so, we urge you to visit the newest addition to our website: the Faculty Development Resource Spotlight webpage: https://facultyfactory.org/resource-spotlight/ -- with other great faculty development and leadership resources! We'd love for it to grow into a centralized repository for faculty. Please reach out to us here to learn more or suggest a resource for us to add!

    OncLive® On Air
    S15 Ep41: Multidisciplinary Breast Cancer Experts Outline Proactive Strategies for Managing Treatment-Related Toxicities: With Neil Iyengar, MD; Heather Moore, CPP, PharmD; and Sarah Donahue, MPH, NP

    OncLive® On Air

    Play Episode Listen Later Jan 30, 2026 42:39


    In today's episode, Neil Iyengar, MD, moderated an OncLive Insights discussion about adverse effect management when using breast cancer therapies targeting the PI3K, AKT, and mTOR pathways. Dr Iyengar is an associate professor in the Department of Hematology and Medical Oncology and co-director of Breast Medical Oncology in the Department of Hematology and Medical Oncology at Emory University School of Medicine; as well as director of Survivorship Services at the Winship Cancer Institute of Emory University in Atlanta, Georgia. He was joined by Heather Moore, CPP, PharmD, a clinical pharmacist practitioner at the Duke Cancer Center Breast Clinic in Durham, North Carolina; and Sarah Donahue, MPH, NP, a nurse practitioner at the University of California San Francisco Health.  In our exclusive discussion, the experts highlighted the importance of early and comprehensive testing (using both tissue and liquid biopsies) for genetic alterations to guide treatment decisions. They also noted strategies for managing diarrhea, including patient education on diet, proactive use of loperamide, and regular monitoring. They also explained that hyperglycemia management should hinge on prophylactic use of metformin or SGLT2 inhibitors, dietary restrictions, and frequent glucose monitoring. Their conversation on rash management included insights about prophylactic antihistamines, patient education on skin care, and involving dermatology for severe cases. Overall, the experts spotlighted the importance of multidisciplinary collaboration and proactive patient education when treating patients with breast cancer.

    Something Was Wrong
    S25 Ep5: Testing Me

    Something Was Wrong

    Play Episode Listen Later Jan 29, 2026 51:07


    *Content Warning: grooming, institutional betrayal, sexual violence, stalking, on-campus violence, intimate partner violence, gender-based violence, stalking, rape, and sexual assault.Free + Confidential Resources + Safety Tips: somethingwaswrong.com/resources   SWW Sticker Shop!: https://brokencyclemedia.com/sticker-shop SWW S25 Theme Song & Artwork: The S25 cover art is by the Amazing Sara Stewart instagram.com/okaynotgreat/ The S25 theme song is a cover of Glad Rag's U Think U from their album Wonder Under, performed by the incredible Abayomi instagram.com/Abayomithesinger. The S25 theme song cover was produced by Janice “JP” Pacheco instagram.com/jtooswavy/ at The Grill Studios in Emeryville, CA instagram.com/thegrillstudios/ Follow Something Was Wrong: Website: somethingwaswrong.com  IG: instagram.com/somethingwaswrongpodcast TikTok: tiktok.com/@somethingwaswrongpodcast  Follow Tiffany Reese: Website: tiffanyreese.me  IG: instagram.com/lookieboo Sources:Association of American Universities. Campus Climate Survey on Sexual Assault and Sexual Misconduct. Westat / Cantor et al., 2015 and 2017.Holland, Kathryn J., Cortina, Lilia M., and Freyd, Jennifer J. Research on institutional betrayal and sexual violence in higher education, 2018–2021. Miodus, Stephanie, et al. “Campus Sexual Assault: Fact Sheet from an Intersectional Lens.” American Psychological Association, American Psychological Association, www.apa.org/apags/resources/campus-sexual-assault-fact-sheetNational Academies of Sciences, Engineering, and Medicine. Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine. National Academies Press, 2018.Sable, Marjorie R., et al.; Cantor, David, et al. Multi-campus climate survey analyses examining reporting behavior and trust in institutions.U.S. Department of Justice, Bureau of Justice Statistics. National Crime Victimization Survey special analyses on reporting disparities.Wood, Leila et al. “Sexual Harassment at Institutions of Higher Education: Prevalence, Risk, and Extent.” Journal of interpersonal violence vol. 36,9-10 (2021): 4520-4544. doi:10.1177/0886260518791228

    The Brian Lehrer Show
    How AI is Changing Medicine

    The Brian Lehrer Show

    Play Episode Listen Later Jan 29, 2026 30:01


    Lloyd Minor, M.D., dean of Stanford University School of Medicine and VP of medical affairs at Stanford University, talks about the big changes artificial intelligence is bringing to research and health care, especially related to cancer and chronic diseases, and shares how Stanford is training physicians to use AI.

    The FOX News Rundown
    Corporate Takeover of Healthcare and the "Destruction of Medicine"

    The FOX News Rundown

    Play Episode Listen Later Jan 29, 2026 30:30


    Independent medical practice is under siege, according to Rep. Greg Murphy (R-NC). Murphy, a practicing physician for over 30 years, joins the Rundown to discuss the "explosion" of insurance claim denials and the "destruction of medicine" caused by what he calls vertical integration and the corporate takeover of healthcare. He breaks down the GOP's plan to restore marketplace competition, the debate over Affordable Care Act (ACA) subsidies, and why he believes the current system prioritizes corporate profit over medical necessity. TikTok is set to remain in the U.S. following a deal granting American entities majority ownership, ending the immediate threat of a nationwide ban. But does this restructuring resolve concerns over data privacy and the safety of young users? Cybersecurity expert John Cofrancesco joins to discuss whether the deal addresses the national security risks that sparked the ban, the legal battles over social media addiction, and the race to outpace China in artificial intelligence. Plus, commentary by FOX News contributor Tom Shillue. Learn more about your ad choices. Visit podcastchoices.com/adchoices

    Fulfilled as a Mom
    361: [WORK] 13 Years In – What Medicine Has Taught Me (The Honest Version)

    Fulfilled as a Mom

    Play Episode Listen Later Jan 29, 2026 13:19


    After 13 years of practicing medicine, I'm not here to pretend I have it all figured out. I am here to share what experience has quietly, steadily taught me.In this episode, I'm reflecting on 13 lessons I've learned in my 13 years as a PA—from why people and schedules matter more than specialty, to how burnout isn't something you beat but something you learn to monitor, to why there is absolutely no award for doing it the hard way.This isn't a how-to episode or a deep clinical dive. It's an honest, human reflection on what it takes to build a career in medicine that actually lasts. Consider this an invitation to pause, reflect, and ask yourself: what have I learned in my own years of practice?Inside this episode, we talk about:Why culture, autonomy, and respect matter more than we're taughtHow your real legacy lives outside the hospital or clinicWhy medicine is an Ironman, not a sprintBurnout as a chronic condition—not a personal failureThe power of mentorship, sponsorship, and turning around to help othersNegotiation as a skill we were never taught—but desperately needWhy part-time practice still countsAnd the truth about martyrdom (spoiler: there's no prize)Reflection isn't indulgent. It's how we make this work sustainable—for ourselves and for the clinicians coming behind us.SPONSORS:ADVANCED PRACTICE PLANNING, LLC: advancedpracticeplanning.com/fiSERMO https://app.sermo.com:443/?sermoref=39d97a2c-f699-4f8b-b2f9-1eb131e18c75&utm_campaign=tell-a-friend CONNECT ⁠FREE 30-MINUTE COACHING CONSULT⁠ ⁠⁠https://calendly.com/the-pa-is-in/gen-call⁠ ⁠ ⁠1-ON-1 NEGOTIATION CONSULT ⁠https://calendly.com/the-pa-is-in/negotiate⁠⁠CONNECT WITH TRACY

    The Short Coat
    The Surprising Connection Between Hobbies and Medicine

    The Short Coat

    Play Episode Listen Later Jan 29, 2026 66:22


    Don’t give up the outside activities that’ll make you a better doc As Dave has observed many times, medicine will take everything you have, if you allow it to. What this means is that you have to carve out time for your own interests, whether you’re a physician or a medical student. These are the things that not only keep you sane–an outlet for all the intensity that the study and practice of medicine has to offer–but they can even make you better at surgery or how positively your patients view you. M1s Ben Cooper, Reese Rosenmeyer, Arielle Weber, and Reed Adajaar talk about their hobbies, what they get out of them as hard-working medical students, where they prioritize them in their lives, and why it’s sometimes even easier to enjoy them in med school than it was as undergrads. Dave offers some findings on how having outside interests makes doctors great. And the crew answers a question from Nicole, a mother of three little ones and military wife who, at the ripe old age of 35, is contemplating how she can pursue her lifelong dream of becoming a doctor. If you have a question we can discuss on the show, send it in at https://theshortcoat.com/tellus! Episode credits: Producer: Anna Royer Co-hosts: Ben Cooper, Reed Adajaar, Reese Rosenmeyer, Arielle Weber The views and opinions expressed on this podcast belong solely to the individuals who share them. They do not represent the positions of the University of Iowa, the Carver College of Medicine, or the State of Iowa. All discussions are intended for entertainment purposes only and should not be taken as professional, legal, financial, or medical advice. Nothing said on this podcast should be used to diagnose, treat, or prevent any medical condition. Always seek qualified professional guidance for personal decisions. We Want to Hear From You: YOUR VOICE MATTERS! We welcome your feedback, listener questions, and shower thoughts. Do you agree or disagree with something we said today? Did you hear something really helpful? Can we answer a question for you? Are we delivering a podcast you want to keep listening to? Let us know at https://theshortcoat.com/tellus and we'll put your message in a future episode. Or email theshortcoats@gmail.com. We need to know more about you! https://surveys.blubrry.com/theshortcoat (email a screenshot of the confirmation screen to theshortcoats@gmail.com with your mailing address and Dave will mail you a thank you package!) The Short Coat Podcast is FeedSpot’s Top Iowa Student Podcast, and its Top Iowa Medical Podcast! Thanks for listening! We do more things on… Instagram: https://www.instagram.com/theshortcoat YouTube: https://www.youtube.com/theshortcoat You deserve to be happy and healthy. If you’re struggling with racism, harassment, hate, your mental health, or some other crisis, visit http://theshortcoat.com/help, and send additions to the resources there to theshortcoats@gmail.com. We love you.

