Podcasts about s0092

This episode covers:An interview with Dr. Jeff Gladden who shares valuable information on how you can improve both the quality AND quantity of your yearsLinks I mentioned during this episode:Join Revitalize: https://www.thelyonsshare.org/revitalizeGladden Longevity: https://www.gladdenlongevity.com/Living Beyond 120 podcast: https://livingbeyond120.com/podcastHow to improve sleep naturally: https://www.thelyonsshare.org/2018/10/09/how-to-improve-sleep-naturally/Megan's experience (and lessons) from blood sugar tracking: https://www.thelyonsshare.org/2021/03/01/how-to-keep-your-blood-sugar-stable-what-i-learned-from-wearing-a-continuous-glucose-monitor/Top metrics to track for your health: https://www.thelyonsshare.org/2020/12/14/top-metrics-to-track-for-your-health/How stress is impacting your health & life: https://www.thelyonsshare.org/2018/10/23/how-stress-is-impacting-your-life-health/ 2013 Cell longevity study: https://www.cell.com/fulltext/S0092-8674(13)00645-4How to take action after listening to this episode:Make the commitment to yourself that you will do your best for your health TODAY! 

Tucker Goodrich is a technology executive in the financial industry who designs, runs, and debugs complex systems in high-risk environments. Areas of expertise include risk management, systems management, and cyber-security. After experiencing some personal health crises and realizing that the ‘solutions' offered by medical professionals weren't working or addressing causation he started applying the same approach in research and evaluation of data to his own health issues to determine root causes. His interests have focused on dietary and environmental drivers of chronic disease, including carbohydrate, wheat, and various classes of fats. Specifically, he's attempting to understand and popularize understanding of the mechanisms driving the diet-derived explosion in so-called chronic diseases (or diseases of civilization). He is active on twitter (@tuckergoodrich, has a blog called Yelling Stop, is an Expert Advisor for the nutrition start-up Nutrita, and has been a guest on numerous podcasts.   Time Stamps: 0:10:16 Podcast begins 0:12:16 Tucker's blog post: https://yelling-stop.blogspot.com/2021/06/thoughts-on-of-rats-and-sidney-diet.html 0:14:16 Compounds that reduce overeating 0:17:16 Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity: https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2012.38 0:23:31 Endocannabinoid signal in the gut controls dietary fat intake: https://www.pnas.org/content/108/31/12904 0:29:56 A Neural Circuit for Gut-Induced Reward: https://www.cell.com/cell/fulltext/S0092-8674(18)31110-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418311103%3Fshowall%3Dtrue 0:35:46 CRP is a marker of oxidized linoleic acid 0:38:32 Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials: https://pubs.rsc.org/en/content/articlelanding/2017/FO/C7FO00433H 0:43:06 Take a pill or just stop eating so many seed oils? 0:45:16 Low‐Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events: https://www.ahajournals.org/doi/10.1161/JAHA.119.016318 0:49:46 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans: https://pubmed.ncbi.nlm.nih.gov/9844997/ 0:54:16 HNE - what is it and why is it important? 0:58:36 Where is linoleic acid even found? 1:02:46 The average amount of linoleic acid in the human diet 1:12:06 Why I don't eat bacon 1:14:46 Just because a study was conducted a long time ago, doesn't mean it should be ruled out 1:20:31 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73): https://www.bmj.com/content/353/bmj.i1246 1:27:16 When low LDL can result in a higher risk of cardiovascular disease 1:28:31 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis: https://www.bmj.com/content/346/bmj.e8707 1:32:16 Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study: https://pubmed.ncbi.nlm.nih.gov/9989963/ 1:40:40 The blood test you should consider getting  1:42:55 The idea of "intralipid" 1:51:00 Tucker's personal experience with weight loss and dietary changes 2:03:10 Health Characteristics of the Wayuu Indigenous People: https://academic.oup.com/milmed/article/184/7-8/e371/5481850 2:07:25 Where to find more of Tucker Goodrich   Sponsors: Blazing Bull: $150 off of a 1500 degree grill at BlazingBullGrills.com with code “CARNIVOREMD” at checkout Lets Get Checked: 20% off your order at www.TRYLGC.com/carnivoremd  White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order Belcampo: www.belcampo.com use code: CarnivoreMD for 20% off your order

This episode covers:A study about a class of food you can eat to strengthen your immune system and reduce inflammationA product recommendation for a snack that falls into the class of food mentioned aboveAll about how to choose healthy snacksTwo Q and As on how to increase iron without having digestive side effects and half & halfLinks I mentioned during this episode:Study on fermented and high-fiber foods and microbiome: https://www.cell.com/cell/fulltext/S0092-8674(21)00754-6Article on above study: https://www.sciencedaily.com/releases/2021/07/210712122151.htmProbiotics blog post: https://www.thelyonsshare.org/2021/01/24/probiotics-vs-prebiotics-whats-the-difference-and-do-i-need-to-take-both/Wildbrine Kimchi: https://wildbrine.com/product/mild-kimchi-with-turmeric/20 Healthy Snacks blog post: https://www.thelyonsshare.org/2019/04/09/20-healthy-snack-ideas/Slow release iron: https://amzn.to/3idomEqBeef liver capsules:  https://amzn.to/36xbrbg25% discount to Thrive Market: http://thrv.me/lyonsshare How to take action after listening to this episode:Consider your snack behavior. Do you think you're snacking appropriately for your goals? Are the snacks that you eat regularly balanced? If not, try to swap in one of the 20 that I mentioned today!

特記すべきことはありません。Show notes 碇ゲンドウ … 新世紀エヴァンゲリオンの登場人物。特務機関NERV最高司令官。主人公のお父さん。 冬月コウゾウ … 新世紀エヴァンゲリオンの登場人物。特務機関NERV副司令官。 形而上生物学第1研究室 … 冬月の大学時代のラボ 白眉プロジェクト 新学術領域研究 冥王代 冥王代生物学の創生 … 話の流れから冥王代を茶化した様になってしまいましたが、決してそんなことはありませんのでご容赦ください。 SDGs … Sustainable Development Goalsの略。日本語だと持続可能な開発目標。関連する外務省のページ シンギュラリティ … 人工知能がすごいことになるアレ。日本語だと技術的特異点、かっこいい。 テンセグリティ ムーンショット型研究開発制度 ケンタロスアルファショット … 月よりも遠いどこか スプツニ子！ アンドロメダ … 前衛武装宇宙艦 惣流・アスカ・ラングレー … 式波・アスカ・ラングレーもいる 円城塔 文字禍 薄っぺらな嘘 … 「ドッキリテクスチャー」とルビが振られる。HUNTER X HUNTERに登場するヒソカの能力。 冨樫義博 荒木飛呂彦先生が表紙を飾ったCELL … Cell, Sep 07, 2007 荒巻大輔 … 攻殻機動隊に登場する内務省公安9課の部長 攻殻機動隊 るろうに剣心 … 続編の北海道編がジャンプSQで連載中！ 1/3の純情な感情 … SIAM SHADEによる、るろうに剣心のエンディングテーマ シティハンター 冴羽獠 … シティハンターの主人公 キッズステーション Get wild … TM NETWORKによるシティハンターのエンディングテーマ 海藤優 … 幽遊白書の登場キャラクター。読みは「かいとうゆう」。 幽★遊★白書 ポロロッカ … 「アマゾ…」。上記海藤のゲームマスター戦における名シーン。元ネタはこちら Zettelkasten … ノートテイキングの手法。Ep66. Weaving a web of ideasでも取り上げさせていただきました。 則巻千兵衛 … Dr.スランプの登場人物。 天才バカボン クレヨンしんちゃん 北斗の拳 あしたのジョー 矢吹丈 … あしたのジョーの主人公 GS美神 極楽大作戦!! 横島忠夫 … GS美神 極楽大作戦!!の登場人物。 ルパン３世 花の慶次 ―雲のかなたに― サンクチュアリ 島耕作 騎士団長 島耕作 騎士団長殺し アカギ－闇に降り立った天才 銀と金 オールラウンダー廻 ホーリーランド ヒカルの碁 六三四の剣 おれは鉄平 カムイ伝 サスケ … カムイ伝、あしたのジョー、鉄平、サスケ、ドカベンが小学生時代のtadasuのバイブル ワタリ 忍者武芸帖 ブラック・ジャック ブッダ 火の鳥 医龍 愛と幻想のファシズム ああ播磨灘 大谷翔平 … 怪物大谷翔平。今年のフェンウェイパークの値段にチビっていかなかったことを後悔。二年前の観戦記はこちらep23。 ONE OUTS ROOKIES SLAM DUNK duolingo 竜馬がゆく マシュー・メセルソン トニー・スターク … アイアンマンの中の人 イーロン・マスク グリゴリー・ペレルマン h-index nature metaphysical biology すべてがFになる 犀川創平 … すべてがFになるの主人公 ドグラ・マグラ Editorial notes (soh) metaphysical biologyについてはいずれ。(tadasu) 軽いジャブのつもりが一本撮れました(coela)

En este episodio, nos alarmamos (no tanto) con la noticia de los embriones mezcla de macaco y humano, nos pusimos nostálgicos pensando en los microbios del aire de nuestros parques favoritos y, de la mano de nuestro invitado David Diez del Molino, nos sorprendimos con el hallazgo de ADN milenario de mamuts en Siberia y con cómo este cambia la lo que sabemos sobre la historia evolutiva de estos animales. Menú 00:20 - Saludos y presentaciones 04:49 - Embriones quimera de macaco y humano 24:04 - Bacterias en el aire de los parques 44:28 - ADN antiguo de mamuts mil milenarios 01:17:13 - BONUS – Nuestro invitado de cerca Invitado: David Diez del Molino Voces y contenido: David Diez, Sofía Flores, Rodrigo Pacheco y Víctor Hernández Producción: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Edición: Víctor Hernández Voz en la rúbrica: Valeria Sánchez Este podcast es producido desde un lugar de la Ciudad de México en el que la quimera más famosa es la rata-paloma y el aire de las áreas verdes llega hasta el sexto piso. Fuentes y lecturas recomendadas El artículo original de los embriones quiméricos de macaco y humano: https://www.cell.com/cell/fulltext/S0092-8674(21)00305-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421003056%3Fshowall%3Dtrue Cobertura en español, con entrevista a uno de los investigadores: https://elpais.com/ciencia/2021-04-15/cientificos-espanoles-crean-en-china-132-embriones-con-mezcla-de-mono-y-humano.html Y un ensayo sobre experimentos similares: https://www.revistadelauniversidad.mx/articles/673da0d9-da70-446d-8b57-33e191b2124e/el-experimento-humano El estudio de las bacterias en el aire de las áreas verdes: https://www.nature.com/articles/s41598-021-89065-y Un ensayo de los mismos investigadores, pero en tono no especializado (sin embargo, en inglés): https://theconversation.com/how-the-trees-in-your-local-park-help-protect-you-from-disease-160312 Y el resumen de uno de sus artículos traducido al español: https://ciudadesverdes.com/download/estratificacion-vertical-en-aerobiomas-de-areas-verdes-urbanas/ El artículo original de David y sus colegas: https://www.nature.com/articles/s41586-021-03224-9 Cobertura en español, con entrevista a David: https://www.agenciasinc.es/Noticias/EL-ADN-mas-antiguo-jamas-secuenciado-revela-un-nuevo-linaje-de-mamuts Sobre el bucardo de los pirineos: https://invdes.com.mx/ciencia-ms/bucardo-fue-primer-animal-extinto-ha-resucitado-cientifica-britanica/ Música y audios Intro y salida: Little Lily Swing, de Tri-Tachyon, bajo una licencia Creative Commons 3.0 de Atribución: freemusicarchive.org/music/Tri-Tachyon/ Sección personal: The Zeppelin de Blue Dot Sessions bajo licencia tipo Attribution-NonCommercial License.  Rúbrica: Now son, de Podington Bear, freemusicarchive.org/music/Podington_Bear/ Bajo una licencia Creative Commons Internacional de Atribución No Comercial 3.0 “Quimera”, del querido Jorge Drexler: https://www.youtube.com/watch?v=VJUBMbUSxjg “Glass in the Park”, de Alex Turner: https://www.youtube.com/watch?app=desktop&v=_ck-k1vvpLE Comercial del Mamut de los años 80 (congelado sí sabía mejor, la verdad): https://www.youtube.com/watch?v=U-SnSzXt9yc

FM脑科学新闻 | 适应新环境的神经基础是什么？前额叶Gamma波有重要作用。电极假体可以给失明患者带来光明吗？ 导读：无信号仪器 皮皮佳责编：Zhu Xiao配音：行者背景音乐：lovely piano song-Guru排版：KinoNature Neuroscience | 前额叶PV神经元间跨半脑的Gamma同步波支持规则转换学习中的行为调整生物体在适应变化的环境时，经常会遇到已有的行为策略不再有效的情况，因此它们需要及时停止无效的策略并学习新的策略。在精神分裂症中，这种能力的缺失标志着前额叶功能紊乱，而特殊神经元之间的同步活动则可以使大脑进入一种有活力的状态，并促进行为策略的调整。Vikaas Sohal教授的团队近期发现，在规则转换学习（rule shift learning）中，在左右半球的内侧前额叶皮质（medial prefrontal cortex, mPFC）里的小清蛋白中间神经元（parvalbumin interneuron）会产生Gamma同步波（频率约30-80Hz）来支持行为调整。该团队设计了巧妙的行为学实验来令小鼠学习“规则转换”，他们先让小鼠在训练中学会将特定的气味与埋在培养基里的食物奖励关联，再把获取奖励的规则改为识别特定的培养基质地，最后观察小鼠在规则转换后的表现，测试小鼠学习新规则的能力。他们发现小清蛋白中间神经元之间的跨半球Gamma同步活动会在小鼠发现旧规则不适用时增强，而当他们用光遗传学手段扰乱Gamma同步后，小鼠便难以学会新规则。因此，他们认为Gamma同步对重新评价外部线索的行为学意义是必不可少的。（导读：无信号仪器） 文章链接：https://www.nature.com/articles/s41593-020-0647-1图片来源：https://www.dreamstime.com/closeup-small-vole-mouse-digs-hole-near-grains-rye-field-closeup-small-vole-mouse-digs-hole-near-grains-rye-image102969982 Cell | 定向激活特定的位置细胞能改变小鼠的行为认知地图（Cognitive map）一直都是海马领域的研究热点，发表在《Cell》上的一篇工作首次通过活体钙成像和单细胞光遗传技术，证实激活特定的位置细胞，能让小鼠产生记忆引导的空间行为变化。作者首先将带有荧光蛋白的病毒注射在小鼠右侧海马区，随后让小鼠在一个虚拟的跑道中探索。跑道分为开始区域（start zone)和奖赏区域（reward zone），作者发现，激活开始区域的位置细胞，能让小鼠出现超速跑的行为，而激活奖赏区域的位置细胞，小鼠则会提前终止任务。此外，这一过程是由位置细胞网络去调节的。这项工作第一次在功能学层面证实了认知地图存在的重要性，为日后的研究带来了新的思路。（导读：皮皮佳） 原文地址：https://www.cell.com/cell/pdf/S0092-8674(20)31302-7.pdf图片地址：https://in.pinterest.com/pin/335518240971381405/ Science | 视皮层上的电极假体有望治疗失明 失明影响着全世界四千万人的生活，但是这一疾病目前尚未有明确的治疗手段。于是科学家就想：能在他们的脑内植入神经假体，实现重建功能学视觉的效果嘛？之前有研究将电极放在大脑表面，并施以高电流刺激，结果发现不仅同时能被刺激的电极数目有限，而且电极会激活很区域，空间分辨率低。近期《Science》上的一篇研究，解决了低空间分辨率的问题。他们在猴子V1和V4这两块视皮层植入了有1024个通道的神经假体，并对视皮层进行了电刺激，发现猴子对电极产生的光点幻觉（phosphenes）与被刺激的神经元的实际感受野相匹配。其中，V4的活动成功预测了将在V1产生的光幻觉。他们同时刺激了多个电极，来产生一些视觉图案（如简单的形状、运动或字母），发现猴子能立刻识别出这些图案。这项研究证实了电刺激具有重建功能性视觉的可能性。（导读：皮皮佳） 原文链接：http://science.sciencemag.org/content/370/6521/1191图片链接：https://kyeye.com/near-or-far-what-does-20-40-vision-mean/ Nature Neuroscience | 前额叶皮层中星形胶质细胞的GABA能信号能维持目标定向行为 星形胶质细胞会与全脑的突触相互作用，并被认作是兴奋性突触传递的调控性元件。但是，关于GABA能中间神经元与星形胶质细胞之间的相互作用对行为的影响，一直都不是很清楚。发表在《Nature Neuroscience》上的一篇文章发现，对内前额叶皮层的星形胶质细胞内的GABAB型受体进行敲除后，改变了low-gamma震荡和皮层神经元的放电特性，最终影响了目标定向性行为。值得一提的是，工作记忆受损是可以通过光遗传激活星形胶质细胞被重建的。此外，研究人员发现，在野生型小鼠内，通过视黑素激活星形胶质细胞，能够提高皮层神经元的放电速率和Gama震荡，并且对认知功能也有促进作用。该工作鉴定了星形胶质细胞是一个控制皮层环路的抑制性中心，为皮层信息处理和目标定向性运动提供了一个全新的通路解释。（导读：皮皮佳） 原文链接：https://www.nature.com/articles/s41593-020-00752-x图片链接：https://brainxell.com/cortical-gabaergic-neurons Neuron | 初级视皮层的去抑制通路 在日常生活中，情境（context）通过影响刺激的显著性来指导我们的感知觉。同样，在视皮层中，神经元对一个特定刺激的响应也受到视觉情境的调节。不过，这背后的机制一直都未被揭示。发表在《Neuron》上的一篇文章通过利用光学记录、操纵和计算建模等方法，发现由表达血管活性肠肽（VIP）和表达生长激素抑制素（SOM）的神经元组成的去抑制通路，能够调节小鼠视皮层的神经元应答，并且这种应答依赖于视觉刺激与刺激周边的差异性。当一个刺激与刺激周边很相似，那么VIP神经元就处于失活的状态，同时SOM神经元会抑制兴奋性神经元的活性。但当刺激与刺激周边差异显著时，VIP神经元就会变得十分活跃，抑制SOM神经元，从而解除其对兴奋行神经元的抑制。该研究为视皮层神经元活性的调节带来了新的思路。（导读：皮皮佳） 原文链接：https://www.sciencedirect.com/science/article/abs/pii/S0896627320308916?dgcid=rss_sd_all图片链接：https://guardian.ng/guardian-woman/everything-begins-with-a-vision/ Current Biology | 幼鱼利用嗅觉躲避盐水 盐度限制了所有水生生物的栖息环境，幼年斑马鱼也不例外。作为地道的淡水鱼，它们无法在高盐环境中生存。因此，研究人员就推测它们的脑内可能存在某些依赖于盐度定位的神经环路。考虑到斑马鱼没有表皮钠离子通道，故它们可能采取了一种人类未知的探测盐分的机制。在该篇研究中，研究人员利用钙成像技术找到了探测盐分的主要嗅觉系统，并明确了一群编码绝对盐度的嗅觉受体神经元。这项工作首次提出幼年斑马鱼拥有嗅觉导航能力，为嗅觉相关的研究带来了新思路。（导读：皮皮佳）原文链接：https://www.sciencedirect.com/science/article/pii/S0960982220317644图片链接：https://www.foodnavigator.com/Article/2014/11/25/Quiet-salt-reduction-is-vital-but-gourmet-salt-growth-may-stifle-industry-efforts

Dr. Lexi Walls is a biochemist, not a prophet—though, admittedly, it can sometimes be hard to tell the difference.Six years ago, when Lexi started researching coronaviruses, they were an understudied and poorly understood class of viruses. When Lexi wrote about the “tremendous pandemic potential of coronaviruses” in December 2019, no one realized that the seeds of the COVID-19 pandemic had already been sown. When Lexi completed her doctoral dissertation that same month on the structure of coronavirus spike proteins, she couldn’t have imagined how large those spike proteins soon would loom in our public consciousness, and in our efforts to develop effective vaccines against COVID-19.In this episode, Lexi joins Jocelyn and Bradley to share the surreal experience of doing “basic” research that turned out to have swift, profound, and far-reaching applications. She explains how the use of cryo-electron microscopy enabled her to characterize the structure of coronavirus spike proteins in great detail, and why this is so important for understanding how these viruses infect cells, how our immune system recognizes and responds to them, and how the emergence of variants could affect the course of the pandemic. She also explains the differences between mRNA vaccines and vector vaccines, as well as how these compare to more traditional types of vaccines. Finally, Lexi shares exciting news about a COVID vaccine she and her colleagues have developed using synthetic protein nanocages (!), and the friends discuss the future of pan-virus vaccines that might make us better prepared for the next pandemic.Follow Lexi on Twitter @coronalexington, and learn more about her amazing work at the links below!https://www.grad.uw.edu/lexi-walls/https://scienceinseattle.com/2020/03/18/dr-lexi-walls-talks-coronaviruses-and-cryo-em/https://youtu.be/e1YEyPX-PqwThe Veesler Lab:https://faculty.washington.edu/dveesler/https://twitter.com/veeslerlabDesigned Protein Nanoparticle Vaccine:https://www.cell.com/cell/fulltext/S0092-8674(20)31450-1Further Reading:“Multitude of coronavirus variants found in the US — but the threat is unclear” (Ewen Callaway, Nature): https://www.nature.com/articles/d41586-021-00564-4“What Do Vaccine Efficacy Numbers Actually Mean?” (Carl Zimmer and Keith Collins, The New York Times): https://www.nytimes.com/interactive/2021/03/03/science/vaccine-efficacy-coronavirus.html“Here’s Why Johnson & Johnson’s Vaccine Only Requires One Dose” (Emily Mullin, Medium): https://coronavirus.medium.com/how-does-johnson-johnsons-vaccine-work-a17524d85edd“Variant-proof vaccines — invest now for the next pandemic” (Dennis R. Burton and Eric J. Topol, Nature): https://www.nature.com/articles/d41586-021-00340-4“Self-assembly: From Nanowaffles to Nanostructures!”: https://funsizephysics.com/from-nanowaffles-to-nanostructures/ “Forming Nanostructures: Froot Loops, Legos, and Self-assembly”: https://funsizephysics.com/froot-loops-legos-self-assembly/Related episodes:What’s so “basic” about basic research? (Discussion): https://podcasts.apple.com/us/podcast/12-discussion-whats-so-basic-about-basic-research/id1471423633?i=1000448570255Everyone Has Herpes (Lisa Poppe): https://podcasts.apple.com/us/podcast/8-lisa-poppe-everyone-has-herpes/id1471423633?i=1000446370166Pandemic: A Letter from the Past (Gregg Mitman): https://podcasts.apple.com/us/podcast/40-gregg-mitman-pandemic-a-letter-from-the-past/id1471423633?i=1000470227078Beyond Bat Soup (Dorothy Tovar): https://podcasts.apple.com/us/podcast/44-dorothy-tovar-beyond-bat-soup/id1471423633?i=1000473039535Hindsight --> Insight --> Foresight (Nidhi Gupta): https://podcasts.apple.com/us/podcast/74-nidhi-gupta-hindsight-insight-foresight/id1471423633?i=1000505283002Big Little Life (Hannah Gavin): https://podcasts.apple.com/us/podcast/78-hannah-gavin-big-little-life/id1471423633?i=1000510524624Go Small or Go Home! (Axel Enders): https://podcasts.apple.com/us/podcast/16-axel-enders-go-small-or-go-home/id1471423633?i=1000452081082

