Podcasts about Phase

The Golden State Valkyries: Post-Eurobasket Phase We discuss the state of the Valkyries after their loss to the Minnesota Lynx on July 5, 2025. #wnba #valkyries #basketball

In this episode, Coach Debbie Potts explores the vital role your liver plays in keeping you fit, strong, and energized from the inside out. If you're dealing with fatigue, weight gain, hormonal imbalances, poor recovery, or brain fog, your liver might be overloaded—and it's time to support it with a Root Cause approach. Debbie walks you through the three phases of liver detoxification using a simple, relatable analogy: doing your laundry:

AC's long national nightmare is over! We're joined by Rod Morrow - a mainstay of the show - to discuss the second half of IRONHEART, including, but not limited to, the introduction of a certain devilish character! Follow Rod: @rodimusprime JOIN OUR PATREON: patreon.com/mcuniversitypod Vote on the Phase 5 Awards: https://docs.google.com/forms/d/e/1FAIpQLSdvvJCrFhtgTqPB1cjhy8YXSc7UrOH_1vWdbL6Ew3Rv0M5j9w/viewform Follow the show: @mcuniversitypod Follow AC: @anthonycanton_3 Follow Jake: @thejakechristie

Hi friends! I have a new solo podcast episode going live, and in it, I'm sharing a practice that has become a cornerstone of my quarterly health routine: the EquiLife Detox. This episode dives into why supporting your body's natural detoxification pathways is more critical than ever in our modern environment. Here's a sneak peek at what we're diving into in this episode: What a detox truly entails (moving beyond restrictive juice cleanses) and why seasonal detox support can benefit nearly everyone experiencing fatigue, hormonal imbalances, allergies, or unexplained symptoms. The reality of daily toxin exposure from our food, water, air, and common products, and how this overload can manifest as symptoms like brain fog, stubborn weight, and skin issues. The science behind Phase 1 and Phase 2 liver detoxification, explaining why supporting both is essential for effective toxin elimination and to avoid common "detox flu" symptoms. My personal experience with the detox, detailing observed benefits such as increased energy, clearer skin, deeper sleep, and a significant reset of cravings. A discussion on why natural detoxification can be challenging in today's environment due to pervasive toxins and depleted nutrient content in food. My favorite modification tips for the detox, covering strategies for adjusting fasting days, incorporating additional fuel, and navigating coffee consumption. and so.much.more! Partners: Check out We Feed Raw! Maisey goes crazy for this! I use it as a topper for her kibble or mix it into her pup loaf. You can try the raw version, the raw dehydrated kibble, and they'll help you customize a plan for your pup. Use FITNESSISTA40 for 40% off your Meal Plan Starter Box here! The Lifewave X39 patches have been a gamechanger for my energy; the Pilot is obsessed, too! Check them out here.  Check out my new favorite red light device here, and use the code FITNESSISTA for a huge discount. I've been using Nutrisense on and off for a couple of years now. I love being able to see how my blood sugar responds to my diet and habits, and run experiments. You can try out Nutrisense here and use GINA50 for $50 off. If any of my fellow health professional friends are looking for another way to help their clients, I highly recommend IHP. You can also use this information to heal yourself and then go one to heal others, which I think is a beautiful mission. You can absolutely join if you don't currently work in the health or fitness industry; many IHPs don't begin on this path. They're friends who are passionate to learn more about health and wellness, and want to share this information with those they love. You can do this as a passion, or start an entirely new career. You can use my referral link here and the code FITNESSISTA for up to $250 off the Integrative Health Practitioner program. I highly recommend it! You can check out my review IHP Level 1 here and my review of Level 2 here. Thank you so much for listening and for all of your support with the podcast! Please be sure to subscribe, and leave a rating or review if you enjoyed this episode. If you leave a rating, head to this page and you'll get a little “thank you” gift from me to you. 

Welcome back to the third episode of our Metabolism Series – and today, I'm tackling the one topic that gets everyone in their feelings: FAT LOSS. But let's be clear… I'm not talking crash diets, cabbage soup, or “skinny by Saturday” nonsense. I'm talking fat loss done right. If you're a woman over 40 who's been dieting harder than a 2000s fitness competitor and still not seeing results, this episode is your permission slip to break up with the BS and start playing the long game. Inside this episode, I'm breaking down: Why your obsession with the scale is tanking your results What it actually means to change your body composition The 12–16-week fat loss phase (and why you should treat it like a season, not a lifestyle) Why that 1–2 lb per week “rule” is total trash How to wade into fat loss like a rockstar (without mourning your almond butter) Plus, you'll get the real scoop on why slashing calories, skipping meals, and fasting your face off is the exact opposite of what your perimenopausal body needs. Spoiler: There is a better way. And it starts by finally stop bullying your body and start to treat it like the partner it is. Bonus: I've got a Metabolism Quiz linked below that'll tell you exactly what phase you're in right now—fat loss, maintenance, or reverse. No more guessing, no more Googling. And if you're tired of white knuckling your way through another diet plan, grab my upcoming Metabolism Reset Guide to start building a sustainable fat loss roadmap that actually fits your real life. Hit play, grab a notebook (or your favorite protein smoothie), and let's get real about what it takes to get results at this stage of life, without burning out, bingeing, or blowing up your social life. Because my queen, fat loss isn't forever… but freedom from diet drama? That's the goal. Screenshot this ep, tag me on IG or hop into the Fit Girl Magic Facebook group and share your biggest takeaway! Facebook group Free Resources:   Website:    Is Your Metabolism Tired AF   FREE Guilt Free Alcohol Guide    

Die Fahrt des Zeppelin Luftschiffes LZ 7 am 28. Juni 1910 geriet zu einer Beinahe-Katastrophe. Der Begeisterung in Bevölkerung und Presse schadete diese Havarie jedoch nicht. Denn es ging in dieser frühen Phase der Luftfahrtgeschichte um mehr als eine neue Form des Reisens. Es ging um das Renommee der ganzen Nation. Autor: Thomas Grasberger (BR 2025)

Episode 33: Insulation & Drywall – How to Prepare Your Custom Home for Energy Efficiency & Interior FinishesIn this episode of Building With Breven, we officially enter Phase 2 of the home building process! Inspired by our most popular episode (Ep. 22), this is the fifth installment of our 7-part mini series on how to build a custom home, and we're diving deep into insulation and drywall—a key transition point between rough construction and finished interiors.Host Steven Byrnes of Breven Homes breaks down what to expect during the insulation and drywall phase of your custom home construction, and what you need to check before moving forward to paint and trim.In this episode, you'll learn:

You quit drinking to feel better — and you do. But you also feel... a little lost. Your old life doesn't quite fit, and the new one still feels unfamiliar. Welcome to the identity crisis no one warned you about. In this episode, we're talking about what really happens after you get sober — the part beyond the cravings and the willpower. Because when alcohol is no longer part of your life, it takes your old routines, confidence, and identity with it. If you've ever thought, “I don't even recognize myself anymore…” this episode is for you. You'll learn: Why feeling disconnected is actually a normal part of early sobriety The 3 phases of the identity shift that every sober woman goes through How to get out of the “in between” phase and build a life that actually feels aligned Plus, I'll give you practical tools and journal prompts to help you reconnect with who you really are — without alcohol. This isn't just about staying sober — it's about becoming the person you were always meant to be.  

In this episode I break down the three essential phases of healing after an affair: Stop the Bleeding, Rehabilitation, and Healing.These stages are crucial for rebuilding trust and healing the pain of betrayal.The first phase is about managing the initial shock and emotional impact.In phase two, you'll do the deeper work of understanding what led to the affair and healing both individually and together.Phase three is where you begin to envision and create a new future, even if it looks different from what you expected.I'll explain why each phase is essential, how to avoid getting stuck, and why having the right support is key to moving forward.Struggling to decide whether to stay or go in your marriage and you're serious about finding that answer? Book a Truth & Clarity Session with a member of my team. We'll discuss where you are in your marriage and explore if there's a fit for you and I to work together so you can make - and execute - the RIGHT decision for YOU and your marriage.

apply for 1-1 coachingFat loss works best when your body is ready for it - not just when you "feel like" starting a diet. In this episode, we walk through the exact signs your body and mind are truly prepared for a fat loss phase, including metabolism, cycle health, energy, hunger cues, and more. I hope you've loved the priming series!

Almost 50 schools across Ireland have signed up to a new programme by US EdTech company Merlyn Mind and The Learnovate Centre to pilot a ground-breaking AI assistant tool for teachers. The programme is the largest trial of the Merlyn Origin AI assistant outside of North America. Supported by Learnovate, a learning technology research centre in Trinity College Dublin, the programme will see 300 teachers across 48 post-primary and primary schools utilise the Merlyn Origin AI technology in the classroom to provide students with a personalised, dynamic and interactive learning experience. The Merlyn Origin AI assistant tool been designed to support educators by streamlining the administrative and repetitive aspects of teaching. By leveraging generative AI, the system enables teachers to create lesson plans, generate grading rubrics and acquire instant feedback from their students with the push of a button. It also offers unique voice-controlled technology that allows teachers to operate classroom devices - from computers to front-of-class displays - entirely hands-free, freeing them up to focus on engaging directly with students. Phase one of the Irish pilot scheme during the academic year, just ended. Researchers will then incorporate feedback from teachers and learners into the technology ahead of phase two, beginning at the start of the 2025 academic year. It is hoped the success of the pilot will lead to a wider take-up of the technology in Irish classrooms. Merlyn Origin is actively used in more than 10,000 classrooms across the US where studies have found it to be effective at helping teachers reduce time spent on administrative tasks, leaving more time for teaching and learning, in as little as seven weeks. Research has also found that teachers using Merlyn experience reduced technostress - stress caused by technology tools and processes required in their work. Mullingar Community College in Co. Westmeath took part in a limited trial of the cutting-edge AI technology earlier this year. The success of that project has paved the way for the current pilot programme. Merlyn Mind has collected a series of industry honours in recent years, including Best AI Platform at the 2024 Global EdTech Awards and Best AI Solution at the 2024 Ed Tech Cool Tool Awards. The AI tool also won the Trendsetter category at the 2023 EdTech Awards, and the Back to School Primary and Secondary Education Awards at the Tech and Learning Awards of Excellence in 2023. Jason Mayland, Vice President of International Business Development at Merlyn Mind, says: "We're extremely excited to begin piloting our Merlyn Origin AI assistant in 48 schools across Ireland. This is the largest trial of our technology in classrooms outside North America where we've already seen Merlyn Origin produce fantastic results in terms of reducing technostress and time teachers spend on administrative tasks. "We're grateful to The Learnovate Centre, with whom we are a Patron Member, for its support on this project, which is a key milestone on our journey to bring Merlyn Mind to the European market." Learnovate Head of Membership Services Dave Farrelly says: "Learnovate is delighted to partner with Merlyn Mind on this pilot scheme for its AI assistant for teachers. AI has vast potential to revolutionise the classroom experience, which is why Learnovate is committed to supporting cutting-edge research in this area. It's important that we fully embrace this technology so that we maximise the benefits for teachers and learners."

Would you like access to our advanced agency training for FREE? https://www.agencymastery360.com/training Let's get real. If you're stacking your agency's foundation on $20/month AI tools, congrats—you're in the honeymoon phase. But don't confuse cheap for stable. This ain't gonna last. We're in the Uber moment of AI. Remember those $3 rides in 2015? Promo codes flying like candy? Everyone thought, “This is amazing.” Then BOOM—same ride today costs $30, and you don't blink. Why? Because they normalized the spend. AI is doing the same damn thing right now. The Calm Before the Price Surge I was chatting with an agency owner the other week—four-person team doing the work of twenty. She's saving close to $800K in salary using AI. Impressive? Hell yeah. But also? Fragile. Because when AI replaces two full-time employees, it's not going to stay cheaper than lunch forever. These platforms are buying loyalty today so they can raise rates tomorrow. And when they do, the agencies who built real systems will survive while the rest scrambles. Automation Without Documentation = Fragile AF Here's the trap I see all over the place: Agencies getting lean and mean with automation… but not documenting jack. So when a tool changes, prices spike, or a platform shifts—what happens? They're rebuilding from scratch. Again. Smart operators are using AI to build leverage, not just save time. And they're documenting the whole playbook outside the tools. Prompts. Logic. Decisions. Workflows. Everything. Because they know when OpenAI changes the rules (and they will), they'll just pivot—without panic. 3-Phase AI Survival Plan (That Actually Makes You Money) Phase 1: Audit + Adapt List every AI tool you use. Ask: “If this cost 10x tomorrow, what breaks?” Document your workflows without AI. Don't skip this. You're looking for landmines now, so you're not surprised later. Phase 2: Build AI-Augmented IP Productize one service using AI—but don't lean on it 100%. Build templates based on your brain, not just the bot's. Train your agents and save the training outside the tool. Think like a software company, not a freelancer with ChatGPT. Phase 3: Future-Proof Your Value Sharpen your skills. AI is smart, but notstrategic. Build one offer that works with zero automation. Stay close to smart operators. This is a gold rush. Don't go it solo. This Isn't Anti-AI. It's Pro-Sanity. AI is a tool. It's not your team. It's not your strategy. And it's definitely not your moat. Use it. Document it. But don't depend on it. Because when the rules change—and they will—the agencies that built real systems and resilient IP will still be standing. Want a plan to build smarter leverage in your agency? Check out the Agency Playbook. It's the 8-system framework we've used to help agency owners like Derek Champagne scale from 7- to 8-figures in under a year.