    Intelligent Medicine
    Q&A with Leyla, Part 2: Low Fat v. Full Fat Dairy

    Intelligent Medicine

    Play Episode Listen Later Jan 29, 2026 37:52


    Anecdote on Heart Rate VariabilityWill there soon be biological criteria for diagnosing clinical depression?What is your opinion on cardioversion for curing atrial fibrillation?What's with the ongoing battle between low fat and full fat dairy advocates?What is the optimal blood level of folate?

    Intelligent Medicine
    Q&A with Leyla, Part 1: Leg Cramps

    Intelligent Medicine

    Play Episode Listen Later Jan 29, 2026 39:39


    Fish oil linked to reduced risk of atrial fibrillationIs it safe to take hydrogen peroxide every day over the long term?I've been experiencing arthritis and leg cramps during the night. What should I take?I follow a low-carb diet. Why is my Hemoglobin A1c high?

    Epigenetics Podcast
    Taking ChIP from Yeast to ENCODE to Enable Genome-Wide Regulatory Protein Mapping (Peggy Farnham)

    Epigenetics Podcast

    Play Episode Listen Later Jan 29, 2026 29:56


    In this episode of the Epigenetics Podcast, we talked with Peggy Farnham from the Keck School of Medicine at USC about her work on establishing the ChIP Method in mammalian cells. In this episode, we dive into the relationship between transcription factors, chromatin dynamics, and gene expression with Professor Peggy Farnham from the Keck School of Medicine at USC. Professor Farnham shares her profound insights into how her groundbreaking research has reshaped our understanding of gene regulation and its implications in cancer. We explore how she has been a pioneer in mapping the genome-wide landscape of regulatory proteins, illuminating the molecular logic behind transcriptional control and its disruption in cancer biology. The interview starts with her instrumental role in adapting chromatin immunoprecipitation (ChIP) technology from yeast to human cells. Professor Farnham reflects on the technical challenges she faced during this transition, such as the quest for visibility of signals in mammalian systems. Her ability to innovate and troubleshoot challenges led to significant advancements in techniques that allow for the rapid identification of transcription factor binding sites, fundamentally changing the landscape of epigenetic research. As the discussion progresses, we learn about Professor Farnham's active involvement in the ENCODE project, where she contributed to high-resolution mapping of transcription factors and regulatory elements in human cells. She articulates her appreciation for collaborative efforts in science, highlighting how working within a consortium harnesses the collective expertise of diverse research groups. This collaboration not only bolstered the credibility of the data produced but also propelled the field forward in understanding the complexity of gene regulation. Through her participation in various projects, such as the Psyc-ENCODE consortium and the Roadmap Epigenome Mapping Consortium, Professor Farnham shares insights into her investigation of epigenetic variations, particularly in relation to complex disorders like schizophrenia. Her findings underscore the nuances of enhancer variability among individuals and the implications for understanding disease mechanisms, thereby advancing our knowledge of genetic regulation and its contributions to diverse biological outcomes. Moreover, the episode highlights Professor Farnham's reflective understanding of emerging technologies in the field. She discusses the evolution of methods that allow researchers to investigate gene regulation at single-cell resolution, recognizing the significant implications these innovations have for our comprehension of cellular differentiation and the transcriptional landscape. References Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Molecular and Cellular Biology. 2001 Oct;21(20):6820-6832. DOI: 10.1128/mcb.21.20.6820-6832.2001. PMID: 11564866; PMCID: PMC99859. Wells J, Farnham PJ. Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods (San Diego, Calif.). 2002 Jan;26(1):48-56. DOI: 10.1016/s1046-2023(02)00007-5. PMID: 12054904. Rhie SK, Schreiner S, Witt H, et al. Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation. Science Advances. 2018 Dec;4(12):eaav8550. DOI: 10.1126/sciadv.aav8550. PMID: 30555922; PMCID: PMC6292713. Tak YG, Hung Y, Yao L, et al. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Research. 2016 May;44(9):4123-4133. DOI: 10.1093/nar/gkv1530. PMID: 26743005; PMCID: PMC4872074. Related Episodes The Effect of lncRNAs on Chromatin and Gene Regulation (John Rinn) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) The Future of Protein–DNA Mapping (Mitch Guttman) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

    My Veterinary Life
    Be Kind and Be Brave with Drs. Kristin Jankowski and Sheena Warman

    My Veterinary Life

    Play Episode Listen Later Jan 29, 2026 29:17


    Dr. Kristin Jankowski, Director of Veterinary Services at Open Door Veterinary Collective, and Dr. Sheena Warman, Professor of Veterinary Education and Deputy Head of Bristol Veterinary School, explore spectrum of care (also known as contextualized care) on the podcast this week. They discuss how it helps veterinarians deliver compassionate, evidence-based medicine that fits the lives of pets and their families. Drawing on perspectives from the U.S. and U.K., our conversation highlights mindset shifts, education, mentorship, and practical case examples that support access to care and professional wellbeing. We can't wait to share their insights with you!Thank you to our podcast partner Hill's Pet Nutrition! You can find more information about Hill's Pet Nutrition at Hill's Pet Nutrition - Dog & Cat Food Transforming Lives and Hill's Vet - Veterinary Health Research, Practice Management Resources.Remember, we want to hear from you! Please be sure to subscribe to our feed on Apple Podcasts and leave us a rating and review. You can also contact us at MVLpodcast@avma.org.Follow us on social media @AVMAVets #MyVetLife #MVLPodcast

    Spotlight on France
    Podcast: Drug prices, Dry January, nuclear tests in French Polynesia

    Spotlight on France

    Play Episode Listen Later Jan 29, 2026 34:58


    How France negotiates drug prices and the impact of US President Donald Trump's pressure to raise them. The Paris bar celebrating sobriety as more people embrace Dry January. And the radioactive legacy of nuclear testing in French Polynesia. Saying he wants to lower the price of medication in the United States, President Donald Trump has been putting pressure on French President Emmanuel Macron to raise the cost of an unspecified pill in France. But it's the French public health system, not Macron, that negotiates with drug companies – keeping prices for patients in check. Sociologist Theo Bourgeron believes that Trump's demand is not about improving care, but pressuring countries to weaken price controls and boost US pharmaceutical profits. (Listen @0') More than a third of the French claim they're not drinking this month to mark Dry January. It's part of a wider trend of falling alcohol consumption in France, particularly among young adults. But in a country famed for its wine and apéro culture, sobriety can be seen as irritating and "un-French". We visit Le Social Bar in Paris, which has gone alcohol-free for January to show you don't need to be tipsy to have a good time. Author Claire Touzard talks about her journey towards sobriety and why alcohol, far from encouraging conviviality, can end up excluding people. And journalist Vincent Edin argues that while France is becoming slightly more tolerant of non-drinkers, successive governments still struggle to recognise that alcoholism is a problem. (Listen @20'15'') France conducted its final nuclear test on 27 January 1996, ending a programme that has left a lasting legacy of health problems in French Polynesia, the archipelago in the South Pacific that for 30 years was France's nuclear testing ground. Hinamoeura Morgant-Cross, a member of the French Polynesian parliament, says the consequences of the testing have been "really traumatic for our people". (Listen @13'50'') Episode mixed by Cecile Pompeani. Spotlight on France is a podcast from Radio France International. Find us on rfienglish.com, Apple podcasts (link here), Spotify (link here) or your favourite podcast app (pod.link/1573769878).

    With Good Reason
    Staggered by the Fact of You

    With Good Reason

    Play Episode Listen Later Jan 29, 2026 51:58


    Join us as we bring two nationally renowned Black poets conversation with a new generation of Black poets. This episode features former Virginia Poet Laureate and Old Dominion University poetry professor Tim Seibles talking with rising poetry star Ariana Benson about alien life, good grammar, and the dreams of Langston Hughes.  Later in the show: Poets Elizabeth Alexander and Nicole Sealey discuss the treasures of archives, the work of a generation, and the resonant truth you feel in your bones. Former Yale professor Elizabeth Alexander is President of the Mellon Foundation and the author of the New York Times best selling memoir, The Light of the World. Alexander and Tim Seibles are Furious Flower Poetry Lifetime Achievement honorees.

    OncLive® On Air
    S15 Ep39: Novel Targeted Agents Are Poised to Influence MPN Treatment Paradigm: With John O. Mascarenhas, MD

    OncLive® On Air

    Play Episode Listen Later Jan 29, 2026 13:46


    Welcome to OncLive On Air®! OncLive On Air is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.In today's episode, we welcomed John O. Mascarenhas, MD, a member of The Tisch Cancer Institute, a professor of medicine at the Icahn School of Medicine, and director of the Center of Excellence for Blood Cancers and Myeloid Disorders at Mount Sinai in New York, New York.In the exclusive interview, Dr Mascarenhas explored novel targeted therapeutic approaches being evaluated in patients with myeloproliferative neoplasms, including myelofibrosis and polycythemia vera. He outlined key reasons for investigating non–JAK inhibitor agents within this treatment paradigm; outlined data from a pair of phase 1 trials (NCT05936359; NCT06034002) evaluating the INCA033989 as monotherapy or in combination with ruxolitinib (Jakafi) in patients with CALR exon 9–mutated myelofibrosis; detailed another ongoing phase 1 study (NCT06313593) looking at INCB160058 in patients with MPNs; and explained how investigational targeted therapies could ultimately impact the MPN treatment paradigm.