In this episode, Dr’s J and Santhosh discuss the surprising medical contributions from our caveman cousins. Along the way they cover the flintstones, medical etymology, viral history, caveman genes, ancient infections being unearthed, intro genetics, adaptive evolution, neanderthal skin types, HLA and TLR, denisovans, human sexual skill, herv-K and more! So sit back and relax as we teach you about genetic protectionsSources1) https://www.nature.com/articles/d41586-018-06004-02) https://www.nature.com/articles/s41586-020-2818-33) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23960/4)https://www.sciencealert.com/neanderthal-rna-virus-protein-genes-benefit-modern-humans5)https://www.weforum.org/agenda/2017/05/the-deadly-diseases-being-released-by-climate-change/ 6)https://www.cell.com/cell/pdf/S0092-8674(18)31095-X.pdfSupport Us spiritually, emotionally or financially here! Twitter: @doctorjcomedy @toshyfro Instagram: @travelmedicinepodcast Spotify: https://open.spotify.com/show/28uQe3cYGrTLhP6X0zyEhTFacebook: facebook.com/travelmedicinepodcast Squarespace: travelmedicinepodcast.squarespace.com Patreon: https://www.patreon.com/travelmedicinepodcast Gmail: travelmedicineinfo@gmail.com

T2E66 – Cables sensores de temblores, el fagoma intestinal e hipopótamos invasores En este episodio, nos interesamos por la posibilidad de detectar movimientos sísmicos por medio de los cables submarinos de una cierta compañía digital que empieza con “G” y acaba con “oogle”, nos asombramos de la diversidad de virus que infectan bacterias que habitan en nuestros intestinos y, de la mano de nuestra invitada Nataly Castelblanco, reflexionamos seriamente sobre cómo resolver el problema de los hipópotamos invasores en Colombia. Menú 00:19 – Saludos y presentaciones 02:32 – Detectar sismos por medio de los cables de internet submarinos 18:18 – Diversidad de virus en el intestino 36:37 – El caso de los hipopótamos invasores en Colombia y cómo resolverlo BONUS 01:14:12 – Nuestra invitada de cerca Invitada: Nataly Castelblanco Voces y contenido: Nataly Castelblanco, Sofía Flores, Rodrigo Pacheco y Víctor Hernández Producción: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Edición: Víctor Hernández Voz en la rúbrica: Valeria Sánchez Este podcast es producido desde un lugar de la Ciudad de México en el que sí tiembla, lo cual alborota las panzas con virus, pero no a los hipos invasores, pues no tenemos. Fuentes y lecturas recomendadas Cobertura del estudio de detección de sismos (en inglés): https://www.inverse.com/innovation/google-curie-subsea-cables-earthquake-detection Artículo original (en inglés): https://science.sciencemag.org/content/371/6532/931 Estudio original del fagoma intestinal: https://www.cell.com/cell/fulltext/S0092-8674(21)00072-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421000726%3Fshowall%3Dtrue Cobertura en español: https://www.abc.es/ciencia/abci-descubren-70000-virus-desconocidos-interior-intestino-humano-202102270204_noticia.html El estudio original de Nataly y sus colegas: https://www.sciencedirect.com/science/article/pii/S0006320720309812?dgcid=author Cobertura en español: https://www.ngenespanol.com/animales/expertos-advierten-que-la-esterilizacion-de-hipopotamos-en-colombia-no-sera-suficiente-para-detenerlos/ Música y audios Intro y salida: Little Lily Swing, de Tri-Tachyon, bajo una licencia Creative Commons 3.0 de Atribución: freemusicarchive.org/music/Tri-Tachyon/ Sección personal: The Zeppelin de Blue Dot Sessions bajo licencia tipo Attribution-NonCommercial License.  Rúbrica: Now son, de Podington Bear, freemusicarchive.org/music/Podington_Bear/ Bajo una licencia Creative Commons Internacional de Atribución No Comercial 3.0 Fragmento de cuando Homero consigue cable gratis: https://www.youtube.com/watch?v=tq9dE_eErHU&t=32s Video didáctico de Japón para aprender inglés: https://www.youtube.com/watch?v=CKjaFG4YN6g Comercial de los 90 del juego Hipos glotones: https://www.youtube.com/watch?v=sQCDjUUJnGo

Last episode we discussed the history of antibiotics and alluded to RESISTANCE, the ability of bacteria to adapt to antibiotics to the point where the drugs aren't effective anymore. This is a huge, global problem, one that requires changes in policy and individual behavior, but all that other stuff is for some other time -- we're going to talk about the science of antibiotic resistance and what sorts of things scientists are cooking up to try to fight back! This episode has features a promo for Sips, Suds, and Smokes, a podcast about whiskey, beer, and cigars! Check them out on twitter @sipssudssmokes! Email us at petridishpod -at- gmail.com. On twitter @dishpodcast and instagram @petridishpodcast. References: https://www.cdc.gov/drugresistance/solutions-initiative/index.html https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance https://www.cdc.gov/mmwr/volumes/69/wr/mm6924a2.htm?s_cid=mm6924a2_w https://www.pnas.org/content/118/5/e2016886118 https://www.frontiersin.org/articles/10.3389/fmicb.2018.02928/full https://www.cell.com/cell/pdf/S0092-8674(18)30162-4.pdf https://science.sciencemag.org/content/367/6474/200 https://pubmed.ncbi.nlm.nih.gov/18843302/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380099/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188119/ https://www.economist.com/graphic-detail/2018/04/02/antibiotic-use-is-rapidly-increasing-in-developing-countries https://www.sciencedirect.com/science/article/abs/pii/S0959652619322085 https://www.frontiersin.org/articles/10.3389/fmicb.2019.00633/full https://www.sciencedirect.com/science/article/pii/S0966842X1730210X https://www.nature.com/articles/s41599-018-0181-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573035/ https://www.pnas.org/content/113/51/14477 https://www.nature.com/articles/d41586-020-00018-3 https://www.nature.com/articles/s41586-019-1665-6

Our first episode ever was about the microbiome, all the little bacteria and fungi and other folks living on and inside of us. While maybe you might not have heard of the microbiome, you've probably heard of stuff that is *supposed* to help the microbiome -- things like prebiotics and probiotics, which are often advertised as good for your gut health. Is that real? What is the science there? This episode has a promo for Curiosity Cake, a podcast featuring laid back conversations with experts on to interesting topics! Check them out on twitter @curiosity_cake! Email us at petridishpod -at- gmail.com. On twitter @dishpodcast and instagram @petridishpodcast. References: https://www.nature.com/articles/s41467-020-19940-1 https://www.sciencedirect.com/science/article/abs/pii/S009286741931387X https://www.sciencedirect.com/science/article/pii/S0092867418311024 https://www.cell.com/cell/fulltext/S0092-8674(18)31108-5

Lucy Mailing, Ph.D. received her Bachelor’s in Biology from Kalamazoo College and her Ph.D. in Nutritional Sciences from the University of Illinois, where her dissertation research focused on the effects of diet and exercise on the gut microbiome in states of health and disease. Lucy has authored several peer-reviewed journal articles related to the microbiome and health and was named an Emerging Leader in Nutritional Sciences by the American Society for Nutrition in 2017. Lucy has also served as a staff research associate for the Kresser Institute for Functional and Evolutionary Medicine since 2015. Lucy is the founder and sole author of lucymailing.com, a site dedicated to evidence-based articles about the microbiome, gut and skin health, and nutrition. She is regularly invited to speak on gut health around the country and has been recognized as one of the most trusted experts in the integrative health space. Lucy plans to continue her academic training and begin a postdoc in 2020 after a gap year dedicated to writing and other projects.  Time Stamps:  0:08:47 Podcast begins 0:09:55 What is a healthy gut microbiome? 0:12:43 The Microbiome of the Hadza 0:14:25 Enterocyte-Associated Microbiome of the Hadza Hunter-Gatherers https://www.frontiersin.org/articles/10.3389/fmicb.2016.00865/full 0:18:36 Figure: Typical major phyla and genera of the human gut microbiome https://www.researchgate.net/figure/Typical-major-phyla-and-genera-of-the-human-gut-microbiome-reproduced-with-permission_fig1_331990159 0:22:05 Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania https://science.sciencemag.org/content/357/6353/802#:~:text=The%20data%20reveal%20annual%20cyclic,reappear%20in%20a%20subsequent%20season.&text=These%20data%20indicate%20that%20some,and%20abundance%20in%20modernized%20populations. 0:24:38 Pervasive bias in research 0:30:10 Gut microbiome of the Hadza hunter-gatherers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996546/ 0:31:11 Microbiological dark matter and the infancy of gut microbiology 0:38:17 The Story of Butyrate 0:42:19 Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines https://www.jci.org/articles/view/133371 0:44:04 Figure: Cartoon of the acylcarnitine shuttle and β-oxidation of fatty acids in mitochondria. https://www.researchgate.net/figure/Cartoon-of-the-acylcarnitine-shuttle-and-b-oxidation-of-fatty-acids-in-mitochondria_fig1_323380097 0:46:00 GUT MICROBIAL METABOLOME: REGULATION OF HOST METABOLISM BY SCFAs https://core.ac.uk/download/pdf/77011125.pdf 0:47:50 Fermentation of animal components in strict carnivores: A comparative study with cheetah fecal inoculum https://www.researchgate.net/publication/221789283_Fermentation_of_animal_components_in_strict_carnivores_A_comparative_study_with_cheetah_fecal_inoculum 0:52:50 Diet rapidly and reproducibly alters the human gut microbiome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957428/ 0:55:42 An Expanded Genetic Code Enables Trimethylamine Metabolism in Human Gut Bacteria https://msystems.asm.org/content/5/5/e00413-20/article-info 0:55:42 How animal-based diet's produce risk of cardiovascular disease 0:58:50 No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris https://www.sciencedirect.com/science/article/pii/S2666149720300025 1:00:27 L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women https://www.karger.com/Article/Abstract/495037 1:03:12 Ketogenic Diets > High Fiber Diets 1:03:12 Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells https://www.cell.com/cell/fulltext/S0092-8674(20)30490-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420304906%3Fshowall%3Dtrue 1:10:22 Effect of honey in improving the gut microbial balance https://watermark.silverchair.com/fyx015.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAp0wggKZBgkqhkiG9w0BBwagggKKMIIChgIBADCCAn8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMUBN9HS4m_4yDlucaAgEQgIICUNhQPQ_X2HqAJ4azqDCrr58lLQ6xyaJ7Zk2aKCN55b-zbRJDQkjuIRY0O6AWv46fMXyMjFRAxlfT2wsTeIp3Hl70aDMCoegqkEDxUHQeSKamahl3-4OkPR4l4PhZ011-brRqW4C2exEo-yeKe3T4ERvV3P4FzLoQsgsV_npm8Pb4r4rpdRmiHaTDi6u2Q7fftFH-NHjGQMq8xxV9LYTEKUo_IrCw7gpCcoyw5VoH9QYyGn6dbmbifNlJFqAW41KH-kP91swAZuZJXxJHiH1sqg8z1pfKpPZCUw6blJ5PR5NJBhgApe2CWe_lBC0wsjDNDVnqX-eMji3pS6midB1w4loUJVbOuGuya-BRaJK2UvtfNhzur4IVhgXmIygvGUAmBFdoMKaSJuflGTZTu5KknPLp-_sCSS-zQvDFjWCd_Fkv0PVQU21_WlltwPjR1JplprHEQm7PSXH0kX3K2zUSJ5dHITe_N8PkzeW1bCdxqrO2y5uuk4bXs8wVSrsr1yZze7QmxZpxIXwIRVGO-eJElM31V-5jL7TUnJP8AamI1niGI7mVTmmGbfdtMEaxdjmjaw1lIt05BhTxMZSCswDQRG9gCD5-dQkQ1p0oajFPn02-dvrB0QypF1kekU151KjrQxWdM4v-Yc3aZ12ZOr8Z2OlUIWLQ6lfPRNK2AqwgNGA_yzxUixsD0kjvvvy8ZD4KmVFypxkpLFrZ_tAeK78twOA6yqOUT3VfCm6XDeFZsq7LwUS94nC07VbrrEiePVBwkIcrNaa-KnSQolkEs4SnPyQ 1:12:37 Phenolics and Carbohydrates in Buckwheat Honey Regulate the Human Intestinal Microbiota https://www.hindawi.com/journals/ecam/2020/6432942/ 1:15:20 A deeper look at alpha diversity 1:19:11 Gut Microbiota-Targeted Diets Modulate Human Immune Status https://www.biorxiv.org/content/10.1101/2020.09.30.321448v1.full 1:20:51 The value of fermentation 1:27:16 Gut microbiome response to a modern Paleolithic diet in a Western lifestyle context https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687155/ 1:30:51 Sun exposure and alpha diversity 1:31:31 Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821880/ 1:33:17 How to remedy an urbanized microbiome 1:40:35 What nutrients build a healthy gut lining? 1:43:48 Carnivore MD's Diversity score 1:47:16 Lucy's backstory 1:54:32 Rehabilitating the microbiome 2:03:02 When to not follow a carnivore diet 2:06:44 The many ways of healing the gut 2:09:12 Where to find Lucy Mailing 2:09:52 Lucy Mailing radical independent research -- 30-day Animal-Based Reset: www.AnimalBased30.com  Heart & Soil: www.heartandsoil.co  White Oak Pastures: www.whiteoakpastures.com code CarnivoreMD for 10% off first order Belcampo: www.belcampo.com code CarnivoreMD for 20% off Let’s Get Checked:  www.trylgc.com/carnivoremd  Helix: www.helixsleep.com/carnivoremd

In der Nacht vor dem Heiligen Abend erscheint die Weihnachtsfolge mit Jasmin und Lorenz, yay! Zuerst geht Jasmin der Frage auf die Spur, wo der Weihnachtsmann eigentlich lebt. Wir schauen uns verschiedene Theorien unterschiedlicher Länder an, wandern mit Rentierherden durch Lappland und treffen Eisbären am Nordpolarkreis. Lorenz widmet sich dann der Biologie im Weltraum, zum Beispiel, wie sich das Leben auf Expeditionen ins All verändert, welche Gefahren für unsere Gesundheit da lauern und wie man versucht, diesen zu begegnen.. Außerdem lernt ihr, warum einige Kosmonauten so unglaublich dünne Beine bekamen. Abschließend widmen sich Jasmin und Lorenz der Frage nach ihren liebsten - jedoch unerfüllbaren - Wünschen für Geschenke zur Weihnacht und evaluieren ihr Lieblingsgebäck. Viel Spaß und frohe Weihnachten! ---------- Material Lappland: https://www.youtube.com/watch?v=Ndorb-tUESY Sammlung von Arbeiten zur Biologie im Weltraum vom Journal Cell: https://www.cell.com/c/the-biology-of-spaceflight Übersichtsarbeit zum Thema Veränderungen menschlichen Lebens auf Missionen im Weltall: https://www.cell.com/cell/fulltext/S0092-8674(20)31457-4 Die Zwillings-Studie der US-Weltraumbehörde: https://science.sciencemag.org/content/364/6436/eaau8650

バクテリアで35年前に発見されたレトロンと呼ばれる謎の因子の機能に大胆に迫った論文を読みました。Show notes Bacterial Retrons Function In Anti-Phage Defense. Millman et al Cell 2020…これが今回紹介するレトロンの論文です。 細菌の逆転写酵素およびmsDNAの構造と機能 (日本細菌学雑誌, pdf)…日本語で読めるレトロンの機能などに関する総説論文。 逆転写酵素 (Wikipedia) Genomically encoded analog memory with precise in vivo DNA writing in living cell populations. Science 2014…この論文で初めてレトロンの一部の領域が自在に改変でき、大腸菌の集団に外部刺激を記録するツールとして転用された。 Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing. Cell 2018…この論文ではレトロンを改造し、相同組み替えのドナーDNAをガイドRNAと同時に細胞へ導入する新しいゲノム編集法として転用された。 RNaseH (Wikipedia) 制限酵素についてはエピソード72で詳しく話しました。 ウイルスプラーク (Wikipedia) バクテリオファージT4とT7 Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies. Nature Methods…Anti-CRISPRタンパク質に関するレビュー論文。 フレームシフト変異 (Wikipedia) RecBCD (Wikipedia) Ediorial notes Defense islandで宝探しをしよう！ (soh) レトロンって名前がかっこいい。fugafuga-tronっていう名前に憧れる。イントロン、レトロン、ウルトロン(tadasu)

Join Jimmy Coconuts by a roaring fire for a very jolly Winter Solstice Holiday Season episode! Ol' Man Sean and Uncle Nathan discuss what sorts of genetic and physical modifications could result in your own werewolf, if you had access to slightly futuristic tech and a wobbly moral compass! This episode has a promo for Dear Grad Student, an interview podcast about grad school life, trials, and tribulations! Check them out on twitter @DearGradStudent! Email us at petridishpod -at- gmail.com. On twitter @dishpodcast and instagram @petridishpodcast. References: https://www.sciencemag.org/news/2019/02/nanoparticles-give-mice-night-vision https://www.cell.com/cell/fulltext/S0092-8674(19)30101-1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197025/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308321/ https://www.tandfonline.com/doi/full/10.4161/cib.4.2.14647 https://pubmed.ncbi.nlm.nih.gov/29254313/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870921/ https://www.pnas.org/content/114/28/7343 https://www.mdpi.com/1996-1944/11/7/1116 https://www.sciencedirect.com/science/article/pii/S0142961213010168 https://www.intechopen.com/books/poisoning-in-the-modern-world-new-tricks-for-an-old-dog-/mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans https://academic.oup.com/annweh/article/49/7/575/148203 https://www.nature.com/articles/nnano.2016.88

You've probably heard the exciting news that the RNA vaccines for COVID-19 have been successful in clinical trials and are currently being shipped around the world! While exciting, new technologies can be intimidating and understandably, can raise a lot of questions and concerns. In this episode we review the history of traditional vaccines, explain the science behind RNA vaccines, and answer your questions about this novel vaccine.How vaccines work article: https://www.cell.com/cell/fulltext/S0092-8674(20)31237-XVariolation: https://en.wikipedia.org/wiki/Variolation#:~:text=Variolation%20was%20the%20method%20of,but%20protective%2C%20infection%20would%20result.Vaccine types: https://www.vaccines.gov/basics/typesRNA vaccines: https://www.the-scientist.com/news-opinion/the-promise-of-mrna-vaccines-68202Immune system information: https://www.merckmanuals.com/home/immune-disorders/biology-of-the-immune-system/overview-of-the-immune-system#:~:text=Human%20leukocyte%20antigens%20(HLA)%20are,to%20distinguish%20self%20from%20nonself.&text=An%20immune%20response%20is%20the,immune%20system%20to%20an%20antigen.Moderna vaccine trial info: https://www.statnews.com/2020/11/16/modernas-covid-19-vaccine-is-strongly-effective-early-look-at-data-show/Modern and Pfizer vaccines: https://www.washingtonpost.com/health/2020/11/17/covid-vaccines-what-you-need-to-know/?arc404=trueVaccine efficacy: https://scroll.in/article/979627/a-statistician-explains-what-does-90-efficacy-for-a-covid-19-vaccine-mean Follow us @steministaspod on Twitter and Instagram. You can email us at steministas@gmail.com

In aflevering 24 van onze podcast bekijken we weer enkele opmerkelijke studies : De invloed van darmflora op je gemoedstoestand : https://www.nature.com/articles/s41467-020-19931-2 Het succes van transplantie van stoelgang kan beïnvloed worden de darmflora's van donor en ontvanger eerst op elkaar te alligneren : https://www.nature.com/articles/s41598-020-75162-x Obesiteit heeft een negatieve invlied op immuniteit en versneld de groei van tumoren : https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9 Mensen zijn veel kwetsbaarder voor kanker dan apen : https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2020-00092 Gebruik je smartphone om Covid-19 op te sporen : https://www.cell.com/cell/fulltext/S0092-8674(20)31623-8

A. Metabolismo em Dieta LowCarb O que são calorias O pensamento Calories In Calories Out (CICO) A natureza contra intuitiva do método científico Quais os desafios com o CICO: Ignorar os efeitos hormonais Dieta Flexível Dieta Low Carb aumenta o metabolismo basal mesmo sem restrição calórica (https://www.instagram.com/p/BqDVOiBFpjW/?utm_source=ig_web_copy_link) Dieta Low Carb mantém fluxo de energia constante após refeição (https://www.instagram.com/p/CAu8HZOFJdf/?utm_source=ig_web_copy_link) Dieta Low Carb te dá Crédito Calórico na Manutenção de Peso (https://www.instagram.com/p/CA5H5s9lJbg/?utm_source=ig_web_copy_link) Metanalise mostra que uma dieta lowcarb para gerar efeitos precisa de pelo menos 2,5 semanas na fase de adaptação (https://www.instagram.com/p/CInQ2zCFaG-/?utm_source=ig_web_copy_link) B. Revistas Científicas e Clickbait O que é Clickbait? Mídia tradicional e Clickbait Midia Científica fazendo Clickbait? Estudo do Journal Cell: https://www.cell.com/cell/fulltext/S0092-8674(20)31526-9 Tweet desse estudo: https://twitter.com/CellCellPress/status/1336742738855931908 C. Nutrição Bizarra (Ovos Causam Diabetes?) Hierarquia dos Estudos Científicos Os problemas dos Estudos epidemiológicos: Viés do paciente saudável, Viés de Confusão, Questionários de Frequência Alimentar, Manipulação (Tortura de Dados) Estudos Epidemiológicos sobre o Ovo (https://www.instagram.com/p/CIAowT4Fk6j/?utm_source=ig_web_copy_link, https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/abs/higher-egg-consumption-associated-with-increased-risk-of-diabetes-in-chinese-adults-china-health-and-nutrition-survey/C86D80672A65B06F1220BC3691C18296) Ensaio Clínico Randomizado Envolvendo Ovo e Diabetes (https://www.instagram.com/p/CBdf5iUl0oA/?utm_source=ig_web_copy_link)

