Podcasts about fisetin

Doctor's Farmacy with Mark Hyman, MD: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

BUFFALO, NY — May 6, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 2, 2025, titled “Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition.” In this study, researchers at Johannes Kepler University Linz found that fisetin, a natural substance found in fruits and vegetables, helps protect blood vessels from hardening, which is a common problem in older adults and people with kidney disease. This discovery highlights fisetin's potential to prevent vascular calcification and reduce cardiovascular damage caused by aging and chronic kidney disease. The research, led by first author Mehdi Razazian and corresponding author Ioana Alesutan, focused on vascular calcification—a condition in which blood vessels stiffen due to calcium deposits. This process is common in aging and chronic kidney disease and increases the risk of heart attacks and strokes. Using human and mouse study models, the researchers tested fisetin's ability to prevent this calcification in vascular smooth muscle cells (VSMC), which play a key role in maintaining vessel health. Fisetin, known for its anti-inflammatory and antioxidant properties, significantly reduced calcium buildup and calcification markers under stress conditions that mimic disease. The team also discovered that fisetin suppresses activity in a signaling pathway called p38 MAPK, which is known to promote calcification. This effect depends on a protein called DUSP1. When DUSP1 was blocked, fisetin could no longer protect the cells, showing that this protein is essential for its anti-calcification activity. The researchers confirmed fisetin's protective effects in isolated mouse arteries and in living mice treated with high doses of vitamin D, which typically increases arterial calcification. “Mechanistically, fisetin requires the phosphatase DUSP1 to inhibit p38 MAPK in order to mediate its protective effect on VSMC calcification.” Importantly, the researchers tested fisetin under conditions similar to human disease. When VSMCs were exposed to blood serum from kidney dialysis patients—a condition known to trigger vascular calcification—fisetin again reduced calcium buildup and protected the cells. These findings suggest fisetin could be useful in countering the harmful vascular effects seen in chronic kidney disease. This study adds to growing evidence that fisetin may protect blood vessels from aging-related damage. While more research is needed before it can be used in clinical treatments, the study highlights fisetin as a promising candidate for slowing or preventing vascular calcification. The findings could have broad implications for aging populations and individuals with kidney disease, who are at greater risk for heart problems due to vascular stiffening. Read the full paper: DOI: https://doi.org/10.18632/aging.206233 Corresponding author: Ioana Alesutan – ioana.alesutan@jku.at Keywords: aging, vascular calcification, vascular smooth muscle cells, fisetin, dual-specificity phosphatase 1, p38 MAPK ______ To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world's largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

Dr. Ronald Hoffman and Nutritionist Leyla Muedin continue their reveal of the supplements they personally take.

In this special New Year's edition Q&A Dr. Ronald Hoffman and Nutritionist Leyla Muedin share their personal supplement regimens for 2025. They discuss the variety of supplements they take, including multivitamins, specific minerals, omega-3s, anti-inflammatories, probiotics, and immune-supportive nutrients. They also emphasize the importance of personalized nutrition and caution listeners against directly mirroring their supplement routines. The episode includes advice on seasonal adjustments to supplementation, the benefits of different nutrient combinations, and general tips for maintaining a balanced approach to supplement intake. Dr. Hoffman and Leyla also touch on their personal health goals and the rationale behind their choices, offering listeners insights into optimizing their own supplement strategies.

In this episode of the Vibe Science podcast, hosts Ryan Alford and Chris Hansen delve into the science of health optimization and longevity with Dr. Vanessa Pavy, a naturopathic doctor from Life Extension. Together, they explore the transformative potential of supplements, highlighting key compounds like fisetin and paraquinone (PK). Dr. Peavy sheds light on fisetin's role in clearing senescent cells and PK's impact on enhancing mitochondrial function. The discussion emphasizes the value of personalized health strategies, the importance of routine blood work, and the vital roles of nutrients like CoQ10 and lipoic acid in supporting energy production and overall wellness.TAKEAWAYSTheme of longevity and health optimizationImportance of personalized health managementDiscussion of various supplements and their benefitsIntroduction and explanation of fisetin as a senolytic compoundRole of senescent cells in aging and healthImportance of telomeres in cellular healthMonitoring health through regular blood work and biomarkersEmerging supplements like ergothioneine and their benefitsImpact of mitochondrial health on overall well-beingRelationship between aging and the decline of CoQ10 production Follow us on Instagram: @Vibe.Science Subscribe to our YouTube Page: www.youtube.com/@Vibe.Science

In diesem Podcast spreche ich mit Prof. Dr. Clemens Schmitt, Professor für Hämatologie und Onkologie und leitender Forscher an der Charité Universitätsmedizin. Prof. Schmitt ist leitender Forscher am Max-Planck Delbrück-Zentrum für molekulare Medizin, dazu Direktor an der Uniklinik Linz und überhaupt international anerkannter Experte auch und besonders in Sachen zelluläre Seneszenz. Professor Clemens Schmidt erforscht mit seinem Team, wie und welche Senolytika beim Kampf gegen seneszente Zellen wirken könnten.   In dieser Folge behandeln wir unter anderem folgende Fragen: Was sind seneszente Zellen, und welche Rolle spielen sie im Alterungsprozess? Inwiefern sind seneszente Zellen verantwortlich für Alterskrankheiten wie Osteoarthritis, Fibrosen, Diabetes und neurodegenerative Erkrankungen wie Alzheimer? Wie beeinflusst der von seneszenten Zellen ausgeschüttete seneszenz-assoziierte sekretorische Phänotyp (SASP) den Alterungsprozess und die Entstehung von altersbedingten Entzündungen? Wie führt eine Chemotherapie bei jungen Menschen zu einer vermehrten Bildung von seneszenten Zellen, und welche langfristigen Auswirkungen hat dies auf das Altern? Was sind Senolytika, und wie wirken Substanzen wie Dasatinib, Quercetin und Fisetin bei der Eliminierung seneszenter Zellen? Welche ersten klinischen Erfolge wurden bei der Anwendung von Senolytika erzielt, und bei welchen Alterskrankheiten zeigen sie bereits Wirkung?   Weitere Informationen zu Prof. Schmitt findest du hier: https://www.bsio-cancerschool.de/bsio-faculty Du interessierst dich für Gesunde Langlebigkeit (Longevity) und möchtest ein Leben lang gesund und fit bleiben, dann folge mir auch auf den sozialen Kanälen bei Instagram, TikTok, Facebook oder Youtube. https://www.instagram.com/nina.ruge.official https://www.tiktok.com/@nina.ruge.official https://www.facebook.com/NinaRugeOffiziell https://www.youtube.com/channel/UCOe2d1hLARB60z2hg039l9g   Disclaimer: Ich bin keine Ärztin und meine Inhalte ersetzen keine medizinische Beratung. Bei gesundheitlichen Fragen wende dich bitte an deinen Arzt/deine Ärztin.   STY-127

Do you want to slow down the aging process and boost your health? In this episode. Chalene Johnson shares the seven most powerful anti-aging supplements that can be found over-the-counter. Discover how supplements like Creatine, Spermidine, Resveratrol, Fisetin, Collagen, NMN and Magnesium can help improve energy, reduce inflammation, support muscle health, enhance cognitive function, and promote overall longevity. Drawing from recent insights shared by her longevity doctors, she breaks down everything you need to know to age gracefully and feel your best. Plus, Chalene shares tips on boosting autophagy, supporting brain function, and maintaining optimal energy levels. Aging gracefully doesn't mean slowing down—unlock the benefits of these scientifically-backed solutions and embrace the best strategies for staying youthful. Watch An All New YouTube Video this Sunday!  

Kannst du dir vorstellen, mit 85 Jahren noch voller Energie zu sein und deine besten Lebensjahre vor dir zu haben? In dieser neuen Folge der Flowgrade Show spreche ich mit Nicolas Ting über die faszinierende Welt der Langlebigkeit und mit welchen Stoffen unser Leben nicht nur verlängern, sondern auch verbessern können. Nicolas Ting ist ein leidenschaftlicher Ernährungswissenschaftler und Gesundheitscoach, der komplexe wissenschaftliche Konzepte in praktische und inspirierende Tipps verwandelt. Wir diskutieren die Definition von Langlebigkeit aus wissenschaftlicher und persönlicher Sicht, die Bedeutung von Verjüngung (Rejuvenation) und die Genauigkeit von Tests zum biologischen Alter. Nicolas erklärt mir seine Säulen eines gesunden Lebensstils und wie diese als die großen Hebel für die Langlebigkeit fungieren. Dazu sprechen wir über verschiedene Anti-Aging-Produkte und ihre Wirkungsweise, darunter NMN, den Booster und den Cell Primer von AVEA Life. Nicolas erklärt mir zum, Beispiel, warum NMN, eine Vorstufe von NAD+, besonders gut in Kombination mit Apigenin wirkt, wie die Kombination von Resveratrol und Ubiquinol die Energieproduktion in den Zellen verbessert und Senolytika wie Quercetin und Fisetin dabei helfen, alternde Zellen abzubauen. Viel Spaß mit dieser umfangreichen Folge rund um Longevity! Go for Flow. Für weitere Inhalte und Produkte für deine persönliche Transformation besuche uns hier: Flowgrade Webseite Für hochwertige Anti-Aging-Produkte, die deine Langlebigkeit und Gesundheit fördern, besuche AVEA Life und nutze den Code FLOWGRADE für 15% Rabatt. ►Wer ist Nicolas Ting? Nicolas Ting ist ein leidenschaftlicher Verfechter von Ernährung, gesundem Lebensstil und nachhaltigem Konsum. Mit über 10 Jahren Erfahrung in der Krankenpflege und einem Master in Ernährungs- und Lebensmittelwissenschaften an der Universität Bonn bringt er eine einzigartige Mischung aus medizinischem und wissenschaftlichem Hintergrund mit. Nach seiner Ausbildung entschied Nicolas sich, von der reaktiven Seite der Krankenpflege in die proaktive und präventive Gesundheitsförderung zu wechseln. Als selbstständiger Unternehmensberater für Ernährungs- und Gesundheitskommunikation sowie als Ernährungs- und Mentalcoach hat er zahlreiche europäische Firmen beraten und betreut. Nicolas liebt es, komplexe ernährungswissenschaftliche Zusammenhänge in eine leicht verständliche und authentische Sprache zu übertragen. Nicolas ist fest davon überzeugt, dass innovative und personalisierte Ernährung der Schlüssel zu Langlebigkeit und einem glücklichen, gesunden Älterwerden ist. In seiner Freizeit verbringt er gerne Zeit mit seiner Familie in der Natur, engagiert sich für nachhaltige Ernährung, betreibt ein kleines Hafergeschäft und bewirtschaftet mit Freunden einen Weinberg. Außerdem reist er gerne und ist Vater von zwei wundervollen Kindern. ► Investiere in deine Langlebigkeit mit AVEA Life! Für diejenigen, die ihre Langlebigkeit und Gesundheit aktiv verbessern möchten, empfehle ich die hochwertigen Produkte von AVEA Life. Diese innovativen Produkte basieren auf den neuesten wissenschaftlichen Erkenntnissen und sind darauf ausgelegt, die Zellalterung zu verlangsamen und das allgemeine Wohlbefinden zu steigern. Besuche AVEA Life und entdecke eine Auswahl an Anti-Aging-Produkten wie NMN, Booster und Cell Primer. Mit dem Code FLOWGRADE erhältst du 15% Rabatt auf deine Bestellung von Supplements und Wirkstoffen. Für den DNA-BioAge-Test, der dir einen detaillierten Einblick in dein biologisches Alter bietet, gibt es einen speziellen Rabattcode. Verwende den Code BIOAGE und erhalte 15% Rabatt auf den Test. Dieser Code ist nur bis zum 30. Juni 2024 gültig, also nutze die Gelegenheit und bestelle deinen Test separat! AVEA Life Supplements und Wirkstoffe: AVEA Life Produkte DNA-BioAge-Test: DNA-BioAge-Test Bestelle jetzt und beginne deine Reise zu einem längeren, gesünderen Leben! ► Kapitel 00:00 Die Frage nach der Langlebigkeit 03:15 Definition von Langlebigkeit 09:19 Epigenetische Tests und das biologische Alter 28:47 Das Toolkit für Langlebigkeit 57:23 Wirkstoffe für die Gesundheit 59:19 Erhöhung der Energie und Unterstützung des Zellabbaus 01:01:41 Senolytika: Quercetin und Fisetin 01:03:06 Zellrecycling und Mitochondrien-Gesundheit 01:05:01 Die Rolle von Spermidin bei der Entgiftung 01:05:57 Blutzuckerregulierung für gesundes Altern 01:12:24 Das Vitalitätsbündel: Ein Startpunkt für Langlebigkeit 01:19:56 Der Einfluss der Epigenetik auf zukünftige Generationen 01:26:39 Ernährung und Stressmanagement für Langlebigkeit Teile deine Gedanken zu dieser Episode und abonniere die Flowgrade Show für weitere spannende Einblicke und Interviews! ► Weiterführende Links• AVEA Life Website https://www.avea-life.com/flowgrade (15% Rabatt mit FLOWGRADE) • Nicolas' LinkedIn https://www.linkedin.com/in/nicolasting/ • Vitality Bundle https://avea-life.com/de/products/bundle• Flowgrade Produkte https://www.flowgrade.de/shop/ ► Kontakt: • YouTube Kanal abonnieren https://www.youtube.com/@flowgrade/?sub_confirmation=1 • Website https://www.flowgrade.de • Flowgrade Instagram https://www.instagram.com/flowgrade • FlowTribe Community https://flowtribe.community • Max Gotzler's Instagram https://www.instagram.com/max_gotzler • Facebook https://www.facebook.com/biotrakr • Twitter https://www.twitter.com/flowgrade • LinkedIn https://www.linkedin.com/company/biotrakr • Mail info@flowgrade.de #biohacking #podcast #langesleben