    OncLive® On Air
    S15 Ep40: ELEGANT Trial Seeks to Expand Treatment Options for ER+, HER2-Negative Early Breast Cancer: With Aditya Bardia, MD, MPH, FASCO

    OncLive® On Air

    Play Episode Listen Later Jan 29, 2026 5:51


    In today's episode, the discussion features Aditya Bardia, MD, MPH, FASCO. Dr Bardia is a professor in the Department of Medicine in the Division of Hematology/Oncology, the director of Translational Research Integration, and a member of Signal Transduction and Therapeutics at the UCLA Health Jonsson Comprehensive Cancer Center in Los Angeles, California.In the exclusive interview, Dr Bardia discussed the rationale and design of the phase 3 ELEGANT study (NCT06492616), which is evaluating elacestrant (Orserdu) compared with standard endocrine therapy in patients with estrogen receptor–positive, HER2-negative early breast cancer at high risk of disease recurrence.

    RARECast
    Resetting Aberrant Tregs Epigenetically to Treat Autoimmune Diseases

    RARECast

    Play Episode Listen Later Jan 29, 2026 30:19


    Shimon Sakaguchi shared the 2025 Nobel Prize in Physiology or Medicine for his identification of regulatory T cells that suppress autoimmune responses. His work laid the foundation for RegCell, a company he co-founded to develop cell therapies that provide targeted treatments for autoimmune disease without compromising healthy immune function. RegCell epigenetically reprograms patient T cells into regulatory T cells. We spoke to Michael McCullar, CEO of RegCell, about the role of dysfunctional Tregs in autoimmune diseases, the firm's use of epigenetically modified regulatory T cells to treat these conditions, and how this approach can selectively suppress harmful immune responses without causing broad immunosuppression.

    Research Ethics Reimagined
    Ethical Challenges in Suicide Research With Matthew Nock, PhD

    Research Ethics Reimagined

    Play Episode Listen Later Jan 29, 2026 47:08 Transcription Available


    In this episode of PRIM&R's podcast, "Research Ethics Reimagined," we explore the ethical and methodological complexities of suicide and self-harm research with Matthew Nock, PhD, the Edgar Pierce Professor of Psychology at Harvard University and former chair of the Harvard IRB. Dr. Nock discusses how research demonstrates that asking about suicide does not increase risk, the importance of IRB-researcher collaboration, and the challenges of real-time monitoring and intervention with high-risk participants. He shares insights from developing consensus guidelines on ethical conduct of suicide research and emphasizes the critical need for advancing this often-stigmatized field of study.

    From Washington – FOX News Radio
    Corporate Takeover of Healthcare and the "Destruction of Medicine"

    From Washington – FOX News Radio

    Play Episode Listen Later Jan 29, 2026 30:30


    Independent medical practice is under siege, according to Rep. Greg Murphy (R-NC). Murphy, a practicing physician for over 30 years, joins the Rundown to discuss the "explosion" of insurance claim denials and the "destruction of medicine" caused by what he calls vertical integration and the corporate takeover of healthcare. He breaks down the GOP's plan to restore marketplace competition, the debate over Affordable Care Act (ACA) subsidies, and why he believes the current system prioritizes corporate profit over medical necessity. TikTok is set to remain in the U.S. following a deal granting American entities majority ownership, ending the immediate threat of a nationwide ban. But does this restructuring resolve concerns over data privacy and the safety of young users? Cybersecurity expert John Cofrancesco joins to discuss whether the deal addresses the national security risks that sparked the ban, the legal battles over social media addiction, and the race to outpace China in artificial intelligence. Plus, commentary by FOX News contributor Tom Shillue. Learn more about your ad choices. Visit podcastchoices.com/adchoices

    Mayim Bialik's Breakdown
    Part Two: Mysterious CIA Medical Cases: Stanford Professor Garry Nolan on UAP Contact, Energy Weapons, Havana Syndrome, and How Alien Life Might Really Look

    Mayim Bialik's Breakdown

    Play Episode Listen Later Jan 28, 2026 41:15


    If you've ever wondered, “What's actually real when it comes to UAPs, aliens, and nonhuman intelligence?”...today, you're getting real answers. This episode of Mayim Bialik's Breakdown cuts through decades of speculation, misinformation, and stigma to bring you hard science, firsthand research, and never-before-shared insights from one of the most credible scientists studying UAPs today. For years, the public has been left guessing—Are UFOs real? Are aliens visiting us? Are people actually being harmed? And why won't mainstream science touch this topic? That changes today. We're sitting down with Dr. Garry Nolan, Professor of Pathology at Stanford University School of Medicine, Co-Founder and Executive Director of the Sol Foundation (a leading research institute focused on Unidentified Aerial Phenomena), and a featured expert in the hit documentary The Age of Disclosure. Dr. Nolan explains how he scientifically proved the infamous Atacama “alien” skeleton was not extraterrestrial, revealing what the DNA of true nonhuman life might actually look like if we ever encounter it. We also explore his classified-adjacent work studying UAPs, including deeply unsettling cases of alleged human injuries linked to possible UAP encounters and energy weapons, and the shocking implications these cases may have for regions of the human brain tied to intuition, perception, and consciousness itself. Dr. Nolan shares what he's uncovered from analyzing alleged UAP artifacts, including materials connected to Roswell, and how his lab studies metal fragments containing anomalies that appear to defy known physics. This episode goes where most won't—and does so with data, restraint, and scientific rigor. We're breaking down: - Why the Atacama “alien” skeleton fooled the world, and how science finally solved it - What alien or nonhuman DNA would actually look like (and why Hollywood gets it wrong) - What UAP-related human injury cases may reveal about the brain, intuition, and perception - How alleged UFO materials and Roswell fragments are analyzed at the atomic level - What Dr. Nolan believes the true goal of nonhuman intelligence might be - Why he thinks aliens should allow humanity to evolve naturally before further interference - What he personally witnessed as a child involving UAPs and nonhuman intelligence - How he responds to skepticism and backlash from fellow scientists - And whether humanity faces a physical or existential risk from alien contact This is not science fiction. This is cutting-edge science colliding with the biggest mystery of all time. Once you hear this, you may never look at reality the same way again. The Sol Foundation: ⁠http://www.thesolfoundation.org⁠ Follow us on Substack for Exclusive Bonus Content: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bialikbreakdown.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BialikBreakdown.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube.com/mayimbialik⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

    Terrible Lizards
    S12E01 African Prosauropods

    Terrible Lizards

    Play Episode Listen Later Jan 28, 2026 56:22


    You can watch this episode as a video on youtube: https://youtu.be/C2atVWsvkS0 To support the show/get bonus content: www.patreon.com/terriblelizards We've barely mentioned African dinosaurs (apart from you-know-what) over the years and have repeatedly failed to give much love to the early sauropodomorphs either (the 'prosauropods'). Happily, this month we're getting a great two-for-one deal by speaking to Kimi Chapelle who tells us all about her work on the incredibly well-represented, but not actually that well-studied Massospondylus. This species is known from dozens of complete skeletons but has attracted surprisingly little attention in the scientific literature and Kimi has been working to correct that with a whole series of projects on this animal and its relatives. There's plenty to discuss and more to come on these overlooked dinosaurs, so headphones on and enjoy. Please support the podcast and get access to bonus content: https://www.patreon.com/terriblelizards Kimi's website: Kimberley (Kimi) Chapelle | Renaissance School of Medicine at Stony Brook University https://renaissance.stonybrookmedicine.edu/anatomy/people/facultypage/chapelle  A profile of her and her work from the Superscientists website: Dinova - Kimberley Chapelle — SuperScientists https://www.superscientists.org/superscientists/chapelle  

    Sensible Medicine
    This Fortnight in Medicine XVIII

    Sensible Medicine

    Play Episode Listen Later Jan 28, 2026 45:36


    No video this week — we had a bit of a computer meltdown — but two interesting articles.As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at sensiblemedicine2022@gmail.com.This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

    REBEL Cast
    REBEL MIND: The Power of Performance Coaching in Medicine

    REBEL Cast

    Play Episode Listen Later Jan 28, 2026 30:35


    🧭 REBEL Rundown 📌 Key Points 💪 Building Resilience: Rebel MIND, in partnership with Arena Labs, introduces a science-based performance coaching platform specifically tailored for healthcare professionals, focusing on stress management and burnout prevention.🤝 Personal Insights: Jackie Penn shares her journey from exercise science to digital coaching, highlighting the importance of tailored coaching in high-pressure environments like healthcare.🎯 Clinician-Centric Approach: Understanding unique challenges faced by ER doctors, the program provides practical tools for stress and transition management, improving both professional and personal life balance.💻 Revolutionary Wearables: Utilizing wearables, the program offers objective feedback on recovery and health metrics, allowing personalization of strategies to enhance clinician well-being. Click here for Direct Download of the Podcast. 📝 Introduction Welcome back to REBEL MIND, where MIND stands for Mastering Internal Negativity during Difficulty. Here we sharpen the person behind the practitioner by focusing on things that improve our performance, optimizing team dynamics and the human behavior that embodies the hidden curriculum of medicine. In this episode, we’re excited to continue collaboration with Arena Labs, where host Dr. Marco Propersi interviews Jackie Pen, Heading of Performance Coaching at Arena Labs. Arena Labs is helping us measure healthcare performance through innovative programs designed to combat burnout and enhance personal wellness using data-driven strategies.  🔙Previously Covered on REBEL MIND: Performance Under Pressure – What Medicine Can Learn from Elite Teams 🤔Cognitive Question How do specific performance coaching strategies and tools assist healthcare professionals, particularly those in emergency medicine, in managing stress and preventing burnout effectively? 💭 Why This is Important Burnout among healthcare workers is a growing concern, especially in such high-pressure environments as emergency and intensive care units. The collaboration with Arena Labs brings forth a vital focus on using data and coaching to build resilience among medical professionals. 🏥How This Applies to the Emergency Department or ICU? In the chaotic and high-stakes environment of the ED/ICU, healthcare professionals are often required to make split-second decisions under pressure while managing emotional stress. This necessitates not just clinical acumen but also strong emotional resilience and stress management skills. Performance coaching provides the tools and frameworks to enhance these skills, offering strategies like the de-stress breath and transition protocols to help clinicians navigate between high-pressure situations efficiently. These tools are designed to not only improve their professional performance but also ensure they are emotionally present for their personal lives, ensuring a healthier work-life balance. ⏩ Things You Can Do on Your Next Shift Practice the De-stress Breath: Before moving from one critical case to another, take a moment to take two inhales through the nose followed by an extended exhale, helping to reset your nervous system by activating your parasympathetic nervous system.Implement a Transition Protocol: Choose a point in your journey home to mentally switch from clinician to family member, helping you to be more present outside of work.Optimize Your Nutrition and Rest: Even small changes during your shift, like meals that promote easy digestion or quick physical activities, can make a significant difference in your energy levels.Engage with Wearables: If possible, use wearables to monitor your physiological responses, helping tailor personalized strategies for your shifts 👀 Where to Learn More Intrigued by the possibilities this partnership offers? You can explore more by visiting Arena Labs’ website here. Also, check out the comprehensive coaching program available, designed specifically for healthcare providers looking to enhance their well-being and performance. 🚨 Clinical Bottom Line In an era where burnout is pervasive, our collaboration with Arena Labs offers a beacon of hope for healthcare workers. By leveraging cutting-edge data insights and practical coaching, this partnership aims to redefine healthcare wellness, fostering a sustainable, resilient workforce that’s equipped to navigate the pressures of modern medicine. Join us in this journey towards enhanced well-being and workforce empowerment, ensuring that those who care for us are also cared for. Meet the Authors Marco Propersi Co-Editor-in-Chief Vassar Brothers Medical Center, Poughkeepsie, NY Jackie Pen Head of Performance Coaching Arena Labs The post REBEL MIND: The Power of Performance Coaching in Medicine appeared first on REBEL EM - Emergency Medicine Blog.