If you're anything like me, you've probably looked back and thought, “Why didn't I know this 10 years ago?” That's exactly what today's chat is about - my top five health game-changers I wish I had embraced earlier. Whether you're 25 or 75, these insights can shift the needle in how you feel, look, and thrive. From nutrition tracking without guilt to finally getting that high-quality protein in, these tips aren't about restriction - they're about empowerment. I'm opening up about what's worked, what didn't, and why strength training, ditching the processed stuff, and even allowing yourself to be hungry can be revolutionary. This one is packed with real-life examples, scientific backing, and simple steps to get started without getting overwhelmed. What we're tackling: Track your food with intention, not shame. Ditch skinny, build strong with progressive overload. Prioritize protein without obsessing. Phase out processed foods gradually. Embrace hunger and stop snacking aimlessly. Meditation App : Simply Being App Get Weekly Health Tips:  thrivehealthcoachllc.com Let's Connect:@‌ashleythrivehealthcoach or via email: ashley@thrivehealthcoachingllc.com Podcast Produced by Virtually You! Sources: Tracking Nutrition Burke, L. E., Wang, J., & Sevick, M. A. (2011). Self-monitoring in weight loss: A systematic review of the literature. Journal of the American Dietetic Association, 111(1), 92–102. https://doi.org/10.1016/j.jada.2010.10.008 Raber, M., Patterson, M., & Jia, W. (2021). A systematic review of the use of dietary self-monitoring in behavioral weight-loss interventions: Current practices and future recommendations. Public Health Nutrition, 24(17), 5885–5913. https://doi.org/10.1017/S1368980021002381 Prioritizing High-Quality Protein Holt, S. H. A., Brand Miller, J. C., Petocz, P., & Farmakalidis, E. (1995). A satiety index of common foods. European Journal of Clinical Nutrition, 49(9), 675–690. Ortinau, L. C., Culp, J. M., & Hoertel, H. A. (2014). Effects of high-protein vs. high-fat snacks on appetite control, satiety, and eating initiation in healthy women. Nutrition Journal, 13, 97. https://doi.org/10.1186/1475-2891-13-97 Dhillon, J., Craig, B. A., Leidy, H. J., Amankwaah, A. F., Jacobs, A., Jones, B. L., & Jones, J. B. (2016). The effects of increased protein intake on fullness: A meta-analysis and its limitations. Journal of the Academy of Nutrition and Dietetics, 116(6), 968–983. https://doi.org/10.1016/j.jand.2016.01.003 Zhu, R., et al. (2021). Effect of a high-protein, low-glycemic index diet on hunger and weight maintenance: Results from the PREVIEW study. Frontiers in Nutrition, 8, 649928. https://doi.org/10.3389/fnut.2021.649928 Strength Training vs. Cardio Saeidifard, F., Medina-Inojosa, J. R., West, C. P., & Lopez-Jimenez, F. (2019). The role of resistance training in the prevention and management of chronic disease. European Journal of Preventive Cardiology, 26(5), 505–515. https://doi.org/10.1177/2047487318822333 Momma, H., et al. (2022). Muscle-strengthening activities and risk of all-cause and cause-specific mortality: A systematic review and meta-analysis of cohort studies. British Journal of Sports Medicine, 56(10), 755–763. https://doi.org/10.1136/bjsports-2021-105061 Cutting Ultra-Processed Foods Monteiro, C. A., Cannon, G., Levy, R. B., Moubarac, J. C., Louzada, M. L., Rauber, F., ... & Jaime, P. C. (2019). Ultra-processed foods: What they are and how to identify them. Public Health Nutrition, 22(5), 936–941. https://doi.org/10.1017/S1368980018003762 Srour, B., et al. (2019). Ultra-processed food intake and risk of cardiovascular disease: Prospective cohort study (NutriNet-Santé). BMJ, 365, l1451. https://doi.org/10.1136/bmj.l1451 Mindful Hunger / Fasting Bruce, L. J., & Ricciardelli, L. A. (2016). A systematic review of the psychosocial correlates of intuitive eating among adult women. Appetite, 96, 454–472. https://doi.org/10.1016/j.appet.2015.10.012 Longo, V. D., & Panda, S. (2016). Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metabolism, 23(6), 1048–1059. https://doi.org/10.1016/j.cmet.2016.06.001

Voici un court extrait de l'épisode (complètement fou :^) qui sort ce jeudi. Bonne écoute ! Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode, I speak with Trond Knutsen Hundsnes, Head of Early Phase and Subsurface Capital Decommissioning Projects at Equinor. For those of you navigating leadership, project portfolios, or trying to understand how to build a meaningful engineering career—this episode offers practical examples of how to do just that.What struck me most was how Trond balances risk, trust, and team empowerment across some of the most complex projects in the Norwegian Continental Shelf. Whether you're a graduate engineer, mid-career, or in a leadership role, you'll likely relate to the questions he raises about timing, motivation, and how to manage constant change in the energy sector.We talk about:How to lead change across a mature asset base while keeping people motivatedWhy early-career engineers shouldn't rush progressHow broad technical exposure helps you ask better questions as a leader

Join Michael and mom Ashlee as they talk to Michael Canney, Ph.D., who is leading an exciting Phase 3 clinical trial that holds the promise of reshaping brain cancer treatment in particular in glioblastoma. This trial is testing a new surgical implant using ultrasound to enhance chemotherapy effectiveness against brain tumors, in particular because of the blood/brain barrier. Mike is at the forefront of efforts at 40 clinical sites worldwide, 20 in the US, working to push the boundaries in brain cancer treatments. The conversation takes a personal turn, as always with Michael and mom :)find out more about this phase 3 clinical trial for Glioblastoma:https://sonobird.eu/More info about Carthera:https://carthera.eu/More about Michael Canney on Linked In:https://www.linkedin.com/in/michael-canney-ph-d-42457b5/

I recently turned 28 and have decided that I want to devote the next 2 years to glowing up so that I can start my 30s off as the best version of me. Now with that being said, the timeline is not what's important here, regardless of your age I hope todays episode can help you develop your long term glow up plan for no other reason than you deserve it. My 2-Year Glow Up Plan Phase 1: Foundation Getting crystal clear on my vision, doing a mental and physical health reset and getting to the root of any underlying issues, and decluttering my laife to audit out anything that doesn't align. Phase 2: Expansion Elevating my routines, style, finances, and community in order to live with intention, curate a life that looks like my vision board, and romanticize my life. Phase 3: Reinvention Focus on my purpose and passion, get in touch with and learn to trust my intuition and decision making, set boundaries and enforce them, and become the most confident version of me. Phase 4: CELEBRATE! My twenties were not exactly what I thought they'd be, they were amazing but for the most part I felt lost. Looking around trying to figure out who I was and where my life should go, but now I am taking charge and deciding to make my life into what I want it to be.  FREE Goal Setting Guide Daily Planning Notepad

Freundschaften sind die wichtigsten Beziehungen im Leben, das sagen Experten und Glücksforscher. Wo auch immer etwas mies läuft, in der Familie, im Job, in der Liebesbeziehung, es sind Freunde, die Dich auffangen. Zuhören, da sind, mit Dir etwas unternehmen. Und für die Du da sein kannst. Es ist wertvoll, vertraute, loyale Freunde zu finden, und das geht zu jedem Zeitpunkt im Leben! Auch im hohen Alter kann man noch die beste Freundin finden. Vielen fällt das allerdings schwer und sie haben viele Enttäuschungen erlebt. Ich erzähle Euch von einer Phase in meiner Kindheit/Jugend, die auch mir großen Schmerz verursacht hat. Ich konnte auf jeden Fall Jahre nicht darüber nachdenken. Was genau passiert ist in meiner Zeit im Schwimmverein, davon erzähle ich in dieser Folge. Es lohnt sich, in schwierigen Zeiten darauf zu vertrauen, dass es wieder besser wird. Und das aktiv zu betreiben! Manchmal muss man Unbehagen aushalten. Diesen Satz hat jemand zu mir gesagt, und er ist wahr! Denn das ist besser, als ein unangenehmes Gefühl direkt zu übertünchen und sich in etwas Halbgutes zu stürzen. Unbehagen aushalten, an besseren Zeiten arbeiten, den Rest übernimmt das Universum. Hört rein in die 50. Folge!

This week Jordan and Lyndsey wrap up the series WandaVision, join us as we close out this series but open up Phase 4 of the MCU!

Braves split the 4-game series with the Mets in NYC after the bats go quiet and the Braves get shut out 4-0. Barrett Sallee joined The Locker Room and talked about the loss, Ronald Acuna Jr making it to Phase 2 of All Star voting and the Phillies coming to town Braves return home to face the Phillies for a 3-game weekend series tonight 6p Ford Leadoff Show 7:15p First Pitch. Bryce Elder (2-4, 4.77) will face off against Mick Abel (2-1, 3.47), Hear Atlanta Braves Today every weekday morning during The Locker Room at 7:45aSee omnystudio.com/listener for privacy information.

