Podcasts about Parkinson

The Care Advocates is brought to you by the All Home Care Matters Media team and focuses on providing family caregivers and their loved ones with support, resources, and discussion on the issues facing them in the matrix of long-term care.   The Care Advocates are co-hosted by Lance A. Slatton & Dr. George Ackerman.   The Care Advocates are honored to welcome Anne Smith as guest to the show.   About Anne Smith: Anne Smith shines a light on the often-overlooked realities of Parkinson's disease and the profound impact it has on both those living with the condition and the family members who care for them. In this powerful conversation with Lance A. Slatton, Anne discusses the growing number of Parkinson's diagnoses, the emotional toll of watching a loved one's health decline, and the financial challenges many families face after stepping away from careers to become full-time caregivers. Her insights offer a candid look at the sacrifices, struggles, and resilience required when navigating life with Parkinson's disease.   Anne also addresses one of the most important and sensitive topics in caregiving: caregiver burnout. Drawing from her own experiences and observations within caregiver communities, she speaks openly about exhaustion, sleep deprivation, frustration, and the emotional strain that can accompany caring for a loved one with Parkinson's. This meaningful discussion serves as both an educational resource and a reminder that caregivers need support, understanding, and compassion just as much as those they care for.

To have Dr. Morse answer a question, visit: https://drmorses.tv/ask/ All of Dr. Morse's and his son's websites under one roof: https://handcrafted.health/ Facebook Page: https://www.facebook.com/handcrafted.health 00:00:00 - Intro - Diet - Spirituality 00:07:07 - Ehlers-Danlos Syndromes (EDS) - Acid Reflux - Sleep Apnea - Premature Ventricular Contractions (PVCs) - Premature Atrial Contractions (PACs) - POTS - Lax (Painful Joints) - Thoracic Outlet  syndrome (TOS) - Mast Cell Activation Syndrome (MCAS) 00:27:49 - Chronic Strep Throat 00:42:25 - AERD - Asthma - Chronic Sinusitis with Nasal Polyps - Bronchitis  - Bronchiectasis 01:08:42 - Depersonalization/Derealization - Social Anxiety - Shyness - Low Self-Esteem  01:31:27 - Parkinson's Disease - Breast Cancer - Hashimoto's Disease 00:07:07 - Ehlers-Danlos Syndromes (EDS) - Acid Reflux - Sleep Apnea - Premature Ventricular Contractions (PVCs) - Premature Atrial Contractions (PACs) - POTS - Lax (Painful Joints) - Thoracic Outlet  syndrome (TOS) - Mast Cell Activation Syndrome (MCAS) The breathing and heart issues are scary. 00:27:49 - Chronic Strep Throat After all the antibiotics, I had a really bad flare-up and struggle with fatigue. 00:42:25 - AERD - Asthma - Chronic Sinusitis with Nasal Polyps - Bronchitis  - Bronchiectasis I am currently taking steroid medications. 01:08:42 - Depersonalization/Derealization - Social Anxiety - Shyness - Low Self-Esteem  I have also experienced depression, paranoia, fear, intrusive thoughts, chronic fatigue, and irritability—the whole nine yards. 01:31:27 - Parkinson's Disease - Breast Cancer - Hashimoto's Disease I want to start your program. I didn't do chemo or radiation.

On this week's Tech Nation, Moira speaks with Dr. Cory Nicholas, Co-Founder and CEO of Neurona Therapeutics, about a breakthrough in neuroscience that leads to a new therapy showing lasting success in epilepsy. There's potential for Parkinson's, Alzheimer's, PTSD, and more.

The June 2026 Recall highlights four previously posted episodes on parkinsonian disorders. The episode begins with Dr. Valtteri Kaasinen discussing the clinical challenges of diagnosing Parkinson disease and how that diagnosis can evolve over time. The discussion continues with Dr. YuHong Fu, who addresses the importance of differentiating between dementia with Lewy bodies and Parkinson disease dementia. The third episode features Dr. Daniel Weintraub discussing clinical considerations and strategies for effective communication when addressing cognitive concerns in patients with Parkinson disease. The episode concludes with Prof. Franziska Hopfner discussing the frequency and disease trajectory of MSA patients who do not experience dysautonomia, compared with those who have autonomic involvement. Podcast links:  Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years  Dementia with Lewy Bodies and Parkinson Disease Dementia Clinical Approach to Dementia Risk in Patients with Parkinson Disease  Multiple System Atrophy Without Dysautonomia  Article links:  Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years  Dementia with Lewy bodies and Parkinson Disease Dementia — The Same or Different and is it Important?  Long-Term Dementia Risk in Parkinson Disease  Multiple System Atrophy Without Dysautonomia: An Autopsy-Confirmed Study Disclosures can be found at Neurology.org. 

Hour 3 for 6/1/26 Drew welcomes Dr. William Supple, PhD to discuss his book Cancer is a Parasite (1:00). Topics: if taking Fenbendazole can be preventative (21:35), Parkinson's (31:40), myeloma (36:27), Ivermectin (37:10), Fenbendazole (41:19), and HPV (45:14). Link: Cancer is a Parasite Book

IUL gets pitched to young professionals, families, business owners, retirees, and pretty much everyone in between. The message is always consistent: this product can solve your financial problems, provide market upside with downside protection, and generate tax-free retirement income. One product, all things to all people. For most people, IUL is the wrong tool entirely. Not because it's fraudulent. Not because it can't work for anyone. But because there's a fundamental mismatch between how it's sold and who it actually serves. And that mismatch shows up in the data.  https://youtu.be/fZS1uPmsCS0 According to a 2021 study by Gottlieb and Smetters, published in the American Economic Review (1) and drawing on SOA and LIMRA persistency data, nearly 88% of universal life policies never pay a death benefit. That figure covers all universal life products, including IUL.  And IUL was built specifically to fix the lapse problems of earlier UL products. It hasn't. The chassis is the problem. This article is a profile-by-profile look at the people who should not buy an IUL, the data that supports why, and a fair look at the narrow group for whom it might make sense. We're not taking sides. We're giving you the information you need to make a decision that actually fits your life. Key Takeaways:What IUL Actually Is, and Why the Chassis MattersThe One-Year Renewable Term ProblemWho Should Not Buy an IUL PolicyAnyone who hasn't mastered the financial basicsAnyone who needs guarantees and predictabilityAnyone practicing or planning Infinite BankingAnyone without a high, stable, long-term incomeAnyone who cannot handle the lapse riskAnyone who misunderstands what market risk means in an IULAnyone building a multi-generational legacyThe Data Nobody Shows You Before You SignThe Headline NumbersA Pattern That Keeps RepeatingTo Be Fair: Who IUL Actually ServesThe Right Buyer ProfileThe Alternative Built for the Rest of UsWhy Endowment MattersThe Reduced Paid-Up Safety NetBehavioral FitThe Decision Is Yours: Make It With the Full PictureBook a Strategy CallFrequently Asked QuestionsWho should not buy an IUL policy?Is IUL worth it for most people?What is the lapse rate for IUL policies?Who is IUL actually designed for?What is the difference between IUL and whole life for banking purposes?Can I use IUL for Infinite Banking? Key Takeaways: IUL is built on a one-year renewable term chassis, meaning internal insurance costs rise every single year as the policyholder ages Nearly 88% of universal life policies (including IUL) never pay a death benefit, with 57% of permanent policies (particularly universal life) lapsing in the first 10 years IUL cannot endow and cannot be converted to reduced paid-up status, meaning premiums are required indefinitely The product demands a level of behavioral consistency over 30 to 40 years that most people, including the most disciplined, cannot sustain IUL is not compatible with Infinite Banking because it lacks the guaranteed, predictable cash value growth the strategy requires The narrow group IUL actually serves is sophisticated, high-net-worth individuals using it specifically for estate planning leverage What IUL Actually Is, and Why the Chassis Matters Indexed universal life insurance is a form of permanent life insurance where cash value growth is linked to a market index, typically the S&P 500.  The policyholder isn't actually invested in the market. The insurance company credits growth based on index performance, subject to a cap (the maximum you can earn) and a floor (usually 0%). You participate in some of the upside. You're protected from direct index losses. That's the pitch. The One-Year Renewable Term Problem The structural reality is different from the marketing version. Unlike whole life insurance, which spreads insurance costs evenly across a lifetime so the premium never changes, IUL is built on a one-year renewable term chassis. That means the cost of insurance increases every single year as the insured ages. In the early years, you barely notice. Over decades, and especially in retirement, it becomes a serious structural pressure on the policy's cash value. The flexible premium feature, often marketed as a benefit, is part of the same structural reality. Flexibility sounds good. But it means the policy requires ongoing management and can deteriorate if premiums are reduced or skipped.  The policy doesn't just sit there working for you. It demands attention, funding, and active monitoring year after year. For a deeper look at the structural risks, internal charges, and illustration problems with IUL, see our posts on the dangerous truths about IUL risks and Todd Langford's analysis of IUL math. Who Should Not Buy an IUL Policy This is the core question. Not "is IUL good or bad?" but "is the person buying it actually a match for what the product demands?" Seven profiles. If you recognize yourself in any of them, that's information worth taking seriously. Anyone who hasn't mastered the financial basics IUL is an advanced financial product. It should not be anyone's first or second financial move. Before using a structure that combines insurance, investing, and tax planning, a person needs the basics in place: spending less than they earn, building consistent positive cash flow, and saving habitually. Parkinson's Law, the tendency for expenses to rise to meet income at every level, is real. IUL does not fix a cash flow problem. It adds complexity on top of one. If you haven't overcome the basic discipline of keeping your income above your expenses and putting the gap into savings, a complex product isn't a solution. It's a distraction from the actual problem. Anyone who needs guarantees and predictability If you need to know with certainty what your policy will be worth in 10, 20, or 30 years, IUL cannot give you that. There is no guaranteed cash value dollar amount in an IUL. The crediting depends on index performance, caps that can change annually, and internal costs that increase over time. If your financial planning requires a predictable future asset base for retirement, a major capital need, or a legacy strategy, a product built on variables is the wrong foundation. The middle class, upper middle class, and anyone with fluctuating income fall into this category. And that's most people. Anyone practicing or planning Infinite Banking IUL is actively marketed as a vehicle for Infinite Banking. It is not.  Infinite Banking requires a pool of capital that is predictable, guaranteed, and always growing. The arbitrage that makes policy loans powerful, earning in two places at once, only works when the policy's growth is reliable. In a year where the index earns zero, a policy loan doesn't just cost the loan interest. It costs the loan interest with no offsetting policy growth.  The banking system breaks down exactly when it should be working hardest. For a full breakdown, see our post on why IUL is incompatible with Infinite Banking. Anyone without a high, stable, long-term income IUL requires consistent, maximum funding over a very long time horizon to have any chance of performing as illustrated. Life disruptions like job changes, business downturns, family expenses, and medical costs interrupt premium payments. And because the policy relies on the index to help fund its own rising costs, any gap in funding creates a cascade effect that's very difficult to reverse. Even Nelson Nash, the creator of Infinite Banking, once missed funding PUAs on one of his own policies, causing the rider to close. If the creator of the strategy had trouble keeping up with premiums, the expectation that ordinary policyholders will fund an IUL perfectly for 30 to 40 years is unrealistic. Anyone who cannot handle the lapse risk Nearly 88% of universal life policies never pay a death benefit, and IUL is part of that picture. That number should stop anyone from considering this product and make them ask: why?  The answer is structural. Rising internal costs, non-guaranteed crediting, and the behavioral reality of managing a complex financial product over decades. And lapsing isn't just losing the policy. When a policy lapses with outstanding loans and cash value above the cost basis (the total premiums paid), the gain is treated as taxable ordinary income in the year of lapse. That tax bill arrives at the worst possible time, often in retirement, when income is fixed and absorbing it is most painful. Anyone who misunderstands what market risk means in an IUL Many buyers hear "zero is your floor" and believe their money is protected from losses. This is technically true and practically misleading. The 0% floor only protects against index-linked losses. It does not protect against the internal drag of rising mortality costs, administrative fees, and hedging strategy expenses, all of which continue to come out of the cash value regardless of what the index does. A zero-credit year is effectively a negative year once internal charges are factored in. And when markets perform poorly over multiple years, the insurance company's cost of maintaining those hedges rises. They respond by lowering caps. Lower caps mean less upside potential. This cycle of poor performance, higher hedge costs, and lower caps compounds over time. Anyone building a multi-generational legacy Legacy planning requires certainty across decades and generations. A policy that cannot endow, cannot be converted to reduced paid-up status, and requires active management indefinitely is not a reliable foundation for generational wealth transfer. Whole life policies endow at age 120 or 121. The cash value and death benefit converge, and the policy is contractually complete. IUL policies do not endow. Premiums are required for as long as the insured lives. There is no actuarial endpoint.  ...

From April 27 - This edition of the Regional Roundup: two people living with Parkinson's share what it's like to navigate a disease that affects more than a million Americans. We head to Norwood in southwest Colorado, where a project aims to tackle algae blooms while generating electricity. In Glenwood Springs, we hear community concerns about Flock surveillance cameras. We also visit a community choir in western Colorado that's bringing people together through music and connection. And we round out the show with a conversation on the affordable housing crisis in resort communities across the Rocky Mountain West.