    LifeSpa: Ayurveda Meets Modern Science
    Podcast Episode 165: Dosha Deep Dive to Understand Your Ayurvedic Body Type

    LifeSpa: Ayurveda Meets Modern Science

    Play Episode Listen Later Jan 28, 2026


    In this episode of the Ayurveda Meets Modern Science Podcast, learn everything you need to know about Ayurvedic body types. Dr. John offers a comprehensive breakdown of the doshas (vata, pitta, and kapha), how they are linked to nature's circadian rhythms, and how to understand your personal body type to improve your life and your health. The post Podcast Episode 165: Dosha Deep Dive to Understand Your Ayurvedic Body Type appeared first on John Douillard's LifeSpa.

    NEJM This Week — Audio Summaries
    NEJM This Week — January 29, 2026

    NEJM This Week — Audio Summaries

    Play Episode Listen Later Jan 28, 2026 25:46


    This week, we explore new therapies to reduce pancreatitis risk in severe hypertriglyceridemia, advances in breast cancer treatment, and long-term results of gene therapy for hemophilia B. We discuss vision-threatening vascular emergencies, the mental health effects of firearm injury on families, and care for peripheral artery disease. We also follow a revealing diagnostic case in an older woman with respiratory failure. Perspectives reflect on hypertension control, immunization access, chronic disease policy, and on the inherited risk of disease.

    Intelligent Medicine
    Brain Health Breakthroughs: Natural Approaches to Migraine Relief, Part 1

    Intelligent Medicine

    Play Episode Listen Later Jan 28, 2026 28:14


    Unraveling Migraines with Dr. Elena Gross, an expert on migraines and brain metabolism. She is the founder and CEO of KetoSwiss and MigraKet, is a passionate neuroscientist, has a PhD in clinical research, and is a former chronic migraine sufferer. Dr. Gross discusses her personal journey with chronic migraines and how it led her to develop innovative, natural approaches to migraine relief. She does a deep-dive into the nuances of brain energy, metabolism, oxidative stress, and the role of ketone bodies. Dr. Gross highlights her product line 'Brain Ritual' and how it can support brain health and tackle migraine symptoms. She also touches on the broader implications of these approaches for various neurodegenerative and psychiatric conditions. The discussion aims to offer practical solutions and a holistic understanding of brain health.Click here for $30 off your purchase of Brain Ritual.

    Intelligent Medicine
    Brain Health Breakthroughs: Natural Approaches to Migraine Relief, Part 2

    Intelligent Medicine

    Play Episode Listen Later Jan 28, 2026 45:01


    Dr. Hoffman continues his conversation with Dr. Elena Gross, an expert on migraines and brain metabolism. She is the founder and CEO of KetoSwiss and MigraKet, is a passionate neuroscientist, has a PhD in clinical research, and is a former chronic migraine sufferer.

    The Universe Within Podcast
    Ep. 182 - Dr Darren Schmidt DC - Metabolic Health, Nutrition, Detoxification, Parasites, & Medicine

    The Universe Within Podcast

    Play Episode Listen Later Jan 28, 2026 99:45


    Hey everybody! Episode 182 of the show is out. In this episode, I spoke with Dr Darren Schmidt DC. Dr Schmidt was recommended to me, and I really enjoyed some of his content on YouTube. We sat down and spoke about a variety of topics, including agriculture, nutrition, health, subsidies, detoxification, parasites, RFK, medicine, and a lot else. I think Dr Schmidt is doing great work at sharing more holistic medicine and think and trust you all will gain much from his experience and teachings. As always, to support this podcast, get early access to shows, bonus material, and Q&As, check out my Patreon page below. Enjoy!To learn more about or contact Dr Schmidt, visit his website at: https://thenutritionalhealingcenter.comTo learn more about our work, visit our website: https://NicotianaRustica.org To view the recent documentary, Sacred Tobacco, about my work, visit: https://youtu.be/KB0JEQALI_wI will be guiding our next plant medicine dietas with my colleague Merav Artzi (who I interviewed in episode 28) in:February 2026: Sacred Valley of PeruJune 2026: Remote Online DietaJuly 2026: Westport, IrelandNovember 2026: Sacred Valley of PeruIf you would like more information about joining us and the work I do or about future retreats, visit my site at: https://NicotianaRustica.orgIntegration/Consultation call: https://jasongrechanik.setmore.comPatreon: https://patreon.com/UniverseWithinYouTube join & perks: https://bit.ly/YTPerksPayPal donation: https://paypal.me/jasongrechanikWebsite: https://jasongrechanik.comInstagram: https://instagram.com/JasonGrechanikFacebook: https://facebook.com/UniverseWithinPodcastMusic: Nuno Moreno: https://m.soundcloud.com/groove_a_zen_sound & Stefan Kasapovski's Santero Project: https://spoti.fi/3y5Rd4H

    The Sleep Is A Skill Podcast
    250: Jonathan Robinson, Psychotherapist & Best-selling Author: MDMA Therapy and the Nervous System Reset

    The Sleep Is A Skill Podcast

    Play Episode Listen Later Jan 28, 2026 53:44


    Jonathan Robinson is a former psychotherapist and author of 16 books.  He has been a frequent guest on Oprah and CNN, and is well known for his groundbreaking work with MDMA assisted therapy.  He has led over 600 MDMA sessions with people over a 40 year period.  His books about MDMA include "Ecstasy as Medicine" and "Ecstasy for Couples."   SHOWNOTES:

    The Real Estate Vibe!
    Ep 222: From Medicine To Multiplying Wealth

    The Real Estate Vibe!

    Play Episode Listen Later Jan 28, 2026 53:44


    Send us a textIn this transformative episode of The Wealth Vibe Show, host Vinki Loomba dives deep with Dr. Ajay Goyal—a seasoned radiologist, visionary entrepreneur, and healthcare trailblazer. Together, they unpack how medical professionals can turn clinical practice into a high-performing wealth-building engine.Key Takeaways:The Business of Medicine: Dr. Goyal explains how owning your medical practice—along with the real estate it operates in—can create long-term equity, stability, and tax advantages.From Practitioner to Owner: Learn how Dr. Goyal scaled from one radiology clinic to founding Independent Healthcare Partners and a debt fund model aimed at transforming rural healthcare and physician ownership.Real Estate as a Wealth Lever: Discover why banks prefer physician-occupied buildings and how Dr. Goyal structured his deals to maximize equity and control.A Turnkey Investment Model: Dr. Goyal reveals how his firm identifies underserved communities, partners with local physicians, and uses a debt fund to offer short-term, high-yield investment opportunities—delivering returns of 10–16% annually.Impact + Income: This episode shows how investing in healthcare isn't just financially smart—it's a socially impactful move that improves access to quality care in rural America.Episode Timestamps:00:00 - 02:30: Intro to Dr. Goyal's background and wealth-building vision02:30 - 06:00: First real estate deal and the turning point in his investment journey06:00 - 10:00: Scaling the model—physician partnerships and wealth strategies10:00 - 15:00: Launching the debt fund and building infrastructure for rural healthcare15:00 - 20:00: Risk management, backup plans, and the physician transition model20:00 - 26:00: Operational insights, staffing, and patient acquisition26:00 - 32:00: Why debt over equity—fund structure and investor safeguards32:00 - 38:00: Investor underwriting, pro formas, and performance benchmarks38:00 - 44:00: Red flags investors should watch for and how to vet operators44:00 - 50:00: The future of medical real estate in a digital age50:00 - 53:30: Rapid-fire round: Best investment, daily habits, wealth philosophy

    Blue Sky
    From Prison to PhD, the Inspiring Life and Work of Dr. Stanley Andrisse

