Group of physiologically active lipid compounds
POPULARITY
3 episodes with prostaglandin
2 episodes with prostaglandin
3 episodes with prostaglandin
2 episodes with prostaglandin
2 episodes with prostaglandin
This week we replay episode #203 with Professor Michael Freed of Harvard University, who died this past week. In this episode from 2022 we review his seminal paper on prostaglandin for the treatment of infants with critical congenital heart disease from 1981 and then speak with Dr. Freed about his life, career, the development of PGE1 and more in this wide-ranging interview with this pediatric cardiology pioneer. Dr. Freed shares important career advice as he would to cardiology fellows during his long and illustrious career, advising and shaping the careers of pediatric cardiologists for 5 decades. doi: 10.1161/01.cir.64.5.899.
BUFFALO, NY- December 10, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 18, 2024, entitled, “Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes.” Researchers Elise Srour, Nathalie Martin, Claire Drullion, Clémentine De Schutter, Joëlle Giroud, Adrien Pioger, Julie Deslé, Laure Saas, Joe Nassour, Julien Théry, Gauthier Decanter, Nicolas Penel, Chantal Vercamer, Clara Salazar-Cardozo, Corinne Abbadie, and Olivier Pluquet from CNRS, University of Lille, the Oscar Lambret Center, and the University of Colorado School of Medicine have revealed how a molecule called Prostaglandin E2 (PGE2) influences skin aging and cancer risk. Their study shows that PGE2 not only drives skin cells to age but also enables some of these aging cells to bypass natural limits and develop into pre-cancerous cells. This process provides insights into why older skin is more susceptible to cancer. The study focused on keratinocytes, the primary cells in the outer layer of the skin. As these cells age, they enter a state called senescence, where they stop dividing to prevent damaged cells from turning cancerous. While this process typically serves as a protective mechanism, the researchers found that, in certain cases, some senescent cells can escape this state, re-enter the cell cycle, and acquire characteristics of early cancer. By examining keratinocytes from donors of different ethnicities and ages, the researchers identified the PTGS2/PGE2/EP4 pathway as a key driver of this escape process. The researchers show that blocking PGE2 or its associated pathway reduced the chances of aged cells becoming precancerous. This suggests that drugs targeting this pathway, including some anti-inflammatory medications already in use, might be repurposed to slow skin aging and prevent early-stage skin cancers. Additionally, the study also found that PGE2 levels increase in the skin as it ages, further supporting its role in skin health and disease. "These results indicate that the PTGS2/PGE2/EP4 pathway is required to induce and maintain the senescent phenotype of NHEKs, and that PGE2 level is a potential determinant of the initial steps of the age-related oncogenic process." The team also highlighted the broader implications of their work. The PTGS2/PGE2/EP4 pathway is not only linked to skin health but also to age-related inflammation, a condition that contributes to several diseases. By addressing this pathway, researchers hope to address not only skin aging but other health challenges linked to aging and chronic inflammation. In conclusion, this study reveals important molecular drivers of skin aging and early cancer, leading the way for new approaches that can promote healthier skin. DOI - https://doi.org/10.18632/aging.206149 Corresponding author - Olivier Pluquet - olivier.pluquet@ibl.cnrs.fr Video short - https://www.youtube.com/watch?v=4aNf3X2RJSw About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Send us a Text Message.What happens when you're expecting a baby with a congenital heart defect during a global pandemic? Join me, Anna Jaworski, as I sit down with Amelia Woods, a courageous heart mom who faced this exact challenge. Amelia shares the emotional rollercoaster of managing her son Henderson's dextrotransposition of the great arteries (d-TGA) diagnosis at 25 weeks' gestation. We explore the intricate preparations for Henderson's birth and his crucial surgeries, including the atrial balloon septostomy and the arterial switch procedure, all while navigating the complexities imposed by Covid-19.Amelia and her husband, Richard, had to master the art of setting boundaries to protect their medically fragile newborn amidst an unprecedented health crisis. Amelia opens up about the isolation they felt and the essential bonding time that these boundaries provided. She candidly discusses the importance of connecting with other heart moms for support, while also maintaining a degree of privacy for Henderson's future. Together, they reveal their strategies for navigating the postpartum period and the significance of familial support during such trying times.In this heartfelt episode, we also spotlight Amelia's advocacy within the congenital heart defect (CHD) community. By writing a book, "The Boy Born Brave," Amelia is a beacon of resilience and activism. We delve into actionable steps you can take to raise awareness and support the CHD community, including nonprofit fundraisers and heart walks. Tune in to learn how combining unique talents can drive nonprofit success and how you, too, can make a difference in the lives of children with CHD.Information Mentioned in the Episode:Amelia's website: https://heartlikeamother.com Amelia's shop: @heartlikeamother.shopAmelia on Instagram: @heartlikeamotherBecome a subscriber: https://www.buzzsprout.com/62761/supportWe appreciate it when people support Hearts Unite the Globe podcasts. Thank you to our newest supporters -- Annie Ulchak (Patreon) and Judy Miller (Buzzsprout)!Support the Show.Anna's Buzzsprout Affiliate LinkBaby Blue Sound CollectiveSocial Media Pages:Apple PodcastsFacebookInstagramMeWeTwitterYouTubeWebsite
Jaký je vztah mezi Pornem a Štěstím? Ve dnešním dílu se bavíme o systému našich chtíčů, o tom, jak porno ovlivňuje chování v intimních chvílích nebo o tom, jak vrstvení potěšení mění naše primární zdroje potěšení. Může být porno prospěšné? Jaký efekt má porovnávání porna a Seggsu? A kdy může škodit? Proč jsou muži po aktu ospalí? Jak Porno pomáhá kompenzovat nepříjemné emoce a jak s tím můžeme pracovat? Jak pracovat s kompulzivním chováním? To vše a mnohem víc ve dnešním peprném dílu! Odebírej VIP krátký formát RED PILL na našem Spotify jen za 65,- / měsíc ttps://podcasters.spotify.com/pod/show/brainweare/subscribe Parťákem dnešního dílu je GymBeam https://gymbeam.cz/ https://gymbeam.cz/ zadej kód BWA5 pro 5% slevu a koukni na naše oblíbené produkty od proteinů, až po nootropika Minutáž: 01:01 Odkud plyne potěšení 02:15 Ztišování mysli & Jak funguje dopamin 03:17 Sociální sítě aneb Scrolluješ u ranního sra...? 04:36 Primární zdroje štěstí 05:57 Sociální zdroje & Seggs 08:13 Porovnáváme se při Seggsu? 12:21 Zdroje potěšení & Telefon jako externí stimulace 21:00 Škálování uspokojení Dopaminem 23:52 Co znamená Hédonická adaptace & Příklad Mekáče na Sahaře 29:31 Dopaminová trajektorie & Co když klesá dopamin? 35:40 Citát: Potěšení VS Prožívání 37:10 Experiment: Zkus si pustit P*rno... 39:42 Jsou představy lepší než P*rno? 41:00 Co je to Prostaglandin? aneb Proč nechceš 2. kolo 44:05 Ženský orgasmus & Porno u žen 45:15 Kompulzivní chování: Co to je? Kdo to má? PRAXE a TIPY 49:25 Praktické rady pro kompulzivní chování 54:15 Jedno řešení pro nával frustrace 57:35 Citát: Slast VS Důsledek slasti 57:58 Antihédonistické aktivity & Co to je? 59:37 No-go signály & Inhibiční okruhy 01:02:57 Silný nástroj aneb Já VS Ty perspektiva 01:06:11 P*rno VS Meditace aneb Extrémy stimulace 01:07:49 Citát: Nuda VS Mír 01:08:42 Scitilivování potěšení pomocí Vděčnosti 01:11:50 Shrnutí & Závěr
Today, I am diving into the antimicrobial synergy between a bioactive compound called CAPE (found in propolis) and the LL-37 antimicrobial peptide. We explore how and why these may act synergistically and further dive into my personal antimicrobial stacks. You don't want to miss this one! Topics: 1. Introduction to Propolis - Definition of Propolis - How Bees Produce Propolis - Functions of Propolis in the Hive - Factors Influencing Propolis Composition 2. Key Bioactives in Propolis - Overview of Bioactive Compounds - Notable Compound: Caffeic Acid Phenethyl Ester (CAPE) 3. CAPE's Biological Activities - Modulating Inflammation - Inhibiting Arachidonic Acid (AA) Release From Cell Membrane - Impact on Prostaglandin and Leukotriene Production - Inhibition of LOX and COX Enzymes 4. CAPE's Anti-Biofilm and Antimicrobial Properties - Effectiveness Against Candida albicans - Inhibition of Biofilm Formation - Stimulation of Endogenous Antimicrobial Peptides - Focus on β-defensin 3 - Synergy with LL-37 Peptide 5. LL-37 Peptide - Introduction to Cathelicidins - Role of LL-37 - Mechanism of Action - Immunomodulatory Effects 6. Considerations and Precautions - Potential Herxheimer Reaction - Dosage for LL-37 - Dosage Estimate for CAPE in Propolis 7. Conclusion and Safety - Importance of Consulting a Licensed Physician - Wrapping Up the Discussion Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Have you been told you may need to be induced? Want to understand why, and what some of the medical reasons for induction are and how it may be performed? Will you need some help to deliver your baby? Then this week's episode of The Expert Guide to Parenthood podcast is for you. Birth isn't always easy or predictable. Sometimes medical intervention is needed to ensure the safety of mother and/or baby. In this episode Obstetrician and Gynecologist Expert Dr Peter Jurcevic talks about why women may need to be induced, and the different methods, including: - Prostaglandin gel - Synthetic Oxytocin - Amnihook - Cook Induction Balloon Catheter Dr Peter Jurcevic discusses the percentages of women who may need help to deliver their baby and the different methods and instruments involved. Make sure you subscribe to The Expert Guide To Parenthood Podcast and share this episode with all of your pregnant friends. Never forget parents you've got this! Follow us Social: Instagram: @parentsyouvegotthis_au Threads @parentsyouvegotthis_au TikTok: @partentsyouvegotthis_au Facebook: @parentsyouvegotthis ____________________________________ Parents You've Got This offers antenatal and postnatal parenting education and Masterclasses from the planning phase to early preschool. Learn more: https://www.parentsyouvegotthis.com.au/ Credits: Producer Dean Thomas, Camera person Tim Hehir, Content Parents You've Got This
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.04.535590v1?rss=1 Authors: Liu, Y., Guo, J., Matoga, M., Korotkova, M., Jakobsson, P.-J., Aguzzi, A. Abstract: Oligodendrocyte-lineage cells of patients and animal models undergo prominent changes in various neurodegenerative disorders. This raises the question of how myelinating cells interact with neurodegenerative processes. Here, we investigated the role of oligodendrocyte precursor cells (NG2 glia) in prion infections. We found that NG2 glia were activated in prion-infected cerebellar organotypic cultured slices (COCS) and in brains of prion-inoculated mice. In both model systems, depletion of NG2 glia exacerbated prion-induced neurodegeneration and accelerated prion pathology, suggesting a protective effect for NG2 glia. Loss of NG2 glia unleashed a microglial reaction promoting the biosynthesis of prostaglandin E2 (PGE2), which augmented prion toxicity in HovS cells and COCS through binding to the EP1 and EP4 receptors. Pharmacological or genetic inhibition of PGE2 biosynthesis attenuated prion-induced neurodegeneration in COCS and mice, antagonized the enhanced neurodegeneration in NG2 glia-depleted COCS and brains after prion infection, and dampened the acceleration of prion disease in NG2 glia-depleted mice. These data unveil a non-cell-autonomous interaction involving NG2 glia and microglia in prion disease and suggest that PGE2 signaling may represent an actionable target against prion diseases. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.01.526734v1?rss=1 Authors: Watabe, T., Yamahira, S., Takakura, K., Thumkeo, D., Narumiya, S., Matsuda, M., Terai, K. Abstract: Prostaglandin E2 (PGE2) is a key player in a plethora of physiological and pathological events. Nevertheless, little is known about the dynamics of PGE2 secretion from a single cell and its effect on the neighboring cells. Here, by observing confluent Madin-Darby canine kidney (MDCK) epithelial cells expressing fluorescent biosensors we demonstrate that calcium transients in a single cell cause PGE2-mediated radial spread of PKA activation (RSPA) in neighboring cells. By in vivo imaging, RSPA was also observed in the basal layer of the mouse epidermis. Experiments with an optogenetic tool revealed a switch-like PGE2 discharge in response to the increasing cytoplasmic Ca2+ concentrations. The cell density of MDCK cells correlated with the frequencies of calcium transients and the following RSPA. The ERK MAP kinase activation also enhanced the frequency of RSPA in MDCK and in vivo. Thus, the PGE2 discharge is regulated temporally by calcium transients and ERK activity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
In our first CHD Spotlight episode, we'll discuss half-a-heart conditions -- hypoplastic left heart syndrome (HLHS), hypoplastic right heart syndrome (HRHS), and single ventricle hearts.Dr. Edward Bove is our expert guest. Dr. Bove spent most of his career as a pediatric cardiothoracic surgeon at the University of Michigan Health System. A graduate of the College of the Holy Cross and Albany Medical College, he went to the University of Michigan for his residency. He returned to U of M in 1985 and by 2012, he had performed 10,000 heart surgeries, mostly on babies. Dr. Bove is a long-time supporter of Hearts Unite the Globe and currently serves as the head of our Medical Advisory Board.In this CHD Spotlight, Dr. Bove explains what HLHS, HRHS, and single ventricle hearts are, what methods are used to treat these conditions, and how treatment for these conditions has changed over time.Former appearances by Dr. Bove on "Heart to Heart with Anna"Advancements in Treatments for HLHS Heart WarriorsLearning about ccTGA and the Double-Switch ProcedureSupport the showAnna's Buzzsprout Affiliate LinkBaby Blue Sound CollectiveSocial Media Pages:Apple PodcastsFacebookInstagramMeWeTwitterYouTubeWebsite
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.25.517978v1?rss=1 Authors: Shen, B. Q., Sankaranarayanan, I., Price, T. J., Tavares-Ferreira, D. Abstract: There is increasing evidence of sex differences in underlying mechanisms causing pain in preclinical models, and in clinical populations. There are also important disconnects between clinical pain populations and the way preclinical pain studies are conducted. For instance, osteoarthritis pain more frequently affects women but most preclinical studies have been conducted using males in animal models. The most widely used painkillers, nonsteroidal anti-inflammatory drugs (NSAIDs), act on the prostaglandin pathway by inhibiting cyclooxygenase (COX) enzymes. The purpose of this study was to analyze the preclinical and clinical literature on the role of prostaglandins and COX in inflammation and pain. We aimed to specifically identify studies that used both sexes and investigate whether any sex-differences in the action of prostaglandins and COX inhibition had been reported, either in clinical or preclinical studies. We conducted a PubMed search and identified 369 preclinical studies and 100 clinical studies that matched our inclusion/exclusion criteria. Our analysis shows that only 17% of preclinical studies on prostaglandins used both sexes and, out of those, only 19% analyzed or reported data in a sex-aware fashion. In contrast, 79% of the clinical studies analyzed used both sexes. However, only 6% of those reported data in a sex-aware fashion. Interestingly, 14 out of 15 preclinical studies and 4 out of 5 clinical studies that analyzed data in a sex-aware fashion have identified sex-differences. This builds on the increasing evidence of sex-differences in prostaglandin signaling and the importance of sex-awareness in data analysis. The preclinical literature identifies a sex difference in prostaglandin D2 synthase (PTGDS) expression where it is higher in female than in male rodents in the nervous system. We experimentally validated that PTGDS expression is higher in female human dorsal root ganglia (DRG) neurons recovered from organ donors. Our semi-systematic literature review reveals a need for continued inclusivity of both male and female animals in prostaglandins studies and sex-aware analysis in data analysis in preclinical and clinical studies. Our finding of sex-differences in neuronal PTGDS expression in humans exemplifies the need for a more comprehensive understanding of how the prostaglandin system functions in the DRG in rodents and humans. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.24.517788v1?rss=1 Authors: Lai, S.-f., Huang, W.-Y., Wang, W.-H., Hong, J.-B., Kuo, S.-H., Lin, S.-J. Abstract: Growing hair follicles (HFs) harbor actively dividing transit amplifying cells (TACs), rendering them highly sensitive to radiotherapy (RT). Clinically, there is still a lack of effective treatment for radiotherapy-induced alopecia (RIA). We aimed to dissect the effect and mechanism of local prostaglandin E2 (PGE2) pretreatment in RIA prevention. We found that PGE2 pretreatment reduced RIA by preventing premature termination of anagen through enhancing HF self-repair. Mechanistically, PGE2 did not activate HF stem cells, but preserved more TACs for regenerative attempts. Pretreatment of PGE2 lessened radiosensitivity of TACs by transiently arresting them in the G1 phase, thereby reducing TAC apoptosis and mitigating HF dystrophy. The preservation of more TACs accelerated HF self-repair and bypassed RT-induced premature catagen entry. Promoting G1 arrest by systemic administration of palbociclib isethionate (PD0332991), a CDK4/6 inhibitor, offered a similar protective effect against RT. Therefore, PGE2 protects HF TACs from RT by transiently inducing G1 arrest, and the regeneration of HF structures lost from RT is accelerated to resume anagen growth, thus bypassing the long downtime of hair loss. PGE2 has the potential to be repurposed as a preventive treatment for RIA. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Vidcast: https://youtu.be/GUuxYlY1pOg A multi-site meta-analysis by Australian obstetricians provided the necessary statistical power to demonstrate the superior safety profile of balloon cervical dilatation over prostaglandin drug cervical ripening. The investigators analyzed the data from 5460 women who participated in 12 studies. While use of balloon cervical dilatation did not produce a significantly lower incidence of mandatory caesarean section deliveries or adverse maternal outcomes, the babies delivered after balloon cervical therapy experienced significantly fewer adverse perinatal events. The conclusion: balloon cervical ripening seems a better option. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01845-1/fulltext #cervicalripening #balloon #prostaglandin #perinatal
Host: Parth Shah Guest: Alex Levin
A little bit about prostaglandin hormones and the effects during menstruation. The effects of prostaglandins during menstruation. Some of the things people might not realise and ways to look at the effects with more positivity. This will be particularly helpful to young people, consecrated singles / nuns and those set apart. Concluding with a prayer
A really gross question that I might update my answer to at some point...