Myths and misconceptions related to the surgical risks of deep brain stimulation (DBS) procedures remain common despite many years of evidence demonstrating its relative safety. This leads to both patient and provider fear in referring eligible patients for consideration of a potentially life-altering therapy for symptom management in many movement disorders. Dr. Mitra Afshari speaks to functional neurosurgeon, Dr. Chengyuan Wu, about a recent large retrospective study he conducted comparing risks of DBS surgery to other common elective surgeries. They also bring in the perspective of DBS specialist, Dr. Delaram Safarpour, who recently published expert consensus recommendations for referral of Parkinson's disease patients for DBS. Listen in on the lively discussion of how we can reframe this conversation with our patients and colleagues. Read the article.

Send us Fan MailPermits feel like “just paperwork”, until they quietly become the biggest barrier to building, investing, and even basic economic growth. We use Chile's fight with “permisologia” to show how bureaucracy creates delay, uncertainty, and political risk even when the stated goal is safety or environmental protection. • permits as transaction costs that quietly tax projects and entrepreneurship • why bureaucracy is not the same thing as government and why it crowds out market coordination • “permisologia” in Chile and how a one-stop shop becomes many counters • parallels to India's license raj and the logic of rent seeking choke points • Dominga as a case study in shifting rules, scandal, and investment held hostage • documented GDP and jobs costs from permitting delay and collapsed processing capacity • Chile's LMAS reform plan including deadlines, digitization, and sworn declarations with sanctions • Parkinson's Law, bike shedding, and why committees obsess over trivial items • listener letter on commune life and how transaction costs show up inside “one big firm” Links:What is  "Permisología"? https://comentarista.emol.com/2294117/27242033/Emol-Social-Facts.htmlFramework Law (LMAS):  https://www.bluefieldresearch.com/research/chile-takes-another-step-towards-mining-reform/Parkinson's Law and the "Law of Triviality":  https://fs.blog/parkinsons-law/Twin Oaks Community:  https://www.twinoaks.org/If you have questions or comments, or want to suggest a future topic, email the show at taitc.email@gmail.com !You can follow Mike Munger on Twitter at @mungowitz 

Live from Phoenix, Arizona, for the World Parkinson's Congress 2026; it doesn't get much better than that if you ask us. We all took turns speaking to Parkinson's experts, whether that be on dancing, singing, or even finding a cure. There's almost no one we didn't try to speak to.. We even got to hear a fantastic comedy set from Paul, of which you will get a taste. Tune in to find out what we got up to and please do join us next time in Quebec!Movers & Shakers is brought to you in partnership with Cure Parkinson's.Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Associate Producer: Lulu GoadMusic by Alex Stobbs Hosted on Acast. See acast.com/privacy for more information.

In this episode, Brian Luebben breaks down the exact framework he has used to work six months a year while building a business doing over $10 million in revenue.Brian covers:Why both corporate America and traditional entrepreneurship broke himThe two seasons every high performer needs: acceleration and navigationHow reverse goal setting and Parkinson's Law make him more productive in less timeWhat his actual calendar looks like and how he knows when to switch seasonsWhy navigation is not vacation and how to tell the differenceHow to apply this framework whether you have a nine to five, young kids, or a growing businessThis is one of the most honest conversations Brian has had about how he actually structures his life and business - and why the finish line is never coming. Curious as to how we've bought multiple businesses and built millions in equity? Give this episode a watch for a full breakdown: https://www.youtube.com/watch?v=cviipnGtDWI&feature=youtu.beIf you are serious about building a life on your terms and want to surround yourself with people who are actually doing it, go to: https://actionacademy.com?el=action_academy_podcastIf you want to leave corporate America in the next 6-18 months - you should check out our Action Academy Community

What if aging isn't inevitable — it's just your body losing the ability to repair itself? Live from the Beyond Biohacking Conference in Austin, Jason Rantz sits down with Christian Drapeau, the scientist and stem cell pioneer behind Stemregen. For nearly 30 years, Drapeau has championed a radical idea once dismissed by mainstream science: that your own stem cells are your body's natural repair system — and that releasing more of them, without injections or needles, could be the key to fighting aging and chronic disease. In this interview, Drapeau breaks down what stem cells actually do, why they decline as we age, and how endogenous stem cell mobilization differs from costly stem cell injections. He shares jaw-dropping early results from his clinical studies on congestive heart failure and Parkinson's disease, explains why academia and conventional medicine lag behind the science, and details exactly how Stemregen's plant-based approach works in the body within hours. If you care about longevity, regenerative medicine, biohacking, or simply staying healthier longer, this conversation will change how you think about your body's ability to heal itself.

The last few years handed me a stack of things I never ordered — Parkinson's, brain surgery, a pandemic, and financial pressure I've talked about openly in older episodes and on YouTube. In this brand-new, unedited, "live-to-drive" relaunch of The Ray Edwards Show, I'm not going to rehash the wounds. I'm going to do something more useful: I'm going to hand you the scars. Because the scars, as I've come to see it, are the curriculum. And what I learned in that fire has rewired everything I teach about building a business in this strange, contracting, AI-rewired moment — including why nearly every entrepreneur I meet is trying to build a personal brand in exactly the wrong order.. Here's a peek at what you'll discover when you press play: The tight little phrase I now use to describe my current state of freedom — and the brutal price I paid over the last few years to earn the right to say it. The disease: "out-of-sequentialism". You probably have it -- becuase it's quietly killing almost every coach, consultant, and creator online right now (my friend Armand Morin gave it the name) — and the embarrassingly simple test that tells you in 30 seconds whether you've got it. The Tony Robbins example about a dog and a kid named Johnny — and what it reveals about why your message isn't landing, no matter how much copy you rewrite. The dollar-store habit I credit with saving more of my best ideas than any AI tool, app, or "second brain" system ever has — and the three reasons it still humiliates your phone in 2026. (Hint: Alex Mandossian was right.) The single Bible verse I call "the entire permission slip" you need to stop hiding your gift from the marketplace — and how to read it without the religious baggage that's kept you small for years. Why "the ultimate sacrifice" wasn't REALLY the ultimate sacrifice — and the surprisingly mercenary reason Jesus did what he did, according to the Book of Hebrews. (Some pastors will not love this segment. I'm at peace with that.) The Casey Neistat number proves you don't need to be famous, funded, or follow-rich to build a business that buys back your life. (He started $200,000 in debt. With a camcorder.) The difference between Mission and Vision — confused by 95% of the entrepreneurs I've coached — and the single reason their goals never compound into anything bigger than a to-do list. The deceptively simple Destiny Formula that turns vague mission statements into something you can actually wake up and execute on Monday morning. Why "fair" does not mean "equal" — and how getting this one distinction wrong will keep you stuck in quiet resentment for the rest of your business career. The "interruptibility test" I use to decide whether a business is actually worth building — and why most "successful" entrepreneurs fail it without realizing it. A coffee shop in Spokane called Revel 77 — and the one thing it does that quietly destroys generic competitors without ever undercutting them on price. (You can steal this for any business, in any niche, this week.) Why marketing is NOT what you think it is — and the three-word definition that makes it 10x easier to do, even if you've never written a sales letter in your life. The Earl Nightingale "fireplace" line that exposes why most entrepreneurs are quietly broke. (You've made this exact mistake. Probably this week.) The reverse-engineering math that turns a $104,000 income goal into one doable, repeatable weekly task — no hype, no hustle-bro nonsense, no hopium. Why "lead magnets are dead" is one of the dumbest things being said online right now — and the value-first sequence that still prints money in 2026 (and will print more of it in 2027). The three traits every piece of marketing must have to spread on its own. The War of Art has all three. Your Best Year Ever has all three. Yours probably has one — at best. The "modern elder" our culture has discarded — and why being over 50 may be your single biggest unfair advantage in the AI era. (At 60, I'm making the case.) The four questions you must answer about your customer — in this exact order — before you write a single piece of sales copy, run a single ad, or post a single piece of content. The one phase that, when skipped, makes every other phase collapse — and the surprisingly philosophical question you must answer to nail it. (Most entrepreneurs would rather do anything than sit with this question. That's the tell.) What "destiny" actually means, etymologically — and why you can change yours today, even if today turns out to be the only day you have left. Press play. Pull out the pen and notebook I'll tell you to grab anyway. And get ready to find out exactly which phase you've been skipping.

Send us Fan MailToday on The Quivercast, we sit down with former professional surfer Mitch Parkinson @mitchparkinson. Growing up on Australia's Gold Coast, Mitch had the unique opportunity to surf one of the world's most iconic waves, Snapper Rocks, alongside some of the best surfers of his generation. From an early age, he was fiercely competitive, surfing heats for the Snapper Boardriders Club and dreaming of becoming a professional surfer. His passion for surfing was undeniable, and through dedication and hard work, he turned that dream into reality.Throughout his career, Mitch traveled the globe chasing waves and competing at the highest levels of the sport, creating memories and experiences that he still appreciates today. We talk about life after professional surfing, his current work in the mines of central Queensland, and how he continues to balance work with his love for the ocean. Even now, Mitch remains one of the standout surfers at Snapper Rocks, proving that true talent never fades. This is a great conversation about competitive surfing, life lessons, and a lifelong connection to the sport.Support the showBUY THE ENDLESS SUMMER BOX SET HERE!If you like the QuiverCast here are some ways to help us keep going!I always like Coffee!Buy me a Coffee!Find Us:Website: thequivercast.comInstagram: @quiver_castFacebook: The QuiverCastSound Editing by: The Steele Collective

In this episode,  Dr. Huda Zoghbi, Director, Duncan Neurological Research Institute at Texas Children's Hospital, Distinguished Service Professor, Baylor College of Medicine, and Investigator, Howard Hughes Medical Institute, discusses the institute's groundbreaking work in solving neurological diseases, advancing therapies for autism, epilepsy, Alzheimer's, and Parkinson's, and the power of interdisciplinary collaboration, AI, and scientific risk-taking in transforming patient care.

On this episode of Inside Startup Investing, Chris Lustrino speaks with Dr. Michael Wyand, CEO of Oxeia Biopharma, a clinical-stage biotech company developing a potential breakthrough treatment for concussions and persistent concussion symptoms. Oxeia is leveraging ghrelin, a naturally occurring hormone involved in brain energy regulation and neural repair, to help heal the inflammation and cellular damage caused by traumatic brain injuries. With promising Phase 2a data showing an 85% responder rate among treated patients, the company is pursuing what could become the first FDA-approved pharmaceutical treatment specifically targeting concussion recovery. Chris and Michael discuss the science behind concussions, how brain damage occurs after impact, why “just rest” has remained the standard of care for decades, and how Oxeia's therapy could fundamentally change the treatment landscape for athletes, veterans, and millions of patients suffering from lingering neurological symptoms. They also dive into the company's clinical pathway, the business opportunity behind concussion therapeutics, the role of neurogenesis in recovery, and the broader future potential for treating conditions like CTE, Parkinson's disease, and ALS. If you want to understand the future of concussion recovery, brain health innovation, and biotech investing, this is an episode you won't want to miss.

Dale Earnhardt Jr. sits down with longtime fixture in the NASCAR garage, Morgan Shepherd, to learn about his journey from bootlegging to becoming a multi-time Cup Series winner. Born in Ferguson, North Carolina, Shepherd followed his father Jesse Clay's footsteps into the moonshine lifestyle. It was here he honed his driving skills, and after a close call with the police scared him straight, he decided to exercise fast driving on the local short tracks. He took to the legendary Hickory Motor Speedway and began winning on a regular basis in the late model ranks. Through the 1970s, Morgan began moving up the NASCAR Late Model Sportsman rankings before winning the national crown in 1980. This accomplishment catapulted Morgan into full-time Cup competition, and before long, he would pick up his first win in the top level of stock cars, at Martinsville in 1981, driving for Cliff Stewart. Morgan drove for a litany of owners throughout his Cup career and would park cars in victory lane on four different occasions. He spent the latter part of his driving days chauffeuring rides for his own team, breaking several age-related records along the way. Morgan would make his 1000th NASCAR national start in 2018 at the tender age of 76. Morgan joins Dale Jr. for a conversation about his legendary career and his current battle with Parkinson's disease. Check out Dirty Mo Media on YouTube: https://www.youtube.com/@DirtyMoMedia Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2065: Lori Deschene explores how stress at work often comes less from the workload itself and more from the way we mentally carry it. By focusing on priorities, reducing distractions, setting boundaries, and staying present with one task at a time, she offers practical ways to create a calmer, more effective, and more intentional work life. Read along with the original article(s) here: https://tinybuddha.com/blog/10-steps-to-simplify-your-work-life/ Quotes to ponder: “Life is actually really simple, but we insist on making it complicated.” “The first step in simplifying anything starts with how we think about it.” “As long as we have to-do lists, we're going to feel tempted to try to cross things off more quickly. But this is a deceitfully complex practice.” Episode references: Dr. Amy Johnson: https://dramyjohnson.com/ Parkinson's Law: https://en.wikipedia.org/wiki/Parkinson%27s_law Learn more about your ad choices. Visit megaphone.fm/adchoices

I met Rich around 2015 when I left coaching group fitness and moved my book of business to Impact Sports Performance in Central Boca. At the time, he was the head of the facility and coach to many up-and-coming tennis superstars. Early on, we butted heads a bit as we were both early risers, and he was used to being one of the only people in the gym at that hour.What started as tension eventually turned into a genuine respect for each other's work ethic, business mindset, and the effort it took to show up every single day. We worked alongside each other for several years, sharing that huge training space and watching countless athletes and coaches come and go. When I eventually opened my own facility, Rich couldn't have been more supportive.We stayed connected through social media, and one day while watching the US Open, the broadcast cut to the athletes' training box. Sitting there stoically, locked into the match, was Rich. His athlete was battling for a spot in the finals. I snapped a photo and sent it to him with a quick message: “Congrats, man. So cool to see.” A few hours later he replied briefly as they were still on the road chasing a championship.Over the years, I continued asking him to come on the show, but it never quite materialized. Then, a couple months into 2026, he released a public video sharing his diagnosis with Parkinson's disease. I watched the video several times and reached out to offer my support and appreciation for his honesty and vulnerability. Not long after, he agreed to come on the show.He explained that for years he simply wasn't ready to sit down and openly talk about coaching, sports, or life because he was privately carrying the weight of the diagnosis while trying to hide it from the world. It was exhausting. When he arrived for the interview, he was completely himself. We sat down, went over the usual guidelines; open book, nothing off limits and started talking. He shared incredible stories from years of coaching at the highest international levels of tennis and reflected on the experiences and pressures that came with it. Most importantly, he opened up honestly about living with Parkinson's. His physical challenges, the emotional toll and the journey toward acceptance. It became one of the most heartfelt, honest, and vulnerable conversations I've had on the show and I truly hope you enjoy listening to it as much as I enjoyed having it.