    Blue Sky

    Play Episode Listen Later Jan 28, 2026 54:04


    Before Stan Andrisse was sentenced to ten years in prison for a Class A drug felony, the prosecutor had asked for a life sentence, suggesting that the defendant was irredeemable.  In the years since, Stan, now "Dr. Andrisse" has proved this attorney and many others wrong.  While in prison, he discovered an interest in science and endocrinology and today is a tenured professor at the Howard University College of Medicine.  To create similar opportunities and career paths for others who are or have been incarcerated, he founded the non-profit From Prison Cells to PhD.    Chapters:   00:00 Introduction to Dr. Stan Andrisse  This chapter introduces Dr. Stan Andrisse a tenured faculty member at Howard University and the founder of "From Prison Cells to PhD."   02:40 Early Life and Incarceration  Dr. Andrisse discusses his childhood in Ferguson, Missouri, and how he became involved in illegal activities from a young age. He describes his progression from minor trouble to serious drug dealing, leading to multiple felony convictions and facing a potential life sentence under the three-strikes law.  07:58 The Incarceration of the Mind  Stan reflects on the profound psychological impact of being labeled a career criminal and facing a lengthy prison sentence. He emphasizes that the 'incarceration of the mind' is more damaging than physical imprisonment and describes how a mentor helped him begin to overcome this despair.  12:58 Mentor and Path to Education  Stan details the pivotal role of Dr. Barry Bodie, who supported him during his sentencing and continued to mentor him in prison. He explains how reading scientific articles, prompted by his father's death from diabetes, liberated his mind and ignited his passion for science, leading to his acceptance into St. Louis University despite multiple rejections.  22:33 Talent, Opportunity, and Innovation  Stan discusses his philosophy that talent is evenly distributed, but opportunity is not, using his own journey as an example. He highlights the untapped brilliance within incarcerated individuals, arguing that with resources and opportunities, their innovative problem-solving skills could benefit society greatly.  28:40 From Prison Cells to PhD: The Organization  Stan explains how his personal transformation inspired the creation of "From Prison Cells to PhD," a nonprofit scaling the mentorship and resource provision he received. He shares the organization's three core tenets: peer mentorship, community building, and connecting people to resources, detailing its significant success in helping formerly incarcerated individuals pursue higher education and careers.  34:07 Impact and Pen Pal Program Stan discusses the remarkable matriculation and GPA rates of participants in his "From Prison Cells to PhD" program. He explains how the organization reaches incarcerated individuals through partnerships with correctional facilities and its impactful pen pal program, which provides a vital connection to the outside world and instills hope, preventing recidivism.  41:35 The Drive to Succeed and Give Back  Stan highlights the unique motivation and grit of formerly incarcerated individuals, driven by a desire to prove their worth and contribute positively to society. He notes that their experiences with hardship often translate into loyalty, hard work, and a commitment to making communities better and safer.  45:29 Breaking Chains, Building Futures, and Final Thoughts  Stan discusses his new book, "Breaking Chains, Building Futures," which features diverse stories of individuals helped by his organization.  He encourages listeners to support "From Prison Cells to PhD" through their website and social media, emphasizing the continued inspiration he draws from his father's motto: "It's Never Too Late to Do Good." 

    Sea Change
    Wetlands Radio: Part 3

    Sea Change

    Play Episode Listen Later Jan 28, 2026 30:07


    Oil and gas canals. You've likely heard about the canals—tens of thousands of them, ever-widening, shredding the wetlands. The canals are what some scientists say is Louisiana's major cause of land loss. In Part 3 of our collaboration with Wetlands Radio, we explore the impact of canals, why industry has gotten away with the damage, and what's being done about it now.And then, what does it actually look like for Big Oil to clean up after itself? We bring you an interview about the current, controversial lawsuits aiming to hold the oil and gas industry accountable for the ways they've altered the landscape. EPISODE CREDITSThis episode was hosted by Executive Producer Carlyle Calhoun and Wetlands Radio producer Eve Abrams. Wetlands Radio is produced by Eve Abrams and funded by BTNEP, the Barataria Terrebonne National Estuary Program through the Environmental Protection Agency's National Estuary Program. To hear Wetlands Radio episodes in their entirety, visit btnep.org. Sea Change is a WWNO and WRKF production. We are part of the NPR Podcast Network and distributed by PRX. Sea Change is made possible with major support from the Gulf Research Program of the National Academy of Sciences, Engineering, and Medicine. Sea Change is also supported by the Water Collaborative of Greater New Orleans. WWNO's Coastal Desk is supported by the Walton Family Foundation, the Meraux Foundation, and the Greater New Orleans Foundation. 

    Random Fit Powered by NASM
    Part II: What Do Fairy Tales Teach Us About Fitness?

    Random Fit Powered by NASM

    Play Episode Listen Later Jan 28, 2026 33:45


    What does the story of the Three Little Pigs have to do with your fitness journey? EVERYTHING! In this episode of the award-winning “Random Fit” podcast, hosts Wendy Batts and Ken Miller break down how to build a lasting, STRONG foundation for your workouts and healthy habits—so nothing (not even the Big Bad Wolf of setbacks) can blow your progress down.

    Think Neuro
    Meet Dr. Ashkan Mowla

    Think Neuro

    Play Episode Listen Later Jan 28, 2026 1:59


    Ashkan Mowla, MD, FAHA, FAAN, is neuro-interventional surgeon at the Pacific Neuroscience Institute® (PNI). He specializes in minimally invasive endovascular procedures to treat conditions and diseases of the brain and spine, including stroke, brain aneurysm, brain and spine arteriovenous malformation and fistula and carotid and intracranial disease. He is triple board-certified neurologist with fellowship training in stroke and cerebrovascular diseases and also interventional neuroradiology. Prior to joining PNI, he was an assistant professor of neurological surgery at the Keck School of Medicine, University of Southern California (USC), Los Angeles, CA for 5 years.

    New England Journal of Medicine Interviews
    NEJM Interview: Robert Kocher on strategies for improving blood-pressure control in the United States.

    New England Journal of Medicine Interviews

    Play Episode Listen Later Jan 28, 2026 6:42


    Robert Kocher is an adjunct professor at the Stanford University School of Medicine, a nonresident senior scholar at the University of Southern California Schaeffer Institute, and a partner at Venrock. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S.P. Kishore and R. Kocher. The Hypertension Control Paradox — Why Is America Stuck? N Engl J Med 2026;394:417-420.

    Continuum Audio
    Managing Prognostic Uncertainty in Neurologic Disease With Dr. Robert G. Holloway