Ein Schwangerschaftsabbruch kann instrumentell und medikamentös erfolgen. Dieser Beitrag soll den medikamentösen Weg näher erklären.
Welcome to Fun Fact Friday -- a special weekly podcast during Heart Month (February 2022). Each Friday we have been sharing fun facts for the congenital heart defect community. Our Guest is Frank Jaworski, CRNA -- he is a father to a 27-year-old single ventricle Heart Warrior and he's also Host Anna Jaworski's husband.In this episode, Frank will answer the question, "What is prostaglandin E1 and why is it important?"Special thanks to Scott Holmes Music for the song we're using during our Fun Fact Friday episode -- "Summer Fun" which you can find here: https://scottholmesmusic.com/Thanks to Pixabay for the image used with the podcast. Image by WikimediaImages from Pixabay Please visit our Social Media and Podcast pages:Apple PodcastsFacebookInstagramMeWeTwitterYouTubeWebsiteAnna's Buzzsprout Affiliate Link (we both benefit if you sign up with Buzzsprout with my link - yay!) Support the show (https://www.patreon.com/HearttoHeart)
Today, we're talking about diarrhoea. An unconventional podcast topic, for sure - but also an extremely important one. Diarrhoea affects almost everyone at some point. It's one of the most common symptoms that something in our gut is not right. In most cases it's transitory and we move on - but what do you do if it doesn't just go away? We've touched on this topic before while talking about The Athlete's Gut, but today we're taking a closer look at this all-too-common issue. On today's podcast, NBT Scientific Director and Coach Megan Hall is with me to talk about diarrhoea: the different types, the many causes, and how to fix it when it occurs. She talks about how diarrhoea is both a cause and consequence of gut (and sometimes systemic) pathologies and describes ten different things that may be perpetuating the problem. Most importantly, Megan offers specifics on what you can do to identify and treat your ongoing gut problem. Be sure to follow along with Megan's excellent and detailed outline for this episode. Here's the outline of this episode with Megan Hall: [00:01:37] Diarrhoea: why we should care. [00:02:06] Bristol Stool Chart. [00:02:54] Megan's outline for this podcast. [00:03:15] Three general categories: watery, fatty, and inflammatory. [00:04:53] Causes of diarrhoea. [00:05:00] Food triggers. [00:08:45] Tommy Wood's Highlights #2. [00:10:37] Bile acid malabsorption. [00:13:08] Genova GI Effects test. [00:14:23] Histamine; Podcast: Understanding Histamine Intolerance: Symptoms, Causes and Treatments. [00:16:22] Stress. [00:18:19] Do Simon Marshall's stress audit; Podcast: How to Manage Stress. [00:18:25] Caffeine. [00:20:18] Prostaglandins. [00:21:19] Exercise. Podcast: The Athlete's Gut: Why Things Go Wrong and What to Do About It. [00:25:45] Female Hormone Fluctuations. [00:27:38] Microbial dysbiosis or pathogens. [00:28:37] Video: Rewilding the gut - Lucy Mailing (AHS21). [00:28:59] Malcolm Kendrick; Podcasts: 1, 2, 3. [00:30:30] IBD, Croh's, Colitis, Celiac Disease, Diverticulitis. [00:31:11] How to fix the problem. [00:31:16] Remove food triggers. [00:34:13] Balance fiber types. [00:35:43] Lucy and Tommy's paper on the metabolic flexibility of the gut: Sholl, Jonathan, Lucy J. Mailing, and Thomas R. Wood. "Reframing Nutritional Microbiota Studies To Reflect an Inherent Metabolic Flexibility of the Human Gut: a Narrative Review Focusing on High-Fat Diets." Mbio 12.2 (2021): e00579-21. [00:35:58] Address stress. [00:39:02] Watch caffeine intake. [00:39:19] Prostaglandin inhibitors. [00:40:16] Address microbial dysbiosis or pathogens. [00:40:52] Supporting gut barrier function and integrity; butyrate: Tributyrin and ProButyrate. [00:42:18] Bile acid sequestrants; GI Detox. [00:43:33] Probiotics. [00:44:52] Pomegranate husk/peel: Dr. Mercola's pomegranate peel tablets. [00:46:47] Serum derived bovine immunoglobulins (SBIs). [00:48:44] Support estrogen detoxification. [00:49:14] Loperamide/Imodium. [00:51:38] 4 quadrant model. [00:55:09] Schedule a free 15-minute call with Megan or Clay.
I dagens episåd kommer Johanne en heeel time for sent til sending, men er likevel med hele tiden. Hvordan er det mulig? Flube har samlivsproblemer, fordi hun ikke har et samlig men quizdronningen Madde har råd. Lea er vikar og forteller deg om den beste måten å bruke et munnbind på! Dette vil du jo ikke gå glipp av vel? Påå gjenmunn!
As much as modern technology and science tries to alleviate human suffering, the world has been plagued by numerous health problems afflicting the lives of people. Due to COVID-19, the rate of mortality increased resulting in widespread medical and economic challenges. Our body has interferon proteins that are part of the natural defenses. They work by interfering with the virus to enter the body by activating the body's immune system. This is one of the first line of defense the human body has when it gets infected with COVID-19 but unfortunately, this is not enough. According to WHO, as of November 2021, there have been approximately 200 million confirmed cases of COVID-19. For COVID-19 medications, Remdesivir is one of the few drugs approved by the FDA to treat COVID-19 yet researchers are still evaluating which drug works best to fight the global pandemic.In this episode, Dr. Dung Trinh is joined by Dr. Ajay Gupta, an inventor and innovator who has investigated Ramatroban, new immunotherapy with potential treatment for COVID-19. Though still under development, early phase clinical trials and studies have been promising. Learn more of the potential of this medication on Episode 9!Memorable Quotes:When there's a new drug, it takes a lot of clinical trials to ensure that the drug is not just going to be effective but more importantly, it is going to be safe. - Dr. Ajay GuptaNew medications for Covid have to undergo multiple phases of clinical trials but there isn't always funding for these needed studies. - Dr. Dung TrinhOther Resources:kidneydoc789@gmail.com - Dr Ajay GuptaImportant Points:The severity of illness from COVID-19 infection depends on how the body reacts to the virus.As humans age, we produce more Prostaglandin d2 (PGD2). When infected with a virus, the production of PGD2 increases further and suppresses interferons - one of the first immune responder of the body.About the Guests:Ajay Gupta, MD is an inventor who currently develops Ramatroban, a PGD2-CRTH2 antagonist, immunotherapy for COVID-19. He is a nephrologist and basic and clinical scientist, the Section Head of Pediatric Epilepsy at Cleveland Clinic, currently the Clinical Professor of Medicine at University of California, Irvine - College of Medicine, and President and Chief Scientific Officer of KARE Biosciences, About the Host:Dung Trinh, MD is the Chief Medical Officer of Irvine Clinical Research, medical missionary with TongueOut Medical Missions, and holds leadership positions with multiple health care organizations in Orange County. He is a keynote speaker, best-selling author, and Host of “Health Talks with Dr. Trinh” which can be heard weekly on OC Talk Radio.Connect with Dr. TrinhFacebookLinkedIn
Yet another way to evict the unborn baby when it's just gotten waaaay to comfy and doesn't want to leave its home : ) --- Send in a voice message: https://anchor.fm/dr-mcdaniel/message
Today we meet Renee, a mum of two from Sydney who works as a clinical dietician. She is also the co-founder of Nurture the Seed, an encompassing guide to all things nutrition to help those going through preconception, pregnancy, and postpartum through evidence-based research and nourishing recipes (see notes below for more information).In Renee’s first birth she had a rare adverse reaction to the prostaglandin induction gel, leading to an immediate emergency caesarean with a baby who was not engaged in her pelvis. Two months into her second pregnancy COVID-19 reached our shores, and throughout it all Renee maintained a positive attitude despite some the changes this meant to her care.Renee gives some excellent advice for women in pregnancy regardless of whether they are on a VBAC journey or not. Her positivity and practical view on birth meant that despite her repeat caesarean, her journey was still a successful one.Along with the support of her primary midwives from her hospital’s midwifery group practice (MGP) Renee was able to walk away from both of her births with a positive and fulfilled outlook, thus reaching the end of her VBAC journey feeling empowered from the experience.~ Notes ~Please connect with Renee on Instagram or Facebook: @nurturetheseedWebsite: https://www.nurturetheseed.com.au**VBAC Birth Stories features women's lived experiences. It is not intended to replace medical advice. Should you have any concerns during your pregnancy please always consult your healthcare provider.Please connect with VBAC Birth Stories on Facebook or Instagram: @vbacbirthstories
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.31.231753v1?rss=1 Authors: Tavares-Ferreira, D., Ray, P., Sankaranarayanan, I., Mejia, G. L., Wangzhou, A., Shiers, S., Uttarkar, R. S., Megat, S., Barragan-Iglesias, P., Dussor, G., Akopian, A. N., Price, T. J. Abstract: Background: There are clinically relevant sex differences in acute and chronic pain mechanisms, but we are only beginning to understand their mechanistic basis. Transcriptome analyses of rodent whole dorsal root ganglion (DRG) have revealed sex differences, mostly in immune cells. We examined the transcriptome and translatome of the mouse DRG with the goal of identifying sex differences. Methods: We used Translating Ribosome Affinity Purification (TRAP) sequencing and behavioral pharmacology to test the hypothesis that nociceptor (Nav1.8 expressing neurons) translatomes would differ by sex. Results: We found 66 genes whose mRNA were sex-differentially bound to nociceptor ribosomes. Many of these genes have known neuronal functions but have not been explored in sex differences in pain. We focused on Ptgds, which was increased in female mice. The mRNA encodes the prostaglandin D2 (PGD2) synthesizing enzyme. We observed increased Ptgds protein and PGD2 in female mouse DRG. The Ptgds inhibitor AT-56 caused intense pain behaviors in male mice but was only effective at high doses in females. Conversely, female mice responded more robustly to another major prostaglandin, PGE2, than did male mice. Ptgds protein expression was also higher in female cortical neurons, suggesting DRG findings may be generalizable to other nervous system structures. Conclusions: Nociceptor TRAP sequencing (TRAP-seq) reveals unexpected sex differences in one of the oldest known nociceptive signaling molecule families, the prostaglandins. Our results demonstrate that translatome analysis reveals physiologically relevant sex differences important for fundamental protective behaviors driven by nociceptors. Copy rights belong to original authors. Visit the link for more info
On today's episode, Dr Joseph Sgroi (OBGYN) talks with Vanessa about her birth story. Vanessa's birth story features discussions around NIPT testing, nuchal translucency, amniocentesis, induction, syntocinon, vaginal birth, postnatal anxiety, braxton hicks, External cephalic version (ECV), prostaglandin.Dr Joseph Sgroi is a highly experienced obstetrician, gynaecologist and fertility specialist in Melbourne. You can find Dr Joseph Sgroi on Instagram @drjosephsgroi or his website at www.drjoseph.com.au.This episode is proudly brought to you by Tiny Hearts Education; our mission is to bring education to all Australian parents through first aid and birthing courses so they can move through pregnancy, childbirth and parenthood with confidence. Visit www.tinyheartseducation.com for more information.