In dieser Episode unseres Podcasts „Beyond Lifespan“ erfährst du, wie bestimmte Moleküle aus Pflanzen deine Gesundheit und Lebensdauer beeinflussen können. Wir tauchen tief in die Welt der sekundären Pflanzenstoffe ein und entdecken die Vorteile von Resveratrol, Quercetin, Apigenin, Fisetin, Berberin und vielen mehr.

BUFFALO, NY- March 6, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions.” Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. In this new study, researchers Edwin Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner, Aaron Lin, Tavis L. Mendez, Hannah Went, Alan Tomusiak, Eric Verdin, Michael Corley, Lishomwa Ndhlovu, Ryan Smith, and Varun B. Dwaraka from the Institute For Hormonal Balance, TruDiagnostic, Buck Institute for Research on Aging, and Cornell University aimed to assess the effects of senolytic treatments on DNA methylation (DNAm), epigenetic age, and immune cell subsets. “[...] this study aims to comprehensively assess the impact of senolytic drugs on epigenetic aging through two longitudinal studies to address our research objective. The initial investigation focuses on a combination treatment of Dasatinib and Quercetin, while the subsequent phase incorporates Fisetin into the treatment regimen.” In a Phase I pilot study, 19 participants received Dasatinib and Quercetin (DQ) for 6 months, with DNAm measured at baseline, 3 months, and 6 months. Significant increases in epigenetic age acceleration were observed in first-generation epigenetic clocks and mitotic clocks at 3 and 6 months, along with a notable decrease in telomere length. However, no significant differences were observed in second and third-generation clocks. Building upon these findings, a subsequent investigation evaluated the combination of DQ with Fisetin (DQF), a well-known antioxidant and antiaging senolytic molecule. After one year, 19 participants (including 10 from the initial study) received DQF for 6 months, with DNAm assessed at baseline and 6 months. Remarkably, the addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of DQ on epigenetic aging. “Furthermore, our analyses unveiled notable differences in immune cell proportions between the DQ and DQF treatment groups, providing a biological basis for the divergent patterns observed in the evolution of epigenetic clocks. These findings warrant further research to validate and comprehensively understand the implications of these combined interventions.” DOI - https://doi.org/10.18632/aging.205581 Corresponding authors - Varun B. Dwaraka - varun@trudiagnostic.com Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Discord link: https://discord.gg/yHUhW2Wjc7 Research Papers: https://www.dryfastingclub.com/studies/ In this video, we delve into the nuanced practices and theories surrounding dry fasting, particularly focusing on the contrasting approaches of August Dunning and Filonov. Dunning, a prominent figure in the Western adaptation of dry fasting, presents a scientific and empathetic approach, differing from Filonov's traditional and rigorous methods. While acknowledging Filonov's significant contributions and experience, we lean towards Dunning's methodology which resonates more with modern, critical thinking and personal responsibility in health management. We explore the debate around Fisetin, a biohacker's gem, and discuss its alternatives like Quercetin and Curcumin, emphasizing the importance of a balanced, plant-rich diet and questioning the necessity of expensive supplements. The video also addresses the misconceptions about baking soda post-fasting and the potential risks of water absorption during dry fasting, highlighting the intriguing role of aquaporins in skin hydration. Join us as we dissect these complex practices, advocate for informed decision-making, and explore the science behind fasting and overall well-being. #DryFasting, #FastingScience, #HealthJourney, #Biohacking, #NutritionFacts, #WellnessTips Join us on Instagram https://instagram.com/dryfastingclub Join us on Twitter https://twitter.com/dryfastingclub The Dry Fasting Club does not provide medical advice. Always seek the advice of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition or treatment before undertaking a new healthcare regimen.

Episode 57: In this episode, host Angie Gust talks about senescent cells and fisetin.  When normal cells get too damaged (as in accumulating too much DNA damage), they could turn into cancer cells. To prevent this, these damaged cells change to where they cannot divide anymore, so in that way, they cannot become cancer cells. Rather, they became senescent cells.  A bad thing is that. these cells secrete substances that damage the healthy surrounding cells, contributing to aging.  Fisetin has been shown to be good at clearing out this senescent cells.  Now turning to the environment. The 2023 UN Climate Conference, COP28, concluded on December 13th. While some think it was an improvement over other conferences, others thought it did not go far enough and left loop holes. The deal calls for transitioning away from (not phasing out) fossil fuels  in energy systems, in a just, orderly and equitable manner ... so as to achieve net zero by 2050. There was an agreement to triple renewables and double energy efficiency by 2030. There is hope, but definitely more to be done.   References Carbon Brief. https://www.carbonbrief.org/cop28-key-outcomes-agreed-at-the-un-climate-talks-in-dubai/ Children of the Earth. https://www.childrenoftheearth.org/seigelman.htm IEA (2023), World Energy Outlook 2023, IEA, Paris https://www.iea.org/reports/world-energy-outlook-2023, License: CC BY 4.0 (report); CC BY NC SA 4.0 (Annex A) Life Extension. Feb 2021. Fisetin: A Senolytic That Extends Life.https://www.lifeextension.asia/magazine/post/fisetin-a-senolytic-that-extends-life Novos. https://novoslabs.co/causes-of-aging-senescent-cells/?gad_source=1&gclid=CjwKCAiAsIGrBhAAEiwAEzMlC_iEEf3Ylj76zw82sBSt2N5zk3OIqwLhsROkteGC5FQ5svuFTSkVVhoCBr8QAvD_BwE Novos. Why do we age? Cellular senescence. https://novoslabs.com/causes-of-aging-senescent-cells/ Pakalolo. Nov 16, 2023. httphttps://www.dailykos.com/stories/2023/11/16/2206148/-The-World-Meteorological-Society-Climate-heating-gases-reach-record-highs://www.dailykos.com/stories/2023/11/16/2206148/-The- Volcovici, V, Dickie, G, James, W. Dec 13, 2023. Nations strike deal at COP28 to transition away from fossil fuels. https://www.reuters.com/business/environment/countries-push-cop28-deal-fossil-fuels-talks-spill-into-overtime-2023-12-12/#:~:text=DUBAI%2C%20Dec%2013%20(Reuters),end%20of%20the%20oil%20age. World-Meteorological-Society-Climate-heating-gases-reach-record-high?pm_campaign=front_page&pm_source=trending&pm_medium=web Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28.    