    Continuum Audio

    Play Episode Listen Later Jan 28, 2026 22:48


    Clinicians and patients are in a state of prognostic uncertainty when they are unsure about the future course of an illness. By embracing uncertainty while cultivating prognostic awareness, neurologists can serve the critical role of supporting patients and families through the living and dying process. In this episode, Casey Albin, MD, speaks with Robert G. Holloway, MD, MPH, FAAN, author of the article "Managing Prognostic Uncertainty in Neurologic Disease" in the Continuum® December 2025 Neuropalliative Care issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Holloway is the Edward and Alma Vollertsen Rykenboer Chair and a professor of neurology in the department of neurology at the University of Rochester School of Medicine and Dentistry in Rochester, New York. Additional Resources Read the article: Managing Prognostic Uncertainty in Neurologic Disease Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello, this is Dr Casey Albin. Today I'm interviewing Dr Bob Holloway about his article on managing prognostic uncertainty in neurologic disease, which appears in the December 2025 Continuum issue on neuropalliative care. Welcome to the podcast, and please introduce yourself to our audience. Dr Holloway: Hi, Casey, and thank you. Again, my name is Bob Holloway. I'm a clinician and neurologist up in Rochester, New York, and I've been doing both neurology and palliative care for many years. Dr Albin: Well, that's fantastic. And I really wanted to emphasize how much I really enjoyed reading this article. I know that we're going to get into some of the pearls that you offer, but I really want to tell the listeners, like, this is a great one to read because not only does it have sort of a philosophical take, but you also really provide some pragmatic tips of how we can help our patients manage this prognostic uncertainty. But maybe just tell us a little bit, what is prognostic uncertainty? Dr Holloway: Yes, thank you. Well, I think everyone has a sense of what prognostic uncertainty is. And it's just the uncertain futures that we as clinicians and our patients face. And I would just say that a way to summarize it is just, how do we manage the "not yet" of neurologic illness? Dr Albin: I love that. In neurologic illness, there is so much "not yet" and there are so many unknowns. And what I thought was really helpful about your article is you kind of give us three buckets in which we can think about the different types of uncertainty our patients are facing. What are those? Dr Holloway: This is, I think, an area that really is of interest to me, thinking about how to organize the prognostic "not yet" or that landscape. And one way I've tried to simplify it is to think about it as data-centered. And that's the world that we mostly live in as neurologists. That's the probability distributions. We also have kind of system-level uncertainties, and that's the uncertainties that our health system affords for our patients. And then we have, also, the patient-centered uncertainties and the uncertainties that those two prior categories cause for our patients. And that's a big uncertainty that we often don't address. Dr Albin: In reading the article, I was really struck by, we spend a lot of time thinking about data uncertainty. Can we get population-based research? Can we sort of look at prognostication scoring? I live in the ICU, and so we think a lot about these, like, scoring metrics and putting patients into buckets and helping us derive their care based on where their severity index is. And I'm sure that is true in many of the divisions of neurology. But what I did not really appreciate---and I thought you did a really fantastic job of kind of drawing our attention to---is there's a lot of system-centered uncertainty. Can you give us a little bit of examples, like, what is system-based uncertainty? Dr Holloway: I think system-level uncertainties just encompass the practical information gaps that may arise during our healthcare encounter. And a lot of, I think, the uncertainty that our patients face and families, they actually describe it as they feel captive by the uncertainty. And it's just the unknowns, not just what affords from the actual information about the disease and its prognosis in the future, but actually the level of the system, like, who's going to take care of them? How do you manage arranging for nurses to come into the home or all those practical-level uncertainties that the system provides that sometimes we don't do a good job of road-mapping for patients. Dr Albin: Absolutely. Because I feel like we have a little bit of a gap in that often as physicians. Like, the family asks, what will hospice at home look like? Well, you know, that's a question for case management. I think they'll come in and they'll tell you. But it strikes me that that's a real gap of my being able to walk patients through. Will they get home health care? Will they have transportation set up? Will there be a nurse who comes in to check? How often are they available? What's the cost going to be? All of these practical aspects of dealing with an illness that are beyond sort of our scope of knowledge, but probably have a huge practical impact to the patient. Dr Holloway: Without question, every encounter patients wonder about, that kind of future wish landscape that we- all our future-oriented desires and hopes. And so much of that is the practical aspects of our health system, which is often fragmented, kind of unknown, uncertain. And that's a huge source of uncertainty for our patients and families. And then that leads to many other uncertainties that we need to address. Dr Albin: Absolutely. I think another one that we, again, maybe don't spend quite as much time thinking about is this patient-level uncertainty. What's going on there? Dr Holloway: Yeah. So, I think patient-level uncertainty is that uncertainty that they experience when confronted with the two other types of uncertainty: the actual data-centered uncertainty and the system-level uncertainty. And that's that, kind of, very huge kind of uncertainty about what it means for them and their family and their future futures. And that's a source of huge stress and anxiety, and often frankly bordering on dread and fear for our patients and families. That actually gets into very levels of uncertainty that I would call maybe over even in the existential realm. Patient-level uncertainty in the actual existential questions or the fear and the dread or the kind of just unnerving aspect of it is actually even more important to patients than the scientific or data-centered uncertainty that we focus most of our attention on. Dr Albin: Yeah, I think this is, to me, was getting towards that, like, what does the patient care about and how are they coping with what is in many times a really dramatic shift in their life expectancy or morbidity expectations and this sort of radical renegotiation about what it means to have a neurologic illness? And how does that shift their thinking about who they are and their priorities in the world? Is that right? Dr Holloway: One thousand percent, and in fact, I will say---and I think is one of the main take home messages is that, you know, managing prognostic certainty is not an end in itself. It really is to help patients and families adaptively cope to their new and often harsh new reality, that we could help them adapt to their new normal. I think that is one of our main tasks as neurologists in our care teams is to help patients find and ultimately maybe achieve existential or spiritual or well-being even in their new health states. You know, that you certainly often see in the intensive care unit, but we often always see in the outpatient realm as well, and all our other diseases. Dr Albin: I think that's really hard to do. I think those conversations are incredibly difficult and trying to navigate where patients want to be, what would bring meaning, what would bring value. I think many of us struggle to have these pretty real and intense conversations with families about what really is important. And one of the things I really liked about this article is you kind of walk us through some steps that we as clinicians can take to get a little bit more comfortable. Maybe just walk us through, what are some of the things that you have found most helpful in trying to get families and patients to open up about what brings them meaning? How are they navigating this new, really uncertain time in their life? Dr Holloway: Yeah, so I do kind of have a ten-point recommendations of how to help cultivate a more integrated awareness of an uncertain future. I mean, I think the most important thing is actually just recognizing that embracing uncertainty as an amazingly remarkable cognitive tool. I mean, let's face it, uncertainty, when it happens with neurologic illness and disease, is often fearful. It's scary. It kind of changes our world. But on the flip side of it, it's a remarkable cognitive tool that actually can help us find new ways and new paths and new creativity. And I think we can use that kind of opposites to help our patients find new meaning in very difficult situations. So, thinking about uncertainty, kind of being courageous, leaning into it and recognizing that it does create anxieties and fear, but it also can kind of help create new solutions and new ideas to help people navigate. Dr Albin: I was hoping that maybe you could give us an example of, like, how would you do that? If a patient comes in and they're dealing with, you know, a new diagnosis and they're navigating this new uncertainty, what are some of the things that you ask to help them reframe that, to kind of take some of the good about that uncertainty? How do you navigate that? Dr Holloway: One of the other recommendations is actually just resetting the timeline and expectations for these conversations. That it shouldn't be expected that patients should accept their harsh new reality immediately, that it takes time in a trusted environment. And that there's this, like, oscillating nature of hopes and fears and dread, and you've just got to work with them over time. And with time, and once you understand who the patient and family are and understand where they find meaning and where they find, actually, joy in their life, or what actually brings them meaning, you can start recasting their futures into credible narratives in their kind of future landscape in ways that I think can help them enter into their new realities within the, you know, framework of disease management that you can offer them within your healthcare team or your healthcare system or wherever you are in the world and the available resources that you have to offer patients and families. Dr Albin: So, this sounds like a lot to me like active listening and really trying to get to know what is important to the family, what is important to the patient. And I guess probably just creating that space even in that busy clinical environment. Do I have that right? Dr Holloway: You can absolutely do that, right. You know, and honestly, active listening, we are challenged in our busy healthcare system to do this, but I think with the right listening skills and the appropriate ways of paying attention, you can definitely illuminate these possible, kind of future-oriented worlds for patients and help them navigate those new terrains with them. Frankly, I think that's a real new space for us in neurology. We don't think about and train how to create credible narratives for patients and families. We do it on the fly, but I think there's so much more work to do. How do you actually keep, you know, that best-case, worst-case, most likely credible narratives for patients that can help them adapt to their new realities and support them on their new journeys? Dr Albin: I love that best-case, worst-case, most likely case. I find that framework really helpful. But you talk in your article, it's not just about using that best case or worst case or most likely, but it's actually building some forecasting into that and having some real data to kind of support what you're saying. And there's a lot of growth towards actually becoming good as a medical forecaster. Can you describe a little bit, what did you mean by that? Dr Holloway: You're absolutely right. I think, actually, one of the skillsets of becoming and managing prognostic uncertainty is actually becoming a skilled medical forecaster. And it's a really tall order. So, we've got to be both good medical forecasters as well as helping patients adaptively cope to their new reality. But the good medical forecasting is actually now going more quantitative in thinking about the data that's available to help think about the important outcomes for patients and families and then predicting what their probabilities are so you can shape those futures around. So, yes, we do have to have an open mindset. We do have to actually look at the data that's available and actually think about, what are those long-term probabilities and outcomes? And we can be honest about those and even communicate them with families. But it's a really good skill set to have. Dr Albin: Yeah. This to me was a little bit about, how do you bring in the data knowledge that we try to get over time as we develop our expertise? You're developing not just a reliance on population-based data, but in my experience, I have seen this. And that sort of ability to kind of look at the patient in front of you, think about the big picture, but also a little bit about their unique medical comorbidities or prior life experiences. So, some of that database knowledge, and then bringing in and getting to know what is important to the patient. And so, sort of marrying that data-centric/patient-centric mindset. Dr Holloway: I love it. I guess the other way of saying that, too, is we need to think with precision, but communicate in narratives. And it's okay to gently put more precise estimates on our probability predictions with patients and families, what we think is the most likely case, best and worst case. Because patients and families want us to be more precise. We often shy away from it, but- so, it's okay to think in precisions, but we've got to put those in narratives in the most likely, best-, and worst-case scenarios. And don't be afraid if you think in terms of ninety percents, ten percents, fifty percents; most patients and families don't mind that. And what they're telling us is they actually want to hear that, if you are comfortable talking in those terms. Dr Albin: Yeah, absolutely. And giving a sense of the humility to say, like, this is my best guess based on medical data and my experience, I would say, but again, none of us have a crystal ball. And I do think families, as long as you're sort of couching your expectations into the sort of imperfect, but I'm doing my best, really appreciate that. Dr Holloway: They totally do all the time. Just say, I simply don't know for certain, but these are my best estimates. That's a good way of just phrasing that. Dr Albin: Yeah. So powerful. I don't know for certain. And then I wanted to just kind of close out, because there's this one term that you use that I thought was so interesting. And I wanted you to kind of tell our listeners a little bit about what you mean here, which is that, when you're actively open-minded, you're using this, quote, "dragonfly eyes." What do you mean by that? Dr Holloway: So, the dragonfly eyes, as you know, they can look at three sixty around them and they just, they move in all directions. Being actively open minded, I guess the biggest example I would say is, I don't like the term prognostic discordance, which means that there's a difference of subjective estimates of prognosis between patients and families. Being openly minded is actually embracing the potential information that the family has about prognosis and incorporating that into your estimates. So, I wouldn't say it's discordances, per se; I think being really actively open-minded is taking that all in and utilizing that as, you know what, they know more than you do about the patient and their loved ones, and they may have insights that can inform your best estimates of prognosis. So, the true dragonfly prognosticator actually is one who embraces and doesn't consider it discord, but considers it kind of new, useful information that I just need to weigh in so I can help the family in my best professional way in terms of developing a prognosis, whatever the condition may be. Dr Albin: I can imagine this is just so challenging and something that takes a long time to sort of perfect all of this. I think you say right below that, you need a growth mindset to do this because it is hard, and it's going to take an active participation and an active desire to get better at these conversations with our families. Dr Holloway: One thousand percent. You are so right that it takes time, effort, and not feeling like you're being challenged, but that actually you are including them in your entire body of knowledge, that you're just- it's part of all you're collecting. And even, I was on service last week, and I talked to residents and students about that very issue. It's like take their prognosis. And someone who came in, we thought CJB, very sad, tragic case, but we were thinking about what the future may look like and how do we actually work with the family who had very what we thought was unrealistic expectations. I said, well, no, this is not discordance. This is just useful information that we can take understand where they're coming from and incorporate that into the ways we want to build relationships, build trust, and over time we'll get to a point where we hopefully can work with them and have them have that fully integrated awareness of their future. Dr Albin: Yeah, that's beautiful. It really is this ongoing negotiation that really requires so much listening, understanding, and then obviously information and expertise about the data that we're presenting and the likelihood outcome, recognizing that there's a lot of uncertainty in all of this. Which, you know, again, this is kind of a 360 talk. At every level there is uncertainty, and that's what makes it so hard. Dr Holloway: Yeah, you're absolutely right. And actually, even in the article I kind of used the term radical uncertainty as that, no matter how resolvable all this uncertainty is, there will always still remain that radical element of our existence which we have to actually incorporate and be prepared for. And actually, not only of ourselves, but actually for patients and families and helping manage that. Using narratives and credible narratives and kind of ranges of possibilities is the best way to do that in a personalized way. Dr Albin: Well, this has been a fantastic conversation, and I know that we are running a bit short on time. So, as we wrap up and you think about this topic, are there any key take-home messages that you hope our listeners will walk away with? Dr Holloway: I think one main emphasis is that despite all the successes we feel we have in neurology, is that we all have to recognize that prognostic uncertainty is just going to increase in the future. But this is going to be for several reasons. One is that, just, the illness uncertainty of all of our great therapies are just going to be creating more uncertainty for the future. And precision medicine is paradoxical, and that actually it creates more uncertainty. So, I think we need to be prepared that we have to manage prognostic uncertainty better, because it's definitely going to increase. And two, it's what I said earlier, is that actually managing prognostic uncertainty is not an end to itself. It's actually helping patients and families adapt to their new and sometimes harsh new reality and actually help them to ultimately get to a place where maybe either their condition is neither dreaded, but actually they can accept it as their new reality and actually achieve some sort of existential well-being and existential health. I think that we have a lot more to emphasize in this area. And for far too long, we've focused on the certainty aspect of our field and not enough on the uncertainty in the world of medicine to help our patients and families. Dr Albin: And gosh, isn't there just so much uncertainty? And I think this has been beautiful. So, thank you again for coming and sharing your expertise. Dr Holloway: Thank you very much. It's been a pleasure. Dr Albin: For all of our listeners out there, this is a truly fantastic article, and I would just like to direct you to going to read the cases because not only do the cases offer a little bit of practical advice, but there's one that's actually sort of a philosophical discussion about, what does it mean to be alive and confront death? There's some beautiful artwork that's featured as well. So this is just a really unique article, and I'm excited for our listeners to have a chance to check it out. So again, today I've been interviewing Dr Bob Holloway about his article on managing prognostic uncertainty in neurologic disease, which appears in the December 2025 Continuum issue on neuropalliative care. Be sure to check out Continuum Audio episodes from this and other issues. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