Steve Gruber discusses news and headlines

Dr. Diwakar Davar and Dr. Jason Luke discuss novel agents in melanoma and other promising new data in the field of immunotherapy that were presented at the 2025 ASCO Annual Meeting. TRANSCRIPT Dr. Diwakar Davar: Hello. My name is Diwakar Davar, and I am welcoming you to the ASCO Daily News Podcast. I'm an associate professor of medicine and the clinical director of the Melanoma and Skin Cancer Program at the University of Pittsburgh's Hillman Cancer Center. Today, I'm joined by my colleague and good friend, Dr. Jason Luke. Dr. Luke is a professor of medicine. He is also the associate director of clinical research and the director of the Phase 1 IDDC Program at the University of Pittsburgh's Hillman Cancer Center. He and I are going to be discussing some key advancements in melanoma and skin cancers that were presented at the 2025 ASCO Annual Meeting. Our full disclosures are available in the transcript of this episode.  Jason, it is great to have you back on the podcast. Dr. Jason Luke: Thanks again so much for the opportunity, and I'm really looking forward to it. Dr. Diwakar Davar: Perfect. So we will go ahead and start talking a little bit about a couple of key abstracts in both the drug development immunotherapy space and the melanoma space. The first couple of abstracts, the first two, will cover melanoma. So, the first is LBA9500, which was essentially the primary results of RELATIVITY-098. RELATIVITY-098 was a phase 3 trial that compared nivolumab plus relatlimab in a fixed-dose combination against nivolumab alone for the adjuvant treatment of resected high-risk disease. Jason, do you want to maybe give us a brief context of what this is? Dr. Jason Luke: Yeah, it's great, thanks. So as almost all listeners, of course, will be aware, the use of anti–PD-1 immunotherapies really revolutionized melanoma oncology over the last 10 to 15 years. And it has become a standard of care in the adjuvant setting as well. But to review, in patients with stage III melanoma, treatment can be targeted towards BRAF with BRAF and MEK combination therapy, where that's relevant, or anti–PD-1 with nivolumab or pembrolizumab are a standard of care. And more recently, we've had the development of neoadjuvant approaches for palpable stage III disease. And in that space, if patients present, based on two different studies, either pembrolizumab or nivolumab plus ipilimumab can be given prior to surgery for somewhere in the 6- to 9-week range. And so all of these therapies have improved time-to-event endpoints, such as relapse-free or event-free survival. It's worth noting, however, that despite those advances, we've had a couple different trials now that have actually failed in this adjuvant setting, most high profile being the CheckMate-915 study, which looked at nivolumab plus ipilimumab and unfortunately was a negative study. So, with RELATIVITY-047, which was the trial of nivolumab plus relatlimab that showed an improvement in progression-free survival for metastatic disease, there's a lot of interest, and we've been awaiting these data for a long time for RELATIVITY-098, which, of course, is this adjuvant trial of LAG-3 blockade with relatlimab plus nivolumab. Dr. Diwakar Davar: Great. So with that, let's briefly discuss the trial design and the results. So this was a randomized, phase 3, blinded study, so double-blinded, so neither the investigators knew what the patients were getting, nor did the patients know what they were getting. The treatment investigational arm was nivolumab plus relatlimab in the fixed-dose combination. So that's the nivolumab standard fixed dose with relatlimab that was FDA approved in RELATIVITY-047. And the control arm was nivolumab by itself. The duration of treatment was 1 year. The patient population consisted of resected high-risk stage III or IV patients. The primary endpoint was investigator-assessed RFS. Stage and geography were the standard stratifying factors, and they were included, and most of the criteria were balanced across both arms. What we know at this point is that the 2-year RFS rate was 64% and 62% in the nivolumab and nivolumab-combination arms, respectively. The 2-year DMFS rate was similarly equivalent: 76% with nivolumab monotherapy, 73% with the combination. And similar to what you had talked about with CheckMate 915, unfortunately, the addition of LAG-3 did not appear to improve the RFS or DMFS compared to control in this patient population. So, tell us a little bit about your take on this and what do you think might be the reasons why this trial was negative? Dr. Jason Luke: It's really unfortunate that we have this negative phase 3 trial. There had been a lot of hope that the combination of nivolumab with relatlimab would be a better tolerated combination that increased the efficacy. So in the metastatic setting, we do have 047, the study that demonstrated nivolumab plus relatlimab, but now we have this negative trial in the adjuvant setting. And so as to why exactly, I think is a complicated scenario. You know, when we look at the hazard ratios for relapse-free survival, the primary endpoint, as well as the secondary endpoints for distant metastasis-free survival, we see that the hazard ratio is approximately 1. So there's basically no difference. And that really suggests that relatlimab in this setting had no impact whatsoever on therapeutic outcomes in terms of efficacy. Now, it's worth noting that there was a biomarker subanalysis that was presented in conjunction with these data that looked at some immunophenotyping, both from circulating T cells, CD8 T cells, as well as from the tumor microenvironment from patients who were treated, both in the previous metastatic trial, the RELATIVITY-047 study, and now in this adjuvant study in the RELATIVITY-098 study. And to briefly summarize those, what was identified was that T cells in advanced melanoma seemed to have higher expression levels of LAG-3 relative to T cells that are circulating in patients that are in the adjuvant setting. In addition to that, there was a suggestion that the magnitude of increase is greater in the advanced setting versus adjuvant. And the overall summary of this is that the suggested rationale for why this was a negative trial may have been that the target of LAG-3 is not expressed as highly in the adjuvant setting as it is in the metastatic setting. And so while the data that were presented, I think, support this kind of an idea, I am a little bit cautious that this is actually the reason for why the trial was negative, however. I would say we're not really sure yet as to why the trial was negative, but the fact that the hazard ratios for the major endpoints were essentially 1 suggests that there was no impact whatsoever from relatlimab. And this really makes one wonder whether or not building on anti–PD-1 in the adjuvant setting is feasible because anti–PD-1 works so well. You would think that even if the levels of LAG-3 expression were slightly different, you would have seen a trend in one direction or another by adding a second drug, relatlimab, in this scenario. So overall, I think it's an unfortunate circumstance that the trial is negative. Clearly there's going to be no role for relatlimab in the adjuvant setting. I think this really makes one wonder about the utility of LAG-3 blockade and how powerful it really can be. I think it's probably worth pointing out there's another adjuvant trial ongoing now of a different PD-1 and LAG-3 combination, and that's cemiplimab plus fianlimab, a LAG-3 antibody that's being dosed from another trial sponsor at a much higher dose, and perhaps that may make some level of difference. But certainly, these are unfortunate results that will not advance the field beyond where we were at already. Dr. Diwakar Davar: And to your point about third-generation checkpoint factors that were negative, I guess it's probably worth noting that a trial that you were involved with, KeyVibe-010, that evaluated the PD-1 TIGIT co-formulation of vibostolimab, MK-4280A, was also, unfortunately, similarly negative. So, to your point, it's not clear that all these third-generation receptors are necessarily going to have the same impact in the adjuvant setting, even if they, you know, for example, like TIGIT, and they sometimes may not even have an effect at all in the advanced cancer setting. So, we'll see what the HARMONY phase 3 trial, that's the Regeneron cemiplimab/fianlimab versus pembrolizumab control with cemiplimab with fianlimab at two different doses, we'll see how that reads out. But certainly, as you've said, LAG-3 does not, unfortunately, appear to have an impact in the adjuvant setting. So let's move on to LBA9501. This is the primary analysis of EORTC-2139-MG or the Columbus-AD trial. This was a randomized trial of encorafenib and binimetinib, which we will abbreviate as enco-bini going forward, compared to placebo in high-risk stage II setting in melanoma in patients with BRAF V600E or K mutant disease. So Jason, you know, you happen to know one or two things about the resected stage II setting, so maybe contextualize the stage II setting for us based on the trials that you've led, KEYNOTE-716, as well as CheckMate-76K, set us up to talk about Columbus-AD. Dr. Jason Luke: Thanks for that introduction, and certainly stage II disease has been something I've worked a lot on. The rationale for that has been that building off of the activity of anti–PD-1 in metastatic melanoma and then seeing the activity in stage III, like we just talked about, it was a curious circumstance that dating back about 7 to 8 years ago, there was no availability to use anti–PD-1 for high-risk stage II patients, even though the risk of recurrence and death from melanoma in the context of stage IIB and IIC melanoma is in fact similar or actually higher than in stage IIIA or IIIB, where anti–PD-1 was approved. And in that context, a couple of different trials that you alluded to, the Keynote-716 study that I led, as well as the CheckMate 76K trial, evaluated pembrolizumab and nivolumab, respectively, showing an improvement in relapse-free and distant metastasis-free survival, and both of those agents have subsequently been approved for use in the adjuvant setting by the US FDA as well as the European Medicines Agency.  So bringing then to this abstract, throughout melanoma oncology, we've seen that the impact of anti–PD-1 immunotherapy versus BRAF and MEK-targeted therapy have had very similar outcomes on a sort of comparison basis, both in frontline metastatic and then in adjuvant setting. So it was a totally reasonable question to ask: Could we use adjuvant BRAF and MEK inhibitor therapy? And I think all of us expected the answer would be yes. As we get into the discussion of the trial, I think the unfortunate circumstance was that the timing of this clinical trial being delayed somewhat, unfortunately, made it very difficult to accrue the trial, and so we're going to have to try to read through the tea leaves sort of, based on only a partially complete data set. Dr. Diwakar Davar: So, in terms of the results, they wanted to enroll 815 patients, they only enrolled 110. The RFS and DMFS were marginally improved in the treatment arm but certainly not significantly, which is not surprising because the trial had only accrued 16% to 18% of its complete accrual. As such, we really can't abstract from the stage III COMBI-AD data to stage II patients. And certainly in this setting, one would argue that the primary treatment options certainly remain either anti–PD-1 monotherapy, either with pembrolizumab or nivolumab, based on 716 or 76K, or potentially active surveillance for the patients who are not inclined to get treated.  Can you tell us a little bit about how you foresee drug development going forward in this space because, you know, for example, with HARMONY, certainly IIC disease is a part of HARMONY. We will know at least a little bit about that in this space. So what do you think about the stage IIB/C patient population? Is this a patient population in which future combinations are going to be helpful, and how would you think about where we can go forward from here? Dr. Jason Luke: It is an unfortunate circumstance that this trial could not be accrued at the pace that was necessary. I think all of us believe that the results would have been positive if they'd been able to accrue the trial. In the preliminary data set that they did disclose of that 110 patients, you know, it's clear there is a difference at a, you know, a landmark at a year. They showed a 16% difference, and that would be in line with what has been seen in stage III. And so, you know, I think it's really kind of too bad. There's really going to be no regulatory approach for this consideration. So using BRAF and MEK inhibition in stage II is not going to be part of standard practice moving into the future. To your point, though, about where will the field go? I think what we're already realizing is that in the adjuvant setting, we're really overtreating the total population. And so beyond merely staging by AJCC criteria, we need to move to biomarker selection to help inform which patients truly need the treatment. And in that regard, I don't think we've crystallized together as a field as yet, but the kinds of things that people are thinking about are the integration of molecular biomarkers like ctDNA. When it's positive, it can be very helpful, but in melanoma, we found that, unfortunately, the rates are quite low, you know, in the 10% to 15% range in the adjuvant setting. So then another consideration would be factors in the primary tumor, such as gene expression profiling or other considerations.  