Topfit mit 40. Geht das? Stell dir einfach mal vor, du bist in deinen 40ern oder 50ern und fühlst dich nicht nur fabelhaft, sondern bist auch in der Blüte deiner körperlichen und geistigen Fitness. Klingt wie ein Traum?  In der neuesten Episode der Flowgrade Show erfährst du, wie dieser Traum Wirklichkeit werden kann. Gemeinsam mit meinem Biohacker-Kollegen und guten Freund Andreas Breitfeld schaue ich mir die innovativsten Methoden des Biohacking zur Fitnessoptimierung ab 40 an. Warum das Ganze? Na ja, nächstes Jahr werde ich 40. Und da Andreas ein Jahrzehnt Vorspruch hat und so ziemlich alles ausprobiert hat, dachte ich, ich frage ihn mal nach seinen besten Tipps.  Die richtige Entscheidung, wie du selbst merken wirst. Nach der Folge werden auch deine nächsten Jahre prädestiniert sein, eine Ära ungeahnter Energie, Vitalität und strahlender Gesundheit zu werden. Viel Spaß mit diesem wirklich umfassenden Gespräch! Die Highlights der Episode: Die Kunst, jung zu bleiben: Du lernst, wie du trotz fortschreitenden Alters geistig und körperlich jung bleibst.  Biologisches vs. Chronologisches Alter: Wir diskutieren, wie aussagekräftig die biologische Altersmessung ist und wie Kraftraining unser biologisches Alter beeinflussen kann. Fitness-Strategien für die 40er: Andreas gibt wertvolle Tipps zu Fitnessübungen, die speziell darauf ausgerichtet sind, in den 40ern körperlich fit und beweglich zu bleiben, ohne die Gelenke zu überlasten. Die Rolle von Hormonen: Du erfährst, wie Hormone, einschließlich Testosteron, unsere Gesundheit und Fitness in den 40ern beeinflussen und wie wir sie optimal für unser Wohlergehen nutzen können. Unterschiede Männer und Frauen: Wir gehen auf die hormonellen Unterschiede bei der Fitnessoptimierung zwischen Mann und Frau ein. Schwermetallbelastung und Entgiftungsmethoden: Wir sprechen über die Auswirkungen von Schwermetallen auf den Körper und effektive Methoden zur Entgiftung. Die essentielle Bedeutung von Omega-3: Du erfährst, wie Omega-3 zur Gesundheit beiträgt und wie innovative Entgiftungsmethoden wie die INUSpherese oder Blutwäsche unterstützen können. Fruchtbarkeit als Gesundheitsindikator: Wir beleuchten, wie Fruchtbarkeit ein wichtiger Indikator für die allgemeine Gesundheit sein kann, besonders im fortgeschrittenen Alter. Supplements und Tools für gesunde Langlebigkeit: Andreas und ich diskutieren über die neuesten Möglichkeiten von Nahrungsergänzungsmitteln und Geräten, die speziell für die Langlebigkeit und Fitness in den 40ern entwickelt wurden. Wer ist Andreas Breitfeld? Andreas Breitfeld ist professioneller Biohacker und eine Schlüsselfigur in der Welt des Biohackings. Mit seiner jahrzehntelangen Erfahrung im Sportbereich (er war einer der allerersten Spinning-Instruktoren) und seinem Kampf mit einem schweren Burnout hat Andreas eine einzigartige Kombination an Fachwissen und persönlicher Erfahrung. Er ist Gründer des ersten Biohacking Labors im deutschsprachigen Raum und Autor zweier bahnbrechender Bücher über Biohacking. Sein umfassendes Wissen und seine praktischen Erfahrungen machen ihn zu einem unverzichtbaren Ratgeber für jeden, der seine Gesundheit und Fitness optimieren möchte. Entdecke die Kraft von Avea Life Damit mein Körper auch mit 40 noch das bekommt, was er für mein Traumleben braucht, greife ich schon seit geraumer Zeit auf hochwertige Nahrungsergänzung zurück, darunter NMN für den Energiestoffwechsel, Resveratrol, Fisetin, Quercetin und Spermidin für gesunde Zellen. Meine Wahl für diese besonderen und nicht so leicht zu bekommenden Wirkstoffe ist Avea Life. Ich konnte die Produkte der Firma über das vergangene Jahr ausgiebig testen und habe sie, nachdem ich mich überzeugen konnte, auch zum FlowFest 2023 nach München eingeladen, mit großem Erfolg! Warum ich die Produkte von Avea Life nehme Innovation und Qualität: Avea Life zeichnet sich durch innovative Produkte aus, die auf Spitzenqualität und Effektivität ausgerichtet sind. Gezielte Wirkstoffe: Die Palette von Avea Life bietet gezielt ausgewählte Inhaltsstoffe, die auf der aktuellen Forschung zur gesunden Langlebigkeit basieren und die deine Gesundheit und dein Wohlbefinden optimal unterstützen können. Exklusives Angebot für dich Als besonderes Angebot habe ich mit Avea Life einen Rabatt von 15% für dich arrangiert. Besuche hierzu einfach die Webseite https://avea-life.com/flowgrade und verwende den Code FLOWGRADE bei deiner Bestellung. Bis zum nächsten Mal und immer daran denken: Go for Flow.   Mehr Folgen mit Andreas Breitfeld: #160 - Wie du deine Gefühle selbst bestimmst #149 - Wie ein Biohacker dauerhaft fit bleibt #171 - Biohacking für Sportler   Folge mit Daniel Knebel: #37 - Über Entgiftung und warum Frauen mit Cardio nicht abnehmen   Weiterführende Links: Das Video zur Podcastfolge #192: https://youtu.be/7AxcsanGhlQ Webseite von Andreas: https://www.breitfeld-biohacking.com Bücher von Andreas Breitfeld: https://bit.ly/41bn8jd Andreas' Podcast: "Die Biohacking Praxis" Andreas' Instagram: https://www.instagram.com/breitfeld_biohacking Vitruvian: https://vitruvianform.com/ GlycanAge: https://glycanage.com/ EpiAge: https://www.epi-age.de/ Moleqlar: https://www.moleqlar.de/   Kontakt: Website https://www.flowgrade.de Flowgrade Instagram https://www.instagram.com/flowgrade Max Gotzler's Instagram https://www.instagram.com/max_gotzler Facebook https://www.facebook.com/biotrakr Twitter https://www.twitter.com/flowgrade LinkedIn https://www.linkedin.com/company/biotrakr Mail info@flowgrade.de

Last year, Dr. Brad Stanfield posted a video on why he stopped taking Fisetin and Quercetin, two of the most popular supplements in our longevity community. This comes in contrast to many other longevity experts such as Dr. David Sinclair, Dr Robbins, and Dr. Kirkland. This contradiction was based on a new Fisetin study conducted by the prestigious ITP organization showing no lifespan benefits nor senescent cell removal. And today, we'll do a very thorough investigation into the Study brad Stanfield mentioned. This study was conducted by an organization called the ITP. What is the ITP? What are their weaknesses that NOBODY speaks about? And what did they find in their fisetin study? We'll do data interpretation of the information that we do have. I have found something that shocked me about their study which I'll show you today. And what do I do with this information - do I take fisetin or shun it like Brad Stanfield? -------------------------------------------------------------------------------- ✅ Support on Patreon and Get BONUSES: https://www.patreon.com/WellnessMessiah --- Send in a voice message: https://podcasters.spotify.com/pod/show/wellnessmessiah/message

In 2022, Dr. Brad Stanfield posted a video in which he explained why he stopped taking Fisetin and Quercetin, two of the most popular supplements in our longevity community. This comes in total contradiction to the expert opinion of other longevity researchers, such as Dr David Sinclair, Dr. Paul Robbins , and Dr James Kirkland. Who's right? Who's wrong? I watched the video, and after researching about it, and finding pretty shocking things, I had to post my reply. And today, we'll do an investigation into Brad Stanfield's conclusion. We'll discover: - What are senescent cells and why they matter to your longevity? - What is the number one reason Brad stopped taking fisetin and quercetin? Then, I'll tell you what I really think about Dr. Brad Standfield and his channel. ---------------------------------------------------------------------------------------- ✅ Check Rimon's new updated longevity course: https://wellnessmessiah.com/course --- Send in a voice message: https://podcasters.spotify.com/pod/show/wellnessmessiah/message

Die Folge, die dich sterben lässt – aber noch später noch jünger. Denn Andreas gibt uns ein Update der Forschungen zum Thema Anti-Aging, Rejuvenation und Longevity. Überraschung: Es geht diesmal besonders liebevoll zu in der Biohacking Praxis.Der Partner der heutigen Episode heißt spermidineLIFE®. Mit ihrem Produkt spermidineLIFE® Boost+ unterstützt du deinen Körper bei der lebensnotwendigen Zellerneuerung, reduzierst den alltäglichen Stress undverjüngerst deine Zellen von innen heraus. Das Produkt kannst du dir gleich hier günstiger holen (15% Rabattcode: BFELD15).Peter Attias neues Buch zum Thema Anti Aging heißt „Outlive“, vorläufig nur auf Englisch erhältlich.Zum Nachhören: die erste Anti-Aging-Folge der Biohacking Praxis.Andreas hat Plyoboxen erwähnt, die beim Sprungtraining helfen, wenn das Telefonbuch keine Herausforderung mehr bietet. Andreas meint, dass diese hier ganz vernünftig ist. Die Themen Flexibilität und Knochendichte behandelt Andreas ausführlicher in seinem Buch „Biohacking für Sportler“. Gibt's überall, wo es Bücher gibt.Dominik Duschers Podcast heißt „Gesund & Gesund – Besser und länger leben“, die beiden Bücher mit Nina Ruge heißen „Altern wird heilbar“ und „Verjüngung ist möglich“.NMN, TMG (Betain) und Resveratrol: Donotage.org (15% Rabattcode: Yourbest) oder Moleqlar.de (10% Rabattcode: a.breitfeld).Fisetin und Urolithin: Donotage.org (15% Rabattcode: Yourbest).Informationen zu hochwertigen NAD+-Infusionen und anschließendem NAD+-Microdosing: anfrage@breitfeld-biohacking.com.Das Buch „Ab jetzt Biohacking“ von Andreas Breitfeld und Stefan Wagner erscheint im Mai 2023 bei ecowing. Vorbestellen kann man es hier.Das Buch „Viel Erfolg beim Misserfolg“ ist der Biohacking-Business-Ratgeber von Stefan Wagner, erschienen im Seifert Verlag, erhältlich hier.Andreas Breitfelds Website.Das ausführliche Porträt über Andreas Breitfeld in The Red Bulletin (Autor, übrigens: Stefan Wagner).Das Biohacking-Special, das Andreas Breitfeld und Stefan Wagner gemeinsam für The Red Bulletin INNOVATOR produziert haben.Stefan Wagners Biohacking-Kolumne im „carpe diem“.

Mit „Fast forward“ gewinnt Andreas den Wortspiel-Award der Woche. Und er verrät dir, mit welchen Hacks du schneller, tiefer, effizienter ins Fasten kommst. Von exogenen Ketonen bis Nüchterntraining, von Spermidin bis Mineralstoff-Supplements. Andreas und Stefan, diesmal im Stoffwechselturbomodus.Der Partner der heutigen Episode heißt spermidineLIFE®. Mit ihrem Produkt spermidineLIFE® Boost+ sorgen sie für ein gutes Bauchgefühl und eine innere Balance während deiner Fastenkur. Unterstütze den Fasteneffekt und hole dir das Produkt gleich hier.Exogene Ketone: Beim niederländischen Anbieter Ergomax gibt es welche ohne Multi-Level-Marketing-Anbindung.C8-Öl: Stefan versorgt sich bei Tulipans, Andreas schwört auf Flowgrade.Die unverschämt gut schmeckenden Essenziellen Aminosäuren von Julia Tulipan gibt es hier.Semaglutid und Metformin sind apotheken- und rezeptpflichtig. Berberin: Andreas nimmt 500mg (aber er vertraut keinem Anbieter so sehr, dass er ihn empfehlen möchte).Spermidin gibt es hier.Andreas' sauteure liebste LMNT-Mischung. Die preisgünstigere Antwort aus Deutschland.Fisetin, NMN, Resveratrol gibt es hier, der Code Yourbest bringt 15 Prozent pauschal auf alles.Mehr zum sehr spannenden Scheinfastenkurs von Julia Tulipan hier.Das Buch „Ab jetzt Biohacking“ von Andreas Breitfeld und Stefan Wagner erscheint im Mai 2023 bei ecowing. Vorbestellen kann man es hier. Das Buch „Biohacking für Sportler“ von Andreas Breitfeld erschien im Riva-Verlag und gibt es hier.Das Buch „Viel Erfolg beim Misserfolg“ ist der Biohacking-Business-Ratgeber von Stefan Wagner, erschienen im Seifert Verlag, erhältlich hier. Andreas Breitfelds Website.Das ausführliche Porträt über Andreas Breitfeld in The Red Bulletin (Autor, übrigens: Stefan Wagner).Das Biohacking-Special, das Andreas Breitfeld und Stefan Wagner gemeinsam für The Red Bulletin INNOVATOR produziert haben.Stefan Wagners Biohacking-Kolumne im „carpe diem“.