Learn more about Parkinson's and find support: https://dpf.org In part three of this three-part series on Parkinson's and the senses, the panel covers vision changes like difficulty driving at night, light sensitivity, depth perception, and how DBS adjustments can affect focus. They also discuss vertigo, dizziness, and the urinary urgency that many people with Parkinson's experience but rarely talk about, including practical strategies like pre-boarding flights and planning bathroom access. Sign up for updates on webinars, events, and resources for the Parkinson's community: https://dpf.org/newsletter-signup  Season 7 Episode 8 Davis Phinney Foundation, Copyright 2026

What if the answer to energy, metabolism, inflammation, brain health, and longevity isn't another diet — but your microbiome? In this episode of The Sisterhood of S.W.E.A.T., Linda sits down with microbiome researcher Martha Carlin to discuss the fascinating science connecting gut health, metabolic flexibility, inflammation, circadian rhythms, and chronic disease prevention. You'll discover: • Why identical diets create different results • The connection between gut health and blood sugar regulation • How toxins disrupt microbial balance • The role microbes play in energy and metabolism • What endotoxins are and why they matter • The gut-brain connection and cognitive health • Practical ways to support your microbiome naturally If you've ever felt like you're doing everything right but still struggling to feel your best — this episode may change how you think about health forever. For more episodes, subscribe to The Sisterhood of S.W.E.A.T. Summary In this episode, Martha Carlin shares her transformative journey into microbiome science, exploring how gut health impacts chronic disease, longevity, and overall wellness. Discover the latest insights on microbiome restoration, personalized nutrition, and innovative therapies like probiotics and fecal transplants. Keywords microbiome, gut health, chronic disease, longevity, probiotics, endotoxins, microbiome therapy, Parkinson's, microbial balance, personalized wellness Key Topics Microbiome and human health Impact of diet and environment on gut microbes Innovative therapies for Parkinson's and chronic diseases Sound Bites "Health is bigger than calories and quick fixes." "Restoring microbial balance can transform health." "Natural solutions can be more effective than drugs." Chapters 00:00 Introduction to Martha Carlin and Microbiome Science 02:38 Personal Journey into Microbiome Research 04:22 Understanding the Terrain and Ecosystem of the Human Body 05:42 Why the Microbiome Matters More Than Human Cells 07:04 Microbiome and Chronic Disease Connections 08:07 Martha's Work on Parkinson's and Microbial Interventions 10:12 The Role of Specific Bacteria in Disease and Health 12:06 Probiotics and Microbial Strains for Health Optimization 14:35 Substrains and Clinical Evidence in Probiotic Use 17:29 Microbiome and Blood Sugar Responses 19:33 Impact of Stress and Sleep on the Microbiome 21:26 Practical Tips for Resetting Circadian Rhythms 37:35 Starting Point for Improving Gut Health 38:47 Water Quality and Mineral Replenishment 40:05 The Future of Microbiome and Fecal Transplants 45:11 Podcast Outro.mp3

What if the key to healing trauma isn't in the story you tell, but in the sensations you feel?Dr. Brian Tierney talks with Robert Weiss, PhD—a retired psychologist with 52 years of clinical experience and the developer of Mindfulness-Based Somatic Emotional Processing (MBSEP). Born in Lima to German Jewish Holocaust survivors, Weiss shares how his own early trauma shaped a career that evolved from behavioral training into Ericksonian hypnosis, EMDR, brainspotting, and finally MBSEP. He explains why mindful attention to bodily sensations often heals more deeply than narrative or meaning-making, and how breath, resourcing, and therapeutic relationship can address dysregulation and fragmentation. Through powerful case examples—intergenerational grief, workplace anger, childbirth loss, and even his own Parkinson's diagnosis—Weisz illuminates what it truly means to move into fear and transform through the body.Highlights:- How early trauma as a child of Holocaust survivors shaped Weiss's clinical path- Why MBSEP focuses on sensation over storyUsing breath and "scene work" for regulation and resourcing- How Ericksonian hypnosis built the foundation for relational safety- Intergenerational trauma and the therapeutic use of numinous imagery- Working with anger, shame, guilt, and mixed emotions- Moving into fear as a practice—including Weiss's own journey with Parkinson's- Ayahuasca, love as transformation, and the limits of "McMindfulness"Guest: Robert Weiss, PhD https://mbsep.com/about/robert-weisz-phd/https://www.simonandschuster.com/authors/Robert-Weisz/248111300Host: Dr. Brian Tierney www.somaticdoctor.comWe want to hear from YOU:What resonated most with you—the intergenerational case example, working with anger, or Weiss's perspective on moving into fear with Parkinson's? Let us know in the comments below.-------------------------------------------------------Hashtags:#TraumaHealing #SomaticTherapy #MBSEP #BoundlessBodyPodcast #RobertWeiss #Mindfulness #Hypnotherapy #EricksonianHypnosis #IntergenerationalTrauma #ParkinsonsAwareness #EmotionalProcessing #SomaticExperiencing #IFS #Brainspotting #EMDR

Send us Fan MailIn this episode of the Quantum Health Connection Podcast, Heather and Vanessa explore the fascinating science and emerging quantum biology of melanin, and why it's so much more than skin pigment.Melanin is often thought of only in terms of tanning or skin color, but it is actually a deeply intelligent biological system that helps regulate light, protect against oxidative stress, support the nervous system, and potentially even influence cellular energy production.Vanessa shares her recent experience in St. Lucia, where she successfully built solar adaptation and spent time in intense tropical sun without burning, highlighting the power of gradually building melanin through intentional UVA and UVB exposure rather than relying solely on sunscreen and sun avoidance.In this conversation, we discuss:☀️ Why melanin is much more than skin pigment: it acts as a light regulator; antioxidant; and biological semiconductor ☀️ The difference between UVA and UVB light, and why UVA is essential for melanin production and solar adaptation ☀️ How gradual, strategic sun exposure helps your body build its own natural protection ☀️ Why modern indoor living, excessive sunscreen use, and artificial light disrupt healthy melanin production ☀️ The difference between eumelanin and pheomelanin, and how your melanin type influences sun tolerance ☀️ Melanin's role in the brain, eyes, gut, and immune system ☀️ Emerging research on melanin's potential role in energy production and quantum biology ☀️ How melanin may help bind heavy metals and protect against neurodegeneration, including conditions like Parkinson's disease ☀️ The connection between sunlight, melanin, improved food tolerance, vision, and nervous system resilience ☀️ Why balance vs fear is the key to developing a healthy relationship with the sunWe also discuss cultural attitudes around tanning and sun avoidance, the importance of respecting your individual solar capacity, and how reconnecting with natural light may be one of the most overlooked foundations of health.Melanin is not just pigment. It is part of your body's built-in solar intelligence that helps you interact with light, energy, and the environment in ways we are only beginning to understand.Learn how to partner with the sun, so your body can remember how to thrive!For more about melanin, blue blockers, quantum biology, and light-based healing, follow Vanessa's substack:.https://substack.com/@brightlightwellnessVanessa's Get Your Light Right Masterclass & Ebook:https://payhip.com/b/T9h1xSupport the showFind Heather:Book with HeatherHeather's Free Product Guide with Discount CodesHeather's Instagram Find Vanessa:Vanessa's Instagram Vanessa's Website Free Product Guide with Discount CodesFree Homeopathy at Home Guide 

This is a special crossover episode with Made For Us, a podcast that explores the intersection of innovation and inclusion. On Made For Us, host Tosin Sulaiman speaks to founders, designers and business leaders who are thinking deeply and creatively about how to build better and more inclusive products. Tosin's guest on this episode is Maura Horton, CEO and founder of MagnaReady, an accessible fashion brand that enables millions of people with limited dexterity and mobility to dress independently. Maura developed the concept for MagnaReady after her husband was diagnosed with Parkinson's and struggled to button his shirts. She invented and eventually patented a magnetic closure system that replaces buttons and has since licensed the technology to Fortune 500 Companies including PVH Corp, owner of Calvin Klein and Tommy Hilfiger. Maura also partnered with and advised Tommy Hilfiger Adaptive, the first mainstream brand to launch a children's adaptive apparel line. In this episode, Maura talks about: The state of the adaptive clothing market before MagnaReady How Maura got the inspiration to infuse magnets into her husband's shirts The challenges she faced in the design and manufacturing process Why Maura thinks the term 'adaptive' is unhelpful Learn more about MagnaReady at magnaready.com and @magnaready on Instagram. Listen to other episodes of Made For Us: podfollow.com/made-for-us/view Follow Made For Us on social media: LinkedIn: linkedin.com/company/madeforuspodcast  Instagram: instagram.com/madeforuspodcast  Support or sponsor Beyond 6 Seconds: BuyMeACoffee.com/Beyond6Seconds Read the episode transcript: carolynkiel.com/podcast/accessible-fashion-maura-horton-magnaready Follow the Beyond 6 Seconds podcast in your favorite podcast player: pod.link/1336740192  Subscribe to the FREE Beyond 6 Seconds newsletter for early access to new episodes: mailchi.mp/f9f6e8356138/insider  Disclaimer: The views, guidance, opinions, and thoughts expressed in Beyond 6 Seconds episodes are solely mine and/or those of my guests, and do not necessarily represent those of my employer or other organizations. These episodes are for informational purposes only and do not substitute for professional medical advice. Consult a medical professional or healthcare provider if you are seeking medical advice, diagnoses, or treatment. 

In this empowering episode of the Be Fabbo Podcast, host Bobbi Brinkman explores the pivotal role your lived experiences play in building trust and creating real connections in both business and life. Whether you're just starting, rebuilding, or looking to grow, Bobbi shares personal stories of overcoming learning differences, embracing imperfection, and navigating life and business with authenticity—including the challenges and triumphs of living with Parkinson's.Discover why your journey, setbacks, and comebacks matter far more than credentials or “social proof,” and learn how your unique story can inspire and help others move past their own obstacles. This episode is packed with motivational insights and practical questions to help you recognize and value the expertise you already hold, encouraging you to show up as your authentic self and share your truth—building genuine trust and impact along the way.Perfect for entrepreneurs, business owners, coaches, creatives, and anyone craving more meaning and momentum in their journey. Don't miss Bobbi's actionable advice on embracing imperfection, sharing your story, and transforming lived experiences into powerful business assets.For more resources and deeper dives into building with what you've lived, be sure to check the show notes and join the Motivated To Be Fabbo community on Substack!Let's keep the FABBO convo going, send me a text!Support the showThank you for being a FABBO listener and supporting the Be Fabbo Podcast

In this episode, hosts Erin Gallardo, PT, DPT, NCS and Claire McLean, PT, DPT, NCS and JJ Mowder-Tinney, PT, PhD, NCS discuss the critical but under-addressed role of transitional movements in neurologic rehab, especially for people with conditions like MS, Parkinson's disease, stroke, and spinal cord injury. In the show we'll highlight how traditional therapy often focuses on sitting, standing, and walking, while many real-life challenges involve moving through positions such as supine, prone, quadruped, kneeling, and floor-to-stand. Claire and JJ share clinical experiences showing that training mobility in these varied positions can transform posture, confidence, bed mobility, fall recovery, and functional independence, even when research and standardized assessments lag behind. We also emphasize the need for objective, time- or repetition-based measures of transitions, discuss safety and buy-in for both therapists and patients, and note how clinicians may be able to use more creative, high-skill interventions. We'll talk you through what a session could look like taking a patient through the transitional movements you want to train them in and why it matters. For more education on this - and a visual - join us for a free webinar on June 2nd!  Register here: https://us02web.zoom.us/j/86927822993 To get mentorship and continuing education on the latest evidence-based techniques you can apply immediately, join NeuroSpark! Learn more at www.joinneurospark.com