Volume 11, Issue 26 of Oncotarget reported that Lung cancer is of particular importance, as it is the deadliest cancer worldwide. In this study, the authors show that high mi R-708 expression is associated with survival rates in lung squamous cell carcinoma patients. mi R-708 also represses PGE2 production by suppressing both COX-2 and mPGES-1 expression in lung cancer cells. Moreover, mi R-708 decreases proliferation, survival, and migration of lung cancer cells, which can be partially attributed to mi R-708's inhibition of PGE2 signaling. Lastly, they identify novel mi R-708 predicted targets and possible regulators of mi R-708 expression in lung cancer. Collectively, these data demonstrate that dysregulated mi R-708 expression contributes to exacerbated PGE2 production, leading to an enhanced pro-tumorigenic phenotype in lung cancer cells. Dr. Carol S. Lutz from The Department of Microbiology, Biochemistry, and Molecular Genetics at Rutgers Biomedical & Health Sciences, New Jersey Medical School, School of Graduate Studies in Newark New Jersey USA said, "Lung cancer is the most common cancer, with more than 2.09 million lung cancer cases worldwide in 2018." More importantly, lung cancer is the deadliest cancer in the world, with more than 1.79 million lung cancer-related deaths in 2018. Lung cancer is a collection of several distinct subtypes, with non-small cell lung cancer accounting for 85% of all lung tumors. mi R-708 also indirectly regulates the expression of genes involved in PI3K signaling, cell cycle progression, epithelial-mesenchymal transition, and cancer cell stemness. In this study, the authors aim to decipher novel mi R-708 targets and suggest a solution to the controversy on whether mi R-708 is an oncogenic or tumor-suppressive mi RNA in lung cancer. The Lutz Research Team concluded in their Oncotarget Research Paper that collectively, their findings suggest further study of mi R-708 in lung cancer. The data paired with previous studies highlight a potential value for mi R-708 as a diagnostic in differentiating lung tumors, as well as a potential therapeutic intervention, particularly in lung squamous cell carcinomas. Their work has identified novel tumor-suppressive mi R-708 functions by suppressing oncogenic PGE2 production through targeting of COX-2 and mPGES-1. These findings could be the foundation for identifying novel mi R-708 targets, as well as regulators of mi R-708 expression in cancer. Moreover, the study highlights the need to better understand lung cancer biology to improve the diagnosis and treatment of lung cancer, ultimately aiming to increase positive patient outcomes. Sign up for free Altmetric alerts about this article DOI - https://doi.org/10.18632/oncotarget.27614 Full text - https://www.oncotarget.com/article/27614/text/ Correspondence to - Carol S. Lutz - lutzcs@njms.rutgers.edu Keywords - miR-708-5p, miR-708, lung cancer, COX-2, mPGES-1 About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105
Oral castor oil is something not thoroughly explored in the hair loss community, despite a significant amount of promising data backing its potential efficacy. Typically, castor oil is topically applied. In practical application, its effect on hair loss prevention topically seems to be minimal when it comes to dealing with androgenic alopecia as opposed to a skin condition.…
Travis is a former collegiate team roper and bronco rider, that has found a career in relationship building and sales.Incredible science review about polyphenols vs aspirinTravis' experience and hobby with raising cattleTeam ropingThe conundrum of pharmaceutical representation vs fairness and the lawSERIOUSLY FUNNY examples of medical sales experiences, from erection pills, to pain relief side effects, to unexpected results from an experimental weight loss drug... You will love it!Nancy husband and wife may kiss the bride connectivity care whenever you need video chatting with the doctor right from your phone so I don't need stitches thank you Dr. United healthcare health plan benefits may vary helps if I need to make their morning live show I was on so that out of the mud you Mary and for Larry where is Jeff when you need him for this is the gotcha project episode number 18 I McGregor with your host Dr. Ken Brown what's happening what's going on up so the writing were already up to this is fantastic were having some great responses I'm even like bumping into people that are looking us up that's a good show gut check project canalboat we are 18 why not 18 years not quite there love my tummy.com just who had knocked it out the bag lobectomy.com/spoony check that out if you would like to get your own Arbitron teal the reason why moving so quickly today is because we've got some studies to get to we've got an incredible gas from an industry that we don't always get to represent on the show that in a course is going to be Travis page 3 of Travis page on he is a drug rep but is also very interesting upward to talk about a lot of different topics but were not to talk specifics of anything know it is to be a general just Pharma thing when I can get him in trouble now is generic company will not be brought up is generic drug won't it's going to be really neutral so there you go Travis yeah Travis will will not reveal his company and I even asked him if I can rhyme it with other words said no idle whiteboard all the guts to hold it up withhe said it won't won't happen so that's about what is a lot of stuff but one of things I do want to talk about is the stories that you had being a grubber the stories that I've had through the years in training what's going on how the drug industry is changed in like this the regulations that have been placed so it's a wild thing because I didn't realize as a young person going to the doctor with my parents what why in our small town to Gainesville occasionally was somebody in a three-piece suit sitting amongst all of the people in the in the waiting room and they always seem to be holding pamphlets and couldn't wait to get in and they didn't have to have their name on the list and they would go back but a lot of things has changed since those days and the way that pharmaceutical representatives have to become educated how they represent to the physicians how they support the positions with their staff and patients etc. so there's so want to get into in a coursers lots of others lots of funny stories to go along with having a yeah a pharmaceutical rep but yes the big news in the big news happens to be in conjunction with the KPD health box and before we forget I wanted you to touch on the feedback that you got this last week and then what you have coming out is a little there's actually an updated change so we did the box opening last week with the KB of the health box but this is a really exciting thing this is a brand-new venture for us and for member box and they did an amazing job and I've had some great feedback my patients were to make big differences you met him boxing is a primary got box yesterday we sat was Sarah Jean and were building next month's box and were making it even better because more vendors are allowing their products to be part of member box you can build your own box once you get going this is really exciting I want to personally change the healthcare landscape naturally and allow people to really start changing things about themselves this pretty awesome because some of the feedback that we got from our patient just yesterday it was scope to received her first box and she said this is amazing I don't have to guess anymore and I thought that was really awesome to have yet another new element of a patient testimony it says this is helping me be healthier and saving money, the biggest thing about the boxes once you realize that there is that study that came out the chilled 79% of the stuff that you're buying at big-box stores or the Walgreens GNC late that article came out which showed that it did not have on the label what was arching the capsules so we took the liberty of going okay you look@thingslikeexamine.com consumer labs and you make sure that things are third-party tested then you realize okay what studies have been done that have actually shown O for instance tumor does do this or trunk teal can help in different ways we get the science to back it and we vetted the products and you're able to get it a huge discount so this particular box hundred $47 for some people that's that's out of range but a lot of people are spending to 5300 on supplements and you may just be throwing it away so hundred 47 to over $250 worth of vetted supplements one of the really exciting things is one of my patients her husband passed away of Alzheimer's disease right and she he was an artist and so she took his original art and she's made cards for basically blank cards thank you cards old-school member like instead of just texting somebody hey thanks that was awesome to catch you write thank you for doing whatever will on the back of it all the proceeds go to the Alzheimer's foundation so were you put that in anybody's box so our office purchased all of her cards and were to put that in the box and I just want it's an opportunity to Cordish to share that message others diseases like Alzheimer's which are really devastating and people you will be reminded of it Mrs. original art that's being sent to restart interact on hey we can put this in your box like that's awesome thank you that is awesome and if you've ever wanted to go and use a physician's recommendation as you move through the aisles of where what supplements actually work which brands are the ones that I can trust and which ones can I save money on to accomplish all of the things that I want to to supplement mount health that's what the K BMD boxes all bouts of KB MD box.com will direct you to where you can learn more to see a video of Dr. Brown on boxing the first months box that'll be replaced here pretty soon when we basically updated and unpack month number two which was very similar to one that always has small little tweaks just to basically improve your health and you can join and you can pause at any time there was never go to the you can go to the the member store and build more build you can deftly build more he can remember boxes getting more and more products in their really and it's all you know I want do is build a box it's based on science speaking of one of our people has member box set me article this morning that I normally would really go to personal stuff here but remember you can little love my Tommy.com/spoony and get a big discount and outrun till you're wondering okay will I don't have bloating or anything like that this article was just sent to me about 15 minutes ago in the article is anthocyanins protect the gastrointestinal tract from a high fat diet -induced alterations blot within burial integrity disposal really fancy these are the molecules are talking about right anthocyanins and what they do they looked at mice and they fed them a typical high sugar high fat American diet and they demonstrated that when they did this that the mice became fat they had insulin resistance they developed steatosis which is fat in the liver and they showed despite Elsa so the bacteria got screwed up and we got then they gave the mice the same molecules that we have and are trying to fed him the same diet and it started to reverse all that process so the science is coming out on this is so fascinating so if you don't if you're not taken Toronto right now because you do not bloated you might want to do it if you're eating a typical American diet leased from the small animal studies so that's and that's in the box and that's one of the main ingredients that's only one more facet in terms of what are 20 or just straight polyp I tried to learn not it's really what polyphenols can do to enhance or protect you and your health so now we know that it works well for gut now we know that tab with that Dr. Bo tells research from the UK from Exeter that polyphenols daily for athletes actually improves performance and tissue perfusion from from blood flow in a course you slow down your recovery time all of that comes from polyphenols not to mention making your endogenous or your your normal CBD your your normal cannabidiol that you have in your body work more efficiently there's just benefits to having polyphenols in your daily diet so we built this box is a gut health box right when you start looking for science to get the polyphenols for performance you get the megastore to increase the diversity of your bacteria so that they can actually use the food that you're bringing in and then the little thing we talked about before was true see that's the micronized hydrogen to improve your VO2 max meaning that you can actually have better oxygenation these are all studies that have just recently come out and of course you get a big steep discount on KB MD CBD oil service it's exclusive to everybody he's a KPMG box number no doubt that will almost all of my patients are on our Toronto plus KB MD CBD because the molecules are trying to augment your own endogenous and or cannabinoids or in other words your own CBD that your body produces and of course taking CBD is like a insurance policy against the world because it's really get you back to balance with your immune system and your nervous system speaking to CVD so I've tweaked my back in the past several years ago a few years ago and unfortunately just this last weekend Gage was out playing basketball up in Kansas and I went to watching and I decided to go engage in a workout and I lifted incorrectly I knew better it's a it's a it's a routine I work at that I normally do but you saw this was Ronnie Coleman 600 pounds on scrub I did 550 550 is from take it easy just be safe though truthfully it wasn't that much weight but what I did I put myself in a in a compromising angle that I don't normally do is in the equipment that usually use I knew better but regardless I did get a small spasm in my lower back usually the past it would take five sometimes seven days to really get more mobility that that injury gets it's a small injury occurred Sunday and you saw me pushing beds yesterday up at the end of center and I'm not 100% but the only difference that I have now that I didn't have the last time I hurt my back from lift is it I take on trying till daily antic CBD now and I think the level of inflammation that I experienced is less now it's anecdotal it's just me I feel great today will Susan feel totally 100% let's go back to that same doing the exact same exercise injure yourself but don't take either that way we have a control group and we have a treatment group you took the words right out of my mouth is exactly what I want to do is drive back to Wichita Kansas Wichita are our lovely and nice has nothing to do that it's just five hours from here to get there so at say it's a long round trip looks like your haircut I did get a haircut and yeah several of them cut several of them I'm such a fancy place what you talking to the person that was chop in your hair I was the hairstylist that's it you you call a woman the catcher here I guess that the hairstylist was cutting my hair and she asked me use it kind of funny in the chair and I say well actually just kinda stretch my back go back I tweaked it but I'm getting better and then she went on to tell me a story about she had been rear-ended by a large truck that erection Torcon on Interstate 35 in Denton and it took about eight months to get back to where she could hold her arms up to cut hair and then you know work at home in the scissors and without feeling fatigued lots of pain so I stress it would all work that she said well I did a few things that the pain doc recommended that do it it stretches but what made the biggest difference for me is when I found a CBD that I could trust and I could take but the hardest part should try several she has rides whatever we value this all the time she said the hardest part was finding one that was reputable that she could depend on didn't break her wallet so the one that worked the best was running her a little over $135 a month and she said it'd always make it to the end of the month even though she was following the instructions on their I let her talk and it was almost like she just walked straight into what you know what it is that you do it sought his ashes what would it have made a difference if you had a physician it said I recommend this CBD because it works clinically for my patients and here's why and she said I would've done in a heartbeat if so what if I could told it would have been about half the cost of the hundred and $35 brain that you are using she said well obviously I would've saved money I would've felt better Chuck told her that KB MD she she went straight to an ordered some so it's it's it's really kind of cool that we remove the access of the cost and that of the worry of is this legitimate CBD and so there was talk about it notes the waters are being really muddied right now. His boots of there's people there's essential oil companies that outrun at CBD there's every try to put it in different things and people ordered off Amazon which right now you're getting hemp seed oil united in getting CBD right is lots of mislabeling and so I think it's really important to have something to trust same thing that you're doing and buy a supplement or make sure that your CBD use is of quality something will happen is also on the topic of that of yesterday I I like it is so Greek salad