    20-Minute Health Talk
    Building healthier cities: A conversation with Ashwin Vasan, MD, part 1

    20-Minute Health Talk

    Play Episode Listen Later Jan 28, 2026 19:27


    Host Chethan Sathya, MD, discusses the challenges and opportunities of improving public health with the former commissioner of NYC's Department of Health and Mental Hygiene, Ashwin Vasan, MD. In this 3-part conversation, Dr. Vasan delves into his inspiring journey into medicine. With family tragedies, namely polio, and successes fueling his passion, Dr. Vassan discusses the vital role of storytelling in enacting systemic change. Guided by influential mentors, he emphasizes the need for engagement, empathy, and impactful results in public health initiatives. This is Part 1 of this series. Listen to Part 2 Listen to Part 3 About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 28 hospitals, 890 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit our career site and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. 

    20-Minute Health Talk
    Building healthier cities: A conversation with Ashwin Vasan, MD, part 2

    20-Minute Health Talk

    Play Episode Listen Later Jan 28, 2026 20:18


    Join host Chethan Sathya, MD, and former NYC Health Commissioner Ashwin Vasan, MD, for part two of our series exploring public health challenges. In this segment, Dr. Vasan addresses the opioid crisis, his leadership during tumultuous times, and the essential role of resilience. He shares insights from his diverse roles, highlighting the successful reduction in overdose deaths and how volatility spurred transformative strategies, ranging from mental health initiatives to efforts to tackle social media's impact. This is Part 2 of this series. Listen to Part 1 Listen to Part 3 About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 28 hospitals, 890 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit our career site and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. 

    20-Minute Health Talk
    Building healthier cities: A conversation with Ashwin Vasan, MD, part 3

    20-Minute Health Talk

    Play Episode Listen Later Jan 28, 2026 23:33


    In the final segment of this three-part series, host Chethan Sathya, MD, and former NYC Health Commissioner Ashwin Vasan, MD, discuss the critical need for rebuilding trust in public health. Dr. Vasan emphasizes the importance of open dialogue and empathetic engagement across communities, highlighting the challenges posed by societal divisions. As public health faces skepticism, he underscores the need to involve diverse perspectives to foster unity and chart a path toward a healthier, more inclusive future. This is Part 3 of this series. Listen to Part 1 Listen to Part 2 About Northwell Health Northwell Health is New York State's largest healthcare provider and private employer, with 28 hospitals, 890 outpatient facilities and more than 16,600 affiliated physicians. We're making breakthroughs in medicine at the Feinstein Institutes for Medical Research. We're training the next generation of medical professionals at the visionary Donald and Barbara Zucker School of Medicine at Hofstra/Northwell and the Hofstra Northwell School of Nursing and Physician Assistant Studies. For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. Get the latest news and insights from our experts in the Northwell Newsroom: Press releases Insights Podcasts Publications Interested in a career at Northwell Health? Visit our career site and explore our many opportunities. Get more expert insights from leading experts in the field — Northwell Newsroom.  Watch episodes of 20-Minute Health Talk on YouTube.  For information on our more than 100 medical specialties, visit Northwell.edu and follow us @NorthwellHealth on Facebook, Instagram, X and LinkedIn. 

    Sink or Swim Podcast
    In Her Scrubs: Perspectives of Women in Medicine

    Sink or Swim Podcast

    Play Episode Listen Later Jan 28, 2026 65:33


    This episode features a discussion of Women in Medicine. Featuring M4s: Kristina Reyes, Brittany Puebla, Nicole Starke.

    Category Visionaries
    How Doctronic became the first AI licensed to practice medicine through Utah's regulatory sandbox | Matt Pavelle

    Category Visionaries

    Play Episode Listen Later Jan 28, 2026 24:03


    Doctronic became the first AI in the world legally licensed to practice medicine through Utah's AI Learning Lab regulatory sandbox in December 2025. In this episode of BUILDERS, I sat down with Matt Pavelle, Co-founder and Co-CEO of Doctronic, to learn how he and his co-founder (a physician) launched an AI-powered primary care chatbot in September 2023, validated demand through Facebook chronic condition groups and minimal Google Ads spend, and navigated uncharted regulatory territory to offer $4 prescription renewals for chronic conditions—targeting the medication non-adherence problem that causes 125,000 preventable deaths and costs $100B annually. Topics Discussed: Why friends with excellent health insurance still couldn't get medical answers quickly Building clinical accuracy into GPT-3.5 when context windows were small and hallucinations were rampant The tactical launch: Google Ads plus Facebook chronic condition groups in September 2023 Architecting safety: RAG with tens of thousands of physician-written clinical guidelines The study: 99.2% agreement rate between AI treatment plans and human doctor reviews across 500 patients Navigating Utah's AI Learning Lab: the only regulatory sandbox that mitigated medical licensing laws Securing AI malpractice insurance through Lloyd's Market—a first in the industry The three-phase oversight model: 100% human review, then 10%, then spot checks Expansion strategy: targeting other state regulatory sandboxes and international governments GTM Lessons For B2B Founders: Launch with the minimum feature set that proves your core hypothesis: Pavelle shipped Doctronic in September 2023 without user accounts—chats disappeared when closed unless users saved them manually. Within days, user requests for persistent chat history validated demand. The insight: your MVP should test one assumption, not solve every user need. If you're hesitating to launch because features are missing, ask whether those features are actually required to validate your hypothesis or just things you assume users want. Use specificity to unlock early adoption in skeptical markets: Rather than targeting "healthcare" broadly, Pavelle posted in Facebook groups for specific chronic conditions, offering a free AI backed by clinical guidelines. Half the groups banned them for commercial activity, but the other half engaged immediately. The lesson: in regulated or skeptical markets, narrow targeting with explicit safety mechanisms (clinical guidelines, physician co-founder credibility) converts better than broad positioning. Identify where your skeptics congregate and address their specific objections upfront. Design system architecture to prevent failure modes, not just tune models: Doctronic's safety architecture separates AI decision-making from prescription execution. The LLM asks questions and determines renewal safety, but deterministic code outside the AI verifies the prescription exists, checks dosage accuracy, and confirms the schedule. Even if adversarial prompting compromises the LLM, the deterministic layer prevents bad outcomes. Founders building high-stakes AI products should architect multiple independent verification layers rather than relying on prompt engineering or temperature tuning alone. Target regulatory pain points with quantified deaths and costs: Pavelle approached Utah with specific numbers: 125,000 preventable deaths annually from medication non-adherence, 30-40% caused by renewal friction, and a $100B economic burden. These statistics—combined with Utah's rural population and physician shortage—made the problem impossible to ignore. When approaching regulators, lead with mortality and cost data that make inaction untenable, not just efficiency gains or convenience improvements. Regulatory sandboxes require proof of safety methodology, not just technology demos: Utah's AI Learning Lab didn't just grant Doctronic permission—they required a three-phase oversight structure where human physicians review 100% of initial prescriptions in each medication class, then 10%, then ongoing spot checks. Pavelle also secured AI malpractice insurance through Lloyd's Market before launch. The insight: regulatory innovation offices want risk mitigation frameworks, not promises. Build and fund your oversight methodology before approaching regulators, and treat insurance underwriting as a third-party validation of your safety claims. Publish clinical validation studies before scaling—they become your regulatory and sales asset: The study showing 99.2% agreement between Doctronic's AI and human physicians across 500 patient encounters became the foundation for regulatory conversations and public trust. Founders in regulated spaces should budget for formal validation studies early—these aren't marketing expenses, they're the permission structure for everything that follows. Work backward from what regulators and enterprise buyers need to see, then design studies that generate that specific evidence. // Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe. www.GlobalTalent.co // Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role. Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM

    Mayim Bialik's Breakdown
    Mysterious CIA Medical Cases: Stanford Professor Garry Nolan on UAP Contact, Energy Weapons, Havana Syndrome, and How Alien Life Might Really Look