Chris Mirabile is a man on a mission. A man who has faced so much adversity in his life already.    Diagnosed at age 16 with a brain tumour, which spoiler alert he survived to tell the tale about, but also an entrepreneur and powerful spirit who experienced some extreme highs and lows, from being a high flying entrepreneur in the social media space with Hotlist to losing everything to rebuilding life and starting NOVOSLabs a biotech platform aimed at helping people stay younger longer.   He works with world leading scientists like Dr. George Church, PhD — Harvard Medical School & MIT Professor and Dr. Pamela Maher — University of British Columbia to formulate products and to educate on longevity science.    He has also personally been able to slow and even reverse his own age. By 13.6 years according to the "biological aging clocks" they use. You can follow his blog and  the results he publishes on his N of 1 experiments at https://slowmyage.com/   Novos Labs mission to help people live healthier for longer and in this episode Chris shares the research on a number of key longevity compounds like: Ca-AKG  Fisetin,  Rhodiola  Magnesium and more.   If you want to check out what they do at Novos Labs click the link here: https://novoslabs.com/?ref=6717   Do you want to know how to slow & even reverse aging, then this episode is for you!     Health Optimisation and Life Coaching with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clincian with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing  Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis She can help you navigate the confusing world of health and medicine and can advocate for you. She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whether you are facing challenges from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out.: Consult with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialised range of exclusive longevity, health optimising supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her mum but couldn't get in NZ. Check out the range at her LongLifeLabs shop   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books My latest book Relentless chronicles the inspiring journey of how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: Lisa's Books   Our NMN Bio Flagship Longevity Range A range by molecular biologist Dr Elena Seranova NMN: Nicotinamide Mononucleotide, an NAD+ precursor Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time.   What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today.   Support Your Healthy Aging We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: NMNBIO NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules   Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   Listen to the episodes with Dr Seranova on the show: https://www.lisatamati.com/podcast--dr-elena-seranova/ https://www.lisatamati.com/podcast--dr-elena-seranova-part-3/   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr MInkoff here:  Ketone Products by HVMN The world's best  exogenous Ketone IQ Listen to the episode with Dr Latt Mansor Lisa's  ‘Fierce' Sports Jewellery Collection For Lisa's gorgeous and inspiring sports jewellery collection, 'Fierce', go to Jewellery For Vielight Device Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com Use code "tamati" at checkout to get a 10% discount on any of their devices. Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa and team

2023 kann das gesündeste Jahr deines bisherigen Lebens werden! Meines bestimmt! Zuvor müssen wir verstehen, was unserem Körper schadet, wie wir altern und wie Krankheiten entstehen. Dann können wir unseren Lifestyle optimieren und einen gesunden Weg einschlagen. Zufriedenheit, eine hohe Vitalität und mehr Gesundheitsjahre in meinem Leben, das ist mein Ziel! Und du kannst es auch zu deinem Ziel machen. Ich werde dir dabei helfen!Let's go! Die Zeit wartet auf niemanden! Dein Optimizer Richard StaudnerPS: → Diesen Beitrag findest du auch im Rich Headroom Podcasts auf Spotify, Youtube, etc.→ Auf Instagram versorge ich dich laufend mit spannenden Biohacks rund um Health, Longevity und Performance! Besuch mich dort unter richard_staudner Powered by www.bioking.at - Der König der biologischen Lebensmittel!Hol dir 15% auf deine Bestellung mit dem Code “richard15”www.immunanalyse.at - Ganzheitliche Therapei und funktionelle Medizin in WienHol dir 5% auf deine Analyse mit dem Code “richard5”www.theartofraw.at - Teste die antioxdantien Bombe “Chaga” für dein Immunsystem!Hol dir 20% auf deine Bestellung mit dem Code “richard20”www.icebein.com - Eiskalt die Regeneration verbessern und schneller Gameready werden!Hol dir 5% auf deine Bestellung mit dem Code “richard5” 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.15.516580v1?rss=1 Authors: Mullen, M. T., Goff, A., Billings, J., Kloser, H., Huard, C., Mitchell, J., Hambright, W. S., Ravuri, S., Huard, J. Abstract: Mesenchymal stem cells (MSCs) have long been viewed as a promising therapeutic for musculoskeletal repair. However, regulatory concerns including tumorgenicity, inconsistencies in preparation techniques, donor-to-donor variability, and the accumulation of senescence during culture expansion have hindered the clinical application of MSCs. Senescence, in particular, is a driving mechanism for MSC dysfunction with advancing age. Often characterized by increased reactive oxygen species, senescence-associated heterochromatin foci, inflammatory cytokine and chemokine secretion, and reduced proliferative capacity, senescence directly inhibits MSCs efficacy as a therapeutic for musculoskeletal regeneration and repair. Furthermore, autologous delivery of senescent MSCs can further induce disease and aging progression through the secretion of the senescence-associated secretory phenotype (SASP) and mitigate the regenerative potentetial of MSCs. To combat these issues, the use of senolytic agents to selectively clear senescent cell populations has become popular. However, their benefits to human MSCs during the culture expansion process have not yet been elucidated. To address this, analyzed markers of senescence during culturing of human primary adipose-derived stem cells (ADSCs), a population of fat-resident MSCs commonly used in regenerative medicine applications. Next, we used the senolytic agent fisetin to determine if we can reduce these markers of senescence within our culture-expanded ADSC populations. Our results indicate that ADSCs acquire common markers of cellular senescence including increased reactive oxygen species, senescence-associated {beta}-galactosidase, and senescence-associated heterochromatin foci. Furthermore, we found that the senolytic agent fisetin works in a dose-dependent manner and selectively attenuates these markers of senescence while maintaining the differentiation potential of the expanded ADSCs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Lauren Alexander from Neurohacker Collective joined our podcast to discuss the science behind senolytics and how senescent cells play a role in aging. She shares how these "zombie cells" impact our immune system, joint health, cancer and longevity. We also discuss the best way to supplement with senolytics and why the "hit and run" strategy is so effective.Lauren Alexander is VP of Marketing at Neurohacker Collective, a company focused on making wellness products best known for their Qualia Mind supplement. Lauren is the mother of two young children, a passionate gardener and biohacker. Her areas of expertise include nootropics, biohacking, anti-aging, sleep and neurohacking.SHOW NOTES:0:51 Welcome to the show!3:15 Lauren Alexander's Bio4:05 Welcome Lauren to the podcast5:05 What is ‘cellular senescence'?8:52 Zombie cells10:41 Who is at risk of cellular aging?13:14 *Felix Gray Ad*16:57 Signs of a robust immune system18:10 STUDY: Qualia & Joint Pain19:23 Re-examining how we look at aging19:58 Senescent cells & Cancer21:09 Symptoms & signs to look out for22:55 Ingredients & Protocol in Qualia Senolytic28:40 Bioavailability and safety of supplements32:11 *SilverBiotics Ad*35:20 Should children use Senolytic?37:41 The hormetic effect of “hit and run”38:44 Biological Age Testing43:24 Should anyone not be taking it?43:59 Dosage & Frequency of supplementation44:36 Origin of the word ‘senolytic'45:30 Client benefits48:52 What about Fisetin?51:03 Her final piece of advice54:45 Renee's #1 Sleep Hack56:02 Lauren's #1 Sleep Hack57:28 Where to learn more about Neurohacker57:50 Thanks for tuning in!RESOURCES: Neurohacker.comShop: Qualia Senolytic - Save 15% with code BIOHACKERBABESIG: Neurohacker CollectivePilot StudyFelix Gray GlassesSilverBiotics - Discount code: BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donations

If you take resveratrol… did you know resveratrol works differently in your body depending on how much you take every day? If you're not careful about how you take resveratrol, you may achieve completely different benefits from the ones you intended! I couldn't believe it either until I saw in my own eyes. And it is one of resveratrol's biggest secrets. And it's kept within its polyphenol family. Which includes fisetin, quercetin, pterostilbene, and others. Today, we'll cover a hot topic in our longevity community: senescent cells. What are senescent cells? Are they so dangerous for longevity? For that, we'll hear Dr. David Sinclair, and Doctor James Kirkland, whom in my opinion, the world's greatest experts on senescent cells. Then, we'll explore the impact of resveratrol in different doses on senescent cells. We're also gonna cover fisetin and quercetin - what's the correct way to take them to kill senescent cells? And which dose current human studies are using them as senolytics? And as a response to your requests today I will share what I do personally - my resveratrol dose, when.... ....and my senolytics protocol - because of this investigation. ✅ Become a channel member on Patreon Starting with $1 and have access to the 10 resveratrol habits you can access now with all the tiny details. https://www.patreon.com/WellnessMessiah ✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery https://youtu.be/Js_l_G1x8V4 ✅ Part 2: “How RESVERATROL affects your heart?” https://youtu.be/yT4rqxADvQI ✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity? https://youtu.be/XFgSA7gbtus ✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study https://youtu.be/MNO4U5wbF08 ✅ Part 5: RESVERATROL MYSTERY: Why Taking Too Much HURTS Your Longevity https://youtu.be/cDTg2rCllM8 --- Send in a voice message: https://anchor.fm/wellnessmessiah/message

The author of one of my all-time favorite books recently released her second book, which was like Christmas coming early for me! Luckily, I had also met her before at an anti-aging conference and we have stayed in touch throughout the years. So I knew I had to Dr. Sandra Kaufmann on The Red Light Report for some amazing conversation about anti-aging and longevity strategies, especially as it relates to supplements and adjuvants —  topics that she is considered a bonafide expert. In her newest book, Aging Solutions, Dr. Kaufmann covers 28 different agents that she has found to be the most efficacious and backed by science, according to her rigorous research. We cover many agents from both of her books along with Dr. Kaufmann's skincare routine and other longevity hacks she as implemented over the years, including red light therapy!Dr. Sandra Kaufmann began her academic career in the field of cellular biology, earning a Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. She has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital for 9 years, a nationally recognized center of excellence.Dr. Kaufmann's avid interest in the science of anti-aging begun many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first ever, comprehensive theory of aging. She has now released two books on longevity: The Kaufmann Protocol: Why We Age and How to Stop it, and just recently in 2022, Aging Solutions. This conversation could have easily gone on for hours and hours, as Dr. Kaufmann is a wealth of knowledge in some of my favorite topics and is fun to listen and learn from. I know you will all enjoy learning from her like I did and, if so, I highly recommend you check out BOTH of her books. They are simply amazing resources of anti-aging/longevity information. As always, light up your health! - Dr. Mike Belkowski & Dr. Sandra Kaufmann discuss the following: 3:16 - Her reasoning for jumping into anti-aging and longevity 3:29 - RAADfest - October 2022 in San Diego 8:05 - Supplements vs. adjuvants 9:27 - How people confuse deficiency with longevity 10:57 - Bioavailability and resveratrol  12:15 - Bringing natural remedies back into the light 15:00 - The five basic agents of the Panacea 15:27 - Astaxanthin and its benefits for free radical scavenging 16:33 - The blood-brain barrier 16:53 - Nicotinamide and why it's crucially important for longevity 17:42 - Anti-inflammatories for longevity 18:05 - Glycation 19:15 - Eye health and vision 19:50 - Carnosine eyedrops 21:35 - Eye health and red light therapy 22:38 - Goggles vs. no goggles with red light therapy 25:46 - Supplements and adjuvants she is most excited about 27:10 - Spermidine and how it prevents DNA damage 29:34 - The mitochondrial transition permiability pore 31:36 - Fisetin for longevity 33:22 - Senescent cells (zombie cells) 36:41 - Metformin vs. berberine 38:44 - Glycation and how to defeat it 39:05 - How her diet doesn't affect her good lab results 42:41 - Her anti-aging and longevity regiment 46:06 - Skin health 51:46 - UV exposure to the skin 54:25 - Starting treatments earlier vs. later 59:08 - Micronutrient deficiencies and getting older 1:00:09 - Newfound discoveries - Watch this episode on YouTube - Where to Learn More From & About Dr. Sandra Kaufmann:   Website: KaufmannProtocol.com   Instagram: @KaufmannAntiAging   - Books written by Dr. Sandra Kaufmann:   Aging Solutions (2022)   The Kaufmann Protocol (2017)   - Check out the Kindle version of Red Light Therapy Treatment Protocols eBook, 4th Edition - To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Instagram YouTube

Jerry Hickey, Ph dives into research about the importance of Quercetin and how the supplement helps the Anti-Aging process. Take advantage of an exclusive podcast offer today by visiting http://www.invitehealth.com/podcast. For more information on the products or studies mentioned in this episode, as well as a complete transcript of the audio, click here