and turkey patties from from Kenny's burger which is right by my brother my office to tasty Kenny's burgers but Chef Eric said that he was with him on the show under someone holding to it here pretty soon but I was I was Artie talking some people some somewhat regulars there was I googled you and I found you show LOL my guess it's also active on the show because it googled me as a doctor but find it a joke of growth nature and that she was tell me more about the CBD and then just immediately started this whole discussion about passivity was her talk about it and then it went sideways because she goes what you talk about tomorrow Mike that's a great thing am open to looking at different articles a look at what is really interesting one that just came out about a fecal microbial transplant is not effective in irritable bowel I forget that I'm at a restaurant you said that getting said yeah out loud to your class he got real classy records. The never disconsolate that I had to explain the article on the Gladwell will so you take what you slurry it up and put it I'm sorry document can you please leave the stage and a restaurant as I know I was like what yeah okay I'm just as it doesn't get any better not go into detail about how they actually did it which is what I want to do later maybe go to a restaurant that is not does not sell more burgers is Chevron Arcana came out was like yeah let's just move you back in the corner over there and let everybody else eat the burgers no need to wash your hand yes exactly so that we talked about CBD they found us just by doing and then I got put in the corner because I have a potty mouth it's okay well yeah is about a subject hey I just a real real quick reminder for all of our listeners be sure to like and share the gut check project and then shoot us an email gadget project.com under a connector contact let us know that you like and shared we got hundreds of people over the last few weeks so we are still going to give away the signature protection package which is a combination of Tron deal and KPD CBD month supply direct from yours truly Dr. Brown so where are we on the research topic for this week Jess of Unitech before Travis Or Did You Want to Save It's for Now Save It for a Little Bit I Want to Get More into Tell Me What Happened with the Family That's Compacted in Which Delegates You Go That's Great Is His Last Big Tournament As a Yeah Is a Highschooler before He Starts Haskell Ball I Got Have One More Turn up the Rest of the Summer but They Went to What They Call a Great American Shootout It It's Basically Huge Huge Basketball for Kids Who Are in High School to College Coaches Come in and They Watching He Dent the Weekend before down in South Dallas Duncanville and Other Match of Seven in Kansas Were Were Great I Mean They They Were Challenged They Ended up Finishing Two into One Teenage Face Twice They Beat Once in the Last Two Later and but If It Was It's so Good for the Development of This Program for Them to Have That Kind of That Kind of a Set up and It's It Puts Them into a Real Game Environment and That the Boys Worked Hard so It Was A Lot Of Fun and It's Always Good to Get at Town with Any Family Member Where You're Kind of Forced to Sit the Car Talk, but As Funny Subjects Laugh So It's Now I'm Not Really Fortunate Both My Kids Did Have Good Road Trips Exactly in and You Guys Are Sit There Talking You Know He's on His Phone Now Which Due To the Lot Where They Put the IPad the Back Everything Else We Do the Same at like Whatever We Do Road Trips It's You Realize You Hate to Drive Yes but I Have Kinda Grown a Little More Fond of It Because You Gets up and Talk Yeah My Undivided Attention When My Back Was Hurt Then on the Way Back so Gage Gauges Forced to Drive and I Could Even Look down to Look at My Phone) That We Had a Great Trip and Then Abreaction Stayed in Town Because Our Youngest Son Here the Best Will Tournament but Here's the Crazy Thing You Know That I Live in a Small Town or to Such a Small Town of 5000 People Marie Was a Part of This New Concert Series It Happens Indicator That They Would Just Now Starting to Implement and They Had a Large Music Acts That Amos Tony Leroux Who Came to Downtown Decatur Will Have 5000 and Change That Claims They Live in Decatur Property Had over 6000 People on the Square Just to Watch This One… That's so ALSO They Did a Great Job of Promoting and Bring Your Buddy Downtown so It's It's like A Lot Of of Americana in Canada Trying to Revitalize the Old Square and to Bring the Community Together so They Did a Great Job of Bullets People Downtown That's Awesome That's Very Sweet so That You and the Kids Well Okay so Last Week Show so the Both Kids Were Playing in Florida for Clay's For Clay-Court National Site and so Carla Had Just like I Think the Data Redoing the Show She Just Lost It before so She Was out Luke Is Actually Doing Real Real Good He Got Six Place 256 of the Best National Tennis Players in the Country and He Was the Youngest Which Is No Problem and What Was Really Cool Is That Carla Was There the Whole Time but She's Good Enough Now That She Can Warm Lucas up so She Was Lucas's Warm Apartment Nice so Yeah so I Thought That Was Really Really Cool so Last Night so They Came in on Sunday and Last Night They Start Asked Me about the Show Which I Think Is Really Fun so Carl Goes You Know What You Say about Me Tomorrow You Might Hello Point I Would Have Been with You Which Is like I Won't Look Us up so I'm like Okay Then Something I Could Not Do Liberals Don't Ask Me to Do No No No It's Impossible Bulges Flyby and Then Lucas Others Pretty Cool Because the Last Week You're Talking about How the Weeds Grow Everywhere Yeah and He Goes I Found a YouTube Channel Called Great Big Story Just Random Stuff Is Really Well Done 4 Million Subscribers Whatever Okay There Was a Story on That He Said Talk about This So Interesting and Will Get Only Gets up Patrick's Take on a Couple of These Things but It Is a Harvard Law Professor Who Dropped out or Just Quit after Practicing Law Just Said Turned on with This Became Forager So to Speak She Became a Weed Expert Okay And She Just Goes around Collects Weeds and She Takes Them to the Finest Michelin Star Rated Restaurants in New York City Where the Chefs Do Amazing Things with Weeds and Never Last Week Were Taught about the Fact That These Weeds Grow They They Have More Seeds That Grow Were in Inhospitable Environments They Have All These Different Sure Were Probably Looking at A Lot Of Food That We Could Be Dabbling in but I'm Not Encouraging Everybody Run out and Start Eating Everything in Your Yard EE I Remember That Reverent Story Ever into the Wild Right the Alexander Supertramp Who Happen to Eat Something and He Was Bare Garlic Instead of Wild Garlic Which Was Listed on the Same Page the Buckingham Dying in a School Bus in the Wilderness of Alaska but Yes That Moving the Book Is Really Great Actually Acts and Injuring Them in a Book on My Think at the Book and the Action Was an Article in Outdoor Magazine and Then It Was Became a Book and I Became in the Movie but down What Was That We Need That You Said That You Are You Ready Okay so Yeah There so Many Edible Plants but Having A Lot Of Them Require Special Preparation There's One in Texas Called Pulte Salad And down like a Silver Dollar Weed The Problem Is Yes the Boiler like Five Times Boiler Drain It Boiler Drain and Boiler Drain It before It Doesn't Make You Sick and Ends up Just Being Another Boiled Green but My Question Is Always Point How Many Children Did You Make Sick Throat Got up I Will March Me Know Jill's Sixth Mother Let's Try To Boil More Time Drain It in and Try Again I Never like Blowfish How Many Sailors on One Ship Died. I Cut It Correctly Yeah but Having Kids Is Probably Act of Desperation Is to Find out What You Mean at Some Point You're Kind of Force You Do Yeah I Mean and Forging Is a Big Thing Now I've Been Assuring You While the Hunting Wild Mushrooms in I Know He's Actually It's It's Awesome but It's Really Scary Because I Don't Know You Know We Have from Even It Comes to Mushrooms On One of the Episodes We Had Cooper Read on the Atkins We Did a Whole Episode on How to Identify Mushrooms How They Grow Idea That's Fascinating to Me That My College Is Coming I Don't Know How in the World They Can Get That Confident I Can Think You Could Study and Study and Study but Then Suddenly You're out on Your Own Going and That Was Pretty Good Really Want You Try That Make Sure It's Pretty Good Note School Is out Is Morels Have Not There Is No Other Mushroom That Looks like Them That's Poisonous so You Want Hot Mushrooms Be Sure to Learn How to Identify Morel Mushroom and Forget the Rest And 80 Bucks a Pound It's Been Shopping for Where Do You Find Morel Mushrooms and Well All over the Place at Texas Not so Much North Texas Maybe Far North Texas Arkansas Missouri Digits Did You Know That A Lot Of Texas Mushrooms Joke in the Arm of the Supercollider There Are Going to Build Oh Yeah so That the Tunnels They Began to Build Around Here in North Texas That Quercetin Completed but There Are These Gigantic Tunnels They Had to Make That They Made Use of Them And Eight They Cultivate and Grow Tons of the Mushrooms That You Get in Your Grocery Stores in the Old You're Kidding Supercollider Tunnels Yes It's Really Awesome They Have Is Awesome That My Ankle Time I Know That Jerry and Ray They Walk in a Manner like These Big Wheels and I Mean It's like the Perfect Tank No Sunlight Environment for White Mesh Row Ever since Ever since That Episode I Become so Intrigued by Mushrooms Was Even a Netflix Special That I Watched about Mushrooms and How Prolific They Are All the Things That You Do You Know Him As You Know I'm a Big Fan of All the Research Going on with Silicide and the Micronutrients and in Mushrooms Are Me and Can't Get Them Framed from Any Other Sources It Is Amazing with a Half-Hour I'm Looking at the Time I Feel This Is Unbelievable and We Yeah This Is Unbelieving Okay so Coming up Next Generic Travis From the Generic Page Family Talking Here Outline a Cyclical Generics Is Generous Is There's There's There's It's Also Generic It's a Way to Teach You How to Be so Generic That You Will Be Invisible Will Generically Laugh Your Ass off If You Are Trying to Quit Drinking or Doing Too Many Drugs Listen to Me You Don't Know Me and Will Never Meet I Had a Problem like You Want I Drank and Used a Party a Little Too Much till He Got Out Of Control and Almost Ruined My Life I Realize I Needed Help to Fix My Problem before It Totally Destroyed Me If You Tried to Fix Your Drinking and Drug Problem and You Know You Can't Do It Alone You Need to Call the National Treatment Advisors That Will Immerse You into a 30 Day Program to Replace Your Old Habits with New Habits and Totally Change Your Life and If You Have PPL Private Health Insurance the Entire Program May Be Covered Fix Your Problem Right Now before It Gets Any Worse Get Clean Call Now and Learn More 800-296-1252 800-296-1252 800-296-1252 800-296-1252 Are You Tired of High Cable TV Rates Sign up for Dish Today and Get a $500 Bonus Offer While Supplies Last Loss Locking Your Price for Two Years Guaranteed Call American – Your Dish Authorized Retailer Now 800-570-6630 800-570-6630 – 800-570-6630 Authors Required for the Occasion 20 from Early Termination Fee at the Auto Vein Restrictions Apply Call for Details Fast-Track Student Loans Can Get Your Student Loans Out Of the Vault Stop Any Wage Garnishments Stop Collection Calls and Stop Seizure of Your Tax Refund Give Yourself a Break to Stop the Stress and Get Your Student Loan Payments down to As Little As $25 a Month Based on What You Can Afford to Pay 800-709-4395 800 709-439-5800 709-439-5800 70943950 Projects We Are Now Joined with Mr. Travis PageIs the Generic Pharmaceutical Everything That Was Brought on Correct That's Correct Okay Now We've Just Gotten Legal Permission to Show His Face That Is Not That Generic Is That Some Other Cool Stuff Going on That's How You and I Originally Met You Had These Studies Cattle They Were Doing Anything That That There Were Supposed to Tell Me to Bring the Girls Alert the Cold Court Entered an Elected Mexican Cattle Espanola Yeah I Went to His Ranch in the Rye Had Little I Little Discussion Was like Him He Stood Back to His House yet Is How We Got in Line Had Never Thought about Speaking Spanish I Don't Speak Spanish but the Mexican Guy Needed You to Come over and Help Me out with That Once We Got in Line I Was like Hey I Got a Great Idea I Hope You Want You Come to My Office and Bring Lunch Occasionally That That's How It Works Yeah That's Right. That's Really All There Is It's Almost 90s What Is What You Say 97% of Pharmaceutical Reps Started in the Cattle Industry Oh That Is It's Much Lower Than That I Hope My Way off Bad Stats in Math and so Well We Get Now That We Have Somebody from the from the Farms of the Industry We Wanted to Have Travis Calloway in on Some of the Articles That Were Going to Discuss Today and in the Science Corner From Dr. Brown so Let's so I Got It Norma What Transmittal Do Sometimes I'll Take a Really Kind of a Cutting-Edge Article and Take a Deep Dive but There's Several Different Studies That Pertain to Our Previous Shows I Just Want to Come to Gloss over Them Wanted to Let Travis Decide Which One Were to Talk about First So Very Important You May Just Pick One of Those Pages Are All Negative That Gary Sakata Description First Actually Do You Want to Hear about the Tie between the Jott Micro Biome In a Potential Way to Help People with ALS Pamela Tropic Lateral Sclerosis Is Usually Known As Lou Gehrig's Disease Stress Data Was Choice Number One Choice Number Two Would You like to Hear the Previously Discussed Kenny's Restaurant Poop Transplant Story Choice Number Two Choice Number Two or Choice Number Three Out Of a Canadian University They Been Able to Identify And Produce Molecules in This Behalf Plant That Are Actually 30 Times Stronger Than Aspirin For Anti-Inflammatory Now You Heard Eric Talk about His Back Could Be That CBD Was Doing Something Real Nice We May Have the Molecules Three so This This Is Actually More of a Personality Test For You to See Where You Actually Landed Where Where You Headlined Is Generic Travis Your Job Is on the Line Yeah I I Feel like It's a Personality Test the Number Two with the Poop Would Be like to Go to Choice One with the Got Biome ALS Biome LSO Study Just Cannot Hear with I Looked at the Motor Neuron Disease ALS What They Have Found Is That There Is a Clue That This Horrible Condition and We Had Brandon Brown on Last Week We Were His Dad Died We Went into A Lot Of Detail about the Just Slow Progression of It and You Know We've Had Other People Call in That Event Actually Dealt with Us so Is This What Killed Stephen Hawking They Have Linked Changes in the Micro Biome That Live in Our Gut so They Have Discovered That Micro Biome Will Secrete a Proper Micro Bar Will Secrete Nicotinamide Vitamin B3 And This Appears to Slow the Course of Motor Neuron Disease by Improving the Function of the Muscle Control Neurons in the Brain Now This Is Pretty Exciting Because This Is the First Time They've Been Able to Show How the Micro Biome Will Produce a Neuroprotective Molecule and What They Showed Is That They Took Some Mice and Dooming a Biotics in the No Longer Produce So When We Start Destroying and Dropping Bombs and Not Feeding Our Microbiota We Don't Produces so It Nicotinamide You Made This May Seem Familiar to You Because We Were Working with the Guys That Produce Nicotinamide Ribonucleic Acid Which Is a Precursor of This so Basically What Happens Is Nicotinamide Gets Converted to Something Called NAD Plus and This Converts Food and Energy It Repairs DNA and It Helps the Circadian Rhythm so All These Things Eventually I Want to Try Get Some NAD in Our Box Sure but so It's Pretty Exciting Because Once Again It Comes Back to the Gut Can Affect Your Brain Were All about the Got Right Axis Here And so That Was Kind of Exciting and We Should All Think before We Just Go over to Gazette about Taking Antibiotics to Eat This Crappy Food Because Your Kinda Doing Some Neural Protection Every Time You Eat Polyphenols Every Time You Improve the Diversity of Your Micro Bio/ME I Think That You Could Look at There's Two Inputs to Your Brain and and Its Health One Is the Obvious It's What You're Doing to Learn and Keep Your Your Mind Active but the Other Thing Is Just Plain and Simple You Rest of Your Body Has To Get Nutrition From Somewhere in the Only Way to Get It Eat What You Eat in a Matter I Would Just Shown Time and Time Again That the Typical Western American Preservative Filled the Diet the Preprocessed Food It's Just Destroy Your Health It Really Is We Were Seeing an Epidemic of Autoimmune Disease and Everything Else Which Is Why I Think Everyone Has an Endo Cannabinoid Deficiency We Always Talk about This There Is the Gastro Vessel System the Cardiovascular System Neurologic System Will Have an Endo Cannabinoid System I Want to Be the First Board-Certified Endo- Kanab and All Just out There I Think I Can Because I'll Have To Form the Whole John Ronald to Certify Myself Immediately to Me Interesting Residency for Sure It Will Be Really Interesting Yeah So That the Other Study Were to Talk about Which Is These Guys Figured out These Two Molecules Cannot Live in a Can of Light and Be What's Interesting to Me about This Is That They Are Flavonoids So in a Full-Spectrum Hemp These Are the Polyphenols Which Are Also Was CBD Original CBD Nobody Talk