Show Notes: Peter Schmidt talks about his senior year during the Iraq War, and how the news on the problem of jobless recovery led him to consider graduate school.  The Journey from Student to Dean Peter studied biomechanics at Cornell, focusing on the mathematics of biological systems and modeling clinical trials in orthopedics. He was admitted into  a fellowship program in New York at an orthopedic  hospital where he worked on total joint replacement.  His career path led him to neuroscience, where he led clinical research and worked for a nonprofit before becoming the vice dean of a medical school. He then moved on to running clinical trials and drug development.  A Focus on Parkinson's Disease Pete shares his interest in Parkinson's disease and explains that Parkinson's affects a tractable part of the brain, the basal ganglia, which is easier to model mathematically. He enjoys thinking about neuronal signaling and the microstructure of the brain, which helps in understanding the macro structure. Pete's PhD work involved modeling bone at the cellular level, and he applies similar thinking to the basal ganglia in Parkinson's disease. Research on Neurodegenerative Diseases Pete discusses the challenges in determining whether a question in neurodegenerative diseases is a question of science or engineering. He explains the historical focus on stem cells and extracellular proteins as solutions for diseases like Alzheimer's and Parkinson's. Pete emphasizes the need to understand the role of extracellular proteins and the importance of scientific inquiry. He mentions the Nobel Prize-winning discovery of prion diseases and the subsequent focus on characteristic proteins in neurodegenerative diseases, which led to initiatives focused on proteins.  The Brain's Micro and Macro Structures Pete discusses the current focus on extracellular proteins and the challenges in proving their role in diseases like Parkinson's. He mentions the drug Lecanemab for Alzheimer's, which slows the disease but does not reverse it. Pete predicts that future research will focus on intracellular proteins and the need to restore lost cells in the brain. He highlights the importance of understanding the microstructure to inform the macro structure of the brain. The Logistics of Running Clinical Trials Pete explains that success in clinical trials is more about logistics than science, with 90-95% of the work being logistical. He discusses the challenges of recruiting subjects and the importance of working with academic medical centers that have a high volume of patients. Pete emphasizes the need for fast-moving ethics boards and efficient contracting to ensure the success of clinical trials. Incentives for Physicians When asked about the incentives for physicians to participate in clinical trials, Pete explains that most physicians are driven by scientific interest rather than financial incentives. He mentions the importance of academic leaders who can influence the participation of residents and fellows in trials. Pete highlights the passion of physicians in diseases like Huntington's and cystic fibrosis, which drives their engagement in research. The Role of Pharma Companies in Clinical Trials Pete talks about his role at East Carolina University where he oversaw clinical care and research at the medical school. He discusses the changing role of pharma companies in running clinical trials. He explains that many drugs are now discovered in labs, leading to a shift in the need for pharma companies to own their data. Pete mentions the issue of trial fraud, where fake patients are used to inflate data, and the importance of tighter control over trial data. He shares his experience of rescuing a trial from fraudulent data and the challenges of identifying such issues. Life on the Family Farm The conversation turns to Pete's family life, and Pete shares that his youngest child recently went to college, and he inherited a family farm that has been in his wife's family for 200 years. He enjoys working with his hands, doing woodworking, and using a skid steer for various tasks on the farm. Pete describes his role as the farm handyman, fixing things and maintaining the farm equipment. Harvard Reflections Pete mentions taking a quantum mechanics course and a material science class with X-ray interferometry. He highlights the impact of a physics class on fits and tolerances, which taught him about the importance of clearance and interference fits. Pete also shares his experience taking a folklore course with his roommate, which was his only pass/fail course at Harvard.  Pete explains the concept of fits and tolerances in engineering. He discusses the importance of understanding whether a fit needs to be tight or loose and planning accordingly. Pete uses examples from finance to illustrate the principle of having a cushion in budgeting. He emphasizes the need to know the target fit (tight or loose) to optimize engineering and design solutions. This episode on The 92 Report:https://92report.com/podcast/168-peter-schmidt-from-math-to-neuroscience/ Timestamps: 02:40: A focus on Parkinson's Disease  05:10: Challenges in Neurodegenerative Disease Research 09:50: The Role of Extracellular Proteins and Future Directions  17:34: Running Clinical Trials and Logistics  27:58: Incentives for Physicians to Participate in Clinical Trials  32:16: Pharma Companies and Clinical Trial Data  38:53: Personal Life and Farming  42:30: Reflections on Harvard Courses 46:23: Fits and Tolerances in Engineering  Links: https://www.linkedin.com/in/pnschmidt https://www.instagram.com/pnschmidt  

The hardest losses aren't always the obvious ones. Sometimes it's the moment you realize you might never ride again, never rebuild the full set of tools you spent decades collecting, or never feel as fearless in your body as you once did. Travis opens up about a brutal stretch of life with Parkinson's disease, the aftermath of a house fire, and how a DBS battery failure can spark a terrifying thought: is this a snapshot of my future? We talk about grief and mourning as something that can hit in “moments” that start coming closer together. We get into the identity question that sits underneath it all: if you stop climbing, riding, training, or creating the way you used to, are you still the same person? Judy shares her own version of letting go, from bikes that sit unused to the emotional weight of items you keep because they hold a previous self. We also unpack the real-world pressure of limited resources like money, time, and energy, and how those limits can make grief feel sharper. We don't offer a neat fix, because sometimes there isn't one. What we do offer is language for the experience, permission to be “okay with not being okay,” and a path back toward acceptance without surrender. If you're living with chronic illness, caregiving, Parkinson's, or major life change, this conversation is for you. Subscribe, share with a friend who needs it, and leave a review telling us what helps you stay present when the future feels heavy.Co-hosts: Judy Yaras & Travis Robinsonwww.INDYpodcast.net

Bloody hell… this one smacked me right in the chops. Stephen Jenkinson (my favourite guest, just quietly) is back on the show and this conversation was nothing like the others… and somehow also exactly like the others. We talked about Parkinson’s, terror, identity, regret, suffering, joy, and what happens when the bloke who helps people understand death and life gets blindsided by his own brutal reality. There were moments in this chat where I genuinely forgot to breathe. Stephen spoke about the collapse of certainty, the illusion of control, the strange grief of losing parts of yourself while still being alive… and whether we’re actually supposed to remain the same person forever. We got into regret, awe, suffering, old wounds, childhood survival, dancing with trembling hands, and the active pursuit of joy. Not happiness. Not comfort... Joy. This isn’t a neat conversation with tidy answers. It’s raw, confronting, beautiful, deeply human… and as it always is with Stephen, it's honestly one of the most important chats I’ve had. Enjoy, legends. SPONSORED BY TESTART FAMILY LAWYERS Website: testartfamilylawyers.com.au STEPHEN JENKINSON Website: orphanwisdom.com/ TIFFANEE COOK Linktree: linktr.ee/rollwiththepunches Website: tiffcook.comSee omnystudio.com/listener for privacy information.

We're at the RHS Chelsea Flower Show! This year's event has a special focus on Parkinson's with the newly named Parkinson's Resilience Rose and the beautifully designed Parkinson's UK show garden. Unsurprisingly, the weather chose to be less than impressive for the day of our visit, but that didn't stop us from enjoying the sites and exploring the PUK plot with the help of the Head Gardeners and charity team. We spoke to a great range of plant experts and show attendees to find out what they thought about this significant year for PD at Chelsea.Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Associate Producer: Lulu GoadMusic by Alex Stobbs. Hosted on Acast. See acast.com/privacy for more information.

Highlights from the RHS Chelsea Flower Show 2026 with David Maxwell, featuring the gold medal-winning Trussell's Together Garden — the first Chelsea garden to be relocated to Northern Ireland. David meets women from the Strabane Community Project, where the garden will soon be rebuilt, and its designer, Rob Hardy. He also speaks to Arit Anderson about her show garden for Parkinson's UK and meets The Traitors star Rachel Duffy, whose late mum lived with the condition. As usual, David catches up with Joanna Lumley and other famous faces, including Sophie Raworth, Timothy Spall, Dame Judi Dench, Alan Titchmarsh, Rob Brydon and Nigel Slater. Inside the Great Pavilion, plant experts offer advice on roses, alstroemerias and vegetables, while David also visits Sarah Eberle's award-winning garden, On the Edge, which encourages us to garden with nature in mind.

A new treatment for those suffering from PTSD. The "gold-standard" treatments for Parkinson's disease may be working against each other. Do tv commercials actually work? The impact of being in a romantic relationship with a narcissist. Facebook: ingoodhealthpodX: @ ingoodhealthpodIG: @ingoodhealthpodYouTube: @ingoodhealthpodSpotify Apple Podcast In Good Health PodcastSubscribed to the newsletterFull ArchiveContact UsBecome an Affiliate Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Brent speaks with Dr. David Hafler, a pioneering neurologist and immunologist whose research helped establish multiple sclerosis as an autoimmune disease and reshape how it's treated today. Drawing on decades of work at both Harvard and Yale, Dr. Hafler explains the emerging evidence connecting Epstein-Barr virus to MS, why certain genetic profiles may leave people unable to fully clear the virus, and how early intervention has transformed outcomes for many patients. The conversation also covers how inflammation works, why autoimmune diseases may be an evolutionary tradeoff, and what researchers are beginning to uncover about the links between the gut, brain, and neurodegenerative disease. They also explore the surprising role of salt in inflammatory responses, the promise of new Parkinson's prevention trials, and why Hafler believes we may be entering a golden age of medical science. He's a wonderful guest, hope you enjoy.

Chelsea is upon us, and among the beauty of all the show gardens lies a very special offering from Arit Anderson and Parkinson's UK.She's planting with purpose in a garden which promises to reflect every Parkinson's journey in a beautifully poignant way, and on ‘grow, cook, eat, arrange', she walks us through the planting ethos and careful design behind one of Main Avenue's great sights for 2026.In this episode, discover:How Arit is reflecting her sister Julie's Parkinson's journey in a meaningful Chelsea Flower Show garden for Parkinson's UKWhat Parkinson's really is beyond the stereotypes, and why it's so often misunderstoodHow thoughtful garden design can respond to real medical challengesPractical ideas for making any garden more accessible, sensory and restorative, whether or not you're living with Parkinson'sThe garden's relocation to the John Radcliffe Hospital, and how it will serve the Parkinson's community long after ChelseaProducts mentioned:Digitalis purpurea ‘Alba' (White Foxglove): sarahraven.com/products/digitalis-purpurea-albaSee our events: https://www.sarahraven.com/courses-eventsGet in touch: info@sarahraven.comShop on the Sarah Raven Website: https://www.sarahraven.com/Follow us on Instagram: https://www.instagram.com/sarahravensgarden/Follow Sarah: https://www.instagram.com/sarahravenperchhill/Order Sarah's latest books: https://www.sarahraven.com/gifts/gardening-books?sort=newest

In this episode, editor in chief Joseph E. Safdieh, MD, FAAN, highlights articles about a new selective dopamine agonist for people with Parkinson's disease, the use of artificial intelligence in preparing journal manuscripts, and caffeinated coffee's role in reducing dementia risk.

The herbicide paraquat is so toxic it's banned in over 70 countries. But its use in the U.S. is growing, despite known links to Parkinson's disease. In southeastern Mississippi, an industrial plant is leaking tens of thousands of pounds of the chemical into the air. Environmental reporter Delaney Nolan and epidemiologist Beate Ritz join Host Flora Lichtman to discuss the implications of this leak, and what we know about how paraquat affects the body. Guests:  Delaney Nolan is an environmental reporter based in New Orleans. She reported this story for The Lens and the Mississippi River Basin Ag & Water Desk. Dr. Beate Ritz is a professor of epidemiology at UCLA in Los Angeles. Other episodes you may enjoy: Teasing Apart The Causes And Early Signs Of Parkinson's Workout Worms May Reveal New Parkinson's Treatments Want SciFri gear? Check out our new shop! Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-4-SCIFRI Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Learn more about Parkinson's and find support: https://dpf.org In part two of this three-part series on Parkinson's and the senses, the panel discusses how Parkinson's affects hearing, touch, and the ability to handle busy environments. They cover brain processing sound slower, overstimulation in noisy and crowded places, proprioception and not knowing where your body is in space, the challenge of touchscreens and keypads, and how loss of dexterity has directly impacted their careers. Sign up for updates on webinars, events, and resources for the Parkinson's community: https://dpf.org/newsletter-signup  Season 7 Episode 7 Davis Phinney Foundation, Copyright 2026