Videos: 1. The great recycling LIE (what really happens to plastic) (10:44) 2. Is It Game Over? New NASA Report (5:30) 2. You won't believe what Justin Trudeau's government just did | Redacted with Clayton Morris (13:26) 3. Neil Oliver – Who pulls the strings – Pandemic Treaty, Wealth & Power? (2:00) 4. He's EXPOSING the truth in Syria and they don't like it | Redacted conversation w/ Kevork Almassian (first 10:00) 5. Russian Ruble now best performing currency in the world this year… another example of how US sanctions have failed. 6. Vanessa Beeley and Eva Bartlett are smeared by the Guardian for reporting the truth (3:07) 7. Kim Iversen: Inside The SECRET Bilderberg Meetings Between Spies, War Hawks And World Leaders (9:28) 8. New Rule: The Misinformation Age | Real Time with Bill Maher (HBO) 9. https://theduran.locals.com/post/2311112/title  10. https://www.youtube.com/watch?v=3maIN4-ZJl8    Strawberry Compound Shown to Protect Against Alzheimer's, Memory Loss Salk Institute for Biological Studies, June 16, 2022  The thought of losing your mind is a frightening one, but one in three Americans die with Alzheimer's or some other form of dementia. Regardless how frightening the possibility is, the chances of it happening to you aren't exactly slim, which means prevention should be at the forefront of your mind. A recent study from the Salk Institute for Biological Studies indicates prevention could be as simple as a natural foods diet—rich in fruits (such as strawberries) and vegetables containing something called fisetin. Fisetin is a flavonol found in strawberries, mangoes, cucumbers, and other vegetables and fruits. Researchers with the Salk Institute found this simple compound can actually reduce the risk of Alzheimer's in mice, and could be effective in humans as well. Maher and her team have documented that fisetin has both anti-inflammatory and antioxidant properties in the brain. It is also able to turn on a cellular pathway related to memory function. The team looked to a type of mouse with mutated genes making them vulnerable to Alzheimer's. At three months old, the researchers began feeding the mice a diet enriched with fisetin. Mice who hadn't received the fisetin began struggling in the mazes at nine months of age, but the fisetin mice performed as well as normal (non-predisposed) mice at both nine and twelve months of age. Avocados may hold the answer to beating leukemia University of Waterloo (Canada), June 16, 2022 Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer. Professor Paul Spagnuolo from the University of Waterloo has discovered a lipid in avocados that combats acute myeloid leukemia (AML) by targeting the root of the disease – leukemia stem cells. Worldwide, there are few drug treatments available to patients that target leukemia stem cells. “The stem cell is really the cell that drives the disease,” said Professor Spagnuolo, in Waterloo's School of Pharmacy. “The stem cell is largely responsible for the disease developing and it's the reason why so many patients with leukemia relapse. We've performed many rounds of testing to determine how this new drug works at a molecular level and confirmed that it targets stem cells selectively, leaving healthy cells unharmed.” Inability to stand on one leg for 10 seconds in mid to later life linked to near doubling in risk of death Exercise Medicine Clinic-CLINIMEX (Brazil) and University of Eastern Finland, June 21, 2022 The inability to stand on one leg for 10 seconds in mid- to later life is linked to a near doubling in the risk of death from any cause within the next 10 years, finds research published online in the British Journal of Sports Medicine This simple and safe balance test could be included in routine health checks for older adults, say the researchers. The researchers wanted to find out whether a balance test might be a reliable indicator of a person's risk of death from any cause within the next decade, and, as such, might therefore merit inclusion in routine health checks in later life. Participants were asked to stand on one leg for 10 seconds without any additional support.  To improve standardization of the test, participants were asked to place the front of the free foot on the back of the opposite lower leg, while keeping their arms by their sides and their gaze fixed straight ahead. Up to three attempts on either foot were permitted. In all, around 1 in 5 (20.5%; 348) participants failed to pass the test. The inability to do so rose in tandem with age, more or less doubling at subsequent 5 year intervals from the age of 51-55 onwards.  The proportions of those unable to stand on one leg for 10 seconds were: nearly 5% among 51-55 year-olds; 8% among 56-60 year-olds; just under 18% among 61-65 year-olds; and just under 37% among 66-70 year-olds.  More than half (around 54%) of those aged 71-75 were unable to complete the test. In other words, people in this age group were more than 11 times as likely to fail the test as those just 20 years younger. During an average monitoring period of 7 years, 123 (7%) people died: cancer (32%); cardiovascular disease (30%); respiratory disease (9%); and COVID-19 complications (7%). The proportion of deaths among those who failed the test was significantly higher: 17.5% vs. 4.5%, reflecting an absolute difference of just under 13%. Anxious Children have Bigger “Fear Centers” in the Brain Stanford University School of Medicine, June 16, 2022 The amygdala is a key “fear center” in the brain. Alterations in the development of the amygdala during childhood may have an important influence on the development of anxiety problems, reports a new study in the current issue of Biological Psychiatry.

 Researchers at the Stanford University School of Medicine recruited 76 children, 7 to 9 years of age, a period when anxiety-related traits and symptoms can first be reliably identified.  The researchers found that children with high levels of anxiety had enlarged amygdala volume and increased connectivity with other brain regions responsible for attention, emotion perception, and regulation, compared to children with low levels of anxiety. They also developed an equation that reliably predicted the children's anxiety level from the MRI measurements of amygdala volume and amygdala functional connectivity.

The most affected region was the basolateral portion of the amygdala, a subregion of the amygdala implicated in fear learning and the processing of emotion-related information.

 Our study represents an important step in characterizing altered brain systems and developing predictive biomarkers in the identification for young children at risk for anxiety disorders,” Qin said.  New research: Olive oil compound destroys cancer cells in 30 minutes Rutgers University & Hunter College, June 12, 2022  Oleocanthal, a polyphenolic, therapeutic compound found in olive oil is the subject of a new anti-cancer study performed by nutritional science and cancer biology researchers with The School of Environmental and Biological Sciences at Rutgers and Hunter's College in New York City. Programmed cell death, known as apoptosis takes approximately 16-24 hours. Dynamic new research just published in the Journal of Molecular and Cellular Oncology blew scientists away – when exposed to oleocanthal, a polyphenol compound found in olive oil, cancerous cells died within 30 minutes to an hour. While researchers previously understood that compounds in olive oil were capable of killing cancer cells, until now, such short apoptosis had not been observed. Even more fascinating was when the team looked closely to surmise why apoptosis was occurring under such swift circumstances – they discovered that cancer cells were being killed by their own enzymes. And, not only one isolated type of cancerous cell, but all of the cancerous cells they were examining. Unlike chemotherapeutic pharmaceuticals that devastate healthy cellular activity, the therapeutic polyphenolic compound found in olive oil kills cancer while maintaining vitality among healthy cells. As Paul Breslin, one of the study's authors at Rutgers noted, while cancerous cells died, healthy cells were not harmed, but rather the oleocanthal “put them to sleep.” The lifecycle of healthy cells was only temporarily affected in this way, without any negative observations and in approximately 24 hours, the healthy cells resumed their life cycle.  Sports, not screens: The key to happier, healthier children University of South Australia, June 21, 2022 Whether it's sports practice, music lessons or a casual catch up with friends, when children are involved in after-school activities, they're more likely to feel happier and healthier than their counterparts who are glued to a screen. In a new study conducted by the University of South Australia, researchers found that children's well-being is heightened when they participate in extra-curricular activities, yet lowered when they spent time on social media or playing video games. Published in BMC Pediatrics, the study analyzed data from 61,759 school students in years 4 to 9, assessing the average number of days per week children participated in after-school activities (3–6pm), and measure these against well-being factors—happiness, sadness, worry, engagement, perseverance, optimism, emotion regulation, and life satisfaction. It found that most students watched TV about four days of the school week and spent time on social media about three days of the week. Our study highlights how some out-of-school activities can boost children's well-being, while others—particularly screens—can chip away at their mental and physical health. “Screens are a massive distraction for children of all ages. And whether children are gaming, watching TV or on social media, there's something about all screens that's damaging to their well-being. Students in lower socio-economic backgrounds who frequently played sports were 15% more likely to be optimistic, 14% more likely to be happy and satisfied with their life, and 10% more likely to be able to regulate their emotions. Conversely, children who played video games and used social media almost always had lower levels of well-being: up to 9% less likely to be happy, up to 8% to be less optimism and 11% to be more likely to give up on things.