about All the Other Molecules That Come along with It We Talk about the Terpenes Which Are the Essential Oils and We Talk about the Flavonoids Which Are the Polyphenols Right And What They Showed Is These Template and a and B They Provide the Anti-Inflammatory Benefit of Taking a Full Spectrum Interesting and They Showed They Can Show This Is What's The More Interesting They Implied That They Show That These Different Molecules Are 30 Times More Effective Than Taking Aspirin by Blocking Prostaglandins Prostaglandins As Part of the Arachidonic Acid Pathway Okay yet so Just for Those Who May Not Be Completely Aware of Their Economic Acid Pathway You Start with the Prostaglandin and It Moves down I Think It's Either Level I or Level II You Get into the Cyclooxygenase of the Cox Enzyme Correct Correct and That's Where Aspirin and Those Other NSAIDs Would Work so Basically You're Saying That a Natural Flavonoid Will Stop or Prevent That That Progression down That Pathway Earlier Correct Exactly This Is Patrick He Is Just Studio Touching Things Very Range of ZZZ's Adjusting Camera Started out There So So What's Really Actually about This Is That There's No There's Big Business I Mean Back When I Was a Resident There Was Talk of a Farmer Here for Second the People Throwing the Money Out Of Us Were the Cox Two Inhibitors Sure of Who I Can't Member Who They Were but They Got There Pulled off to the Realtor Causing Heart Attacks Afflicted by Vioxx Was One of the so Just to Finish up This Article There Was Really Interesting Because I Was like Wow This Is so Cool and Then I Went These Guys Didn't Discover This in Fact It Was Discovered in 1985 That These Molecules Did This What They Did Is They Discovered the Enzyme to Produce It So They Want to Start Manufacturing Just These Two Molecules And They Probably Will Make It a Drug Sure like They Want to Do so This Is Interesting Because We Talk All the Time That the Full Spectrum Allow Mother Nature to Do Her Thing So No Offense of the Farm Industry but Frequently Though Find Something Oh There Is the Molecule during This Then They'll Manufacture It and Hope That It Works As Well As in Mother Nature but We See It Time and Time Again That It Doesn't You Need Everything in the to Do It and I Did Have Some Fun with This Because I Want on Reddit and Looked at Somebody I Recently Discovered Read about Three Months Ago Yes It Just Started Ready Friend and I'm like Reddit Thing Is Super Cool When You Find That Modems Had a Quick Side Note They Go on I Gonna Read It Funny Pretty Good Way to Start Your Day Just Looked at Cop Arresting a High a Really High Kid and I Don't Know What Happened before Goes the Cop Looks at Him and Just Goes I Mean like When They Make Fun of High People and They Portrayed in Movies You're Mad As Hell Man Thanked Its Front Page Read It for Sure It Was so Somebody Wrote Them Basically What They're Talking about Is That It's Been Known for a Long Time That These Kenna Flavin's a and B Have Been Able to Do This and the Study They Were Referring to His 1985 but It Just Kind of Implies That This Is You Know the Way Things Go What's Really Cool about It Is That There Are Potentially Thousands of Other Molecules We've Not Discovered In These Plants I Made Such a Complex Plant Which Is Why Think It Is so Many Things so That's Article Number Two Article Number Three Is I Get Asked All Time on My Patients about Fecal Transplants and so You Take Someone's Poop Stick and Somebody Else and A Lot Of My SEBO Patients A Lot about Your Mobile Patients Always Asked That Randomized Trial Came to the Conclusion That Now It's Not Any Better Than Placebo the Real Taking Someone Else's Poop Does Not Help Irritable Well Hey Just a Curiosity That Particular Study How Big Was It and Are You I Do Think the Methods Were an Effort to Be Disk and Totally Conclusive on That Element Now I'm Sure It's Not and I Don't Member Lussier Got off Public Results I'm Only Curious Because We've Seen in the past but Sometimes You Can Hundred and 75 People Recruited Okay 75 Now That Being Said It's like All Things for Me and Some Other People Would Go Ahead and Critique Us so They Took the Capsules the Frozen Food Pressure Okay Though Some Would Argue Is It You Know Is It Actually Working to Present to D Have To Go in and Do This so Do Remember Quick Side Note We A Few Years Ago We Were Interviewed We Had This Yale Gastroenterology Fellow We Took A Lot to Eat He Was Considering Joining Us and His Research Was on Fecal Microbial Transplant so Taking My so What They Would Do Is Take a Skinny Mouse and a Fat Mouse and They Would Swap and See What Happened with That Mousey Little Skinny Mouse and They Were Showing That Fat Mice Started to Lose Weight after Getting the Fecal Transplant Skinny Mice Gained Weight So While He's Telling Us This As You Can See I Have a Habit of Talk about Poop and Restaurants Yeah Our Waitress Was like What Hold on to Explain That He Goes into More Details I Guess I Will Publish This in It's Really Exciting She's like He Was Ever Thought about How Their Fat Families Is Genetics or Are They Sharing Their Poop Once You Live with Somebody Long Enough Whether You like It or Not You Sharon Poop and Just to Women with Somebody so She Just Goes Oh My God It Looks over the Water Boys like Six 420 S. West That Just Became the Sexiest Man in This Restaurant Yeah Yeah Yeah I Did So so Anyways Brigham Young University Just Came out with Actually Did a Fecal Microbial Transplant Study on Weight Loss The – Documents and so Is Small Study but It Actually Did Not Show That Improved Weight Loss I Had a Patient That Did a Microbial Transplant from Her Sister and She Ended up Getting The Same Diseases As Her Sister Though She Developed Acne and Hypothyroidism and Put on Weight It's Really Interesting Though Because I Think It Even United Whenever That Study First Came out from Brigham Young That Was That There Probably Are Still Some Environmental or Extrinsic Controls That There Probably Weren't Measured Because Did the Fecal Transplant Actually Have Number One Time to Change the Habits of the Desires the Person Had Now It Seems like There's A Lot Of Different Facets Whenever You're Talking about Essentially a Human in the Wild of the Western Civilization and And All of the Different Offerings That You Can Have for Food Sources Etc. Can Be Reversed So I Thought from a Generic Farming Nice Yeah so I'm in a Really Have To Not Beating in My Scene To Ingest Somebody Else's. Psalm Tanya Seems like There Would Be A Lot More Negative Than Positive to Write Well Will I Think That There's so Much Science Coming out on the Micro Biome We Don't Know What to Do with And There's A Lot Of People Who Are Really Desperate I Think You're on an Island I Think Most People Are Totally into Having Someone Else Do You Think That We Took a Poll I Don't Know It See This Is What He Brings up a Good Point Maybe My Sample Size Is Way Too Small Maybe I Need to Ask More People Than Just Myself Okay That Was No Pun Intended Right Your Sample Size I'm Glad Someone Is Picking up a Ladder Right after L Phoenix on Friday Obviously Travis Does Not Work for a Mixed Good Restaurant Is Awesome Yeah but No It's Believe It or Not It's a Topic of A Lot of Scientific Inquiry Right Now Yeah Microbial Transference the Microbiota What's Going on I Mean This Is People Not Ever since the Advent of the Phone I See More Pictures of People's Poop and I Don't Need to Just Keep It Right There Don't Know What You Can I Got the Good Imagination I Imagine That Is Interesting No and We Did Get Asked about That Quite a Bit at the Procedure Clinic About What You Know about Fecal Transplants but I Think There's Still Time Left to Discover If It's Well so It's the Brakes of Been Put on It Because Just Recently That Study, We Have People Died Two People Died from Getting a Fecal Transplant Because the There Was a Bacterium That Yeah That's What I Was in Salmon There's That Negative Outweighing the Positive Right Because There's so Much Negative from Its Waste Right I Will yet so Technically That's True but That's It Has Your Micro Biome and It Has A Lot Of Dead Things Is a Ton of Waste in It and You Know Poop Is Extremely Complex We Don't Really Quite Understand What to Do with It or How to Make It Better but We Do Know That Your Micro Biomes Your Genome within Your Genome We Need to Start Treating That Accordingly Give It What It Wants You Start Having A High Process with High Sugar Food You're Going to Have Bacteria That Are Going to Proliferate More I Will Start Sending Signals to Your Brain to Ask for More of That so Are You in Control Or Is Your Bacteria in Control of You That's the Interesting Thing Yeah Definitely Has Many Other No Words No That's That's We Just Waited Technically for Quick Studies Today NL Just Came out but Right Now I Got I Got I like Commit to One and Do a Deep Dive on It but We Were Able to Come to Cover the Cover Basis Rather While They Want to Gain It Well Travis Walking the Show Thank You Ashram so You Were Born in Carrollton Texas Correct Yes and Currently Now and of Course We All Teasing but We Can't Worried Asked Not to Totally Reveal Exactly What Farms It Was a Represent What Company That You with but That Won't Prevent Us from Talking about the Journey to Get to Where You Are Now so It Will… Let's Go Ahead and Cleverly Were Microfiber but the Reality Is Is That the Pharmaceutical Industry Has Been under Fire for the Last Decade or so Though Sure That the Regulations What Can Be Said What You Can Be Represented Have Really Been Ratcheted down in Some Part of the Fun I Want to Do Today's Talk about My Journey As the Doctor Where There Was No Limit Free-For-All It Was a Free-For-All to Now Would You like to Know You Can't Say Anything And I Can't Bring You Anything and We Can't Do Anything and Everything's under Tight Regulations It's Morphed A Lot I Mean Definitely over the Last Three Decades It's Probably Not a Recognizable Profession When It Was 30 Years Ago Compared to What Is Now Yesterday There's a Guy That That Worked with On the Primary Care Side That Will Just Call MAC Outright and He Was 60 Something Years Old He'd Been through He Made It through like Eight Different Layoffs over The Course of His Career Right Me Just Could Not Kill This Guy And He Was a Fixture Every Wednesday He's in This Particular Office Right and I Just Asking Him and Talking to Him about What The Industry Was like 30 Years Ago When I Came into It I Mean You I Missed out on On All of That Right and You Know It's It's the Only Sales Job Really That I Can Think of Where It's Not Okay to Take Your Customer to Dinner or Take Your Customer out for a Drink or out to Play Golf or or Whatever the Scenario Might Be I Mean Yeah One of My Best Friends Is His Family Owns a PVC Pipe Manufacturing Company Right They Live on That They Live on Entertaining Their Customers I Mean It's Expected Brian and I Is Not Funny Because Doctors Now Are so Scared Especially with Happen to Some Hospitals Doctrine Hospitals the Stuff That If You Own It If You Do Anything in Medicine I Do Not Want I Don't Take Any Money from You I Do Not Want to I Feel like a The High-Level College Recruit Just like Now What I Will Pay for My Own and Because He Is There so Much Fear on the Doctor and Roots like Look at You Being Influenced And the Reality Is There Was A Lot Of Money to Influence People's Behavior and That's What That's Why the Relations Came around His Right Is Wrong I Don't Know While Internet and That All of the Training and Everything You Get Is a Rat Now Is All Very Patient Focused Right It Is It Is All about Presenting a Case and Paying a Picture of a Particular Patient That Needs Help And That That's Really Our Job at This Point Is to Go Get in Front of the Physician Somebody Has the Capability to Improve Somebody's Life Right by Writing a Prescription or Doing a Procedure Whatever the Case May Be in Just Painting a Picture of the Patient That They See on a Daily Basis but Maybe Get Lost in the Shuffle Are That They Don't Recognize and Try to Paint a Picture of How That Patient Suffering and How You Can Help So I Mean I We Will See the Company Name but I've Been Doing Clinical Research for A Lot Of Different Pharmaceutical Companies and I Work A Lot Assigned to Place on Sears Has Some Really Smart PhD's That a Return to Work This out so There's There's All Different Kinds of Views of What This Industry Is and What It Was What It's Become And Everybody Insurance Companies Have a View of That the Patient Has a View of That the Doctor Has a View of It the Company and There's so Much So Many Moving Parts That Are Continually Moving so If a Drug Company of Or Research Division of the Drug Company Has a Pretty Good Product If It Doesn't Look like It's Gonna Be a Homerun There's Just a Recent Pharma Startup Were There Looking at Something in Cannabis in the Phase 3 Clinical Trial Was Looking Bad And Somehow It Got Leaked Their Stock Plummeted 81% On This The Rumor That the Trial Wasn't Going Well It's Crazy Because He Almost Are Stockholders in Industries like That You're Always Betting on the Future It's Never on the Present Value of What Merely Delivering a Good Service Would Heavy It May Have so Much Weighing on That in Fact If Armor the Number Correctly You May Be Able to Correct near It's Probably Grown since Then but the Late 90s We Were Told the Stat And That Was That so Much of the Money in the United States Of America Pharmaceutical Industry Is Strictly to Stave off the Costs of R&D and the Elements That Go into That to Move That Product Soaked over Told Is That before One RX Is Sold of Any Doesn't Matter All Comers Is Sold That over $1.4 Billion Had Been Invested Industrywide to Create Good Multifarious Trials the Experiments That the Development Of a Said Drug That Would Come with Every Lineage You You Yourself Even Said They Had That Started with a Steady Back in 85 and Now They're Trying to Find an Enzyme to Do Something Will Were 30 Years Removed from That so over That Time How Many People Spent Time Reading That Article so This Is an Aggregate of All of the Time and All the Research That Goes into This and Avenue Where We Can Improve Either an Outcome or What Have You Is Just A Lot Of Money on Top of That Before You Can Turn a Drug out to Somebody You Gotta Go through At Least Three Phase Clinical Trials and Then Moving to the Force Where the Consumer Will I Will Say This Travis Are Here Because Number One Your Atypical for a Drug Rep So How in the World like What Your Journey Man Were to Start College and Appear Yes so It It's It's Really Not That I Complicate Our Plan to Be Here A Lot Sooner Than That I Was a Mean on That Third Show Doesn't Start until I Was Right on Time for That Yes so You Are Talking about My Journey Right so I'm a Third-Generation Sales Guy When My Dad Went through School When He Came out It Was All about Computer Software and Hardware Right When I Was in School It Was All about the Pharmaceutical Industry and so It Was My Ambition Right to Be in Sales It's All I've Ever Done Don't Care If It's My High School Job My College Mates It's Always Been Involved in Sales so I Knew That's What I Was Going to Do in the Hot the Hot Job to Have Come You Know Back in 1999 Was Coming into the Pharmaceutical Industry and It All Went to a Small State University Which Was Mistake Right Great Experience Great Education but Just Not Allowed A Lot Of Alumni Support Board Job Right after You Get Out Of School You Know When and at That Point I Thought I Was Going to Be a I Thought It Was Going to Be a Pro Athlete Right Because We All Do When Were 18 or 19th And so When I Discovered That I Wasn't Going to Be Right I Try to Get into That the Job Market Will Sports So I I I Rodeo Road in College and You Know I Thought That That Was Going to Be Realizing Your Second College Rodeo Yes Scholarship Person That We Got on the Show the Odds That's Where I Show 18 We Had to Know Me That's the Elementary Him Percent Yeah Hendrickson Was a Rather One Robo That's Right Robo So What Would He Compete and What Was His Mostly Bad Ass Surrey Samurai Night Was That He Was a I Think He Was a Bronc Rider It Is a Professional Bronchitis Think He Was a Bronc Rider Yeah Yeah Yeah so That's What I Did but There It Was Very Evident That I Was Not Going to Be Professional at It by the Time I Arrived National Rodeo Person Liquid of the Skills and the Acyl Basically Your Your You're Willing to To Put Your Money Forward and Go on the Relative Absolute Zero Sensitivity in the Mail Nether Region There's That Your Behalf Shopping to Play Smudges As People Think That It Is That Often so We Don't Have To Worry about Being Somebody Runs up and Just Kiss You All of the Terry A Lot Of You A Lot Less People Sign up If That Were the Case Yeah No I Mean It's It's Really You Know It's It's It's One of the Few Sports in the World Where There's No Contract There's Nobody Paying You Unless You Went so You Gotta Be Able to Foot the Bill to Go Compete And Then Yard You Know Basically Sustaining Yourself with Whatever You Went so If You Don't Win It's Not Sustainable Is Basically What the Deal Is so That the First Job Interview I Had a College Was with Copenhagen's Goal Right Okay and so I Go down to the Office There in Louisville Used To Be on Main Street There in Louisville and I Go in There and I'm Talking I'm Talking to This Gentleman and It's a Sales Job and Ides Promotional Job and I Get to Go on the Road All These Rodeos and Stuff and Promote Copenhagen's Goal Might Man It Sounds Fantastic I Said so How You Guys