Dr. Deb Muth 00:04What if the future of healing isn’t about replacing cells, but about teaching your body how to heal itself again? We keep hearing the words stem cells and exoomes thrown around like they’re interchangeable, but they’re not. One is regulated, controversial, and often misunderstood. The other is rapidly emerging as one of the most exciting communication systems in human biology. Dr. Deb Muth 00:33And here’s the real question no one’s asking. Are we actually regenerating tissue or are we just stimulating the body to remember how it used to heal? Tired of being told your labs are normal, but you still feel terrible? At Serenity Healthcare Center, we don’t chase symptoms. We find the root cause. hormones, gut health, autoimmune conditions, chronic fatigue, brain fog. Dr. Deb Muth 01:02We use cuttingedge functional and regenerative medicine to get you real answers and a real path forward. This isn’t your average doctor’s office. This is medicine the way it was meant to be practiced. You deserve to feel like yourself again. Visit serenityhealthcarecenter.com to book your appointment today. Let us help you heal from the inside out. Dr. Deb Muth 01:28Welcome back to Let’s Talk Wellness Now. I’m Dr. Deb, your host. And if you’ve been following regenerative medicine, you’ve probably noticed the confusion. Patients are asking me every week, are exoomes stem cells? Are stem cells legal in the United States? I heard the FDA is shutting down all these clinics. Can I even get this therapy? Do I have to leave the country for treatment? Today, we’re cutting through the noise. This episode is not hype. Dr. Deb Muth 01:54It’s not sales. It’s education so you can understand the science, the regulatory reality, and the clinical difference between stem cell therapy and exoome therapy. And here’s what I want you to know right up front. Yes, these therapies are being used in the United States every single day. Yes, they’re being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 02:22Some are being used in FDA registered clinical trials. Some are being used in observational studies and some are being used in clinical practice under physician discretion. The landscape is nuanced and you deserve to understand it. So, grab your cup of coffee or tea and settle in for a deep dive into the most understood therapies in regenerative medicine. Dr. Deb Muth 02:43what they actually are, how they work, the regulatory landscape, and how they might support your body’s natural healing capacity. Let’s talk wellness now. So, let me start by asking you something. When you hear the word stem cell, what do you picture? Most people imagine damaged tissues magically regenerating or a torn meniscus growing back, cartilage reforming it into an arthritic joint or damaged brain tissue being replaced with healthy new beautiful cells. It’s a beautiful vision. Dr. Deb Muth 03:15And while it’s not quite that simple, the reality is actually more sophisticated and honestly more beautiful. Stem cells are powerful and they absolutely work, but the way they work and the mechanism by which they support healing is far more elegant and more so than most people really understand. And if you’re going to invest in regenerative therapy, you deserve to understand what you’re actually receiving. Dr. Deb Muth 03:44So, let’s start at the beginning. What are stem cells? At their core, stem cells are undifferentiated cells. That means they haven’t yet decided what they want to be when they grow up. Unlike a heart cell or a skin cell or a bone cell which have already committed to a specific function, stem cells exist in this beautiful state of potential. Dr. Deb Muth 04:05They have two remarkable abilities. First, they can self-renew. They can make copies of themselves, maintaining a reserve of these powerful cells throughout your lifetime. Second, they can differentiate under the right conditions. They can transform into specialized cell types. Bone cells, cartilage cells, nerve cells, muscle cells, even blood cells. Dr. Deb Muth 04:27This is why they’ve captured the imagination of the medical world. The potential is extraordinary. Now, there are several types of stem cells and understanding the differences matters tremendously for both understanding how they work and understanding how they’re regulated. Adult mezzenymal stem cells. We call these MSC’s are the most commonly used regenerative medicine. Dr. Deb Muth 04:54These come from bone marrow, atapost tissue, that’s fat, and other adult sources. They’re what we can call multi-potent, meaning they can become several types of cells, but not every type. A bone marrow stem cell isn’t going to become a brain cell, for instance. It has potential but it’s directed potential. Dr. Deb Muth 05:19Then we have perinatal stem cells. These come from umbilical cord blood cord tissue or something called Wharton’s jelly which is the gelatinous substance inside the umbilical cord. These cells are younger, more potent, and research by Weiss and colleagues published in stem cells back in 2006 showed that Wharton’s jelly derived MSC’s have superior proliferation and differentiation potential compared to bone marrow derived cells. Dr. Deb Muth 05:48They’re like comparing a 20-year-old athlete to a 50-year-old athlete. Both can perform, but one has more reserve capacity, more vigor, and more regenerative potential. And this isn’t this is very important because the perinatal sources umbilical cord tissue Wharton’s jelly amniotic tissue these are what many regenerative medicine clinics in the United States are using today and they’re using them because these tissues are incredibly rich in not just stem cells but growth factors cytoines and exoomes. Dr. Deb Muth 06:21Then there are embryionic stem cells. These are pur potent and they become any cell type in the body, but they’re highly regulated, ethically controversial, and honestly, they’re not being used in clinical practice in the United States outside of the very specific FDA approved research trials. Dr. Deb Muth 06:41So, when clinics talk about stem cell therapy, they’re almost never talking about embryionic stem cells. Now, here’s where it gets interesting and this is the part that changes everything about how we understand regenerative medicine. When you receive stem cell therapy, let’s say someone injects umbilical cord derived messenymal stem cells into your arthritic knee, those cells do not typically engraft or become new tissue in any permanent way. Dr. Deb Muth 07:12They don’t set up shop in your joint and start cracking out new cartilage cells for the rest of your life. So what are they actually doing then? Well, in 2011, researchers Arnold Arnold Kaplan and Dennis Korea published a landmark paper in stem cells translational medicine that fundamentally changed how we understand MSC therapy. Dr. Deb Muth 07:35They proposed that we should stop calling memal stem cells and start calling them medicinal signaling cells. Why? Well, because their primary therapeutic benefit doesn’t come from what they become. It comes from what they secrete. Think of stem cells as incredibly sophisticated biological pharmacies. When you inject them into damaged tissue, that arthritic knee, that inflamed autoimmune condition, that injured brain, that don’t just sit there passively, they sense the environment. Dr. Deb Muth 08:07They detect inflammation. They recognize the tissue damage and they understand that the immune dysregulation is present and they see that and respond. They start pumping out hundreds of bioactive molecules, growth factors that tell your cells to repair and rebuild, cytoines that modulate inflammation, chemocines that recruit your body’s own healing cells to the area. Dr. Deb Muth 08:32And these tiny membranes bound packages called extracellular vesicles, including exosomes, which we’re going to talk about extensively today as well. These secreted factors are giving instructions to your native cells. They’re saying, “Let’s reduce inflammation. Let’s modulate your immune response. Let’s promote angioenesis. Dr. Deb Muth 08:53” That’s the formation of new blood vessels, bringing nutrients and oxygen. Let’s stimulate your own resident stem cells to wake up and get to work. Reduce cell death in damaged tissue and restore normal cellular function. This is called paracrine signaling. It’s the cellto cell communication. And this is where the real therapeutic power lives. Dr. Deb Muth 09:14The stem cells themselves, many of them die within days to weeks, but the cascade of healing they trigger, the signals they send, the programs they activate in your own cells, those effects can last for months or even years. Now, this understanding is crucial because it explains why both stem cell therapy and exoo therapy can be effective. Dr. Deb Muth 09:38The stem cells are powerful not because they become new tissue but because of the signals they send and exoomes are those signals isolated and concentrated. The biggest misconception in regenerative medicine is that stem cells replace tissue and in reality they coach healing more than they become healing. They’re biological educators teaching your body to remember how it used to heal before chronic inflammation, toxicity, and disease turned off all those programs. Dr. Deb Muth 10:12So if stem cells don’t exactly end graft and become the new tissue, if their power is in their signaling and then next logical question is why do we need the cells at all? Well, if we could isolate the messengers themselves, what if we could deliver just the communication systems without any of the complexity of the living cells? Well, that’s exactly what exosomes are. Dr. Deb Muth 10:38And they represent the cutting edge of regenerative medicine. So, let me paint you a picture of how cells actually communicate. Because for most medical history, we had it wrong. For decades, textbooks taught us that cells talk to each other in two basic ways. through direct contact like shaking hands or releasing signaling molecules that floated through the extracellular space like messages in bottles, simple chemical messages. Dr. Deb Muth 11:09But in the 1980s and 90s, researchers started discovering something far more sophisticated. cells were releasing these tiny membrane bound packages like a biological FedEx envelope kind of you know it was filled with complex specific cargo and these packages could travel through the blood cross the barriers that normally keep things out like bloodb brain barrier and deliver their contents to distant cells with remarkable precision. Dr. Deb Muth 11:38These are called extracellular vesicles. And exoomes are one of the most therapeutic important types. So what exactly are exosomes? Well, they’re nanosized vesicles, typically 30 to 150 nanome in diameter. To put that into perspective, a human hair is about 100,000 nanometers wide. These are incredible and most impossibly tiny. Dr. Deb Muth 12:09They’re released by virtually all cells in the body, but the most therapeutically interesting exoomes come from mezenymal stem cells. And those medicinal signaling cells we just discussed. And according to a landmark review of Raposo and Stervogal, they published in the journal of cell biology in 2013, exoomes are not cellular debris. They’re not waste products. Dr. Deb Muth 12:35They are precisely engineered communication vesicles or vehicles. Think of them as sophisticated delivery systems carefully packed, carefully labeled, and sent to specific destinations. very specific instructions. Inside each of these exoomes, you’ll find an incredibly sophisticated payload. They are microRNAs. These are small RNA molecules that can literally turn genes off or on in the recipient cells. Dr. Deb Muth 13:06They can tell a cell to start making more collagen, to reduce inflammatory proteins, to activate repair programs that have been shut down by chronic disease for a very long time. There are messenger RNAs, actual templates for protein production. And exoome can deliver these instructions for making healing proteins. There are proteins themselves, growth factors, cytoines, enzymes, all the molecular tools a cell needs to heal. Dr. Deb Muth 13:34And there are lipids, specialized fats that help the exoome membrane fuse with targeted cells, delivering the cargo inside. When an exoome reaches its target cell, it can either fuse the cell membrane and deliver its contents directly inside like a Trojan horse, or it can bind to surface receptors and trigger signaling cascades, setting off a chain reaction of healing responses. Dr. Deb Muth 14:01Either way, it’s delivering very specific targeted instruction. And here’s what makes this so powerful. Those instructions are tailored to what this recipient cell actually needs. So, let me give you some concrete examples of what the research actually shows because this is where it really gets exciting. When researchers inject MSC derived exoomes into hearts that had experienced eskeeia, reprofusion, injury, that’s damaged blood flow being cut off and then being restored. Dr. Deb Muth 14:36Kind of like what happens during a heart attack. Something remarkable happened. A study by Lei and colleagues published in stem cell research in 2010 showed that exoomes significantly reduced the size of the damaged area, reduced inflammatory cytoines that drive tissue destruction and promoted tissue repair signaling. The exoomes were telling the heart cells stop the inflammatory cascade, activate your survival programs and repair the damage. Dr. Deb Muth 15:06In cartilage research, tow and colleagues published work in biioaterials in 2017 showing that exosomes derived from MSC’s could promote cartilage regeneration in osteoarthritis models. And the exoomes carried specific microRNAs that told condondroytes cartilage cells to proliferate and make more extracellular matrix, the structural framework of healthy cartilage. Dr. Deb Muth 15:30for autoimmune conditions. Research by Blazic and colleagues in Frontiers in Immunology in 2014 demonstrated that MSC derived exoomes could shift immune cell behavior from pro pro-inflammatory to regulatory. They could take an overactive self-attacking immune system and restore balance and promote tolerance. And perhaps most exciting brain research, a study by Zinn and colleagues published in the journal of extracellular vesicles in 2013 showed that MSC derived exoomes could cross the bloodb brain barrier. Dr. Deb Muth 16:07That protective shield around your brain that normally keep things out and promote neurological recovery in stroke models. They reduced brain inflammation, promoted neuroplasticity, supported the formation of neural connections, and for mitochondrial dysfunction, which underlies so many chronic conditions, Morrison and colleagues published research and scientific reports in 2017 showing that MSC derived exoomes can actually deliver functional mitochondria or mitochondrial components to damaged cells. They’re not Dr. Deb Muth 16:40just sending instructions, they’re sending spare parts. They’re restoring the cellular powerhouses to produce energy. So why are exoomes fundamentally different from stem cells? Well, exoomes contain no living cells. They can’t replicate. They can’t end graph. And they have virtually no risk of immune rejection or tumor formation. Dr. Deb Muth 17:03Concerns that exist elevate rarely with cellular therapies. They’re essentially biological software updates for your cells. As Fineian Pitiger wrote in their seinal review in stem cells in 2017, MSC derived exoomes represent the active ingredient of stem cell therapy delivered in a cellfree format. That’s the key insight in the in the therapeutic benefit of stem cells and it comes from what they excrete. Dr. Deb Muth 17:33Then exoomes are the secretion isolated, concentrated, and standardized. From a practical clinical standpoint, exoomes offer several compelling advantages. First, consistency. Because exoomes can be isolated, characterized, and standardized, each dose can be remarkably consistent. With living stem cells, there’s variability based on donor age, health status, processing methods, and one batch may be robust, but another might be weaker. Dr. Deb Muth 18:05With exoomes, you can measure the content, measure the potency, and ensure the quality control. Second is storage. Exoomes can be liophalized. They can be freeze-dried and stored at room temperature or refrigerated for extended periods. Stem cells require cryopreserv preservation, careful freezing, careful thawing. They’re fragile. Dr. Deb Muth 18:31Exoomes are remarkably stable. And third, their safety profile. Without living cells, the risk of adverse imunological reactions is dramatically lower. You’re not introducing foreign cells that your immune system might recognize and attack. You’re introducing molecular messages. Fourth is scalability. You can harvest millions, even billions of exoomes from stem cell cultures without ever injecting the cells themselves. Dr. Deb Muth 19:01And you can produce large quantities, standardize them, and make them available to patients. Now, there is a caution here in doing this. The scalability can produce rogue cells, and we want to be cautious of that. So, here’s what I need you to understand. Exoomes don’t force healing. They remind the body how healing works. Dr. Deb Muth 19:24They’re not replacing damaged cells. They’re re-educating the cells you already have. They’re turning back time on the biological programs that got turned off by inflammation, toxicity, trauma, time, and chronic disease. Your body knows how to heal. It’s done its entire life. Every cut that closed, every bone that mended, every infection you fought off, your body orchestrated that healing. Dr. Deb Muth 19:51The problem is that chronic disease, chronic inflammation, toxic exposures, poor nutrition, stress, all of these things disrupt the communication networks that coordinate healing. And exoomes restore that communication. They’re like rebooting a computer that’s frozen. They reset the system and remind it how it’s supposed to function. All right. Dr. Deb Muth 20:14So, this would not be complete if we didn’t talk about regulation because this is where a lot of confusion exists. And I want you to be given a real picture. Not fear-mongering, not pretending. There aren’t regulatory considerations, but the actual practical reality of how regenerative medicine is practiced in the United States today. Dr. Deb Muth 20:38Here’s what you need to understand. The FDA regulates these therapies and they have specific frameworks, but there’s important nuances between regulatory text enforcement priorities and actual clinical practice. And there are also state level regulations that provide additional pathways. The FDA regulates human cells, tissues, and cellular and tissue based products. Dr. Deb Muth 21:05We call them HCT/PPS under two main pathways. Section 361 products are those that meet specific criteria. They’re minimally manipulated, intended for homologous use, meaning these tissues perform the same basic function in the recipient as it did in the donor. They’re not combined with non-tissue components and they’re either autotogus, meaning they come from your own tissue, or they have had minimal systemic effect. Dr. Deb Muth 21:38An example of a clear 361 procedure, your doctor harvests your own bone marrow, we call this PRP, performs minimally processing to or uh perform Yeah. performs minimal processing to concentrate the stem cells through a centriuge and injects it into your arthritic knee the same day. That’s autogus same day but minimally manipulated. Dr. Deb Muth 22:04This is unquestionably legal and is being done in regenerative medicine clinics across the country every single day. So there’s section 351 where products are those that don’t meet all the section 361 criteria. They’re classified as drugs or biologic products and they require FDA approval through clinical trials. Dr. Deb Muth 22:27Now here’s where this gets more nuanced. There are regenerative medicine clinics across the United States using stem cell and exoome therapies in different contexts. First FDA registered clinical trials. These are formal research studies with investigational new drug applications. Patients enroll in trials. They sign informed consents. Dr. Deb Muth 22:48They receive therapies as part of their structured research protocols. And this is completely legal and represents the gold standard for gathering evidence. Second is observational studies and registry programs. Many clinics are collecting systemic data on patient outcomes using these therapies even outside the FDA trials. Dr. Deb Muth 23:12They’re documenting results, tracking safety, and contributing to the growing body of clinical evidence. Third, there’s clinical practice under physician discretion. There are physicians using these therapies based on their own clinical judgment informed consent from patients and their interpretation of the regulatory framework particularly around minimal manipulation and homologous use. Dr. Deb Muth 23:34Now there are also state regulations that provide additional legal frameworks. So, for example, Florida has enacted the Right to Try Act and specific regenerative medicine legislation that allows physicians to offer certain stem cell therapies under the state oversight. Utah has passed similar legislation creating pathways for regenerative medicine products. Dr. Deb Muth 23:57And these state laws recognize that patients should have access to potentially beneficial therapies, particularly when used by trained physicians with appropriate informed consent. The regulatory question often centers around are these products minimally manipulated. Some products clearly are not. They’ve been cultured. Dr. Deb Muth 24:20They’ve been expanded in laboratories and those require FDA approval that they don’t have. The FDA has appropriately shut down clinics using those products. But there are other products that undergo processing that many physicians and manufacturers argue constitutes minimal manipulation. And these tissues are cleared, potentially fragmented or particulated to make them more suitable for injection, preserved using methods like cryopreservation or liophalization and packaged. Dr. Deb Muth 24:54But the cells are not cultured or expanded in the laboratory. The FDA has issued guidance suggesting that many of these processing steps constitute more than manipul minimal manipulation. But many physicians, particularly those who specialized in regenerative medicine for years, disagree with that interpretation and they believe that the processing qualifies as minimal manipulation and that the product should fall under section 361 when used for homologous purposes. Dr. Deb Muth 25:24Is there regulatory debate? Absolutely. The FDA and some clinicians have different interpretations of what constitutes minimal manipulation. But here’s the practical reality. There are hundreds of well-trained, bore certified physicians across the United States offering these therapies every single day. Dr. Deb Muth 25:42They’re doing so based on their understanding of the regulations, their