We don't often look at preventative measures when it comes to our health. We typically look for ways to get better after we get sick — take a pill or undergo this operation, and everything will be better! Don't put off becoming more health-conscious until you've been diagnosed with a disease like cancer. The adage still holds: prevention is better than a cure. In this episode, Best Selling Science Author++ Travis Christofferson discusses the root causes of diseases and how we can take a preventive approach to health. He shares emerging cancer treatment research and encourages us to learn more about them. Focus on your overall health rather than specific diseases. When your body has a good immune system, it can help prevent illnesses like cancer!  If you want to learn more about the latest in cancer research disease prevention, then this episode is for you! Here are three reasons why you should listen to the full episode: Understand the root causes of diseases and how we can prevent them rather than waiting for illness. Learn about emerging cancer treatment research, including the metabolic approach, ketosis, abscopal effect, etc.  The state of our health care systems Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and not getting anywhere with the traditional medical system and need people who look outside the square who are up on the cutting edge of research and are connected to some of the greatest science and health minds in the world? Then reach out to us at lisa@lisatamati.com, we can jump on a call to see if we are a good fit for you. Mindset and Mental Toughness coaching. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at lisa@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplement Range NMN: Nicotinamide Mononucleotide, an NAD+ precursor Quercetin and Trimethlyglycine by NMN Bio Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. ​100% vegan and non-GMO. ​The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! ​No other form of protein comes close to PerfectAminos Ketone Products by Keto-Pro Exogenous Ketones developed by Nutritionist and Body Building champion Richard Smith. Keto-Pro BHB Exogenous Ketones –  250g   MORE BHB per gram than other MARKET LEADERS. During In-house testing, Keto-Pro BHB raised ketones quicker, higher and for longer than other market leaders. Ketones My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [03:17] Travis' Background Travis has an undergraduate degree in biochemistry. He eventually took over the family business and got married.  He then finished his master's degree, focusing on cancer metabolism for his independent study. The prevailing teaching during that time was that somatic mutations cause cancer. Travis was inspired by the book, Cancer as a Metabolic Disease, to do a thesis on metabolic theory.  Otto Warburg proposed the metabolic theory many years ago, but the medical community dismissed it as simplistic. New evidence reignited interest in the approach. [08:10] The State of Healthcare Public and health institutions have long accepted the somatic approach to cancer, with billions of dollars backing it.  The United States spends the most per capita on health care expenditure among developed countries yet has the lowest life expectancy.  The issue with the healthcare system lies in variations of treatment, over-treatment, and drug development process.  The healthcare industry is focused more on treating diseases rather than preventing them.   Although technology has advanced to assist people in tracking their health, people's health is deteriorating. Even if people live longer, they often experience illness and disability in their final years. [12:48] Changing the Healthcare Industry  The healthcare incentive structure must change. Doctors get paid for every drug and procedure they prescribe, leading to overtreatment.  There are emerging practices where doctors get a big bonus per patient who doesn't need procedures, encouraging them to keep patients in good health. When blood sugar levels rise, doctors usually diagnose diabetes. However, we can test for fasting insulin regularly to intervene. This test can also help people prevent other diseases and become more health-conscious. Change takes time with systems and industries, but we can take simple lifestyle interventions now. [16:01] Why People Are Getting Sicker Maintaining our health can be challenging. We've been conditioned that taking a magic pill is preferable to putting in the effort. Remember that metabolic dysregulation causes aging, not the other way around. In the last 10,000 years, humanity has drastically shifted to consuming processed foods, carbohydrates, and oils, resulting in noticeable consequences. People have also become sedentary.  A hunter-gatherer society has no obesity, insulin resistance, or chronic systemic inflammation. However, we frequently see this in the Western world. [20:32] The Root of Diseases  Understanding cellular health and inflammatory processes are critical in keeping yourself healthy.  Periods of food scarcity have happened throughout humanity's evolution. Our bodies enter ketosis due to the caloric deficit but most never reach this state. Studies have shown that ketosis can help prevent diseases ranging from Alzheimer's to Parkinson's to cancer and diabetes. Constantly eating keeps our immune system active and prevents it from resting, which has implications for chronic inflammatory diseases. [24:53] What Happens During Ketosis?  Ketosis happens in a fasted state, and a ketogenic diet is nutritional maintenance. When we fast, our bodies will mobilise the fat we have in our bodies and begin a process of beta-oxidation to burn off fat.  A caloric deficit makes this process faster, converting fats into ketone bodies, which then take the place of glucose.  Ketones have more thermodynamic energy and ATP per carbon unit compared to glucose.  Ketosis also boosts antioxidant levels. Since diseases are oxidative, ketosis can help to combat illnesses. Listen to the episode to learn more!  [32:01] Growing Healthcare Trends  Research has shown that fasting before chemotherapy can reduce some radiation side effects Sugar is fuel for cancer cells, but doctors continue giving and allowing patients to consume it.  There's more awareness of the latest research. The annual Metabolic Therapeutic Conference has grown to around 1600 attendees.    When we approach doctors, we will receive information their institution has taught and allowed them to give us. Even with COVID-19, people have yet to explore treatments like monoclonal antibodies, hyperbaric, and Vitamin C.  [44:00] The Abscopal Effect on Cancer The abscopal effect is when you target a single tumour site, but it affects other tumour sites in the body.  Travis shares a case where someone with breast cancer on a checkpoint inhibitor received a much lower radiation dose.  In that case, radiation was sufficient to systematically stimulate the immune system to attack cancer, improving the patient's chances of survival. [47:41] Advancements in Immunotherapy Using peptides to manipulate the immune system is still a trial and error process. The immune system's job is to survey for cancer, get rid of it early, and create a checkpoint to avoid attacking itself.  [49:44] Emerging Cancer Treatment Research In detection, metastasis is an early stage event rather than a late-stage one. Cancer cells break off, dying when it reaches the bloodstream.  This selection pressure creates different genetic mutations in tumours.  The somatic mutation theory argues that a series of sequential mutations cause cancer, with each tumour site having a unique set of driving mutations. The epigenetic metabolic theory posits that these mutations are a side effect of the disease.  All cancers burn sugar and evade the immune system, but mutations vary too much. Treatments should focus on epigenetic expression rather than mutations. [55:16] Researching Treatment Options The medical field is filled with uncertainty. Cancer treatment options have not been compared.  After an in-depth look at clinical trials, we find that what seems to be the best treatment paradigm isn't always the right option. When conducting research, consider the data and evaluate it using a risk-reward framework. You can choose from low-risk alternatives. [59:59] The Soil Approach to Cancer  Cancer grows in the presence of a favourable microenvironment and molecular events. It takes a long time for a chronic irritant to develop cancer cells. Cancer cells take on characteristics of our earliest genes,  including replication and the appearance of early embryos. You can help your cells "behave" by providing oxygen and avoiding chronic irritants. Nurture the microenvironment through exercising and eating the right foods.  Instead of focusing on the seed or cancer, we should concentrate on the soil or microenvironment. [1:04:05] Health and Longevity While we don't know humankind's natural and optimal states, ketosis and fasting provide a glimpse. Cells stop metabolising as we age, causing inflammation. We may be able to extend life spans if we can reduce senescent cells. Travis shares a study in which mice received fisetin, found in strawberries, reducing senescent cells and prolonging their life.  There's a lot of new research on substances that kill senescent cells, like senolytics, quercetin, and other compounds. [1:08:49] About StageZero Life Sciences  StageZero Life Sciences looks into markers of inflammation, insulin resistance, etc. They also recommend potential lifestyle interventions to change those markers.  They are currently available in Richmond, Virginia, Toronto, and Ontario, Canada. 7 Powerful Quotes 'It's just a combination of probably a terrible diet and just not moving enough because we were designed to go out and have to work every day to catch food. That's what we evolved, and when you uncouple your physiology from that environmental niche, you see all kinds of problems' ‘It appears that evolution has built in a powerful signal to that when you're in a caloric deficiency, you switch your metabolism…to something called ketosis where you completely shift what you're burning to these little small molecules that come from fat,' ‘We're terrible at focusing on prevention. We focus on the disease, trying to treat it once it's already manifest, which is an absolutely horrible strategy.' ‘If we look at cancer then as the prime drivers being metabolic and epigenetic, that means that all of those things potentially could be modifiable, right? We don't have to target mutations. We can look for ways to change the way cells are expressing genes and so forth, and metabolising substrates and things like that.' ‘Just mind the microenvironment of your body, which is giving you the right food, exercising. It's designed to do that. Every time you do that, it brings down those inflammatory processes, and so forth.' ‘We tend to think we're in this modern era, but with regard to cancer, we will look back 200 years from now, realise that we were just in the Dark Ages. We're still using radiation which was invented about 110 years ago; chemotherapy was invented around World War II. That's still the mainstay of cancer treatments.' ‘When you really look deep, the two problems really are variation in treatment, over-treatment. The drug development process, I think, is one of the main problems too,' Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Want to learn more from Travis? Check out his books:  Tripping Over the Truth: How the Metabolic Theory of Cancer is Overturning One of Medicine's Most Entrenched Paradigms  Curable: How an Unlikely Group of Radical Innovators is Trying to Transform our Health Care System Ketones, The Fourth Fuel: Warburg to Krebs to Veech, the 250 Year Journey to Find the Fountain of Youth The Origin (and future) of the Ketogenic Diet, co-authored with Dr Dom D'Agostino   Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer by Thomas Seyfried  Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee The Cancer Code: A Revolutionary New Understanding of a Medical Mystery by Dr Jason Fung  Healthy Conversations With Travis Christofferson and Guest, Jason Fung M D from StageZero Life Sciences   Check out these previous episodes with Dr Elena Seranova:  Episode 238 - Reverse Ageing to Live Longer and Healthier Episode 189 - Understanding Autophagy and Increasing Your Longevity Episode 183 - Sirtuins and NAD Supplements for Longevity    Learn more about cancer and health through our previous episodes:  The Six Cornerstones for Better Health with Dr Charles Meakin Cancer Revolution: The Metabolic Approach to Cancer with Maggie and Bradley Jones   Abscopal effect following radiation monotherapy in breast cancer: A case report Fisetin is a senotherapeutic that extends health and lifespan Short-term fasting accompanying chemotherapy as supportive therapy in gynecological cancer: protocol for a multicenter randomised controlled clinical trial StageZero Life Sciences: Website | AVRT Program Foundation for Metabolic Cancer Therapies    Connect with Travis:  LinkedIn | Twitter | Facebook    About Travis  Travis Christofferson is the founder of The Foundation for Metabolic Cancer Therapies and works in Clinical Development at StageZero Life Sciences Ltd.  He is also a science author of several books, including Tripping Over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms, Curable: How an Unlikely Group of Radical Innovators Is Trying to Transform Our Health Care System, Ketones, The Fourth Fuel, and co-author of The Origin (and future) of the Ketogenic Diet.  Want to learn more about Travis' work? Check out Foundation for Metabolic Cancer Therapies.  You can also connect with him on LinkedIn, Twitter, and Facebook.    

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I've had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements. In today's episode, you will learn: - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more - Richard's thoughts on lifespan vs. healthspan All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld RICHARD MILLER LINKS: Website: http://www.richmillerlab.com/ Photography: https://richardmiller.zenfolio.com/ Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:55 Richard Miller Intro 1:51 Richard Miller Wildlife photography 3:30 ITP - the gold standard for testing longevity drugs & winning drugs 10:51 Rapamycin, Rapamycin + Acarbose 18:48 Rapamycin + Acarbose Dosing Schedule 20:15 Combination of drugs, Rapamycin + Metformin 21:56 17-Alpha Estradiol 25:45 Canagaflozin 31:34 Does Richard take the 4 winning drugs? 32:46 3 Drugs that have small lifespan effects & promising 36:30 GPLD-1 & shared mechanisms in longevity drugs 44:04 Resveratrol in ITP 46:27 NR, NMN 52:34 Curcumin, Green Tea Extract, MCT Oil 54:54 Fisetin & Senolytics 56:12 Why most published research findings are false 1:00:03 Healthspan biomarkers at the ITP 1:02:38 Can you have healthspan without lifespan? 1:07:37 Fish Oil, Spermidine, Sulforophane 1:12:13 Unpublished data Richard is excited about 1:17:47 Flying Pigs & Aubrey De Grey 1:20:00 Exponential rise in aging research Episode Show Notes: https://livelongerworld.substack.com/p/rmiller Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight.

Rapamycin, metformin, and fisetin are all associated with improvements in markers associated with aging. We are now beginning to see them used by healthy individuals interested in longevity. Daniel Tawfik is the founder, developer, and CEO of HealthSpan. HealthSpan optimizes human performance through interventions that target cellular senescence. Healthspan was created to empower patients to regain control over the levers of aging that are at the foundation of most age-related diseases.Daniel holds a BS degree from UCLA in molecular, cellular, and developmental biology and physics. Daniel did his graduate research at UCLA's Protein Expression Technology Center where he studied neurometabolic disorders. http://dantawfik.com/Gethealthspan.com @dantawfikhttps://zenpatient.com/ Support the show (https://robert-lufkin.mykajabi.com/membership)

Longevity, Anti Aging, Rejuvenation: Der Gesundheits-Megatrend verspricht, dass wir alle 120 Jahre alt werden können. Andreas Breitfeld verrät uns, wie unglaublich weit die Wissenschaft schon ist, was du selbst tun kannst, um jeden Tag jünger zu werden. Und welche Super-Supplements er selbst nimmt. Du willst mehr wissen? Hier die Shownotes zu dieser Folge der Biohacking-Praxis: Die erwähnte Story über Michael Greve aus dem Red Bulletin Innovator findest du hier zum Nachlesen: https://www.redbull.com/de-de/theredbulletin/michael-greve-biohacking-langlebigkeitDavid Sinclairs erwähntes Buch zum Thema heißt „Das Ende des Alterns“, sein ebenfalls erwähnter Podcast heißt „Lifespan“: https://www.lifespanpodcast.com Andreas Breitfeld verwendet diese erwähnten Produkte: Fisetin Doctor's Best, Fisetin mit Novusetin, 1500mg an 2 aufeinander folgenden Tagen pro Monat NMN AEFGA 1-2 Gramm morgens Resveratrol AEFGA 1-2 Gramm morgens Metformin 850 mg abends Spermidine Life Immune 4 Kapseln täglichStefan Wagner verwendet folgende Produkte: Pure Fisetin, Hansen Supplements, jeweils am 15. und 16. des Monats 1500 mgSpermidin, Moleqlar, täglich 1-2 Kapseln NMN, Moleqlar, täglich ca. 800 mg-1 gResveratrol, Moleqlar, täglich ca. 800 mg-1 gWilson Blade 101L, nach Möglichkeit 3 x wöchentlich Andreas Breitfelds Website: https://breitfeld-biohacking.com Das ausführliche Porträt über Andreas Breitfeld in The Red Bulletin (Autor, übrigens: Stefan Wagner): https://www.redbull.com/at-de/theredbulletin/biohacking-andreas-breitfeld Das Biohacking-Special, das Andreas Breitfeld und Stefan Wagner gemeinsam für The Red Bulletin Innovator produziert haben: https://issuu.com/redbulletin.com/docs/0221_trbi_at_lowres Stefan Wagners Biohacking-Kolumne im „carpe diem“: https://www.carpediem.life/wagner