Health Benefits Magazine That We Don't Have That We Pay like 70 Company I Mean Yeah Yeah Your Initial You Will Take Jobs Coming out You Have To Eat so Did You Have Any Issues Taking a Job That Actually Is Harmful To Society yet so in When You're 18 or 19 It Are More Associated with Cowboy Than I Did It Measure Harmful You Know and As You As You Grow up and Mature You Realize That That's Not a Great Thing You Know What I Mean but an 18 or 19 I Just Associated with Being Able to Be Look at How You Look at Look at the Advertising They Were Doing Then It Is Sex for for Your for Your Peers That's Sexy to Be Doing Copenhagen School Started to Happen When I Was 14 Years Old I'm 42 Today Today State Not Today Matt How Is Patrick and with Everything. I Wish It Was My As Long As the Mud Pie We Yeah so Know They Definitely Marketed on the Old You Your Walt Garrison Everything I Mean You To Be What You Had Done to Dip Snuff You Know At Least I Thought That When I Was You Know in Middle School You Know What I Mean so Yeah I Would Not I Would Not Do That Today God's Blessing Because Now You're in Your Center Help to This Said Again Your Products Help My Patients so You Come Full Circle without Definitely and That's It That Is That Is the Most Gratifying Part of of What I Sell Is That You Don't Unsolicited Patients Will See You in a Waiting Room and With This Particular Product That I'm Selling Now at Mean It's a Lifesaver Right so like Literally so Patient Comes up to Me This Is Not a Month Ago In the Waiting Room and Says You Thank You for Doing What You Do You Say My Life I Can Save Your Life Right but It Makes Me Feel Good to Think That I Know Made a Case for That Patient Advocated for That Patient in Front of Physician That Ito Saw Fit to Put This Patient on That Product and It of Their Life Is Improved Because That in Some Dramatic Way so That's the Big Deal with Travis That Was Ablated Not You Just Did Your First Half-Hour with Us on the Guttering Project We Have a Whole Another Hour to Go with Travis We Got Tons of Really Cool Stories about the Pharmaceutical Industry Will Be Back Here in Four Minutes This Is the Only 24 Hour Take Anywhere Platforms Dedicated to Food and Fun We're Spooning Our Townhall.com, Is a Thing or Two about What It Takes to Succeed in National Politics and President Frump Believes the Russia Probe Will Hurt the Democrats Politically in 2020 President Is Predicting That the Democrats Focus on the Russia Investigation Will Backfire in Next Year's Presidential and Congressional Races after Former Special Counsel Robert Muller's Congressional Testimony the President Said There Was No Defense to This Ridiculous Hoax Greg Claxton the White House Horace Johnson Vowing to Silence What He Calls the Doubters the Doomsayers the Gloom Steers You Don't Think You'll Be Able to Successfully Lead Britain Out Of the European Union The New British Prime Minister Is Held His First Cabinet Meeting Later Address Parliament Johnson Promising to Exit the EU by the End of October North Korea Has Fired a Couple of Short Range Missiles into the Sea off Its East Coast South Korea Says One of the Two North Korean Missiles Flew 450 Miles Longer Than Initially Suspected Soul and Set Both Missiles Got to That Distance before Landing in the Walters of the Country's East Coast the South Categorizes Both Missiles a Short Range but It Concerns As to Their Status Senior Japan Official Says If They Were Ballistic Missiles They Would Be Violating UN Sanctions on Charles the Ledesma Party Time in Puerto Rico Protesters Celebrating Afterword That the Embattled Islands Governor Will Resign a Week from Tomorrow Led by Strong Demand for Commercial Aircraft in Cars Durable Goods Orders Rose by 2% Last Month on Wall Street This Morning Stocks Are Lower the Dow Is down about 138 Points the NASDAQ Composite Index All 58 S&P Currently down 14 Points More on the stories@townhall.com Now You Can Fly Anywhere in the World and Paid Discount Prices on Your Airline Tickets Flight Today to Learn This Harassment to Read or Anywhere Else You Want to Go and Pay A Lot Less Guarantee Quality International Travel Department Right Now Low-Cost Airlines 800 452 1075 800-452-1075 That's 800-452-1075 Got an Old Car Donated Whether It's Running or Not to the United Breast Cancer Foundation and Save a Life They'll Even Come and Pick It up for Free The United Breast Cancer Foundation Has Saved Hundreds of Women's Lives through Their Free or Low-Cost Breast Screening Exams but Now They Need Your Help The United Breast Cancer Foundation Wants to Save More Lives through Early Detection by Offering Women Free or Low-Cost Breast Screening Exams In Donating Your Old Car SUV or Truck Whether It's Running or Not Helps Pay for Them Plus You Get a Charitable Tax Deduction Help the United Breast Cancer Foundation Save Lives by Donating Your Old Car SUV or Truck Call Now for Free Pickup 800-245-0823 800-245-0823 800-245-0823 Call Right Now That Number Again Is 800-245-0823 Never Forgotten Apparel Is More Than Just a Premium Women's and Men's Clothing Line It's a Movement to Remind Us to Where American-Made and Serve Those Who Serve Us Our Heroes Never Forgotten Apparel Gives 20% of Their Total Sales to Nonprofits That Support Homeless Veterans and Off-Duty Firefighters and 50% to Individual Veterans and Firefighters in Need Nationwide Checkout Never Forgotten Apparel.com Use Promo Code Matt and ATT And Get 15% off Your Purchase Will Go Back into Our Number Two Check Project Episode 18 on Their Clear Here with Your Host Dr. Ken Brown in the Course Today We Have the Generic Pharmaceutical Rep Travis Page Real Quick Don't Forget to like and Share Gut Check Project Go to YouTube.com Search Gut Check Project Then Be Certain to Subscribe and Tell a Friend Then Go to Get Check Project.com Go to Contact or Connect Let Us Know That You Did It to Be Entered into the Contest Where This Month Next Week We Give Away At Least Five Signature Pack 10 Troubleshoot the Signature Packages I Have Heard You Talk about This but It Is Change the Time Two Cans of Copenhagen's Good for Your Patience I'm Glad That's Better Than That to Be Month Supply about John Teal and Katie Being CBD Paired Together and You Get to Choose Your Flavor like Natural Natural like Sentiment Gets in So It's, like Opening You Choose Your Flavor Yeah Yeah Signature Package, like Copenhagen Be Sure That Is Now like Travis Are Coming on Your Great Salesman Genesis I Was of Delta Here Is a Reminder Ever since the Invention of the of the Phonathon Wonders for My Hemorrhoid Business and That's Why so This Is My Public Service Announcement Don't Red and Poop Because You Get Him Yeah That's Public Service Announcement How Does like the Fact That Friday Nephrology's Toilet This Is Weird That's Gutsy That's Her Mascot Yeah It's It's Cool That He Can Also Articulate His His Hand to a Phone and He Uses the Potty but Now It Away This Is What Amphibians Do Nowadays This Is with Her into Everybody's Evolving Everybody Is Evolving See Evolving so Tribes You Had Quite a Change from You Went to If You Had Mentioned Earlier That Lady Said He Went to Stephen F Austin Kratz Yes Sam Foster State University down in Nacogdoches or East Texas and Currently Now You Live in Crom Which Is Just West of Denton Texas Correct Correct and You Did Not Leave Your Team Roping Skills behind Is Part of Your History You Just Lunch Would Expand on That You Have Any They Do That Anyhow Yes so That in Our Roadblocks in College and We Always Thought That the Timed Event Guys Are Kind of the Sissy Guy I Know I Just Turned out They Were the Smarter Ones Right It Really It Really Does Turn out That Away You Know Your Your Career Is Is Prolonged Quite a Bit You Know When When Your Mount Is Not Trying to Put You on the Ground Hurt You You Know so It It Was Very Much Considered to Be and an Old Man Type Thing by the by the Rough Stock Guys Will Now I Fit That Bill Right Side Zero Shame about about Team Opening It's Actually Extremely Complicated and I'm Rude I Learn Something New Every Time I Go about so It's Some Guys Fish Some Guys Play Golf on Llama Pharmaceutical Rep by Trade but My Hobby Is Timo Days a Week Do You Do T-Mobile or Do You Work on It Yes so It's It's Tough Right Because of You Know All the Resource That You Need to Actually Practice Something I Have You Know What a Dummy If You Will That I Can Roped It Stationary That I Can Do by Myself All the Time but to Actually Get Rigged up and Get on a Horse in and Have a Live Cattle the Rope for Me Not to Be Someone You Have the Cattle Strictly Roof Yes so This We Just Built a House Last Year But before That I Was on a Real Property That Actually Had the Facility A Roasting Pan on It and so We Would Bring Cattle Lisa Basically to This Facility but We Have A Lot Of Space Sure so You Go Online You Start Trying to Leave Lease These Corian Take Cattle What They Want to Lease 100 up We Have Space for 100 Right so We Needed 5 to 10 Generally Be Whole Lot Easier If He Had the Hundred in That Same Space and I Was Going Fishing in Lake Geneva Was Starting Okay That Would Get Really Complicated in a Hurry Bill out Would Be A Lot Of Moving Parts Anyway since We Figured out That You Know There's a Market for This Bird You Know the Small Group of Cattle so My Idea Was on My Little Place to Raise Five and There's All These You Always Have Five Babies on the Ground That Would Mature and and Be Able to Be Leased out to Somebody's Facility and You Drive up down 380 You Know You're from Decatur You Know What I'm, There's All These Little Farm and Ranch Is There and A Lot Of Them Have Team (so That If You and and and Their Alts Smarter Not Hundreds of Acres Right There There 8 to 10 so Not A Lot Of Space to Keep a Bunch of Cattle so That Was My Idea so I Got And Just like Everything Else I Get Myself into a Little More Complicated Than What I Thought You Know It's A Lot Going on This for like I Think Is My Fourth Year and Raising the Yeah Yeah so I Started out with Two Mama Cows in My Idea Was to Breed Him and Then Turn out Babies Will Eat You Can Only There You Can Only Keep Him Permanently If Their Female Right Because That's the Only Way to Make More Cows Right Is to Have Female so If You Have Males That Doesn't Grow Your Herd You Know What I Mean You Can't Bring Them Back to Each Other and I Can't Think so It It's Been an Endeavor Right so Were in the Were in the Process but Yeah That's Another Aspect of the Hobby I Guess You Have like a Career in the Dating Apps with the Yeah Yeah What Side of the Body Corian Table down the Road so You Know Every Every Winter I Take Him on a Date Hello Demo Gals in the Trailer We Take One or On a Day over in My Buddy's Place Even for Them Swipe Right around and Only One so That They Are A Lot Of Choice on a on a Quick Side Note We Talked about This before That When You Have Too Many Choices There Is a Psychologist That Did a Site Psychological Study Were People Who Chooses Many Types of Jams That They Wanted and Had like 40 Different Kinds but You Could Bring Her Back Didn't like It or They Could Choose between like Three And He Showed That the People Had More Choices Were Less Happy with Their Choice or with Their Decision and the Other Ones Didn't That's Exactly What I Think Data Gaps Are I Think You Should Download an App and You Go One of Two Choices That Are You This Guy like That You Pick It and I Think People Would Be Happier Person I Don't Have Any Experience with It so That All I Not One Time Have I Ever Had It I've Always Had You Insane the Natural Old-Fashioned Way Right so I Don't Even Know What This Means This Online Anything I Don't I Don't Get It Never Participated in Also You like Me Look like like the Old Way like like OkCupid Original Apps like I See You Are and You Always Are I Say Something Funny You Know and Then We Dance and Then We Have a Beer and That's It L Next Week and We Go to a Movie like a Real Relationship But I Guess This Is a Real Thing Will Go My Point Is How Unhappy People Are And I Think That Deserves That Foam Well There's Always a Sphere of Zero Something More to Be like You Could Choose You Driving down the Elders Bolted Usually with That Will Make Better You Know Kids with This Was the Swear That That's an Interesting Concept What If If Back before Social Media If People Think of Everything You Give up to Put Your Profile on a Dating App May Not Only Do You Have How You Aesthetically Look but You Begin to Say Your Name or Your First Name out I Assume Sometimes I Do They Ever Ask If You Giggle the Deeper What Your Occupation Is WikiLeaks Which Hobbies Are but If You Just Had to Wear Shirt Just Said Your Name And Then Your Hobbies Where You're from And like What What Area You Live in and Then You Are in a Bar and Then You Begin to Weed out People before You Ever Got to Know Them Just Based on What Their Hobbies Were Never Printed on Their Shirt They Would Bay It Would've Made Things Just a Dating Shirt When You Compare the Hobbies of Everybody and There Probably Not Be Satisfied with the Fact That You May Not Find Somebody like Team Roping And It Just Because It Wasn't Listed on There so the Promo Comes from Looking at All This and I'm Not Seeing My Hundred Percent Match Here If You Have These Small Biographical Details but They've Done I Mean There's a Whole Lot of Evidence We Are Not Becoming Happier As a Society Affect Depression Is This Huge Which Is Why Think Things like Sulci but I Can Make a Big Difference Probably All These Drugs and Everything Probably Just Putting the Phone down for a Little Bit Is a Great Way to To Reconnect and Reset Which Is What I like about What You Do Is Your Hobby You Your with Nature Your Beer Interacting That's Awesome Well in That You Know the Contrast Is My 11-year-old Son Just Turned 12 He's 12 Years Old Now but Now He Is So Not Interested in That Aspect of My Life and When I Was Growing up What a Kid Because I Didn't Have It You Know What I Mean I Ate Was All Indirect It Was Adjacent to Me Was the Influence Was All for My Mom Side of the Family But It Was Everybody a Kind Move past It so I You Know When I Got into It I Can I Got into It on My Own so I Would've Loved My Dad to Be Involved in Something like That and My Son He's a Baseball Player This Thing This Is Not but He'll Pick up the Phone All Day No Enemy Ill Be on That PlayStation but You Know That's It's Just Completely Different from When My Experience When I Was Growing up Totally Can You Explain Exactly Were Saying Team Roping You Know I've Never Watched It I Don't Know Just Tell Me What You Do Okay so I'm on That I'm on the Head Side Right so It Set up This Away There's A Shoot in the Middle Where the Callous Deployed Right in on Either Side I Shoot There's a Box so the Cows Deploy to Get a Head Start Right and Then It's Basically a Horse Race Right so the Guy on One Side Is Responsible for Roping the Horns the Other Guys Responsible on the Other Side for Coming behind and Roping the Feet And Then yet You Dally off Your Saddle Horn and Kinda Stretched Tight for a Split Second They Drop a Flag Not Your Time so It's a Time to Vent Animals and Hurt Not at All Not at All Not All Yeah so There's A Lot Of Controversy Sir Surrounding What They Call Tiedown Roping Where They Use Sprite with a Flip Them over so There's a There's A Lot Of Controversy and Not Just the Way It It Looks I Think Team Roping Is A Lot Less Shocking but You Know That the Bottom Line Is Is That There's All Kinds of of Regulation and That Kind of Thing to Make Sure That That That the Animals Are Taken Care Of and I'm Telling You This Those Horses I Would If I Could Come Back Is on My Want to Be High and Horse Absorbed a Performance Horse of Some Nobody Lives Better Than I Did Have a I Had a Friends Family That They Bread over the Cold Cut Horses Big Big Big Money
SHOW NOTES: In this episode, I'm touching on the differences between Vegan and Cruelty Free Beauty, discussing the dangers of chemical eyelash growth serums and sitting down with Luna Nectar founder, Mia Kut to discuss her non chemical alternative. VEGAN VS. CRUELTY FREE 1:40 1. Vegan doesn't contain animal ingredients 2. Vegan doesn't mean free from animal testing 3. Many Cruelty Free Brands offer Vegan Options 4. Cruelty Free must be not contain any products or ingredients tested on animals 5. Required by Law Animal Testing YOU PUT THAT NEAR YOUR EYE? 8:16 1. Chemical eyelash growth serums contain prostaglandin analogue - a compound that signals inflammation 2. Chemical Eyelash serums cause chronic and irreversible dry eye disease 3. Prostaglandin analogue is used in glaucoma treatment 4. Inflammation thickens the oil that provides the eye with moisture and clogs the glands. 5. Many over the counter serums contain a synthetic version of prostaglandin analogue isopropyl cloprostenate and claim to have no active medical ingredient. The synthetic version causes the same damage. INDUSTRY CHAT WITH MIA KUT 14:17 *Starting out in beauty 15:38 *Naming Luna Nectar 16:18 *What is vegan beauty and why it is important 16:56 *The Luna Nectar product line 18:51 *Jade rolling 21:45 *Where to find Luna Nectar 23:20 *Her desert island beauty product 25:13 RESOURCES: Glam Latte Youtube Channel Luna Nectar Luna Nectar on IG Logical Harmony Cruelty Free/ Vegan Resource Information on the chemical eyelash growth serums WANT MORE? Become a MEMBER! Get exclusive content, bonus episodes, behind the scenes looks, makeup mailers and so much more. Click here to join! Give us all your questions! DM on the gram, or Hit us up on FB or Twitter or join the Facebook group!