    Mayim Bialik's Breakdown

    Play Episode Listen Later Jan 27, 2026 70:58


    If you've ever wondered, “What's actually real when it comes to UAPs, aliens, and nonhuman intelligence?”...today, you're getting real answers. This episode of Mayim Bialik's Breakdown cuts through decades of speculation, misinformation, and stigma to bring you hard science, firsthand research, and never-before-shared insights from one of the most credible scientists studying UAPs today. For years, the public has been left guessing—Are UFOs real? Are aliens visiting us? Are people actually being harmed? And why won't mainstream science touch this topic? That changes today. We're sitting down with Dr. Garry Nolan, Professor of Pathology at Stanford University School of Medicine, Co-Founder and Executive Director of the Sol Foundation (a leading research institute focused on Unidentified Aerial Phenomena), and a featured expert in the hit documentary The Age of Disclosure. Dr. Nolan explains how he scientifically proved the infamous Atacama “alien” skeleton was not extraterrestrial, revealing what the DNA of true nonhuman life might actually look like if we ever encounter it. We also explore his classified-adjacent work studying UAPs, including deeply unsettling cases of alleged human injuries linked to possible UAP encounters and energy weapons, and the shocking implications these cases may have for regions of the human brain tied to intuition, perception, and consciousness itself. Dr. Nolan shares what he's uncovered from analyzing alleged UAP artifacts, including materials connected to Roswell, and how his lab studies metal fragments containing anomalies that appear to defy known physics. This episode goes where most won't—and does so with data, restraint, and scientific rigor. We're breaking down: - Why the Atacama “alien” skeleton fooled the world, and how science finally solved it - What alien or nonhuman DNA would actually look like (and why Hollywood gets it wrong) - What UAP-related human injury cases may reveal about the brain, intuition, and perception - How alleged UFO materials and Roswell fragments are analyzed at the atomic level - What Dr. Nolan believes the true goal of nonhuman intelligence might be - Why he thinks aliens should allow humanity to evolve naturally before further interference - What he personally witnessed as a child involving UAPs and nonhuman intelligence - How he responds to skepticism and backlash from fellow scientists - And whether humanity faces a physical or existential risk from alien contact This is not science fiction. This is cutting-edge science colliding with the biggest mystery of all time. Once you hear this, you may never look at reality the same way again. Head to https://impact.ourritual.com/6yr65V , take a quick quiz, and use code BREAKER20 for 20% off your first month. Let Rocket Money help you reach your financial goals faster. Join at rocketmoney.com/breakdown Sign up for your $1 per month trial and start selling today at https://shopify.com/breakdown The Sol Foundation: http://www.thesolfoundation.org Follow us on Substack for Exclusive Bonus Content: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bialikbreakdown.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BialikBreakdown.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube.com/mayimbialik⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

    Angela Yee's Lip Service
    LS Episode 537: From Bravo to Ballots (feat. Dr. Heavenly Kimes)

    Angela Yee's Lip Service

    Play Episode Listen Later Jan 27, 2026 51:11 Transcription Available


    Dr. Heavenly Kimes from Married to Medicine joins Angela Yee and the Lip Service crew to talk about her historic run for Congress in Georgia, her reality-TV fame turning into political power, and the personal moments that shaped her journey. She opens up about the arrest of her son, discovering her half-brother years later, and why she refuses to exploit her marriage for reality TV — even when everyone else does. Heavenly also breaks down how healthcare cuts, Medicaid changes, and mental-health crises are hurting her district, and why she believes she was called to serve. From Bravo drama to Capitol Hill, this is one of the most unfiltered and revealing conversations Heavenly has ever had. Topics include:• Why she’s running for Congress• How reality TV prepared her for politics• Her son’s arrest and how it changed her• Why she won’t put her marriage on TV• Mental health, Medicaid, and Georgia voters• Drama with the Married to Medicine castSee omnystudio.com/listener for privacy information.

    The Doctor's Art
    Reclaiming Narrative in Medicine | Suzanne Koven, MD, MFA

    The Doctor's Art

    Play Episode Listen Later Jan 27, 2026 53:42


    Most medical encounters are structured as transactions. The patient comes in with a specific complaint, the medical expert identifies a discrete problem, and a specific intervention is prescribed.But at the heart of a medical encounter is a story. When a patient comes in with a medical problem, the problem cannot be disentangled from their life's narrative — doing so risks hollowing out the essence of what it means to care for another person. Our guest on this episode is award-winning author, and primary care physician Suzanne Koven, MD. Following the completion of her residency at Johns Hopkins Hospital, Dr. Koven joined the faculty at Harvard Medical School and practiced primary care medicine at Massachusetts General for 32 years. In 2019, she became the inaugural Writer in Residence at Mass General. Her writings have been published broadly—including in The Boston Globe, The New England Journal of Medicine, The Lancet, and The New Yorker. As a teacher and public speaker, she highlights the relationship between literature and medicine, and is a powerful advocate for female medical trainees. In this episode, Dr. Koven shares her journey to medicine at a time when few women were represented in the field and why she finds her undergraduate English classes to be more relevant to her clinical work than her science classes. We discuss narrative medicine, its value to patients and physicians alike, and how the modern healthcare system struggles to value the patient story. Finally, Dr. Koven leaves us with her advice for up-and-coming trainees: find a place in medicine where you can be yourself – for your own good and for your patients'.In this episode, you'll hear about: 3:00 - Dr. Koven's motivations for going into primary care medicine 15:49 - The impact that Dr. Koven's English degree has had on her approach to medicine 19:36 - What narrative medicine is 24:34 - What is lost when human connection and human story are deprioritized within the practice of medicine 31:15 - The benefits doctors experience when cultivating an appreciation for the arts37:21 - How gender representation in medicine has shaped Dr. Koven's experience as a physician42:54 - The need for the culture of medicine to adapt to changing demographics in the medical workforceIf you enjoyed this episode, please subscribe, rate, and review our show, available for free on Spotify, Apple Podcasts, or wherever you get your podcasts. If you know of a doctor, patient, or anyone working in health care who would love to explore meaning in medicine with us on the show, feel free to leave a suggestion in the comments or send an email to info@thedoctorsart.com.Copyright The Doctor's Art Podcast 2026

    The Gist
    Thomas Goetz: "Medicine works by helping some people a lot and most people not at all."

    The Gist

    Play Episode Listen Later Jan 27, 2026 30:55


    Thomas Goetz joins the show to discuss his new podcast Drug Story, starting with the chain from FDR's death to cholesterol science, statins, and the cold math behind drug effectiveness. The conversation moves through Lipitor and EpiPens to show how evolving medical knowledge, good intentions, and pharmaceutical incentives can quietly reshape public health at massive scale. Plus, Trump is perhaps rethinking his Minnesota deployments, as the fire trucks exit.  In the spiel a look at why the word "pretext" keeps surfacing in descriptions of Trump administration ICE actions, especially in Minnesota. What the term actually means, why it is often misapplied, and what its ubiquity reveals about how this administration justifies force before retreating. Produced by Corey Wara Coordinated by Lya Yanne Video and Social Media by Geoff Craig Do you have questions or comments, or just want to say hello? Email us at ⁠⁠⁠⁠thegist@mikepesca.com For full Pesca content and updates, check out our website at https://www.mikepesca.com/⁠ For ad-free content or to become a Pesca Plus subscriber, check out ⁠⁠⁠⁠https://subscribe.mikepesca.com/ For Mike's daily takes on Substack, subscribe to The Gist List https://mikepesca.substack.com/ Follow us on Social Media:⁠⁠⁠⁠ YouTube https://www.youtube.com/channel/UC4_bh0wHgk2YfpKf4rg40_g⁠⁠⁠⁠ Instagram https://www.instagram.com/pescagist/ X https://x.com/pescami TikTok https://www.tiktok.com/@pescagist To advertise on the show, contact ⁠⁠⁠⁠ad-sales@libsyn.com⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/TheGist

    As a Woman
    Muscle as Medicine: Strength Training for Hormonal Health | Gabrielle Lyon, MD

    As a Woman

    Play Episode Listen Later Jan 27, 2026 55:07


    Dr. Natalie Crawford sits down with physician and muscle-centric medicine expert Dr. Gabrielle Lyon to explore why skeletal muscle is a powerful driver of hormones, metabolism, fertility, and long-term health, and how women can begin to support it at any age. Key Topics: 1. Muscle as an Organ of Longevity - How skeletal muscle influences hormones, metabolism, inflammation, and aging - Why “muscle span” matters across childhood, reproductive years, and beyond - Rethinking muscle as essential biology rather than aesthetics 2. Fertility, Pregnancy, and Metabolic Health - How muscle relates to insulin resistance, embryo quality, and fertility outcomes - The role of muscle health before and during pregnancy - Why activity and resistance training are key in hormonally vulnerable seasons 3. Training and Nutrition Fundamentals - Practical ways women can start strength training at any level - The importance of stimulus, not perfection, for building and maintaining muscle - How protein intake and meal structure support muscle and body composition 4. Mindset, Stress, and Long-Term Resilience - How mindset can hold women back from building strength - Reframing stress, challenge, and discomfort in training and daily life - Focusing on what you can gain—in health, function, and confidence—over the long term Pre-order Dr. Crawford's debut book, The Fertility Formula, now! ⁠https://www.nataliecrawfordmd.com/book⁠ Website: https://drgabriellelyon.com/ Instagram: https://www.instagram.com/drgabriellelyon/ YouTube: https://www.youtube.com/@DrGabrielleLyon Order FOREVER STRONG: https://drgabriellelyon.com/forever-strong/ Order THE FOREVER STRONG PLAYBOOK: https://drgabriellelyon.com/playbook/ Want to receive my weekly newsletter? Sign up at ⁠⁠⁠⁠nataliecrawfordmd.com/newsletter⁠⁠⁠⁠ to receive updates, Q&A, special content, and freebies If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Tuesday. Plus, be sure to follow along on Instagram ⁠⁠⁠⁠@nataliecrawfordmd,⁠⁠⁠⁠ check out Natalie's YouTube channel Natalie Crawford MD⁠⁠⁠⁠, and if you're interested in becoming a patient, check out ⁠⁠⁠⁠Fora Fertility. Join the Learn at Pinnacle app ⁠to earn FREE CE Credit for listening to this episode! This episode is brought to you by The Pinnacle Podcast Network! Learn more about Pinnacle at http://learnatpinnacle.com Learn more about your ad choices. Visit megaphone.fm/adchoices