And so I think the future of adjuvant clinical trials will be an integration of both the standard AJCC staging system as well as some kind of overlaid molecular biomarker that helps to enrich for a higher-risk population of patients because on a high level, when you abstract out, it's just clearly the case that we're rather substantially overtreating the totality of the population, especially given that in all of our adjuvant studies to date for anti–PD-1, we have not yet shown that there's an overall survival advantage. And so some are even arguing perhaps we should even reserve treatment until patients progress. I think that's a complicated subject, and standard of care at this point is to offer adjuvant therapy, but certainly a lot more to do because many patients, you know, unfortunately, still do progress and move on to metastatic disease. Dr. Diwakar Davar: Let's transition to Abstract 2508. So we're moving on from the melanoma to the novel immunotherapy abstracts. And this is a very, very, very fascinating drug. It's IMA203. So Abstract 2508 is a phase 1 clinical update of IMA203. IMA203 is an autologous TCR-T construct targeting PRAME in patients with heavily pretreated PD-1-refractory metastatic melanoma. So Jason, in the PD-1 and CTLA-4-refractory settings, treatment options are either autologous TIL, response rate, you know, ballpark 29% to 31%, oncolytic viral therapy, RP1 with nivolumab, ORR about 30-ish percent. So new options are needed. Can you tell us a little bit about IMA203? Perhaps tell us for the audience, what is the difference between a TCR-T and traditional autologous TIL? And a little bit about this drug, IMA203, and how it distinguishes itself from the competing TIL products in the landscape. Dr. Jason Luke: I'm extremely enthusiastic about IMA203. I think that it really has transformative potential based on these results and hopefully from the phase 3 trial that's open to accrual now. So, what is IMA203? We said it's a TCR-T cell product. So what that means is that T cells are removed from a patient, and then they can be transduced through various technologies, but inserted into those T cells, we can then add a T-cell receptor that's very specific to a single antigen, and in this case, it's PRAME. So that then is contrasted quite a bit from the TIL process, which includes a surgical resection of a tumor where T cells are removed, but they're not specific necessarily to the cancer, and they're grown up in the lab and then given to the patient. They're both adoptive cell transfer products, but they're very different. One is genetically modified, and the other one is not. And so the process for generating a TCR-T cell is that patients are required to have a new biomarker that some may not be familiar with, which is HLA profiling. So the T-cell receptor requires matching to the concomitant HLA for which the peptide is bound in. And so the classic one that is used in most oncology practices is A*02:01 because approximately 48% of Caucasians have A*02:01, and the frequency of HLA in other ethnicities starts to become highly variable. But in patients who are identified to have A*02:01 genotype, we can then remove blood via leukapheresis or an apheresis product, and then insert via lentiviral transduction this T-cell receptor targeting PRAME. Patients are then brought back to the hospital where they can receive lymphodepleting chemotherapy and then receive the reinfusion of the TCR-T cells. Again, in contrast with the TIL process, however, these T cells are extremely potent, and we do not need to give high-dose interleukin-2, which is administered in the context of TIL. Given that process, we have this clinical trial in front of us now, and at ASCO, the update was from the phase 1 study, which was looking at IMA203 in an efficacy population of melanoma patients who were refractory at checkpoint blockade and actually multiple lines of therapy. So here, there were 33 patients and a response rate of approximately 50% was observed in this population of patients, notably with a duration of response approximately a year in that treatment group. And I realize that these were heavily pretreated patients who had a range of very high-risk features. And approximately half the population had uveal melanoma, which people may be aware is a generally speaking more difficult-to-treat subtype of melanoma that metastasizes to the liver, which again has been a site of resistance to cancer immunotherapy. So these results are extremely promising. To summarize them from what I said, it's easier to make TCR-T cells because we can remove blood from the patient to transduce the T cells, and we don't have to put them through surgery. We can then infuse them, and based on these results, it looks like the response rate to IMA203 is a little bit more than double what we expect from lifileucel. And then, whereas with lifileucel or TILs, we have to give high-dose IL-2, here we do not have to give high-dose IL-2. And so that's pretty promising. And a clinical trial is ongoing now called the SUPREME phase 3 clinical trial, which is hoping to validate these results in a randomized global study. Dr. Diwakar Davar: Now, one thing that I wanted to go over with you, because you know this trial particularly well, is what you think of the likelihood of success, and then we'll talk a little bit about the trial design. But in your mind, do you think that this is a trial that has got a reasonable likelihood of success, maybe even a high likelihood of success? And maybe let's contextualize that to say an alternative trial, such as, for example, the TebeAM trial, which is essentially a T-cell bispecific targeting GP100. It's being compared against SOC, investigator's choice control, also in a similarly heavily pretreated patient population. Dr. Jason Luke: So both trials, I think, have a strong chance of success. They are very different kinds of agents. And so the CD3 bispecific that you referred to, tebentafusp, likely has an effect of delaying progression, which in patients with advanced disease could have a value that might manifest as overall survival. With TCR-T cells, by contrast, we see a very high response rate with some of the patients going into very durable long-term benefit. And so I do think that the SUPREME clinical trial has a very high chance of success. It will be the first clinical trial in solid tumor oncology randomizing patients to receive a cell therapy as compared with a standard of care. And within that standard of care control arm, TILs are allowed as a treatment. And so it will also be the first study that will compare TCR-T cells against TILs in a randomized phase 3. But going back to the data that we've seen in the phase 1 trial, what we observe is that the duration of response is really connected to the quality of the response, meaning if you have more than a 50% tumor shrinkage, those patients do very, very well. But even in patients who have less than 50% tumor shrinkage, the median progression-free survival right now is about 4.5 months. And again, as we think about trial design, standard of care options for patients who are in this situation are unfortunately very bad. And the progression-free survival in that population is probably more like 2 months. So this is a trial that has a very high likelihood of being positive because the possibility of long-term response is there, but even for patients who don't get a durable response, they're likely going to benefit more than they would have based on standard chemotherapy or retreatment with an anti–PD-1 agent. Dr. Diwakar Davar: Really, a very important trial to enroll, a trial that is first in many ways. First of a new generation of TCR-T agents, first trial to look at cell therapy in the control arm, a new standard of efficacy, but potentially also if this trial is successful, it will also be a new standard of trial conduct, a new kind of trial, of a set of trials that will be done in the second-line immunotherapy-refractory space. So let's pivot to the last trial that we were going to discuss, which was Abstract 2501. Abstract 2501 is a first-in-human phase 1/2 trial evaluating BNT142, which is the first-in-class mRNA-encoded bispecific targeting Claudin-6 and CD3 in patients with Claudin-positive tumors. We'll talk a little bit about this, but maybe let's start by talking a little bit about Claudin-6. So Claudin-6 is a very interesting new target. It's a target that's highly expressed in GI and ovarian tumors. There are a whole plethora of Claudin-6-targeting agents, including T-cell bispecifics and Claudin-6-directed CAR-Ts that are being developed. But BNT142 is novel. It's a novel lipid nanoparticle LNP-encapsulated mRNA. The mRNA encodes an anti–Claudin-6 CD3 bispecific termed RiboMAB-021. And it then is administered to the patient. The BNT142-encoding mRNA LNPs are taken up by the liver and translated into the active drug. So Jason, tell us a little bit about this agent. Why you think it's novel, if you think it's novel, and let's talk a little bit then about the results. Dr. Jason Luke: So I certainly think this is a novel agent, and I think this is just the first of what will probably become a new paradigm in oncology drug development. And so you alluded to this, but just to rehash it quickly, the drug is encoded as genetic information that's placed in the lipid nanoparticle and then is infused into the patient. And after the lipid nanoparticles are taken up by the liver, which is the most common place that LNPs are usually taken up, that genetic material in the mRNA starts to be translated into the actual protein, and that protein is the drug. So this is in vivo generation, so the patient is making their own drug inside their body. I think it's a really, really interesting approach. So for any drug that could be encoded as a genetic sequence, and in this case, it's a bispecific, as you mentioned, CD3-Claudin-6 engager, this could have a tremendous impact on how we think about pharmacology and novel drug development moving into the future in oncology. So I think it's an extremely interesting drug, the like of which we'll probably see only more moving forward. Dr. Diwakar Davar: Let's maybe briefly talk about the results. You know, the patient population was heavily pretreated, 65 or so patients, mostly ovarian cancer. Two-thirds of the patients were ovarian cancer, the rest were germ cell and lung cancer patients. But let's talk a little bit about the efficacy. The disease control rate was about 58% in the phase 1 population as a whole, but 75% in the ovarian patient population. Now tell us a little bit about the interesting things about the drug in terms of the pharmacokinetics, and also then maybe we can pivot to the clinical activity by dose level. Dr. Jason Luke: Well, so they did present in their presentation at ASCO a proportionality showing that as higher doses were administered, that greater amounts of the drug were being made inside the patient. And so that's an interesting observation, and it's an important one, right? Suggesting that the pharmacology that we classically think of by administering drugs by IV, for example, would still be in play. And that did translate into some level of efficacy, particularly at the higher dose levels. Now, the caveat that I'll make a note of is that disease control rate is an endpoint that I think we have to be careful about because what that really means is sometimes a little bit unclear. Sometimes patients have slowly growing tumors and so on and so forth. And the clinical relevance of disease control, if it doesn't last at least 6 months, I think is probably pretty questionable. So I think these are extremely interesting data, and there's some preliminary sense that getting the dose up is going to matter because the treatment responses were mostly observed at the highest dose levels. There's also a caveat, however, that across the field of CD3 bispecific molecules like this, there's been quite a bit of heterogeneity in terms of the response rate, with some of them only really generating stable disease responses and other ones having more robust responses. And so I think this is a really interesting initial foray into this space. My best understanding is this molecule is not moving forward further after this, but I think that this really does set it up to be able to chase after multiple different drug targets on a CD3 bispecific backbone, both in ovarian cancer, but then basically across all of oncology. Dr. Diwakar Davar: Perfect. This is a very new sort of exciting arena where we're going to be looking at, in many ways, these programmable constructs, whether we're looking at in vivo-generated, in this case, a T-cell bispecific, but we've also got newer drugs where we are essentially giving drugs where people are generating in vivo CAR T, and also potentially even in vivo TCR-T. But certainly lots of new excitement around this entire class of drugs. And so, what we'd like to do at this point in time is switch to essentially the fact that we've got a very, very exciting set of data at ASCO 2025. You've heard from Dr. Luke regarding the advances in both early drug development but also in advanced cutaneous melanoma. And Jason, as always, thank you so much for sharing your very valuable and great, fantastic insights with us on the ASCO Daily News Podcast. Dr. Jason Luke: Well, thanks again for the opportunity. Dr. Diwakar Davar: And thank you to our listeners for taking your time to listen today. You will find the links to the abstracts that we discussed today in the transcript of this episode. And finally, if you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:    Dr. Diwakar Davar    @diwakardavar    Dr. Jason Luke @jasonlukemd Follow ASCO on social media:     @ASCO on Twitter       ASCO on Bluesky   ASCO on Facebook       ASCO on LinkedIn   Disclosures:     Dr. Diwakar Davar:      Honoraria: Merck, Tesaro, Array BioPharma, Immunocore, Instil Bio, Vedanta Biosciences     Consulting or Advisory Role: Instil Bio, Vedanta Biosciences     Consulting or Advisory Role (Immediate family member): Shionogi     Research Funding: Merck, Checkmate Pharmaceuticals, CellSight Technologies, GSK, Merck, Arvus Biosciences, Arcus Biosciences     Research Funding (Inst.): Zucero Therapeutics     Patents, Royalties, Other Intellectual Property: Application No.: 63/124,231 Title: COMPOSITIONS AND METHODS FOR TREATING CANCER Applicant: University of Pittsburgh–Of the Commonwealth System of Higher Education Inventors: Diwakar Davar Filing Date: December 11, 2020 Country: United States MCC Reference: 10504-059PV1 Your Reference: 05545; and Application No.: 63/208,719 Enteric Microbiotype Signatures of Immune-related Adverse Events and Response in Relation to Anti-PD-1 Immunotherapy     Dr. Jason Luke:     Stock and Other Ownership Interests: Actym Therapeutics, Mavu Pharmaceutical, Pyxis, Alphamab Oncology, Tempest Therapeutics, Kanaph Therapeutics, Onc.AI, Arch Oncology, Stipe, NeoTX     Consulting or Advisory Role: Bristol-Myers Squibb, Merck, EMD Serono, Novartis, 7 Hills Pharma, Janssen, Reflexion Medical, Tempest Therapeutics, Alphamab Oncology, Spring Bank, Abbvie, Astellas Pharma, Bayer, Incyte, Mersana, Partner Therapeutics, Synlogic, Eisai, Werewolf, Ribon Therapeutics, Checkmate Pharmaceuticals, CStone Pharmaceuticals, Nektar, Regeneron, Rubius, Tesaro, Xilio, Xencor, Alnylam, Crown Bioscience, Flame Biosciences, Genentech, Kadmon, KSQ Therapeutics, Immunocore, Inzen, Pfizer, Silicon Therapeutics, TRex Bio, Bright Peak, Onc.AI, STipe, Codiak Biosciences, Day One Therapeutics, Endeavor, Gilead Sciences, Hotspot Therapeutics, SERVIER, STINGthera, Synthekine     Research Funding (Inst.): Merck , Bristol-Myers Squibb, Incyte, Corvus Pharmaceuticals, Abbvie, Macrogenics, Xencor, Array BioPharma, Agios, Astellas Pharma , EMD Serono, Immatics, Kadmon, Moderna Therapeutics, Nektar, Spring bank, Trishula, KAHR Medical, Fstar, Genmab, Ikena Oncology, Numab, Replimmune, Rubius Therapeutics, Synlogic, Takeda, Tizona Therapeutics, Inc., BioNTech AG, Scholar Rock, Next Cure     Patents, Royalties, Other Intellectual Property: Serial #15/612,657 (Cancer Immunotherapy), and Serial #PCT/US18/36052 (Microbiome Biomarkers for Anti-PD-1/PD-L1 Responsiveness: Diagnostic, Prognostic and Therapeutic Uses Thereof)     Travel, Accommodations, Expenses: Bristol-Myers Squibb, Array BioPharma, EMD Serono, Janssen, Merck, Novartis, Reflexion Medical, Mersana, Pyxis, Xilio