The Immune System protects the body from foreign substances, cells, and tissues by producing what is referred to as an immune response. Listen in as Christine and Jimmy discuss this vital functionality of the human body and how to help it help YOU stay as healthy as possible! Welcome to The Nutritional Pearls Podcast! Focusing on topics that include digestion, adrenal fatigue, leaky gut, supplementation, electrolytes, stomach acid, and so much more, “The Nutritional Pearls Podcast” features Christine Moore, NTP and is hosted by Jimmy Moore, host of the longest running nutritional podcast on the Internet. Sharing nuggets of wisdom from Christine's training as a Nutritional Therapy Practitioner and Jimmy's years of podcasting and authoring international bestselling health and nutrition books, they will feature a new topic of interest and fascination in the world of nutritional health each Monday. Listen in today as Christine and Jimmy talk all about the importance of a strong immune system in Episode 17. Here's what Christine and Jimmy talked about in Episode 17: 1. Definition of the immune system: protects the body from foreign substances, cells, and tissues by producing the immune response. 2. Three lines of defense A. Nonspecific Resistance/Barriers 1. Mechanical Barriers a. Intact skin b. Tears c. Mucous and mucous membranes d. Saliva e. Cilia f. Epiglottis 2. Chemical Barriers a. Skin (perspiration) b. Gastric juices-hydrochloric acid with a pH of 0.8 to 3 c. Lysozyme-an enzyme capable of breaking down cell walls of various bacteria. It is found in perspiration, tears, saliva, nasal secretions, and tissue fluids B. Nonspecific or “Innate” Immunity-white blood cells provide a rapid response to a wide range of invaders. Think of this as your surveillance system C. Specific or “Adaptive/Acquired” Immunity-white blood cells mount attacks on specific invaders that escaped the Resistance/Barriers and Innate Immunity 3. Things the Immune System includes A. The Thymus-helps develop T-lymphocytes or T cells which is an important type of white blood cell used in fighting infection B. Spleen-helps filter the blood for the immune system. Red blood cells are recycled here; platelets (a small colorless disk-shaped cell fragment without a nucleus, found in large numbers in blood and involved in clotting) and white blood cells (less technical term for leukocyte which include lymphocytes, granulocytes, monocytes, and macrophages) are stored in the spleen. The spleen also helps fight certain kinds of bacterial infections that cause pneumonia and meningitis. C. Lymph Nodes-they are small bean-shaped structures that stores cells called lymphocytes (a type of while blood cell) that fight infection D. Intestines-our intestinal tract contains 60% of our immune system E. Bone marrow-produces red blood cells (carries oxygen throughout the body and removes carbon dioxide from the body), platelets (involved in clotting), and white blood cells (help fight infection) F. Macrophages-a large white blood cell that can locate and eat particles like bacteria, viruses, fungi and parasites G. Lymphocytes-produce antibodies to destroy cells that might cause damage 1. B Cells-create Y-shaped proteins called antibodies and are developed in the bone marrow 2. T Cells-kills cells that have already been infected by an invader and are developed in the Thymus 3. Natural Killer Cells-composed of innate immunity and are responsible for helping to fight tunours and cells that are infected with viruses H. Antibodies-blood protein produced in response to and counteracting a specific antigen (a toxin or other foreign substance that induces an immune response in the body, especially the production of antibodies) 4. Types of pathogens A. Bacteria: completely independent, able to eat and reproduce quickly (can develop into millions of cells in 4 hours) B. Virus: 1/1000 smaller than a bacterial cell, not alive, attaches to a host cell and injects its material into that cell and uses the genetic material to make new viruses-the host cell bursts and releases the viruses C. Parasites: 1. protozoa-are one celled organisms like Giardia (a type of infection in the small intestines usually contracted by eating contaminated food or water) and Malaria (invades the red blood cells) 2. Worms-like Pinworm (small white worm whose eggs can be inhaled through the air or consumed through food) and Tapeworm (a flatworm that lives in the intestines and consumes nutrients that have already been digested) D. Fungus-plant-like organisms, many are useful and edible (mushrooms), some cause problems (Candida), and there are over 100,000 species of fungi like yeast and molds 5. Good digestion is critical for good immune function A. Proper stomach acid is needed to digest and absorb nutrients needed for good immune function B. Proper stomach acid is needed to digest the proteins we eat so the poorly digested proteins don't irritate our intestines leading to Leaky Gut and Autoimmunity-60 to 80 percent of our immune system is in the intestines. A decrease of good gut bacteria always leads to in increase in harmful microbes because it reduces the amount of good bacteria that can fight the bad bacteria C. The liver and gallbladder need to be working well to digest and break down the fats we consume (fats are needed in Prostaglandin formation which helps control and regulate inflammation) 1. Prostaglandin 1 or PG1-comes from Omega-6 fatty acids which are anti-inflammatory in nature A. Pumpkin seeds B. Raw sunflower seeds C. Pine nuts D. Pistachio nuts 2. Prostaglandin 2 or PG2-comes from Saturated fatty acids which are inflammatory in nature; inflammation, in this context is good because it allows the body to create a pathway for the immune system to do its job. A. Full fat dairy products B. Fatty cuts of meat like beef, pork, and lamb C. Lard 3. Prostaglandin 3 or PG3-comes from Omega-3 fatty acids which are anti-inflammatory in nature. A. Cod liver oil B. Salmon C. Walnuts D. Chia seeds Note: Histamines work with prostaglandins and are created by Basophils, a leukocyte or white blood cell, and histamines increase the permeability of blood cells to allow the white blood cells to move to the infected or injured tissues. 6. Good blood sugar regulation is important for optimal immune health A. Stress responses by the adrenal glands depress the immune system. The body has to decide if it's going to lower blood sugar or fight infection B. Blood sugar levels that are consistently high reduce white blood cell activity because high blood sugar levels cause high cortisol levels and cortisol is the hormone that regulates white blood cells 1. High cortisol levels decrease lymphocytes and other immune cells 2. Low cortisol causes an overactive immune system-white blood cells are in excess and this causes inflammation. 3. blood sugar levels that are consistently high deplete the body of nutrients needed for a healthy immune system 1. Vitamin C-certain cells of the immune like phagocytes and T-cells system need vitamin C to do their job 2. Vitamin D-helps the body produce over 200 antimicrobial peptides (2 or more amino acids) which help fight infections 3. Vitamin E-antioxidant that helps fight infection 4. Zinc-helps regulate the immune response 5. Beta-carotene-precursor to vitamin A which is needed for healthy mucous membranes 6. Calcium-helps support white blood cell activity 7. Iodine-a natural anti-bacterial and anti-viral agent 7. Proper hydration is needed for a healthy immune system A. Water is needed to keep the passageways of the lungs moist for easier breathing B. Proper hydration supports good lymphatic flow which allows the immune system cells to travel easier throughout the body C. If you are dehydrated, it can increase the histamine response which plays a role in allergies and asthma 8. Ways we rid the body of invaders A. Coughing, B. Sneezing C. Defecating D. Vomiting E. Tears F. Saliva 7. Immune Supporting Nutrients A. Vitamins A, C, D, and E B. Zinc C. Selenium D. Essential Fatty Acids 1. Linoleic Acid (LA) 2. Alph-Linolenic Acid (ALA) E. Aloe Vera-a gelatinous substance obtained from Aloe plants F. Garlic-an herb closely related to the onion family G. Licorice-from a plant in the pea family obtained from it's roots H. Echinasea- derived from a North American coneflower in the Daisy family that has antibiotic and wound healing properties Nutritional Pearl for Episode 17: It's important that we have good digestive function, proper hydration, and optimal blood sugar regulation so that our immune system can function at its best. YOUR NEW KETO DIET ALLY NOTICE OF DISCLOSURE: Paid sponsorship BECOME A NUTRITIONAL THERAPY PRACTITIONER NOTICE OF DISCLOSURE: Paid sponsorship LINKS MENTIONED IN EPISODE 17 – SUPPORT OUR SPONSOR: Complete nutriton for nutritional ketosis () – SUPPORT OUR SPONSOR: –
Congenital heart disease isn't just diagnosed in the antenatal period and during post-natal examination. Nick Pigott takes us through the three main presentations of congenital heart disease (shock, cyanosis and heart failure) and reassures us that treating these patients is simpler than we think, urging us to consider cardiac disease in the sick newborn. He covers duct-dependent lesions, structural obstructive lesions, immediate resuscitation, the usefulness of physical examination, a deeper dive into hyperplastic left heart syndrome, the known cardiac patients (and what to do with them) and the paediatric cardiology wonder-drug: Prostaglandin infusion.