clinical experience, their commitment to patient safety, and their belief that these therapies can help people who have exhausted conventional options. The FDA’s enforcement priorities have focused primarily on the most problematic cases. Clin clinics making blatant disease cure claims, products with documented safety issues, clear cases of cellular expansion and culture, or clinics operating with no medical oversight. Dr. Deb Muth 26:15Reputable regenerative medicine physicians are using products from companies that provide comprehensive documentation of their processing methods. third-party sterility testing, certificates of analysis showing bioactive content, and quality control measures that meet or exceed industry standards. Now, let me be very clear about something. Dr. Deb Muth 26:36Quality matters enormously. Not all stem cells and exoome products are created equal. Research by Burger and colleagues published in the Orthopedic Journal of Sports Medicine in 2021 analyzed 12 commercially available stem cell products and found that many contained zero viable cells, high levels of bacteria, endotoxins and inconsistent growth factor concentrations. Dr. Deb Muth 27:01This is why the company providing these biologic matters tremendously. You want products from manufacturers who provide transport documentation in sourcing and processing. Conduct third-party testing and sterility and potency. Offer certificates of analysis for each batch. Use standardized validated processing protocols. Dr. Deb Muth 27:24Have quality control measures that ensure consistency and don’t make outrageous cure claims or promise. The best regenerative medicine physician carefully vet their suppliers. They don’t use products from companies making unrealistic promises. They use products from manufacturers who are transparent, scientifically rigorous, and committed to quality. Dr. Deb Muth 27:46Now, you specifically ask about homologous use and collagen defects. So, let me address this directly for you. Under the FDA guidance, homologous use means the tissue performs the same basic function in the recipient as in the donor. So for connective tissue, tendons, ligaments, cartilage, fascia, all of that which are collagenrich structures using MSC’s or their derivatives could be considered homologous use. Dr. Deb Muth 28:17MSC’s in their native environment provide structural support to produce extracellular matrix including collagen. Using them to support healing in damaged collagen rich tissues like arthritic joints, torn tendons or degenerative ligaments is arguably the same basic function. So using exoomes derived from MSC’s to support collagen synthesis reduce inflammation and promote tissue healing in the same structures. Dr. Deb Muth 28:46Many practitioners argue this also qualifies as homologous use because you’re supporting the structure and function that MSC’s would naturally support. So here’s the bottom line on the regulatory reality. Regenerative medicine is available in the United States. It’s being offered by highly trained physicians in integrative and regenerative medicine clinics across the country. Dr. Deb Muth 29:11Some therapies are offered in FDA registered clinics and some are offered in observational studies. Some are offered in clinical practice under physician discretion, informed consent, and careful attention to safety. The regulatory landscape is evolving. There are ongoing discussions both federally and state levels about creating clearer pathways for these therapies. Dr. Deb Muth 29:32So, if you choose to go down this road, you want to work with physicians who understand the regulations, who use quality products from reputable manufacturers with rigorous testing and documentation, who are transparent about what they’re using and why, who discuss the current regulatory landscape honestly with you, and who prioritize your safety and truly informed consent above all else. Dr. Deb Muth 29:55This is not a lawless wild wild west. But it is also not as simple as everything is legal and unavailable. It’s a nuanced landscape that requires ethical knowledge. And these practitioners that have this knowledge have got to provide informed patients who understand both the potential benefits and the current regulatory context. Dr. Deb Muth 30:17So let’s have some fun here. Let’s talk about what really matters to you that are listening and that’s what conditions are being supported with these therapies. What does the research show and what are clinicians seeing in actual practice with patients? Because here’s what’s really important. We have both published research evidence and extensive clinical experience. Dr. Deb Muth 30:38And when the two align, that’s when we can feel confident and comfortable about using these approaches. So, let’s start where we have the most substantial evidence. joint health and muscularkeeletal conditions. For arthritis, we have good data. A systemic review by Tan and colleagues published in arthritis research and therapy in 2021 analyzed 20 randomized controlled trials in MSC therapy for knee osteoarthritis. Dr. Deb Muth 31:05They found significant improvements in pain and function particularly in mild to moderate disease. What’s really interesting is when researchers start analyzing whether it was the cells themselves or their secreted factors doing the work. They found that exoomeenriched preparations showed similar benefits to whole cell therapy. Dr. Deb Muth 31:26Now towen colleagues in the biioaterials paper from 2017 demonstrated that MSC derived exoomes could promote cartilage matrix synthesize and reduce inflammation markers. The exoomes carried microarnas that told cartilage cells to make more collagen and proteoglycans, the building blocks of healthy cartilage. Dr. Deb Muth 31:49In clinical practice, physicians are seeing patients with knee, hip, shoulder, and spinal arthritis, experiencing reduced pain, improved function, better motility, and in some cases, measurable improvements in their tissue. I want to share a story here with you because back in 2006, my husband was injured at work. Some of you might have heard me tell this story before. Dr. Deb Muth 32:11Um, he broke two discs in his back and underwent surgery very early on when we started using stem cells. They had put cages and plates in and they used MSC’s to put inside the cage to create a hardened bone so that he could have a fusion and hopefully not have any pain. At the time, what the physician didn’t realize or mistakenly did was he did not put any human bone mixed with these dead cadaavver bone MSC’s. Dr. Deb Muth 32:42And so the MSC’s never grew. They didn’t have anything to grow by. So the plates and the screws just kind of went back and forth for six months before he could see another physician that would look at him differently and understand what actually happened. That was very early on. Today we know so much more than we did before. Dr. Deb Muth 33:01Fast forward to 2014 when my husband was having problems and he couldn’t feel his legs, he couldn’t feel his feet. We decided to undergo uh exoo and stem cell therapy again and we saw a physician in Florida who harvested cells from his bone marrow and his blood and his fat and mixed that all together and then put that back into the back. Dr. Deb Muth 33:27and he had tremendous benefit from it. So, I tell this story because I want you to see the trajectory of how long this has been going on that we’ve been using this and we’re learning as we’re going and things are changing rapidly in this in this world. And so, what we know today and what I’m teaching you today may very well change in a month or six months or a year from now, but we have the foundation at least to understand what is helpful, what is not right now. Dr. Deb Muth 33:54But just be aware that if you’re embarking on exoome or stem cell therapy or MSC’s that you understand that this terrain is going to change. So back to my conversation about what other things can we treat? Well, we can treat tendon and ligament injuries, chronic tennis elbow, Achilles tendonopathy, rotator cuff tears, chronic planter fasciitis. Dr. Deb Muth 34:17These were researched by PA and colleagues in the American Journal of Sports Medicine in 2017 and it showed that bone marrow concentrate injections resulted in improved pain and function compared to steroid injections. Now this mechanism appears to be enhanced collagen remodeling and reduced chronic inflammation. Dr. Deb Muth 34:39These are structural collagenrich tissues using MSC’s or their derivatives for structural support which makes biological sense. It’s homologous use. It’s similar. So clinically we’re seeing athletes, active adults and people with chronic pain who failed physically um failed physical therapy, failed conservative treatments finding relief in this functional uh improvement in this functional world that we live in today. Dr. Deb Muth 35:07So, I want to be clear about what we’re doing here for joint and muscularkeeletal issues. We’re not growing completely new cartilage from scratch or severely destroyed joints. We’re not magically regenerating tissues that’s been gone for decades. That’s not possible here. What you’re doing when you’re using MSSE’s and exoomes is supporting the body’s natural ability to repair, reducing inflam inflammation and damage, and we’re driving progressive degeneration uh or we’re stopping the progressive degeneration. By reducing the Dr. Deb Muth 35:41inflammatory damage, we’re stimulating resonant stem cells that have been dormant. We’re improving blood flow and uh uh oxygen to the tissues like cartilage and tendons. and we’re organizing the body to start creating its own quality collagen as it heals. So, it’s a regenerative support, not a tissue replacement. Dr. Deb Muth 36:07But for many people, this support is lifechanging. So, let’s talk about autoimmune disorders now because this is one of the most exciting and unrecognized applications. autoimmune conditions like rheumatoid arthritis, lupus, MS, Crohn’s disease, ulcerative colitis, Hashimoto’s, they all involve the immune system and the immune system is deregulated. Dr. Deb Muth 36:30And so basically your immune system is seeing this tissue as foreign and it’s attacking it. These MSC’s and their exoomes have profound immune modulatory properties. They don’t suppress the immune system like steroids or imunosuppressive drugs. They modulate it helping to restore balance. So for rheumatoid arthritis, research by Weang and colleagues in stem cells translational medicine in 2016 showed that MSC derived exoomes could shift the balance of immune cells, reducing pro-inflammatory TH7 cells that drive joint disruption uh and increase Dr. Deb Muth 37:08regulatory TE-C cells that maintain immune tolerance. So for MS, a clinical trial by Kasus and colleagues published in archives of neurology back in 2010 evaluated autotogus MSC therapy and MS patients and they found evidence of reduced disease activity, improved neurological function and decreased inflammatory uh lesions on MRI scans. Dr. Deb Muth 37:34The proposed mechanism is MSC’s and their exoomes reduce inflammatory cytoine production promote regulatory imu immune populations support remination of damaged nerves that is rebuilding the protective coating around the nerve fibers and it reduces bloodb brain barrier permeability which prevents immune cells from attacking their brain and spinal cord. Dr. Deb Muth 38:02And so for inflammatory bowel disease, the research by Barnholm uh sorry Barnhorn and colleagues in gut in 2020 showed that MS cell MSC derived extracellular vesicles could support mucosal healing and reduce inflammation in the gut lining. They appeared to restore intestinal barrier function, healing that leaky gut and modulating local immune responses. Dr. Deb Muth 38:30So in clinical practice, physicians are seeing patients with autoimmune conditions, experiencing reduced disease flares, decreasing the need for imunosuppressive medications, improving energy and quality of life, and in some cases extending periods of remission. But here’s what I want you to understand. Dr. Deb Muth 38:52When you see these therapies for autoimmune conditions, we are supporting immune regulation and reducing inflammatory damage. We are not treating or curing the disease in a conventional sense. These therapies work best as part of a comprehensive functional medicine approach that also addresses gut health because 70% of your immune system lives in your gut and environmental triggers like mold, heavy metals, chemical toxins that can drive autoimmune responses, chronic infections that can trigger immune disregulation, stress and nervous system imbalance. And Dr. Deb Muth 39:29these nutritional deficiencies are necessary to help improve the immune function. So regenerative therapy without addressing root causes is like bailing water out of your boat without plugging the hole. You might get temporary relief, but the underlying problem still remains. So let’s talk about neurological conditions. Dr. Deb Muth 39:52And this is where the science gets truly fascinating. for traumatic brain injury and concussion. Research by Zang and colleagues in the Journal of Neurot Trauma in 2015 showed that MSC derived exoomes could reduce brain inflammation, promote neuroplasticity, that’s the brain’s ability to rewire itself and improve cognitive outcomes in animal models. Dr. Deb Muth 40:17The exoomes crossed the bloodb brain barrier, delivered neuroprotective proteins and microRNAs. They reduced inflammation, supported mitochondrial function in injured neurons and promoted both new blood vessels from new blood formation and neurogenesis and the birth of new neurons occurred. Neurological recovery requires a multi-systematic approach. Dr. Deb Muth 40:42Exoomes may support neural repair, but they work best combined with hormone optimization, growth hormone, testosterone, thyroid, pregnnolone, mitochondrial support compounds like NAD, CoQ10, PQQ, carnitine, all of those things that we use traditionally in functional medicine. Now for stroke recovery, there was research by Zinn and colleagues in the journal of extracellular vesicles that showed MSC derived exoomes reduced the size of brain damage and improved neurological recovery in animal models. There was a Dr. Deb Muth 41:19Parkinson’s disease study done by Kimoji and colleagues in the movement disorders in 2018 that suggested that MSSE derived exoomes could support dopamineergic neuron survival and those are the cells that die in Parkinson’s and it can help to reduce neuroinflammation. Clinically, physicians are seeing improvements in patients with postconussion syndrome, chronic traumatic brain injury, early stage cognitive decline, and other neurodeenerative conditions. Dr. Deb Muth 41:52These are not cures, but meaningful improvements in cognitive function, mood, energy, and quality of life. Now, let’s talk about autism spectrum disorder very carefully here because this is a very sensitive but very important topic for families. There have been several clinical trials that have explored MSC therapy for autism. Dr. Deb Muth 42:16Liv and colleagues published research in stem cell translational medicine in 2013 showing improvements in social interaction, communication, and behavioral symptoms in children with ASD who received cord blood MSC’s. Dawson and colleagues in 2017 conducted randomized trial autotogus cord blood infusion and found modest improvements in social communication particularly in children with higher baseline immune dysregulation. Dr. Deb Muth 42:47The proposed mechanisms for modulation of neuroinflammation support the mitochondrial function because many children with autism show evidence of mitochondrial dysfunction, reduction of oxidative stress, improvement in gut brain access dysfunction and modulation of immune dysregulation. In clinical practice, some physicians are seeing improvements in some children, better eye contact, increased language development, reduced sensory sensitivities, improved social engagement, but responses vary significantly, and we cannot predict which children will benefit most. So for Dr. Deb Muth 43:26families considering regenerative approaches for autism, these therapies are supporting the body’s healing mechanisms, reducing neuroinflammation, supporting cellular energy production, modulating immune function. These should only be considered as part of a comprehensive biomedical approach that includes dietary interventions to address food sensitivities, support gut health, environmental toxin removal, particularly heavy metals and chemical exposures, gut healing protocols with targeted probiotics and nutrients, Dr. Deb Muth 44:00metabolic testing and targeted supplementation, and evidence-based on behavioral and developmental therapies. These therapies should only be pursued with practitioners who are honest about what we know and what we don’t know and who follow rigorous safety protocols who never promise cures and who view regenerative medicine as a tool in the comprehensive healing strategy, not a standalone miracle. Dr. Deb Muth 44:26Not only that, these therapies will most likely need to be given several times over the course of this person’s lifetime, possibly even on an annual basis. And this is really important because it is not a oneandone. It is not a one-sizefits-all, and it needs to be looked at as a long-term option for working with autism. So, since we’re looking at stem cells versus exoomes, living cells, with stem cell therapy, you’re receiving living cells that can survive in your body for days to weeks. Dr. Deb Muth 45:02With exoome therapy, there are no living cells, just biological messages they would have sent. So, replication stem cells can potentially replicate. Although therapeutically this happens minimally, exoomes cannot replicate. They deliver the cargo and then they are cleared by your body. With stem cells, it’s primarily paracrine signaling. Dr. Deb Muth 45:28They’re coaching your cells to heal. With exoomes, it’s pure signaling, pure reprogramming your cells without any cellular component. Stem cells as we talked about can be autotogus from your own bone fat, blood or um bone marrow or allergenic from umbilical cord tissue or Wharton’s jelly. Dr. Deb Muth 45:50Exoomes are typically derived from cultured MSC’s often from umbilical cord or bone marrow sources and both can be given by local injection for targeted treatment of joints and tissues and exoomes can be given intravenously for whole body systemic support. both have um low immun immunogicity. I can’t say that word today. Dr. Deb Muth 46:17But exoomes have even lower risk since they contain no cellular material. Now, it’s absolutely critical for you to understand that there are massive quality differences. We’ve talked about this earlier. I want you to be very aware of this and have a conversation with any of the practitioners that you’re considering undergoing this treatment with. Dr. Deb Muth 46:37Here is where it matters more than anything when you’re considering regenerative medicine, the quality of the products and the expertise of the practitioner. Because the reality is not all regenerative medicine products are created equal. We all know that when we take different supplements and not all practitioners understand these therapies at the same depth. Dr. Deb Muth 46:58You want to look for practitioners that are board certified or have some kind of specialized regenerative medicine training. You want to know their clinical experience. How much have they done these procedures? How long have they done this? You want honest communication about the evidence and the limitations in this. Dr. Deb Muth 47:17You want a comprehensive functional medicine approach to go along with these therapies. And you want somebody that’s transparent about their informed consent and their regulatory status. If you have people that are uh claiming that they can cure disease or giving you guarantees, that is not that is not a good practitioner to work with. Dr. Deb Muth 47:37If you have high pressure sales tactics, you need to decide today limited supply for a week. These are marketing manipulations. It’s not medical care. You want to be cautious of extremely low prices because quality regenerative products are expensive to source, process, and test. and store. And if somebody’s offering stem cells or exoomes for a few hundred dollars, seriously, you need to question the quality, the safety, and where they got this from. Dr. Deb Muth 48:09So before undergoing any regenerative therapy, make sure you’re having a very, very lengthy conversation with the person and so you truly understand exactly what you’re getting, how it’s going to be delivered, and what they’re going to do. If there’s one thing I want you to take away from today is that your body has remarkable capacity to heal when given the right biological signals and the right environment. Dr. Deb Muth 48:35Stem cells and exoomes are powerful tools for providing biological signaling that can reduce inflammation, modulate immune function, support tissue repair, and restore cellular communication that’s been disrupted by chronic disease and inflammation. These therapies are available in the United States through trained physicians working in FDA registered trials, observational studies, and clinical practice, and using quality products from manufacturers with rigorous testing and quality control. Dr. Deb Muth 49:04So before you invest in regenerative medicine, do your homework. Ask detailed questions about product quality and source. Verify the products come from reputable manufacturers with certificates of analysis, third-party testing. Work with experienced practitioners. And remember, no injection, no infusion, no biologic can overcome ongoing toxic exposure, chronic stress, poor nutrition, gut dysfunction, and inadequate sleep. Dr. Deb Muth 49:34True healing requires your body and you to actively participate in this healing. If you are unwilling to address the root causes and change the lifestyle factors that disrupted your health in the first place, the biologics can amplify your healing signals, but you have to create the internal environment where healing can actually happen. Dr. Deb Muth 49:56So, I hope this episode has helped you understand regenerative medicine more clearly. Share it with somebody who’s looking for healing beyond the conventional approaches. And until next time, this has been Let’s Talk Wellness Now. Have a blessed day. >> Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Dr. Deb Muth 50:16Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided forformational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. Dr. Deb Muth 50:41While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Your use of information from this broadcast is entirely at your own risk. Dr. Deb Muth 51:00By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time, and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 265 – The Future of Healing: How Exosomes Re-Educate Your Body to Heal Itself first appeared on Let's Talk Wellness Now.