Covid-19, tra vaccini e cause profonde. Utilizzare i primi, senza rimuovere le seconde. L’arrivo più o meno certificato dei primi vaccini sta generando un senso di sollievo. Legittimo. Ciò che invece appare illegittimo e inaccettabile, soprattutto agli occhi di alcuni scienziati, è la rimozione delle cause profonde della pandemia che potrebbe accompagnare l’arrivo dei vaccini. Possiamo pensare di debellare Covid-19 ignorando le origini della diffusione del virus Sars-CoV-2? Memos ha ospitato oggi il filosofo delle scienze biologiche Telmo Pievani, grande esperto di teoria dell’evoluzione, docente all’università di Padova, per farsi guidare in un viaggio all’origine del virus. Come siamo arrivati fin qui con la pandemia da Covid-19? Il professor Pievani utilizza come guida un importante articolo scientifico pubblicato recentemente sulla rivista american Cell (https://www.cell.com/cell/pdf/S0092-8674(20)31012-6.pdf). Uno dei due autori è il noto immunologo statunitense Anthony Fauci. Spiega il professor Pievani: “Dopo millenni di convivenza con i virus, negli ultimi vent’anni è successo qualcosa di nuovo: una serie di attività umane, di devastazione dell’ambiente, hanno reso molto più probabile il salto di specie di questi virus dagli animali agli umani. Le attività di deforestazione, di commercio illegale di animali esotici, e così via, ci hanno fatto entrare in un’epoca in cui queste pandemie diventano più frequenti e più violente”. Le azioni umane, dunque, hanno reso gli umani ancora più vulnerabili, fragili. Un tema che Telmo Pievani ha ripreso nel suo ultimo libro “Finitudine. Un romanzo filosofico su libertà e fragilità” (Raffaello Cortina, 2020).

pomeさんをゲストに迎え、TALEN・UCART治療・シングルセル解析・核酸医薬・DNA合成に関する技術と関連のバイオテック企業の動向について話を伺いました。Shownotes Researchat.fm ep79…pomeさんゲスト回前編はこちらです。 TALEN…詳しくはResearchat.fm ep76 Cellectis … Swedenではなく、Franceの企業だったようです。(BB氏訂正ありがとうございました。) CAR-T UCART…Universal Chimeric Antigen Receptor T-cells。”Off-the-shelf”ってかっこいいですね。 T細胞 (Wikipedia) HLA (Wikipedia) NK細胞 (Wikipedia) CD47 (Uniprot) Pfizer Allogene Therapeutics CRISPR (Wikipedia)…Researchat.fmの過去回をお聞きください。Researchat.fm ep76、Researchat.fm ep77など iPS細胞 (Wikipedia) Spatial Transcriptomics 10X Genomics seqFISH FACS (Wikipedia) BioLegend Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets. Cell 2015…InDrop法による１細胞シングルセル解析の元論文 1CellBio Broad Institute アンチセンスRNA 筋ジストロフィー (Wikipedia) 核酸医薬 (Wikipedia) siRNA (Wikipedia) 固相合成 (Wikipedia) 液相合成 T7 (NEB) GenScript TdT (Wikipedia) … 話が途中からDNA合成からRNA合成にすり替わってしまいましたが、RNA合成の基本であるIVT(in vitro transcription)に関してはまたいつか話します。 Molecular Assemblies, Inc Enzymatic DNA synthesis enters new phase. Nature Biotech 2020…TdTを用いたDNA合成の最前線に関する記事(2020/10月) De novo DNA synthesis using polymerase-nucleotide conjugates. Nature Biotech 2018…TdTを用いた核酸合成の元論文。 Moderna…今COVID-19のワクチンで名前を轟かせている製薬会社 さくら通信 さくら剛 (Wikipedia) インドなんて二度と行くか!ボケ!!―…でもまた行きたいかも (Amazon) 感じる科学 (Amazon) 丸山ゴンザレス (Wikipedia) … 通称丸ゴンさん 海外ブラックロード … 丸ゴンさんと嵐よういちさんのポッドキャスト 丸山ゴンザレスの裏社会ジャーニー (Youtube) クレイジージャーニー (Wikipedia) 草下シンヤ … 個人的には草下さんも超気になっている。まさか裏のハローワークの作者だったのか… BLUE GIANT (Amazon) Editorial notes ブルージャイアント読者仲間がいて嬉しかったです。次も面白い漫画の話ししたいですね。(pome) 楽しかったですね、また宜しくお願いします(soh) pomeさん楽しい話をいっぱいありがとうございました。漫画の話いっぱいしたいですね！ (coela) 北欧のいいメタル教えてください、ぐらいのノリでスタートアップを聞いてしまいました。そしてこの音源は10月に収録したものだったのですが、PfizerやModernaのmRNAワクチンのニュースが出る前に公開するべきでした！！！大変申し訳ございません。未来を読んだことにしてくれませんかね？ここはひとつ。pome劇場第二幕に期待…!!!(tadasu)

  Vidcast:  https://youtu.be/EaG0OrjId0U   Those who survive CoVid not only have more anti-viral antibodies, but those they do have are of higher quality.  Harvard immunologists draw this conclusion from their studies of 193 hospitalized CoVid patients comparing those surviving moderate to severe disease with those who perished.   Those who survived CoVid developed antibodies that could effectively bind to spike protein and prevent the virus from invading cell after cell. They also brewed  antibodies that bind to the Fc sites on killer lymphocytes and trigger them to flush away virus-infected cells that would release ever more virus.   This new information will guide vaccine developers to produce agents that evoke even more powerful protective antibodies.   https://www.cell.com/cell/pdf/S0092-8674(20)31459-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420314598%3Fshowall%3Dtrue   #covid #antibodies #spikeprotein #killercells  

This is a podcast which picks up a few interesting things that have appeared in the news in recent weeks. In this episode we have something on health, science and the environment. In health, we learn that indigenous people are probably the best people to give advice and help other indigenous people with the coronavirus. You listen and learn more about this by listening to this interview: https://www.abc.net.au/radionational/programs/latenightlive/fiona-stanley-feature-interview/12785302 In science we discover that octopuses can ‘taste’ with their arms. You can learn more here: https://www.cell.com/cell/fulltext/S0092-8674(20)31149-1?utm_source=EA https://www.newscientist.com/article/2258515-octopuses-taste-their-food-when-they-touch-it-with-their-arms/ And finally, in the environment we learn that sugar gliders in Australia are more diverse that was previously thought. Read more about these lovely animals here: https://www.theguardian.com/environment/2020/nov/06/two-new-greater-glider-species-discovered-australias-biodiversity-just-got-a-lot-richer Worksheet Answers: C   2. C   3. A

dessanをゲストに迎え、CRISPRの仕組みを利用した様々な技術や遺伝子回路、これからの発展について話しました。Show notes The Nobel Prize in Chemistry 2020…The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.” Scientifc Background on the Nobel Prize in Chemistry 2020 A TOOL FOR GENOME EDITING…ノーベル財団による詳細なCRISPR研究のレビュー、そしてなぜDoudnaとCharpentierの二人が受賞に値するのかについて説明している。 76. The Chimeric RNA, Researchat.fm…ゲノム編集についてdessanをゲストに迎えて話しました。 A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 2012…CharpentierとDoudnaによるノーベル賞につながる論文の一つ。CRISPR–Cas9システムがこの論文によってその大枠が明らかにされた。 Multiplex Genome Engineering Using CRISPR/Cas Systems. Science 2013…Feng Zhang labによるヒト細胞におけるゲノム編集技術の報告。 RNA-Guided Human Genome Engineering via Cas9. Science 2012…George Church labによるヒト細胞におけるゲノム編集技術の報告も同時に掲載された。 First rounders: Feng Zhang (Podcast)…Feng Zhangが出演したNatute Biotechnologyのポッドキャスト。おすすめです。 26. Cool tech googlability, Researchat.fm…RNAを標的にできるCas13bについては、エピソード26で紹介しました。 Cas14 (crisp_bio)…“Cas14は、PAMに依存しないssDNA切断活性に加えて、PAMに依存するdsDNA切断活性も帯びている” CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature 2019…CasX Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration. Nature 2019…トランスポゾン型のCasシステムの報告。 RNA-programmed genome editing in human cells. eLife 2013…Doudna labによるヒト細胞におけるゲノム編集技術の報告。FengやChurchらよりも少しだけ遅かった。 Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9. Nature Communications 2014 Ep52. Split into a row Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell 2013…Double nicking (2つのgRNAとCas9 nickase)によるより正確なゲノム編集方法が示された。 Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 2015…Cas9を用いた転写の活性化手法。 Live visualization of chromatin dynamics with fluorescent TALEs. Nature Structural & Molecular Biology 2013 … TALENを用いた染色体の特定領域のイメージング方法 Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System. Cell 2013…dCas9-EGFPによる生細胞のイメージング技術。SpCas9の場合は、D10AとH840Aの２つの変異を入れることで、DNAに結合するが切断しないdead Cas9 (dCas9)として利用することができる。 Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9. Nature Communications 2017…ガイドRNAにMS2 loopをたくさんつなげることで (14個!)、明るい輝点を得ることができる。 CRISPR-mediated live imaging of genome editing and transcription. Science 2019…こちらは蛍光標識したガイドRNAを利用した生細胞イメージング方法。 A protein tagging system for signal amplification in gene expression and fluorescence imaging. Cell 2014…Sun tagとCas9を用いたイメージング方法。 Split Green Fluorescent Proteins: Scope, Limitations, and Outlook…Split GFP Programmable RNA tracking in Live Cells with CRISPR/Cas9. Cell 2016…PAMmerによるSpCas9のmRNAイメージング CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell 2018 … CRISPR-GO：CRISPR技術、核内でのゲノム空間構造、ポッドキャスト内ではゲノム同士を寄せるという説明をしていましたが、今調べてみると特定のゲノム領域と核膜やカハール体への再配置ということでした。 Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Nature Communications 2017 … こちらがCRISPRの仕組みを用いることで人工的に染色体内部にループを作成した論文。 Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 2008 … LacO-LacIの仕組みを用いることでゲノムの特定領域にLacO arrayを差し込み、核膜に局在させたLacIに結合させることである遺伝子領域を核膜側に誘導しようとした論文。最初にこの論文を読んだ時はそのアイデアにたまげました。 9. One-shot beautiful experiment (Researchat.fm)…人工的なDNA領域へ細胞内の情報（細胞系譜）を書き込む技術についてエピソード9で話しました。 CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature 2017…George Churchらは、Cas1-Cas2システムによって馬の動画をバクテリアゲノム書き込み、それを読み出すことに成功した。 Multiplex recording of cellular events over time on CRISPR biological tape. Science 2017…コピー数の異なる2つのプラスミドをCas1-Cas2で取り込ませて、細胞内で人工的な時計のような仕組みを実現した。 Single-Nucleotide-Resolution Computing and Memory in Living Cells. Molecular Cell 2019…Tim Liu Labによる複雑な遺伝子回路の実現。DOMINOについては、プロモーター配列を標的にしているのではなくオペレーター配列でした。 Rewritable multi-event analog recording in bacterial and mammalian cells. Science 2018…David Liu labから報告されたガイドRNAによって連鎖する遺伝子回路（カスケード）の実現。 Terminal Deoxynucleotidyl Transferase, TdT…テンプレートに依存しないDNA合成を可能にする酵素。 Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Nature Biotechnology 2012…GFP Timer Permanent genetic memory with >1-byte capacity. Nature Methods 2014 Continuous genetic recording with self-targeting CRISPR-Cas in human cells. Science 2016…自分で自分のガイドRNAを編集することで、理論的には無限に情報を書き込む方法が提案されたが、領域が壊れてしまう問題もある。 Ten Simple Rules to Win a Nobel Prize. ヘンリー・ブラッグ (Wikipedia) iPS細胞 (Wikipedia) 国境なき医師団 Human Genome Project Xiaowei Zhuang Expansion microscopy (Wikipedia) Renato Dulbecco (Wikipedia) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology 2019…LEAPER crisp_bio … 世界広しといえでも、これだけCRISPRの最新情報がまとまっているサイトはCRISP_BIOさんの他に世の中には存在しません。日本語でCRISPRの最先端情報を追える喜び。CRISP_BIOさん、いつもありがとうございます。 Editorial notes 1分でわかるとか無理なのですが、一方で言葉を尽くせばわかる可能性についても同時に信じておりますので…(soh) 思い出しながらどんどん話しているので、後から聞き返すと細部が間違っていたりしています。気になった方はshow notesをご参照ください。(dessan) いい感じのグルーヴがみられてよかったです。ポッドキャストやってきてよかったです。(tadasu) 最初に喋らんと出番が無くなる！と思ってこれまでの流れをまとめてみたんですが細かく色々ミスってました…(coela)

This week we dive into our favorite award season! Nobel Prize week! We break down the 2020 winners of the Physiology and Medicine, Physics and Chemistry prizes and share some fun facts and stories about past Nobel winners. Visit nobelprize.org for information on all laureates! Episode Breakdown: 0:10-Intro and catchup 3:46-Woman Scientist of the episode 5:26-Nobel Fun Facts 9:40-Physiology or Medicine Award 14:00-Physics Award 16:50-Chemistry Award 28:00-Fun Nobel Stories Papers mentioned: Alter et al. Clinical and serological analysis of transfusion-associated hepatitis, The Lancet (1975). Alter et al. Transmissible agent in non-A, non-B hepatitis, The Lancet (1978) Kolykhalov et al.Transmission of Hepatitis C by Intra hepatic Inoculation with Transcribed RNA, Science (1997) The Heroes of CRISPR (https://www.cell.com/cell/pdf/S0092-8674(15)01705-5.pdf)

Resources:Representation in science: https://www.cell.com/cell/pdf/S0092-8674(20)30740-6.pdfParachute research:https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30239-0/fulltextThe culture of research and how it needs to change: https://www.forbes.com/sites/madhukarpai/2019/11/10/global-health-research-needs-more-than-a-makeover/#71523e2a7e34Covid-19 and overlooked research from the global South: https://www.theguardian.com/commentisfree/2020/may/21/africa-coronavirus-successes-innovation-europe-usDiversity and Inclusion podcast: https://www.mildon.co.uk/podcastGuest information:Diversity and inclusion in academic institutions Soundbite: Dr. Ozama Ismail  is a neuroscientist studying dementia.  He co-founded the Minorities in STEM network, and is passionate about raising LGBTQ+ voices within science and ethnic minority groups. Oz co-hosts "Why Aren't You A Doctor Yet?" which tells compelling and diverse stories, combining science and tech with popular culture and comedy. @MinoritySTEMIjeoma Uchegbu is Professor of Pharmaceutical Nanoscience, Pro-Vice Provost for Africa and The Middle East  at University College London. She is Chief Scientific Officer of Nanomerics Ltd, editor of three books, a named inventor on 11 granted patents and has authored over 180 peer reviewed journal articles and book chapters.Dr. Saher Ahmed is Head of Equality, Diversity and Inclusion at Genome Research Limited. Saher has 15 years’ experience working in the area of EDI and has set-up national projects and organisational strategy. Saher completed her PhD in Nuclear Physics at the University of Birmingham, UK and has two children @EqualityScience AcknowledgementsEditing by Mariana Vaz, https://www.marianacpvaz.com/Research: Alice Matimba, Isabela Malta, Christine Boinett and Emmanuela OppongProducers: Alice Matimba (Senior Producer), Isabela Malta (Producer), Christine Boinett (Creator and Executive producer) and Emmanuela Oppong (Producer).Host: Isabela Malta (Part 1), Christine Boinett (Part 2), Alice Matimba (Part 3 & 4)Media and Marketing: Catherine HolmesMusic: https://freesound.org/s/477388/Sponsors:Wellcome Genome Campus Advanced Courses and Scientific ConferencesWellcome Sanger InstituteSocial Entrepreneurship to Spur Health

Resources:Representation in science: https://www.cell.com/cell/pdf/S0092-8674(20)30740-6.pdfParachute research:https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30239-0/fulltextThe culture of research and how it needs to change: https://www.forbes.com/sites/madhukarpai/2019/11/10/global-health-research-needs-more-than-a-makeover/#71523e2a7e34Covid-19 and overlooked research from the global South: https://www.theguardian.com/commentisfree/2020/may/21/africa-coronavirus-successes-innovation-europe-usDiversity and Inclusion podcast: https://www.mildon.co.uk/podcast Guest informationSoundbite: Dr. Yolanda Ohene is a researcher at UCL specialising in developing novel MRI techniques. She is the co-founder of the Minorities in STEM network, and project head for two Minority in STEM symposia: Expanding Diversity and Level Up Your Academic Toolbox, to support, connect and showcase ethnic minorities in STEM fields. @MinoritySTEM @y_ohene Interview 1: Sabrina Fleurimé from BBSTEM; Representation matters.BBSTEM is a non profit organisation campaigning for balance and representation of Black individuals in science, technology, engineering and mathematics. I am the Corporate Partnership Coordinator collaborating with various institutions to bring exciting opportunities to the talented individuals of our network. I am also a full time scientist working on Drug Development at a biotech in Cambridge. Twitter: @BB_STEM  Website: www.bbstem.co.uk Interview 2: Prof. Iruka Okeke; Equity in academic researchIruka N Okeke is a Professor of Pharmaceutical Microbiology at the University of Ibadan, Nigeria and a Fellow of the Nigerian and African Academies of Science.  Her research group investigates the mechanisms bacteria use to colonize humans, cause disease and gain drug resistance.  She also studies laboratory practice in Africa. Follow Iruka: @iruka_okeke Interview 3: Prof. Eva Maria C. Cutiongco-de la Paz; Equity in academic researchProf. Eva Maria C. Cutiongco-de la Paz is Professor of Pediatrics and Genetics and Executive Director of the National Institutes of Health, University of the Philippines, Manila. She serves as the Director of the Health Program of the Philippine Genome Center.  Interview 4: Prof. Collet Dandara; Ensuring equity from the beginning Professor Collet Dandara is a Professor of Human Genetics, Principal Investigator of the Pharmacogenomics and Drug Metabolism Research Group at the University of Cape Town, South Africa. Twitter: @col_codza Time stamps:01:05 - Sabrina Fleurime, BBSTEM11:37 - Prof. Iruka Okeke41:21 - Prof. Eva Maria C. Cutiongco-de la Paz01:04:43 - Prof. Collet Dandara AcknowledgementsEditing by Mariana Vaz, https://www.marianacpvaz.com/Research: Alice Matimba, Isabela Malta, Christine Boinett and Emmanuela OppongProducers: Alice Matimba (Senior Producer), Isabela Malta (Producer), Christine Boinett (Creator and Executive producer) and Emmanuela Oppong (Producer).Host: Isabela Malta (Part 1), Christine Boinett (Part 2), Alice Matimba (Part 3 & 4) Sponsors:Wellcome Genome Campus Advanced Courses and Scientific ConferencesWellcome Sanger InstituteSocial Entrepreneurship to Spur HealthMedia and Marketing: Catherine HolmesMusic: https://freesound.org/s/477388/

In this episode, Eugenio, Jatin, and Natalie discuss about the a the role T cells in anxiety in murine models. Check out our memes on Facebook (@antibuddies) and Twitter (@antibuddiesP). Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com.   Source: https://www.cell.com/cell/fulltext/S0092-8674(19)31117-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419311171%3Fshowall%3Dtrue

Mozek je jedno velké společenství. Když nahlédnete za oponu lebky, spatříte orgán lině se převalující ze strany na stranu v mozko-míšní tekutině. Uvnitř něj se skrývají dosud neobjasněná tajemství lidské mysli. Miliardové populace buněk spolupracují, abychom mohli chodit, myslet, učit se, milovat a žít život naplno. Rozsvěcující se neurony však tvoří jen část z nich. A co tvoří ten zbytek? Neurony jsou jako drahé kabely pro přenos velmi cenných informací, Proto vedle nich existují miliardy buněk, které je podporují, dodávají živiny a udržují rovnováhu - Gliové buňky jako jsou Mikroglie, Oligodendrocyty, Astrocyty a další. K čemu v mozku jsou? Které fungují jako ochrana a které podporují paměť? Mohou nám kešu oříšky pomoci s prevencí demence? To vše se dozvíte ve dnešním studiemi nabitém dílu. Přejeme příjemný poslech! Chceš-li nám pomoci šířit info o mozku, sdílej tento díl s hashtagem #PrevenceDemence Zadej kód "BWA" pro 10% na náš biohackingový online kurz Zadej kód "BWA" pro 10% slevu na UpLife.cz Podpořte nás jednorázově nebo na startovači Sledujte Brain We Are na sociálních sítích: Instagram nebo Facebook "Tento podcast slouží pouze pro vzdělávací účely. Neberte informace v něm zmíněné jako lékařskou radu" Minutáž: 02:40 - Co jsou to Glie a jakou mají v mozku funkci? 03:42 - Jak Mikroglie ovlivňují neuroplasticitu a paměť? 05:30 - PTSD trauma a Mikroglie 08:40 - Co jsou to Oligodendrocyty a jak formují paměť? 10:00 - Jak KEŠU oříšky podporují paměť a oligodendrocyty? 11:10 - PTSD trauma kódované v mozku 12:30 - Co jsou to Astrocyty a jak ovlivňují chování rezignace? Zdroje: Mikroglie a PTSD: https://www.cell.com/cell/fulltext/S0092-8674(20)30683-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420306838%3Fshowall%3Dtrue Kešu a Oligodendrocyty: https://www.pnas.org/content/117/35/21527 Astrocyty: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080721/#:~:text=4779%2D97A5%2DE815F4611201-,SUMMARY,ion%20buffering%20and%20metabolite%20delivery.&text=This%20global%20stimulation%20of%20astrocytes,of%20norepinephrine%20from%20the%20brain. Mikroglie a stress: https://www.biologicalpsychiatryjournal.com/article/S0006-3223(18)31942-5/fulltext Upozornění: Poměr Glií k neuronům 9:1 je zpochybňován nedávnými studiemi a pokrokem technologií počítání nervových buněk. Dlouho příjmané informace o tom, že "Glií je v mozku 90%", které jsme použili i v tomto díle, tak už nejsou aktuální. https://pubmed.ncbi.nlm.nih.gov/27187682/