Braves split the 4-game series with the Mets in NYC after the bats go quiet and the Braves get shut out 4-0. Barrett Sallee joined The Locker Room and talked about the loss, Ronald Acuna Jr making it to Phase 2 of All Star voting and the Phillies coming to town Braves return home to face the Phillies for a 3-game weekend series tonight 6p Ford Leadoff Show 7:15p First Pitch. Bryce Elder (2-4, 4.77) will face off against Mick Abel (2-1, 3.47), Hear Atlanta Braves Today every weekday morning during The Locker Room at 7:45aSee omnystudio.com/listener for privacy information.

Dr. Neeraj Agarwal and Dr. Jeanny Aragon-Ching discuss important advances in the treatment of prostate, bladder, and kidney cancers that were presented at the 2025 ASCO Annual Meeting. TRANSCRIPT Dr. Neeraj Agarwal: Hello, and welcome to the ASCO Daily News Podcast. I am Dr. Neeraj Agarwal, your guest host of the ASCO Daily News Podcast today. I am the director of the Genitourinary Oncology Program and a professor of medicine at the University of Utah Huntsman Cancer Institute and editor-in-chief of the ASCO Daily News.  I am delighted to be joined by Dr. Jeanny Aragon-Ching, a GU medical oncologist and the clinical program director of the GU Center at the Inova Schar Cancer Institute in Virginia. Today, we will be discussing some key abstracts in GU oncology that were presented at the 2025 ASCO Annual Meeting.  Our full disclosures are available in the transcript of this episode.  Jeanny, it is great to have you on the podcast. Dr. Jeanny Aragon-Ching: Oh, thank you so much, Neeraj. Dr. Neeraj Agarwal: Jeanny, let's begin with some prostate cancer abstracts. Let's begin with Abstract 5017 titled, “Phase 1 study results of JNJ-78278343 (pasritamig) in metastatic castration-resistant prostate cancer.” Can you walk us through the design and the key findings of this first-in-human trial? Dr. Jeanny Aragon-Ching: Yeah, absolutely, Neeraj. So this study, presented by Dr. Capucine Baldini, introduces pasritamig, a first-in-class T-cell redirecting bispecific antibody that simultaneously binds KLK2 on prostate cancer cells and CD3 receptor complexes on T cells. KLK2 is also known as human kallikrein 2, which is selectively expressed in prostate tissue. And for reference, KLK3 is what we now know as the PSA, prostate-specific antigen, therefore making it an attractive and specific target for therapeutic engagement. Now, while this was an early, first-in-human, phase 1 study, it enrolled 174 heavily pretreated metastatic CRPC patients. So many were previously treated with ARPIs, taxanes, and radioligand therapy. So given the phase 1 nature of this study, the primary objective was to determine the safety and the RP2D, which is the recommended phase 2 dose. Secondary objectives included preliminary assessment of antitumor activity. So, pasritamig was generally well tolerated. There were no treatment-related deaths. Serious adverse events were rare. And in the RP2D safety cohort, where patients received the step-up dosing up to 300 mg of IV every 6 weeks, the most common treatment-related adverse events were low-grade infusion reactions. There was fatigue and grade 1 cytokine release syndrome, what we call CRS. And no cases of neurotoxicity, or what we call ICANS, the immune effector cell-associated neurotoxicity syndrome, reported. Importantly, the CRS occurred in just about 8.9% of patients. All were grade 1. No patients required tocilizumab or discontinued treatment due to adverse events. So, this suggests a favorable safety profile, allowing hopefully for outpatient administration without hospitalization, which will be very important when we're thinking about bispecifics moving forward. In terms of efficacy, pasritamig showed promising activity. About 42.4% of evaluable patients achieved a PSA50 response. Radiographic PFS was about 6.8 months. And among patients with measurable disease, the objective response rate was about 16.1% in those with lymph node or bone metastases, and about 3.7% in those with visceral disease, with a median duration of response of about 11.3 months. So, altogether, this data suggests that pasritamig may offer a well-tolerated and active new potential option for patients with metastatic CRPC.   Again, as a reminder, with the caveat that this is still an early phase 1 study. Dr. Neeraj Agarwal: Thank you, Jeanny. These are promising results for a bispecific T-cell engager, pasritamig, in prostate cancer. I agree, the safety and durability observed here stand out, and this opens the door for further development, possibly even in earlier disease settings.  So, shifting now from immunotherapy to the evolving role of genomics in prostate cancer. So let's discuss Abstract 5094, a real-world, retrospective analysis exploring the prognostic impact of homologous recombination repair gene mutations, especially BRCA1 and BRCA2 mutations, in metastatic hormone-sensitive prostate cancer. Can you tell us more about this abstract, Jeanny? Dr. Jeanny Aragon-Ching: Sure, Neeraj. So this study was presented by Dr. David Olmos, represents one of the largest real-world analyses we have evaluating the impact of homologous recombination repair, or what we would call HRR, alterations in metastatic hormone-sensitive prostate cancer. So, this cohort included 556 men who underwent paired germline and somatic testing. Now, about 30% of patients had HRR alterations, with about 12% harboring BRCA1 or BRCA2 mutations and 16% having alterations in other HRR genes. Importantly, patients were stratified via CHAARTED disease volume, and outcomes were examined across treatment approaches, including ADT alone, doublet therapy, and triplet therapy. The prevalence of BRCA and HRR alterations were about similar between the metastatic hormone-sensitive prostate cancer and the metastatic castrate-resistant prostate cancer, with no differences observed, actually, between the patients with high volume versus low volume disease.  So, the key finding was that BRCA and HRR alterations were associated with poor clinical outcomes in metastatic hormone-sensitive prostate cancer. And notably, the impact of these alterations may actually be even greater in metastatic hormone-sensitive prostate cancer than previously reported in metastatic CRPC. So, the data showed that when BRCA mutations are present, the impact of the volume of disease is actually limited. So, poor outcomes were observed across the board for both high-volume and low-volume groups. So, the analysis showed that patients with HRR alterations had significantly worse outcomes compared to patients without HRR alterations. Median radiographic progression-free survival was about 20.5 months for the HRR-altered patients versus 30.6 months for the non-HRR patients, with a hazard ratio of 1.6. Median overall survival was 39 months for HRR-altered patients compared to 55.7 months for the non-HRR patients, with a hazard ratio of 1.5. Similar significant differences were observed when BRCA-mutant patients were compared with patients harboring non-BRCA HRR mutations. Overall, poor outcomes were independent of treatment of ARPI or taxanes. Dr. Neeraj Agarwal: Thank you, Jeanny. So, these data reinforce homologous recombination repair mutations as both a predictive and prognostic biomarker, not only in the mCRPC, but also in the metastatic hormone-sensitive setting as well. It also makes a strong case for incorporating genomic testing early in the disease course and not waiting until our patients have castration-resistant disease. Dr. Jeanny Aragon-Ching: Absolutely, Neeraj. And I think this really brings home the point and the lead up to the AMPLITUDE trial, which is LBA5006, a phase 3 trial that builds on this very concept of testing with a PARP inhibitor, niraparib, in the hormone-sensitive space. Can you tell us a little bit more about this abstract, Neeraj? Dr. Neeraj Agarwal: Sure. So, the AMPLITUDE trial, a phase 3 trial presented by Dr. Gerhardt Attard, enrolled 696 patients with metastatic hormone-sensitive prostate cancer and HRR gene alterations. 56% of these patients had BRCA1 and BRCA2 mutations. Patients were randomized to receive abiraterone with or without niraparib, a PARP inhibitor. The majority of patients, 78% of these patients, had high-volume metastatic hormone-sensitive prostate cancer, and 87% of these patients had de novo metastatic HSPC. And 16% of these patients received prior docetaxel, which was allowed in the clinical trial. So, with a median follow-up of nearly 31 months, radiographic progression-free survival was significantly prolonged with the niraparib plus abiraterone combination, and median was not reached in this arm, compared to abiraterone alone, which was 29.5 months, with a hazard ratio of 0.63, translating to a 37% reduction in risk of progression or death. This benefit was even more pronounced in the BRCA1 and BRCA2 subgroup, with a 48% reduction in risk of progression, with a hazard ratio of 0.52. Time to symptomatic progression also improved significantly across all patients, including patients with BRCA1, BRCA2, and HRR mutations. Although overall survival data remain immature, early trends favored the niraparib plus abiraterone combination. The safety profile was consistent with prior PARP inhibitor studies, with grade 3 or higher anemia and hypertension were more common but manageable. Treatment discontinuation due to adverse events remained low at 11%, suggesting that timely dose modifications when our patients experience grade 3 side effects may allow our patients to continue treatment without discontinuation. These findings support niraparib plus abiraterone as a potential new standard of care in our patients with metastatic hormone-sensitive prostate cancer with HRR alterations, and especially in those who had BRCA1 and BRCA2 mutations. Dr. Jeanny Aragon-Ching: Thank you, Neeraj. This trial is especially exciting because it brings PARP inhibitors earlier into the treatment paradigm. Dr. Neeraj Agarwal: Exactly. And it is exciting to see the effect of PARP inhibitors in the earlier setting.  So Jeanny, now let's switch gears a bit to bladder cancer, which also saw several impactful studies. Could you tell us about Abstract 4502, an exploratory analysis from the EV-302 trial, which led to approval of enfortumab vedotin plus pembrolizumab for our patients with newly diagnosed metastatic bladder cancer? So here, the authors looked at the outcomes in patients who achieved a confirmed complete response with EV plus pembrolizumab. Dr. Jeanny Aragon-Ching: Sure, Neeraj. So, EV-302 demonstrated significant improvements in progression-free and overall survival for patients previously treated locally advanced or metastatic urothelial cancer, I'll just call it metastatic UC, as a frontline strategy, establishing EV, which is enfortumab vedotin, plus pembro, with pembrolizumab as standard of care in this setting.  So, this year at ASCO, Dr Shilpa Gupta presented this exploratory responder analysis from the phase 3 EV-302 trial. Among 886 randomized patients, about 30.4% of patients, this is about 133, in the EV+P arm, and 14.5% of the patients in the chemotherapy arm, achieved a confirmed complete response. They call it the CCR rates. So for patients who achieved this, median PFS was not reached with EV+P compared to 26.9 months with chemotherapy, with a hazard ratio of 0.36, translating to a 64% reduction in the risk of progression. Overall survival was also improved. So the median OS was not reached in either arm, but the hazard ratio favored the EV+P at 0.37, translating to a 63% reduction in the risk of death. The median duration of complete response was not reached with EV+P compared to 15.2 months with chemotherapy. And among those patients who had confirmed CRs at 24 months, 78% of patients with the EV+P arm remained progression-free, and around 95% of the patients were alive, compared to 54% of patients who were progression-free and 86% alive of the patients in the chemotherapy arm. Safety among responders were also consistent with prior reports. Grade 3 or higher treatment-related adverse events occurred in 62% of EV+P responders and 72% of chemotherapy responders. Most adverse events were managed with dose modifications, and importantly, no treatment-related deaths were reported among those who were able to achieve complete response.  So these findings further reinforce EV and pembro as the preferred first-line therapy for metastatic urothelial carcinoma, offering a higher likelihood of deep, durable responses with a fairly manageable safety profile. Dr. Neeraj Agarwal: Thank you for the great summary, Jeanny. These findings underscore the depth and durability of responses achievable with this combination and also suggest that achieving a response may be a surrogate for long-term benefit in patients with metastatic urothelial carcinoma.  So now, let's move to Abstract 4503, an exploratory ctDNA analysis from the NIAGARA trial, which evaluated perioperative durvalumab, an immune checkpoint inhibitor, in muscle-invasive bladder cancer. So what can you tell us about this abstract? Dr. Jeanny Aragon-Ching: Absolutely, Neeraj. So, in NIAGARA, presented by Dr. Tom Powles, the addition of perioperative durvalumab to neoadjuvant chemotherapy, gem/cis, significantly improved event-free survival, overall survival, and pathologic complete response in patients with cisplatin-eligible muscle-invasive bladder cancer. Recall that this led to the U.S. FDA approval of this treatment regimen on March 28, 2025.  So, a planned exploratory analysis evaluated the ctDNA dynamics and their association with clinical outcomes, which was the one presented recently at ASCO. So, the study found that the incidence of finding ctDNA positivity in these patients was about 57%. Following neoadjuvant treatment, this dropped to about 22%, with ctDNA clearance being more common in the durvalumab arm, about 41%, compared to the chemotherapy control arm of 31%. Notably, 97% of patients who remained ctDNA positive prior to surgery failed to achieve a pathologic CR. So, this indicates a strong association between ctDNA persistence and lack of tumor eradication. So, postoperatively, only about 9% of patients were ctDNA positive. So, importantly, durvalumab conferred an event-free survival benefit regardless of ctDNA status at both baseline and post-surgery. Among patients who were ctDNA positive at baseline, durvalumab led to a hazard ratio of 0.73 for EFS. So, this translates to a 27% reduction in the risk of disease recurrence, progression, or death compared to the control arm. In the post-surgical ctDNA-positive group, the disease-free survival was also improved with a hazard ratio of 0.49, translating to a 51% reduction in the risk of recurrence.  So, these findings underscore the prognostic value of ctDNA and suggest that durvalumab provides clinical benefit irrespective of molecular residual disease status. So, the data also supports that ctDNA is a promising biomarker for future personalized strategies in the perioperative treatment of muscle-invasive bladder cancer. Dr. Neeraj Agarwal: Thank you, Jeanny. It is great to see that durvalumab is improving outcomes in these patients regardless of ctDNA status. However, based on these data, presence of ctDNA in our patients warrants a closer follow-up with imaging studies, because these patients with positive ctDNA seem to have a higher risk of recurrence. Dr. Jeanny Aragon-Ching: I agree, Neeraj.  Let's round out the bladder cancer discussion with Abstract 4518, which reported the interim results of SURE-02, which is a phase 2 study evaluating neoadjuvant sacituzumab govitecan plus pembrolizumab in cisplatin-ineligible muscle-invasive bladder cancer. Can you tell us more about this abstract, Neeraj? Dr. Neeraj Agarwal: Sure, Jeanny. So, Dr Andrea Necchi presented interim results from the SURE-02 trial. This is a phase 2 study evaluating neoadjuvant sacituzumab govitecan plus pembrolizumab, followed by a response-adapted bladder-sparing treatment and adjuvant pembrolizumab in patients with muscle-invasive bladder cancer.  So, in this interim analysis, 40 patients were treated and 31 patients were evaluable for efficacy. So, the clinical complete response rate was 38.7%. All patients achieving clinical complete response underwent bladder-sparing approach with a repeat TURBT instead of radical cystectomy. Additionally, 51.6% of patients achieved excellent pathologic response with a T stage of 1 or less after neoadjuvant therapy. The treatment was well tolerated, with only 12.9% of patients experiencing grade 3 or higher adverse events without needing dose reduction of sacituzumab. Molecular profiling, interestingly, showed that clinical complete response correlated with luminal and genomically unstable subtypes, while high stromal gene expression was associated with lack of response.  These results suggest that sacituzumab plus pembrolizumab combination has promising activity in this setting, and tolerability, and along with other factors may potentially allow a bladder preservation approach in a substantial number of patients down the line. Dr. Jeanny Aragon-Ching: Yeah, agree with you, Neeraj. And the findings are very provocative and support completing the full trial enrollment and further exploration of this strategy in muscle-invasive bladder cancer in order to improve and provide further bladder-sparing strategies. Dr. Neeraj Agarwal: Agree. So, let's now turn to the kidney cancer, starting with Abstract 4505, the final overall analysis from CheckMate-214 trial, which evaluated nivolumab plus ipilimumab, so dual checkpoint inhibition strategy, versus sunitinib in our patients with metastatic clear cell renal cell carcinoma. Dr. Jeanny Aragon-Ching: Yeah, absolutely, Neeraj. So, the final 9-year analysis of the phase 3 CheckMate-214 trial confirms the long-term superiority of nivolumab and ipilimumab over sunitinib for first-line treatment of advanced metastatic renal cell carcinoma. So, this has a median follow-up of 9 years. Overall survival remains significantly improved with the combination. So, in the ITT patient population, the intention-to-treat, the hazard ratio for overall survival was 0.71. So, this translates to a 29% reduction in the risk of death. 31% of patients were alive at this 108-month follow-up compared to 20% only in those who got sunitinib. So, similar benefits were observed in the intermediate- and poor-risk groups with a hazard ratio of 0.69, and 30% versus 19% survival at 108 months.  Importantly, a delayed benefit was also seen in those favorable-risk patients. So, the hazard ratio for overall survival improved from 1.45 in the initial report and now at 0.8 at 9 years follow-up, with 35% of patients alive at 108 months compared to 22% in those who got sunitinib. Progression-free survival also favored the nivo-ipi arm across all risk groups. At 96 months, the probability of remaining progression-free was about 23% compared to 9% in the sunitinib arm in the ITT patient population, 25% versus 9% in the intermediate- and poor-risk patients, and 13% compared to 11% in the favorable-risk patients. Importantly, at 96 months, 48% of patients in the nivo-ipi responders remained in response compared to just 19% in those who got sunitinib. And in the favorable-risk group, 36% of patients who responded remained in response, although data were not available for sunitinib in this subgroup.  So, this data reinforces the use of nivolumab and ipilimumab as a durable and effective first-line effective strategy for standard of care across all risk groups for advanced renal cell carcinoma. Dr. Neeraj Agarwal: Thank you, Jeanny. And of course, since ipi-nivo data were presented, several other novel ICI-TKI combinations have emerged. And I'm really hoping to see very similar data with TKI-ICI combinations down the line. It is really important to note that we are not seeing any new safety signals with the ICI combinations or ICI-based therapies, which is very reassuring given the extended exposure. Dr. Jeanny Aragon-Ching: Absolutely agree with you there, Neeraj.  Now, going on and moving on to Abstract 4514, which is the KEYNOTE-564 trial, and they reported on the 5-year outcomes of adjuvant pembrolizumab in clear cell RCC in patients who are at high risk for recurrence. Can you tell us a little bit more about this abstract, Neeraj? Dr. Neeraj Agarwal: Sure. So, the KEYNOTE-564 trial established pembrolizumab monotherapy as the first adjuvant regimen to significantly improve both disease-free survival and overall survival compared to placebo after surgery for patients with clear cell renal cell carcinoma. So, Dr Naomi Haas presented the 5-year update from this landmark trial.  A total of 994 patients were randomized to receive either pembrolizumab or placebo. The median follow-up at the time of this analysis was approximately 70 months. Disease-free survival remained significantly improved with pembrolizumab. The median DFS was not reached with pembrolizumab compared to 68.3 months with placebo, with a hazard ratio of 0.71, translating to a 29% reduction in risk of recurrence. At 5 years, 60.9% of patients receiving pembrolizumab remained disease-free compared to 52.2% with placebo. Overall survival also favored pembrolizumab. The hazard ratio for OS was 0.66, translating to a 34% reduction in risk of death, with an estimated 5-year overall survival rate of 87.7% with pembrolizumab compared to 82.3% for placebo. Importantly, these benefits were consistent across all key subgroups, including patients with sarcomatoid features. In addition, no new serious treatment-related adverse events have been reported in the 3 years since treatment completion.  So, these long-term data confirm pembrolizumab as a durable and effective standard adjuvant therapy for patients with resected, high-risk clear cell renal cell carcinoma. Dr. Jeanny Aragon-Ching: Thank you for that wonderful summary, Neeraj. Dr. Neeraj Agarwal: That wraps up our kidney cancer highlights. Any closing thoughts, Jeanny, before we conclude? Dr. Jeanny Aragon-Ching: It's been so wonderful reviewing these abstracts with you, Neeraj. So, the 2025 ASCO Annual Meeting showcased a lot of transformative data across GU cancers, from first-in-class bispecifics to long-term survival in RCC. And these findings are already shaping our clinical practices. Dr. Neeraj Agarwal: I agree. And we have covered a broad spectrum of innovations in GU cancers with strong clinical relevance.  So, thank you, Jeanny, for joining me today and sharing your insights.  And thank you to our listeners for joining us. You will find links to the abstracts discussed today in the transcript of this episode. If you find these conversations valuable, please take a moment to rate, review, and subscribe to the ASCO Daily News Podcast wherever you listen. Thank you so much. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Neeraj Agarwal     @neerajaiims     Dr. Jeanny Aragon-Ching   Follow ASCO on social media:       @ASCO on Twitter       ASCO on Bluesky   ASCO on Facebook       ASCO on LinkedIn       Disclosures:   Dr. Neeraj Agarwal:   Consulting or Advisory Role: Pfizer, Bristol-Myers Squibb, AstraZeneca, Nektar, Lilly, Bayer, Pharmacyclics, Foundation Medicine, Astellas Pharma, Lilly, Exelixis, AstraZeneca, Pfizer, Merck, Novartis, Eisai, Seattle Genetics, EMD Serono, Janssen Oncology, AVEO, Calithera Biosciences, MEI Pharma, Genentech, Astellas Pharma, Foundation Medicine, and Gilead Sciences  Research Funding (Institution): Bayer, Bristol-Myers Squibb, Takeda, Pfizer, Exelixis, Amgen, AstraZeneca, Calithera Biosciences, Celldex, Eisai, Genentech, Immunomedics, Janssen, Merck, Lilly, Nektar, ORIC Pharmaceuticals, Crispr Therapeutics, Arvinas  Dr. Jeanny Aragon-Ching:   Honoraria: Bristol-Myers Squibb, EMD Serono, Astellas Scientific and Medical Affairs Inc., Pfizer/EMD Serono   Consulting or Advisory Role: Algeta/Bayer, Dendreon, AstraZeneca, Janssen Biotech, Sanofi, EMD Serono, MedImmune, Bayer, Merck, Seattle Genetics, Pfizer, Immunomedics, Amgen, AVEO, Pfizer/Myovant, Exelixis,    Speakers' Bureau: Astellas Pharma, Janssen-Ortho, Bristol-Myers Squibb, Astellas/Seattle Genetics

AP's Lisa Dwyer reports on another well known company that is fazing out artificial dyes.