If you've noticed changes in your voice or speech with Parkinson's disease, you might be wondering: "Can this actually get better?" The answer is YES — and in this episode, we show you exactly how. In Part 2 of our Parkinson's Communication Series, we break down the most effective, Parkinson's-specific speech therapy approaches, including: • LSVT LOUD (Look up local clinicians HERE: https://www.lsvtglobal.com/lsvtfindclinicians)  • SPEAK OUT! (Look up local clinicians HERE: https://parkinsonvoiceproject.org/program/find-a-provider/) • How these programs are similar—and how they're different • What the core voice exercises actually look like • Simple demonstrations of the most important "bread-and-butter" techniques We also walk through how to access speech therapy, what to expect from treatment, and how ongoing programs like Get LOUD! Stay LOUD! ***SEE BELOW*** help people maintain progress over time with guided practice and support. If you're living with Parkinson's—or supporting someone who is—this episode will give you a clear, practical understanding of what actually works when it comes to improving speech and communication.

People living with Parkinson's disease (PD) and their loved ones develop countless ways to adapt and make daily life easier as symptoms change. Members of The Michael J. Fox Foundation's Patient Council and their care partners share decades of collective wisdom on living with PD. They came together for a live conversation at MJFF's New York City offices to discuss what they've learned along their own disease journeys, from practical strategies and tools that make daily life easier to the mindsets and mantras that guide and sustain them. In this episode of the MJFF Parkinson's Podcast, patient council member and guest host Larry Gifford, diagnosed with PD in 2017 and president of PD Avengers, together with his wife and care partner Rebecca, reflect on the advice given.Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0The Foundation's landmark study, the Parkinson's Precision Medicine Initiative, also known as PPMI, is recruiting volunteers. Join the study that's changing everything at michaeljfox.org/podcast-ppmi.Mentioned in this episode:Researchers are studying the link between sense of smell and brain health. People with and without Parkinson's can help by taking a scratch-and-sniff test. It's free, mailed to your home and takes just 15 minutes to complete. mysmelltest.org/getstarted

Your microbiome could be the missing link behind Parkinson's disease, chronic inflammation, sugar cravings, constipation, and more.     In this fascinating episode of the Lisa Fischer Said Podcast, Lisa sits down with microbiome researcher and entrepreneur Martha Carlin to unpack the surprising connection between gut health, brain health, and chronic disease. After her husband was diagnosed with Parkinson's at just 44 years old, Martha began a decades-long journey into the science of the gut microbiome, probiotics, stool testing, and the toxic burden affecting modern health.     They discuss the gut-brain axis, dopamine, constipation as an early warning sign of disease, probiotics, fecal transplants, red light therapy, sunlight exposure, and why your daily bowel habits may predict your long-term health. Martha also shares how dietary changes dramatically improved her husband's symptoms and how her research led to groundbreaking discoveries in microbiome science.    