染色体分配時におけるKi-67の機能性に関する論文を紹介しました。Show notes 周期ゼミ Periodical cicadas … 全米における周期ゼミの分布について 論文の縦読み … 同じオーサーの論文を時間軸で読む、論文の縦読みについてはresearchat.fmのep57にて説明しました。 Cuylen-Haering et al., Nature (2020) … “Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly” Gerlich et al. Cell (2003) … “Global Chromosome Positions Are Transmitted through Mitosis in Mammalian Cells” Cuylen et al., Nature (2016) … “Ki-67 acts as a biological surfactant to disperse mitotic chromosomes” Samwer et al., Cell (2017) … “DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes” Daniel Gerlich 植物の細胞で染色体が分配される様子 … 1956に撮影されたAfrican Blood Lilyの細胞における染色体分配と細胞分裂の様子。植物には中心体が存在しないので少し動物細胞のものとは趣が異なる。64年前に撮影された動画だが未だ色褪せず様々な洞察を与えてくれる。無染色・ライブセルで行われた驚異的なイメージング。 上記動画に関するツイート … 海外勢もかなりコメントをくれているのがわかる。 体細胞分裂 … prophase->prometaphase->metaphase->anaphase->telophase->cytokinesis。英語だとmitosis DNA複製 遺伝情報 減数分裂 … 英語だとmeiosis HeLa細胞 染色体 核(細胞核) ミトコンドリア … パラサイト・イヴでご存知の方も多いだろう。 細胞小器官 核小体 … 仁とも呼ばれていた。 リボソーム リボソームRNA 倍数性 姉妹染色体/姉妹染色分体 コヒーシン … 姉妹染色体を接着させるために重要なタンパク質 Locke. JCS (1990) … “Is there somatic inheritance of intracellular patterns?” transvection mitophagy ヒストン ヌクレオソーム クロマチン … ヒストン、ヌクレオソーム、クロマチン、染色体についてはどこかでじっくり話します。 CFP, YFP … 蛍光タンパク質 細胞周期 … G1->S->G2->M. G1->S->G2が間期、Mが分裂期 FRAP(Fluorescence recovery after photobleaching) FISH Kimura and Cook. J Cell Biol (2001) … “Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B” 染色体テリトリー Cremer and Cremer. Cold Spring Harb Perspect Biol. (2010) … “Chromosome Territories”: ドンピシャタイトルのThomas CremerによるChromosome territoryのレビュー。 Carl Rabl Theodor Boveri Sutton-Boveriの染色体説 キネトコア セントロメア スピンドル … 紡錘体 微小管 … microtuble RNAi ki-67 G0期 核膜 核膜孔 open mitosis/closed mitosis Nuclear envelope break down … 核膜の崩壊 ノコダゾール コルヒチン FCS 両親媒性 Crasta et al., Nature (2012) … “DNA breaks and chromosome pulverization from errors in mitosis” micro nucleiに関する最近の代表的な研究 スプライシング コンデンシン Delarue et al. Cell (2018) … “mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding”: GEMs(genetically encoded multimeric nanoparticles)を開発した論文。これは激アツである！ Akita et al., JCS (2007) … “The crystal structure of a virus-like particle from the hyperthermophilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses”: Delarue et al. (2018)で使われたencapsulinに関する論文。これも激アツである！ 養王田先生の科研費報告書 … “Encapsulinとは単一のシェルタンパク質で構成される内部が空洞のナノ構造体であり、一部の微生物細胞内に形成されている。” 核移行シグナル Görisch et al., JCS (2005) … “Histone acetylation increases chromatin accessibility”: クロマチンへのaccessibilityをイメージングで示そうとした論文 Dextran Flavopiridol Trichostatin A (TSA) Angelika Amon Breakthrough Prize in Life Sciences 染色体の異数性 … aneuploidy 出芽酵母 Ünal et al., Science (2011) … “Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast”: 老化した出芽酵母は減数分裂に進みにくいことを示した定量解析。Amon labからの研究。 King et al., eLife (2019) … “Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast”: 上記のFirst authorであるÜnal labから出た論文。年老いた出芽酵母が減数分裂に進んだ場合の”Nuclear rejuvenation”(核若返り)に関するイメージング研究 エピジェネティクス(epigenetics) Conrad Hal Waddington … epigeneticsの提唱者。 Editorial notes 素人にもロジックが追いやすかった気がする (soh) 綿々と続くドイツの細胞生物学/染色体学研究の系譜はまたどこかで話せたらと思います。(tadasu) figureがモンスターボールみたいですね (coela)

In this episode of the Epigenetics Podcast, we caught up with Geneviève Almouzni, Ph.D., Research Director at the CNRS at Institut Curie in Paris, to talk about her work on the regulation of chromatin organization by histone chaperones. Geneviève Almouzni got her Ph.D. from Université Pierre-et-Marie-Curie in 1988 under the supervision of Marcel Méchali. She then moved to the United States to work as a postdoc in the National Institutes of Health in the laboratory of Professor Alan Wolffe. In 1994, she returned to Paris and became a Junior Group Leader at Institut Curie and became a Group Leader there in 2000. In 2013, she took over the direction of research at the Institut Curie and became the third woman to hold this position, after Marie Curie and Irène Joliot-Curie. Geneviève Almouzni’s research focuses on the assembly of chromatin and the identification of histone chaperones. Histone chaperones are necessary for the establishment and maintenance of chromatin, as they help to assemble the nucleosomes out of the core histones and DNA. This occurs both when the polymerase transcribes through a nucleosome and after DNA replication and repair. The Almouzni group has identified and characterized multiple histone chaperones, including CAF-1, HirA, and HJURP. Furthermore, they investigated how post-translational modifications on soluble histones influence the final epigenetic state of the nucleosome and the reassembly of chromatin after DNA replication. In the last couple of years, the group has focused on the unraveling the link between the structure of chromatin at centromeres and cancer. In this interview, we discuss the focus of the Almouzni lab on histone chaperones, how the lab was able to identify its first one with CAF-1, how histone PTMs on soluble histones influence the deposition on the DNA, and how the chromatin on centromeres is involved in cancer.   References   Dominique Ray-Gallet, Jean-Pierre Quivy, … Geneviève Almouzni (2002) HIRA Is Critical for a Nucleosome Assembly Pathway Independent of DNA Synthesis (Molecular Cell) DOI: 10.1016/S1097-2765(02)00526-9 Pierre-Henri L. Gaillard, Emmanuelle M.-D. Martini, … Geneviève Almouzni (1996) Chromatin Assembly Coupled to DNA Repair: A New Role for Chromatin Assembly Factor I (Cell) DOI: 10.1016/S0092-8674(00)80164-6 Jean-Pierre Quivy, Danièle Roche, … Geneviève Almouzni (2004) A CAF-1 dependent pool of HP1 during heterochromatin duplication (The EMBO Journal) DOI: 10.1038/sj.emboj.7600362   Contact   Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on Linked-In Active Motif on Facebook eMail: podcast@activemotif.com  

This is the sixth and last episode that covers the health and safety of aspartame.   We discuss how aspartame could negatively affect gut microbiota. The second half of the episode I provide my two cents on aspartame.   Disclaimer: Any information provided in this episode is solely for educational purposes. I'm not a medical professional. So in no way is the information provided in any episode of this podcast to be used as a substitute for talking with a medical professional.   In addition, my intent is not to claim that aspartame is bad for you. There's a ton of research that list its possible negative effects. However, there's a plethora of research that explains that aspartame is safe if consumed at or below the acceptable daily intake. Listen to the podcast, do your research and come to your own conclusion.   The trailer for the movie my friend wrote, directed and acts in 'Distance To Empty' is on Kickstarter. The campaign is over, but we're looking at other means to raise money to produce the feature length film.   Please check out the trailer.   http://kck.st/3cZvKQw   Intro music provided by @britonbeats Check out the Instagram page.   Questions/Comments:   Head over to howardsblend.com, and click Contact Us, or   email howard@howardsblend.com   You can also find me on social media...   Instagram @howardsblend   LinkedIn Howard Blend   If you enjoy and find value in this show's content, please leave a review on Apple Podcasts, leave a 5 star rating on Apple Podcasts, and subscribe on Apple Podcasts.   If Apple Podcasts is not your preferred platform, then you can listen to this show on howardsblend.com(recent episode), Google Play, Spotify, and Stitcher.   T-shirts with the Howard's Blend logo are now available on howardsblend.com as well.  If you need a new t-shirt and want to support the show, then head on over to the site to check it out.   Resources: https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750029.html https://academic.oup.com/nutritionreviews/article/75/9/718/4101228 https://www.uofmhealth.org/health-library/tw12861 https://www.tandfonline.com/doi/abs/10.1080/1028415X.2017.1288340?journalCode=ynns20 https://www.livescience.com/54901-free-radicals.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806654/ https://www.ncbi.nlm.nih.gov/books/NBK22591/ http://www.chemistry.wustl.edu/~edudev/LabTutorials/hemoglobin.htm https://www.sciencedaily.com/releases/2018/05/180530144120.htm https://www.heart.org/HEARTORG/Encyclopedia/Heart-Encyclopedia_UCM_445084_Encyclopedia.jsp?title=myocardium https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/myocytes https://www.healio.com/hematology-oncology/learn-immuno-oncology/the-immune-system/adaptive-immunity-humoral-and-cellular-immunity   https://www.cell.com/fulltext/S0092-8674(08)01071-4   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312722/          

First it was all about biomarkers. Then panels of biomarkers. But biology is complicated. Why does one patient respond to an immuno therapy when another which shares the same biomarker does not? Welcome to the age of spatial biology. Garry Nolan joins us today. He's a professor in the Department of Pathology at Stanford who's career has been a journey of seeing intracellular happenings more and more in context. Check out this cool analogy from a new paper his lab put out in Cell.

Jasmin erzählt eine Geschichte aus ihrem neuen Sachbuch "Abschied von Hermine", das bald angekündigt wird. Es geht um Eintagsfliegen, die nur 5 Minuten erwachsen sind und um Quallen, die niemals sterben müssen. Lorenz erzählt eine Geschichte über die Dünndarm-Zeitschaltuhr, zu deren Erforschung er selbst beigetragen hat (wenn auch nicht im Selbstversuch). Was im Mäuse-Dünndarm passiert, wenn zu unterschiedlichen Zeiten mal fettreiche Kost verabreicht wird, mal Antibiotika, mal Kot, oder die Mäuse währenddessen unter Jetlag leiden, erfahrt ihr in dieser Geschichte. Außerdem erzählt Lorenz, warum er eine Wespe heiraten würde. (Foto: Richard Bartz) Material • Paper zu Dolania americana: https://onlinelibrary.wiley.com/doi/abs/10.1002/iroh.1977.3510620306 • Wikipedia-Artikel über die "unsterbliche Qualle": https://de.wikipedia.org/wiki/Turritopsis_dohrnii • Die von Lorenz besprochene Arbeit gibt es hier jedoch leider nur hinter der Bezahlschranke: https://www.cell.com/cell/fulltext/S0092-8674(20)31069-2

Die heutige Folge beginnt damit, dass Jasmin Lorenz erzählt, wieso sie Pilze für die absoluten Overlords hält. Sie berichtet, wie manche von ihnen Steine essen können und wieso einige Pilze an Orchideen Schutzgeld in Form von Zucker abdrücken müssen. Und falls ihr euch mal gefragt habt, ob ihr lebendig verschimmeln könntet: Auch dazu gibt es die Antwort. Anschließend spricht Lorenz vom Schlafmangel bei Fruchtfliegen. Setzt man die Kerlchen auf Schlafentzug, reichern sich in ihren Därmen Sauerstoffradikale (“ROS”) an, bevor die Tiere frühzeitig versterben. Was man dagegen tun kann und wieso man das dennoch nicht nachahmen sollte, um für immer wach zu bleiben, erzählt er euch ebenfalls. Am Schluss gibt es noch einen Exkurs zum Kettensägentier. Was das ist, wieso wir trotz heftigen Schneidens immer noch 10 Minuten darüber reden und was Jasmins Hamster damit zu tun habt, erfahrt ihr, wenn ihr die Folge hört. Viel Spaß! Material • Ein Artikel der Uni Würzburg über eine Infektion mit Aspergillus-Pilzen: https://www.uni-wuerzburg.de/fileadmin/uniwue/Presse/BLICK_1-2007/17aspergillus.pdf • Original-Arbeit zur ROS-Kur bei Fruchtfliegen-Schlafmangel: https://www.cell.com/cell/fulltext/S0092-8674(20)30555-9

T2E55 - Moho mucilaginoso que mapea, carne de gallina y pelos erizados y conexiones genéticas entre pueblos polinesios y americanos En este episodio, nos asombramos de las capacidades de resolución de problemas de un moho mucilaginoso que se ha vuelto muy famoso, nos enteramos de una explicación adicional para la carne de gallina (o piloerección) y, en entrevista con Andrés Moreno, nos fascinamos por el trabajo que ha develado conexiones genéticas entre pueblos polinesios y americanos. Menú 00:20 - Saludos y presentaciones 03:46 - Physarum y un mapa de la materia oscura 28:19 - Otra razón biológica para la carne de gallina 51:59 - Entrevista con Andrés Moreno, sobre el estudio que encuentra conexiones genéticas entre poblaciones humanas de Polinesia y América 01:19:03 - Despedidas y agradecimientos 01:27:15 - ¡BONUS! Nuestro entrevistado de cerca Entrevistado : Andrés Moreno Voces y contenido: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Producción: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Edición: Víctor Hernández Voz en la rúbrica: Valeria Sánchez Este podcast es producido desde un lugar de la Ciudad de México donde a veces se acumula moho, pero nunca tanto como para preocuparnos de que vaya a solucionar nuestros problemas sin que se lo pidamos. Fuentes y lecturas recomendadas Nota sobre el artículo del mapa cósmico y Physarum: https://astronomy.com/news/2020/03/slime-mold-helps-astronomers-map-the-universes-dark-matter Y un video divulgativo: https://www.youtube.com/watch?time_continue=60&v=cAGNTjorz58&feature=emb_logo El los proyectos con Physarum del artista Sage Jenson: https://www.sagejenson.com/physarum El artículo original de los pelos erizados: https://www.cell.com/cell/pdf/S0092-8674(20)30808-4.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420308084%3Fshowall%3Dtrue Cobertura en inglés: https://news.harvard.edu/gazette/story/2020/07/the-hair-raising-reason-for-goosebumps-is-revealed/ Y cobertura en español: https://www.ticbeat.com/innovacion/cientificos-de-harvvard-descubren-secreto-biologico-piel-de-gallina/ El artículo original de Andrés Moreno y sus colegas: https://www.nature.com/articles/s41586-020-2487-2 Cobertura periodística en español: https://elpais.com/ciencia/2020-07-08/los-nativos-americanos-y-los-polinesios-entraron-en-contacto-siglos-antes-de-que-llegaran-los-europeos.html Música y audios Intro y salida: Little Lily Swing, de Tri-Tachyon, bajo una licencia Creative Commons 3.0 de Atribución: freemusicarchive.org/music/Tri-Tachyon/ Sección personal: The Zeppelin de Blue Dot Sessions bajo licencia tipo Attribution-NonCommercial License. Rúbrica: Now son, de Podington Bear, freemusicarchive.org/music/Podington_Bear/ Bajo una licencia Creative Commons Internacional de Atribución No Comercial 3.0 The Blob, para la película homónima de 1958 (pongan atención a la letra): https://www.youtube.com/watch?v=AK5jyVCdXwc Fragmento del inicio de la serie "Escalofríos": https://www.youtube.com/watch?v=BarSC9HTjms "E'ruru era", música tradicional rapa nui: https://www.youtube.com/watch?v=e-QPzfjb6v4

“What will people say is a concept that has either ruined dreams or spurred people on, in order to prove the haters wrong” In Episode 4, I try and figure out why we care so much about other people’s opinions. Going back to basics and analysing the sociology behind it as well as why it’s so prominent in collectivist cultures like South Asian. I'll also share tips on what we can do overcome the fear and literally not care about others opinions. ———————————————————— Don’t forget to follow me on social media: Instagram: https://www.instagram.com/preetipersonal/ Twitter: https://twitter.com/preetipersonal If you prefer, you can also email me: itspreetipersonal@gmail.com New episodes every Tuesday! Don’t forget to follow/ subscribe to Podcast and leave a review ————————————————————— Articles & academic papers used in this episode: Macdonald, Geoff & Saltzman, Jennifer & Leary, Mark. (2003). Social approval and trait self-esteem. Journal of Research in Personality. 37. 23-40. 10.1016/S0092-6566(02)00531-7. https://bit.ly/2USznAm https://www.verywellmind.com/what-are-collectivistic-cultures-2794962 UK Government Forced Marriage statistics 2018: https://bit.ly/3fqD5Jo ————————————————————— Music: Upbeat-party by scottholmesmusic.com Sound effects obtained from https://www.zapsplat.com

T2E53 - Ropa olorosa y hormonas, una coreografía molecular del ejercicio y un mejor periodismo de ciencia Este episodio tiene escala molecular, pero sólo porque las moléculas conforman, pues... todo: hablamos de las posibles conexiones entre el olor corporal de un sexo y las hormonas del otro, al tiempo que cuestionamos por qué hay tanto enfoque en uno de los dos; nos enteramos de la intrincada coreografía molecular que ocurre tras hacer ejercicio y cómo eso nos motiva a no abandonarlo hoy, y, con la guía de nuestra invitada, Aleida Rueda, analizamos la respuesta de los medios a un estudio mexicano que sugiere estudiar más una molécula ya conocida pero en el contexto pandémico, al tiempo que lanzamos un anhelo colectivo por mejorar la relación entre periodismo, ciencia y público. Menú 00:20 - Inicio y presentaciones 03:33 - El olor corporal y niveles de testosterona 29:07 - La coreografía (molecular) del ejercicio 55:17 - El sofosbuvir y el periodismo de ciencia 01:37:54 - Sección personal, con Aleida Rueda Invitada: Aleida Rueda Voces y contenido: Aleida Rueda, Sofía Flores, Rodrigo Pacheco y Víctor Hernández Producción: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Edición: Víctor Hernández Voz en la rúbrica: Valeria Sánchez Este podcast es producido desde un lugar en la Ciudad de México donde alguna vez se dejó olvidado un suéter, pero no son los vestidores de un gimnasio ni la mesa de bocadillos de una conferencia de prensa. Fuentes y lecturas recomendadas Sobre el estudio del olor: El artículo original, en inglés, de acceso abierto: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230838 Sobre la coreografía molecular: El artículo original, en inglés, de acceso abierto: https://www.cell.com/cell/pdf/S0092-8674(20)30508-0.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420305080%3Fshowall%3Dtrue Sobre periodismo de ciencia: El artículo original de Lazcano y sus colaboradores, en inglés de accesp abierto: https://www.nature.com/articles/s41598-020-66440-9 Más que cobertura en español, les dejamos una conferencia de Rosa María del Ángel sobre antivirales y el SARS-Cov2, en un ciclo coordinado por Antonio Lazcano: https://www.youtube.com/watch?v=5qM8nUA1m-U La página de la Red Mexicana de Periodismo de Ciencia: https://redmpc.wordpress.com/ Un foro organizado recientemente por ellos, en el contexto de la pandemia: https://redmpc.wordpress.com/que-hacemos/forohpc-2020/ El proyecto covid-conciencia: https://redmpc.wordpress.com/covidconciencia/ Música y audios Intro y salida: Little Lily Swing, de Tri-Tachyon, bajo una licencia Creative Commons 3.0 de Atribución: freemusicarchive.org/music/Tri-Tachyon/ Sección personal: The Zeppelin de Blue Dot Sessions bajo licencia tipo Attribution-NonCommercial License. Rúbrica: Now son, de Podington Bear, freemusicarchive.org/music/Podington_Bear/ Bajo una licencia Creative Commons Internacional de Atribución No Comercial 3.0 Los olores del amor, de Amílcar Boscan: https://www.youtube.com/watch?v=zYjjTOhfNP4 Escándalo, de la Sonora de Margarita, nuestra diosa: https://www.youtube.com/watch?v=Y-2sehbmdeE Let's Get Physical Work Out, de Dua Lipa: https://www.youtube.com/watch?v=YvVonQ7LUJ0

Back by no demand, it's episode 2. In this episode Laurie and Ben chat through the latest ancient DNA research shedding new light on how the Americas were populated, 15,000 years of earache, and the discovery of a 7th century English saint with the best miracles you've never heard of. Show Links: https://www.archaeology.org/news/8709-200521-native-american-ancestorhttps://www.sciencemag.org/news/2020/05/oldest-cousin-native-americans-found-russia#https://www.cell.com/cell/pdf/S0092-8674(20)30502-X.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742030502X%3Fshowall%3Dtrue  https://www.haaretz.com/archaeology/.premium-archaeology-of-ear-infections-shows-farming-didn-t-ruin-our-health-1.8860082

In deze episode weer heel wat interessant onderzoek. We hebben het deze keer over : Mensen die reeds Covid-19 hebben gehad blijken toch een duidelijke reactie te ontwikkelen tegen het Corona-virus. (https://www.cell.com/cell/pdf/S0092-8674(20)30610-3.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420306103%3Fshowall%3Dtrue). De negatieve bias die mensen hebben tov vuile mensen is ook gerelateerd aan het stigma dat mensen hebben die reeds Covid-19 hebben gehad. (https://www.sciencedirect.com/science/article/abs/pii/S0022096519305272?via%3Dihub) Wat zijn de mogelijke gevolgen als de griep nu ook terugkomt (terwijl er nog Covid-19 is). (https://news.northwestern.edu/stories/2020/05/when-covid-19-meets-flu-season/&fj=1) Er is een link tussen wat er gebeurt in de darmflora en je geheugen (https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00817-w) Zeer vette maaltijden hebben een negatieve invloed op je concentratievermogen (https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqaa085/5835679?redirectedFrom=fulltext) Waarom voel je geen pijn maar wanneer je een algemene verdoving krijgt? https://www.nature.com/articles/s41593-020-0632-8 Wat zijn de belangrijkste beschermingsfuncties van de huid en hoe werkt dit? http://genesdev.cshlp.org/content/early/2020/05/28/gad.333674.119