In this episode of the Chasing Clarity: Health & Fitness Podcast, I'm breaking down exactly how I coach Fat Loss Phases to help clients lose body fat, retain muscle, and maintain their results long after the deficit ends.This is the next step in my Health-Centric Coaching Series and it's all about approaching fat loss with intention, strategy, and sustainability.Inside the episode, I cover:⁃ WHY THE GOAL OF FAT LOSS ISN'T JUST WEIGHT LOSS BUT IMPROVING BODY COMPOSITION⁃ HOW I STRUCTURE A FAT LOSS NUTRITION PLAN TO AVOID NUTRIENT DEFICIENCIES⁃ THE IMPORTANCE OF PROTEIN FOR MUSCLE RETENTION, APPETITE REGULATION & THERMOGENESIS⁃ WHY FIBER IS ESSENTIAL FOR SATIETY, METABOLIC HEALTH & LONG-TERM ADHERENCE⁃ THE FOUNDATIONAL HABITS THAT MAKE FAT LOSS PHASES EASIER TO EXECUTE⁃ HOW I COMBINE DIET & TRAINING TO DRIVE BETTER BODY COMPOSITION OUTCOMES⁃ THE NON-NEGOTIABLE ROLE OF RESISTANCE TRAINING IN EVERY FAT LOSS PHASE⁃ HOW I USE CARDIO STRATEGICALLY TO INCREASE ENERGY EXPENDITURE⁃ WHY NEAT & STEP TRACKING ARE CRITICAL TOOLS TO OFFSET ADAPTATION & SUPPORT RESULTS⁃ THE SYSTEMS & BEHAVIORS THAT HELP CLIENTS MAINTAIN RESULTS AFTER THE DIET ENDSIf you've struggled with past fat loss attempts, lost muscle while dieting, or found yourself rebounding once the cut ended, this episode will give you the framework to change that.WHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/For Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiryEmail: Bdacruzfitness@gmail.comBrandon's Website: https://www.brandondacruzfit.com

Jean-François Poulin nous emmène cette semaine dans les coulisses d'un événement UX organisé à Radio-Canada dans le cadre de la Semaine de la découverte. Ce rendez-vous a permis d'aborder le rôle stratégique de la phase de découverte dans le développement de produits numériques, en mettant en lumière une approche structurée, inclusive et centrée sur la valeur. Son entretien avec Sebastien Paccioni révèle comment cette culture se déploie au sein de l'organisation publique, en intégrant toutes les parties prenantes, des designers aux contributeurs éditoriaux. Une démarche qui cherche à éviter les dérives coûteuses et à mieux répondre aux attentes des « citoyens numériques ».

Parents know well the high costs of raising children. Certainly, this affects our ability to save for retirement or meet other financial goals, but what about when our kids leave home? How do empty nesters tend to respond financially, and psychologically? Work from Andrew Biggs, a Senior Fellow at the American Enterprise Institute and author of The Real Retirement Crisis: Why (Almost) Everything You Know About the US Retirement System is Wrong, finds that the period after our children become financially independent can have a big impact on retirement readiness. On this episode of The Behavioral Divide, host Hal Hershfield, discusses the research with Dr. Biggs along with real-world perspective from Certified Financial Planner Robin Sherwood, who serves as a Principal at HTG Investment Advisors. We look at how the empty-nester phase—and life transitions in general—can shape financial choices and personal fulfillment, and what can be done to make both better. The book The Real Retirement Crisis: Why (Almost) Everything You Know About the US Retirement System is Wrong is not affiliated with, sponsored by, or endorsed by Avantis Investors or American Century Investments.  If you enjoy the show, please let us know by giving our series a five-star rating. We'd also love to hear from you. To join in on the discussion, send us a note at BehavioralDivide@AvantisInvestors.com. Important Disclosures The views expressed in this presentation are the speaker's own and not necessarily those of American Century Investments. This presentation is for general information only and is not intended to provide investment, tax or legal advice or recommendations for any particular situation or type of retirement plan. Please consult with a financial, tax or legal advisor on your own particular circumstances. Hal Hershfield is not affiliated with American Century Investments. Follow us on social media: LinkedIn: https://a.vant.is/409KwhI X: https://a.vant.is/3HKHwSL

Today we talk less sleep, more PRs, humidity affecting workouts, missing an important date, and more

In this episode of Challenge Accepted, Frank and Thomas break down the first three episodes of Marvel's Ironheart, now streaming on Disney+. They discuss Riri Williams' return from Wakanda Forever, her emotional and tech-filled journey through Chicago, and her confrontation with Parker Robbins, aka The Hood. The episode dives deep into the show's themes of grief, legacy, and identity, while teasing Mephisto's looming presence in the Marvel Cinematic Universe. With strong performances by Dominique Thorne and Anthony Ramos, the show has potential—despite a rocky rollout and inconsistent writing. This mid-season review also includes predictions, comic book context, and thoughts on how Ironheart fits into Marvel's Phase 5 and beyond. Timestamps and Topics: 00:00:00 Introduction and first impressions 00:00:59 Riri's transition from Wakanda Forever to Ironheart 00:02:37 Chicago setting and the show's authenticity 00:03:36 Emotional honesty in superhero storytelling 00:04:48 Weak writing and underdeveloped supporting characters 00:06:22 Gen Z tone and target audience 00:06:48 Standout performance: Anthony Ramos as The Hood 00:07:32 Natalie's arc and AI consciousness 00:08:21 Episode 2: flashbacks, trauma, and Stark legacy 00:10:12 Stark comparisons and Wakandan tech 00:12:30 Confusion around Zeke and character awkwardness 00:13:44 Episode 3: action, tension, and Mephisto's influence 00:14:53 The contracts, demonic pacts, and tattoo symbolism 00:18:08 Breaking down the greenhouse heist 00:20:28 CGI highs and lows in action scenes 00:21:55 Mephisto's growing control over Parker 00:23:06 Predictions for Mephisto, Doctor Doom, and future MCU tie-ins 00:25:01 Comic history of Mephisto, Ghost Rider, and potential Phase 7 arcs 00:26:46 Mid-season rating and final thoughts 00:29:10 Armor Wars, Disney's past mistakes, and the show's chopped-up structure 00:30:36 What's working and what we hope to see next Key Takeaways: Ironheart starts slow but picks up steam by episode 3, with tighter dialogue and higher stakes. Dominique Thorne (Riri) and Anthony Ramos (Parker/The Hood) deliver strong, grounded performances. The show leans heavily on Wakanda Forever as backstory—watching it first is essential. Parker's contracts and tattoos hint at Mephisto's presence, possibly laying groundwork for Midnight Sons or Doctor Doom. Chicago is a refreshing setting, adding a fresh visual layer rarely seen in Marvel properties. Disney's batch-release of episodes may reflect leftover strategy from the Chapek-era content slate. Natalie's role as an AI based on Riri's memories is an emotional standout. The Hood may become a recurring villain across MCU titles like Daredevil: Born Again. Memorable Quotes: “You don't hear heroes say that very often—but sometimes, you're not okay.” “Ramos never misses. He's the most compelling thing on screen right now.” “These characters feel like NPCs. The only ones that feel real are Riri and The Hood.” “This should've been a movie. You can feel how it was chopped up.” “That's not ink—it's a contract spreading across his skin.” Call to Action: Enjoying the episode? Support Challenge Accepted by subscribing, rating us five stars, and sharing with a Marvel-loving friend. Join the conversation using #ChallengeAcceptedPodcast on social media. Links and Resources: Visit GeekFreaksPodcast.com for all our news, reviews, and episodes. It's our official hub for everything geek culture. Follow Us Online: Instagram: @ChallengeAcceptedLive TikTok: @ChallengeAcceptedLive Twitter: @CAPodcastLive Have a Challenge for Us? Got a show, movie, or comic you'd like us to tackle? Email your ideas or questions to ChallengeAcceptedGFX@gmail.com or DM us on socials. Apple Podcast Tags: Ironheart, Marvel, MCU, Disney Plus, Riri Williams, Anthony Ramos, The Hood, Mephisto, Marvel Phase 5, Marvel Reviews, Comic Book TV, Midnight Sons, Marvel Villains, Chicago Superheroes, Armor Wars, Ghost Rider, Dominique Thorne, Challenge Accepted Podcast

Der FC Bayern hat den Gruppensieg bei der Klub-WM gegen Benfica verspielt und muss nun gegen Flamengo ran. Woran es in der Hitze von Charlotte scheiterte und was Bayern in der nächsten Runde erwartet, erklärt kicker-Reporter Georg Holzner. Außerdem: Wirtz weg, Frimpong weg, Tah weg - wie geht es in Leverkusen weiter?

Trump announced a ceasefire, claiming that Israel and Iran both approached him asking for peace. Plus, IDF says Iran launched missiles towards Israel as ceasefire nears. And, FBI and DHS warn of heightened threat environment in U.S. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Episode Summary Join Dr. Eric Balcavage and Dr. Kelly Halderman for this milestone 200th episode of Thyroid Answers! This comprehensive discussion covers the evolution of thyroid care, key lessons learned from treating hundreds of patients, and the future of thyroid recovery. Dr. Eric shares his 70% patient recovery rate and explains why the shift from management to recovery is revolutionizing thyroid care. Key Topics & Timestamps

Jackson Moody has been the Foundation Phase Lead Coach at Aston Villa for 8 years. Jackson discusses his role at one of the biggest clubs and most successful academies in the country.

The future of AI isn't coming; it's already here. With NVIDIA's recent announcement of forthcoming 600kW+ racks, alongside the skyrocketing power costs of inference-based AI workloads, now's the time to assess whether your data center is equipped to meet these demands. Fortunately, two-phase direct-to-chip liquid cooling is prepared to empower today's AI boom—and accommodate the next few generations of high-powered CPUs and GPUs. Join Accelsius CEO Josh Claman and CTO Dr. Richard Bonner as they walk through the ways in which their NeuCool™ 2P D2C technology can safely and sustainably cool your data center. During the webinar, Accelsius leadership will illustrate how NeuCool can reduce energy savings by up to 50% vs. traditional air cooling, drastically slash operational overhead vs. single-phase direct-to-chip, and protect your critical infrastructure from any leak-related risks. While other popular liquid cooling methods carry require constant oversight or designer fluids to maintain peak performance, two-phase direct-to-chip technologies require less maintenance and lower flow rates to achieve better results. Beyond a thorough overview of NeuCool, viewers will take away these critical insights: The deployment of Accelsius' Co-Innovation Labs—global hubs enabling data center leaders to witness NeuCool's thermal performance capabilities in real-world settings Our recent testing at 4500W of heat capture—the industry record for direct-to-chip liquid cooling How Accelsius has prioritized resilience and stability in the midst of global supply chain uncertainty Our upcoming launch of a multi-rack solution able to cool 250kW across up to four racks Be sure to join us to discover how two-phase direct-to-chip cooling is enabling the next era of AI.

It wasn't a phase, mom will go over the life and crimes of teens and young adultsIn this episode of Murder Bucket, part of the It Wasn't a Phase, Mom series, we dive deep into the harrowing case of the Richardson Family Murders. What started as a seemingly normal family life took a dark and devastating turn that shocked the community. Join us as we explore the events leading up to the tragedy, the chilling details of the crime, and the aftermath that left an indelible mark. Prepare for a gripping true crime story that reminds us just how fragile life can be.Follow us on all social media!Facebook - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/bucketmurd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/TheMurderBucket⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/murdbucket/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok -⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@murderbucketpod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://murderbucketpod.wordpress.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

„Jetzt beginnt Phase zwei der Zeitenwende“, sagte gerade der deutsche Außenminister in einem Interview mit dem Spiegel. Wenn aktuell die zweite Phase einer Politik der Kriegstreiberei anläuft, wie sieht dann die dritte Phase aus? Der offene Weltkrieg? Die „Zeitenwende“ ist eines der schlimmsten Propagandastücke, das die Mächtigen je auf der Bühne der Republik aufgeführtWeiterlesen

Finishing up a cycle of relief and refreshment

Send us a textMany direct-to-consumer brands get stuck in the early stages of growth. This video breaks down the four phases every brand faces, from founder-led growth to omnichannel expansion. Understand what holds back revenue at $50K, $250K, and beyond.Ready to grow faster on Amazon? Book a call and let the experts take over: https://bit.ly/4jMZtxu#DirectToConsumer #EcommerceGrowth #BrandScaling #StartupTips #amazonDTCTimestamps:00:00 - Why Direct-to-Consumer Brands Struggle00:27 - Phase 1: Founder Growth Explained01:23 - Phase 2: The Paid Media Trap02:55 - Phase 3: Lifetime Value and Conversion Rate Focus04:46 - Phase 4: Omnichannel Expansion06:13 - Secret Phase 5: Becoming a Household Name06:51 - When Should You Hand Over the Reigns?----------------------------------------------Follow us:LinkedIn: https://www.linkedin.com/company/28605816/Instagram: https://www.instagram.com/stevenpopemag/Pinterest: https://www.pinterest.com/myamazonguys/Twitter: https://twitter.com/myamazonguySubscribe to the My Amazon Guy podcast: https://podcast.myamazonguy.comApple Podcast: https://podcasts.apple.com/us/podcast/my-amazon-guy/id1501974229Spotify: https://open.spotify.com/show/4A5ASHGGfr6s4wWNQIqyVwSupport the show