Background: Portal pressure (PP) results from the interplay ofvasoconstrictors and vasodilators. Recently, we have shown that Kupffercell (KC) activation increases PP. Aims: The role of the vasodilatingcompounds nitric oxide (NO) and carbon monoxide (CO) was studied. Thehypothesis of the present study was that these vasodilators counteractthe PP increase following KC activation. Methods: Livers of ratsweighing 180-200 g were isolated and perfused. KCs were activated byzymosan A (cell wall particles from yeast; 150 mu g/ml). The effects ofNO and guanylate cyclase (GC) were evaluated by the NO synthaseinhibitor N-G-nitro-L-arginine methylester (L-NAME; 0.3 m M, and the GCinhibitor 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one(NS-2028, 1.0 mu M); the effects of the heme oxygenase (HO) derivedcompound CO were evaluated by direct administration of CO or inhibitionof HO by zinc protoporphyrin IX (ZnPP IX, 1.0 mu M). Results: Inisolated perfused rat livers, administration of L-NAME or NS-2028further raised PP increase following KC activation. This effect could bereduced by the cGMP analogue 8-Br-cGMP. Inhibition of HO caused markedamplification of PP increase in zymosan-treated organs. CO preventedthis PP increase cGMP independently. Interestingly, KC activation andsimultaneous inhibition of HO augmented the production of prostaglandinsD-2 and F-2 alpha and of thromboxane A(2). Accordingly, indomethacinblunted the increase of PP in zymosan/ZnPP-treated livers. Conclusions:NO restricts the initial PP increase after KC activation by GC-mediatedcGMP. CO from heme degradation limits the increase of PP after KCactivation eicosanoid dependently, but cGMP independently.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19
Thu, 12 Jan 2012 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/14225/ https://edoc.ub.uni-muenchen.de/14225/1/Schell_Christoph.pdf Schell, Christoph ddc:610, d
What causes pain and how do we stop it? This unit looks at how the human body responds to the release of certain chemicals and as a result feels pain. Pain can be reduced by inhibiting the formation of such chemicals and you will learn how the molecular structure of aspirin has been formulated to help in this process. This study unit is just one of many that can be found on LearningSpace, part of OpenLearn, a collection of open educational resources from The Open University. Published in ePub 2.0.1 format, some feature such as audio, video and linked PDF are not supported by all ePub readers.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 11/19
Im Mittelpunkt der Arbeit stehen die Auswirkungen des Prostanoids Prostaglandin E2 (PGE2) auf die Fähigkeit von Monozyten-abgeleiteten dendritischen Zellen (MoDC) zur Antigenpräsentation auf MHC-I- und MHC II Molekülen. Die Kreuzpräsentation von exogenem Antigen auf MHC I Molekülen ist eine entscheidende Fähigkeit der dendritischen Zellen (DC), die es ihnen ermöglicht zytotoxische T-Zellen zu aktivieren. PGE2 wird in Aktivierungsprotokollen als „Goldstandard“ in Kombination mit Zytokinen, wie TNF-α, IL-1β und IL 6, als Reifestimulus für DC in klinischen DC-basierten Tumorvakzinierungsstudien verwendet. Bisher wurde über den Effekt von PGE2 auf die Antigenpräsentation von Tumorantigen in Proteinform nicht berichtet. In dieser Arbeit wurde die Auswirkung von PGE2 und spezifischen EP Rezeptoragonisten auf verschiedene Funktionen von MoDC, die für die Antigenpräsentation auf MHC-I- und MHC-II-Molekülen relevant sind, untersucht. Zuerst wurde die Auswirkung von PGE2 und den EP Rezeptoragonisten auf die Ausreifung der MoDC untersucht. Hierbei wurde ersichtlich, dass MoDC nach Inkubation mit PGE2, vermittelt über EP2/4 Rezeptoren, die Aktivierungsmarker HLA A, HLA-B und HLA-C3, HLA-DR, CD83 und CD86 hochregulieren. Als nächstes wurde der Einfluss von PGE2 auf die Antigenaufnahmefähigkeit der MoDC untersucht. Hierbei wurde die Phagozytosefähigkeit anhand von Zelllysat und apoptotischen Tumorzellen und die Makropinozytosefähigkeit anhand von Dextran Partikeln analysiert. Es konnte gezeigt werden, dass weder PGE2 noch spezifische EP Rezeptoragonisten die Antigenaufnahme signifikant beeinflussten. Durch Präsentation von Antigen auf MHC-II-Molekülen sind DC in der Lage, tumorspezifische CD4+ T-Zellen zu aktivieren. Die MHC-II Präsentationsfähigkeit der MoDC unter dem Einfluss von PGE2 wurde mit NY-ESO-1157-170 Peptid, NY-ESO-1 Protein sowie mit NY ESO 1-transfiziertem CHO Zelllysat als Antigenquellen untersucht. PGE2 wurde zu den MoDC entweder 24 h vor (Präinkubation) oder zur gleichen Zeit wie das Antigen (Simultaninkubation) hinzugefügt. Die Versuche ergaben, dass die MHC-II-Antigenpräsentation der MoDC durch PGE2 nicht signifikant beeinflusst wird. Die Auswirkung von PGE2 auf die Kreuzpräsentationsfähigkeit der MoDC wurde mit einer Formulierung aus NY-ESO-1 Protein und dem ISCOMATRIX® adjuvant (NY ESO-1/IMX) und einem Immunkomplex bestehend aus NY-ESO-1 Protein und dem Antikörper anti NY ESO-1 mAk (Klon ES121; NY-ESO-1/IC) untersucht. Hierbei konnte gezeigt werden, dass sowohl die Kreuzpräsentation von NY-ESO-1/IMX als auch von NY ESO 1/IC durch PGE2 dosisabhängig signifikant gehemmt wurde. Dieser Effekt wird, ähnlich wie die Zell-Reifung, über die EP2/4-Rezeptoren vermittelt. Zusammenfassend erlauben die Ergebnisse den Schluss, dass PGE2 über einen EP2/4-Rezeptor-vermittelten Mechanismus die Kreuzpräsentationsfähigkeit der MoDC inhibiert, ohne jedoch die Antigenaufnahme oder die MHC-II Präsentation signifikant zu beeinflussen. Eine klinische Relevanz der Ergebnisse besteht bei der Verwendung von DC für therapeutische Tumorvakzinierungen zur Induktion einer gegen Malignome gerichteten Immunantwort. Die Benutzung von PGE2 als Reifestimulus für MoDC, die mit Protein-Antigenen gepulst werden, birgt das Risiko, die Induktion von tumorantigenspezifischen CD8+ T-Zellen negativ zu beeinflussen.
Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their effects on EPC production, trafficking and function. Methods and Results: We found that EPC are a rich source for prostaglandin E 2 (PGE 2), stimulating their number and function in an auto- and paracrine manner. In vivo blockade of PGE 2 production by selective cyclooxygenase-2 inhibition virtually abrogated ischemia-induced EPC mobilization demonstrating its crucial role in EPC homeostasis following tissue ischemia. Conversely, ex vivo treatment of isolated EPC with the clinically approved PGE 1 analogue alprostadil enhanced EPC number and function. These effects were mediated by increased expression of the chemokine receptor CXCR4 and were dependent on nitric oxide synthase activity. Most importantly, ex vivo PGE 1 pretreatment of isolated EPC significantly enhanced their neovascularization capacity in a murine model of hind limb ischemia as assessed by laser Doppler analysis, exercise stress test and immunohistochemistry. Conclusions: The conserved role for PGE in the regulation of EPC homeostasis suggests that ex vivo modulation of the prostaglandin pathway in isolated progenitor cells may represent a novel and safe strategy to facilitate cell-based therapies. Copyright (C) 2009 S. Karger AG, Basel
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 09/19
Basierend auf den Ergebnissen klinischer Studien müssen bakterielle Infektionen als Trigger akuter Ösophagusvarizenblutungen bei Patienten mit Leberzirrhose angenommen werden. Hierfür werden Permeabilitätsstörungen der Darmwand als Folge der portalen Hypertonie verantwortlich gemacht, die eine Einschwemmung pathogener Darmkeime in die portale Zirkulation begünstigen. Kupffer'sche Sternzellen (KS), die residenten Makrophagen der Leber, kommen nicht nur als größte sondern auch als erste Makrophagenpopulation des menschlichen Körpers mit pathogenen Darmbakterien in Kontakt. Durch bakterielle Bestandteile wie Endotoxine oder die in der Zellwand von Bakterien und Pilzen verankerten β-Glucane, werden KS aktiviert und produzieren in der Folge verschiedene Vasokonstriktoren, die den portalen Druck massiv erhöhen. Die von aktivierten KS gebildeten Vasokonstriktoren sind deshalb als potenzielle Mediatoren einer Infekt- getriggerten Varizenblutung anzusehen. Von großem klinischen Interesse ist deshalb die Identifizierung der verantwortlichen Vasokonstriktoren als Basis für die Entwicklung pharmakologischer Strategien zur Prävention Infekt- getriggerter Varizenblutungen. Bislang konnte die Beteiligung des Cyclooxygenase- Weges und insbesondere die Bildung von Thromboxan A2 (TXA2) an der portalen Druckerhöhung durch aktivierte KS nachgewiesen werden. Allerdings konnte im Tierexperiment durch den Einsatz von Cyclooxygenase- Inhibitoren und TXA2 -Antagonisten der portale Druckanstieg nach KS Aktivierung nur um 50% reduziert werden, weshalb die Beteiligung weiterer Vasokonstriktoren angenommen werden muss. Die Identifizierung der bislang unbekannten Vasokonstriktoren als wesentliches Ziel der vorliegenden Arbeit erscheint nicht zuletzt auch deshalb von besonderem klinischen Interesse, da sich eine pharmakologische Hemmung der bislang identifizierten Cyclooxygenase- bzw. TXA2- abhängigen Wege der Vasokonstriktion bei Patienten mit Leberzirrhose wegen der Gefahr schwerwiegender Nebenwirkungen verbietet. In der vorliegenden Arbeit sollte deshalb die Rolle vasokonstriktorischer Cysteinyl-Leukotriene (Cys-LT) bei der portalen Druckerhöhung durch aktivierte KS untersucht werden. Die Experimente wurden am Modell der isoliert perfundierten Rattenleber durchgeführt. Zusammenfassend führen die Ergebnisse zu einem neuen Konzept der portalen Hypertension durch β-Glucane unter Beteiligung aktivierter KS, TXA2 und Cys-LT. Ferner zeigen diese Ergebnisse erstmals eine bislang nicht beschriebene Vernetzung von Prostaglandin- und Cys-LT- Signalwegen unter der Kontrolle von TXA2- und Cys-LT1-Rezeptoren. Für die portale Druckerhöhung nach KS-Aktivierung muss ein durch TXA2 mediierter Mechanismus der Cys-LT –Bildung mit nachfolgender CysLT1–Rezeptorstimulation angenommen werden. 5-Lipoxygenase- Inhibitoren wie MK 886, die die Synthese von Prostanoiden nicht beeinflussen, sind dabei als besonders aussichtsreiche Kandidaten zur pharmakologischen Prävention der Infekt- getriggerten portalen Hypertension zu erachten.
Guest: William G. Hodge, MD, MPH, PhD Professor of Ophthalmology and EpidemiologyUniversity of Ottawa Eye InstituteOttawa, ON
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19
Tue, 19 Jun 2007 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/7035/ https://edoc.ub.uni-muenchen.de/7035/1/Schaefer_Meike.pdf Schaefer, Meike
Guest: Smajo S. Osmanovic, MD, PhDClinical Assistant ProfressorDepartment of Ophthalmology and Visual SciencesIllinois Eye & Ear InfirmaryUniversity of Illinois at Chicago
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 04/19
Pathophysiologisch ist die Herzinsuffizienz definiert als Unfähigkeit des Herzens, Blut und somit Sauerstoff in einem Maße, das den Bedürfnissen gerecht wird, zu den Organen zu transportieren (WHO 1995)23. Die in fortgeschrittenen Stadium an einer Herzinsuffizienz Erkrankten haben eine schlechte Prognose. Anders als bei Patienten mit Linksherzinsuffizienz kann die Infusion von Prostaglandin I2 Analoga bei Patienten mit pulmonaler Hypertonie und Rechtsherzinsuffizienz des Schweregrades NYHA III – IV die Hämodynamik und das Überleben dieser Patienten verbessern7. Als dafür verantwortlicher Wirkmechanismus wurden bisher ausschliesslich die vasodilatierenden Eigenschaften von Prostanoiden vermutet. Zwar konnte eine positiv inotrope Wirkung von Prostaglandin I2 bereits vor mehreren Jahren erstmals in vitro gezeigt werden4,25,71,88, stichhaltige in vivo Studien hierzu fehlten allerdings bislang. Das Ziel unserer Studie war es aber, die Wirkung der Prostaglandin I2 auf die Myokardkontraktilität in vivo nachzuweisen. Da eine kontraktilitätssteigernde Wirkung im Herzen meist über einen cAMP Anstieg ausgelöst wird101, sollte mit vorliegender Forschungsarbeit die Wirkung der Prostaglandin I2 Analoga sowohl auf myokardiales cAMP als auch die linksventrikuläre Kontraktilität untersucht werden.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 03/19
Epidemiologische Daten und Tiermodelle geben Hinweise auf eine verschlechterte Immunabwehr bei Karzinomen des Kopf- und Halsbereiches, wobei die genauen Wirkmechanismen bisher nicht aufgeschlüsselt werden konnten. In Untersuchungen konnte gezeigt werden, dass Karzinome im Kopf- und Halsbereich mit erhöhten Konzentrationen an Prostaglandinen im Serum einhergehen, ein anderer Autor wies eine verminderte Expression des Chemokinrezeptors CCR5 auf Monozyten nach Behandlung mit Prostaglandin nach. In der vorliegenden Arbeit konnte erstmalig aufgezeigt werden, dass es im Rahmen einer Karzinomerkrankung im Hals- und Kopfbereich zu strukturellen und funktionellen Defiziten der Monozytenfunktion kommt. Hierbei finden sich erniedrigte Expressionsraten an CCR5, CCR2 und des Adhäsionsmoleküls CD11b des β-Integrins Mac-1 sowie eine verminderte Adhäsionsfähigkeit der Monozyten an das interzelluläre Adhäsionsmolekül ICAM-1. Weiterhin konnte nachgewiesen werden, dass nach Inkubation der Monozyten in Serum gesunder Spender die verminderte Immunfunktion wieder verbessert wird. Parallel dazu zeigte sich, dass die oben beschriebenen Immundefekte auf Monozyten gesunder Spender durch Inkubation in Serum von Tumorpatienten künstlich herbeigeführt werden können. Dies legt den Schluss nahe, dass im Rahmen einer Karzinomerkrankung Metaboliten im Serum gelöst sind, die eine immunologische Tumorabwehr erschweren. Diese Erkenntnisse sind ein weiterer Schritt zum Verständnis der Tumorimmunologie und könnten dazu hilfreich sein, immunologische Therapieverfahren voranzubringen.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 03/19
Das Krankheitsbild der chronisch rezidivierenden vulvovaginalen Candidose stellt sowohl diagnostisch als auch therapeutisch nach wie vor eine Herausforderung für den behandelnden Arzt dar. Wir untersuchten 104 Patientinnen, die klinisch Symptome wie Erythem, Pruritus, Brennen und weißlichen Fluor aufwiesen und mbei mindestens vier Episoden pro Jahr die Diagnose einer CRVVC gestellt wurde. Als Kontrollgruppe dienten 44 asymptomatische Patientinnen ohne anamnestische Pilzinfektion. Zum Nachweis von Candida und der Spezifizierung des Pilzes aus gewonnenem Vaginalsekret verwendeten wir sowohl die Methode der kulturellen Anzüchtung als die der PCR. Des Weiteren bestimmten wir mittels Elisa die Zytokine Interleukin-4, Interleukin-5, Interleukin-13 wie auch ProstaglandinE2, candidaspezifisches IgE und Gesamt-IgE aus dem Vaginalsekret. In der Gruppe der symptomatischen Patientinnen konnte bei nur 42,3% eine Pilzinfektion mittels PCR nachgewiesen werden, kulturell sogar nur bei 29,8% der Frauen, so dass bei 57,7% keine Pilzinfektion zum Zeitpunkt der Probenentnahme nachzuweisen war. Innerhalb der asymptomatischen und klinisch befundfreien Kontrollgruppe wurden 3 Patientinnen mit Hilfe der PCR positiv auf Candida getestet. Die Auswertung der Messergebnisse von IL-5, IL-13 und Gesamt-IgE zeigte im Vergleich der symptomatischen Patientinnen mit der Kontrollgruppe keine Zusammenhänge. Signifikante Unterschiede hingegen bestanden in der Konzentration von IL-4 (p
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 03/19
Thu, 8 Jul 2004 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/2419/ https://edoc.ub.uni-muenchen.de/2419/1/Eftimescu_Adriana.pdf Eftimescu, Adriana ddc:610, ddc:600, M
Sat, 1 Jan 1994 12:00:00 +0100 https://epub.ub.uni-muenchen.de/10326/1/10326.pdf Jonas, Udo; Stief, Christian Georg; Djamilian, Mohamad H.; Kuczyk, M.; Thon, Walter F.; Becker, Armin J.; Truss, Michael C.
Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9821/1/9821.pdf Jonas, Udo; Kuczyk, M.; Stief, Christian Georg; Djamilian, Mohamad H.
Sun, 1 Jan 1989 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9835/1/9835.pdf Tanagho, Emil A.; Lue, Tom F.; Stackl, W.; Stief, Christian Georg; Aboseif, Sherif R.; Bénard, Francois; Bosch, Ruud J. L. H.
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