RNA分子の空間的な近接性を計測するRIC-seqという手法について、原著論文を紹介しました。Shownotes RIC-seq for global in situ profiling of RNA–RNA spatial interactions. Nature 2020…今回紹介したRIC-seqの原著論文へのリンク。 核酸の二次構造 (Wikipedia) RNA結合タンパク質 MBLライフサイエンス ノンコーディングRNA動態解明の最前線 (pdf) Micrococcal Nuclease, NMase (NEB) Ep16, Researchat.fm…エピソード16では分子の近接性から空間構造を再構成するさまざまな方法について解説しています。 Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome. Science 2009…Hi-C法のオリジナル論文。 平成29年度 NGSハンズオン講習会 Hi-C解析…Hi-Cのデータ解析についてはこの資料がよくまとまっている。 RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell 2016…RIC-seq論文のなかで類似手法として比較されたPARISという方法の原著論文。 クライオ電子顕微鏡について AUC/ROC曲線 (三重大 奥村先生) 疾患におけるA-to-I RNA編集酵素ADAR1の役割 (生化学 2016年)…RNA編集についての詳しくてわかり易い日本語解説論文。 RNA Conformation Capture by Proximity Ligation. Annual Review of Genomics and Human Genetics 2020. Editorial notes 技術もさることながらその論文のストーリーがとてもよかった (soh) PUBG-seqとか出てこないかな (coela) Hi-Cはproximityをベースにはしているはずなのですが、実際の距離はわからないので、オリジナル論文に従ってcontact probabilityというべきだったなと思っております。ただcontactとは？？？ (tadasu)

In this episode, Dr’s J and Santhosh once again round up the latest in medical news focusing on the worldwide pandemic this time with a focus on the (mostly) postivie. Along the way, they cover coronavirus mascots, 60 days in quarantine, the best layperson personal protective equipement (ppe), viral sniffing dogs, the return of polio, a pediatric post covid syndrome, kawasaki disease, social distancing police drones, a possible treatment from llama antibodies, and more! So sit back and relax as we bring you whats new in the world of pandemic medicine!Sources1) https://www.zmescience.com/other/pieces/face-shield-coronavirus-01052020/2) https://www.zmescience.com/science/with-vaccination-suspended-niger-gets-hit-with-a-new-polio-outbreak/3) https://www.cell.com/cell/pdf/S0092-8674(20)30494-3.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420304943%3Fshowall%3Dtrue4) https://www.mentalfloss.com/article/623815/coronavirus-detecting-dogs?fbclid=IwAR1W3mocRV0x_LZyd_dVjnsY7hJXhyT8cizby9NVf0rtftdfFFaZNmZYefg5) https://gizmodo.com/police-deploy-pandemic-drone-to-detect-fevers-and-enfor-1843017443?utm_campaign=Gizmodo&utm_content=1587647241&utm_medium=SocialMarketing&utm_source=facebook&fbclid=IwAR2BfoVmnQa0FMh7vqH1UYtudFuCGGmOxqZN8iPvZjhOX-lWWvq96LvFUjYSupport Us spiritually, emotionally or financially here! Twitter: @doctorjcomedy @toshyfro Instagram: @travelmedicinepodcast Spotify: https://open.spotify.com/show/28uQe3cYGrTLhP6X0zyEhTFacebook: facebook.com/travelmedicinepodcast Squarespace: travelmedicinepodcast.squarespace.com Patreon: https://www.patreon.com/travelmedicinepodcast Gmail: travelmedicineinfo@gmail.com

Norepinephrine sends signals widely throughout the brain that move us into a task motivated stated. A brain regain called the locus coeruleus located in the brain stem is involved in the release of norepinephrine. As we shift to a more passive state, another type of brain cell called astrocytes take over (they get their name from their star shape). Astrocytes cells support neurons in the brain, and are the most abundant glial cells in the brain. A study by Yu Mu et al, 2019 (link below) with Zebra fish shows that Norepinephrine was released when they are moved to actively swim. Meanwhile, astrocyte activity increased when the fish moved to a passive state. When workers get tired, just like the Zebra fish who felt they were not getting anywhere with their swimming, a passive state sets in the brain. To overcome this passive state and increase Norepinephrine release into the brain, take a break or change up work pattern to increase productivity again. Other ways to increase task-engaged brain activity include getting early light exposure and exercising. Stay safe and healthy out there! For more on best investing strategies, avoiding bias and learning about your brain BUY 5 star reviewed “Understanding Behavioral Bia$” on Amazon - link here: http://amzn.to/2XHtsOE Links: Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior https://www.cell.com/cell/pdf/S0092-8674(19)30621-X.pdf Decision Fatigue Mental Models podcast…. Russell Foster book on sleep. https://www.amazon.com/Circadian-Rhythms-Short-Introduction-Introductions/dp/0198717687 Video of Dr. Daniel Krawczyk and George Baxter on ETFguide Which Behavioral Traits are Hurting Your Investment Results? https://youtu.be/34VnOUyNgcA Investors are often their own worst enemies. That's what investing great Ben Graham once concluded. In this episode, Lynn Dolan @ETFguide TV talks with Authors Daniel C. Krawczyk and George H. Baxter, JD, CFA about their new book Understanding Behavior BIA$: A Guide to Improving Financial Decision Making. Both men also host the Mental Models Podcast. https://youtu.be/34VnOUyNgcA Other resources for ETFguide TV viewers: 1. Free ETF Guides https://tinyurl.com/y2gep5kj 2. Habits of the Investing Greats https://tinyurl.com/y6cg9n4v 3. Index Investing Show https://tinyurl.com/y3862uaa

Mammals pretty much have the market cornered on hair, and you know all the other types of animals are jealous of us. Imagine a little lizard with bangs or something? It just wouldn’t be right. Sorry!   Follow us on Twitter @SciShowTangents, where we’ll tweet out topics for upcoming episodes and you can ask the science couch questions!    While you're at it, check out the Tangents crew on Twitter: Stefan: @itsmestefanchin Ceri: @ceriley Sam: @slamschultz Hank: @hankgreen   If you want to learn more about any of our main topics, check out these links:   [Truth or Fail]   Camarillo white horse https://books.google.com/books?id=WyYDAAAAMBAJ&pg=RA1-PA216&lpg=RA1-PA216&dq=%22telescopic+sight%22+spider+silk#v=onepage&q=%22telescopic%20sight%22%20spider%20silk&f=false https://vgl.ucdavis.edu/services/horse/CamarilloWhite.php https://www.camarillowhitehorses.org/history_camarillo_white_horses.html   African crested rat https://royalsocietypublishing.org/doi/full/10.1098/rspb.2011.1169 https://www.sciencemag.org/news/2011/08/case-poisonous-rat https://www.livescience.com/15360-crested-rat-poison-hairs-kills.html   Malabar giant squirrel https://www.nationalgeographic.com/animals/2019/04/indian-giant-squirrels-colors-camouflage/ https://www.theguardian.com/environment/shortcuts/2017/jan/08/colour-changing-cats-warn-radioactive-waste-nuclear-plants-distant-descendants   [Fact Off]   Hyena poop hair preservation https://www.smithsonianmag.com/smart-news/257000-years-ago-a-hyena-ate-some-human-hair-and-probably-the-rest-of-the-person-too-419574/ https://www.sciencedirect.com/science/article/pii/S030544031300160X   Graphene hair dye https://www.eurekalert.org/pub_releases/2018-03/nu-gfn031218.php https://www.cell.com/chem/fulltext/S2451-9294(18)30082-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451929418300822%3Fshowall%3Dtrue   [Ask the Science Couch]   Grey hair www.scientificamerican.com/article/why-does-hair-turn-gray/ https://science.sciencemag.org/content/307/5710/720 https://www.cell.com/cell/fulltext/S0092-8674(05)00293-X? https://www.fasebj.org/doi/full/10.1096/fj.08-125435   Stress www.theguardian.com/science/2020/jan/22/stress-speeds-up-hair-greying-process-science-confirms https://www.nature.com/articles/s41586-020-1935-3 https://www.health.harvard.edu/blog/hair-turn-gray-2017091812226 [Butt One More Thing]   Trichobezoar  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083501/  

En este episodio nos pusimos a platicar con un muy buen amigo sobre los límites y la filosofía del humor.- https://www.patreon.com/herejeselpodcast -Ale Durán - https://twitter.com/FunkBob -- https://www.instagram.com/ale_duran_erana/ - Lola Montalvo- https://twitter.com/lola_montalvo - Bobby López- https://twitter.com/BobbyEsqvlz -- https://www.instagram.com/bobbyesqvlz/ - Episodios, conversaciones y demás referidos en este episodio:Bloque de Sarah SilvermanStand Up Subtitulado Sarah Silverman- Compilado Jesus is magic https://www.youtube.com/watch?v=W9_G-Kc7Vek&feature=youtu.be Why No Joke Subject is Off Limits (Making Sense with Sam Harris) https://www.youtube.com/watch?v=jCvaqHGUVugBibliografía:¡JA! LA CIENCIA DE CUANDO REIMOS Y POR QUESCOTT WEEMS. Editorial: TAURUS https://amzn.to/3f093NcRod A. Martin, Patricia Puhlik-Doris, Gwen Larsen, Jeanette Gray, Kelly Weir,Individual differences in uses of humor and their relation to psychological well-being: Development of the Humor Styles Questionnaire, Journal of Research in Personality, Volume 37, Issue 1, 2003, Pages 48-75, ISSN 0092-6566, https://doi.org/10.1016/S0092-6566(02)00534-2. http://www.sciencedirect.com/science/article/pii/S0092656602005342Ruch, W., & Heintz, S. (2016). The German Version of the Humor Styles Questionnaire: Psychometric Properties and Overlap With Other Styles of Humor. Europe's journal of psychology, 12(3), 434–455. https://doi.org/10.5964/ejop.v12i3.1116Frewen, P. A., Brinker, J., Martin, R. A., & Dozois, D. A. (2008). Humor styles and personality-vulnerability to depression, HUMOR, 21(2), 179-195. doi: https://doi.org/10.1515/HUMOR.2008.009Jeremy A. Yip, Rod A. Martin, Sense of humor, emotional intelligence, and social competence, Journal of Research in Personality, Volume 40, Issue 6, 2006, Pages 1202-1208, ISSN 0092-6566. https://doi.org/10.1016/j.jrp.2005.08.005Ruch Willibald, Heintz Sonja, Platt Tracey, Wagner Lisa, Proyer René T. (2018) Broadening Humor: Comic Styles Differentially Tap into Temperament, Character, and Ability. Frontiers in Psychology, 9, 6.ISSN 1664-1078, DOI 10.3389/fpsyg.2018.00006. https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00006/fullMartin, R. A. (2001). Humor, laughter, and physical health: Methodological issues and research findings. Psychological Bulletin, 127(4), 504–519. https://doi.org/10.1037/0033-2909.127.4.504Keele University. (2013, May 1). Humor styles and bullying in schools: Not a laughing matter. ScienceDaily. Retrieved April 26, 2020 from https://www.sciencedaily.com/releases/2013/05/130501090657.htmFunny… or Bullying? Comic jokes about female comic for being fat and having only one arm- Writen by Judy Carter -Posted Jul 04, 2015. https://www.psychologytoday.com/us/blog/stress-is-laughing-matter/201507/funny-or-bullying

De gevolgen van stress tijdens de zwangerschap (https://www.cell.com/cell/pdf/S0092-8674(20)30162-8.pdf) Bacteriën kunnen gedood worden door licht geactiveerde coating (https://www.nature.com/articles/s41467-020-15004-6) Luchtvervuiling is gevaarlijker dan roken (https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvaa025/5770885) Koffie zorgt voor beter probleemoplossend vermogen maar verhoogt de creativiteit niet. (https://www.sciencedirect.com/science/article/abs/pii/S1053810019303435?via%3Dihub) Herinneringen worden op geslagen als een sequentie van Neuron-activaties (https://science.sciencemag.org/content/367/6482/1131) Artificiële intelliogentie is gebruikt om nieuwe antibiotica te maken (https://www.cell.com/cell/fulltext/S0092-8674(20)30102-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420301021%3Fshowall%3Dtrue)

Heya folks, today's episode is about intermittent fasting, a new(ish) and increasingly popular way of trying to lose weight. Is it just a fad diet, or something more complicated? How does someone go about doing intermittent fasting and what does it do on a biological level (as far as we know)?As a note: Intermittent fasting involves changing how and when you eat, and therefore is a topic that can be sensitive for those who have eating disorders. If you are concerned about the topic, please feel free to skip the episode and/or contact help, like the free helpline of the National Eating Disorders Association: https://www.nationaleatingdisorders.org/help-support/contact-helpline.Also! Because this topic involves a diet that can impact your health, we want to again mention that this does not constitute medical advice and you should discuss the topic with your doctor first.This week's promo is for the Not Suitable for Adults podcast! Check them out on twitter: @Not4AdultsCast http://not4adultscast.podbean.com/References:https://www.nejm.org/doi/full/10.1056/NEJMra1905136https://www.mdpi.com/2072-6643/11/10/2442/htm https://www.annualreviews.org/doi/full/10.1146/annurev-nutr-071816-064634https://www.annualreviews.org/doi/full/10.1146/annurev-nutr-071816-064916https://www.ncbi.nlm.nih.gov/pubmed/18641044 https://www.ncbi.nlm.nih.gov/pubmed/16647374https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058473/https://www.annualreviews.org/doi/full/10.1146/annurev-pharmtox-010814-12434https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(18)30001-8https://link.springer.com/article/10.1007/s13105-018-0658-5https://www.sciencedirect.com/science/article/pii/S1550413117305041https://www.sciencedirect.com/science/article/pii/S089158490600801X?via%3Dihubhttps://www.sciencedirect.com/science/article/pii/S2211124716305769https://www.sciencedirect.com/science/article/abs/pii/S2211034818301421https://www.tandfonline.com/doi/abs/10.1080/030097401750065256https://www.nature.com/articles/cddis201414https://www.cell.com/fulltext/S0092-8674(11)01276-1https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1444https://www.nature.com/articles/s41467-019-09897-1https://www.frontiersin.org/articles/10.3389/fimmu.2019.01402/fullhttps://pubs.acs.org/doi/abs/10.1021/acs.jproteome.9b00090https://academic.oup.com/ajcn/article/102/2/464/4564588https://www.sciencedirect.com/science/article/pii/S0960982218304433

出芽酵母の染色体をゲノム工学の技術によって1本に連結させた論文とその周辺について話しました。Show notes Creating a functional single- chromosome yeast … n=16の染色体を持つ出芽酵母において、テロメアとセントロメアを除きながら染色体同士を結合させ、最終的に大きな1つの染色体にした論文。 A single circular chromosome yeast … 1本にした論文において、さらにテロメアを除いて結合させることにより巨大な環状染色体にした論文。 FISH analysis of the telomere sequences of bulldog ants (Myrmecia: Formicidae) … 当時遺伝研で研究されていた今井先生がFISHによって調べたキバハリアリの染色体研究。2n=2-84と大きな幅を持っていることがわかる。2n=4が祖先型なのではないかとの推測。 Chromosome engineering allows the efficient isolation of vertebrate neocentromeres … 現阪大、当時遺伝研の深川先生らが行ったネオセントロメアに関する研究の論文。 Gametogenesis in a male Indian muntjac x Chinese muntjac hybrid … 2n=6のIndian Muntjacと2n=46のChinese Muntjacが、Shanghai Western Suburb Zooで自然交配した結果、生まれた子供の睾丸における減数分裂の状態を調べた論文。 Transvection … Fukaya先生によるTransvectionに関する最新のレビュー。 Recombination, Pairing, and Synapsis of Homologs during Meiosis … Denise ZicklerとNancy Klecknerによる減数分裂期の染色体に関するレビュー。Fig2において本エピソードでも話したCrossover (CO) interferenceの説明、Fig4においてRabl構造や染色体interlockについての解説がある。 Recombination Proteins Mediate Meiotic Spatial Chromosome Organization and Pairing … Denise ZicklerらによるSordariaの減数分裂期におけるinterlockとその解消に関する論文。 Interference-mediated synaptonemal complex formation with embedded crossover designation … 染色体上におけるcrossover間の距離データを集めることで考えられたcrossover interferenceに対するbeam-film (BF) modelに関する論文。 Unleashing meiotic crossovers in hybrid plants … crossoverの数が一つの染色体上で1-3個しかできない原因に関係する遺伝子を植物で探索した論文。 隠蔽種(cryptic species) Editorial notes 今年もどうぞ宜しくお願いします。染色体にうるさいpodcastです。(soh) でかい怪獣がいる世界では分子生物学の予算いっぱい付きそう。(coela) ちょっとやりすぎました (tadasu)

2019年の収録したエピソードを振り返りつつ、今年3人が買ってよかったものについて話しました。Show notes 2019年買ってよかったものまとめ (researchat.fm) Optical Pooled Screens in Human Cells. Feldman et al Cell (2019)…CRISPR-Cas9による遺伝学スクリーニングの結果を光学系イメージング (In situ sequencing)により細胞に与えられた摂動と破壊された遺伝子の情報を読み出す技術。 Yeti Blue…Researchat.fmで3人とも使っている性能のよいUSBマイク。様々な指向性の切り替えなども簡単。 iPad Pro…coelaアンドsoh絶賛のiPadProとApple Pencil。 自作キーボードについて…エピソード10では、自作キーボードの魅力についてcoelaが話しました。 白金鉱業.FM GTMカイゼリン…coelaが今年最後に買った実質タダのフィギュア。 33. Rising…ep33でもアツくカイゼリンについてcoelaが話しております。 THREE CUP CLASSIC CHEMEX®…sohにそそのかされてtadasuも購入したケメックスのコーヒーサーバー。長い歴史があり、綺麗なフォルム、おすすめです。 【特集｜美味しいコーヒー】OYATSUYA SUNに教わる、美味しいコーヒー（その2）『ケメックスで淹れる』 ハリオ コーヒーケトル 0.8LHARIO V60 温度調整付きパワーケトル…温度調整が1度単位でできるハリオのコーヒーケトル。sohのおすすめです。 セラミックコーヒーミル・スケルトン…sohとtadasuも愛用するハリオの手挽きのミル。 ジョージ・フォアマン (メリカで食べよう ずかしめし)…tadasuおすすめの電動グリル。なんでも焼ける。 PrimeSTAR® GXL DNA Polymerase (Takara)…よく増える、10kb以上でも増える、tadasuとsohも超オススメのDNAポリメラーゼ。一家に一台は必須ですね。 耐熱性のPCR用DNAポリメラーゼについて…ep24でもDNAポリメラーゼについて紹介しました。 Turbo Competent E. coli (NEB)…sohがおすすめの成長が爆速の大腸菌の株。朝、形質転換すると夕方にはコロニーが生えてきて捗ります。 Editorial notes 俺たちの2019年はまだ終わらないッ (soh) 初めてのTwitch配信も行いましたが無事うまくいけてよかったです。Turbo!!!(tadasu) 配信・買ってよかったもの紹介など、やりたかったことが2019年内にできて良かったです！(coela)

Dziś czekają na Was trzy ciekawostki ze świata nauki: Nowe rysunki w Nazca: https://www.yamagata-u.ac.jp/en/information/info/20191115_01/ Bakterie zjadające CO2: https://www.cell.com/cell/fulltext/S0092-8674(19)31230-9 Puls płetwala błękitnego: http://bit.ly/36GYQAm Muzyka: Track: Scary Island Artist: Verified Picasso

A new study, conducted by MIT, explored how a ketogenic diet and exogenous ketones govern signaling biological programs that maintain intestinal stem cell function. We know ketone bodies like beta-hydroxybutyrate have signaling roles in the body and can help regulate things like appetite, metabolism, and neurotransmitter function. This study provides evidence that BHB itself may play a key mediating role in maintaining intestinal health too. Do ketones themselves (and not necessarily through fasting or a ketogenic diet) alone drive some of the metabolic and functional benefits? What were the exact findings? Let's find out. Study: https://www.cell.com/cell/fulltext/S0092-8674(19)30848-7 HVMN Ketone Ester: https://go.hvmn.com/ketone-pod ---------------------------------------------------------------------------- Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.