In this live episode from the LSI conference in California, Etienne Nichols is joined by Ashkon Rasooli to break down what it really takes to build a high-performing quality management system (QMS) in medtech—from startup chaos to post-market scale. Ashkon shares a phased approach to aligning QMS implementation with product development, explains the concept of "enforcement points," and reveals how founders can reduce the burden of compliance by starting small and planning ahead. If you're navigating regulatory requirements while trying to stay innovative, this episode is your roadmap to smarter, leaner quality.Key Timestamps00:02 – Introduction to Greenlight Guru and medtech process integration01:15 – QMS evolution from startup to commercialization03:00 – Phase-based product development overview (Phases 0–6)06:35 – Why QMS should follow product needs, not just regulatory triggers09:10 – Agile vs. proceduralism in quality systems11:50 – Building a quality culture during the feasibility phase15:25 – When to implement QMS controls and how to prepare for “enforcement points”18:40 – Investor-driven and regulatory QMS triggers21:10 – How early QMS planning saves time and reduces future remediation26:20 – Ashkon's final advice for startups: start small and stay proactiveStandout Quotes"You've got to take the BS—being burdensome—out of QMS."Ashkon Rasooli redefines QMS as a project management tool, challenging the notion that compliance must be a burden. This quote encapsulates his philosophy of proactive, phased implementation that actually enhances product development."Start small and do a little bit at a time—it won't seem like a burden."A practical mantra for startups, this advice underscores how a gradual, well-aligned QMS rollout can prevent last-minute fire drills and wasted effort.Top TakeawaysUse the "Phase 0–6" Model to Guide QMS Rollout – Align QMS implementation with the stages of product development to ensure each step supports the next.Don't Wait for Enforcement Points – Start building your QMS before regulators or investors demand it to avoid remediation-heavy implementations.Prioritize Culture Before Controls – In early feasibility, focus on aligning your team with medtech's safety responsibilities, rather than formal procedures.Procedures Should Support Outcomes, Not Just Check Boxes – Avoid proceduralism by tying every process back to its intended quality objective.Regulatory Strategy = Investor Strategy – QMS maturity is increasingly scrutinized during due diligence. Treat it as a value driver, not just a cost.ReferencesAshkon Rasooli on LinkedInGreenlight Guru – Quality management software for medical devicesEtienne Nichols on LinkedIn – Connect with the hostISO 13485 vs. ISO 9001 – Explains how medical device quality systems build on general standardsISO 14155 Overview – Relevant for clinical validation proceduresMedTech 101: What Are “Enforcement Points”?In the context of QMS, enforcement points are moments when external stakeholders (regulators or investors) require proof of formalized processes. Think of it like a driver's license checkpoint—you may be cruising just fine, but at that moment, you must prove you're compliant. The earlier you prep for them, the smoother your...

Michael Fanning is a real estate coach specializing in mindset transformation and helping real estate professionals scale their businesses through strategic systems and delegation. Michael teaches "The Windmere Way" class and provides coaching to help agents transition from working harder to working smarter.This transformative episode dives deep into identifying High Income Producing Activities (HIPAs) and mastering the art of strategic delegation for real estate professionals. Michael explores the critical mindset shift from "I have to do everything" to "I choose to do what only I can do."[00:00 - 02:30] Introduction & Core ConceptWelcome and episode overviewThe mindset shift: Working smarter, not harderIntroduction to High Income Producing Activities (HIPAs)[02:30 - 08:00] Defining High Income Producing ActivitiesWhat activities actually generate revenue in real estateLead generation activities (prospecting, networking, sphere of influence)Client-facing activities (consultations, negotiations, showings)Business development and strategic partnershipsWhat's NOT on the HIPA list (administrative tasks, graphic design, etc.)[08:00 - 18:00] The Four-Phase Delegation Process ModelPhase 1: The Doer (0-10 transactions/year)Phase 2: The Strategic Delegator (10-25 transactions/year)Phase 3: The Team Builder (25-50 transactions/year)Phase 4: The Business Owner (50+ transactions/year)[18:00 - 25:00] Practical Implementation StrategyStep 1: Time audit exerciseStep 2: Calculate your target hourly rateStep 3: Start small and strategicStep 4: Create systems firstStep 5: Measure and adjust[25:00 - 32:00] Finding and Hiring Your First AssistantTypes of administrative help (Virtual assistants, local assistants, specialized services)Where to find qualified candidatesWhat to look for in candidatesProven hiring process and tips[32:00 - 37:00] Overcoming Delegation ResistanceCommon objections and mindset barriers"Nobody can do it as well as I can"Cost concerns and opportunity cost analysisFear of losing controlTime investment in training[37:00 - 40:00] Recommended Reading & ClosingBook recommendations for continued growthFinal thoughts on working smarterCall to action and contact informationTarget Goal: Spend 70% of your time on high income producing activitiesDelegation Rule: If someone else can do it for less than your target hourly rate, delegate itStart Small: Begin with one delegation decision and build from thereSystems First: Create clear processes before delegatingMindset Shift: Move from operator to orchestratorEssential Books Mentioned:Deep Work by Cal NewportThe E-Myth Revisited by Michael GerberTraction by Gino WickmanAtomic Habits by James ClearWho Not How by Dan SullivanThe Four Hour Work Week by Tim FerrissGood to Great by Jim CollinsThe Hard Thing About Hard Things by Ben HorowitzCRM Systems: Chime, CloseVirtual Assistant Platforms: Belay, Time Etc, OnlineJobs.phReal Estate VA Services: MyOutDesk, VirDeskProject Management: AsanaCommunication: SlackTraining Tool: Loom (for creating SOPs with screen recording)Job Boards: ZipRecruiter, Upwork, LinkedInReady to take your real estate business to the next level?Coaching Services AvailableWebsite: windmercoaching.comLearn about "The Windmere Way" classIndividual coaching for mindset and goal achievementComplete a one-week time audit of your activitiesCalculate your target hourly rateIdentify one task to delegate this weekChoose one recommended book to read this monthBe awesome and help somebody!If this episode helped you think differently about delegation and working smarter, please rate and review. Share with an agent who needs to hear this message - sometimes the person who needs it most is just one share away.Episode OverviewShow Segments & TimestampsKey TakeawaysRecommended Reading ListTools & Resources MentionedContact InformationEpisode Challenge

The trial of Jesus is really a trial of all those around him. Peter hits rock bottom as he denies Jesus three times, and Annas fails to grasp his own need for Jesus. Peter's story is our story: repeated failing, yet restored by the faithfulness of Christ. His story reminds us that Jesus can bring us back from the brink if only we would turn to Him. Our God is high and lifted up, but He also has compassion on those who have hit rock bottom: “For thus says the One who is high and lifted up, who inhabits eternity, whose name is Holy: ‘I dwell in the high and holy place, and also with him who is of a contrite and lowly spirit, to revive the spirit of the lowly, and to revive the heart of the contrite.” (Isaiah 57:15) Take-Home Message: Christ's faithfulness triumphs over my failures.  Christ's faithfulness triumphs over… My failure to see reality (12-14). The Trial of Jesus Phase 1 of Jewish trial: Jesus before Annas (Jn. 18:12-14, 19-23). Phase 2 of Jewish trial: Jesus before the Sanhedrin (Matt. 26:57-68). Phase 1 of Roman trial: Jesus before Pilate (Jn. 18:28-38a; Matt. 27:11-14). Phase 2 of Roman trial: Jesus before Herod Antipas (Lk. 23:6-12). Phase 3 of Roman trial: Jesus before Pilate again (Jn. 18:38b-19:16; Matt. 27:15-31). My failure to follow boldly (15-18). Why did Peter deny Jesus?Wrong expectation Wrong confidence Wrong urgency My failure to recognize authority (19-24). My failure to stop failing (25-27). Message: The Trial and Denial of Jesus Scripture: John 18:12-27 Simple. Authentic. Jesus. Prairiebible.org

FBI Releases Secret Docs Exposing Mass Voter Fraud, Article by John Zmirak. Trump- Don't Let the Rioters Win and Gold Has Entered 3rd & FINAL Phase: Why $10,000 oz Could Be Coming.   FBI Releases Secret Docs Exposing Mass Voter Fraud John Zmirak. Trump Learned the Bitter Lesson of 2020: Don't Let the Rioters Win Gold Has Entered 3rd & FINAL Phase: Why $10,000 oz Could Be Coming   FBI Releases Secret Docs Exposing Mass Voter Fraud to Rig 2020 Election Against Trump! FAKE Ballots Watch this video at- https://youtu.be/SfK7CHs9ABw?si=39TbBb7dcAc39zo4 Benny Johnson 4.77M subscribers 158,699 views Jun 17, 2025 This story is INSANE! BECOME A MEMBER:    / @bennyjohnson   FOLLOW OUR NEW CHANNELS: Benny On The Block:    / @bennyontheblock   Benny's Brews:    / @bennysbrews   FOLLOW BENNY ON SOCIALS: https://www.bennyjohnson.com/follow CHECK OUT OUR MERCH: https://shop.bennyjohnson.com/ Sign up for The Benny Newsletter: https://www.bennyjohnson.com/newsletter SUBSCRIBE TO THE PODCAST https://www.bennyjohnson.com/thebenny...   Gold Has Entered 3rd & FINAL Phase: Why $10,000 oz Could Be Coming | Mike Maloney Join Mike Maloney, best-selling author and seasoned gold investor, as he unveils the third and final stage of gold's monumental bull market. In this eye-opening presentation, Mike draws compelling parallels between today's gold surge and the infamous 1970s gold rush — when prices soared 25x in just months. Discover why gold and silver are “Giffen goods” — assets that gain demand as prices rise — and how global fear, greed, and economic instability could ignite the Great Gold & Silver Rush of the 21st Century. Backed by 20+ years of research, historic data, and insider insights, this video reveals: Why institutional and media attention signals a coming stampede How modern markets are primed for a price explosion Why gold could surpass $3,000... $5,000... even $10,000 per ounce If you think gold's best days are behind it, think again. Watch this video at- https://youtu.be/dxr_9zdGmZA?si=E_kn2PyAHqR7-E04 GoldSilver 824K subscribers 58,592 views Jun 17, 2025 Get Mike Maloney's 1st book for free here: http://www.GoldSilver.com/freebook ----------------------------------------------------------------- GoldSilver is one of the most trusted names in precious metals. Since 2005, we've provided investors with both education and world-class bullion dealer services. We offer a wide selection of bullion products, private vault storage, global shipping, and easy payment choices. Buy Precious Metals at: https://www.goldsilver.com Get Free content from Mike's new book here: http://www.ggsr21.com Subscribe to our channel: https://www.youtube.com/c/goldsilver?... Get Essential Gold & Silver News—Delivered Twice a Week: https://goldsilver.com/join-our-newsl... Follow Mike on Twitter:   / goldsilver_com   Follow us on Facebook:   / goldsilverdotcom   Check out our sister channel Wealthion @Wealthion featuring regular guests such as Jim Rickards, Rick Rule, Stephanie Pomboy, Lance Roberts, John Hathaway, Alisdair McLeod, Simon Hunt, John Rubino, Jim Rogers, Marc Faber and more. As always, thank you for your support. M.   Article by John Zmirak: John Zmirak. Trump Learned the Bitter Lesson of 2020: Don't Let the Rioters Win Find the article at- https://stream.org/trump-learned-the-bitter-lesson-of-2020-dont-let-the-rioters-win/   Trump Learned the Bitter Lesson of 2020: Don't Let the Rioters Win By John Zmirak Published on June 12, 2025 As gangs of illegal aliens and radical activists attack ICE officers and now local police in the streets of Los Angeles, I'm reminded of the race riots of 2020, and the mistakes most of us made while they were happening. In case you've blotted those ugly memories from your mind, let's review what happened in the aftermath of the botched arrest of career criminal George Floyd:   The police officers involved were immediately pulled from duty, then quickly arrested and charged. The System was working. There was literally nothing to riot about, except the vague and tendentious claim that “systemic racism” was killing black Americans. The Marxist group Black Lives Matter used Floyd's accidental death as a bloody shirt to wave around, demanding (and getting) hundreds of millions of dollars from large corporations to spend however it wished (for instance, on fancy homes and salaries). Conservative pundits and churches adopted that organization's mantra and offered uncritical support — desperate to establish their “antiracist” bona fides and protect their reputations. A series of coordinated “protests” erupted across the country, demanding that governments defund the police. Over and over, these protests turned violent, devolving into riots that saw the looting of neighborhoods poor and rich alike. Our media gaslit us with reports that these events were “mostly peaceful,” even as fires lit by arsonists raged on camera in the background. In blue states like Minnesota and California, Democrat governors who were savagely enforcing COVID lockdowns allowed the rioters to run free — pulling police from the scene and refusing to use their National Guards to protect citizens and their property. This was the starkest example of anarcho-tyranny in U.S. history … until the January 6 fedsurrection, that is. People who sneered when black entrepreneur and former presidential candidate Herman Cain died of COVID after attending a Trump campaign event and insisted that in-person voting was too dangerous to be allowed defended the riots publicly from the charge that they were “superspreader events.” Their excuse? “Racism is a threat to public health.” Trump did not federalize the National Guard in those rogue states to impose law and order. Like many of his supporters, and likely the advisors who convinced him to remain inert, I reasoned, “Let the blue cities burn. We'll make sure the federal government doesn't pay to rebuild them. The Left is trying to trap Trump into overreacting by using force in the hope that civilians will suffer and he will look like the dictator they've been calling him since Election Night 2016.” I now realize Step 6 was a huge mistake, as I'm sure Trump and his team had the chance to reflect on during the four years of lawfare and chaos they all endured under The Secret Committee Formerly Known As Joe Biden.   Now, we need to analyze why this is true so we can give full-throated support to restoring the rule of law today.   Abandoning Territory to Marxist Gangs Is Wrong Donald Trump is president of the entire United States, and he works for every American. That includes law-abiding citizens in blue states and cities who might not support mayors and governors committed to flouting U.S. laws on immigration, citizenship, and public order. Trump represents the harried, hunted police who work in Los Angeles and the taxpayers forced to fund the health care, education, and even transgender treatments of millions of illegal aliens the Biden regime let in.   We're supposed to love our neighbor. At minimum that includes our fellow Americans — even those deluded enough to believe that we owe citizenship and welfare payments to foreigners who broke into our national home. Just as we shouldn't hand out free heroin to addicts and shrug at the thought that they might OD, we shouldn't hand anarchy to Californians and Minnesotans, even if it's what they say they want. “Stinks to be you” isn't a New Testament maxim.   When Moderation Looks Like Weakness, It Is Weakness Letting blue cities burn or sink in their own squalor sounds tempting. However, it's not just a crime: it's a blunder, as political philosopher Yoram Hazony points out.   The spectacle of U.S. cities roiling with chaos, falling into the hands of Leftist mobs waving foreign flags, makes America look weak and vulnerable in the eyes of its foreign enemies. Furthermore, it makes any president who presides over it seem like a wounded, crippled giant. That was true in 2020, and it's even truer today — when the riots are aimed not at some nebulous, made-up bogeyman like “systemic racism” or “whiteness,” but directly at the law enforcement policies that got Trump elected and are, rightly, very popular: mass repatriation of blatantly illegal aliens.   These riots are aimed at Trump as a leader and his voters as citizens. They are armed, organized efforts to deprive the U.S. government of its legitimate monopoly on violence in large swathes of its territory. If Trump isn't willing to take every legal, constitutional measure to crush them and punish the perpetrators, he might as well resign right now and flee with his family into exile like the former Shah of Iran. Of course, that would leave all of us under a revolutionary tyranny every bit as ugly as Iran's.   Mobs Follow the Strong and Scorn the Weak It's a sad fact of fallen human nature: A high percentage of people don't join causes or adopt opinions because of rational argumentation, or even moral sentiments. People flock to the strong and steadfast, and naturally feel contempt for those who lack the courage of their convictions.   One of the main reasons that George Washington became first a national hero, then our leader in the fight for independence, was his obvious personal fearlessness. Bullets whizzed past him, shot through his hat and even his coat, and he was unperturbed. By contrast, the rival General Horatio Gates who sought to replace Washington at the head of the Continental Army disgraced himself by fleeing a 1780 military defeat at Camden, S.C., leaving his beaten troops behind. Trump can't afford to do the same today.   Please Support The Stream: Equipping Christians to Think Clearly About the Political, Economic, and Moral Issues of Our Day. Even thugs who stand for evil ideas can gather a following for their bravery. In their case, it's the gumption of bullies, and attracts other would-be bullies. But that's how warlords have triumphed all too often for millennia.   The thugs of illegal alien mobs, backed by the bullies in power in cities like Los Angeles, are counting on decent people to hide in their homes and on Trump to hide in the White House. We cannot let these lawless, unpatriotic, un-American mobs raise foreign flags over our cities. There's a word for that: It's “surrender.”   We didn't vote for a white flag, but for the man who stood tall while bleeding and shouted, “Fight, fight, fight!” -----------------------------------------------------------------------     John Zmirak is a senior editor at The Stream and author or coauthor of 14 books, including The Politically Incorrect Guide to Immigration and The Politically Incorrect Guide to Catholicism. His newest book is No Second Amendment, No First.   --------------------------------------------------------------------  Check out our ACU Patreon page: https://www.patreon.com/ACUPodcast   HELP ACU SPREAD THE WORD!  Please go to Apple Podcasts and give ACU a 5 star rating. Apple canceled us and now we are clawing our way back to the top. Don't let the Leftist win. Do it now! Thanks. Also Rate us on any platform you follow us on. It helps a lot. Forward this show to friends. 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We are designed to strategically impact the abortion industry through the following initiatives:… -------------------------------------------------------- Help CSI Stamp Out Slavery In Sudan Join us in our effort to free over 350 slaves. Listeners to the Eric Metaxas Show will remember our annual effort to free Christians who have been enslaved for simply acknowledging Jesus Christ as their Savior. As we celebrate the birth of Christ this Christmas, join us in giving new life to brothers and sisters in Sudan who have enslaved as a result of their faith. https://csi-usa.org/metaxas   https://csi-usa.org/slavery/   Typical Aid for the Enslaved A ration of sorghum, a local nutrient-rich staple food A dairy goat A “Sack of Hope,” a survival kit containing essential items such as tarp for shelter, a cooking pan, a water canister, a mosquito net, a blanket, a handheld sickle, and fishing hooks. Release celebrations include prayer and gathering for a meal, and medical care for those in need. The CSI team provides comfort, encouragement, and a shoulder to lean on while they tell their stories and begin their new lives. Thank you for your compassion  Giving the Gift of Freedom and Hope to the Enslaved South Sudanese -------------------------------------------------------- Food For the Poor https://foodforthepoor.org/ Help us serve the poorest of the poor Food For The Poor began in 1982 in Jamaica. Today, our interdenominational Christian ministry serves the poor in primarily 17 countries throughout the Caribbean and Latin America. Thanks to our faithful donors, we are able to provide food, housing, healthcare, education, fresh water, emergency relief, micro-enterprise solutions and much more. We are proud to have fed millions of people and provided more than 15.7 billion dollars in aid. Our faith inspires us to be an organization built on compassion, and motivated by love. Our mission is to bring relief to the poorest of the poor in the countries where we serve. We strive to reflect God's unconditional love. It's a sacrificial love that embraces all people regardless of race or religion. We believe that we can show His love by serving the “least of these” on this earth as Christ challenged us to do in Matthew 25. We pray that by God's grace, and with your support, we can continue to bring relief to the suffering and hope to the hopeless.   Report on Food For the Poor by Charity Navigator https://www.charitynavigator.org/ein/592174510   -------------------------------------------------------- Disclaimer from ACU. We try to bring to our students and alumni the World's best Conservative thinkers. All views expressed belong solely to the author and not necessarily to ACU. In all issues and relations, we hope to follow the admonitions of Jesus Christ. While striving to expose, warn and contend with evil, we extend the love of God to all of his children. ----------------------------------------------------------------------------------------- 

The Iranian regime is receiving an education of sorts this week, and while we await President Trump's decision on the extent of America's role in busting up the nuclear site at Fordow, the Free Press's Eli Lake (and host of the Breaking History podcast) returns to educate us on why surgical involvement in Iran fits with the "America First" agenda that voters signed up for last November.Plus, the reunited James, Charles, and Steve talk Skrmetti and Mamdani.- Music from this week's open: The Israeli Air Force has a hit on Iranian State Television

As most of you know, our Patreon audience has the INSIDE access to the KF Show. The year 2025 will be an important one for Patreon specifically and if you'd consider jumping up to the $5 level it would sure help. The $10 level will remain and we now have a brand new $20 level as well! All members who join at that level will receive a sticker swag pack in the mail, you'll be IMMEDIATELY entered in the monthly prize grab, and you'll receive a phone call from one (or all) of us to chat up whatever you want for 30 minutes! Thank you SO MUCH to those of you who have joined in for the extra content that is only for Patreon supporters. To get in on the action and support the show with a minor financial contribution just click the link below to sign up. Join up via Patreon at patreon.com/KFSHOW ======================================== Presented with Holley - Back for 2025!  Phase 3 of Kibbe and Friends is officially here, and Holley is back for more fun, foolishness, and flying orange Chargers! Once again we're proud to be associated with the historic name that has made cars fast for years and years, and their innovations continue forward (as always)! Make sure that you visit Holley.com to place your speed parts orders - and THANK THEM for continuing on as the Title Sponsor of the KF Show!  ======================================== Ron Francis Wiring Brings you the Celebrity Automotive Birthday! https://www.ronfrancis.com ======================================== Dallas Kibbe Racing Update! This episode featured the Dallas Kibbe Legends Car Racing Update segment! Dallas joined the show himself after his last race on June 13 at Hawkeye Downs in Cedar Rapids, IA. Long story short.....he won! It was his first win in a Legends car, ever!! To follow Dallas Kibbe Racing you can watch his stats and other racing information here. Check it out! https://www.facebook.com/DallasKibbeRacing https://www.instagram.com/dallaskibbe_13/ https://www.tiktok.com/@dallaskibbe_13 MyRacePass.com/drivers/178661.  ======================================== Dukes Review: S7E1 Happy Birthday General Lee The greatest race of the General Lee is not in this episode…..but it's the first win of the General, and I have recently been reminded that your first win is irreplaceable. There's no doubt about the fact that in the course of the Dukes of Hazzard, this is the race that put him on the map. Thomas Steven Wopat presents the birth of the General Lee and - whether he meant to or not - creates the canon of the entire series by answering what every little boy needed to know most. Why are the doors welded shut? It's here. What's under the hood of the General? It's here. Why is the General orange, with a rebel flag on the roof, a dixie horn under the hood, and why is it named General Lee? It's here. More importantly, how does an old dead wreck from a junkyard become able to fly leaps and bounds, win every race, catch every bad guy, win every girl for the Duke Boys, respond to it's name on command, be so much of a family member it gets it's own birthday cake, and become the most magical car in the history of the known universe and the most famous car in the world? It's here! Legit Episode Info Season 7, Episode 1 “Happy Birthday, General Lee” Written by Si Rose Directed by Tom Wopat 9/21/1984  ======================================== National Parts Depot Presents: Bernie on the News! https://www.npdlink.com. The post K&F Show #332: Hollywood Cars – Props Vs Copyrightable Characters; All Racing June Dukes Review: S7E1 “Happy Birthday General Lee” first appeared on The Muscle Car Place.

The Iranian regime is receiving an education of sorts this week, and while we await President Trump's decision on the extent of America's role in busting up the nuclear site at Fordow, the Free Press's Eli Lake (and host of the Breaking History podcast) returns to educate us on why surgical involvement in Iran fits […]

To watch Gerald Pollack's presentation from Confluence 2025, become a platinum member of https://www.TheWayFwrd.com. Platinum members also get access to live community calls, podcast guest Q&As, as well as our new platform helping you find like-minded community near you. Turn online alignment into an offline community — join us at TheWayFwrd.com to connect with like-minded people near you. It's the best way to support this podcast and the movement we're building together: https://thewayfwrd.com/join/ Alec is joined by Dr. Gerald Pollack, professor at the University of Washington, to explore the “fourth phase” of water and its vital role in biological energy. They discuss how structured water near cell surfaces, called the Exclusion Zone, challenges traditional biology, the energy sources behind it, and its implications for cell health and cancer. Dr. Pollack also reflects on the scientific pioneers who first proposed these ideas and the resistance faced by revolutionary research. For more details, links, and resources mentioned in this episode, visit our website: https://thewayfwrd.com/   Resources and Links Pollack Lab Website – https://www.pollacklab.org/   The Way Forward podcast is sponsored by: New Biology Clinic: Experience individually tailored terrain-based health services with virtual consults, practitioner livestreams, movement classes, and more. The New Biology Clinic's motivation is to make you healthy and keep you that way. Visit https://NewBiologyClinic.com and enter code TheWayForward for $50 off your activation fee. Members of The Way Forward get the full activation fee waived. Become a member of The Way Forward here: https://thewayfwrd.com/membership-sign-up/ ————————— RMDY Collective: Dedicated to making homeopathy accessible with high-quality remedies and hands-on training. Discover how this holistic approach supports natural healing and empowers you to take charge of your wellness.  Explore more at RMDY Collective at https://rmdycollective.org/?bg_ref=MKho6KZowa Enroll in RMDY Academy at https://rmdyacademy.org/?bg_ref=MKho6KZowa ————————— Medicamentum Authentica: Boost energy, mental clarity, and vitality with Authentica Shilajit™, a mineral-rich supplement trusted for holistic wellness. It supports stamina, focus, hormonal balance, and detoxification while promoting long-term health. Get 10% off with code WAYFORWARD at https://medauthentica.com/wayforward

In this episode, I'm diving into the hot topic of 48-hour fasting during your follicular phase. I talk about the real science-backed benefits that fasting does provide & my recommendations for whether or not I think it could be beneficial for your fertility! Chapters in this episode: 00:00 Exploring the Benefits of Fasting03:00 Who Should Avoid Fasting?05:50 Alternatives to Fasting for Fertility09:07 Cleansing vs. Fasting: What's Best?11:54 Practical Fasting Tips for Hormonal Health14:46 Creating a Sustainable Lifestyle for FertilityWays to work with Corinne: Join the Mind Your Hormones Method, HERE! (Use code PODCAST for 10% off!!)Join the Mind Your Hormones Community to connect more with me & other members of this community!Come hang out with me on Instagram: @corinneangealicaOr on TikTok: @corinneangelicaEmail Fam: Click here to get weekly emails from meMind Your Hormones Instagram: @mindyourhormones.podcast Disclaimer: always consult your doctor before taking any supplementation. This podcast is intended for educational purposes only, not to diagnose or treat any conditions. 

It's ... Indicators of the Week! Our weekly look at some of the most fascinating economic numbers from the news. On today's episode: the monetary cost of Trump's military parade, looks like FEMA could be phased out, and another change to Warner Bros. Discovery.Related episodes: Coyote vs. Warner Bros. Discovery (Apple / Spotify) Gilded Age 2.0? (Apple / Spotify)For sponsor-free episodes of The Indicator from Planet Money, subscribe to Planet Money+ via Apple Podcasts or at plus.npr.org.Fact-checking by Sierra Juarez. Music by Drop Electric. Find us: TikTok, Instagram, Facebook, Newsletter. Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy