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A yawn spreads quickly. You see someone yawn, you think about yawning, or you even read the word “yawn”—and suddenly you're doing it too. This episode begins by looking at why yawning is so contagious, what theories actually hold up, and what science still can't explain. https://www.livescience.com/human-behavior/why-is-yawning-contagious A Christmas tree seems like such a natural part of the holiday season, but the tradition behind it is rich, surprising, and deeply woven into American history. Why an evergreen? Where did the practice originate? How do they select the giant tree for Rockefeller Center every year? Here to explain the story and the symbolism behind the Christmas tree is Trent Preszler, professor of Applied Economics and Management at Cornell University and author of the book Evergreen: The Trees That Shaped America. (https://amzn.to/43NUVSj). Dining out today is nothing like it was just a few years ago. Prices are higher, tipping culture has shifted, customer expectations are changing, and restaurants face tighter margins than ever. Adam Reiner joins me with a behind-the-scenes look at what's really happening in the industry and offers practical advice for getting the best experience when you eat out. Adam is a food writer whose work has appeared in Bon Appétit, Food & Wine, and New York Magazine, and he's author of The New Rules of Dining Out (https://amzn.to/3Xhg0kf). You would think eating food should satisfy you—yet some foods do the opposite. Highly processed foods digest so quickly and trigger such different responses in your body that they can actually leave you hungrier. I explain what the science shows and why these foods can lead to overeating. https://www.nih.gov/news-events/nih-research-matters/eating-highly-processed-foods-linked-weight-gain PLEASE SUPPORT OUR SPONSORS! AURA FRAMES: Visit https://AuraFrames.com and get $45 off Aura's best selling Carver Mat frames by using promo code SOMETHING at checkout. INDEED: Get a $75 sponsored job credit to get your jobs more visibility at https://Indeed.com/SOMETHING right now! DAVID GREENE IS OBSESSED: We love the "David Greene Is Obsessed" podcast! Listen at https://link.mgln.ai/SYSK or wherever you get your podcasts. QUINCE: Give and get timeless holiday staples that last this season with Quince. Go to https://Quince.com/sysk for free shipping on your order and 365 day returns! DELL: It's time for Cyber Monday at Dell Technologies. Save big on PCs like the Dell 16 Plus featuring Intel® Core™ Ultra processors. Shop now at: https://Dell.com/deals AG1: Head to https://DrinkAG1.com/SYSK to get a FREE Welcome Kit with an AG1 Flavor Sampler and a bottle of Vitamin D3 plus K2, when you first subscribe! NOTION: Notion brings all your notes, docs, and projects into one connected space that just works . It's seamless, flexible, powerful, and actually fun to use! Try Notion, now with Notion Agent, at: https://notion.com/something PLANET VISIONARIES: In partnership with Rolex's Perpetual Planet Initiative, this… is Planet Visionaries. Listen or watch on Apple, Spotify, YouTube, or wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices
What if the biggest threat to your brand's profitability isn't the next tariff or supply chain disruption, but an outdated playbook that forces you to choose between raising prices on loyal customers or sacrificing your margins?Agility requires more than just reacting quickly to market changes; it requires the intelligence to anticipate them and automate the optimal response. Today, we're going to talk about how leading retail brands are navigating complex economic pressures like tariffs and inflation—not by resorting to the old tactics of deep discounts or across-the-board price hikes, but by deploying AI to create a more resilient and intelligent operation. We'll explore how AI is helping brands maintain pricing stability, turn insights from major shopping events into real-time strategy, and fundamentally shift teams from staring at dashboards to taking automated, margin-protecting actions. To help me discuss this topic, I'd like to welcome, Sai Koppala, CMO at CommerceIQ. About Sai Koppala Sai brings over 20 years of marketing and strategy experience. Before CommerceIQ, he was Chief Marketing & Strategy Officer at SheerID and held leadership roles at Apigee (acquired by Google) and SAP. He holds an MBA from the Kellogg School of Management and a Master's in Electrical Engineering from Arizona State University. Sai Koppala on LinkedIn: https://www.linkedin.com/in/koppala/ Resources CommerceIQ: https://www.commerceiq.com The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://www.teksystems.com/versionnextnow Catch the future of e-commerce at eTail Palm Springs, Feb 23-26 in Palm Springs, CA. Go here for more details: https://etailwest.wbresearch.com/ Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstromDon't miss a thing: get the latest episodes, sign up for our newsletter and more: https://www.theagilebrand.showCheck out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company
BONUS: Impact Engineering—Finding Agile's Lost North Star With Tom Gilb and Simon Holzapfel The Clarity Problem: Why Organizations Start with "Fuzzy B*S*!" "Everybody seems to start from a position of fuzzy b*s*. Nice-sounding words. Management does it, professors do it, politicians do it. And they don't even feel very guilty about it." Tom Gilb doesn't mince words when describing how most organizations define their objectives. The fundamental problem isn't a lack of ambition—it's a lack of clarity. When leaders are asked about their critical values like "extremely high security" or "employee happiness," they typically respond with circular definitions that provide no actionable direction. Tom's approach starts by exposing this gap and then demonstrating that any value—no matter how "soft" or intangible it seems—can be quantified. Using AI tools, he's shown clients over 1,400 different ways to measure human happiness alone. Why Agile Lost Its North Star "Agile's lost its North Star because the economic problems it was trying to solve within the organization are now mismatched with the digital world." Simon Holzapfel offers a structural analysis: Agile developed primarily to allay the concerns of pre-digital capital—investors who needed reassurance that their money wouldn't disappear into failed projects. But today's digital economy operates differently. Capital now moves like a service (SaaS model), and innovation is fundamentally stochastic—you can't predict when breakthroughs will happen. Organizations using flow-focused tools when the real problem is value creation are applying yesterday's solutions to today's challenges. The First Step: Quantify Your Critical Values "If you ask AI to quantify employee happiness a hundred different ways, it will do it in one minute for free. So you can no longer be in denial." The path forward starts with brutal honesty about what your organization actually cares about. Tom's approach involves: Identifying the top 10 critical stakeholder values Defining clear scales of measure for each Establishing where you are now (status) Setting where you need to be to survive (tolerable level) Defining what success looks like (target/goal level) This isn't about adding bureaucracy—it's about creating shared clarity that enables everyone to row in the same direction. About Tom Gilb and Simon Holzapfel Tom Gilb, born in the US, lived in London, and then moved to Norway in 1958. An independent teacher, consultant, and writer, he has worked in software engineering, corporate top management, and large-scale systems engineering. As the saying goes, Tom was writing about Agile before Agile was named. In 1976, Tom introduced the term "evolutionary" in his book Software Metrics, advocating for development in small, measurable steps. Today, we talk about Evo, the name Tom uses to describe his approach. Tom has worked with Dr. Deming and holds a certificate personally signed by him. You can listen to Tom Gilb's previous episodes here. You can link with Tom Gilb on LinkedIn Simon Holzapfel is an educator, coach, and learning innovator who helps teams work with greater clarity, speed, and purpose. He specializes in separating strategy from tactics, enabling short-cycle decision-making and higher-value workflows. Simon has spent his career coaching individuals and teams to achieve performance with deeper meaning and joy. Simon is also the author of the Equonomist newsletter on Substack. And you can listen to Simon's previous episodes on the podcast here. You can link with Simon Holzapfel on LinkedIn.
It is that time of year – you have a list of things to do that is nearly a mile long. Your mind is scrambled, and you are trying to remember what you need to do for the practice and team to wrap up 2025 nicely. Dr. Kuba and Bethany are here to help! Together, they put together a list of their top year-end tips and reminders. Some of the items are easy to forget, like evaluating your fee schedule, while others are more challenging like evaluating your A/R trends. Nonetheless, this episode will help you maximize the last few weeks of this year to ensure that everything is checked off your list (and hopefully you don't have to check it twice!). If you're a subscriber, don't miss the BLACK FRIDAY SALE on the Hub. For the next 3 days, all Hub resources are 50% off!!
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Spine specialist, Dr. Nate McKee shares a success story about a patient with tandem stenosis. Dr. Nate McKee grew up in Fort Wayne, IN. He was first introduced to the great state of Michigan, when he attended Albion College. At Albion College, Dr. Nate received his Bachelor's in Exercise Sciences. He then went onto National University of Health Sciences in Lombard, IL where he received his Doctorate in Chiropractic. While at National, he was actively involved in the Student American Chiropractic Association, and was President. During that involvement he lobbied in Washington, D.C. for rights and access for chiropractic patients such as: Veteran's access, underserved areas, Tricare, etc. Dr. Nate was also a school tutor for Head & Neck and Thoracic Evaluation, Management, and Manipulation courses for two years. During his clinical experience, Dr. Nate did a 2 month rotation at the Roudebush VA Medical Center in Indianapolis, IN. Dr. Nate has furthered his education and received a certification in Cox Decompression and Manipulation Technic. His education in Cox Technic allows him to treat various conditions of the neck, back, and knees such as but not limited to: disc herniations, spinal stenosis, post surgical pain, back pain related to pregnancy, headaches, and meniscal pain of the knee. Dr. Nate is also a Certified Chiropractic Sports Physician® (CCSP®), which has equipped him with the training to treat and prevent sports injuries and to properly work with athletes. References: Chiropractic Management using Cox Technic Flexion Distraction for a Patient With Tandem Spinal Stenosis Resources: Connect with Dr. McKee Dr. Mckee's office 810-223-2439 Connect on Facebook Instagram @McKeeChiro Find a Back Doctor The Cox 8 Table by Haven Medical
Review for Final Exam Business Finance, FIL 240-002, Autumn 2025, Lecture 29 Type: mp3 audio file ©2025
Review for Final Exam Business Finance, FIL 240-001, Autumn 2025, Lecture 29 Type: mp3 audio file ©2025
Dr. Shad Morris is a Professor of Management at the Marriott School of Business and the Director of the Whitmore Global Business Center. In this discussion, Dr. Morris shares inspiring stories about international experiences in education and business that will change the way you think about stepping out of your comfort zone and taking global opportunities.
In this inspiring episode of our Alumni Spotlight series, we sit down with Vanessa Ramirez, a proud graduate of the Law Magnet Class of 2013.With over 12 years of experience in project management, Vanessa has led major initiatives for global industry giants like Verizon, PDI Technologies, and Goldman Sachs. Holding dual master's degrees in Business Administration (MBA) and Public Administration (MPA), she is known for her leadership, innovation, and dedication to helping teams succeed.In this conversation, we discuss:From Townview to Tech: How her Law Magnet foundation shaped her professional journey.Corporate Leadership: Lessons learned managing initiatives for companies like Goldman Sachs.Finding Purpose: Advice on career growth, perseverance, and making an impact through technology.Join us as we celebrate 50 years of the School of Business and Management and 30 years of Townview Magnet Center excellence.Keywords: Project Management, Women in STEM, Townview, Law Magnet, Career Advice, MBA, MPA, Goldman Sachs.
In this inspiring episode of our Alumni Spotlight series, we sit down with Vanessa Ramirez, a proud graduate of the Law Magnet Class of 2013.With over 12 years of experience in project management, Vanessa has led major initiatives for global industry giants like Verizon, PDI Technologies, and Goldman Sachs. Holding dual master's degrees in Business Administration (MBA) and Public Administration (MPA), she is known for her leadership, innovation, and dedication to helping teams succeed.In this conversation, we discuss:From Townview to Tech: How her Law Magnet foundation shaped her professional journey.Corporate Leadership: Lessons learned managing initiatives for companies like Goldman Sachs.Finding Purpose: Advice on career growth, perseverance, and making an impact through technology.Join us as we celebrate 50 years of the School of Business and Management and 30 years of Townview Magnet Center excellence.Keywords: Project Management, Women in STEM, Townview, Law Magnet, Career Advice, MBA, MPA, Goldman Sachs.
How does a country sliding toward autocracy affect its economy? Political scientist and author Barbara F Walter offers data-driven insights about why the murky middle ground between democracy and autocracy is bad for business. She talked with host Jeff Berman live on stage at the 2025 Masters of Scale Summit. Walter's book: https://bookshop.org/p/books/how-civil-wars-start-and-how-to-stop-them-barbara-f-walter/35f702a0af16f18aWalter's Substack: https://barbarafwalter.substack.com/Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/newsletter/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Play audio-only episode | Play video episode | Play on YouTube | Play on Spotify Click above to play either the audio-only episode or video episode in a new window. Episode Summary Subtle problems often start long before a project shows obvious signs of distress. Leaders feel the pressure to deliver momentum, teams shift toward activity over outcomes, and stakeholders slowly fade as competing priorities pull them away. In this conversation, Matthew Oleniuk brings his experience from overseeing large public sector projects and highlights seven early indicators that signal when a project is heading toward trouble. He explains why these issues are easy to ignore, how they quietly compound over time, and why strong leadership vigilance matters more than any dashboard color. He also describes how patterns like output beating outcome, performance theater, and risk box ticking show up in real projects and why they are so harmful when left unchallenged.
Tune into the next episode of Talk Law Radio Show and Podcast, where property management expert, Lorena N. Jáuregui de Birdy, dives deep into the must-know strategies for navigating residential rentals—like dodging common pitfalls, mastering tenant laws, and maximizing your investment returns. ⚖️
After another plague of delays, we finally complete our miniseries on aging with the darkest and most brutal depiction of it we've seen. Once again, we return to Natasha, Pierre, & The Great Comet of 1812 by Dave Malloy with "The Private and Intimate Life of the House." This isn't a fun one, so listen with care. We will be back on January 15, 2026 with something unlike we've ever done -- stay tuned! All clips are from 2017's Natasha, Pierre, and The Great Comet of 1812: Original Broadway Cast Recording featuring Gelsey Bell and Nicholas Belton and are protected by the Fair Use guidelines of Section 107 of the Copyright Act for criticism and commentary. All rights reserved to the copyright owners. N.B. This episode was also plagued by some audio issues. It is entirely listenable, but it's a bit quiet at times. Management regrets the inconvenience. Listen to the SMSTS playlist on Spotify! Follow SMSTS on Instagram: @somuchstufftosing Email the show: somuchstufftosing@gmail.co
Prosthetic joint infections (PJI) remain among the most devastating complications in orthopedic surgery, with increasing incidence paralleling the growth in arthroplasty procedures worldwide. While treatment protocols are well-established, evidence supporting current approaches is lacking, and outcomes remain suboptimal, highlighting the need for improved therapeutic strategies. AAC recently published a minireview of randomized controlled trials and emerging evidence for the management for these difficult to treat infection. Today, we discuss with one of the authors of the manuscript and an ID doctor specialized in PJI infections the findings of such paper. Topics discussed: Challenges of treating prosthetic joint infections. Major clinical trial data supporting different approaches for treatment and prevention of PJI Guidance for the approach to these complicated infections. Guests: David Paterson MBBS, Ph.D., Professor, Saw Swee Hock School of Public Health (Joint) Yong Loo Lin School of Public Health (Joint), Director, ADVANCE-ID, National University of Singapore, Singapore. Ana Victoria Salas-Vargas, M.D. Assistant Professor of Clinical Medicine, Houston Methodist Academic Institute and Weill Cornell Medical College. This episode is brought to you by the Antimicrobial Agents and Chemotherapy Journal. Visit asm.org/aac to browse issues and/or submit a manuscript. If you plan to publish in AAC, ASM Members get up to 50% off publishing fees. Visit asm.org/joinasm to sign up.
In this episode, the CardioNerds (Dr. Naima Maqsood, Dr. Akiva Rosenzveig, and Dr. Colin Blumenthal) are joined by renowned educator in electrophysiology, Dr. Joshua Cooper, to discuss everything atrial flutter; from anatomy and pathophysiology to diagnosis and management. Dr. Cooper's expert teaching comes through as Dr. Cooper vividly describes atrial anatomy to provide the foundational understanding to be able to understand why management of atrial flutter is unique from atrial fibrillation despite their every intertwined relationship. A foundational episode for learners to understand atrial flutter as well as numerous concepts in electrophysiology. Audio editing for this episode was performed by CardioNerds intern Dr. Bhavya Shah. CardioNerds Atrial Fibrillation PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls "The biggest mistake is failure to diagnose”. Atrial flutter, especially with 2:1 conduction, is commonly missed in both inpatient and outpatient settings so look carefully at that 12-lead EKG so you can mitigate the stroke and tachycardia induced cardiomyopathy risk Decremental conduction of the AV node makes it more challenging to rate control atrial flutter than atrial fibrillation Catheter Ablation is the first line treatment for atrial flutter and is highly successful, but cardioversion can be utilized as well prior to pursuing ablation in some cases. Class I AADs like propafenone and flecainide may stability the atrial flutter circuit by slowing conduction and thus may worsen the arrhythmia. Therefore, the preferred anti-arrhythmic medication in atrial flutter are class III agents. Atrial flutter can be triggered by firing from the left side of the heart, so in patients with both atrial fibrillation and flutter, ablating atrial fibrillation makes atrial flutter less likely to recur. BONUS PEARL: Dr. Cooper's youtube video on atrial flutter is a MUST SEE! Notes Notes: Notes drafted by Dr. Akiva Rosenzveig What are the distinguishing features of atrial fibrillation and flutter? Atrial flutter is an organized rhythm characterized by a wavefront that continuously travels around the same circuit leading to reproducible P-waves on surface EKG as well as a very mathematical and predictable relationship between atrial and ventricular activity Atrial fibrillation is an ever changing, chaotic rhythm that consists of small local circuits that interplay off each other. Consequently, no two beats are the same and the relationship between the atrial activity and ventricular activity is unpredictable leading to an irregularly irregular rhythm What are common atrial flutter circuits? Cavo-tricuspid isthmus (CTI)-dependent atrial flutter is the most common type of flutter. It is characterized by a circuit that circumnavigates the tricuspid valve. Typical atrial flutter is characterized by the circuit running in a counterclockwise pattern up the septum, from medial to lateral across the right atrial roof, down the lateral wall, and back towards the septum across the floor of the right atrium between the IVC and the inferior margin of the tricuspid valve i.e. the cavo-tricuspid isthmus. Surface EKG will show a gradual downslope in leads II, III, and AvF and a rapid rise at end of each flutter wave. Atypical CTI-dependent flutter follows the same route but in the opposite direction (clockwise). Therefore, we will see positive flutter waves in the inferior leads Mitral annular flutter is more commonly seen in atrial fibrillation patients who've been treated with ablation leading to scarring in the left atrium. Roof-dependent flutter is characterized by a circuit that travels around left atrium circumnavigating a lesion (often from prior ablation), traveling through the left atrial roof, down the posterior wall, and around the pulmonary veins Surgical/scar/incisional flutter is seen in people with a history of prior cardiac surgery and have iatrogenic scars in right atrium due to cannulation sites or incisions How does atrial flutter pharmacologic management differ from other atrial arrhythmias? The atrioventricular (AV) node is unique in that the faster it is stimulated, the longer the refractory period and the slower it conducts. This characteristic is called decremental conduction. In atrial fibrillation, the atrial rate is so fast that the AV node becomes overwhelmed and only lets some of those signals through to the ventricles creating an irregular tachycardia but at lower rates. In atrial flutter, the atrial rate is slower, therefore the AV node has more capability to conduct allowing for higher ventricular rates. Therefore, to achieve rate control one will need a higher dose of AV blocking medications. Atrial tachycardia may require even higher doses due to the increased ability of the AV node to conduct, as the atrial rates are slower than in atrial flutter. Sodium channel blockers (Class I) such as flecainide and propafenone slow wavefront propagation, making it easier for the AV node to handle the atrial rates. This will end up leading to increased ventricular rates which can be dangerously fast. That is why AV nodal blockers should be used in conjunction with flecainide and propafenone. What is the role of cardioversion in atrial flutter management? Due to high success rate with atrial flutter ablation, ablation is the first line treatment. However, sometimes cardioversion may be utilized in patients depending on how symptomatic they are and how long it will take to get an ablation. Cardioversion may also be utilized preferentially when the atrial flutter was triggered by infection or cardiac surgery to see if it will come back. If cardioversion is pursued, the patient will need to be anticoagulated due to the stroke risk after the procedure due to post-conversion stunning. How effective is atrial flutter ablation? The landmark Natale et al study in 2000 demonstrated 80% success rate after radiofrequency ablation as compared to 36% in patients on anti-arrhythmic therapy. The LADIP study in 2006 further corroborated these findings. Contemporary data shows above 90% success rate of atrial flutter ablation. In patients who have had both atrial fibrillation and atrial flutter, most electrophysiologists would ablate both. However, in patients with atrial fibrillation, the atrial flutter usually is initiated by trigger spots firing in the left atrium. Once the atrial fibrillation is ablated, the flutter will become less likely. Therefore, there are those who say there's no need to ablate the flutter circuit as well. Alternatively, if a patient has severe comorbidities and/or is high risk for ablation, one may consider performing the atrial flutter ablation only since atrial flutter is harder to manage medically compared with atrial fibrillation. How do you manage atrial flutter in the acute inpatient setting? In the inpatient setting, electrical cardioversion is often limited by blood pressure and the hypotensive effects of the sedatives required. If one is awake and too hypotensive, chemical cardioversion can be pursued. The most effective anti-arrhythmic for this is ibutilide. Amiodarone is not effective for acute cardioversion. Since ibutilide prolongs refractoriness in atrial and ventricular tissue, there's a risk of long QT induced torsades de pointes. Pretreating with magneisum reduces the risk to 1-2%. References Jolly WA, Ritchie WT. Auricular flutter and fibrillation. 1911. Ann Noninvasive Electrocardiol. 2003;8(1):92-96. doi:10.1046/j.1542-474x.2003.08114.x McMichael J. History of atrial fibrillation 1628-1819 Harvey - de Senac - Laënnec. Br Heart J. 1982;48(3):193-197. doi:10.1136/hrt.48.3.193 Lee KW, Yang Y, Scheinman MM; University of Califoirnia-San Francisco, San Francisco, CA, USA. Atrial flutter: a review of its history, mechanisms, clinical features, and current therapy. Curr Probl Cardiol. 2005;30(3):121-167. doi:10.1016/j.cpcardiol.200 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e167. doi:10.1161/ Cosío F. G. (2017). Atrial Flutter, Typical and Atypical: A Review. Arrhythmia & electrophysiology review, 6(2), 55–62. https://doi.org/10.15420/aer.2017.5.2 https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-11/Atrial-flutter-common-and-main-atypical-forms Natale A, Newby KH, Pisanó E, et al. Prospective randomized comparison of antiarrhythmic therapy versus first-line radiofrequency ablation in patients with atrial flutter. J Am Coll Cardiol. 2000;35(7):1898-1904. doi:10.1016/s0735-1097(00)00635-5 Da Costa A, Thévenin J, Roche F, et al. Results from the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) trial on atrial flutter, a multicentric prospective randomized study comparing amiodarone and radiofrequency ablation after the first episode of symptomatic atrial flutter. Circulation. 2006;114(16):1676-1681. doi:10.1161/CIRCULATIONAHA.106.638395 https://www.acc.org/Membership/Sections-and-Councils/Fellows-in-Training-Section/Section-Updates/2015/12/15/16/58/Atrial-Fibrillation#:~:text=The%20first%20'modern%20day'%20account,in%20open%20chest%20animal%20models.&text=In%201775%2C%20William%20Withering%20first,(purple%20foxglove)%20in%20AFib.
Clonal mast cell disease is often missed because symptoms vary from person to person, tryptase levels can be normal, and bone marrow biopsies are hard to get. For some people, unexplained or very severe anaphylaxis may be an early sign of a clonal mast cell disease. In this episode, we review “Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation,” published in October 2025 in the Journal of Allergy and Clinical Immunology. This paper, known as the PROSPECTOR trial, is looking at how often the KIT D816V mutation can be found using a blood test in adults who have had anaphylaxis or systemic mast cell activation symptoms. We break down why KIT D816V matters, how it connects to systemic mastocytosis, why HaT needs to be considered, and how newer blood tests may help doctors catch clonal mast cell disease earlier. What we cover in our episode about KIT D816V and anaphylaxis: Setting the stage: Understanding mast cell activation and anaphylaxis. Why KIT D816V matters: How this mutation fits into clonal mast cell disease, what blood testing can reveal, and when doctors still turn to a bone marrow biopsy. Making sense of tryptase and hereditary alpha-tryptasemia (HaT): Why baseline tryptase, the “20% + 2” rule, and HaT can make screening more complicated than it seems. What the PROSPECTOR trial uncovered: How often KIT D816V appeared in people with anaphylaxis, and other results on tryptase and HaT. How this helps patients: What these findings mean for anyone with unexplained or severe anaphylaxis, and how doctors combine KIT testing, tryptase, HaT, and symptoms to decide on next steps. Other podcast episodes about mast cell disease: Ep. 127: Management of indolent mastocytosis - A clinical yardstick Ep. 126: Management of mast cell activation syndrome - A clinical yardstick Ep. 121: Avapritinib vs Placebo in Indolent Systemic Mastocytosis - PIONEER Trial Ep. 118: The ISM Disconnect - Do Patients and Providers Agree on Symptom Control? Ep. 70 How do stress and low histamine diets impact mast cell disease? Ep. 63: Mast Cell Diseases & Systemic Mastocytosis: The Basic Science Ep. 65: The Symptoms and Triggers of Mast Cell Disease *********** The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. *********** Made in partnership with The Allergy & Asthma Network. Thanks to Blueprint Medicines for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.
Why is it so expensive to build a house in America? That's a question economists, politicians and pundits have argued at length about, but can't agree on. In today's episode of Second Request, executive editor Teddy Downey sits down with Steven Xiao, Associate Professor of Finance at the University of Texas at Dallas Naveen Jindal School of Management and Ph.D candidate Zheng Liu for a robust discussion about how concentration in the homebuilding sector has led to increased costs and prices. To learn more about The Capitol Forum click here.
Interview with Chief Executive Officer, Keith BoyleOur previous interview: https://www.cruxinvestor.com/posts/new-found-gold-tsxvnfg-explorer-to-producer-8484Recording date: 3rd December 2025New Found Gold Corporation is executing a capital-efficient development strategy that combines near-term cash flow from the recently acquired Hammerdown mine with advancement of the flagship Queensway Gold Project in Newfoundland, Canada. The November 2025 Maritime Resources acquisition delivered two critical assets: a producing underground mine that poured first gold one day before closing, and the fully permitted Pine Cove mill that eliminates major infrastructure requirements for Queensway's planned 700-ton-per-day operation. Management's appointment of Cutfield Freeman to structure project financing for Queensway's $155 million initial capital requirement signals progress toward a debt-heavy capital structure, with Hammerdown cash flow serving as the equity portion to minimize shareholder dilution. Recent grade control drilling at five-meter spacing confirms exceptional grades at the Keats zone, with only 20% of results released from the 70,000-meter 2025 program. These dense drill patterns reduce estimation uncertainty in nuggety gold deposits and support anticipated resource upgrades in the 2026 technical report. Discovery of high-grade mineralization at Dropkick, located 11 kilometers from existing resources, demonstrates district-scale exploration potential beyond current mine plans. The company targets Q1 2026 permit submission for Queensway with approval expected in H2 2026, enabling development commencement toward late 2027 commercial production. Hammerdown is ramping to steady-state operations during H1 2026, providing cash generation that de-risks Queensway financing while maintaining exploration programs across both properties that could extend mine life and improve project economics.—Learn more: https://cruxinvestor.com/companies/new-found-goldSign up for Crux Investor: https://cruxinvestor.com
Interview with Jon Deluce, Founder & CEO of Abitibi Metals Corp.Our previous interview: https://www.cruxinvestor.com/posts/abitibi-metals-cseamq-high-grade-copper-expansion-project-in-canada-7823Recording date: 4th December 2025Abitibi Metals Corp. (CSE:AMQ) is rapidly emerging as a compelling copper-gold story in Quebec's prolific mining belt, with CEO Jon Deluce outlining a disciplined growth strategy centered on the company's flagship B26 deposit. After drilling over 25,000 meters in 2025, the company is targeting a substantial resource update to 25-30 million tons in 2026, up from the current 2+ million ounce gold equivalent resource.The drilling program has delivered exceptional results, including intercepts of 18% copper equivalent over 6.3 meters with 6 grams per ton gold, and 4.5% copper equivalent over 21 meters. These world-class grades demonstrate the deposit's polymetallic nature and draw comparisons to the historic Selbaie mine located just 7 kilometers away, which produced 53 million tons over two decades.Strategic capital management has been central to Abitibi's approach. The company recently completed a bought deal financing through BMO at 35 cents per share—a 65% premium to the September market price—with no warrants attached. This structure attracted institutional investors and built the treasury to $23-24 million, funding 45,000 meters of drilling through 2027 while maintaining a clean capital structure.With a market capitalization of $65 million and an enterprise value of just $40 million, Deluce believes the company remains undervalued relative to its resource potential. The 2026 exploration strategy balances systematic resource expansion through 150-meter infill drilling with aggressive 600-meter step-outs designed to test whether B26 could reach tier-one scale comparable to Selbaie's 60-million-ton endowment.Management has assembled an experienced advisory board including Victor Cantore, Craig Parry, and Shane Williams, positioning the company for Quebec's active M&A environment. Rather than accepting dilutive 20% strategic investments, Abitibi is selectively pursuing a 5% partnership with a Quebec producer that would provide validation without eliminating competitive tension or capping shareholder upside as the copper market potentially enters a sustained bull phase.View Abitibi Metals' company profile: https://www.cruxinvestor.com/companies/abitibi-metalsSign up for Crux Investor: https://cruxinvestor.com
Interview with Pascal Hamelin, President & CEO of Abcourt Mines Inc.Our previous interview: https://www.cruxinvestor.com/posts/abcourt-mines-tsxvabi-new-quebec-producer-positioned-for-growth-cash-flow-buybacks-8051Recording date: 3rd December 2025Abcourt Mines (TSXV:ABI) has successfully transitioned from exploration to production at its Sleeping Giant mine in Quebec, representing an increasingly rare case study in debt-financed mine development that avoids the severe shareholder dilution typical of traditional equity-financed builds. The company secured $12 million in financing from Nebari—including C$8 million initial tranche, $2 million follow-on, and $2 million used to buy down the Triple Flag NSR royalty from 2% to 1.5%—and commenced gold production.October 2025 production reached 475 ounces whilst operating at conservative staffing levels and building mill circuit inventory. Management projects cash flow positivity by Q2 2026 at approximately 700 ounces monthly production, with current monthly burn rate below $1 million. The Nebari credit facility includes a two-year interest-only period until July 2027, providing critical runway to demonstrate operational consistency and build cash reserves before principal repayments commence.The operational leverage inherent in Abcourt's asset base is substantial. The company operates an 800-tonne-per-day mill (permitted for 950 tonnes per day) currently running at less than 45% capacity. Management targets 350 tonnes per day by autumn 2025, with the mill processing all current mine production in approximately eight hours on day shift only. Plans include expanding to two shifts in early 2026 and eventually four shifts as production scales, providing a clear pathway to meaningful production growth without major capital investment.The constraint on production growth is labour availability rather than geological or metallurgical factors. CEO Pascal Hamelin explicitly stated: "It's not the feed, it's the people, that's the problem you're trying to solve for." The company has invested in infrastructure to address recruitment challenges, including a sleep camp commissioned in September 2024 with Phase Two expansion pending permit approval.The current mine plan supports seven years producing 25,000–33,000 ounces annually, with variation driven by grade. Management's strategic priority centres on extending mine life to 10+ years through three underground drill rigs at Sleeping Giant, then increasing mining fronts to utilise full mill capacity. This narrow-vein, high-grade mining approach—room-and-pillar methods targeting veins 30 centimetres to one metre wide—inherently limits tonnes but maximises grade, with underground samples showing visible gold exceeding 300 g/t.The Flordin discovery adds significant exploration upside. Systematic work exposed 300 metres of strike length grading 5 g/t gold over 15–20 metres width at surface, located 138 kilometres from existing mill infrastructure within a potential two-kilometre mineralised corridor. Abcourt has planned 20,000 metres of drilling for 2026—winter programmes targeting the eastern extension towards Agnico Eagle's adjacent property boundary, spring/summer/autumn programmes targeting northwestern extensions—entirely funded from operating cash flow.Management and directors hold approximately 30% ownership, having consistently supported development through equity investments. Shareholders have expressed preference for share buybacks over dividends once balance sheet permits, with capital allocation decisions driven by financial strength rather than arbitrary timelines.Sustained gold prices above US$4,000 per ounce have fundamentally improved narrow-vein deposit economics. Every US$100 increase translates to approximately US$2.5–3.3 million in additional annual revenue at current production guidance. The investment case depends on execution during the 18-month ramp-up period, successful miner recruitment, and drilling success at both assets to extend mine life and confirm district-scale potential at Flordin.View Abcourt Mines' company profile: https://www.cruxinvestor.com/companies/abcourt-mines-incSign up for Crux Investor: https://cruxinvestor.com
Private funders are increasingly shifting from funding short-term service delivery to long-term systems change, pushing nonprofits to rethink their role in their community. Many are now asking, how do we stay mission-focused while building the relationships needed to attract funders who want deeper change? In today's episode, we explore the idea of power ecosystems — what they are, how they work, and why they're reshaping the nonprofit-funder relationship. Tune in to learn how to identify your power ecosystem, build collective power, and engage private funders more effectively. Want to suggest a topic, guest, or nonprofit organization for an upcoming episode? Send an email with the subject "NPFX suggestion" to contact@ipmadvancement.com. Additional Resources Public Health and Racial Equity (PHaRE) Model for Systems Change https://gingerleeglobal.com/public-health-and-racial-equity-phare-model-for-systems-change/ [NPFX] Rethinking How We Do Good: What We Can Learn from This Funding Crisis https://www.ipmadvancement.com/npfx/rethinking-how-we-do-good-what-we-can-learn-from-this-funding-crisis [NPFX] Federal Funding Uncertainty: How to Assess the Risks and Respond Strategically https://www.ipmadvancement.com/npfx/federal-funding-uncertainty-how-to-assess-the-risks-and-respond-strategically [NPFX] Building Resilience in the Face of Funding Cuts https://www.ipmadvancement.com/npfx/building-resilience-in-the-face-of-funding-cuts [NPFX] Advocacy Matters: Defending Federal Funding for Nonprofits https://www.ipmadvancement.com/npfx/advocacy-matters-defending-federal-funding-for-nonprofits Guests Ginger Lee, DrPH, is the founder of the Ginger Lee Global Health Consulting Group, supporting communities and organizations committed to social justice and equitable systems change. Raised in low-resourced neighborhoods, she brings a deep commitment to community power building and transformational change. Dr. Lee has served as CEO of two nonprofits, a highly successful development director, a government policy maker, and president of a globally focused foundation. Her expertise centers on systems and organizational change, non-profit leadership, and on shifting traditional philanthropy to invest in systems-level solutions alongside direct service. She is the author of the research-based Public Health and Racial Equity (PHaRE) Model for Systems Change, which clarifies the mechanisms for systems transformation led by communities most impacted by inequities. https://www.linkedin.com/in/weavingchange/ https://gingerleeglobal.com/ Dr. Anthony "Tony" Iton, CEO of The Health Trust, is a physician, attorney, public health leader, and nationally recognized advocate for health equity. Over a career spanning more than 30 years, Dr. Iton has tackled systemic barriers to health and championed community-led solutions to address inequities. At The California Endowment, he served as Senior Vice President for Healthy Communities, leading the landmark $1 billion, 10-year Building Healthy Communities initiative—one of the largest philanthropic efforts of its kind in the nation. His visionary leadership focused on empowering marginalized communities, shifting policy systems, and reimagining public health practices. Dr. Iton holds an MD from Johns Hopkins University, a JD and MPH from UC Berkeley, and a BS in Neurophysiology from McGill University. He is a Lecturer of Health Policy and Management at UC Berkeley's School of Public Health and serves on the boards of national organizations focused on health equity, including the Public Health Institute and Prevention Institute. https://www.linkedin.com/in/drtonyiton/ https://healthtrust.org/ Elizabeth Silverstein has served the not-for-profit sector for more than 40 years, specializing in transformational giving, vision casting, inspiring boards, and building passionate, effective teams. Beth has been instrumental in cultivating major gifts for capital campaigns in healthcare, two presidential libraries, higher education, K-12 independent schools, and social service organizations. With an ardent passion for protecting and propelling the nonprofit sector, Beth has joined the team at VisionConnect, a consultancy specializing in strategic planning, coalition building, governance excellence, and nonprofit capacity building. A BoardSource-certified Governance Consultant, she is passionate about coaching boards toward purpose-driven leadership and crafting bold strategic plans that drive maximum mission impact. https://www.linkedin.com/in/elizabeth-reynolds-silverstein-b211b7a/ https://www.visionconnectllc.com/ Hosts Russ Phaneuf, a co-founder of IPM Advancement, has a background in higher education development, with positions at the University of Hartford, Northern Arizona University, and Thunderbird School of Global Management. As IPM's managing director & chief strategist, Russ serves as lead fundraising strategist, award-winning content creator, and program analyst specializing in applied system dynamics. https://www.linkedin.com/in/russphaneuf/ https://www.ipmadvancement.com/ Rich Frazier has worked in the nonprofit sector for over 35 years. In his roles as senior consultant with IPM Advancement and founder of VisionConnect LLC, Rich offers extensive understanding and knowledge in capital campaigns, fund development, strategic planning, and board of directors development. https://www.linkedin.com/in/richfrazier/ https://www.visionconnectllc.com/
Over 99% of homes contain at least one allergen, with 75% harboring three to six, yet winter allergies often masquerade as stubborn “colds” or recurrent respiratory infections. This episode confronts the core diagnostic challenge of differentiating allergy-driven symptoms from viral, bacterial, or non-allergic triggers in colder months. We delve into indoor allergen epidemiology, risk stratification for polysensitized patients, syndrome overlap in differential diagnosis, and utility of location-specific respiratory allergen profiles for diagnostic testing and interpretation. Additional topics include guideline-informed approaches to environmental exposure reduction, patient-centered therapeutic strategies, monitoring of symptom thresholds, actionable counseling for managing dust mites, pet dander, molds, mouse and cockroach allergens, and streamlining through tailored lab ordering guides and reflex pet component testing. Clinicians will gain practical insight into identifying sensitizations, guiding targeted exposure minimization, and elevating respiratory care quality for patients with persistent winter symptoms.
Bienvenue sur Sensées, le format audio de ma newsletter hebdomadaire. Chaque semaine, je vous partage avec authenticité des conseils de leadership féminin, des expériences vécues et toute l'énergie dont vous avez besoin pour réussir avec confiance et sérénité.Cette semaine : Pourquoi la vie personnelle et professionnelle s'influencent : 7 situations où les femmes leaders ne peuvent pas cloisonner.Dans cet épisode de Sensées, Jenny Chammas, mastercoach certifiée et fondatrice de Coachappy, explore un sujet auquel toutes les femmes leaders sont confrontées : la manière dont la vie personnelle et professionnelle s'entremêlent, parfois malgré nous. Car au-delà des injonctions à cloisonner, la réalité est simple : nous sommes un seul et même être, et ce que nous vivons dans notre intimité impacte notre façon de travailler. Apprendre à accueillir cette porosité plutôt qu'à la combattre est une étape cruciale pour préserver son énergie, son équilibre et son leadership.À travers sept situations réelles tirées de son expérience de coach, Jenny met en lumière comment la vie personnelle et professionnelle s'influencent profondément : la parentalité, la charge domestique, le couple, la santé, les transitions familiales, l'expatriation, la maladie, mais aussi les moments heureux comme un début de relation amoureuse. Ces exemples illustrent que vouloir cloisonner coûte bien plus d'énergie que d'accepter ce qui est. Car ce qui épuise les femmes leaders n'est pas seulement ce qu'elles vivent dans leur vie privée : c'est aussi la pression ajoutée de devoir “faire comme si de rien n'était” au travail.Ce que vous saurez faire après écoute :– Comprendre pourquoi il est illusoire de séparer strictement vie personnelle et professionnelle.– Identifier les zones de tension émotionnelle qui influencent votre performance au travail.– Reconnaître la surcharge mentale liée à la résistance, au contrôle et à la culpabilité.– Trouver une posture plus douce et plus durable pour avancer même en période de turbulence.– Apprendre à traverser les tempêtes sans perdre totalement votre énergie professionnelle.Cet épisode est une invitation à regarder avec honnêteté comment votre réalité intérieure influence vos journées et vos décisions. Plutôt que de chercher à cloisonner coûte que coûte, Jenny vous propose de développer une approche plus humaine, plus lucide et plus résiliente : accueillir ce qui se passe, ajuster votre niveau d'exigence, exprimer vos besoins lorsque c'est possible et accepter que l'équilibre n'est jamais figé.Après vingt ans de carrière en entreprise, d'expatriation, de direction, de reconversion et de parentalité, et après avoir accompagné des centaines de femmes, Jenny partage des clefs pragmatiques et profondes pour avancer avec clarté, sans s'effondrer ni se juger. Car la véritable question n'est pas “Comment cloisonner ?” mais : “Comment traverser la vie personnelle et professionnelle lorsque tout bouge en même temps ?”.Pour aller plus loin, découvrez le programme Sensées, conçu pour aider les femmes leaders à sortir du surmenage et à construire un leadership durable. Cliquez ici pour en savoir plus.****Rejoignez la newsletter Sensées : elle vous donne accès à un concentré de coaching, d'inspiration et à un workshop offert chaque mois. Inscrivez-vous gratuitement en cliquant ici. Tout comme sur le podcast Sensées, on y parle de leadership, d'ambition, de confiance en soi, de motivation, de carrière, d'outils de développement personnel, de management, de prise de poste, de prise de parole, et. : bref, de tout ce qui concerne le quotidien des femmes ambitieuses.***Sensées, c'est aussi un programme de coaching pour les femmes dirigeantes, top managers et entrepreneures. Au sein du programme Sensées, vous êtes accompagnée en petit groupe ET en individuel dans votre croissance professionnelle. Vous êtes aussi formée et mentorée pour incarner pleinement votre leadership, avec les maîtres mots sérénité, plaisir, hauteur et impact. Intéressée ? Cliquez ici pour en savoir plus.**Notre guide "10 leviers essentiels pour les décideuses" est un véritable concentré d'outils de coaching et de mentoring, les mêmes que nous utilisons dans le programme Sensées. Il est conçu pour toutes les directrices, dirigeantes et entrepreneures qui sont fatiguées de porter seules les responsabilités. Si vous avez l'impression que votre quotidien vous échappe petit à petit, ce guide est fait pour vous. Cliquez ici pour obtenir votre exemplaire offert !*Vous représentez une entreprise et souhaitez développer le leadership de vos talents féminins ? : cliquez ici.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Where IT's At! No.12 by The Management
This podcast was created using NotebookLM. This podcast provides a clinical overview of the profound and bidirectional relationship between diabetes and oral health, explaining that poor blood sugar regulation exacerbates the risk of severe oral diseases, while inflammation from oral infections negatively affects systemic glucose levels.
In less than a decade, OnlyFans says it has grown into a business earning $7 billion a year. The digital platform is known for letting its 4 million creators share exclusive – often NSFW – content with more than 400 million paying users. So far, creators have earned $25 billion using OnlyFans. CEO Keily Blair revealed what's next for the brand with host Jeff Berman live on stage at Web Summit in Lisbon. Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribe See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Happy Thursday, Besties!! Our Morgie girl is sick today, so after a good long post-holiday catch up (with a side crime account that happened to Tay this morning) Taylar get's into the case of Patrice Endres. Patrice was 38 years old when she disappeared from her hair salon in Cumming, GA (Forsyth County) on April 15, 2004 without a trace. Over the years, several developments and discoveries would come to light, but what happened to Patrice that day remains a mystery. Thanks so much for spending your Thursdays with us, besties! We love you so much and will talk to you on Tuesday in the TBB for Taylar's spiral that we have hinted at for 4 weeks now!! TTYL Need to Call Susan (Angel Wings and Healing Things)? Text Ellen at 704-562-3476 to book!! Make sure to tell her we sent you for a Besties only Special discount!! If you have a Creepy Account of your own you would like to submit, you can go to our Reddit (CreepsandCrimes) or email it to us at CREEPSANDCRIMES.CA@GMAIL.COM Creeps and Crimes Merch: https://creepsandcrimesmerch.com/ Join our OG Pick Me Cult (Patreon): https://patreon.com/creepsandcrimes SUBSCRIBE AND SUPPORT WHEREVER YOU GET YOUR PODCASTS: - Apple Podcast: https://podcasts.apple.com/us/podcast/creeps-and-crimes/id1533194848 - Spotify: https://open.spotify.com/show/0v2kntCCfdQOSeMNnGM2b6?si=bf5c137913dd4af7 - Youtube: https://youtube.com/@creepsandcrimespodcast?si=e6Lwuw6qvsEPBHzG Business Inquiries please contact Management: maggie@MRHentertainment.com FOLLOW US ON SOCIALS: Creeps and Crimes Podcast - Insta: https://www.instagram.com/creepsandcrimespodcast/?hl=en - Facebook: https://www.facebook.com/creepsandcrimespodcast/ - TikTok: https://www.tiktok.com/@creepsandcrimes Taylar Jane (True Crime Host) - Insta: @Taylarj - TikTok (True Crime Channel): @TaylarJane98 - TikTok (Personal): @TaylarJane1 Morgan Harris (Paranormal & Conspiracy Host) - Insta: @morgg.m - Tiktok: @morgg.m Want More Info? Check out our Website: www.creepsandcrimespodcast.com Send Us Mail & Fan Art to our PO Box!!! CREEPS AND CRIMES PODCAST PO BOX 11523 KNOXVILLE, TENNESSEE 37939 Have a Creepy Account You'd like to share and be featured on the Podcast? Email it to: CreepsAndCrimes.CA@gmail.com Submit it through the Portal on our Website (Listed above) or Post in on our Reddit Thread with the tag "creepy account" Love our TBB episodes and want to get in on the Action or submit an AIMS? Head over to our Reddit Community: @creepsandcrimes Need to contact us or request sources? Email us at creepsandcrimespodcast@gmail.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
The Tropical MBA Podcast - Entrepreneurship, Travel, and Lifestyle
Sticking rigidly to your sales scripts, hiring and firing sales reps, and positioning yourself as a freelancer instead of the expert: these mistakes will cost you in 2026 if you don't address them now. 6-figure fractional sales manager, Jeff Pecaro, joins us once again to reveal his best sales insights and call us out on the mistakes we need to leave behind in 2025. Plus, we get into how he and other 6-7 figure businesses inside Dynamite Circle are scaling with just one human and multiple bots. LINKS How to work with Jeff (https://meetwingman.com/) Jeff's favorite microphone for sales calls (https://www.amazon.com/Shure-MV7X-Podcast-Microphone-Voice-Isolating/dp/B09BZZCGC8/) Get 2 months of Perspective AI FREE with promo code TMBA (https://getperspective.ai/tmba) Share your thoughts about the podcast (https://getperspective.ai/interview/tmba-feedback) [takes 2 minutes] Connect with 6-, 7- & 8-figure founders in Dynamite Circle (https://dynamitecircle.com/dcbkk) Hang out exclusively with 7+ figure founders (https://dynamitecircle.com/dc-black) 22 FREE business resources for location-independent entrepreneurs (https://tropicalmba.com/resources) CHAPTERS (00:00:13) Today's Guest: Jeff Pecaro (00:01:44) The Biggest Challenge Holding Back Your Sales (00:05:00) Start Positioning Yourself as the Expert (00:14:31) Conversion Rate Benchmarks to Aim For (00:18:59) How to Go From “Good Call” to $ in the Bank (00:26:33) Sales Best Practices in 2026 (00:32:24) 2026 Bootstrapper Trends and Predictions CONNECT: Dan@tropicalmba.com Ian@tropicalmba.com Past guests on TMBA include Cal Newport, David Heinemeier Hannson, Seth Godin, Ricardo Semler, Noah Kagan, Rob Walling, Jay Clouse, Einar Vollset, Sam Dogan, Gino Wickam, James Clear, Jodie Cook, Mark Webster, Steph Smith, Taylor Pearson, Justin Tan, Matt Gartland, Ayman Al-Abdullah, Lucy Bella. PLAYLIST: Your 2026 Business Plan in 36 Minutes (https://tropicalmba.com/episodes/2026-business-plan) [FREE Resource] $400K in Points & 100% Vibe Coded Shopify Forecasting App with “SpyGuy” Allen Walton (https://tropicalmba.com/episodes/400k-in-points-vibe-coded-app) The Lifestyle Business Playbook (2025 Edition) (https://tropicalmba.com/episodes/lifestyle-business-playbook-2025)
I was out drinking martinis with Cora Opsahl, director of 32BJ Health Fund, and Cora said, "Look, most plan sponsors' biggest expense is health system spend, hospital spend." I know this is an unexpected start to an episode about pharmaceutical pricing and value featuring Sarah Emond, CEO of ICER (Institute for Clinical and Economic Review). But yeah, 50% of most plan sponsors' spend these days goes to health systems. Fifty percent! One half! For a full transcript of this episode, click here. If you enjoy this podcast, be sure to subscribe to the free weekly newsletter to be a member of the Relentless Tribe. So, if a patient who is adherent to a drug and that drug keeps that patient out of the hospital, why do I want to make a patient have excessive skin in the game to get that drug, which everybody knows at this point this "skin in the game" can cause said patient to not be adherent in many cases, cost being a very big reason patients give for not taking medications as prescribed. So then we have this not adherent patient who winds up in the hospital, via the ER often enough. The core issue here that surfaced, bottom line—and I'm not sure if this was in spite of the martinis or as a result of them—but while hospital spend is the largest health expense, high-value drugs that prevent hospitalization often face patient cost sharing and access restrictions, which leads to poor patient adherence and ultimately higher system cost potentially. So then Cora and I spent the next half hour debating when the statement is empirically true and when it's not. And you know what it all boils down to? What's the value of the drug? Do we even know what that means to start? But if it's determined that the drug is relatively high value, then the plan desperately should want to do everything possible to keep that patient on that medication, and cost sharing is a huge barrier to adherence. Today, as I said, I'm speaking with Sarah Emond, CEO over at ICER, and we get into all of this in the conversation that follows. In fact, most of the conversation that follows explores the tensions that exist in the current way that we sell and buy pharmaceutical products. I'm just gonna sum up these tensions in a list here at the top of this show. There's six of them that Sarah Emond and I discussed today by my counting, and each of these we explore in some depth. So, here's the list. Tension 1: The value of any given drug (in other words, what is the fair price for that drug considering the health gains that it delivers) versus the total cost to the plan for the total population taking that drug. GLP-1s have entered the chat. GLP-1s (by ICER's analysis, at least) are super high-value drugs that also can bankrupt plans due to the number of folks who may benefit from taking the drug. Definitely a tense tension to kick off our list here. Tension 2: The list or net price of a drug versus patient access and affordability. Again, this can be tense in an area of much misalignment. You can have a great well-priced drug with huge patient affordability and access challenges because drug net price and coinsurance amounts often have nothing to do with each other. Tension 3: Lifetime value of a drug versus a 3-, 2.5-year, whatever time horizon that many plan sponsor actuaries use in their value assessment. We discussed this today, but there's a Summer Short (SUMS7) on actuarial value horizons with Keith Passwater and JR Clark if you wanna dig in on this further. Tension 4: The tension between the societal value of a drug or even the patient's perceived value of a drug versus what an employer plan sponsor might perceive as the value. What is the formula used to determine value? What's in and what's out? So, that's a bigger conversation just beyond the time horizon for what's included in this calculation. Tension 5: Exacerbating the what's included in the value contemplation beyond just what you include in there is the tension between what is hypothetically of value and what is possible to measure. If you have pharma datasets and medical datasets separate in silos, who knows how many hospital readmissions were prevented by whatever drug? And how much presenteeism or absenteeism exists. I mean, it is an outlier, again, if anyone even knows the net price they paid for a drug, just to level set context here. Tension 6: Lowering financial barriers for patients to take drugs that are of value versus status quo goals and incentives. Like, for example, PBMs (pharmacy benefit managers) are often told that their goal is to reduce drug spend. Okay … so, how do I do that? Oh, reduce access either by prior auths or delay tactics or really high coinsurance, which is gonna reduce adherence by design. And it's someone else's problem—if I'm just thinking like a status quo PBM—if medical spend goes up, right? So, that's our last and not insignificant tension. And look, who comes out the loser in all of these tensions when they get tense? Patients. Not pricing based on value and not buying and setting up cost sharing based on value punishes patients and also plan sponsors or any other ultimate purchaser in the long term, given that the plan is but a population of patients if you start thinking about it in that context. Here is Sarah's advice in a nutshell: Pharma, sell. Pick your price based on something other than market power. And some pharma companies are actually dipping their toe into these waters and doing it. But then PBMs and plan sponsors have to hold up their end of the bargain here and buy drugs based on their value, not just the size of their rebates or some other discounting promise. And then we gotta continue the through line through to member affordability and access. High-value drugs should get preferred. So, right, do a high-value formulary. Listen to the show with Nina Lathia, RPh, MSc, PhD (EP426) on high-value formularies and then listen (after you're done with that one) to episode 435 with Dan Mendelson entitled "Optimized Pharmacy Benefits Are Required if You Want to Do or Buy Value-Based Care." Also, as I said, GLP-1s come up in this conversation, so … yeah, buckle up. One last thing, besides my normal thank you to Aventria Health Group for sponsoring this episode, I am so pleased to thank Payerset for donating to help Relentless Health Value stay on the air. Payerset is a price transparency company with a mission to create fair and equitable healthcare for everyone. Love that. Payerset empowers healthcare organizations, employers, and patients with the most complete set of healthcare price transparency data. They benchmark every negotiated rate and claim and delivering the actionable insights needed for smarter contract negotiations and a more transparent healthcare system. As I have said several times today, my conversation is with Sarah Emond, CEO of ICER. Also mentioned in this episode are Institute for Clinical and Economic Review (ICER); Cora Opsahl; 32 BJ Health Fund; Keith Passwater; JR Clark; Nina Lathia, RPh, MSc, PhD; Dan Mendelson; Aventria Health Group; Payerset; Antonio Ciaccia; Elizabeth Mitchell; Purchaser Business Group on Health (PBGH); Shane Cerone; Sam Flanders, MD; Mark Cuban; Morgan Health; and Tom Nash. For a list of healthcare industry acronyms and terms that may be unfamiliar to you, click here. You can learn more at ICER.org and follow Sarah on LinkedIn. Sarah K. Emond, MPP, is president and chief executive officer of the Institute for Clinical and Economic Review (ICER), a leading nonprofit health policy research organization, with 25 years of experience in the business and policy of healthcare. She joined ICER in 2009 as its first chief operating officer and third employee and has worked to grow the organization's approach, scope, and impact over the years. Prior to joining ICER, Sarah spent time as a communications consultant, with six years in the corporate communications and investor relations department at a commercial-stage biopharmaceutical company and several years with a healthcare communications firm. Sarah began her healthcare career in clinical research at Beth Israel Deaconess Medical Center in Boston. A graduate of the Heller School for Social Policy and Management at Brandeis University, Sarah holds a Master of Public Policy degree with a concentration in health policy. Sarah also received a bachelor's degree in biological sciences from Smith College. Sarah speaks frequently at national conferences on the topics of prescription drug pricing policy, comparative effectiveness research, and value-based healthcare. 08:18 Why list prices are a lie. 10:59 How does the rebate model sometimes get in the way of paying for value? 12:50 Bonus clip with Sarah Emond. 13:14 EP491 with Elizabeth Mitchell. 13:20 EP490 and EP492 with Shane Cerone and Sam Flanders, MD. 14:37 The tension that is created between affordability and adherence. 15:03 When cost sharing makes sense in pharmaceutical drug pricing. 17:26 INBW42 with Stacey on moral hazard. 18:53 How GLP-1s are "wildly cost effective." 21:32 Why the sticker shock on cost-effective drugs is a failure in the system for paying for value. 22:38 ICER's report on GLP-1s. 26:59 EP385 with Dan Mendelson. 28:57 How employers and payers can have a value assessment approach and a health insurance system that allows access to cost-effective drugs. 29:48 How cost-effective prices are calculated. 31:55 One of the core value underpinnings for value assessment of drugs. 34:54 Why manufacturers and pharmacy benefit managers should work together more by referencing something like an ICER report. 36:55 EP426 with Nina Lathia, RPh, MSc, PhD. 38:21 "We can make different choices." You can learn more at ICER.org and follow Sarah on LinkedIn. @sarahkemond discusses #pharmaceutical #drugpricing on our #healthcarepodcast. #healthcare #podcast #financialhealth #patientoutcomes #primarycare #digitalhealth #healthcareleadership #healthcaretransformation #healthcareinnovation Recent past interviews: Click a guest's name for their latest RHV episode! Stacey Richter (INBW43), Olivia Ross (Take Two: EP240), John Quinn, Dr Sam Flanders and Shane Cerone (EP492), Elizabeth Mitchell (EP491), Shane Cerone and Dr Sam Flanders (Part 1), Dan Greenleaf (Part 2), Dan Greenleaf (Part 1), Mark Cuban and Cora Opsahl
Not gonna give much of an introduction here because this is a short bonus level set, but I did just wanna call everyone's attention to the "arms race" created by our status quo purchasing and selling of many things, pharmaceuticals included. For a full transcript of this episode, click here. If you enjoy this podcast, be sure to subscribe to the free weekly newsletter to be a member of the Relentless Tribe. For example, raise the list price of a drug to maximize rebates, because the higher the list, the bigger the discount you can give, which then exacerbates patient affordability because coinsurance is often based on list price. But then Pharma starts offering co-pay cards, which messes up the whole PBM (pharmacy benefit manager) plan to drive patients to their highest-rebate products (ie, the most profitable products). So then maximizers and accumulators enter the chat, and prior auths ramp up because plans start having to raise premiums after enough 340B drugs with high lists and no rebates, and then there's no cost containment and raise deductibles and around and around we go. Meanwhile, is this drug fundamentally worth the list price or even the net price? Is it an effective drug? What's the right price to be paying for this drug? Should be the operative question, right? Just like what's the quality and appropriateness of any medical service? Maybe we should just quit it and just pay for value. And with that, let me introduce Sarah Emond, CEO of ICER (Institute for Clinical and Economic Review), and I will let Sarah tell the rest of the story. Also mentioned in this episode are Institute for Clinical and Economic Review (ICER); Cora Opsahl; 32 BJ Health Fund; Payerset; Aventria Health Group; Dea Belazi, PharmD, MPH; and Tom Nash. For a list of healthcare industry acronyms and terms that may be unfamiliar to you, click here. You can learn more at ICER.org and follow Sarah on LinkedIn. Sarah K. Emond, MPP, is president and chief executive officer of the Institute for Clinical and Economic Review (ICER), a leading nonprofit health policy research organization, with 25 years of experience in the business and policy of healthcare. She joined ICER in 2009 as its first chief operating officer and third employee and has worked to grow the organization's approach, scope, and impact over the years. Prior to joining ICER, Sarah spent time as a communications consultant, with six years in the corporate communications and investor relations department at a commercial-stage biopharmaceutical company and several years with a healthcare communications firm. Sarah began her healthcare career in clinical research at Beth Israel Deaconess Medical Center in Boston. A graduate of the Heller School for Social Policy and Management at Brandeis University, Sarah holds a Master of Public Policy degree with a concentration in health policy. Sarah also received a bachelor's degree in biological sciences from Smith College. Sarah speaks frequently at national conferences on the topics of prescription drug pricing policy, comparative effectiveness research, and value-based healthcare. 02:28 What is ICER? 02:47 What does the Institute for Clinical and Economic Review do? 05:09 The importance of still showing up, even when others don't understand or disagree. 06:51 EP293 ("Game Theory Gone Wild") with Dea Belazi, PharmD, MPH. 09:04 Why it's important to think about population health and how our choices impact affordability for everyone. You can learn more at ICER.org and follow Sarah on LinkedIn. @sarahkemond discusses #ICER and the status quo of #pharmaceuticaldrug #pricing on our #healthcarepodcast. #healthcare #podcast #financialhealth #patientoutcomes #primarycare #digitalhealth #healthcareleadership #healthcaretransformation #healthcareinnovation Recent past interviews: Click a guest's name for their latest RHV episode! Stacey Richter (INBW43), Olivia Ross (Take Two: EP240), John Quinn, Dr Sam Flanders and Shane Cerone (EP492), Elizabeth Mitchell (EP491), Shane Cerone and Dr Sam Flanders (Part 1), Dan Greenleaf (Part 2), Dan Greenleaf (Part 1), Mark Cuban and Cora Opsahl
WELCOME TO THE VIBE! This week, Kelly Cardenas sits down with the visionary Founder & CEO of Lovesac, Shawn D. Nelson! (Nasdaq: LOVE).We're diving into the mindset of the man who started his journey by making Sacs by hand in college in 1998 and scaled it into the fastest-growing furniture brand in the US, now projected to exceed $1 Billion in annual sales. Get ready for a masterclass in entrepreneurship, sustainable design, and disruptive innovation!In this game-changing conversation, you'll learn about:The Branson Blueprint: The legendary story of how Shawn won a million-dollar investment from Sir Richard Branson on The Rebel Billionaire and served as acting President of Virgin Worldwide.Design Meets Strategy: How his Master's degree in Strategic Design and Management from the world-famous Parsons, The New School for Design shaped Lovesac's strategy.The Sactionals Secret: The innovation behind the Sactionals platform—the world's most versatile couch—and how Shawn holds over 50 issued patents.True Sustainability: An in-depth look at his unique "Designed For Life" philosophy, which demands products are built to last a lifetime and evolve, promoting genuine sustainability.Lessons for Leaders: Insights from his book, Let Me Save You 25 Years, detailing the colorful history, "mistakes, miracles, and lessons" learned while building a vibrant culture.Connect with Kelly Cardenas & The Vibe:Connect with Shawn D. Nelson:Visit or listen to his Let Me Save You 25 Years podcast to learn more.
Jerry Schill is the founder and CEO of Schill Grounds Management — a company he launched in 1993 with his brother after a chance summer job revealed a passion for landscaping. What began as a two-person side hustle has grown into a large-scale commercial grounds management company, now one of the fastest-growing platforms in the industry.In 2020, Jerry began a bold new chapter—scaling Schill Grounds Management through strategic acquisitions alongside organic growth. Under his leadership, the company has completed more than 16 acquisitions and now operates across six states and Ontario, Canada. With a growing family of nine brands and more than 1,400 team members, Schill Grounds Management is recognized as a national leader built on consistency, performance, and a people-first culture — and Jerry is still very much in building mode.Beyond the business, Jerry is an active contributor to several industry associations, including the National Association of Landscape Professionals, the Accredited Snow Contractors Association, and the Ohio Landscape Association. He also founded Holiday Feast — an annual charitable tradition that has served thousands of free meals to families in need throughout the Cleveland community.Throughout our awesome conversation, Jerry reflects on entrepreneurship, drive, discipline, humility, ambition, what it means to build something that lasts, and lots more.00:00 Introduction to Jerry Schill and His Journey00:59 The Impact of Family and Early Influences01:49 The Leap into Entrepreneurship03:54 The Evolution of Show Landscape07:21 Understanding the Landscaping Industry13:08 Leadership Evolution and Personal Growth19:04 The Importance of Peer Networks20:58 Scaling the Business and Maintaining Culture24:32 The Shift to Acquisitions for Growth27:47 Integrating Acquired Companies Successfully31:38 The Role of Technology in Landscaping34:47 Motivation and Future Vision for SGM38:09 Lessons Learned from the Journey39:55 Curiosity and Lifelong Learning41:13 The Holiday Feast Initiative44:08 Aiming for a Billion-Dollar Company45:46 Advice to Younger Self46:56 Hidden Gems in Cleveland-----LINKS:https://schilllandscaping.com/abouthttps://www.linkedin.com/in/jerry-schill-2b010b1a/Referenced Episode — Sanjay Singh: https://www.layoftheland.fm/218-sanjay-singh-macer-get-good-at-hard-things/-----SPONSOR:Roundstone InsuranceRoundstone Insurance is proud to sponsor Lay of The Land. Founder and CEO, Michael Schroeder, has committed full-year support for the podcast, recognizing its alignment with the company's passion for entrepreneurship, innovation, and community leadership.Headquartered in Rocky River, Ohio, Roundstone was founded in 2005 with a vision to deliver better healthcare outcomes at a more affordable cost. To bring that vision to life, the company pioneered the group medical captive model — a self-funded health insurance solution that provides small and mid-sized businesses with greater control and significant savings.Over the past two decades, Roundstone has grown rapidly, creating nearly 200 jobs in Northeast Ohio. The company works closely with employers and benefits advisors to navigate the complexities of commercial health insurance and build custom plans that prioritize employee well-being over shareholder returns. By focusing on aligned incentives and better health outcomes, Roundstone is helping businesses save thousands in Per Employee Per Year healthcare costs.Roundstone Insurance — Built for entrepreneurs. Backed by innovation. Committed to Cleveland.-----Stay up to date by signing up for Lay of The Land's weekly newsletter — sign up here.Connect with Jeffrey Stern on LinkedIn — https://www.linkedin.com/in/jeffreypstern/Follow Lay of The Land on X @podlayofthelandhttps://www.jeffreys.page/
Send us a textAYOOOO! Welcome back to Luck Management. We have got a solo episode after still riding the high of having on my incredible sister Julia Dillon. So many incredible people shared, listened, and watched the podcast. Thank you and welcome to the "Luckies" family! This week, you get me SOLO... but don't worry this is an awesome episode filled with some new segments and some great discussion around the Famous "Grateful 4", My 29th Birthday, New Segment: Luck Pending (Challenge you to grow!), and of course..... Notre Dame football. Really enjoyed making this episode for you all and hope you can enjoy the ride of the topics. Hopefully you pick something up and always know I am grateful for you luckies. As always, keep living the Luck Management Lifestyle! Support the showInstagram: @luck_managementApple Podcasts: https://podcasts.apple.com/podcast/id1637190216Spotify: https://open.spotify.com/show/4JsxM55BY6tRlGzJCiUnvzBrought to you by CharmND. Check us out on Instagram @charm_ND & @CharmNDShop on EtsyKeep living The Luck Management Lifestyle!
In this episode of Wisdom's Table, I dive into the often overwhelming experience of December, a month that can feel both beautiful and brutal. As a mom of four, I share my personal struggles with the mental load that comes with juggling family commitments, holiday expectations, and the demands of running a business. I discuss the concept of mental load—an invisible weight that encompasses the decisions, reminders, and emotional energy required to manage our lives and the people we care about. Throughout the episode, I emphasize the importance of recognizing our current capacity and honoring the season we are in. I encourage listeners to slow down and let go of the pressure to be superhuman, reminding them that if God has called us to something, we have the capacity for it, even if we can't do it all at once. I outline three key strategies to help manage the mental load and maintain peace during this busy time. Let's connect! Get my weekly emails in your inbox and let's grow together HERE TIMESTAMPS 00:00:01 - Welcome to Wisdom's Table Introduction to the podcast and the theme of December's challenges. 00:01:28 - Understanding Mental Load Explaining the concept of mental load and its impact on daily life. 00:04:36 - Honoring Your Season The importance of recognizing and respecting your current capacity. 00:09:00 - Aligning Priorities The significance of alignment in managing tasks and responsibilities. 00:12:39 - Mindfulness of Overflow vs. Overload Living from a place of overflow rather than being overwhelmed. 00:18:04 - Conclusion and Reflection Final thoughts on peace, capacity, and the presence of God in our lives.
Something New! For HR teams who discuss this podcast in their team meetings, we've created a discussion starter PDF to help guide your conversation. Download it here https://goodmorninghr.com/EP229 In episode 229, Coffey talks with Frank Davis and John Surma about navigating OSHA inspections and preventing costly workplace safety violations. They discuss how employers misunderstand OSHA obligations; when OSHA reporting and injury-logging rules apply; the most-cited OSHA violations; triggers that prompt an OSHA inspection; why it is illegal to for OSHA to schedule an inspection with an employer; the importance of carefully limiting the scope of the inspection; OSHA's interviews managers and employees—and the impact of each on the inspection's outcome; documentation requests and timelines; citation outcomes and settlement options; and proactive strategies to prepare for inspections and avoid penalties. Good Morning, HR is brought to you by Imperative—Bulletproof Background Checks. For more information about our commitment to quality and excellent customer service, visit us at https://imperativeinfo.com. If you are an HRCI or SHRM-certified professional, this episode of Good Morning, HR has been pre-approved for one hour of recertification credit. To obtain the recertification information for this episode, visit https://goodmorninghr.com. About our Guest: Frank Davis is Board Certified in labor and employment law by the Texas Board of Legal Specialization. His clients know he is ready to use his knowledge to manage a crisis on a moment's notice. In fact, in the last year, he managed labor relations matters and workplace safety inspections and fatalities in over 35 different states. Frank's experience managing crisis events makes him especially suited to counsel clients on strategies to avoid catastrophic litigation and other cost-savings efforts: - Evaluation of exposure to workplace health and safety hazards. - Preparation of workplace safety compliance strategies and policies. - Managing employee relations to avoid litigation and resist organizing drives by unions; and - Management of relations with unions to avoid frivolous grievances and exposure to contract liability. Because of Frank's specialized skillset, his clients frequently retain him to handle a variety of sensitive matters: - Fatalities and other reportable injuries in the workplace; - Collective bargaining of labor contracts; - Labor arbitrations; - Union campaigns; - Contract litigation; and - Litigation before the National Labor Relations Board (NLRB) and the Occupational Safety and Health (OSHA) Review Commission. He also represents clients in whistleblower matters under a broad range of statutes, including the OSH Act, the Surface Transportation Assistance Act, and the Clean Air Act. Frank handles all phases of these complaints, from initial investigation to final litigation before administrative law judges and appeals to federal court. John Surma is a lawyer with 30 plus years of experience dealing with OSHA, workplace health and safety issues, and counseling employers on those issues. He deals with a variety of state and federal agencies, has responded to over 400 fatalities and 2,000 OSHA inspections. Frank Davis and John Surma can be reached at https://ogletree.com/people/frank-d-davis/ https://www.linkedin.com/in/john-surma-75980214 About Mike Coffey: Mike Coffey is an entrepreneur, licensed private investigator, business strategist, HR consultant, and registered yoga teacher. In 1999, he founded Imperative, a background investigations and due diligence firm helping risk-averse clients make well-informed decisions about the people they involve in their business. Imperative delivers in-depth employment background investigations, know-your-customer and anti-money laundering compliance, and due diligence investigations to more than 300 risk-averse corporate clients across the US, and, through its PFC Caregiver & Household Screening brand, many more private estates, family offices, and personal service agencies. Imperative's Top Ten Red Flag Candidates, November 2025 Every month, Imperative reports hundreds of records to our clients. While Imperative always encourages clients to review candidates' criminal history as but one factor in evaluating their fit for a role, these candidates' histories caught our attention this month. 1. Household Staff/Nanny Client Candidate: Prostitution Petit larceny 2. Nonprofit Client Candidate: Misuse of client funds by a lawyer (four counts) 3. Hospitality Client Candidate: Willful child cruelty (causing great bodily injury under the age of five years, victim was particularly vulnerable, or taking advantage of a position of trust to commit offense) Driving under the influence, 2 cases Reckless driving on a highway See the rest of the list here: https://www.imperativeinfo.com/blog/2025/12/03/top-ten-red-flag-candidates-november-2025/ Learning Objectives: Identify when OSHA reporting and recording rules apply and what events trigger each requirement. Evaluate common OSHA violations to prioritize hazard prevention strategies. Prepare supervisors and frontline employees for OSHA interviews and onsite inspection protocols. Navigate the inspection, citation, and settlement processes to reduce organizational risk.
Howie and Harlan are joined by Sudhakar Nuti to discuss his work improving healthcare for homeless New Yorkers, as a street-medicine doctor and a population-health leader at NYC Health + Hospitals. Harlan reports on a proposed law that would cut off funding for U.S. scientists who collaborate with colleagues in China; Howie provides updates on the measles outbreak and a leaked FDA memo claiming that COVID-19 vaccines have killed 10 children. Show notes: Science Across Borders Subtitle C—SAFE Research Act "U.S. Congress considers sweeping ban on Chinese collaborations" Sudhakar Nuti NYC Health + Hospitals Street Medicine Institute "Health Care beyond Clinic Walls—Sustaining and Scaling Up Street Medicine" NYC Health + Hospitals: Street Health Outreach & Wellness Mobile Units "Graduate and professional students tackle food insecurity" California Depart of Public Health: Xylazine Measles CDC: Measles Cases and Outbreaks "Tracking U.S. Measles Outbreaks" World Health Organization: Weekly Epidemiological Record, 2025, vol. 100, no. 48 "Winning against measles: five charts that tell a remarkable 24-year story" "Measles deaths down 88% since 2000, but cases surge" FDA Leak "Experts say top FDA official's claim that Covid vaccines caused kids' deaths requires more evidence" "FDA's Prasad tells staffers agency plans to get tougher on vaccine regulation, blames child deaths on COVID shots" "Thoughts on Vinay Prasad's Leaked Email" "Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021" "Fulminant Myocarditis and Cardiogenic Shock Following COVID-19 Infection Versus COVID-19 Vaccination: A Systematic Literature Review" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.
Interview with Segun Lawson, CEO of Thor Exploration Ltd.Our previous interview: https://www.cruxinvestor.com/posts/thor-exploration-lsethx-nigerian-pioneer-preps-18m-oz-senegal-gold-project-for-q4-pfs-7891Recording date: 3rd December 2025Thor Explorations presents a compelling investment opportunity combining immediate cash generation from low-cost, high-grade gold production with a self-funded development pipeline spanning near-term mine life extension, advanced-stage project construction, and genuine exploration discoveries across three West African jurisdictions.The company operates the 100%-owned Segilola gold mine in Nigeria, producing 90,000–95,000 ounces annually at all-in sustaining costs below $1,000 per ounce. At current gold prices above $4,000 per ounce, Thor captures operating margins exceeding $3,000 per ounce, creating substantial free cash flow that funds quarterly dividends whilst simultaneously financing aggressive exploration and development programmes without equity dilution. Q3 2025 operational results demonstrated this financial strength, with production of 22,600 ounces generating approximately $70 million in revenue. Management's strategic decision to withhold 3,000 ounces for Q4 sale above $4,000 per ounce positions the company for potentially record quarterly financial performance. Thor has completely repaid its project debt, achieving a debt-free balance sheet that provides exceptional strategic flexibility for capital allocation decisions. This financial position distinguishes Thor from capital-constrained peers and enables the company to advance multiple projects simultaneously across different development stages.The Segilola operation represents Thor's immediate value creation opportunity through mine life extension. The company has deployed five drilling rigs exploring beneath the existing pit, systematically intersecting high-grade underground mineralisation averaging 5.5 grams per tonne (g/t) compared to open pit grades of just over 4 g/t. With all infrastructure capital expenditure already sunk and operational expertise established, every additional ounce discovered creates what management characterizes as "super ounces" requiring minimal incremental capital to extract. Thor targets an updated resource estimate in Q1 2026 whilst also pursuing satellite deposits within a 50-kilometre radius of the processing plant. The company plans a pilot mining operation in 2026 at one southern target, supplementing an existing stockpile containing over 44,000 ounces representing more than $175 million in contained gold value.Thor's Douta project in Senegal represents material near-term production growth, with a preliminary feasibility study weeks from completion. The project carries estimated capital costs of $250–$300 million, of which Thor will self-fund $150 million from operational cash flows. The remaining $100 million will be sourced through debt financing with Africa Finance Corporation, which financed Segilola and maintains an equity stake. Management targets first gold production in Q1 2028 following an investment decision expected in H1 2026, with the project featuring a larger resource base than Segilola and approximately 10 years of mine life that would materially increase Thor's consolidated production profile.Early-stage exploration success in Côte d'Ivoire provides genuine blue-sky discovery potential. At Guitry, 4,600 metres of drilling has delineated six mineralised lenses with high-grade intersections including 10 metres at 10 g/t across just 15% of an 8-kilometre by 5-kilometre geochemical footprint. The Marahui project has identified 8 kilometres of drill targets with surface rock chips returning 10–17 g/t. Both projects advance toward maiden resource estimates in H1 2026 through continuous drilling programmes funded entirely from internal cash generation.Thor's investment proposition centres on operational execution, financial strength, and portfolio diversification. The company's ability to generate substantial cash flows whilst advancing multiple growth opportunities without external capital requirements creates a differentiated risk-reward profile. Multiple near-term catalysts through 2026 include the Douta feasibility study release, Segilola resource update, Côte d'Ivoire maiden resources, construction decision-making, and continued operational cash generation supported by elevated gold prices and proven low-cost production capabilities.View Thor Exploration's company profile: https://www.cruxinvestor.com/companies/thor-explorations-ltdSign up for Crux Investor: https://cruxinvestor.com
In this episode we talk with John Guaspari about the common pitfalls leaders and organizations make when it comes to driving employee engagement. During our time together we discuss:Why employee engagement has been such a challenge historically (and currently) for leaders and organizations.The four intangibles leaders need to leverage the full potential of their workforce.How to tell if you are a really good leader.What "empowerment" really looks like.The importance link between customer focus and employee engagement.How leaders who want people to come to the office everyday can navigate this challenge without disengaging their workforce.If you are interested in more from John, pick up a copy of his book, If Engagement is the What, then Respect is the How.In addition, take a look at these two articles John wrote about stories he referenced in this episode: We Make People Happy john-guaspari-ced4ca.webflow.io - this is an article about the work John did at National Grange Mutual (NGM) A Shining Example john-guaspari-ced4ca.webflow.io - this article tells what happened after their national claims center burned down—how everyone recognized how critical this was and joined forces to get the claims function back up and running with very little down time.
Je suis très heureuse de vous proposer cet épisode hors-série sur ls angles morts RH, né d'une conversation que j'ai eue en juin dernier avec plusieurs DRH pour préparer la nouvelle saison du podcast.Comme toujours, mon objectif est d'aller chercher des sujets que l'on n'aborde pas ailleurs et d'éviter de répéter ce qui existe déjà.J'ai donc voulu comprendre avec eux quels étaient les angles morts RH, ces points qui traversent les organisations sans être véritablement nommés.J'ai souhaité partager plus largement ces échanges, les prolonger et en faire un débat ouvert.Dans cet épisode, nous mettons en lumière ces angles morts RH, non pas pour en dresser la liste, mais pour comprendre ce qu'ils disent des organisations aujourd'hui.Nous avons été accueillis chez Chateauform, dans la maison des Jardins de Saint-Dominique, avec toute la chaleur qui fait partie de leur culture.Ce cadre a permis d'installer un climat propice à un échange simple et direct. Ce choix n'était pas anodin : j'ai un lien particulier avec Chateauform, depuis mes débuts professionnels. Ce sont des lieux propices aux conversations qui comptent, des conversations sincères et profondes, exactement ce que je voulais installer ce jour-là.J'ai eu la joie et l'honneur de recevoir pour cet épisode inédit :• Magali Charlin Gaudin, responsable des richesses humaines, talents et cultures – Chateauform• Claire Gathier-Caillaud, DRH – Safran Electronics & Defense• Jean-Yves Chameyrat, DRH – STEFEnsemble, ils mettent en mots ce qui circule réellement dans les équipes : des sujets du quotidien, parfois isolés, qui dessinent pourtant des lignes de fond dans le travail des collaborateurs, des managers et des RH.Ils évoquent notamment :• des signaux faibles liés à la santé au travail, difficiles à catégoriser ;• la charge portée par les managers face à des situations nouvelles ;• la contrainte du temps, entre rythme opérationnel et disponibilité ;• la circulation des responsabilités et la question de “qui fait quoi” ;• le rôle du collectif et des relais internes ;• des décisions qui engagent plusieurs prismes (talent, entreprise, planète).Ces angles morts révèlent aussi une dynamique plus large :un cadre de fonctionnement sous tension, des responsabilités qui se déplacent, des situations qui débordent les repères habituels, et un manque de temps qui fragilise la capacité à réguler.Cet échange apporte un éclairage différent sur la transformation du management, les dynamiques de confiance et le défi RH dans l'accompagnement des équipes.Un épisode utile pour comprendre ce qui se joue réellement dans les organisations.Bonne écoute!
Philippians 2:12 KJVWherefore, my beloved, as ye have always obeyed, not as in my presence only, but now much more in my absence, work out your own salvation with fear and trembling.
Why do leaders jump so quickly to giving advice? And why does it so often backfire? In this episode, Michael Bungay Stanier explains why the “advice monster” is one of our biggest leadership liabilities—and how seven simple questions can help you listen better, coach smarter, and build stronger connections. Filled with humor, story, empathy, and practical scripts, this episode is a masterclass in everyday leadership.Memorable Quotes“When you ask a question and they actually have to think about it, you're literally creating new neural pathways in their brain—or at least they're creating their own neural pathways—so they're literally becoming smarter right in front of you.”“More deeply than an ‘answer,' much of the time people want to feel deeply heard, deeply seen, and deeply encouraged. And your ‘answer' often means they feel less seen, less heard, and less encouraged.”“One of the great moments of claiming adulthood is being clear on what you want to say ‘yes' to—and knowing that inevitably you have to say ‘no' to things to get that.”“Every time you jump in with your ideas and your opinions and your advice—particularly if it's your default reaction—you're basically reinforcing, ‘I'm better than you are. I'm smarter and wiser and older and faster and just generally better than you. You are not as good as I am.' There's a degree to which you're diminishing that other person rather than helping them.”“There's a time and a place where [giving advice] is the right thing to be doing. The way I define coaching is: Can you stay curious a little bit longer? Can you rush to action and advice-giving a little bit more slowly?”“One of the phrases I've started saying to people who are going through a tough time is simply, ‘I'm Team Michael. I'm Team Megan.…I'm Team whoever that person might be.' It's my way of saying, ‘I love you and I want the best for you, and I don't even know what to do—or I can't think of anything to do—so I'm just trying to be with you in this moment.'”“One of the questions that I've found most helpful—particularly if I'm the more senior person in the relationship—is: ‘What needs to be said that hasn't yet been said?'”Key TakeawaysThe “Advice Monster” Is Real. Our instinct to help by offering answers often diminishes others. Curiosity, not certainty, is what truly empowers people.Questions Create Ownership. When people generate their own ideas, they're more confident, more committed, and more capable.Seven Questions Change Everything. Michael's practical framework gives you a simple playbook for better conversations. His personal favorite? “And what else?”Curiosity Deepens Every Relationship. Parents, partners, bosses—everyone benefits when you resist the urge to fix and choose to listen instead.Better Conversations Start With Permission. Rather than assume what someone needs, lead with humility and ask: How can I be most useful here?Coaching Is for Everyday Life. You don't have to be a professional coach for this to matter. These tools transform team meetings, parenting moments, and even difficult conversations at home.ResourcesThe Coaching Habit by Michael Bungay StanierThe Advice Trap by Michael Bungay StanierHow to Work With (Almost) Anyone by Michael Bungay StanierBox of Crayons (Curiosity-driven leadership program)Watch on YouTube at: https://youtu.be/WOjq8aMbr5kThis episode was produced by Sarah Vorhees Wendel of VW Sound
The State Of The Union of churches in 2025, bad Jesus interactions, Pastor load management, Going to online church, and pastors using AI… On the net, it's a positive. ----- JOKES FOR HUMANS TOUR: https://johncristcomedy.com/tour/ 12/5 - Phoenix, AZ 12/6 - Santa Rosa, CA 12/7 - Redding, CA 12/11 - South Bend, IN 12/12 - Munhall, PA 12/14 - Buffalo, NY 1/23 - Joliet, IL 1/24 - Effingham, IL 1/25 - Nashville, TN 2/20 - Springfield, MO 2/22 - Louisville, KY 2/26 - Ithaca, NY 2/27 - Reading, PA 2/28 - Glenside, PA 3/1 - New York, NY 3/20 - Jackson, MI 3/21 - Rockford, IL 3/22 - Cedar Rapids, IA 3/27 - Columbia, MO 3/28 - Fayetteville, AR 3/29 - Little Rock, AR 4/10 - Stockton, CA 4/11 - Anaheim, CA 4/12 - Thousand Oaks, CA 4/17 - Tucson, AZ 4/18 - Houston, TX 5/2 - Fort Worth, TX 5/3 - Amarillo, TX 5/14 - Wilmington, NC 5/15 - Evans, GA 5/16 - Durham, NC 5/29 - Jacksonville, FL 5/30 - Asheville, NC 5/31 - Columbia, SC 6/4 - Mobile, AL 6/5 - Florence, AL 6/6 - Duluth, GA ----- Catch the full video podcast on YouTube, and follow us on social media (@netpositivepodcast) for clips, bonus content, and updates throughout the week. ----- Email us at netpositive@johncristcomedy.com ----- FOLLOW JOHN ON: Instagram Twitter TikTok Facebook YouTube ----- SUPPORT OUR SPONSORS AG1: Get a FREE gift with your first order at https://DrinkAG1.com/netpositive to get started with AG1's Next Gen and and notice the benefits for yourself. BLUELAND: Get 30% off your order by going to https://blueland.com/netpositive MIRACLE MADE: Save OVER 40% + 3 free towels with promo code NETPOSITIVE at https://trymiracle.com/NETPOSITIVE ----- PRODUCED BY: Alex Lagos / Easton Smith / Lagos Creative Learn more about your ad choices. Visit megaphone.fm/adchoices
Ann Wolbert Burgess is no ordinary nurse or researcher—she helped shape the FBI's profiling program and redefined forensic nursing. In this episode of Remarkable People, she shares gripping insights from the Menendez brothers trial, the Duke lacrosse case, and decades of work with victims of trauma. We also discuss her new book Expert Witness, which shines light on what really happens inside courtrooms and why hearing the “other side” of a story is crucial for justice.---Guy Kawasaki is on a mission to make you remarkable. His Remarkable People podcast features interviews with remarkable people such as Jane Goodall, Marc Benioff, Woz, Kristi Yamaguchi, and Bob Cialdini. Every episode will make you more remarkable.With his decades of experience in Silicon Valley as a Venture Capitalist and advisor to the top entrepreneurs in the world, Guy's questions come from a place of curiosity and passion for technology, start-ups, entrepreneurship, and marketing. If you love society and culture, documentaries, and business podcasts, take a second to follow Remarkable People.Listeners of the Remarkable People podcast will learn from some of the most successful people in the world with practical tips and inspiring stories that will help you be more remarkable.Episodes of Remarkable People organized by topic: https://bit.ly/rptopologyListen to Remarkable People here: **https://podcasts.apple.com/us/podcast/guy-kawasakis-remarkable-people/id1483081827**Like this show? Please leave us a review -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!Thank you for your support; it helps the show!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, we explore how pediatricians can create safe, inclusive spaces for discussing sexual health. Our hosts review evidence-based recommendations for STI screening and treatment, emphasizing how to tailor care to the diverse needs of young patients. We also discuss practical approaches to communicating results, preserving confidentiality, and empowering youth with tools for STI prevention.
We all know by now that plants grown in living, thriving, life-filled soil, give us living, thriving, life-filled food... but the steps to getting there in the face of a multinational industry devoted to toxic, nutritionally empty, addictive - and highly profitable - ultra-processed 'food-like substances' are harder to see. This week's guest, Daphne du Cros, spends her life deep in the mycelial networks of food and farming systems, bringing both into genuinely regenerative balance. Daphne is a food policy researcher, educator, and farmer. She holds a PhD in Food Policy at the Centre for Food Policy at City St. George's University of London, and a Master's in Environmental Science and Management from Toronto Metropolitan University in Canada. She is Director and Coordinator at Shropshire Good Food Partnership; Director at Light Foot Enterprises; Project Lead at Food Forward BC (where BC stands for Bishop's Castle, not British Columbia or any of the other potential options) - and she's co-owner of Little Woodbatch CIC, a farm just outside BC that hosts the Bishop's Castle Community Seed Bank. She is the author of the town's Community Food Resilience Strategy - the only such policy in Shropshire.Daphne and I are relatively near neighbours, we have swapped seeds - her more than me - and share ideas about systems thinking and how we might evolve our world. She's deeply involved at every level from actual growing up to governmental meetings trying to get those in power to find some wisdom when it comes to food resilience, food security and all the other things we say as we try to get them to move away from the corruption innate in our system towards something that actually works in service to life. Daphne on LinkedIn https://uk.linkedin.com/in/daphne-du-cros-743128332Instagram: https://www.instagram.com/littlewoodbatch/ Shropshire Good Food Partnership: https://www.shropshiregoodfood.org/Instagram: https://www.instagram.com/shropshiregoodfood/ Soil Ed UK: https://www.instagram.com/soil_ed_uk/ Gaia Foundation Seed Sovereignty Network: https://www.seedsovereignty.info/Serving the Public https://uk.bookshop.org/p/books/serving-the-public-the-good-food-revolution-in-schools-hospitals-and-prisons-kevin-morgan/7657661?ean=9781526180469&next=tCivil Food Resilience Report: https://nationalpreparednesscommission.uk/publications/just-in-case-7-steps-to-narrow-the-uk-civil-food-resilience-gap/ Little Woodbatch Farm https://www.littlewoodbatch.co.uk/What we offer: Accidental Gods, Dreaming Awake and the Thrutopia Writing Masterclass If you'd like to join our next Open Gathering offered by our Accidental Gods Programme it's 'Dreaming Your Year Awake' (you don't have to be a member) on Sunday 4th January 2026 from 16:00 - 20:00 GMT - details are hereIf you'd like to join us at Accidental Gods, this is the membership where we endeavour to help you to connect fully with the living web of life. If you'd like to train more deeply in the contemporary shamanic work at Dreaming Awake, you'll find us here. If you'd like to explore the recordings from our last Thrutopia Writing Masterclass, the details are here
It's Ticked Off Tuesday, and Jared is hearing 4 new complaints! First, we hear about his condo management miscommunications. Then we go into listener emails. A listener sold an air purifier to a friend's mom and now is somehow stuck mailing a random remote to a stranger? Then, someone is frustrated with UberEats tipping because it keeps messing up their orders. Next, a cat owner is annoyed that friends keep giving cheap toys that break and leave glitter everywhere. And finally, a listener who loves hosting is tired of Thanksgiving food being boring and wants it to taste better.Eat smart @ http://factormeals.com/jtrain50off & use code jtrain50off to get 50% off your first box, plus Free Breakfast for 1 year.
A recent New York Times headline — “Did Women Ruin the Workplace?” sparked a firestorm across social media. Bob Safian welcomes a leader pushing back on this notion with data and nuance: Alison Moore, CEO of Chief, the prestigious network for senior women executives. Drawing from an exclusive nationwide survey of women leaders, Moore unpacks how evolving career paths are being misread, why women-centered spaces remain vital, and the rise of the multihyphenate leader. As a former HBO executive, Moore also reveals how she's applying lessons from Game of Thrones to Chief, and how she stays attuned to the cultural pulse, from AI to shifting leadership expectations.Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Hello Besties and Happy Tuesday!! Hope your Thanksgivings went well! Today, we have a crappy co-workers themed Bestie Bonus for you! Starting off with the Question of the Week: "What's the craziest thing a coworker or employee has ever done to you?" before getting into our AIMS or Am I Missing Something Submission from Reddit: Previous Employee is Harassing Me, AIMS? Thanks so much for joining us! Can't wait to catch up with you on Thursday! Talk to ya then, love ya!! Thank you to everyone who has submitted an AIMS for TBB, if you would like to submit one you can do so through our Reddit @CreepsandCrimes or our email creepsandcrimes.ca@gmail.com with the title being AIMS? ----------------------- Need to Call Susan (Angel Wings and Healing Things)? Text Ellen at 704-562-3476 to book!! Make sure to tell her we sent you for a Besties only Special discount!! If you have a Creepy Account of your own you would like to submit, you can go to our Reddit (CreepsandCrimes) or email it to us at CREEPSANDCRIMES.CA@GMAIL.COM Creeps and Crimes Merch: https://creepsandcrimesmerch.com/ Join our OG Pick Me Cult (Patreon): https://patreon.com/creepsandcrimes SUBSCRIBE AND SUPPORT WHEREVER YOU GET YOUR PODCASTS: - Apple Podcast: https://podcasts.apple.com/us/podcast/creeps-and-crimes/id1533194848 - Spotify: https://open.spotify.com/show/0v2kntCCfdQOSeMNnGM2b6?si=bf5c137913dd4af7 - Youtube: https://youtube.com/@creepsandcrimespodcast?si=e6Lwuw6qvsEPBHzG Business Inquiries please contact Management: maggie@MRHentertainment.com FOLLOW US ON SOCIALS: Creeps and Crimes Podcast - Insta: https://www.instagram.com/creepsandcrimespodcast/?hl=en - Facebook: https://www.facebook.com/creepsandcrimespodcast/ - TikTok: https://www.tiktok.com/@creepsandcrimes Taylar Jane (True Crime Host) - Insta: @Taylarj - TikTok (True Crime Channel): @TaylarJane98 - TikTok (Personal): @TaylarJane1 Morgan Harris (Paranormal & Conspiracy Host) - Insta: @morgg.m - Tiktok: @morgg.m Want More Info? Check out our Website: www.creepsandcrimespodcast.com Send Us Mail & Fan Art to our PO Box!!! CREEPS AND CRIMES PODCAST PO BOX 11523 KNOXVILLE, TENNESSEE 37939 Have a Creepy Account You'd like to share and be featured on the Podcast? Email it to: CreepsAndCrimes.CA@gmail.com Submit it through the Portal on our Website (Listed above) or Post in on our Reddit Thread with the tag "creepy account" Love our TBB episodes and want to get in on the Action or submit an AIMS? Head over to our Reddit Community: @creepsandcrimes Need to contact us or request sources? Email us at creepsandcrimespodcast@gmail.com Learn more about your ad choices. Visit podcastchoices.com/adchoices