En este episodio, comentamos tres estudios muy propios de nuestros tiempos: uno sobre embriones de rata no que provienen de óvulos ni de espermatozoides (su origen te dejará boquiabierto), otro sobre el efecto de la pizza en la salud (!los resultados te sorprenderán!) y uno más sobre las generalizaciones en el lenguaje científico (¡no te lo puedes ni imaginar!). Acompáñennos porque este episodio tiene mucha carnita, que desmenuzamos poco a poco y de manera sabrosa (¡su sabor te dejará con anonadamiento!). Menú 00:20 - Inicio, saludos y recuentos 02:51 - Embriones sin padre ni madre (y su efecto en el desarrollo) 25:02 - Italianos comen pizza en Italia (y sus efectos en su salud) 43:24 - Títulos de estudios científicos con generalizaciones (y su efecto en la comunicación de la ciencia) Voces y contenido: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Producción: Víctor Hernández Edición: Víctor Hernández Voz en la rúbrica: Valeria Sánchez Este podcast es producido desde una ciudad donde hay mucha pizza, aunque seguro que a los italianos les resultaría difícil llamarle pizza. Fuentes y lecturas recomendadas El estudio de los embriones (en inglés): https://www.cell.com/cell/fulltext/S0092-8674(19)31080-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419310803%3Fshowall%3Dtrue El primer estudio sobre la pizza y su relación con los infartos: https://www.nature.com/articles/1601997 Y su anuncio en los premios Ignobel:https://www.improbable.com/2019/09/12/announcing-the-2019-ig-nobel-prize-winners/ El estudio de las generalizaciones en el lenguaje científico (en inglés): https://www.pnas.org/content/116/37/18370 Música y audios "That's amore", de Dean Martin "Que viva mi general", con Óscar Chávez y el Piporro "Huérfano soy", de Trio La Rosa Intro y salida: Little Lily Swing, de Tri-Tachyon, bajo una licencia Creative Commons 3.0 de Atribución: freemusicarchive.org/music/Tri-Tachyon/ Rúbrica: Now son, de Podington Bear, freemusicarchive.org/music/Podington_Bear/ Bajo una licencia Creative Commons Internacional de Atribución No Comercial 3.0 Eggs! Toast! Gas! Fish! by Elvis Herod is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Episode Summary:Dr. Dan discusses what is actually known in the scientific literature regarding the keto diet.Episode References:The keto diet in the treatment of drug resistant epilepsy: https://www.ncbi.nlm.nih.gov/pubmed/31204451See here for a good review on the science of the ketones diet: https://www.nature.com/articles/ejcn2013116Keto diet can change composition of the microbiome: https://www.cell.com/cell/fulltext/S0092-8674(18)30520-8The keto diet changes levels of microRNA: https://www.ncbi.nlm.nih.gov/pubmed/30474543There could be health issues with eating pattern too low in carbohydrates: https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30135-X/fulltext

Living things are so full of complicated systems of cells and DNA, that things are bound to go wrong. And sometimes when things go wrong, cancer is the result. Today on Tangents we talk about the causes, health impacts, and potential cures (both real and fake) of cancer.    [Truth or Fail]   Norman Baker https://historycollection.co/norman-baker-man-claimed-cure-cancer/   Cow War https://lib.dr.iastate.edu/cgi/viewcontent.cgi?referer=https://www.google.com/&httpsredir=1&article=3298&context=iowastate_veterinarian   Animal Testes Transplant https://www.vice.com/en_us/article/4x3p73/early-body-hacking-when-men-got-goat-testicle-grafts-to-boost-their-sex-drive   The Philosophy of Success Book https://archive.org/details/Law_Of_Success_in_16_Lessons   [Fact Off]   Turtle fossil bone cancer: https://www.nationalgeographic.com/science/2019/02/ridiculously-rare-cancer-found-fossil-leg-turtle-triassic-paleontology/ https://jamanetwork.com/journals/jamaoncology/article-abstract/2723578   Parasite-human cancer transmission: https://www.cdc.gov/media/releases/2015/p1104-parasite-tumors.html https://www.scientificamerican.com/article/tapeworm-spreads-deadly-cancer-to-human/ https://www.sciencedaily.com/releases/2019/03/190325110313.htm   [Ask the Science Couch]   General: https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/hpv-and-cancer https://www.popsci.com/transmissible-cancers-animals/   Tasmanian devil: https://www.tcg.vet.cam.ac.uk/about/DFTD https://www.nature.com/articles/onc2009350 https://elifesciences.org/articles/35314   Clams: https://www.cell.com/cell/fulltext/S0092-8674(15)00243-3  https://www.nature.com/articles/nature18599   [Butt One More Thing]   Farts & cancer: https://time.com/2976464/scientists-say-smelling-farts-might-prevent-cancer/ https://pubs.rsc.org/En/content/articlelanding/2014/md/c3md00323j#!divAbstract  

This episode begins our discussion of the prehistory of Homo sapiens, the species to which we belong. Our origins are examined on the African continent and we trace the movement of our Ancestors across the world, from Asia to Australia, and from Europe and Siberia to the Americas. This episode ends with a discussion of race, how it developed as a concept, and what it means to anthropologists today.Transcript: https://riverofhistory.tumblr.com/post/183673468776/episode-9-homo-sapiensLinks and Referenced Mentioned:Inspiration for the dissection of‘population’ and ‘migration’: https://blogs.scientificamerican.com/observations/plug-and-play-genetics-racial-migrations-and-human-history/Steve Olson quote: Mapping Human History, Mariner Books(2002)African Multiregionalism: https://www.sciencedirect.com/science/article/pii/S0959437X1730182X?dgcid=authorBorrowing of the term “Ancestor”: The Humans Who Went Extinct, CliveFinlayson, Oxford University Press (2009)Generalist Specialists:https://www.researchgate.net/publication/326689995_Defining_the_'generalist_specialist'_niche_for_Pleistocene_Homo_sapiens_Nature_Human_BehaviourDeep Ancestral Ties to LivingAfricans: https://www.nature.com/articles/d41586-018-07164-9& https://www.sciencedirect.com/science/article/pii/S0959437X18300601?via%3DihubOldest Bow-and-Arrow: https://www.researchgate.net/publication/324721964_The_antiquity_of_bow-and-arrow_technology_Evidence_from_Middle_Stone_Age_layers_at_Sibudu_CaveAccess of Southwest Asia fromAfrica via warm and wet corridors:https://www.researchgate.net/publication/303763801_Palaeohydrological_corridors_for_hominin_dispersals_in_the_Middle_East_250-70000_years_agoReturn movements into Africa:https://www.researchgate.net/publication/325856764_Carriers_of_mitochondrial_DNA_macrohaplogroup_L3_basal_lineages_migrated_back_to_Africa_from_Asia_around_70000_years_ago1.5-2.1% of non-African genomes areNeanderthal: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/Neanderthal Traits in Homo sapiens: https://ghr.nlm.nih.gov/primer/dtcgenetictesting/neanderthaldna &https://www.ncbi.nlm.nih.gov/pubmed/28985494Early Homo sapiens movements into Eurasia:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164938/& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933530/& https://www.nature.com/articles/s41559-017-0436-8 & https://www.nature.com/articles/s41598-019-38818-xToba Eruption Discussion: When Humans Nearly Vanished, DonaldProthero, Smithsonian Books (2018) & TheGreat Divide, Peter Watson, HarperCollins Publishers (2013)Possible climate-driver for Humansleaving Africa: https://pubs.geoscienceworld.org/gsa/geology/article/45/11/1023/516677/a-climatic-context-for-the-out-of-africa-migrationLice study and the Origin ofClothing: https://www.cell.com/current-biology/fulltext/S0960-9822(03)00507-4?Bone needles: https://www.sapiens.org/archaeology/fashion-history-sewing-needles/Alexander Harcourt coastalmigration reference: Humankind,Pegasus Books (2015)Genetic evidence for peopling ofSoutheast Asia: http://science.sciencemag.org/content/361/6397/88.longPeopling of Sahul: https://www.sciencedirect.com/science/article/pii/S0047248418302136 &https://www.nature.com/articles/nature18299& https://www.nature.com/articles/nature21416Peopling of Eastern & Northern Asia:https://investigativegenetics.biomedcentral.com/articles/10.1186/2041-2223-4-11 &http://www.genetics.org/content/202/1/261 & http://advances.sciencemag.org/content/3/2/e1601877.fullMating between Denisovans andAncestors: https://peerj.com/preprints/27526.pdfPeopling of Europe: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752585/ &https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427117/& https://www.newscientist.com/article/2139694-we-may-have-mated-with-neanderthals-more-than-219000-years-ago/ &https://www.nature.com/articles/s41598-019-41033-3Peopling of Siberia: https://www.journals.uchicago.edu/doi/full/10.1086/693388Peopling of the Americas: https://www.ncbi.nlm.nih.gov/pubmed/27507099 &http://advances.sciencemag.org/content/4/8/eaat5473& https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0030185 &https://www.nationalgeographic.com/science/2018/11/ancient-dna-reveals-complex-migrations-first-americans/ &https://www.cell.com/current-biology/fulltext/S0960-9822(18)31495-7?Discussion of Race: A Brief History of Everyone Who Ever Lived,Adam Rutherford, The Experiment (2017); MappingHuman History, Steve Olson, Mariner Books (2002); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756148/Development of Phenotypic Traits: http://science.sciencemag.org/content/358/6365/eaan8433 &https://www.cell.com/abstract/S0092-8674%2813%2900067-6

This episode begins our discussion of the prehistory of Homo sapiens, the species to which we belong. Our origins are examined on the African continent and we trace the movement of our Ancestors across the world, from Asia to Australia, and from Europe and Siberia to the Americas. This episode ends with a discussion of race, how it developed as a concept, and what it means to anthropologists today.Transcript: https://riverofhistory.tumblr.com/post/183673468776/episode-9-homo-sapiensLinks and Referenced Mentioned:Inspiration for the dissection of ‘population’ and ‘migration’: https://blogs.scientificamerican.com/observations/plug-and-play-genetics-racial-migrations-and-human-history/Steve Olson quote: Mapping Human History, Mariner Books (2002)African Multiregionalism: https://www.sciencedirect.com/science/article/pii/S0959437X1730182X?dgcid=authorBorrowing of the term “Ancestor”: The Humans Who Went Extinct, Clive Finlayson, Oxford University Press (2009)Generalist Specialists: https://www.researchgate.net/publication/326689995_Defining_the_'generalist_specialist'_niche_for_Pleistocene_Homo_sapiens_Nature_Human_BehaviourDeep Ancestral Ties to Living Africans: https://www.nature.com/articles/d41586-018-07164-9 & https://www.sciencedirect.com/science/article/pii/S0959437X18300601?via%3DihubOldest Bow-and-Arrow: https://www.researchgate.net/publication/324721964_The_antiquity_of_bow-and-arrow_technology_Evidence_from_Middle_Stone_Age_layers_at_Sibudu_CaveAccess of Southwest Asia from Africa via warm and wet corridors: https://www.researchgate.net/publication/303763801_Palaeohydrological_corridors_for_hominin_dispersals_in_the_Middle_East_250-70000_years_agoReturn movements into Africa: https://www.researchgate.net/publication/325856764_Carriers_of_mitochondrial_DNA_macrohaplogroup_L3_basal_lineages_migrated_back_to_Africa_from_Asia_around_70000_years_ago1.5-2.1% of non-African genomes are Neanderthal: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/Neanderthal Traits in Homo sapiens: https://ghr.nlm.nih.gov/primer/dtcgenetictesting/neanderthaldna & https://www.ncbi.nlm.nih.gov/pubmed/28985494Early Homo sapiens movements into Eurasia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164938/& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933530/ & https://www.nature.com/articles/s41559-017-0436-8 & https://www.nature.com/articles/s41598-019-38818-xToba Eruption Discussion: When Humans Nearly Vanished, Donald Prothero, Smithsonian Books (2018) & The Great Divide, Peter Watson, HarperCollins Publishers (2013)Possible climate-driver for Humans leaving Africa: https://pubs.geoscienceworld.org/gsa/geology/article/45/11/1023/516677/a-climatic-context-for-the-out-of-africa-migrationLice study and the Origin of Clothing: https://www.cell.com/current-biology/fulltext/S0960-9822(03)00507-4?Bone needles: https://www.sapiens.org/archaeology/fashion-history-sewing-needles/Alexander Harcourt coastal migration reference: Humankind, Pegasus Books (2015)Genetic evidence for peopling of Southeast Asia: http://science.sciencemag.org/content/361/6397/88.longPeopling of Sahul: https://www.sciencedirect.com/science/article/pii/S0047248418302136 & https://www.nature.com/articles/nature18299 & https://www.nature.com/articles/nature21416Peopling of Eastern & Northern Asia: https://investigativegenetics.biomedcentral.com/articles/10.1186/2041-2223-4-11 & http://www.genetics.org/content/202/1/261 & http://advances.sciencemag.org/content/3/2/e1601877.fullMating between Denisovans and Ancestors: https://peerj.com/preprints/27526.pdfPeopling of Europe: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752585/ & https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427117/ & https://www.newscientist.com/article/2139694-we-may-have-mated-with-neanderthals-more-than-219000-years-ago/ & https://www.nature.com/articles/s41598-019-41033-3Peopling of Siberia: https://www.journals.uchicago.edu/doi/full/10.1086/693388Peopling of the Americas: https://www.ncbi.nlm.nih.gov/pubmed/27507099 & http://advances.sciencemag.org/content/4/8/eaat5473 & https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0030185 & https://www.nationalgeographic.com/science/2018/11/ancient-dna-reveals-complex-migrations-first-americans/ & https://www.cell.com/current-biology/fulltext/S0960-9822(18)31495-7?Discussion of Race: A Brief History of Everyone Who Ever Lived, Adam Rutherford, The Experiment (2017); Mapping Human History, Steve Olson, Mariner Books (2002); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756148/ Development of Phenotypic Traits: http://science.sciencemag.org/content/358/6365/eaan8433 & https://www.cell.com/abstract/S0092-8674%2813%2900067-6

This episode begins our discussion of the prehistory of Homo sapiens, the species to which we belong. Our origins are examined on the African continent and we trace the movement of our Ancestors across the world, from Asia to Australia, and from Europe and Siberia to the Americas. This episode ends with a discussion of race, how it developed as a concept, and what it means to anthropologists today.Transcript: https://riverofhistory.tumblr.com/post/183673468776/episode-9-homo-sapiensLinks and Referenced Mentioned:Inspiration for the dissection of ‘population’ and ‘migration’: https://blogs.scientificamerican.com/observations/plug-and-play-genetics-racial-migrations-and-human-history/Steve Olson quote: Mapping Human History, Mariner Books (2002)African Multiregionalism: https://www.sciencedirect.com/science/article/pii/S0959437X1730182X?dgcid=authorBorrowing of the term “Ancestor”: The Humans Who Went Extinct, Clive Finlayson, Oxford University Press (2009)Generalist Specialists: https://www.researchgate.net/publication/326689995_Defining_the_'generalist_specialist'_niche_for_Pleistocene_Homo_sapiens_Nature_Human_BehaviourDeep Ancestral Ties to Living Africans: https://www.nature.com/articles/d41586-018-07164-9 & https://www.sciencedirect.com/science/article/pii/S0959437X18300601?via%3DihubOldest Bow-and-Arrow: https://www.researchgate.net/publication/324721964_The_antiquity_of_bow-and-arrow_technology_Evidence_from_Middle_Stone_Age_layers_at_Sibudu_CaveAccess of Southwest Asia from Africa via warm and wet corridors: https://www.researchgate.net/publication/303763801_Palaeohydrological_corridors_for_hominin_dispersals_in_the_Middle_East_250-70000_years_agoReturn movements into Africa: https://www.researchgate.net/publication/325856764_Carriers_of_mitochondrial_DNA_macrohaplogroup_L3_basal_lineages_migrated_back_to_Africa_from_Asia_around_70000_years_ago1.5-2.1% of non-African genomes are Neanderthal: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/Neanderthal Traits in Homo sapiens: https://ghr.nlm.nih.gov/primer/dtcgenetictesting/neanderthaldna & https://www.ncbi.nlm.nih.gov/pubmed/28985494Early Homo sapiens movements into Eurasia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164938/& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933530/ & https://www.nature.com/articles/s41559-017-0436-8 & https://www.nature.com/articles/s41598-019-38818-xToba Eruption Discussion: When Humans Nearly Vanished, Donald Prothero, Smithsonian Books (2018) & The Great Divide, Peter Watson, HarperCollins Publishers (2013)Possible climate-driver for Humans leaving Africa: https://pubs.geoscienceworld.org/gsa/geology/article/45/11/1023/516677/a-climatic-context-for-the-out-of-africa-migrationLice study and the Origin of Clothing: https://www.cell.com/current-biology/fulltext/S0960-9822(03)00507-4?Bone needles: https://www.sapiens.org/archaeology/fashion-history-sewing-needles/Alexander Harcourt coastal migration reference: Humankind, Pegasus Books (2015)Genetic evidence for peopling of Southeast Asia: http://science.sciencemag.org/content/361/6397/88.longPeopling of Sahul: https://www.sciencedirect.com/science/article/pii/S0047248418302136 & https://www.nature.com/articles/nature18299 & https://www.nature.com/articles/nature21416Peopling of Eastern & Northern Asia: https://investigativegenetics.biomedcentral.com/articles/10.1186/2041-2223-4-11 & http://www.genetics.org/content/202/1/261 & http://advances.sciencemag.org/content/3/2/e1601877.fullMating between Denisovans and Ancestors: https://peerj.com/preprints/27526.pdfPeopling of Europe: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752585/ & https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427117/ & https://www.newscientist.com/article/2139694-we-may-have-mated-with-neanderthals-more-than-219000-years-ago/ & https://www.nature.com/articles/s41598-019-41033-3Peopling of Siberia: https://www.journals.uchicago.edu/doi/full/10.1086/693388Peopling of the Americas: https://www.ncbi.nlm.nih.gov/pubmed/27507099 & http://advances.sciencemag.org/content/4/8/eaat5473 & https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0030185 & https://www.nationalgeographic.com/science/2018/11/ancient-dna-reveals-complex-migrations-first-americans/ & https://www.cell.com/current-biology/fulltext/S0960-9822(18)31495-7?Discussion of Race: A Brief History of Everyone Who Ever Lived, Adam Rutherford, The Experiment (2017); Mapping Human History, Steve Olson, Mariner Books (2002); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756148/ Development of Phenotypic Traits: http://science.sciencemag.org/content/358/6365/eaan8433 & https://www.cell.com/abstract/S0092-8674%2813%2900067-6

This episode begins our discussion of the prehistory of Homo sapiens, the species to which we belong. Our origins are examined on the African continent and we trace the movement of our Ancestors across the world, from Asia to Australia, and from Europe and Siberia to the Americas. This episode ends with a discussion of race, how it developed as a concept, and what it means to anthropologists today.Transcript: https://riverofhistory.tumblr.com/post/183673468776/episode-9-homo-sapiensLinks and Referenced Mentioned:Inspiration for the dissection of‘population’ and ‘migration’: https://blogs.scientificamerican.com/observations/plug-and-play-genetics-racial-migrations-and-human-history/Steve Olson quote: Mapping Human History, Mariner Books(2002)African Multiregionalism: https://www.sciencedirect.com/science/article/pii/S0959437X1730182X?dgcid=authorBorrowing of the term “Ancestor”: The Humans Who Went Extinct, CliveFinlayson, Oxford University Press (2009)Generalist Specialists:https://www.researchgate.net/publication/326689995_Defining_the_'generalist_specialist'_niche_for_Pleistocene_Homo_sapiens_Nature_Human_BehaviourDeep Ancestral Ties to LivingAfricans: https://www.nature.com/articles/d41586-018-07164-9& https://www.sciencedirect.com/science/article/pii/S0959437X18300601?via%3DihubOldest Bow-and-Arrow: https://www.researchgate.net/publication/324721964_The_antiquity_of_bow-and-arrow_technology_Evidence_from_Middle_Stone_Age_layers_at_Sibudu_CaveAccess of Southwest Asia fromAfrica via warm and wet corridors:https://www.researchgate.net/publication/303763801_Palaeohydrological_corridors_for_hominin_dispersals_in_the_Middle_East_250-70000_years_agoReturn movements into Africa:https://www.researchgate.net/publication/325856764_Carriers_of_mitochondrial_DNA_macrohaplogroup_L3_basal_lineages_migrated_back_to_Africa_from_Asia_around_70000_years_ago1.5-2.1% of non-African genomes areNeanderthal: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031459/Neanderthal Traits in Homo sapiens: https://ghr.nlm.nih.gov/primer/dtcgenetictesting/neanderthaldna &https://www.ncbi.nlm.nih.gov/pubmed/28985494Early Homo sapiens movements into Eurasia:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164938/& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933530/& https://www.nature.com/articles/s41559-017-0436-8 & https://www.nature.com/articles/s41598-019-38818-xToba Eruption Discussion: When Humans Nearly Vanished, DonaldProthero, Smithsonian Books (2018) & TheGreat Divide, Peter Watson, HarperCollins Publishers (2013)Possible climate-driver for Humansleaving Africa: https://pubs.geoscienceworld.org/gsa/geology/article/45/11/1023/516677/a-climatic-context-for-the-out-of-africa-migrationLice study and the Origin ofClothing: https://www.cell.com/current-biology/fulltext/S0960-9822(03)00507-4?Bone needles: https://www.sapiens.org/archaeology/fashion-history-sewing-needles/Alexander Harcourt coastalmigration reference: Humankind,Pegasus Books (2015)Genetic evidence for peopling ofSoutheast Asia: http://science.sciencemag.org/content/361/6397/88.longPeopling of Sahul: https://www.sciencedirect.com/science/article/pii/S0047248418302136 &https://www.nature.com/articles/nature18299& https://www.nature.com/articles/nature21416Peopling of Eastern & Northern Asia:https://investigativegenetics.biomedcentral.com/articles/10.1186/2041-2223-4-11 &http://www.genetics.org/content/202/1/261 & http://advances.sciencemag.org/content/3/2/e1601877.fullMating between Denisovans andAncestors: https://peerj.com/preprints/27526.pdfPeopling of Europe: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752585/ &https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427117/& https://www.newscientist.com/article/2139694-we-may-have-mated-with-neanderthals-more-than-219000-years-ago/ &https://www.nature.com/articles/s41598-019-41033-3Peopling of Siberia: https://www.journals.uchicago.edu/doi/full/10.1086/693388Peopling of the Americas: https://www.ncbi.nlm.nih.gov/pubmed/27507099 &http://advances.sciencemag.org/content/4/8/eaat5473& https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0030185 &https://www.nationalgeographic.com/science/2018/11/ancient-dna-reveals-complex-migrations-first-americans/ &https://www.cell.com/current-biology/fulltext/S0960-9822(18)31495-7?Discussion of Race: A Brief History of Everyone Who Ever Lived,Adam Rutherford, The Experiment (2017); MappingHuman History, Steve Olson, Mariner Books (2002); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756148/Development of Phenotypic Traits: http://science.sciencemag.org/content/358/6365/eaan8433 &https://www.cell.com/abstract/S0092-8674%2813%2900067-6

Preparándonos para el buen tiempo en el hemisferio norte, hoy os traigo un tema que va a promocionar mis pesadillas: los mosquitos. Os hablo de los mosquitos porque se ha publicado un artículo sobre cómo ponerlos a dieta, y de paso os cuento un poco sobre su vida y la mía, que está llena de odio hacia ellos. Aprovecho además para recordaros que hay insectos que merecen vivir, que los insectos son vuestros amigos, y para ello os recomiendo una película que, al igual que este podcast, es para todos los públicos. Si queréis leer el artículo sobre los mosquitos lo podéis hacer aquí: https://www.cell.com/cell/pdf/S0092-8674(18)31587-3.pdfSi lo que queréis es ver la película lo podéis hacer en Netflix: https://www.netflix.com/title/70060010 o buscarla en vuestra plataforma favorita.Para cualquier duda o comentario, las formas de contactar conmigo son a través de Twitter @karmegd o por email a karmegd@gmail.com. Y no olvides pasarte por https://www.instagram.com/karmegd para ver las fotos que acompañan a este capítulo y por https://emilcarfm.singularshirts.com/ para comprar la camiseta del podcast. También esperamos tus comentarios en emilcar.fm/bacteriofagos y en nuestro grupo de Telegram https://t.me/Bacteriofagos, en el que discutimos muchos temas relacionados (o no) con la ciencia.

Preparándonos para el buen tiempo en el hemisferio norte, hoy os traigo un tema que va a promocionar mis pesadillas: los mosquitos. Os hablo de los mosquitos porque se ha publicado un artículo sobre cómo ponerlos a dieta, y de paso os cuento un poco sobre su vida y la mía, que está llena de odio hacia ellos. Aprovecho además para recordaros que hay insectos que merecen vivir, que los insectos son vuestros amigos, y para ello os recomiendo una película que, al igual que este podcast, es para todos los públicos. Si queréis leer el artículo sobre los mosquitos lo podéis hacer aquí: https://www.cell.com/cell/pdf/S0092-8674(18)31587-3.pdfSi lo que queréis es ver la película lo podéis hacer en Netflix: https://www.netflix.com/title/70060010 o buscarla en vuestra plataforma favorita.Para cualquier duda o comentario, las formas de contactar conmigo son a través de Twitter @karmegd o por email a karmegd@gmail.com. Y no olvides pasarte por https://www.instagram.com/karmegd para ver las fotos que acompañan a este capítulo y por https://emilcarfm.singularshirts.com/ para comprar la camiseta del podcast. También esperamos tus comentarios en emilcar.fm/bacteriofagos y en nuestro grupo de Telegram https://t.me/Bacteriofagos, en el que discutimos muchos temas relacionados (o no) con la ciencia.

In dieser Podcast-Folge spricht Prof. Dr. med. Harald Schmidt zum zweiten Mal mit dem Geschäftsführer / Managing Director, CEO & Gründer der BIOMES NGS GmbH, Dr. rer. nat. Paul Hammer, über die Optimierung des Mikrobioms, Behandlung und Risiken. Überraschende Erkenntnisse und direkte praktische Impulse warten auf Sie. //   Interview-Gast: Dr. rer. nat. Paul Hammer, Geschäftsführer / Managing Director, CEO & Founder, BIOMES NGS GmbH, Freiheitstraße 124, 15745 Wildau - Germany, phone: +49 (0) 3375 585 62 41, mobile: +49 (0) 163 47 41 531, paul.hammer@BIOMES.world www.BIOMES.world, LinkedIn: https://www.linkedin.com/company/biomes.world, Facebook: https://www.facebook.com/BIOMES.world, Instagram: https://www.instagram.com/we.are.biomes/ //   Das Mikrobiom auf Wikipedia: https://de.wikipedia.org/wiki/Mikrobiom //   Dokumentation auf arte „Der kluge Bauch, Unser zweites Gehirn“. Ab ca. der Hälfte geht es auch um das Mikrobiom: https://tinyurl.com/y8mabxua //   Das Mikrobiom: Entscheidender Faktor für die Personalisierte Medizin der Zukunft: https://www.roche.de/res/literatur/984/Das-Mikrobiom-Entscheidender-Faktor-fuer-die-Personalisierte-Medizin-der-Zukunft-original-752ed7452522c1027df3de3c2d2e5299.pdf //   ÄrzteZeitung “Bakterien und Viren sind viel mehr als Untermieter”: https://www.aerztezeitung.de/medizin/krankheiten/infektionskrankheiten/article/933326/mikrobiom-darm-bakterien-viren-untermieter.html //   Mikrobiom und Verhalten in “Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders”: https://www.cell.com/cell/fulltext/S0092-8674(13)01473-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867413014736%3Fshowall%3Dtrue //   Das Europäische Metagenomics of the Human Intestinal Tract (MetaHIT)-Konsortium: http://www.metahit.eu/ //   Hierzu auch “A human gut microbial gene catalogue established by metagenomic sequencing”: https://www.nature.com/articles/nature08821 //   Das Menschliche-Mikrobiom-Projekt (USA, englisch): http://commonfund.nih.gov/hmp //   Schwerpunktprogramm der Deutschen Forschungs- gemeinschaft (SPP1656): www.intestinal-microbiota.de //   Krankheitsbedeutung des Mikrobioms: Parkinson https://www.cell.com/cell/fulltext/S0092-8674(16)31590-2; Psyche https://www.nature.com/articles/mp201650; Bluthochdruck http://www.pnas.org/content/110/11/4410.full; Diabetes https://www.aerzteblatt.de/archiv/177992/Das-Mikrobiom-Einfluss-auf-Adipositas-und-Diabetes //   Nebenwirkung einer Antibiotika-Behandlung: https://www.aerztezeitung.de/medizin/krankheiten/infektionskrankheiten/magen-darminfekte/article/976036/mikrobiom-antibiotika-veraendern-darmflora.html https://link.springer.com/article/10.1007/s11298-018-6489-4 https://www.aerzteblatt.de/nachrichten/68130/Wie-Antibiotika-die-fruehkindliche-Entwicklung-des-Mikrobioms-beeinflussen //   Mikrobiom-Therapie: Ernährung https://www.aerzteblatt.de/archiv/177992/Das-Mikrobiom-Einfluss-auf-Adipositas-und-Diabetes; Stuhl-Transplantation https://de.wikipedia.org/wiki/Stuhltransplantation, https://www.aerzteblatt.de/archiv/134461/Stuhltransplantation-bei-therapierefraktaerer-Clostridium-difficile-assoziierter-Kolitis; Probiotika https://biomes.world/shop/ //   Heutiger Pharmasong: Interpret: Lambchop, Album: Is A Woman, Titel: Bugs, Zitat: [Bugs rub their legs together in a fevered pitch...] //   Kontakt/Feedback: LinkedIn: https://nl.linkedin.com/in/haraldschmidt; Twitter: @hhhw_schmidt; Facebook: harald.hhw.schmidt; Xing: Harald_Schmidt303; Instagram: hhhw_schmidt; Email: harald.schmidt@gesundheithoch3.de Folge direkt herunterladen

In dieser Podcastfolge zum Thema Mikrobiom spricht Harald Schmidt mit Dr. rer. nat. Paul Hammer (Geschäftsführer/Managing Director, CEO & Gründer der BIOMES NGS GmbH, Freiheitstraße 124, 15745 Wildau, Tel. (03375) 5856241, Mobil (0163) 4741531, Email paul.hammer@biomes.world, www.biomes.world, sowie auf LinkedIn: https://www.linkedin.com/company/biomes.world, Facebook: https://www.facebook.com/BIOMES.worldm, Instagram: https://www.instagram.com/we.are.biomes) über die spannenden Entdeckungen zu unserem Mikrobiom. Interessante Neuigkeiten und Impulse warten auf Sie.  Das Mikrobiom auf Wikipedia: https://de.wikipedia.org/wiki/Mikrobiom, ein Dokumentation auf arte „Der kluge Bauch, Unser zweites Gehirn“. Ab ca. der Hälfte geht es auch um das Mikrobiom: https://tinyurl.com/y8mabxua.  Das Mikrobiom ist ein entscheidender Faktor für die Personalisierte Medizin der Zukunft: https://www.roche.de/res/literatur/984/Das-Mikrobiom-Entscheidender-Faktor-fuer-die-Personalisierte-Medizin-der-Zukunft-original-752ed7452522c1027df3de3c2d2e5299.pdf.  Die ÄrzteZeitung zum Thema “Bakterien und Viren sind viel mehr als Untermieter”: https://www.aerztezeitung.de/medizin/krankheiten/infektionskrankheiten/article/933326/mikrobiom-darm-bakterien-viren-untermieter.html.  Das Mikrobiom und und unser Verhalten in “Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders”: https://www.cell.com/cell/fulltext/S0092-8674(13)01473-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867413014736%3Fshowall%3Dtrue.  Das Europäische Metagenomics of the Human Intestinal Tract (MetaHIT)-Konsortium: http://www.metahit.eu/; Hierzu auch “A human gut microbial gene catalogue established by metagenomic sequencing”: https://www.nature.com/articles/nature08821.  Das Menschliche-Mikrobiom-Projekt (USA, englisch): http://commonfund.nih.gov/hmp. Ein Schwerpunktprogramm der Deutschen Forschungsgemeinschaft (SPP1656) zum Mikrofilm: www.intestinal-microbiota.de.  Der heutige Pharma-Song ist von Patrick James aus dem Album "Outlier" und trägt den Titel "Bugs". Das Zitat "...bugs are getting in between my ears and they’re crawling on my face.." Wer mich kontaktieren möchte oder Anregungen hat kann dies gerne tun und zwar über LinkedIn: https://nl.linkedin.com/in/haraldschmidt, Twitter: @hhhw_schmidt, Facebook: harald.hhw.schmidt, Xing: Harald_Schmidt303, Instagram: hhhw_schmidt, Email: harald.schmidt@gesundheithoch3.de. Folge direkt herunterladen

Welcome to the October episode of 3-Minute 3Rs, brought to you by Lab Animal (www.nature.com/laban, the NC3Rs (www.nc3rs.org.uk) & the North American 3Rs Collaborative (www.na3rsc.org) Here are the papers behind the pod: 1. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. https://www.cell.com/cell/fulltext/S0092-8674(18)30903-6 2. Mymou: A low-cost, wireless touchscreen system for automated training of nonhuman primates. https://link.springer.com/article/10.3758%2Fs13428-018-1109-5 3. Practical rat tickling: Determining an efficient and effective dosage of heterospecific play. https://www.appliedanimalbehaviour.com/article/S0168-1591(18)30255-7/fulltext Transcript: [LA] Organoids are three-dimensional tissue cultures that resemble more complicated structures. They're promising alternatives to animal models for studying diseases and for testing potential treatments. But tissues grown in a dish lack an immune system. That's a critical component for predicting how something will function in a living organism. To add some immunity to their organoids, Emile Voest from the Netherlands Cancer Institute and his colleagues recently developed a new co-culturing platform. In their latest work, published in the journal Cell in September, they culture epithelial organoids, derived from human cancer patients, along with blood from those same patients. The co-culturing platform allowed the researchers to study how T-cells from the patients' immune systems interacted with the organoids, attacking cancerous cells while ignoring healthy ones. It's a personal approach for understanding immunotherapy, no animals required. [NA3RsC] We all strive to provide laboratory animals with positive welfare, but it's difficult to actually know how animals feel. But with rats, we have a unique window into their emotional lives through their vocalizations. Rats make positive ultrasonic vocalizations when they play and when they're tickled. What is tickling? It mimics rat rough and tumble play, which rats will eagerly seek out. But how much time does this technique take? A recent publication by LaFollette et al, gives us that answer. Researchers tickled rats for a frequency of 1, 3, or 5 days and for a duration of 15, 30, or 60 seconds. They found that 3-days of tickling was the most efficient and effective. These rats produced more positive vocalizations before and during tickling, played more, and were less inactive in their home cage before tickling. However the duration of tickling didn't matter. This suggests that 3 short sessions of tickling can go a long way to make rats happier to interact with humans and to improve rat welfare. [NC3Rs] Many neuroscientific studies involve training nonhuman primates to perform cognitive tasks. But traditional training methods raise some key concerns. These include the need to separate animals from their home environment, causing them stress that affects both their welfare and their performance. Enter Mymou, a refined training system developed by James Butler and Steve Kennerley at University College London and described in a recent Behavior Research Methods paper. Mymou, named after the Greek word for "monkey" is a wireless touchscreen system that is installed in the home environment. It runs continuously, so monkeys can train whenever they want in familiar surroundings. Built in facial recognition allows different tasks to be assigned to different individuals while real-time data analysis means tasks can be adapted as training progresses. The set-up uses commercially available components and costs under £400, or around 500 USD. If that wasn't enough, Mymou is also fully open source, making it even easier to try out in any lab. Following the link in the description to find out more. See acast.com/privacy for privacy and opt-out information.

Kriben Govender (Honours Degree in Food Science & Technology) and James Shadrach (Honours Degree in Psychology) talk about the latest information around probiotics from Gut Brain Axis Conference 2018.   Brought to you by:   Nourishmeorganics- Gut Health Super Store https://www.nourishmeorganics.com.au/   Allele Microbiome- Microbiome Stool Testing https://www.allele.com.au/     Show Links:   Free Gut Health Guide: http://bit.ly/JoinNourishmeCommunity   Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features: https://www.cell.com/cell/fulltext/S0092-8674(18)31102-4     Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT: https://www.cell.com/cell/fulltext/S0092-8674(18)31108-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418311085%3Fshowall%3Dtrue     Clinical Guide to Probiotics: http://usprobioticguide.com/PBCIntroduction.html   23andme Genetic Testing: https://www.23andme.com/en-int/   Sterling Hill App: https://mthfrsupport.com/sterlings-app/   G6PDD Deficiency:    http://g6pddeficiency.org/wp/g6pd-deficiency-home/overview-of-g6pd-deficiency/#.W6t56BMzZBx   The Smiles Trial: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0791-y     Connect with me:  Facebook- https://www.facebook.com/kribengee/ Instagram- https://www.instagram.com/kribengovender/ Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/   Available on Itunes and Spotify   If you enjoyed this episode and would like to show your support:   1) Please subscribe on Itunes and leave a positive review     Instructions:   - Click this link  https://itunes.apple.com/au/podcast/gut-health-gurus-podcast/id1433882512?mt=2   - Click "View in Itunes" button on the left hand side - This will open Itunes app - Click "Subscribe" button - Click on "Ratings and Reviews" tab - Click on "Write a Review" button     2) Subscribe, like and leave a positive comment on Youtube   https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1   3) Share your favourite episode on Facebook, Instagram, and Stories 4) Let your friends and family know about this Podcast by email, text, messenger etc   5) Support us on Patreon for as little as $5 per month and get same day, early access to our latest podcasts (typically around 4 to 6 weeks earlier than the general public) https://www.patreon.com/nourishmeorganics   Thank you so much for your support. It means the world to us.

Scientist Niraj Trivedi and Comedian Mo Alexander join Mark in the studio to talk about 3 Dimensional microscopy, the fallability of lie detectors, and jokes in Sanskrit.Follow Mo Alexander on facebookhttps://www.facebook.com/comedianmoalexander/Check out Mo Alexander's websitehttps://www.moalexander.net/Check out the iDisco paper with the images Niraj was referencinghttps://www.cell.com/abstract/S0092-8674%2814%2901297-5Want to guest on the show? want us to cover a topic?  email us at: drhecklepod@gmail.comSPONSOR:Check out Launch Process Coffee located at 584 Tillman!

Stijn Mertens and Jan Steensels talk about what's happening inside one of the world's most advanced yeast labs.Links: The Belgian Beer Book: Belgian Beer Tested and Tasted The Yeasts of Tomorrow (2018 MBAA ETC) Yeast Family Tree

In this podcast, Marina Parry, ESMO Open Digital Editor, speaks to Nicholas McGranahan, Junior Group Leader of the Cancer Genome Evolution Group at University College London’s Cancer Institute about the role of bioinformatics in translating genomics research into the clinic and his most recent paper “Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution”, Cell, 2017 https://www.cell.com/cell/pdf/S0092-8674(17)31185-6.pdf. Read the full Abstract on the ESMO Open website.

In this edition, we’ll hear about how heritability traits can be inferred from electronic medical records, with Nick Tatonetti and Fernanda Polubriaginof, Cell (00:00); why fiber does wonders for your immune system, with Benjamin Marsland, Immunity (9:56); and what’s behind the high- energy demands of mining Bitcoin, with Alex de Vries, Joule (18:56).

In this episode, we’ll hear about why you might want to be skeptical of raw water, with Gail Teitzel, Editor of Trends in Microbiology (00:00); how brain chemistry might change in mice as a result of social isolation, with David Anderson, Cell (07:45); and what’s unusual about neurons in people with severe obesity, with Dhruv Sareen, Cell Stem Cell (17:10). Then, stay tuned for our monthly news roundup, including using MRI to predict risk tolerance; rethinking what we know about genetics, sugar, and weight gain; and how the sweet potato arrived in Polynesia (26:13).

Today’s episode features Dr. Valter Longo, director of the Longevity Institute at the University of Southern California. Valter is best known for his research on stem cells and aging as well as his fasting-mimicking diet. Often referred to as FMD, the diet is intended to avoid the downsides of fasting while reaping the health benefits of a calorie-restrictive diet. Over a 25-year career, Valter has published numerous papers about the ways specific diets can activate stem cells and promote regeneration and rejuvenation in multiple organs to reduce the risk for diabetes, cancer, Alzheimer’s and heart disease. He writes about this research and diet in a book that was released earlier this year, “The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease and Optimizer Weight.” The book details an easy-to-follow everyday diet that is combined with short periods of the fasting-mimicking diet. Valter says the diet has the potential to help people live healthier and longer lives. Valter is a native of Genoa, Italy and moved Chicago when he was 16. He received his bachelor’s of science degree at the University of North Texas in 1992 and his Ph.D. at UCLA in 1997. Links: Longevity Center website: http://longevityinstitute.usc.edu Longo’s USC faculty page: http://gero.usc.edu/faculty/longo/ “The Longevity Diet”: https://amzn.to/2s1fcky A periodic diet that mimics fasting promotes multi-system regeneration: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509734/ Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration: https://www.cell.com/cell/fulltext/S0092-8674(17)30130-7 Fasting-mimicking diet and markers/risk factors for aging: http://stm.sciencemag.org/content/9/377/eaai8700 Prolon FMD website: https://prolonfmd.com/fasting-mimicking-diet/?doing_wp_cron=1526216346.5062971115112304687500 Show notes: 2:24: Dawn opens the interview by mentioning that Valter was born and raised in Genoa, Italy, the hometown of Christopher Columbus. She asks if reports of him driving his neighbors mad playing Dire Straits, Jimmy Hendricks and Pink Floyd on his electric guitar as a youth are accurate. 2:43: Dawn asks Valter what his parents said when he tried to talk them into letting him go to London to be a rock star when he was 12 years old? 3:10: Valter left home when he was 16 to go visit an aunt in Chicago, but ended up staying in Chicago to go to school and play music. Dawn asks what that was like? 3:49: Dawn comments on how in addition to being exposed to some of the best blues music in the world, Valter also was exposed to some of the unhealthiest food in the world. Valter then talks about what he refers to as “the heart-attack diet.” 4:48: Dawn asks what lead Valter to attend the University of North Texas College of Music. 5:30: Valter joined the Army Reserve to help pay for college and ended up assigned to a battalion of Army tankers. Ken asks Valter what that was like. 6:15: Dawn asks if it’s true that the idea of directing a marching band lead Valter to switch majors as a sophomore. 7:07: Dawn comments on how not many jazz performance majors, who have never taken a biology course, decide to switch their major to biochemistry. She asks Valter what the people in the biochemistry department had to say about that. 8:04: Dawn mentions that when Valter was five years old, he saw his ailing grandfather pass away. She asks him to talk about that experience and the role it played in his decision to study aging. 9:14: Dawn mentions that after switching over to biochemistry and graduating from college in 1992, Valter headed to UCLA, which at the time was one of the world’s leading centers of longevity research. She asks Valter how that opportunity came about. 10:22: Ken brings up Valter’s work at UCLA in the lab of the pathologist, Roy Walford. Valter studied the effects of caloric restriction in the lab and ...

In this episode, we’ll hear about when children start to think about their reputations with Ike Silver, Trends in Cognitive Sciences (00:00); an indigenous people in Indonesia whose unusually large spleens enhance their free-diving ability with Melissa Ilardo, Cell (08:56); how the Pan-Cancer Atlas was put together, with Bob Kruger, Deputy Editor of Cell (17:55); and what’s unique about iScience, Cell Press’s newest research journal, with its Lead Editor Stefano Tonzani and Publisher Simanta Buck (24:10). Then, stay tuned for our monthly news roundup, including graphene hair dye, adaptive behaviors in the mouse brain, and improving indoor air quality with plants (32:20).

In this edition, we'll hear about new methods to monitor cannabis use, with Marilyn Heustis, Trends in Molecular Medicine (00:00); old tales of rabbit’s domestication, with Greger Larson, Trends in Ecology & Evolution (12:19); "walking fish" and the neural origins of land locomotion, with Jeremy Dasen, Cell (20:14); and how to balance safety and civil rights in access to personal genomic data, with Barbara Evans, AJHG (27:05). And this month’s news roundup: deep learning retinal diseases, wood carbon sponges, and batteries that withstand the coldest temperatures (36:15).

In this edition, we’ll hear about a new technique to inject information into the brain of monkeys, with Kevin Mazurek and Marc Schieber, Neuron (00:00); how to convert yogurt waste into biofuels, with Lars Angenent, Joule (9:31); why should we eat a high-fiber diet, with Fredrik Bäckhed, Cell Host & Microbe (16:45); and how CRISPR holds promise for epigenetic therapies, with Hsin-Kai Liao, Cell (22:09).

Blame Kevin for the delay on this one - it's hard to edit podcasts in Hong Kong.Today (well, three weeks ago), Matt and Kevin talked about epitope spreading in Lupus, and a ton of crazy mouse models that allowed researchers to dissect the way a single auto-reactive B-cell clone can spread the disease party to its neighbors. Also in this episode - Kevin complains about politicians' views on global warming (I can't link the map because of the government shutdown), and Matt totally doesn't have any conflicts of interest on this paper...Donate to us on Patreon! We've got some new goal tiers to reflect our desire for you to buy us drinks. Like us on Facebook! Send us your questions!Links- The Paper - Clonal evolution of autoreactive germinal centers (it's behind a paywall, and we definitely won't send you the PDF if you e-mail us at comments@emmunity.org... definitely not)- Blah, Blah, Blah IPA from 21st Amendment- What Matt was drinking. Not a mistake.

In this edition, we hear about how bacteria may influence the reproduction of other species, with John Clardy and Nicole King from Cell (00:00); how new technology is making windows smart about light and temperature, with Michael McGehee from Joule (10:35); and a behind-the-scenes peek at first year of the new journal Chem with Editor Rob Eagling (18:15).

Chromatin Immunoprecipitation (ChIP) was first developed in Drosophila, where interactions of RNA Pol II with genes were investigated (Mol. Cell. Biol. August 1985 vol. 5 no. 8 2009-2018). Then, in a 1993 publication, (Genes & Dev. 1993 7:592-604), the group of James Broach described the association of histone acetylation state with transcriptional gene silencing in yeast. The technique was first used successfully in mammalian cells by Richard Treisman's group, published in 1998 (Cell (1998) 92:475-87).Chromatin Immunoprecipitation is used to link specific states of chromatin to individual loci in a cell, to understand how genes are regulated, and to decipher the Histone Code. In this Episode, we discuss the multiple challenges of ChIP experiments and the difficulties that can arise during different steps of the process. References for this episode Epigenetics News: Chung-Chau Hon, Jordan A. Ramilowski, … Alistair R. R. Forrest. An atlas of human long non-coding RNAs with accurate 5′ ends. Nature. March 2017. doi:10.1038/nature21374 Jennifer L. Guerriero, Alaba Sotayo, … Anthony Letai. Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages. Nature. March 2017. doi:10.1038/nature21409 Nitika Taneja, Martin Zofall, … Shiv I. S. Grewal. SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication. Molecular Cell. April 2017. DOI:10.1016/j.molcel.2017.02.006 Multiple Challenges in ChIP D. S. Gilmour, J. T. Lis. In vivo interactions of RNA polymerase II with genes of Drosophila melanogaster. Molecular and Cellular Biology. August 1985. doi:10.1128/MCB.5.8.2009 M. Braunstein, A. B. Rose, … J. R. Broach. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes & Development. 1993. doi:10.1101/gad.7.4.592 Arthur S. Alberts, Olivier Geneste, Richard Treisman. Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation. Cell. February 1986. doi:10.1016/S0092-8674(00)80941-1 Active Motif Contact Details Follow us on Twitter Join us on LinkedIn Like us on Facebook Email us @Active Motif Europe or Active Motif North America.

In this edition, we learn about how sleep changes with age, with Matthew Walker Neuron (00:00), how a genetic mutation in some people is linked to “night owl” behavior with Mike Young Cell (11:40), and what obese fruit flies can teach us about the relationship between weight and the weather, with Aurelio Teleman Developmental Cell (18:50).

On this week's holiday episode our News & Views segment starts at Krispy Kreme to see if we can extract any good take-aways from the recent class-action lawsuit filed against the chain. Then, it's on to a recent study about what happens when you don't feed your gut bacteria...what do they eat instead? The segment is rounded out with coverage of recent research on whole milk for kids and a new—somewhat strange–non-pharmaceutical weight-loss pill. The Moment of Paleo segment offers thoughts on restriction and upcoming holiday feasts. And After the Bell features a talk about life's invisible feast. Enjoy the show! Links for this episode:Latest in Paleo on Facebook — Leave a Comment About this Episode or Post a News LinkWhy & How to Support Latest in PaleoRecommended Food & ProductsRecommended Books & AudiobooksKrispy Kreme Lawsuit Claims Company Misled Over Doughnut FruitA Fruitless Suit?: Krispy Kreme Sued Over Fake Berry-Flavored Donuts - Law Street (TM)Kreme-filled lies — Doughnut company faces a Krispy $5M lawsuit - NY Daily NewsA Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility: CellHigh-fiber diet keeps gut microbes from eating the colon’s lining, protects against infection, animal study shows | University of Michigan Health SystemEating fiber keeps gut microbes from eating you - Medical News TodayEat Fiber: Whole Grains Prevent Gut Microbes From Eating Intestine Lining, Increasing Infection Risknew The Hungry Microbiome: why resistant starch is good for you - YouTubeWhich Foods to Eat: The Hungry MicrobiomeRelation between milk-fat percentage, vitamin D, and BMI z score in early childhoodDo we have it backward on giving kids low fat milk instead of whole? - Health - CBC NewsKids who drink whole milk slimmer than those who don'tUses for skim milk before it was marketed as a nonfat diet product: Hog slop and wool.A 6-Month Swallowable Balloon System Results In Sustainable Weight Loss At 1 Year: Results from A Prospective, Randomized Sham-Controlled Trial - Surgery for Obesity and Related DiseasesBalloon-in-a-Pill Helped Obese Patients Lose Weight: MedlinePlus Health NewsThis Weight Loss Pill Inflates a Balloon In Your Stomach | TIMEWeight-loss balloon helps shed twice the weight, research says - CNN.comWatch "Possibilities—life's invisible feast: Sarah Susanka at TEDxSanDiego" Video at TEDxTalksVisit PuraKai to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

We have some hair-raising pieces this month, starting with a timely look at how voters make decisions about which candidate to support, with Libby Jenke and Scott Huettel, Trends in Cognitive Sciences (00:00); how a newly discovered gut protist protects mice from Salmonella, with Aleksey Chudnovskiy Cell (8:55); and a true story from one Cell Press employee who survived a lightning strike while camping with her kids CrossTalk (15:00). Plus, insight into how snakes lost their legs and much more!

Should you feed a cold and starve a fever? We’ll see what the science says, with Ruslan Medzhitov, Cell (00:00). Also, just in time for Oktoberfest: a look at the history of beer yeast, with Kevin Verstrepen, Cell (6:15). Finally, a STAR is born as Cell Press unveils a new approach to the methods section. Find out what’s changing, and how it’s designed to help you, with Ann Goldstein (13:10).

Busy Episode this time! Crammed with like - additional feedback to last episode's Staling results. Seems like some of you have been using scary old grain! In the pub we stop and talk a while about Denny's Hop School experiences (more on those later), the law in California and the crushing "loss" of Bosteels Brewery to ABI. (Maybe they should be Boo-steels now?) and one brewery's response to the recent PR campaign to try and make everyone feel better about the buyouts. We swing by the brewery to talk about Drew's recent Saison yeast tasting - which you can find online. In the library we visit a couple of papers on yeast genetics. In the lab, we're happy to announce our next great experiment - brought to you by our sponsors, the American Homebrewer's Association and NikoBrew.com. We're going to get a whole squad of homebrewers making up some hoppy beers and having them analyzed and tasted! See the recipe and experiment writeup for details. We're super stoked for this! Then Denny goes and talks to the folks out of Whirlpool's W Labs about their soon to launch all in one fermenter, fridge, kegerator - the Vessi. Then he heads off to the posh environs of Bainbridge Island WA to talk with Russell Everett of Bainbridge Brewing. Listen and find out what stout and noodles have to do with each other. Then in Something Other Than Beer - we lament 2016's continuing losses - this time with Gene Wilder. Then Drew shares Sia's new video for "The Greatest" which is a bit of a gut punch. Lastly, to leave on a happy note - Drew also mentions Comixology for all your comic enjoyment. Finally Denny drops a tip about how best to dry your hops. The key - a little bit of heat, but not too much if you want to preserve all the good oils! Episode Links: Staling Experiment - https://www.experimentalbrew.com/experiments/impact-crushed-malt-age-bee... YCH Hop School - https://ychhops.com/connect/events/home-brewing/hop-and-brew-school AB-2172 - http://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=201... Bosteels buyout - http://www.brewbound.com/news/b-inbev-acquire-belgiums-brouwerij-bosteels Modern Times Response to Selling Out - http://moderntimesbeer.com/blog/what-selling-out?cc Drew's Saison Yeast Tasting - https://www.experimentalbrew.com/blogs/drew/saison-files-tasting-saison-... Lar Blogs - Yeast Genetcs - http://www.garshol.priv.no/blog/349.html Cell - Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts - http://www.cell.com/cell/fulltext/S0092-8674(16)31071-6 The Great Hop Experiment - https://www.experimentalbrew.com/experiments/great-ibu-test Vessi - https://www.indiegogo.com/projects/vessi-beer-fermentor-and-dispenser--4 Bainbridge Island Brewing - http://www.bainbridgebeer.com/ Something Other Than Beer - Gene Wilder - https://www.youtube.com/watch?v=0tE1T2ys7qo Something Other Than Beer - Sia - The Greatest - https://www.youtube.com/watch?v=GKSRyLdjsPA Something Other Than Beer - Comixology - https://www.comixology.com/ Patreon Remember even a buck is good for charity: http://www.patreon.com/experimentalbrewing Experimental Brew Store - https://www.experimentalbrew.com/store Episode Contents: 00:00:00 Our Sponsors 00:04:13 Support Us 00:05:19 Listener Feedback 00:13:44 The Pub - Hop School, California Law, Sellouts 00:28:00 The Library - Yeast Genetics 00:42:00 The Lab - The Great IBU Experiment Announcement 00:52:48 The Lounge - W Labs - Vessi 01:12:24 The Lounge - Russel Everett - Bainbridge Island Brewing 01:54:01 Something Other Than Beer - Gene Wilder, Sia, Comixology 02:00:43 Quick Tip - Hop Drying This episode is brought to you: American Homebrewers Association BrewCraft USA Craftmeister NikoBrew PicoBrew Wyeast Labs Interested in helping Denny and Drew with the IGOR program (aka help us run experiments!) - contact them at igor@experimentalbrew.com. We want more Citizen Science! In the meanwhile, subscribe via your favorite podcasting service (iTunes, etc). Like our podcast, review it - talk it up! If you have comments, feedbacks, harassments, etc, feel free to drop us a line at podcast@experimentalbrew.com. Follow us on Facebook (ExperimentalHomebrewing) or Twitter (@ExpBrewing). If you have questions you'd like answered in our Q&A segment, send an email to questions@experimentalbrew.com! Don't forget you can support the podcast on Patreon by going to http://patreon.com/experimentalbrewing This episode can be downloaded directly at http://www.podtrac.com/pts/redirect.mp3/www.experimentalbrew.com/sites/d... Podcast RSS Url: http://www.experimentalbrew.com/podcast.rss

In this edition, we’ll discuss why the street drug ecstasy deserves research as a potential therapeutic, with Robert Malenka, Cell (00:00); how fiction might be good for you, with Keith Oatley, Trends in Cognitive Sciences (8:35); and why we get breast or colon cancer, but not heart cancer, with Frédéric Thomas, Trends in Cancer (18:30).

In this edition, we learn some surprises about the stability of the skin microbiome, with Julia Oh and Heidi Kong, Cell (00:00), and how antibiotics can cause long-lasting disruption in the normal functions of helpful gut microbes, with Eric Pamer and Simone Becattini, Trends in Molecular Medicine (11:30). Plus, we have a slew of science highlights from around Cell Press (19:30)!

In this edition, we learn how the Zika virus affects fetal development, with Guo-li Ming, Hongjun Song, and Hengli Tang, Cell Stem Cell (00:00), how fungi may be used to create batteries, with Geoffrey Gadd, Current Biology (5:45), how organs can be mimicked with chip technology, with Donald Ingber, Cell (11:40), and a personal story about travel and the Zika threat, with Simanta Buck (18:05). Plus much more!

Last November, Cell published a popular study explaining how the glycemic response to foods can differ greatly by individual. This landmark paper on personalized nutrition has since yielded follow-up research and a perspective on how our gut microbes play a role in our individual responses to diet. Catarina Sacristan discusses the findings with Eran Elinav and Eran Segal of the Weizmann Institute of Science.Related Papers: Cell Host & Microbe, Zmora, Zeevi, and Korem et al.: Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease; Cell, Levy and Thaiss et al.: Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling; Cell, Zeevi and Korem et al.: Personalized Nutrition by Prediction of Glycemic Responses

Today's show opens with documentary and book recommendations. Then, in the News & Views segment: Study suggests healthy diets must be individualized; how the Western diet is derailing evolution. In the Shinrin-Yoku Update: How access to nature affects communities; disturbing losses in the Amazon. We have a Moment of Paleo segment on risk and thankfulness. To close things up, the After the Bell segment is about how to staying calm and make better decisions when we know a stressful situation is coming up. Links for this episode:Full List of Recommended Books & AudiobooksLatest in Paleo on Facebook - News hunters and gatherers post your links here.This episode's homepage with sectioned show notes & moreSeeds of Permaculture - Tropical Permaculture - YouTubePersonalized Nutrition by Prediction of Glycemic Responses: CellPersonalized Nutrition: Healthy foods are unique to individualsWhat is healthy eating? | Life and style | The GuardianThe Algorithm That Creates Diets That Work for You - The AtlanticThe Future of Dieting Is Personalized Algorithms -- Science of UsA good diet for you may be bad for me | Science NewsUniversal diets don’t work because ‘healthy’ foods differ by individual, study finds - ScienceAlertThere Really Is No 'One Size Fits All' Diet Plan, According To StudyIf Your Diet Isn't Working, New Research Has A Theory Why (VIDEO) | Sci/Health > HealthPersonalized Nutrition by Prediction of Glycemic Responses | The poor, misunderstood calorieScience AMA Series: We are David Zeevi and Tal Korem, graduate students at the Weizmann Institute of Science, and authors of a recent study which showed that people respond differently to the same food, Ask Us Anything! : scienceHow Burgers and Fries Are Killing Your Microbial BalanceQ&A With a Gut Microbiome Scientist - US NewsThis New Personal Poop Banking Service Lets You Save Your Microbiome For A Rainy DaySeeing Community for the Trees: The Links among Contact with Natural Environments, Community Cohesion, and CrimeMore Than Half Of Amazonian Tree Species Face Extinction (VIDEO) | World > South AmericaSponsored in part by PuraKai. Visit purakai.com to shop for eco-friendly clothing and stand-up paddle boards. Be sure to use coupon code "latest in paleo" for 15% off all clothing purchases.

Jennifer Quint (Thorax’s Journal Club editor) talks to Frank McKeon (Genome Institute of Singapore, Harvard Medical School) about his work into the extent of lung regeneration following catastrophic damage and the potential role of adult stem cells. Dr McKeon’s latest paper, published in Cell, examines airway regeneration in mice after H1N1 influenza infection.See also:http://www.cell.com/abstract/S0092-8674%2811%2901173-1

We're wrapping up season 3 with a recap of all of our incredible guests we had on our podcast, as well highlights from the top biohacking tips we discussed this year. If you missed any episodes, this is a great opportunity to figure out which episode to go back to and check out first! *SHOW NOTES:* 1:20 Welcome to the show! 3:58 The most topical issue of the year Ep 51 - COVID Susceptibility & The Quarantine 15 ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000484603472 ) (Renee’s experience) Ep 60 - Same Same, but Different ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000491185777 ) (Ryan’s experience) 5:58 OURA Ring Study 9:11 Tracking & Testing Blood Sugar Ep 58 - Optimizing Blood Sugar ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000489645703 ) with Dr. Casey Means Ep 61 - Q&A with Dr. Casey Means ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000491964124 ) 12:11 STUDY: Personalized Nutrition based on Glycemic responses ( https://www.cell.com/fulltext/S0092-8674(15)01481-6 ) 14:01 Carnivore vs Vegan Diet research 15:35 Advice on going Plant-based 16:07 Alcohol as a Neurotoxin & Blood Sugar Disruptor 16:35 The lifestyle & health “cost” of drinking Ep 57: Alcohol-Free Lifestyle ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000488990721 ) with James Swanwick 19:53 Blue light-blocking “Swannies” 20:20 Dry Farm Wines vs Commercial wines Ep 62: An Insider’s Look at the Wine Industry ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000492797522 ) with Todd White 24:59 Testing for Genetic Variants Ep 68: Self-Decoding Your Genetics ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000497753207 ) with Joe Cohen 27:15 Hacking Ketones & Glucose Ep 70: Find Your Mojo ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000499904292 ) with Dorian Greenow 27:51 The problem with commercial agriculture 29:45 “Don’t go chasing ketones” 31:40 Ixcela Wellness Test for Gut Health Ep 74: Testing the Microbiome with Erika Ebbel Angle 32:41 Why you need to work with a health practitioner 33:05 Testing + Optimizing with Biofeedback 33:23 EEG Brain Mapping 24:39 Disassociating the brain from addiction Ep 56: Neurofeedback & Brain Health ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000488364818 ) with Dr. Andrew Hill 36:05 Biohacking Your Bed & Sleep Ep 71: EightSleep Mattress ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000500792751 ) with Matteo Franceschetti 38:12 Optimizing thermoregulation with tech & push notifications 39:30 Heart Rate Variability Ep 69: What Your Heart is Telling You ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000498822404 ) with The BBs 40:15 The toxic air we breathe Ep 52: Air Pollution & Immune Dangers ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000485502800 ) with Eileen Durfee 41:43 How toxins affect us on the cellular level 43:45 The dangers of EMFs 45:28 Defender Shield products for self-protection Ep 53: EMFs & Radiation ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000486252510 ) with Daniel DeBaun 47:06 The power of RED LIGHT Ep 66: Light Therapy Healing ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000496091246 ) with Scott Kennedy 47:49 “Light therapy only does one thing, but it does it really well” 50:31 Interviewing fellow Health Practitioners Ep 64: Beliefs & Biological Healing ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000494439618 ) with Christine Dionese Ep 54: Past, Present & Future of Biological Medicine ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000486955809 ) with Dr. Jeoffrey Drobot Ep 72: Women’s Biohacking Roundtable ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000501589387 ) with Angela Foster 54:27 Teaching your kids about health & biohacking 54:53 Deuterium exposure & chronic disease Ep 73: The Water Secret You Need to Know ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000502330453 ) with Dr. Que Collins 55:47 Biohacking cancer for humans & animals 57:15 Optimizing sleep with nootropics & sleep hygiene 58:00 Honoring different sleep chronotypes 59:49 Signal vs Noise in the body Ep 59: The Dirty Truth on Sleep Deprivation ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000490342943 ) with Dr. Greg Kelly 1:00:27 Clean supplements & foods 1:00:40 Crohn’s Disease & Post-Partum Depression 1:01:19 The synergistic of effects of plant superfoods Ep 65: Clean, Toxin-Free Smoothies ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000495257374 ) with Ingrid De La O 1:03:53 The powerful female entrepreneur Ep 67: Gut Health & Probiotics ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000496914587 ) with Kiley Anderson 1:06:14 A personal episode, just the two of us Ep 63: Interviewing the Babes ( https://podcasts.apple.com/us/podcast/biohacker-babes-podcast/id1470189843?i=1000493631858 ) 1:06:42 Key takeaways from this season 1:08:28 Requesting episode topics 1:09:10 Biohacker Babes’ January Challenge 1:09:30 Thank you & Happy Holidays 1:10:25 Thanks for tuning in! *RESOURCES:* Book: The Immunity Fix ( https://www.amazon.com/gp/product/B08M1QXXF6/ref=as_li_tl?camp=1789&creative=9325&creativeASIN=B08M1QXXF6&ie=UTF8&linkCode=as2&linkId=83fd541344b5a50095f8188cc5ab133d&tag=laurensamba04-20 ) Levels Health ( http://levels.link/biohackerbabes ) - Use this link to skip the waitlist Swanwick ( https://www.swanwicksleep.com/?affid=693000&oid=1 ) James Swannick's Alcohol-Free program ( https://30daynoalcoholchallenge.com/ ) Dry Farm Wines ( https://www.dryfarmwines.com/pages/pennybottle?rfsn=1823540.5ccb47 ) - first bottle for a penny! Self Decode Genetic Testing ( https://selfdecode.com/?a_aid=biohackerbabes ) - Code: BIOHACKERBABES for 10% off SelfHacked ( https://selfhacked.com ) - Blog Keto-Mojo ( https://shop.keto-mojo.com/discount/nji98uhbvgy76tfc?rfsn=4573797.f77fee&utm_campaign=4573797.f77fee&utm_medium=affiliate&utm_source=refersion ) Ixcela Wellness ( https://go.ixcela.com/enroll ) - Use Pro Code: RENEEBELZ Peak Brain ( http://peakbraininstitute.com/brain-training/neurofeedback/ ) EightSleep ( https://www.eightsleep.com ) Creatrix Solutions ( https://www.creatrixaffiliates.com/188.html ) Defender Shield ( https://www.defendershield.com/?ref=reneebelz ) - BIOHACKERBABES for 20% off Christine Dionese ( https://christinedioneseconsulting.com ) BioMed Centre ( https://thebiomedcenter.com ) Neurohacker ( https://neurohacker.com/?rfsn=4449318.a67cd4 ) - Code: BIOHACKERBABES for 15% off Tusol Wellness ( https://tusolwellness.com/biohackerbabe?rfsn=4600201.12fe591 ) - Code: BIOHACKERBABE for 15% off Jetson Probiotics ( https://wearejetson.com ) THEBIOHACKERBABES.COM ( www.thebiohackerbabes.com ) Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donations

*In today's episode, we interview Dr. Casey Means, co-founder of the Metabolic Health company, Unlock Levels. Her mission is to maximize human potential and reverse the epidemic of preventable chronic disease by empowering individuals with tech-enabled tools that can inform smart, personalized, and sustainable dietary and lifestyle choices. We discuss how to holistically look at glucose levels and insulin to optimize health potential, maximize fat loss, and strengthen immune health.* 1:21 Welcome to the show! 2:15 Dr. Casey Means’ Bio 3:12 Welcome Dr. Casey! 4:23 CGMs & metabolic health 5:17 The varying spectrum of Metabolic Dysfunction 6:59 How Glucose COULD vs SHOULD respond to food 8:54 Why so many people don’t know they have Pre-Diabetes & how to test 10:24 Why Pre-Diabetes is under-diagnosed 11:30 The ranges we should be aiming for 11:54 STUDY: Optimal glucose ranges 14:38 “Normal” vs “Optimal” lab ranges 14:58 Researcher Todd Rose: “End of Average” book 16:18 Behaviors leading to chronic disease 16:54 Benefits of wearables for personalized healthcare 19:17 There is no one-size-fits-all approach 19:43 STUDY: Personalized nutrition & glycemic variability 21:20 Oatmeal marketed as “heart healthy” 22:38 Glycemic Index & Load myth 24:54 Assessing the Gut Microbiome 26:09 DayTwo stool analysis 27:59 Probiotic to lower HbA1c 30:14 Dietary changes for the gut microbiome + probiotics 32:37 The ideal 24-glucose & insulin picture 35:27 Glucose & Inflammation 35:49 Glycation problems 36:44 Oxidative-stress & Free Radicals 387:54 “Hills vs Mountains” 38:22 What’s considered ‘normal’ (see Levels blog) 40:55 “Reactive Hypoglycemia” 42:10 Why we can’t burn fat! 43:21 The MYTH about eating breakfast 44:20 STUDY: Time-Restricted Feeding 46:15 Lauren’s experience with snacking 47:33 Using Biofeedback & tech 48:32 Tracking glucose levels during sleep 49:57 CGM recommendations overnight 51:19 STUDY: Fasting glucose & disease risk 52:31 Pressure-induced sensor error 55:20 The impact of exercise 59:15 STUDY: Benefits of walking on glucose 1:01:42 The impact of hormetic stressors 1:02:30 Working out in a fasted state 1:06:15 Carb cycling & Fat adaptation 1:08:10 The future of CGMs 1:09:55 Risk factors for common diseases 1:13:58 Risks for COVID mortality 1:15:44 Her one piece of advice 1:17:41 Where you can find Dr. Casey 1:19:02 Thanks for tuning in! *RESOURCES:* Levels Health Website ( https://www.levelshealth.com/ ) Levels Health Blog ( https://www.levelshealth.com/blo ) *Unlock Levels:* IG: https://www.instagram.com/unlocklevels/ Twitter: https://twitter.com/unlocklevels *Dr Caseys Kitchen:* IG: https://www.instagram.com/drcaseyskitchen/ Twitter: https://twitter.com/DrCaseysKitchen Pendulum Probiotics ( https://pendulumlife.com/products/pendulum-glucose-control-2 ) KetoMojo ( https://shop.keto-mojo.com/discount/nji98uhbvgy76tfc?rfsn=4573797.f77fee&utm_campaign=4573797.f77fee&utm_medium=affiliate&utm_source=refersion ) *Fasting Apps: Zero & Life:* LIFE App ( https://lifeapps.io/apps/life-fasting-tracker/ ) Zero App ( https://www.zerofasting.com ) *STUDIES & ARTICLES:* HVMN Carb Cycling article for Athletes ( https://hvmn.com/blogs/blog/training-carb-cycling-guide-for-athletes ) Personalized Nutrition by Prediction of Glycemic Responses ( https://www.cell.com/action/showPdf?pii=S0092-8674%2815%2901481-6 ) Contextualising Maximal Fat Oxidation During Exercise ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974542/ ) Breaking Prolonged Sitting Reduces Postprandial Glycemia in Healthy, Normal-weight Adults ( https://academic.oup.com/ajcn/article/98/2/358/4577190 ) Creating an Optimal Diet by Tracking Glucose with a Continuous Glucose Monitor (CGM) ( https://www.levelshealth.com/blog/optimal-diet ) Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donations