In this video Dr. Kirkland talks about the future of aging and how the biology of aging affects everyone and should not be thought of as only relevant to older people. He also discusses the path of bringing senolytics to wider use. Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism. If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this video Dr. Kirkland talks about what we can do to reduce our senescent cell burden with lifestyle choices and how there is a grouping of health organizations measuring health markers across multiple trials to gather data on aging. Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism. If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this video Dr. Kirkland talks about the senolytics that the Mayo Clinic is using in the on going trials, dasatinib, Fisetin and Quercetin. He also talks about the way the work and the schedule to taking them Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism. If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this video Dr. Kirkland talks about how and why senescent cells are formed, how they can be removed and what the benefits of removing them is. Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism. If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this video Dr. Kirkland gives a wide introduction to senescent cells including why we have them, what purpose they serve and what damage they can cause. Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism. If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this video Dr. Kirkland explains his theory of aging and discusses the Unitary Theory of Fundamental Aging, which posits that there are underlying pillars of aging which cause the diseases of aging and that are interlinked. Dr. Kirkland offers some examples of these linkages Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism. If you would like to support our channel, we'd love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

In this week's episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Matthew LaPlante's Social: Twitter Timestamps: (00:00:00) Kicking Off Episode Four: Longevity Molecules (00:02:15) Thanks the Sponsors (00:04:46) An An Additional Boost Beyond Adversity Mimetics (00:05:52) Drugs vs. Supplements and Highlight Points (00:09:54) Longevity Molecules Target the Survival Circuit (00:11:33) NAD Boosters (00:13:32) Nicotinamide Riboside (00:21:26) Nicotinamide Mononucleotide (00:29:22) NAD Intravenous Drips (00:32:45) Bioavailability of NAD Boosters (00:33:40) NAD and Cancer (00:35:33) Resveratrol (00:42:26) Red Wine and the French Paradox (0043:08) Fisetin and Quercetin (00:47:09) Rapamycin and Rapalogs (00:49:10) Spermidine (00:51:27) Metformin (01:00:27) Berberine (01:02:43) Dr. Sinclair's Protocol for Longevity Molecules (01:08:51) Wrap-up and Next Week's Episode: Interventions on the Cutting Edge (01:09:52) Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Supplement Engineer Blog: https://supplementengineer.com/blogs/supplements Business inquiries: thesupplementengineer@gmail.com   Formulator and Chief Science Officer of Glaxon, Joey Savage, rejoins the podcast to take a DEEP dive into the latest product offerings from Glaxon as well as discuss all things supplements, nootropics, and formulation science. Show Notes Catching up on all things new at Glaxon Protos Vegan Protein Why use a 70/30 ratio of whey and casein in Protos? Benefits of English ivy leaf extract Inside Goon Mode & Neuro365 What is Fisetin? Best carb supplements Inside Xerion Where to Find Joey & Glaxon Joey Savage IG: https://www.instagram.com/supplementlab/ Glaxon IG: https://www.instagram.com/iamglaxon/ Glaxon Website: https://www.glaxon.com Save 20% on Glaxon Supplements Use code "SAVAGE" for 20% off Glaxon supplements at https://www.glaxon.com Before You Go... If you enjoy this podcast and want to see more content like it, please consider leaving a review!   https://itunes.apple.com/us/podcast/supplement-engineer-podcast/id1447389041?mt=2&ls=1

The antioxidant nutrient, Fisetin, is found in many common fruits and vegetables. It has far-ranging benefits as an anti-inflammatory, plus anti-aging, cardiovascular, memory, and other properties. Animal studies suggest it may also reduce mortality from COVID.

＜お知らせ＞◆Clubhouse イベント：ぜひご参加ください！ ◆６月３日２２：１０~（やってみよう手作り食！トッピングのしかた） ⇒　https://bit.ly/3yTHL4Q 結論：お野菜・果物のトッピングはお勧めです^^ 目安量についても簡単に解説！ ＜おススメ音声＞ ◆himalaya #292. 腸活：ウンチが実際によくなったサプリは？おススメの食材は？（Clubhouse コラボ対談 No.3） ⇒　https://bit.ly/3vHPwsW ◆Clubhouse クラブ【ペットのホリスティックケア】 ⇒　https://bit.ly/3tXtMbn ◆Clubhouse始めました！ ↓ 探してみてネ ↓ アカウント名：ホリスティック獣医Sara (@holistic_sara) 著書： 【ペットのお悩み解決！メール相談室：犬猫に長生きしてもらうためのホームケア】 ◆電子版（Kindle）：https://amzn.to/3cR7kIa ◆一般（ペーパーバック）：https://amzn.to/2W7C94I ◆質問箱を設置しました！ ペットの健康に関する気になることなど、なにかありましたらお気軽にコメントください。 ラジオ番組内でお答えさせていただきます。 ⇒　https://peing.net/ja/sarapa101mayu Attribution: Otologic, https://otologic.jp Dova syndrome, https://dova-s.jp 往診専門 Saraホリスティックアニマルクリニック DVM(獣医師) / 英国VetLFHom　濱田真由美（Sara） ウェブサイト等: https://linktr.ee/holisticvet.sara References - Wang DD, et al. Fruit and vegetable intake and mortality: results from 2 prospective cohort studies of US men and women and a meta-analysis of 26 cohort studies. Circulation 2021; 143(17): 1642-1654. - Yousefzadeh MJ. et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 2018; 36: 18-28. ーコメント・シェアはお気軽にどうぞー ホリスティック獣医Saraでした

My guest this week is Russell Kane, a Multi-award-winning comedian, presenter, actor, author and scriptwriter. Russell Kane is best known for the BBC Radio 4 podcast Evil Genius, which has become a flagship show and was the best performing original podcast on the BBC Sounds platform. Russell's other podcast, Boys Don't Cry, also features regularly on the iTunes podcast chart. Kane is also the author of two books, “The Humorist” and the very well-received memoir about his father “Son of a Silverback: Growing Up in the Shadow of an Alpha Male”. He was also the winner of Best Show in 2010 at the Edinburgh Comedy Awards, Russell went on to make history as the first comedian to win both the Edinburgh Award and Melbourne Comedy Festival's Barry Award in one year.In this conversation you see the less funny side of Russell, it is however one of the most informative, fascinating and mind-boggling conversations i've ever had on this podcast. This guy has more knowledge than you could ever imagine and I think you’re really going to enjoy this chat.  Topics: Your Dad Are you worried you'll turn into your Dad?  How do we become more self-aware? How does someone become successful?  Personal responsibility  Is there no hope for some people?  Why did you become a comedian?  How do you overcome nerves?  Relationships, evolution of one & cheating Biohacking  What you're up to  Russell’s Biohacking list: 750g NMN (double wood) 1g of Trans-Resveratrol (not just Resveratrol) - Vitafair is good 20mg pqq Vitamin D3 Max DHA fish oil 100mg Fisetin (double wood) Weekly dose of Extension Senolytic Activator Russel:https://twitter.com/russell_kane https://www.instagram.com/russell_kane/ Sponsor: uk.huel.com  

The Gary Null Show is here to inform you on the best news in health, healing, the environment.  If you would like to sign up for the new PRN Newsletter provide your email to Prnstudio@gmail.com   Professor Sunetra Gupta: the epidemic is on its way out Brendan O'Neill: The danger of the 'chattering class' Link confirmed between healthy diet and prostate cancer prevention University of Calgary, August 6, 2020   The Canadian Cancer Society estimates that more than 23,000 Canadians will be diagnosed with prostate cancer in 2020. Among other risk factors, more and more studies point to diet as a major factor in the development of prostate cancer, as it is for cardiovascular disease, diabetes, and obesity. Using data from a study conducted in Montreal between 2005 and 2012, a research team led by Professor Marie-Elise Parent of Institut national de la recherche scientifique (INRS) has shown a link between diet and prostate cancer in the article “Dietary Patterns Are Associated with Risk of Prostate Cancer in a Population-Based Case-Control Study in Montreal, Canada”, published in Nutrients in June. Three main dietary profiles analyzed INRS PhD student Karine Trudeau, the lead author of the study, based her analysis on three main dietary profiles: healthy diet, salty Western diet including alcohol, and sugar-rich Western diet with beverages. The first profile leans heavily towards fruits, vegetables, and plant proteins like tofu and nuts. The salty Western diet with alcohol includes more meat and beverages such as beer and wine. The third profile is rich in pasta, pizza, desserts, and sugary carbonated drinks. The study took age, ethnicity, education, family history, and date of last prostate cancer screening into account. Marie-Elise Parent and Karine Trudeau found a link between a healthy diet and a lower risk of prostate cancer. Conversely, a Western diet with sweets and beverages was associated with a higher risk and seemed to be a factor in more aggressive forms of cancer. The study did not show any clear link between a Western diet with salt and alcohol and the risk of developing the disease. Moving away from the typical approach used in epidemiological studies, which involves looking at one nutrient or food group at a time, the researchers collected data from a broader dietary profile. “It's not easy to isolate the effect of a single nutrient,” explained Ms. Trudeau. “For example, foods rich in vitamin C, such as citrus fruits, promote iron absorption. Calcium is often found in dairy products, which also contain vitamin D. Our more targeted approach takes this synergy into account to produce more meaningful results that public health authorities can use to formulate recommendations. Rather than counting on one miracle food, people should look at their overall diet.” “For a long time we've suspected that diet might play a role in the development of prostate cancer, but it was very hard to pinpoint the specific factors at play,” said Professor Parent. “This study is significant because it looks at dietary habits as a whole. We've uncovered evidence that, we hope, can be used to develop prevention strategies for prostate cancer, the most common cancer among men in Canadaand many other countries.”   Compounds in 'monster' radish could help tame cardiovascular disease American Chemical Society, August 9, 2020 Step aside carrots, onions and broccoli. The newest heart-healthy vegetable could be a gigantic, record-setting radish. In a study appearing in ACS' Journal of Agricultural and Food Chemistry, scientists report that compounds found in the Sakurajima Daikon, or "monster," radish could help protect coronary blood vessels and potentially prevent heart disease and stroke. The finding could lead to the discovery of similar substances in other vegetables and perhaps lead to new drug treatments. Grown for centuries in Japan, the Sakurajima Daikon is one of the Earth's most massive vegetables. In 2003, the Guinness Book of World Records certified a Sakurajima weighing nearly 69 pounds as the world's heaviest radish. Radishes are good sources of antioxidants and reportedly can reduce high blood pressure and the threat of clots, a pair of risk factors for heart attack and stroke. But to date, no studies have directly compared the heart-health benefits of the Sakurajima Daikon to other radishes. To address this knowledge gap, Katsuko Kajiya and colleagues sought to find out what effects this radish would have on nitric oxide production, a key regulator of coronary blood vessel function, and to determine its underlying mechanisms. The researchers exposed human and pig vascular endothelial cells to extracts from Sakurajima Daikon and smaller radishes. Using fluorescence microscopy and other analytical techniques, the research team found the Sakurajima Daikon radish induced more nitric oxide production in these vascular cells than a smaller Japanese radish. They also identified trigonelline, a plant hormone, as the active component in Sakurajima Daikon that appears to promote a cascade of changes in coronary blood vessels resulting improved nitric oxide production.   Placebos prove powerful even when people know they're taking one Michigan State University, August 7, 2020   How much of a treatment is mind over matter? It is well documented that people often feel better after taking a treatment without active ingredients simply because they believe it's real -- known as the placebo effect. A team of researchers from Michigan State University, University of Michigan and Dartmouth College is the first to demonstrate that placebos reduce brain markers of emotional distress even when people know they are taking one. Now, evidence shows that even if people are aware that their treatment is not "real" -- known as nondeceptive placebos -- believing that it can heal can lead to changes in how the brain reacts to emotional information. "Just think: What if someone took a side-effect free sugar pill twice a day after going through a short convincing video on the power of placebos and experienced reduced stress as a result?", said Darwin Guevarra, MSU postdoctoral fellow and the study's lead author. "These results raise that possibility." The new findings, published in the most recent edition of the journal Nature Communications, tested how effective nondeceptive placebos -- or, when a person knows they are receiving a placebo -- are for reducing emotional brain activity.  "Placebos are all about 'mind over matter," said Jason Moser, co-author of the study and professor of psychology at MSU. "Nondeceptive placebos were born so that you could possibly use them in routine practice. So rather than prescribing a host of medications to help a patient, you could give them a placebo, tell them it can help them and chances are -- if they believe it can, then it will." To test nondeceptive placebos, the researchers showed two separate groups of people a series of emotional images across two experiments. The nondeceptive placebo group members read about placebo effects and were asked to inhale a saline solution nasal spray. They were told that the nasal spray was a placebo that contained no active ingredients but would help reduce their negative feelings if they believed it would. The comparison control group members also inhaled the same saline solution spray, but were told that the spray improved the clarity of the physiological readings the researchers were recording. The first experiment found that the nondeceptive placebos reduced participants' self-reported emotional distress. Importantly, the second study showed that nondeceptive placebos reduced electrical brain activity reflecting how much distress someone feels to emotional events, and the reduction in emotional brain activity occurred within just a couple of seconds. "These findings provide initial support that nondeceptive placebos are not merely a product of response bias - telling the experimenter what they want to hear -- but represent genuine psychobiological effects," said Ethan Kross, co-author of the study and a professor of psychology and management at the University of Michigan.     Greater coffee intake associated with decreased depressive symptoms among older Japanese women Nakamura Gakuen University (Japan), August 5, 2020   According to news reporting originating from Fukuoka, Japan, by NewsRx correspondents, research stated, “Depression in elderly people is a major global concern around the world. Epidemiological evidence of the association of beverages with depressive symptoms has received research attention; however, epidemiological studies on the association of coffee and green tea consumption with depressive symptoms among the elderly population are limited.” Our news editors obtained a quote from the research from Nakamura Gakuen University, “The objective of this study is to cross-sectionally examine the association of depressive symptoms with the intake of coffee, green tea, and caffeine and to verify the antidepressant effect of caffeine. The subjects were 1,992 women aged 65-94 years. Intakes of coffee, green tea, and caffeine, as well as depressive symptoms, were assessed with a validated brief dietary history questionnaire (BDHQ) and the Center for Epidemiologic Studies Depression Scale (CES-D), respectively. Multiple logistic regression analysis was used to calculate odds ratios (ORs) and 95% confidence intervals (as) for depressive symptoms with adjustments for potential confounders. Coffee intake was associated with a lower prevalence of depressive symptoms, the ORs of which for the 4th versus the 1st quartiles of intake was 0.64 (95% CI, 0.46-0.88, P for trend = 0.01) in a fully adjusted model. Caffeine intake was marginally associated with depressive symptoms, but the association was not statistically significant (OR 0.75; 95% CL 0,55-1,02. P for trend = 0.058). The result suggests that the inverse association of coffee intake with depressive symptoms might be associated with not only caffeine intake but also some other substances in coffee or factors related to coffee intake.” According to the news editors, the research concluded: “Because of the cross-sectional design of the present study, longitudinal studies are required to confirm the present finding.”     Sugary drinks and disease: Chugging 2 sodas per day increases your risk of premature death University College Dublin (Ireland), August 8, 2020   On top of raising blood sugar and contributing to abdominal fat, European researchers found that soda can also lead to an earlier death. Published in JAMA Internal Medicine, the study demonstrates that daily consumption of two or more sodas – diet or not – and other sweetened drinks corresponds to a 17 percent increase in the risk of premature death from all causes. The “bitter truth” of soda consumption: premature death To examine the relationship between soda consumption and the risk of all-cause and cause-specific mortality, the researchers studied 451,743 individuals living in 10 European countries, including Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden and the United Kingdom. The participants were from the European Prospective Investigation into Cancer and Nutrition (EIPC) study, one of the largest ongoing cohort studies on diet and its relation to cancer and other chronic diseases. None of the participants have any chronic conditions. The team studied their soda consumption for an average of 16 years. During that period, a total of 41,693 participants died from all causes, eleven percent of whom reported drinking at least two sodas daily, while nine percent reported drinking not more than one per month. The participants who drank two or more glasses of soda also had a higher risk of death from heart conditions. Meanwhile, those who reported consuming other beverages sweetened with either sugar or artificial sweeteners had a greater risk of death from digestive diseases. Participants who drank diet soda weren't off the hook either. The team reported that those who drank diet sodas also had a greater risk of earlier death from cardiovascular disease(CVD). Taken together, these findings indicate that the consumption of soda, diet soda and other sweetened beverages is linked to premature death from all causes, including CVD and digestive diseases. The researchers noted that their study supports public health campaigns aimed at limiting the consumption of sodas and other sugar-laden drinks.       Fisetin derivative shows promise against Alzheimer disease in mice Salk Institute, August 5 2020.    he September 2020 issue of Redox Biology published the finding of Salk Institute researchers of an ability for a compound derived from fisetin, a flavonoid occurring in many plants, to reverse memory loss in a mouse model of Alzheimer disease. The compound, known as CMS121, which was synthesized by Pamela Maher and colleagues, was recently demonstrated to slow brain cell aging. "This was a more rigorous test of how well this compound would work in a therapeutic setting than our previous studies on it," commented Dr Maher. "Based on the success of this study, we're now beginning to pursue clinical trials." In the current research, normal mice and mice that were genetically modified to develop Alzheimer disease were given CMS121 starting at nine months of age. Untreated Alzheimer mice and normal mice served as controls. At 12 months, memory and behavior tests revealed that treated Alzheimer mice performed as well as control mice and that Alzheimer mice that did not receive CMS121 performed worse.  An increase in lipid peroxidation was observed in brains cells of untreated Alzheimer mice in comparison with Alzheimer mice that received CMS121. "That not only confirmed that lipid peroxidation is altered in Alzheimer's, but that this drug is actually normalizing those changes," remarked first author Gamze Ates.  It was further determined that CMS121 lowered levels of the lipid-producing molecule fatty acid synthetase (FASN). Brain samples from human Alzheimer patients revealed that greater amounts of FASN were present in comparison with cognitively healthy patients, suggesting that FASN could be a drug target for Alzheimer disease.  "There has been a big struggle in the field right now to find targets to go after," Dr Maher stated. "So, identifying a new target in an unbiased way like this is really exciting and opens lots of doors."     REM sleep tunes eating behavior University of Bern (Germany),  August 7, 2020   Despite our broad understanding of the different brain regions activated during rapid-eye-movement sleep, little is known about what this activity serves for. Researchers at the University of Bern and the Inselspital have now discovered that the activation of neurons in the hypothalamus during REM sleep regulates eating behaviour: suppressing this activity in mice decreases appetite. While we are asleep, we transition between different phases of sleep each of which may contribute differently to us feeling rested. During (rapid eye movement) REM sleep, a peculiar sleep stage also called paradoxical sleep during which most dreaming occurs, specific brain circuits show very high electrical activity, yet the function of this sleep-specific activity remains unclear.  Among the brain regions that show strong activation during REM sleep are areas that regulate memory functions or emotion, for instance. The lateral hypothalamus, a tiny, evolutionarily well conserved brain structure in all mammals also shows high activity during REM sleep. In the awake animals, neurons from this brain region orchestrate appetite and the consumption of food and they are involved in the regulation of motivated behaviours and addiction. In a new study, researchers headed by Prof. Dr. Antoine Adamantidis at the University of Bern set out to investigate the function of the activity of hypothalamic neurons in mice during REM sleep. They aimed at better understanding how neural activation during REM sleep influences our day-to-day behaviour. They discovered that suppressing the activity of these neurons decreases the amount of food the mice consume. "This suggests that REM sleep is necessary to stabilize food intake", says Adamantidis. The results of this study have been published in the journal Proceedings of the National Academy of Sciences (PNAS). Long-lasting effect on neuronal activity and feeding behavior The researcher discovered that specific activity patterns of neurons in the lateral hypothalamus that usually signal eating in the awake mouse are also present when the animals were in the stage of REM sleep. To assess the importance of these activity patterns during REM sleep the research group used a technique called optogenetics, with which they used light pulses to precisely shut down the activity of hypothalamic neurons during REM sleep. As a result, the researchers found that the activity patterns for eating were modified and that the animals consumed less food. "We were surprised how strongly and persistently our intervention affected the neural activity in the lateral hypothalamus and the behaviour of the mice", says Lukas Oesch, the first author of the study. He adds: "The modification in the activity patterns was still measurable after four days of regular sleep." These findings suggest that electrical activity in hypothalamic circuits during REM sleep are highly plastic and essential to maintain a stable feeding behaviour in mammals.  It is a question of quality These findings point out that sleep quantity alone is not solely required for our well-being, but that sleep quality plays a major role in particular to maintain appropriate eating behaviour. "This is of particular relevance in our society where not only sleep quantity decreases but where sleep quality is dramatically affected by shift work, late night screen exposure or social jet-lag in adolescents", explains Adamantidis. The discovered link between the activity of the neurons during REM sleep and eating behaviour may help developing new therapeutical approaches to treat eating disorders. It might also be relevant for motivation and addiction. "However, this relationship might depend on the precise circuitry, the sleep stage and other factors yet to be uncovered", adds Adamantidis.   The key role of zinc in elderly immunity Federal University of Juiz de Fora (Brazil), August 7, 2020   According to news reporting originating from Juiz de Fora, Brazil, by NewsRx editors, the research stated, “The COVID-19 infection can lead to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mainly affecting patients aged 60 and older. Preliminary data suggest that the nutritional status can change the course of the infection, and on the matter, zinc is crucial for growth, development, and the maintenance of immune function.” Our news editors obtained a quote from the research from the Federal University of Juiz de Fora, “In the absence of treatment for this virus, there is an urgent need to find alternative methods that can contribute to control of disease. The aim of this paper is to establish the relation between zinc and COVID-19. From the prior scientific knowledge, we have performed a review of the literature and examine the role of zinc in immune function in the infection by COVID-19. Our findings are that the zinc as an anti-inflammatory agent may help to optimize immune function and reduce the risk of infection.” According to the news editors, the research concluded: “Zinc supplementation can be a useful strategy to reduce the global burden of infection in the elderly, there is a need the increased reporting to improve our understanding of COVID-19 and the care of affected patients.”    

This week on UnDiscipined, we're talking about extending life — how nature does it and how humans might do it. Grace DiRenzo investigates the way animals evolve to beat deadly natural chemicals. Laura Niedernhofer studies natural chemicals that might help us prevent aging and put off death. Together, we'll talk about Fisetin, frogs, fungus, zombies and immortality.