Have you ever noticed how we almost work twice as hard to get ready to leave for vacation? We pack our schedules with an endless to-do list, run ourselves ragged, and then carry the office right along with us in our pockets.In this rejuvenating episode, Laurie Reynoldson shares her reflections after returning from a completely offline, computer-closed "ass-sitting vacation" on a tropical beach. She explores the immense pressure high-achieving women place on themselves to remain constantly available, and why sacrificing our personal time to make others comfortable is a losing game.This episode is a masterclass in learning how to set boundaries, separate "trips" from true "vacations," and protect your life's most valuable asset: you.In this episode, you'll learn:The Pre-Vacation Trap: A look into Parkinson's Law and why we create massive 45-item to-do lists just to earn a few days away.The Power in the Pause: The mental and creative breakthroughs that only happen when you step entirely away from technology and the daily hustle.The Broken Client Boundary: Laurie shares a cautionary tale from her law firm days about the ridiculous extremes professionals go to hide the fact that they are taking time off.Trips vs. Vacations: Why dynamic European itineraries are wonderful, but why you still need an absolute "do-nothing" reset on the calendar.The Living Legacy: How prioritizing your own rest and dreams sets a critical behavioral example for your daughters and your sons.The Big Takeaway: You cannot run yourself ragged and expect to have sustainable energy for your life's work. If you don't protect the asset, the asset won't be able to do the big things you are dreaming about.LINKS + MENTIONS:The Best Life Planner: Implement the daily "Morning 5-10-5" system Laurie used on the beach to ground her day in gratitude and vision.Essentialism by Greg McKeown: The book behind the philosophy of "protecting the asset".The Best Life Mastermind: Ready to get out of your everyday environment so you can focus on your life? Join the waitlist for the exclusive 9-month cohort starting this September.Support the Show: If you enjoyed this reminder to rest, please follow the show, leave a five-star rating, and review us on Apple Podcasts or Spotify!

In this episode of the Optimal Body Podcast, Doc Jen and Doctor Dom welcome Dr. Kelsey Barr, a physical therapist specializing in chronic pain and fall prevention. Kelsey shares her journey from fitness to PT, inspired by working with elderly patients and those with Parkinson's disease. She discusses how chronic pain affects the nervous system, the importance of strength and balance training and exercise for aging adults, and her comprehensive approach to fall prevention, including balance training, reactive training, and body awareness. Kelsey also introduces her online program, Safe and Stable Solutions, designed to help people live safer, more independent lives through effective balance training. Zulu Weighted Vest: Upgrade your everyday movement with the ZULU Weighted Vest — designed to increase calorie burn, naturally engage your core, and improve posture with every step. Perfect for walks, workouts, and daily errands. Use code OPTIMAL for 20% off at checkout. Needed Discount: Jen trusted Needed Supplements for fertility, pregnancy, and beyond! Support men and women's health with vitamins, Omega-3, and more. Used by 6,000+ pros. Use code OPTIMAL for 20% off at checkout! Kelsey's Resources: SASS Website Dr Kelsey on IG SASS on IG SASS on FB Kelsey's Course We Think You'll Love: Lifting for Longevity Jen's Instagram Dom's Instagram YouTube Channel For full show notes and resources visit https://jen.health/podcast/461 What You'll Learn: 3:11 Kelsey shares her journey from fitness to physical therapy, and how working with elderly and Parkinson's patients sparked her passion. 8:04 Kelsey explains how fear and a heightened nervous system impact chronic pain, and how she uses breathing to calm patients. 11:13 Kelsey discusses... Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Author Rachel Reid (Heated Rivalry) joins Nicole to chat about the wild, viral success of her steamy queer romance novels and the hit TV adaptation. She shares how she met her husband while performing a smelly, hockey-themed burlesque act, and the dynamic that keeps their 20-year one sided open marriage working for them. She discusses the creative process behind writing explicit romance between men, and exactly why she absolutely does not want to hear your glowing reviews of her work. Plus, Rachel opens up about navigating her recent Parkinson's diagnosis.Watch this episode on our YouTube channel at https://www.youtube.com/@WhyWontYouDateMePodcastTake our listener survey and shape the future of the podcast!Support this podcast by checking out our sponsors:• FirstLeaf: Get personalized wines, delivered. Head to TryFirstleaf.com/DATEME to sign up and you'll get 50% off your first box PLUS free shipping for an entire year• Wayfair: Get prepped for patio season for way less. Head to Wayfair.com right now to shop all things home. Wayfair. Every style. Every home.Follow:All Links: linktr.ee/whywontyoudatemeTour Dates: linktr.ee/nicolebyerwastakenYouTube: @WhyWontYouDateMePodcastTikTok: @whywontyoudatemepod Instagram: @nicolebyerX: @nicolebyerThis is a Headgum podcast. Advertise on Why Won't You Date Me? via Gumball.fm.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Donald Trump has left China after talks with Xi Jinping that the US president says have settled "a lot of different problems". President Xi called it a "landmark" visit, but gave no details of any new agreements. On Iran, President Trump said the Chinese president would pressure Tehran to re-open the Strait of Hormuz. Mr Trump also said he didn't think there was a risk of conflict between China and the US over Taiwan. Also: American media reports say the US is preparing to indict the former Cuban president, 94-year-old Raul Castro. There's been a large prisoner swap between Ukraine and Russia as the two sides ramp up their aerial attacks. The BBC has traced dozens of social media accounts - which post AI-generated anti-immigration content about the UK - to countries such as Sri Lanka and Vietnam. And the singer-songwriter with Parkinson's disease using AI to help him make music again. The Global News Podcast brings you the breaking news you need to hear, as it happens. Listen for the latest headlines and current affairs from around the world. Politics, economics, climate, business, technology, health – we cover it all with expert analysis and insight. Get the news that matters, delivered twice a day on weekdays and daily at weekends, plus special bonus episodes reacting to urgent breaking stories. Follow or subscribe now and never miss a moment. Get in touch: globalpodcast@bbc.co.uk

Author, journalist, and co-founder of DoubleBlind, Madison Margolin, joins Raghu to explore her latest project: creating a roadmap to tripping, microdosing, and beyond.Grab your copy of The DoubleBlind Guide to PsychedelicsIn this episode, Madison and Raghu step into the world of: Emerging theories of Ibogaine use in Parkinson's treatment Defining ‘psychedelics' and Dr. Ben Malcom's (aka The Spirit Pharmacist) view on psychedelic & somatic awarenessWhat the clinical world can take away from indigenous plant medicine ritualsRam Dass's journey from psychedelic research to spirituality Spiritual seekers: from India to South America How regular practice helps us connect to deeper layers of realityFeeling beyond time and space Punctuating psychedelic experiences with spiritual practiceAltered states in the history of Judaism Psychedelics for war zones, trauma, and religious leadersAccessing your set, setting, and mental health dispositions “Doing psychedelics under the stewardship of an indigenous culture is equally legitimate to doing it in a clinical context, and it's also legitimate to do it at a Grateful Dead show. What I really want to get at is that the way the tribes or indigenous cultures regard these medicines is through community, song, prayer, connection to nature, reciprocity, those are all values that even the clinical world can borrow and emulate as they design their trials." –Madison MargolinAbout Madison Margolin:Madison is an author and journalist who straddles California, New York, and the Israel-Palestine region, with a focus on psychedelics, cannabis, and Judaism — jokingly referring to it as “Jews & Drugs.” Her reporting also spans culture, policy, and science. At the center of her work is a sustained curiosity about how people transcend the mind to access something larger than themselves, whether through psychedelics, spirituality, meditation, art, or somatic practice. Much of her writing explores the different ways people nourish the soul. Madison is the co-founder of DoubleBlind, the print and digital magazine that covers psychedelics and their intersections with mental health, spirituality, environmental justice, and social equity. She also co-founded the Jewish Psychedelic Summit and hosts the podcast Set & Setting on the Be Here Now Network. She has worked in journalism since 2014, with bylines in outlets including Rolling Stone, Vice Media, Playboy, High Times, Tablet Magazine, and Nylon.She began her journalism career with a cannabis column at The Village Voice shortly after graduating from Columbia Journalism School. Before that, she lived in Tel Aviv, where she worked with Israel's African refugee community. Earlier in her life, she lived at the Cloyne co-op while studying rhetoric and linguistics at the University of California, Berkeley.She is a language enthusiast who speaks or dabbles in French, Russian, Yiddish, and Hebrew. Outside of work and writing, she is usually dancing, spinning a hula hoop, or practicing yoga.Madison Margolin is also the author of Exile and Ecstacy, a book on Growing Up with Ram Dass and Coming of Age in the Jewish Psychedelic Underground. Learn more about Madison's work at madisonmargolin.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The person you love is either raising your hormones or destroying them, and most people have no idea which one is happening to them. John Gray, the author of one of the most beloved relationship books of all time, returns to reveal how your relational environment directly shapes your biology, and what you can do right now to hack it. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR John Gray wrote Men Are from Mars, Women Are from Venus, the number one bestselling book of the entire decade and one of USA Today's top 10 most influential books of the last quarter century. His books have been translated into 45 languages across more than 100 countries. But what most people miss is that Gray is also a pioneer in the intersection of hormonal health, brain optimization, and human performance, a biohacker before the word existed. His newest book, Men Are from Mars for Women Only: Be Happy With or Without a Man, is the first in a six-part series packed with cutting-edge insights on relationships, biology, and longevity. Host Dave Asprey and John Gray go deep on the hormonal mechanics of desire, attraction, and emotional regulation, covering why societal testosterone collapse is driving relationship breakdown, how estrogen and testosterone function as a polarity system in both men and women, and why the relational environment you create every day is either building or destroying your biological potential. They also cover lithium orotate as a brain optimization supplement, the anti-aging power of semen retention, pre-digested protein as a nootropics-adjacent tool for brain healing, and how fasting and discipline directly boost testosterone. Gray even shares how he reversed early-stage Parkinson's using biohacking techniques and now maintains a testosterone level of 600 at age 74, with zero pharmaceutical support. This is essential listening for anyone serious about biohacking, longevity, anti-aging, supplements, human performance, brain optimization, functional medicine, metabolism, and hacking the biology of love and attraction. You'll Learn: Why testosterone collapse is the hidden driver behind modern relationship failure How your partner's emotional state directly affects your hormones in real time The prolactin trap that kills sexual desire in long-term relationships and how to escape it Why lithium orotate is one of the most underrated supplements for dopamine and serotonin balance How mirror neurons open and close based on stress, and what that means for emotional connection The five-finger ask technique that raises estrogen and testosterone simultaneously How pre-digesting protein with enzymes achieves 93 percent assimilation and supports brain repair Why fasting, discipline, and semen retention are among the most powerful testosterone-building tools available Thank you to our sponsors! - Active Skin Repair | Get 25% off your order until May 21, after that, it drops back to 20%, visit ActiveSkinRepair.com and use code DAVE. You can also find Active Skin Repair on Amazon and at your local CVS - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Igniton | Try risk free at Igniton.com and use code DAVE at checkout for 15% off. Backed by a 30-day money back guarantee. - Pique | Go to Piquelife.com/dave for 20% offDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: John Gray, Men Are from Mars Women Are from Venus, testosterone, estrogen, hormonal health, hormone optimization, prolactin, oxytocin, dopamine, serotonin, lithium orotate, mirror neurons, longevity, anti-aging, biohacking, supplements, fasting, semen retention, NoFap, multi-orgasmic men, sexual health, libido, foreplay, relationship advice, men and women, emotional regulation, stress hormones, cortisol, adrenaline, epigenetics, Parkinson's disease, protein assimilation, digestive enzymes, pre-digested protein, whey protein, casein protein, Mars Venus app, five finger ask, Venus talk, emotional processing, trauma, post traumatic stress, testosterone collapse, relationship breakdown, attraction, desire, masculine feminine polarity, Dave Asprey, 40 Years of Zen, hormones and behavior, relational biology, conscious relationships, mirror neurons and sex, luteinizing hormone, monk celibacy, meditation Resources: • Grab All Of John's Books And Content At: https://www.marsvenus.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:45 – Intro 02:23 – Testosterone & Relationship Collapse 02:41 – Hormones & Stress 08:37 – Attraction & Sexual Polarity 10:36 – Communication & Conflict 20:21 – Emotions & Trauma 21:27 – Mirror Neurons 31:03 – Masculine vs. Feminine Energy 45:05 – Lithium Orotate 49:52 – Protein & Longevity 54:02 – Semen Retention 59:46 – Prolactin & Long-Term Desire 1:09:12 – Sex & Mirror Neurons 1:12:45 – The Five Finger Ask See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, my guest is Dr. Casey Halpern, MD, a professor of neurosurgery at the Perelman School of Medicine at the University of Pennsylvania. We discuss how deep brain stimulation and other neuromodulation approaches are being used to treat Parkinson's disease, obsessive-compulsive disorder (OCD), binge eating disorder and depression-related symptoms. We also explore the brain circuits that drive compulsions, cravings and impulsivity, as well as emerging non-invasive tools for predicting and treating harmful behaviors. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Rorra: https://rorra.com.huberman Timestamps (00:00:00) Casey Halpern (00:00:20) Neurosurgery, Deep Brain Stimulation (00:04:19) Obsessive-Compulsive Disorder (OCD) & Treatments (00:10:11) Sponsor: Function (00:11:49) OCD Brain Areas, Addiction (00:14:12) Nucleus Accumbens, Risk & Rewards; Binge Eating Disorder (00:18:28) Sponsor: AG1 (00:19:46) Non-Invasive Brain Stimulation, Transcranial Magnetic Stimulation (00:27:31) Sponsor: Rorra (00:28:46) Awareness of Cravings, Severe Binge Eating Disorder (00:32:51) Artificial Intelligence/Machine Learning & Predicting Impulsive Behavior (00:36:57) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices